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Toxicology communications最新文献

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Improvement in delirium and visuospatial function after rivastigmine in antimuscarinic toxicity: a case report 雷瓦斯汀抗毒后谵妄和视觉空间功能的改善:1例报告
Pub Date : 2023-09-01 DOI: 10.1080/24734306.2023.2253688
M. Correia, R. G. Hendrickson
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引用次数: 0
Delayed antidotal fomepizole in massive acetaminophen overdose: a case report 大量对乙酰氨基酚过量延迟解毒剂福美唑1例报告
Pub Date : 2023-08-30 DOI: 10.1080/24734306.2023.2250968
Michael A. Chary, Caroline Vizzi, Xavier Jimenez
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引用次数: 0
Suspected snakebite in a tertiary referral centre in Western Sydney: a 10-year case series 疑似蛇咬伤在西悉尼三级转诊中心:一个10年的病例系列
Pub Date : 2023-08-28 DOI: 10.1080/24734306.2023.2249704
P. Chandru, Govind Atwal, Omar Aziz, Mark Salter
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引用次数: 0
A yew by any other name 任何其他名字的紫杉
Pub Date : 2023-08-16 DOI: 10.1080/24734306.2023.2241007
N. Vance
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引用次数: 0
Pediatric colchicine poisoning with survival after a “lethal” overdose: a case report 儿童秋水仙碱中毒与“致命”过量后的生存:一个病例报告
Pub Date : 2023-07-22 DOI: 10.1080/24734306.2023.2236916
Wiem Barbaria, Ichrak Khamassi, Mohamed Fkili
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引用次数: 0
Evaluation of commercially available methamphetamine presumptive tests for site contamination 对市售甲基苯丙胺场地污染推定试验的评价
Pub Date : 2023-07-21 DOI: 10.1080/24734306.2023.2238154
Emma J. Kuhn, G. S. Walker, Harriet Whiley, Jackie Wright, Kirstin E. Ross
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引用次数: 1
Proceedings of the Toxicology and Poisons Network Australasia (TAPNA) 2023 Annual Scientific Meeting 澳大利亚毒理学与毒物网络(TAPNA)2023 年科学年会论文集
Pub Date : 2023-07-06 DOI: 10.1080/24734306.2023.2222509
Rachelle Abouchedid, Sarah Hodgson, Anselm Wong, Ingrid Berling, Thomas Sullivan, Joshua Bloom, Gar Chan, Mark Su, Kate Cleary, Natasha Tile, Aisling Kiely, R. Syrjanen, Jennifer Schumann, Shaun Greene, A. Holford, Christopher Martin, Andrew Staib, Keith Harris, K. Isoardi, Benjamin Horan, Benjamin Learmont, Christina Needham, Lucy Shieffelbien, Brian O’Riordan, Jonathan Lee, Joseph Rotella, Rowena Penafiel, Gina Chowdhury, Darren M Roberts, Nazila Jamshidi, Stuart Duffin
Arsenicals induce their toxic effects by binding to sulfhydryl groups in multiple enzyme systems, inhibiting metabolism and disrupting oxidative phosphorylation generating reactive oxygen species. In animal studies NAC has been shown to decrease arsenic mediated oxidative damage and in in vitro studies NAC was shown to chelate arsenic. The optimal time to commence NAC therapy has not been studied, but animal studies have shown earlier treatment improved survival. Given its favourable safety profile, low cost and the findings from animal studies, NAC should be used as an adjunct to standard chelation therapy in arsenic poisoning. Further investigation is required to establish the optimal duration of treatment and dosing.
砷通过与多种酶系统中的巯基结合、抑制新陈代谢和破坏氧化磷酸化生成活性氧而产生毒性作用。在动物实验中,NAC 可减少砷介导的氧化损伤;在体外实验中,NAC 可螯合砷。目前尚未研究开始 NAC 治疗的最佳时间,但动物实验表明,早期治疗可提高存活率。鉴于其良好的安全性、低成本和动物实验结果,NAC 应被用作砷中毒标准螯合疗法的辅助疗法。要确定最佳治疗时间和剂量,还需要进一步的研究。
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引用次数: 0
Challenges in care of snake envenomation in rural Pakistan: a narrative review 巴基斯坦农村照顾蛇中毒的挑战:叙述回顾
Pub Date : 2023-06-19 DOI: 10.1080/24734306.2023.2223049
R. Memon, T. Erickson, C. Goldfine
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引用次数: 0
Repeated daily dosing of weekly methotrexate therapy causing multiorgan toxicity: a case report 每周甲氨蝶呤治疗引起多器官毒性的每日重复剂量:一个病例报告
Pub Date : 2023-06-16 DOI: 10.1080/24734306.2023.2221508
E. Davey, G. Isbister
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引用次数: 0
Fatal ingestion of Taxus brevifolia (Pacific yew): a case report 短叶红豆杉(太平洋红豆杉)误食致死1例
Pub Date : 2023-06-09 DOI: 10.1080/24734306.2023.2220532
C. Temple, A. Lopez
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引用次数: 1
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Toxicology communications
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