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Angiomyofibroblastoma: Imaging and histopathology of a rare benign mesenchymal tumor 血管肌成纤维细胞瘤:一罕见良性间充质肿瘤的影像学及病理分析
Pub Date : 2019-01-01 DOI: 10.4103/TJOG.TJOG_79_17
A. Kulkarni, M. Tinmaswala, S. Shetkar, S. Kondekar
Angiomyofibroblastomas, aggressive angiomyxomas and cellular angiofibromas are rare mesenchymal tumours with many overlapping radiological, histopathological and immunohistochemical features. Amongst these tumours angiomyofibroblastoma is relatively benign mesenchymal tumour with very low chances of recurrence. It is clinically confused with bartholin gland cyst due to its well demarcated and smooth appearance. Due to overlapping histopathological features its very difficult even for experienced pathologists to differentiate between these mesenchymal tumours. Earlier desmin reactivity was thought to be specific for angiomyofibroblastoma but recently many aggressive angiomyxomas have also been found to be positive for desmin. Ultrasound, computed tomography and magnetic resonance imaging may be useful in diagnosis and ruling out more sinister malignancies. A well demarcated lesion with characteristic histopathological appearance of alternating hypo and hypercellular edematous regions with abundant blood vessels and stromal cells with dispersed chromatin is usually seen in angiomyofibroblastoma. Immunohistochemistry may further help in diagnosis. We here report a case of vaginal angiomyofibroblastoma. The diagnosis was made on the basis of imaging and was confirmed by histopathology and immunohistochemistry.
血管肌纤维母细胞瘤、侵袭性血管粘液瘤和细胞血管纤维瘤是罕见的间质肿瘤,具有许多重叠的放射学、组织病理学和免疫组织化学特征。在这些肿瘤中,血管肌成纤维细胞瘤是相对良性的间充质肿瘤,复发率极低。由于其清晰的边界和光滑的外观,临床上常与bartholin腺囊肿混淆。由于组织病理特征重叠,即使是经验丰富的病理学家也很难区分这些间充质肿瘤。早期的促球蛋白反应性被认为是血管肌成纤维细胞瘤所特有的,但最近许多侵袭性血管粘液瘤也发现促球蛋白阳性。超声,计算机断层扫描和磁共振成像可能有助于诊断和排除更险恶的恶性肿瘤。血管肌成纤维细胞瘤通常表现为界限清晰的病变,其组织病理学特征是伴有丰富的血管和染色质分散的间质细胞的低细胞和高细胞交替的水肿区。免疫组织化学可以进一步帮助诊断。我们在此报告一例阴道血管肌成纤维细胞瘤。诊断依据影像学,经组织病理学和免疫组织化学证实。
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引用次数: 2
Lithopedion coexisting with a huge uterine fibroid: A case report 结石合并巨大子宫肌瘤1例
Pub Date : 2019-01-01 DOI: 10.4103/TJOG.TJOG_32_18
B. Sulaiman, M. Sani, A. Binji, R. Ibrahim
A lithopedion (stone baby) is a rare phenomenon seen in advanced abdominal pregnancy. There are few cases reported in Africa. This is a case report of a 50-year-old woman who presented with a complaint of an abdominal swelling for 15 years. She was suspected to have a uterine fibroid. She was subsequently prepared for myomectomy. Intraoperatively, she was found to have a calcified intact fetus with a coexisting huge uterine fibroid. She had extirpation of the calcified fetus and myomectomy. She did well postoperatively and was discharged home on the 7th day.
足结石(结石婴儿)是一种罕见的现象,见于晚期腹部妊娠。非洲报告的病例很少。这是一位50岁女性的病例报告,她主诉腹部肿胀长达15年。她被怀疑患有子宫肌瘤。随后,她准备进行子宫肌瘤切除术。在手术中,她被发现有一个钙化的完整胎儿,并伴有巨大的子宫肌瘤。她摘除了钙化的胎儿并切除了子宫肌瘤。她术后表现良好,于第7天出院回家。
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引用次数: 3
Vaginal bacteriome of Nigerian women in health and disease: A study with 16S rRNA metagenomics 尼日利亚妇女健康和疾病中的阴道细菌组:16S rRNA宏基因组学研究
Pub Date : 2019-01-01 DOI: 10.4103/TJOG.TJOG_67_18
K. Anukam, N. Agbakoba, A. Okoli, C. Oguejiofor
Introduction: The argument on what bacteria make up healthy vagina and bacterial vaginosis (BV) remain unresolved. Black women most often are placed in grade IV vaginal communities as lacking Lactobacillus-dominated microbes. We sought to determine the vaginal microbiota compositions of healthy and those with BV using 16S rRNA metagenomics methods. Materials and Methods: Twenty-eight women provided vaginal swabs for Nugent scoring. Fifteen had BV (Nugent score 7–10), whereas 13 were normal (Nugent score 0–3). DNA was extracted and 16S rRNA V4 region amplified using custom bar-coded primers prior to sequencing with MiSeq platform. Sequence reads were imported into Illumina BaseSpace Metagenomics pipeline for 16S rRNA recognition. Distribution of taxonomic categories at different levels of resolution was done using Greengenes databases. Manhattan principal component analysis was used for similarity clustering. Results: Non-BV subjects were colonized by 12 taxonomic phyla that represent 182 genera and 357 species. Overall, 23 phyla representing 388 genera and 805 species were identified in BV subjects. Firmicutes represented 95% of the sequence reads in non-BV subjects with Lactobacillus-dominated genera and Lactobacillus crispatus–dominated species, followed by Proteobacteria (3.78%), Actinobacteria (0.74%), and Bacteriodetes (0.05%). In BV subjects, Firmicutes represented 59% of the classified sequence reads, followed by Bacteroidetes (19%), Actinobacteria (15.8%), Fusobacteria (4.08%), Proteobacteria (1.48%), and Tenericutes (1.25%). Conclusion: Non-BV healthy Black African, Nigerian women had Lactobacillus genera as the predominant microbiota, contrary to published reports. The study shows that BV subjects had varying proportions of diverse bacteria similar to studies from other parts of the world.
引言:关于什么细菌构成健康阴道和细菌性阴道病(BV)的争论仍未解决。黑人女性通常被安置在四级阴道群落中,因为缺乏以乳酸杆菌为主的微生物。我们试图使用16S rRNA宏基因组学方法来确定健康人和BV患者的阴道微生物群组成。材料和方法:28名女性提供阴道拭子进行Nugent评分。15人患有BV(Nugent评分7-10),13人正常(Nugent得分0-3)。在用MiSeq平台测序之前,提取DNA并使用定制的条形码引物扩增16S rRNA V4区域。将序列读数导入Illumina BaseSpace宏基因组学管道,用于16S rRNA识别。使用Greengenes数据库对不同分辨率级别的分类类别进行了分布。相似性聚类采用Manhattan主成分分析。结果:非BV受试者被12个分类门定殖,共代表182属357种。总的来说,在BV受试者中鉴定出23个门,代表388属和805种。在非BV受试者中,厚壁菌门占序列读数的95%,属以乳酸杆菌为主,种以脆乳杆菌为主,其次是变形菌门(3.78%)、放线菌门(0.74%)和细菌门(0.05%),变形杆菌属(1.48%)和Tenericutes属(1.25%)。结论:与已发表的报告相反,非BV健康的非洲黑人尼日利亚妇女的乳酸杆菌属是主要的微生物群。这项研究表明,BV受试者有不同比例的不同细菌,类似于世界其他地区的研究。
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引用次数: 9
Fetal imaging and diagnosis services in developing countries – A call to action 发展中国家的胎儿成像和诊断服务——行动呼吁
Pub Date : 2019-01-01 DOI: 10.4103/TJOG.TJOG_59_18
J. Akinmoladun, D. Anumba
Fetal congenital anomalies are among the leading causes of perinatal death or survival with disability worldwide. Their accurate antenatal detection employing a range of fetal imaging techniques enables parental choices to be made and for postnatal care of affected babies to be planned. While such prenatal care is well developed in developed countries of the world, it remains poor in many low- and middle-income countries (LMICs). This review article examines the scope of the problem and proffers strategies for service organization and fetal imaging that will improve care in LMIC settings.
胎儿先天性异常是全世界围产期死亡或残疾生存的主要原因之一。他们采用一系列胎儿成像技术进行准确的产前检测,使父母能够做出选择,并计划受影响婴儿的产后护理。虽然这种产前护理在世界发达国家很发达,但在许多低收入和中等收入国家仍然很差。这篇综述文章检查了问题的范围,并为服务组织和胎儿成像提供了策略,这将改善低收入家庭的护理。
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引用次数: 8
The effect of hyoscine butyl bromide in shortening the duration of first stage of labor: A single-blind randomized control study 丁溴海莨菪碱缩短第一产程持续时间的效果:一项单盲随机对照研究
Pub Date : 2019-01-01 DOI: 10.4103/TJOG.TJOG_57_18
R. Ibrahim, E. Nwobodo, K. Tunau, A. Burodo, B. Sulaiman, J. Garba, A. Saidu
Background: Active management of labor reduces the number of prolonged labor and the duration of labor without having any adverse effects on the mother and the fetus. Intervention with drugs is among the options used for active management of labor. This includes use of analgesics, oxytocics, prostaglandins derivatives, and smooth muscle relaxants. The objectives of the study were to determine whether hyoscine N butyl bromide (HNBB) shortens the first stage of labor in term pregnancies, to compare the mean duration of labor between primigravidae and multigravidae in HBB group, to compare the maternal and fetal outcome between HBB and control group, and also to determine the side effects of HBB in parturients. Materials and Methods: The study was a single-blind randomized control study carried out in Usmanu Danfodiyo University Teaching Hospital (UDUTH) over 4-month period. A total of 204 pregnant women at term in spontaneous labor who presented in active phase of labor at UDUTH and have met the inclusion criteria were recruited and randomized into 102 women as case group and 102 women as control. The women in the case group received 40 mg (2 mls) of HBB, while those in the control group received 2 mls of normal saline. Data entry and analysis was done with IBM SPSS version 20. The duration and outcome was monitored. Results: The mean duration of labor in the first stage among the case group was 5:44 ± 2:11, while it was 6:52 ± 2:11 among the control group representing a decrease of 16.5%. This was statistically significant (P < 0.05). There was no difference in the duration of the second and third stages of labor among the two groups. There was no difference in the maternal and neonatal outcome among the two groups. Vomiting was the only maternal side effect that was statistically significant among the HBB group. Conclusion: HBB reduced the duration of first stage of labor in both primigravid and multigravid women without adverse maternal and neonatal complications. It is recommended that HBB to be given to women in active phase of labor to reduce the incidence of prolonged labor.
背景:积极管理产程可减少产程延长次数和产程持续时间,对母婴无不良影响。药物干预是积极管理分娩的选择之一。这包括使用镇痛药、催产素、前列腺素衍生物和平滑肌松弛剂。本研究的目的是确定海莨菪碱N丁基溴化剂(HNBB)是否缩短足月妊娠的第一产程,比较HBB组初产妇和多胎产妇的平均产程,比较HBB组与对照组的母胎结局,以及确定HBB对产妇的不良反应。材料与方法:本研究为单盲随机对照研究,在乌斯马努丹佛迪约大学教学医院(UDUTH)进行为期4个月的研究。本研究共招募了204例在UDUTH产程处于活跃期的自然分娩足月孕妇,符合纳入标准,随机分为102例作为病例组,102例作为对照组。病例组的妇女接受40毫克(2毫升)的HBB,而对照组的妇女接受2毫升生理盐水。数据输入和分析使用IBM SPSS version 20完成。监测治疗的持续时间和结果。结果:病例组第一产程平均为5:44±2:11,对照组为6:52±2:11,缩短了16.5%。差异有统计学意义(P < 0.05)。两组第二、三产程的持续时间无差异。两组的产妇和新生儿结局没有差异。呕吐是HBB组中唯一有统计学意义的产妇副作用。结论:HBB减少了原孕和多孕妇女第一产程的持续时间,没有不良的产妇和新生儿并发症。建议在产程活跃期给予HBB,以减少延长产程的发生。
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引用次数: 2
Office cystometry in a resource-constrained setting: Spectrum of diagnoses and correlation with QUID 资源受限环境下的办公室膀胱术:诊断谱及与QUID的相关性
Pub Date : 2019-01-01 DOI: 10.4103/TJOG.TJOG_4_19
S. Bola-Oyebamiji, O. Badejoko, I. Awowole, Z. Abdur-Rahim, M. Ajayi, A. Salako
Background: Office cystometry is an appropriate technology alternative to urodynamics, especially in resource-poor settings. The combination of a validated screening tool such as the Questionnaire for Urinary Incontinence Diagnosis (QUID) and office cystometry stands as the gold standard in the evaluation of urinary incontinence, where urodynamics is not available. Objectives: This study aimed to determine the spectrum of urinary incontinence diagnoses using a combination of urogynecological examination and office cystometry among women in a resource-constrained sub-Saharan African setting and to correlate this with their QUID diagnoses. Methods: Sixty consenting women who had urinary incontinence diagnosed with QUID were recruited from a related study. The cough stress test was performed to elicit stress incontinence. Standard digital and speculum examinations were performed. Postvoid residual urine volume was determined by catheterization. Simple cystometry was performed to detect detrusor overactivity. Using urogynecological examination and simple cystometry as the gold standard, sensitivity, specificity, positive, and negative predictive values were calculated for QUID. Results: The spectrum of diagnoses made using urogynecological examination and office cystometry included no incontinence 13 (21.7%), urge incontinence 23 (38.3%), stress incontinence 18 (30.0%), mixed incontinence 5 (8.3%), and overflow incontinence in 1 (1.7%) woman, respectively. Using this as the gold standard, QUID demonstrated sensitivity of 87.0%, 55.6%, and 60.0% for urge, stress, and mixed incontinence, respectively, with corresponding specificity of 73.0%, 81.0%, and 83.6%, respectively. Conclusion: Urogynecological examination and office cystometry identified stress, urge, mixed, and overflow urinary incontinence in the study population. Overall, good correlation existed between the QUID and office cystometric diagnoses.
背景:办公室膀胱测量是泌尿动力学的一种合适的替代技术,特别是在资源贫乏的环境中。结合有效的筛查工具,如尿失禁诊断问卷(QUID)和办公室膀胱测定法,在尿动力学不可用的情况下,作为尿失禁评估的金标准。目的:本研究旨在确定在资源受限的撒哈拉以南非洲地区妇女中使用泌尿妇科检查和办公室膀胱测定相结合的尿失禁诊断谱,并将其与QUID诊断相关联。方法:从一项相关研究中招募了60名同意诊断为QUID的尿失禁妇女。咳嗽压力测试诱发应激性尿失禁。进行标准指镜检查。空后残余尿量通过导尿法测定。简单膀胱术检测逼尿肌过度活动。以泌尿妇科检查和简单膀胱术为金标准,计算QUID的敏感性、特异性、阳性预测值和阴性预测值。结果:通过泌尿妇科检查和办公室膀胱检查,诊断出无尿失禁13例(21.7%),急迫性尿失禁23例(38.3%),压力性尿失禁18例(30.0%),混合性尿失禁5例(8.3%),溢流性尿失禁1例(1.7%)。以此为金标准,QUID对急尿、压力性尿失禁和混合性尿失禁的敏感性分别为87.0%、55.6%和60.0%,特异性分别为73.0%、81.0%和83.6%。结论:泌尿妇科检查和办公室膀胱检查在研究人群中发现了应激性、急迫性、混合性和溢出性尿失禁。总体而言,QUID与办公室膀胱测量诊断之间存在良好的相关性。
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引用次数: 0
Effectiveness of mobile phone text message reminder on birth preparedness in a rural community in Kenya 手机短信提醒在肯尼亚农村社区分娩准备的有效性
Pub Date : 2019-01-01 DOI: 10.4103/TJOG.TJOG_84_18
C. Joyce, Omoni Grace, M. Waithira
Background: Birth preparedness is a strategy that has been found effective in preventing obstetric delays. Use of mobile technology can enable access and efficiency of health messages delivered during antenatal care. The mobile technology can be more effective in conveying health messages owing to its accessibility and enables follow up. Materials and Methods: This was a randomized control trial carried out among pregnant women attending public health antenatal clinics in Migori County. Four health facilities were randomized. Two facilities each were randomly picked for the study and control groups respectively. A total of 379 participants were recruited into the study. The study group participants received a verbal message on birth preparedness and a mobile phone text message reminder one month to their expected date of delivery. Follow up was done to both groups through their mobile phone contacts. Data was collected using an interviewer-administered questionnaire and analyzed using Stata version 11. Proportion tests were done to compare the groups. Results: The success rate of the study was 90.5% (n = 343). Most of the participants (73%) were aged between 20 and 34 years. Majority of them were married (79.2%) and most of them had primary level of education. Protestant was the predominant religion (55.2%). Housewives and businesswomen constituted 34.2% and 27%, respectively. The respondents in the study group who were birth prepared were 74.3% (n = 136) while those in the control group were 48.1% (n = 77). Conclusion: The use of mobile phone text message reminder in addition to verbal messages is more effective.
背景:分娩准备是一项有效预防产科延误的战略。使用移动技术可以使产前保健期间提供的卫生信息更容易获得,并更有效。移动技术可以更有效地传递健康信息,因为它的可及性和后续行动。材料和方法:这是一项随机对照试验,在Migori县公共卫生产前诊所就诊的孕妇中进行。随机选取了四家卫生机构。研究组和对照组分别随机选择了两个设施。这项研究共招募了379名参与者。研究小组的参与者在预产期前一个月收到了关于分娩准备的口头信息和手机短信提醒。研究人员通过两组人的手机通讯录对他们进行了跟踪。数据收集使用访谈者管理的问卷,并使用Stata版本11进行分析。通过比例测试对两组进行比较。结果:研究成功率为90.5% (n = 343)。大多数参与者(73%)的年龄在20到34岁之间。他们中大多数已婚(79.2%),大多数受过小学教育。新教为主要宗教(55.2%)。家庭主妇和商业女性分别占34.2%和27%。研究组有分娩准备者占74.3% (n = 136),对照组为48.1% (n = 77)。结论:手机短信提醒比口头提醒更有效。
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引用次数: 2
Harm elimination project for unsafe abortion in Nigeria: An operations research 尼日利亚不安全堕胎的危害消除项目:一项操作研究
Pub Date : 2019-01-01 DOI: 10.4103/TJOG.TJOG_70_18
E. Enabudoso, G. A. Oko-oboh, A. Ehigiegba, Jedidiah D. K. Sodje, J. Erhabor, Matthew Oriakhi, J. Onakewhor
Context: The harm elimination model is designed to improve access to pre- and postabortion care including free contraception and address the challenges posed by unsafe abortion to the sexual and reproductive health of the women recruited for the study. Aims: To determine the impact of the “Harm Elimination Project For Unsafe Abortion in Nigeria” (HELPUSAN) model on the rate of decision to keep the pregnancy by women seeking termination of pregnancy and the determinants of this decision. Subjects and Methods: Over the 6-month period of this pilot survey, all women presenting for abortion were offered preabortion and postabortion counseling and services according to the study protocol. The study did not offer abortion services based on the abortion law in Nigeria. The clients were followed up for 6 weeks and assessed on decision to continue the pregnancy or not. Results: Of 105 attendees, 12.4% declined enrolment, 59.8%had induced abortion, and 45.8% had spontaneous abortion. Among those who presented for postabortion care following induced abortion, the main method used for inducing the abortion process was drugs (80.5%). A total of 90 (97.8%) of the participants were confirmed to be pregnant of which 52 (57.8%) were viable. Also, of the 52 participants with viable pregnancies, 19 (36.5%) decided to retain their pregnancies, while 33 (63.5%) decided not to retain their pregnancies. Conclusion: Almost 40% of clients presenting as pre abortion clients decided to retain the pregnancy. This work also once again highlights the high unmet need for contraception in Nigeria.
背景:消除伤害模式的目的是改善获得堕胎前和堕胎后护理的机会,包括免费避孕,并解决不安全堕胎对参与研究的妇女的性健康和生殖健康构成的挑战。目的:确定“尼日利亚不安全堕胎危害消除项目”(HELPUSAN)模式对寻求终止妊娠的妇女决定继续妊娠的比率的影响以及决定这一决定的因素。对象和方法:在6个月的试点调查期间,根据研究方案,为所有堕胎妇女提供堕胎前和堕胎后的咨询和服务。该研究没有根据尼日利亚的堕胎法提供堕胎服务。随访6周,评估患者是否决定继续妊娠。结果:105名参与者中,12.4%的人拒绝报名,59.8%的人人工流产,45.8%的人自然流产。在人工流产后就诊的患者中,药物是诱导流产过程的主要方法(80.5%)。共有90例(97.8%)被证实怀孕,其中52例(57.8%)存活。此外,在52名有妊娠能力的参与者中,19人(36.5%)决定继续妊娠,33人(63.5%)决定不继续妊娠。结论:近40%的流产前患者决定保留妊娠。这项工作也再次突出了尼日利亚未满足的避孕需求。
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引用次数: 1
A 5-year audit of diagnostic gynaecologic laparoscopy under conscious sedation at the university college hospital, Ibadan 伊巴丹大学学院医院在清醒镇静下诊断妇科腹腔镜检查的5年审计
Pub Date : 2019-01-01 DOI: 10.4103/TJOG.TJOG_15_18
O. Adesina, G. O. Obajimi, T. Abo-Briggs
Introduction: Diagnostic laparoscopy affords smaller incisions, shorter recovery time, and fewer complications. In developing countries, access is limited by cost, infrastructural deficit, and expertise. In a bid to reduce cost at our center, conscious sedation for diagnostic laparoscopy was introduced as far back as 1980. We present here a 5-year audit of our outpatient diagnostic laparoscopy highlighting the various indications, findings, and complications observed. Methodology: A retrospective review of case files of patients who had diagnostic gynecological laparoscopy between 1st January 2011 and 31st December 2015. The retrieved case files had data extracted and analysed using the Statistical Package for Social Sciences version 20 (Chicago IL USA). Data was presented as simple percentages using tables and figures. Results: During the period, 1,329 outpatient gynecological procedures were performed with 207 diagnostic gynecologic laparoscopies (15.6%). Only 187 case notes were retrieved (retrieval rate of 90%). The mean age was 33.04 (±5.2) years, 84.5% (158) had post-secondary education, and 69.0% (129) were nulliparous. Majority, 131 (70.0%), had laparoscopy and dye test, 26 (14.0%) had laparoscopy alone, and 30 (16.0%) had a combination of laparoscopy, dye test, and hysteroscopy. The commonest indications were secondary infertility (51.9%), primary infertility (24.1%), and chronic pelvic pain (11.2%). Common findings at laparoscopy were pelvic adhesions (53.5%), uterine fibroids (35.1%), and bilateral tubal blockage (30.3%). Normal findings were reported in only 19 patients (10.3%). Conclusion: Diagnostic laparoscopy under conscious sedation is cost-effective and safe. It has very minimal complications when performed by skilled personnel. It is thus recommended for low resource settings with the view to avail low income patients the opportunity for endoscopic evaluation.
引言:诊断性腹腔镜手术切口更小,恢复时间更短,并发症更少。在发展中国家,准入受到成本、基础设施赤字和专业知识的限制。早在1980年,为了降低我们中心的成本,诊断性腹腔镜手术就引入了清醒镇静。我们在这里对我们的门诊诊断腹腔镜检查进行了5年的审计,强调了观察到的各种适应症、发现和并发症。方法:对2011年1月1日至2015年12月31日期间进行妇科腹腔镜诊断的患者的病例档案进行回顾性审查。检索到的病例档案使用社会科学统计包第20版(美国伊利诺伊州芝加哥)提取并分析了数据。数据是用表格和数字以简单的百分比表示的。结果:在此期间,门诊妇科手术1329例,妇科诊断腹腔镜207例(15.6%),仅检索到187例病例记录(检索率为90%)。平均年龄为33.04(±5.2)岁,84.5%(158)受过中学后教育,69.0%(129)未产妇。大多数患者,131人(70.0%)进行了腹腔镜检查和染色检查,26人(14.0%)单独进行了腹腔镜手术,30人(16.0%)同时进行了腹腔镜、染色检查和宫腔镜检查。最常见的指征是继发性不孕(51.9%)、原发性不孕(24.1%)和慢性盆腔疼痛(11.2%)。腹腔镜检查的常见表现是盆腔粘连(53.5%)、子宫肌瘤(35.1%)和双侧输卵管堵塞(30.3%)。只有19名患者(10.3%)报告了正常表现。结论:清醒镇静下的诊断性腹腔镜检查成本效益高且安全。由熟练的人员进行操作时,并发症非常小。因此,建议将其用于低资源环境,以期为低收入患者提供内镜评估的机会。
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引用次数: 2
Maternal determinants and fetal outcome of multifetal pregnancies in Ahmadu Bello University Teaching Hospital, Zaria, Nigeria 尼日利亚扎里亚Ahmadu Bello大学教学医院多胎妊娠的母体决定因素和胎儿结局
Pub Date : 2019-01-01 DOI: 10.4103/TJOG.TJOG_75_18
S. Adelaiye, H. Adelaiye, P. Onwuhafua
Background: Multifetal pregnancies remain a challenge to both parents and clinicians. With the increasing application of assisted reproductive technology in infertility management, the incidence is likely to continue to rise. Aim and Objective: To determine maternal characteristics of multifetal pregnancies, maternal and fetal outcomes, at the Ahmadu Bello University Teaching Hospital (ABUTH), Nigeria. Patients and Methods: A retrospective observational study of women who had multifetal pregnancy in ABUTH Zaria over a period of 5 years was conducted. Information regarding maternal determinants and fetal outcome was collated. The data were analyzed using SPSS version 20.0. Demographic variables were presented using tables and figures, while summaries were done using means, standard deviation, and percentages. Test of association was done using Chi-square. P value <0.05 was considered statistically significant. Results: The total number of deliveries during the study period was 9399 out of which 254 were twins and 2 were higher order multifetal pregnancies. Giving us a rate of 27/1000 multifetal deliveries, majority of the women were booked (91%) and the average number of antenatal visits was 7.4 ± 3.1. The mean maternal age was 29 ± 6 and the mean parity was 2.4 ± 2.2. The mean gestational age at delivery was 36.5 ± 2.2. History of ovulation induction was present in 33% and 57% gave a family history of twinning. The Yoruba ethnic group had the highest incidence with 42.7%. A total of 19% were admitted for various indications, the commonest indication was hypertensive disorders (18%), 64% of the women had preterm deliveries, and 7.5% of the women delivered before 34 weeks. The caesarean section (CS) rate was 39.7%. The commonest presentation was cephalic. There was statistical significant difference between presentation and mode of delivery X2 = 31.579 and P = 0.000. The mean birth weight of T1= 2.3 ± 0.5, and that of T2= 2.7 ± 3, and 68.3% of T1 compared to 60.2% of T2 had weight <2.5 kg. There was statistically significant difference between the mean birth weight and Apgar score of the leading fetuses P = 0.009. Up to 92.6% of T1 were delivered alive, compared to 84.6% of T2, Mean interbaby delivery interval between T1 and T2 was 11.7 minutes. Male:female ratio was 1:1.1. A total of 23% were admitted to neonatal intensive care unit and the commonest indication for admission was low birth weight (35%). The commonest causes of perinatal mortality were asphyxia and sepsis. Perinatal mortality was 114 per 1000 births and maternal mortality rate was 1,639/100,000 live births. Conclusion: Parity, ethnicity, maternal age, ovulation induction, and family history were the major determinants of multifetal pregnancies. There was association between presentation and mode of delivery and also the birth weight and Apgar score of the leading twins. Our multifetal pregnancy rate and cesarean section rate were high, associated with high maternal and perinatal mor
背景:多胎妊娠对父母和临床医生来说仍然是一个挑战。随着辅助生殖技术在不孕不育管理中的应用越来越多,发病率可能会继续上升。目的和目的:在尼日利亚艾哈迈杜·贝洛大学教学医院(ABUTH)确定多胎妊娠的母体特征、母体和胎儿结局。患者和方法:对ABUTH Zaria多胎妊娠妇女进行了为期5年的回顾性观察研究。对有关母体决定因素和胎儿结局的信息进行了整理。使用SPSS 20.0版对数据进行分析。人口统计变量采用表格和数字表示,总结采用平均值、标准差和百分比。关联性检验采用卡方检验。P值<0.05被认为具有统计学意义。结果:研究期间的分娩总数为9399例,其中254例为双胞胎,2例为高位多胎妊娠。根据我们的多胎分娩率为27/1000,大多数女性(91%)已预约,平均产前检查次数为7.4±3.1次。平均产妇年龄为29±6岁,平均产次为2.4±2.2次。分娩时的平均胎龄为36.5±2.2。33%有促排卵史,57%有双胞胎家族史。约鲁巴族的发病率最高,为42.7%。共有19%的患者因各种适应症入院,最常见的适应症是高血压疾病(18%),64%的女性早产,7.5%的女性在34周前分娩。剖腹产(CS)的发生率为39.7%,最常见的表现是头部畸形。表现和分娩方式之间有统计学意义的差异X2=31.579和P=0.000。T1的平均出生体重为2.3±0.5,T2的平均出生重量为2.7±3,68.3%的T1和60.2%的T2体重<2.5 kg。领先胎儿的平均出生质量和Apgar评分之间存在统计学显著差异P=0.009。高达92.6%的T1存活分娩,而T2存活分娩的比例为84.6%。T1和T2之间的平均婴儿间分娩间隔为11.7分钟。男女比例为1:1.1。共有23%的新生儿入住新生儿重症监护室,最常见的入院指征是低出生体重(35%)。围产期死亡最常见的原因是窒息和败血症。围产期死亡率为114‰,产妇死亡率为1639/100000活产。结论:胎次、种族、产妇年龄、促排卵和家族史是多胎妊娠的主要决定因素。表现和分娩方式以及领先双胞胎的出生体重和Apgar评分之间存在关联。我们的多胎妊娠率和剖宫产率很高,与高孕产妇和围产期发病率和死亡率相关。
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引用次数: 1
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Tropical Journal of Obstetrics and Gynaecology
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