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Determinants and outcomes of elective and emergency caesarean section at a tertiary hospital in Abakaliki, Southeast Nigeria: A 6-year review 尼日利亚东南部阿巴卡利基一家三级医院选择性和紧急剖腹产的决定因素和结果:6年回顾
Pub Date : 2019-09-17 DOI: 10.4103/TJOG.TJOG_19_19
O. Asiegbu, U. Asiegbu, E. Mamah, C. Anikwe, O. Ogah, U. Nnadozie
Background: Despite its increasing acceptance as a safe alternative to vaginal delivery, caesarean section (CS) in developing countries continue to be associated with maternal and fetal morbidity and mortality. Objectives: This study was aimed at evaluating the indications, outcomes and factors associated with increased CS at the Federal Teaching Hospital, Abakaliki. Methods: This was a six year retrospective study covering 2012 to 2017. Case notes of patients were identified and retrieved from the records unit of the hospital. Information extracted include sociodemographic variables, indications and types of CS performed and the complications. These data were entered into a personal computer and analysed with Epi Info version 7. Results: These were presented using tables and percentages. A p-value of 0.05 was considered significant. In 6 years, 11,215 women were delivered, 2405 (21.4%) had emergency CS while 1445 (12.9%) had elective CS; giving a CS rate of 34.3%. The most common indication for emergency CS was cephalopelvic disproportion (22.0%) while previous caesarean section (27.7%) formed the major indication for elective CS. Severe birth asphyxia was recorded in 17.2% and 4.2% of babies delivered by emergency and elective CS respectively. Booking status, parity and patient's age had statistically significant association with the chance of having a CS. Maternal and perinatal deaths were recorded in 2.6% and 5.0% for emergency CS compared to 1.0% and 0.2% for elective CS. Although lifesaving, CS, due to an existing condition or complication in the patient, may be associated with an increase in maternal and fetal morbidities and mortalities. Conclusion: There was a higher burden of complication with emergency CS due to its associated determinants. Adequate training of healthcare personnel on ways of minimizing complications against the backdrop of an existing problem and an efficient referral system will help reduce these morbidities and mortalities.
背景:尽管剖腹产作为阴道分娩的安全替代品越来越被接受,但在发展中国家,剖腹产仍然与孕产妇和胎儿的发病率和死亡率有关。目的:本研究旨在评估阿巴卡利基联邦教学医院CS增加的适应症、结果和相关因素。方法:这是一项为期六年的回顾性研究,涵盖2012年至2017年。患者的病例记录已被确认,并从医院的记录单元中检索。提取的信息包括社会人口统计学变量、CS的适应症和类型以及并发症。将这些数据输入个人电脑,并使用Epi Info第7版进行分析。结果:这些是用表格和百分比表示的。0.05的p值被认为是显著的。在6年内,11215名妇女分娩,2405名(21.4%)接受了急诊CS,1445名(12.9%)接受选择性CS;CS发生率为34.3%。紧急CS最常见的指征是头盆不平衡(22.0%),而之前的剖腹产(27.7%)是选择性CS的主要指征。急诊分娩和选择性CS分娩的婴儿中,严重出生窒息的发生率分别为17.2%和4.2%。预订状态、产次和患者年龄与CS的发生率具有统计学意义。急诊CS记录的孕产妇和围产期死亡分别为2.6%和5.0%,而选择性CS记录的为1.0%和0.2%。虽然CS可以挽救生命,但由于患者现有的疾病或并发症,CS可能与母体和胎儿疾病和死亡率的增加有关。结论:急诊CS的相关决定因素使其并发症负担更高。在现有问题的背景下,对医护人员进行充分的培训,以尽量减少并发症,并建立有效的转诊系统,这将有助于减少这些疾病和死亡率。
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引用次数: 4
Effect of honey and intensity of swimming exercise on semen parameters of male albino Wistar rats 蜂蜜及游泳运动强度对雄性白化Wistar大鼠精液参数的影响
Pub Date : 2019-09-17 DOI: 10.4103/TJOG.TJOG_5_19
HM Abdullahi, MK Atiku, Y. Abdulmumin, WH Sadiya
Background: The impairment of male fertility has been linked to exercise in a volume-, intensity-, and modality-dependent manner. Infertility is a worldwide problem and male factor infertility is found to be increased. Chronic administration of honey results in elevating sorbitol dehydrogenase activity and decreases lactose dehydrogenase activity, which was found to be in abundance in spermatids and spermatozoa, and a decrease in this enzyme significantly affects the semen parameters and decreases ATP synthesis due to oxidative stress. Objective: The study aimed to evaluate the effect of honey and intensity of swimming exercise on semen parameters of male albino Wistar rats. Methodology: A randomized control trial study was adopted involving 50 sexually mature male Wistar rats (180 ± 20 g). The selected rats were divided into five groups of 10 rats each: group I served as normal control while group II was induced with honey only and served as study control. Groups III–V were study groups induced orally with 7.5 mL/kg of honey twice per week for 8 weeks and exposed to mild, moderate, and high-intensity swimming exercises 5 days/week for 8 weeks, respectively. Results: Chronic oral administration of pure honey showed that motility, viability, sperm count, and semen morphology were significantly lower, and percentages of abnormal morphology were found to be significantly higher (P < 0.05) in group II compared with normal control rats (group I). There was a significant decrease in motility, viability, and morphology in group V when compared with groups I, III, and IV. However, they were significantly higher when compared with test control group. The decrease was found to be swimming exercise time-dependent. Conclusion: Chronic consumption of pure honey has a deleterious effect on semen parameters, and mild, moderate, and intensity swimming exercises were found to have a positive effect of induced semen parameters of male albino Wistar rats.
背景:男性生育能力的损害与运动量、强度和运动方式有关。不育症是一个世界性的问题,男性因素导致的不育症越来越多。长期服用蜂蜜导致山梨糖醇脱氢酶活性升高,乳糖脱氢酶活性降低,该酶在精子和精子中大量存在,并且该酶的降低显著影响精液参数,并减少氧化应激引起的ATP合成。目的:探讨蜂蜜和游泳运动强度对雄性白化Wistar大鼠精液参数的影响。方法:采用随机对照试验方法,选取性成熟雄性Wistar大鼠50只(180±20 g),随机分为5组,每组10只,ⅰ组为正常对照组,ⅱ组仅用蜂蜜诱导为研究对照组。III-V组为每周2次口服7.5 mL/kg蜂蜜诱导,持续8周,并分别进行轻度、中度和高强度游泳运动,每周5天,持续8周。结果:长期口服纯蜂蜜组大鼠活力、活力、精子数量、精液形态明显低于正常对照组(ⅰ组),形态异常率显著高于正常对照组(ⅰ组)(P < 0.05)。V组大鼠活力、活力、形态明显低于ⅰ、ⅲ、ⅳ组(P < 0.05),但高于试验对照组(P < 0.05)。研究发现,这种下降与游泳锻炼的时间有关。结论:长期饮用纯蜂蜜对雄性白化Wistar大鼠的精液参数有不利影响,轻度、中度和强度游泳运动对雄性白化Wistar大鼠的精液参数有积极影响。
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引用次数: 1
Pattern of birth defects at a university teaching hospital in Northern Nigeria: Retrospective review over a decade 尼日利亚北部一所大学教学医院的出生缺陷模式:十多年来的回顾性审查
Pub Date : 2019-09-17 DOI: 10.4103/TJOG.TJOG_28_19
I. Takai, S. Gaya, M. Sheu, M. Abdulsalam
Background: Major birth defects are common causes of perinatal morbidity and mortality which have become a global phenomenon. Its occurrence in the developing nations like Nigeria requires due consideration most especially to its pattern and risk factors. Objectives: This review was conducted to determine the pattern of birth defects and investigate the factors associated with birth defects and its outcome at Aminu Kano Teaching Hospital (AKTH), Kano. Methods: This was a 10-year retrospective study conducted in the Department of Obstetrics and Gynaecology and the Department of Paediatrics (Special Care Baby Unit) of AKTH, Kano, between April 2007 and March 2017. Data retrieved from patients' file were collected using a purpose-designed proforma to obtain information on the required parameters and analyzed using IBM SPSS version 20, 2009 software. Frequencies and percentages were calculated and the results were presented in tabular forms. Results: There were 6990 deliveries within the study period, out of which 305 babies had birth defects, giving a prevalence of 4.4%. Among women who delivered baby with birth defects, maternal age ranged from 16 to 45 years with a mean age of 30 ± 5 years. The highest incidence (48%) of birth defects occurred among the 26–35 years age group. Anomalies that affected single system are significantly higher than anomalies that affected multiple systems. A higher percentage (52.5%) of birth defects occurred in male neonates. The gastrointestinal system was the most commonly affected (32.5%), while musculoskeletal system was the least (3.75%) affected system. Drug intake among 120 mothers who delivered neonates with birth defects when considered as a risk factor was found to constitute 81% of traditional concoction/herbs; while 12.5% were orthodox and intake of social drug was found to be only 6.5%. Hypertension was found to be the highest chronic medical disorder, while chorioamnionitis following premature rupture of membrane was recorded as the most commonly occurring maternal infection. Sixty percent of these neonates with birth defects were managed conservatively, surgical treatment was given in 23.5%, while 16.5% underwent medical treatment. Discharge rate was 82.5%; 9% left against medical advice, while neonatal mortality rate was about 8.5% and a majority (91.8%) of the death occurred among the neonates with multiple birth defects. Conclusion: The prevalence of birth defect in AKTH was 4.4% of the total deliveries over the study period. Gastrointestinal system was found to be the most commonly affected system. Hypertensive disorders of pregnancy and ingestion of traditional herbs were found to be the most common medical disorder and drug intake, respectively, among the mothers who delivered neonates with birth defects. Although the outcome of the management was good, and the study could not establish direct causation, there is need to counsel mothers on the inherent dangers of traditional herbs ingestion and the
背景:重大出生缺陷是围产期发病率和死亡率的常见原因,已成为一种全球性现象。它在尼日利亚等发展中国家的发生需要充分考虑,尤其是其模式和风险因素。目的:本综述旨在确定卡诺Aminu Kano教学医院(AKTH)的出生缺陷模式,并调查与出生缺陷及其结果相关的因素。方法:这是一项为期10年的回顾性研究,于2007年4月至2017年3月在卡诺州AKTH的妇产科和儿科(特殊护理婴儿室)进行。使用专门设计的形式表收集从患者档案中检索的数据,以获得所需参数的信息,并使用IBM SPSS 2009版软件进行分析。计算了频率和百分比,结果以表格形式呈现。结果:研究期间共有6990次分娩,其中305名婴儿有出生缺陷,患病率为4.4%。在分娩有出生缺陷婴儿的妇女中,母亲年龄从16岁到45岁不等,平均年龄为30±5岁。出生缺陷的发生率最高(48%)发生在26-35岁年龄组。影响单个系统的异常明显高于影响多个系统的异常。出生缺陷发生在男性新生儿中的比例较高(52.5%)。胃肠系统受影响最为常见(32.5%),而肌肉骨骼系统受影响最小(3.75%)。在120名分娩有出生缺陷新生儿的母亲中,当被视为一个危险因素时,药物摄入占传统混合物/草药的81%;高血压是最高的慢性疾病,而膜早破后的绒毛膜羊膜炎是最常见的母体感染。这些有出生缺陷的新生儿中,60%得到了保守治疗,23.5%接受了手术治疗,16.5%接受了药物治疗。出院率82.5%;9%的新生儿不听医嘱,而新生儿死亡率约为8.5%,大多数(91.8%)死亡发生在有多个出生缺陷的新生儿中。结论:在研究期间,AKTH的出生缺陷发生率占总分娩量的4.4%。胃肠系统被发现是最常见的受影响系统。妊娠期高血压疾病和服用传统草药分别是分娩有出生缺陷新生儿的母亲中最常见的医疗疾病和药物摄入。尽管治疗结果良好,研究也无法确定直接原因,但有必要就摄入传统草药的固有危险以及对妊娠期医疗状况给予足够关注的必要性向母亲提供建议。
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引用次数: 4
Correlation between transabdominal ultrasound features of ectopic gestation and surgical findings at the university college hospital, Ibadan: A preliminary review 伊巴丹大学学院医院异位妊娠经腹超声特征与手术结果的相关性:初步综述
Pub Date : 2019-09-17 DOI: 10.4103/TJOG.TJOG_39_18
G. Obajimi, A. Smart, A. Adekanmi, A. Adeniji-Sofoluwe, F. Jinadu
Introduction: Ectopic pregnancy in Sub-Saharan Africa has an incidence of 1%-5% of all deliveries and 5%-10% of all gynaecological admissions. The fallopian tube is the most common site of occurrence of an ectopic pregnancy and ruptured ectopic is the commonest variety seen in low resource settings. Materials and Method: This is a 2-year retrospective diagnostic accuracy test of transabdominal ultrasonographic findings in ectopic pregnancy, using surgical findings as the gold-standard. The study was conducted at the Radiology Department of the University College Hospital, Ibadan, Nigeria between 1 January 2013 and 31 December 2014. Radiological request cards of 41 women who were clinically suspected to have an ectopic pregnancy and had a transabdominal ultrasound scan were retrieved, however, only 34 were suitable for analysis. Data analysis was done using the Statistical Package for Social Sciences (SPSS) version 20 (Chicago, IL, USA). A P value of <0.05 was regarded as statistically significant. Results: The ages of the women ranged between 20 and 40 years with a mean age of 29.94 ± 5.06 years. The mean gestational age at time of scan was 44.8 days (6 weeks + 3 days). Out of 34 patients reviewed in this study, 29 had surgical interventions in the course of their management and 26 had ectopic gestation confirmed at surgery. This study found a Sensitivity of 88.4%, Specificity of 37.5% and Positive and Negative predictive values of 82.1% and 50%, respectively. Conclusion: This preliminary study suggests that transabdominal ultrasonography is a useful and reliable means of diagnosing ectopic pregnancy particularly in low-resource settings where availability and or technical skill for transvaginal ultrasonography is not readily available.
引言:在撒哈拉以南非洲,异位妊娠的发生率为所有分娩的1%-5%,占所有妇科住院的5%-10%。输卵管是发生异位妊娠最常见的部位,在资源贫乏的环境中,异位破裂是最常见的。材料和方法:本研究以手术结果为金标准,对经腹超声检查异位妊娠的诊断准确性进行了为期2年的回顾性研究。该研究于2013年1月1日至2014年12月31日在尼日利亚伊巴丹大学学院医院放射科进行。41例临床怀疑异位妊娠并经腹部超声扫描的妇女的放射要求卡被检索,然而,只有34例适合分析。数据分析使用社会科学统计软件包(SPSS)版本20(芝加哥,伊利诺伊州,美国)完成。P值<0.05为差异有统计学意义。结果:女性年龄20 ~ 40岁,平均29.94±5.06岁。扫描时平均胎龄44.8天(6周+ 3天)。在本研究中回顾的34例患者中,29例在治疗过程中接受了手术干预,26例在手术中证实了异位妊娠。本研究发现敏感性为88.4%,特异性为37.5%,阳性预测值和阴性预测值分别为82.1%和50%。结论:这项初步研究表明,经腹超声检查是诊断异位妊娠的一种有用和可靠的手段,特别是在资源匮乏的环境中,不容易获得经阴道超声检查的可用性和/或技术技能。
{"title":"Correlation between transabdominal ultrasound features of ectopic gestation and surgical findings at the university college hospital, Ibadan: A preliminary review","authors":"G. Obajimi, A. Smart, A. Adekanmi, A. Adeniji-Sofoluwe, F. Jinadu","doi":"10.4103/TJOG.TJOG_39_18","DOIUrl":"https://doi.org/10.4103/TJOG.TJOG_39_18","url":null,"abstract":"Introduction: Ectopic pregnancy in Sub-Saharan Africa has an incidence of 1%-5% of all deliveries and 5%-10% of all gynaecological admissions. The fallopian tube is the most common site of occurrence of an ectopic pregnancy and ruptured ectopic is the commonest variety seen in low resource settings. Materials and Method: This is a 2-year retrospective diagnostic accuracy test of transabdominal ultrasonographic findings in ectopic pregnancy, using surgical findings as the gold-standard. The study was conducted at the Radiology Department of the University College Hospital, Ibadan, Nigeria between 1 January 2013 and 31 December 2014. Radiological request cards of 41 women who were clinically suspected to have an ectopic pregnancy and had a transabdominal ultrasound scan were retrieved, however, only 34 were suitable for analysis. Data analysis was done using the Statistical Package for Social Sciences (SPSS) version 20 (Chicago, IL, USA). A P value of <0.05 was regarded as statistically significant. Results: The ages of the women ranged between 20 and 40 years with a mean age of 29.94 ± 5.06 years. The mean gestational age at time of scan was 44.8 days (6 weeks + 3 days). Out of 34 patients reviewed in this study, 29 had surgical interventions in the course of their management and 26 had ectopic gestation confirmed at surgery. This study found a Sensitivity of 88.4%, Specificity of 37.5% and Positive and Negative predictive values of 82.1% and 50%, respectively. Conclusion: This preliminary study suggests that transabdominal ultrasonography is a useful and reliable means of diagnosing ectopic pregnancy particularly in low-resource settings where availability and or technical skill for transvaginal ultrasonography is not readily available.","PeriodicalId":23302,"journal":{"name":"Tropical Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47130926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Misoprostol versus oxytocin in preventing postpartum hemorrhage: A randomized controlled trial 米索前列醇与催产素预防产后出血的随机对照试验
Pub Date : 2019-09-17 DOI: 10.4103/TJOG.TJOG_16_19
O. Owa, A. Lemadoro, B. Temenu, J. Ayeyemi, O. Loto
Objective: To compare low dose sublingual misoprostol with the standard 10 IU of intramuscular oxytocin in active management of third stage of labor. Materials and Methods: A total of 104 women with term pregnancy were randomized to receive either 200 μg misoprostol sublingually or 10 IU oxytocin intramuscularly after vaginal delivery. Primary outcome measured was mean blood loss and incidence of primary postpartum hemorrhage (PPH). Secondary outcome measured included duration of third stage of labor, side effects of drugs and need for additional oxytocics to treat life-threatening hemorrhage. Results: A total of 104 women with term pregnancy in two groups of 52 were studied. The mean blood loss with sublingual misoprostol and oxytocin groups was 320.58 ± 244.12 vs. 253.27 ± 171.74 ml; P = 0.11. There was no significant differences between the misoprostol and oxytocin groups with regard to the incidence of PPH (19.2% vs. 13.5% respectively; P = 0.43). More women in the misoprostol group experienced side effects compared with those in oxytocin group; however, the difference was not statistically significant (P = 0.26). The mean duration of third stage of labor was similar and the difference was statistically not significant (6.65 ± 3.47 vs. 6.08 ± 3.07 minutes) (P = 0.38), as well as need for additional oxytocics (13.5% vs. 5.8% P = 0.18) misoprostol and oxytocin, respectively. Conclusion: Sublingual misoprostol has similar efficacy to standard intramuscular oxytocin in preventing PPH following vaginal birth. Misoprostol at 200 μg with its thermostability may be an effective alternative to intramuscular oxytocin in active management of third stage of labor.
目的:比较低剂量舌下米索前列醇与标准10 IU肌内催产素在第三产褥期积极治疗中的作用。材料与方法:104例足月妊娠妇女阴道分娩后随机接受200 μg米索前列醇舌下或10 IU催产素肌内注射。主要观察指标为平均失血量和原发性产后出血(PPH)发生率。测量的次要结果包括第三产程持续时间、药物的副作用以及是否需要额外的催产素来治疗危及生命的出血。结果:共对104例足月妊娠妇女分为两组,每组52例。米索前列醇组和催产素组的平均失血量分别为320.58±244.12 ml和253.27±171.74 ml;P = 0.11。米索前列醇组和催产素组在PPH发生率方面无显著差异(分别为19.2%和13.5%;P = 0.43)。与催产素组相比,米索前列醇组有更多的女性出现了副作用;但差异无统计学意义(P = 0.26)。第三产程平均持续时间相似,差异无统计学意义(6.65±3.47 vs 6.08±3.07 min) (P = 0.38),以及需要额外使用的催产素(13.5% vs 5.8% P = 0.18)米索前列醇和催产素(P = 0.18)。结论:舌下米索前列醇预防阴道分娩后PPH的效果与标准肌内催产素相似。米索前列醇200 μg的热稳定性可能是肌注催产素在第三产褥期积极管理的有效替代。
{"title":"Misoprostol versus oxytocin in preventing postpartum hemorrhage: A randomized controlled trial","authors":"O. Owa, A. Lemadoro, B. Temenu, J. Ayeyemi, O. Loto","doi":"10.4103/TJOG.TJOG_16_19","DOIUrl":"https://doi.org/10.4103/TJOG.TJOG_16_19","url":null,"abstract":"Objective: To compare low dose sublingual misoprostol with the standard 10 IU of intramuscular oxytocin in active management of third stage of labor. Materials and Methods: A total of 104 women with term pregnancy were randomized to receive either 200 μg misoprostol sublingually or 10 IU oxytocin intramuscularly after vaginal delivery. Primary outcome measured was mean blood loss and incidence of primary postpartum hemorrhage (PPH). Secondary outcome measured included duration of third stage of labor, side effects of drugs and need for additional oxytocics to treat life-threatening hemorrhage. Results: A total of 104 women with term pregnancy in two groups of 52 were studied. The mean blood loss with sublingual misoprostol and oxytocin groups was 320.58 ± 244.12 vs. 253.27 ± 171.74 ml; P = 0.11. There was no significant differences between the misoprostol and oxytocin groups with regard to the incidence of PPH (19.2% vs. 13.5% respectively; P = 0.43). More women in the misoprostol group experienced side effects compared with those in oxytocin group; however, the difference was not statistically significant (P = 0.26). The mean duration of third stage of labor was similar and the difference was statistically not significant (6.65 ± 3.47 vs. 6.08 ± 3.07 minutes) (P = 0.38), as well as need for additional oxytocics (13.5% vs. 5.8% P = 0.18) misoprostol and oxytocin, respectively. Conclusion: Sublingual misoprostol has similar efficacy to standard intramuscular oxytocin in preventing PPH following vaginal birth. Misoprostol at 200 μg with its thermostability may be an effective alternative to intramuscular oxytocin in active management of third stage of labor.","PeriodicalId":23302,"journal":{"name":"Tropical Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43656201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Maternal side effects of efavirenz-containing highly active antiretroviral therapy (HAART): A comparative study of HIV-positive pregnant and nonpregnant women in a tertiary hospital 含依非韦伦的高效抗逆转录病毒治疗(HAART)的产妇副作用:三级医院hiv阳性孕妇和非孕妇的比较研究
Pub Date : 2019-09-17 DOI: 10.4103/TJOG.TJOG_1_19
K. Makinde, B. Okusanya, OR Akinajo
Background: Efavirenz is now a first-line non-nucleoside reverse transcriptase inhibitor used as highly active antiretroviral therapy (HAART) though its use is fraught with maternal side effects, usually of the central nervous system (CNS) and fetal complications. Objective: The study aims to comparatively document the maternal side-effect profile of an efavirenz-containing fixed-dosage HAART and compliance with its use in HIV-positive pregnant and nonpregnant women at the Lagos University Teaching Hospital (LUTH), Idi-Araba. Methodology: A prospective study among HIV-positive pregnant (40) and nonpregnant women (40) on efavirenz-containing fixed-dose HAART (Atripla®) who were recruited purposively at the antenatal clinic and AIDS Prevention Initiative Nigeria (APIN) clinics of LUTH. Data analysis was done with EPI Info 2014, and the results are presented in frequencies. Results: The mean age of respondents was 31 ± 5.7 years. Atripla® was the only fixed-dose combination used. Fifty-three percent and 62.5% of pregnant and nonpregnant HIV-positive women, respectively, reported CNS side effects of Atripla® [odds ratio: 0.66, 95% confidence interval 0.27–1.62]. Adherence to the use of Atripla® was 100% among HIV-positive pregnant women. Women with baseline viral load values greater than 400 copies/mL reported more side effects to Atripla®. Conclusion: There are similar side-effect profiles of Atripla® in HIV-positive women irrespective of pregnancy. Education and counselling can help foster adherence, resulting in improved immunological and virological outcome.
背景:Efavirenz目前是一线非核苷类逆转录酶抑制剂,用于高效抗逆转录病毒治疗(HAART),尽管其使用充满了母体副作用,通常是中枢神经系统(CNS)和胎儿并发症。目的:本研究旨在比较记录在拉各斯大学教学医院(LUTH),含有依非韦伦的一种固定剂量HAART药物的产妇副作用及其在艾滋病毒阳性孕妇和非孕妇中的使用依从性。方法:一项前瞻性研究,在hiv阳性孕妇(40名)和非孕妇(40名)中进行含依非韦伦的固定剂量HAART治疗(Atripla®),这些孕妇是在LUTH的产前诊所和艾滋病预防倡议尼日利亚(APIN)诊所有目的招募的。数据分析使用EPI Info 2014进行,结果以频率表示。结果:调查对象平均年龄31±5.7岁。Atripla®是唯一使用的固定剂量组合。妊娠期和非妊娠期hiv阳性妇女分别有53%和62.5%报告了Atripla®的中枢神经系统副作用[优势比:0.66,95%可信区间0.27-1.62]。在hiv阳性孕妇中,Atripla®的使用依从性为100%。基线病毒载量值大于400拷贝/mL的女性报告了Atripla®的更多副作用。结论:Atripla®在hiv阳性妇女中存在相似的副作用。教育和咨询可以帮助促进依从性,从而改善免疫和病毒学结果。
{"title":"Maternal side effects of efavirenz-containing highly active antiretroviral therapy (HAART): A comparative study of HIV-positive pregnant and nonpregnant women in a tertiary hospital","authors":"K. Makinde, B. Okusanya, OR Akinajo","doi":"10.4103/TJOG.TJOG_1_19","DOIUrl":"https://doi.org/10.4103/TJOG.TJOG_1_19","url":null,"abstract":"Background: Efavirenz is now a first-line non-nucleoside reverse transcriptase inhibitor used as highly active antiretroviral therapy (HAART) though its use is fraught with maternal side effects, usually of the central nervous system (CNS) and fetal complications. Objective: The study aims to comparatively document the maternal side-effect profile of an efavirenz-containing fixed-dosage HAART and compliance with its use in HIV-positive pregnant and nonpregnant women at the Lagos University Teaching Hospital (LUTH), Idi-Araba. Methodology: A prospective study among HIV-positive pregnant (40) and nonpregnant women (40) on efavirenz-containing fixed-dose HAART (Atripla®) who were recruited purposively at the antenatal clinic and AIDS Prevention Initiative Nigeria (APIN) clinics of LUTH. Data analysis was done with EPI Info 2014, and the results are presented in frequencies. Results: The mean age of respondents was 31 ± 5.7 years. Atripla® was the only fixed-dose combination used. Fifty-three percent and 62.5% of pregnant and nonpregnant HIV-positive women, respectively, reported CNS side effects of Atripla® [odds ratio: 0.66, 95% confidence interval 0.27–1.62]. Adherence to the use of Atripla® was 100% among HIV-positive pregnant women. Women with baseline viral load values greater than 400 copies/mL reported more side effects to Atripla®. Conclusion: There are similar side-effect profiles of Atripla® in HIV-positive women irrespective of pregnancy. Education and counselling can help foster adherence, resulting in improved immunological and virological outcome.","PeriodicalId":23302,"journal":{"name":"Tropical Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41561850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endometriosis with massive recurrent hemorrhagic ascites: A case report 子宫内膜异位症合并大量复发性出血性腹水1例
Pub Date : 2019-09-17 DOI: 10.4103/TJOG.TJOG_9_19
E. N’guessan, N. Kouamé, F. Gbeli, P. Guié
Ascites is a rare manifestation of endometriosis. The case reported is that of a 26-year-old woman with recurrent massive hemorrhagic ascites. The analysis of biopsy specimens made at laparoscopy confirmed the diagnosis. The report noted pelvic endometriosis associated but there was no umbilical or pleural involvement. The evolution was favorable under a long term hormone treatment (by GnRH analogues) with relay through continuous estrogen-progestogen. The diagnostic and therapeutic difficulties of this rare form of endometriosis are presented through a review of the literature.
腹水是子宫内膜异位症的罕见表现。病例报告是一个26岁的妇女复发性大出血腹水。腹腔镜下活检标本的分析证实了诊断。报告指出盆腔子宫内膜异位症相关,但没有脐带或胸膜受累。在长期激素治疗(GnRH类似物)下,通过持续的雌激素-孕激素进行中继,这种进化是有利的。诊断和治疗的困难,这种罕见形式的子宫内膜异位症是通过回顾文献提出。
{"title":"Endometriosis with massive recurrent hemorrhagic ascites: A case report","authors":"E. N’guessan, N. Kouamé, F. Gbeli, P. Guié","doi":"10.4103/TJOG.TJOG_9_19","DOIUrl":"https://doi.org/10.4103/TJOG.TJOG_9_19","url":null,"abstract":"Ascites is a rare manifestation of endometriosis. The case reported is that of a 26-year-old woman with recurrent massive hemorrhagic ascites. The analysis of biopsy specimens made at laparoscopy confirmed the diagnosis. The report noted pelvic endometriosis associated but there was no umbilical or pleural involvement. The evolution was favorable under a long term hormone treatment (by GnRH analogues) with relay through continuous estrogen-progestogen. The diagnostic and therapeutic difficulties of this rare form of endometriosis are presented through a review of the literature.","PeriodicalId":23302,"journal":{"name":"Tropical Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47748374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pregnancy and prosthetic heart valves: A case series 妊娠与人工心脏瓣膜:病例系列
Pub Date : 2019-09-17 DOI: 10.4103/TJOG.TJOG_68_18
B. Barnali, S. Ranjan
Objectives: To assess the problems faced by pregnant women with prosthetic cardiac valves in terms of maternal and neonatal outcomes. Settings: Tertiary-level teaching hospital. Population: All pregnant women with prosthetic cardiac valves visiting the hospital in the period between January 2008 and September 2012. Method: Retrospective observational case series study. Results: Among the women presenting for antenatal visits to the hospital in the study period, eight were found to be have prosthetic cardiac valves. All cases had rheumatic origin of their cardiac lesion. Five cases had a mitral valve replacement. One had aortic and two had double-valve replacement. All patients had mechanical valves and were on anticoagulant regimen. Among them, one patient developed valve thrombosis and another developed embolic transient ischemic attack while in labor. Two patients developed symptomatic arrhythmia requiring treatment, while one patient had pneumonia with parapneumonic effusion. Three cases had abortions, while the other five pregnancies delivered live babies. All deliveries took place by lower segment Caesarean section (LSCS) for indications other than the cardiac condition. One pregnancy was complicated by intrauterine growth restriction and oligohydramnios. No patient developed any complications during the LSCS. There were no cases of warfarin embryopathy observed. Conclusion: Maternal complications tend to be higher in pregnant women with prosthetic cardiac valves requiring strict adherence to anticoagulant regimens and specialized treatment in tertiary care centers.
目的:评估植入人工心脏瓣膜的孕妇在产妇和新生儿预后方面所面临的问题。单位:三级教学医院。人群:所有在2008年1月至2012年9月期间就诊的装有心脏瓣膜的孕妇。方法:回顾性观察病例系列研究。结果:在研究期间到医院产前检查的妇女中,有8人被发现有人工心脏瓣膜。所有病例的心脏病变均为风湿病起源。5例二尖瓣置换术。一个做了主动脉瓣置换,两个做了双瓣置换。所有患者均有机械瓣膜并给予抗凝治疗。其中1例发生瓣膜血栓,1例在分娩时发生栓塞性短暂性脑缺血发作。2例患者出现需要治疗的症状性心律失常,1例患者出现肺炎伴肺旁积液。其中3例进行了流产,而另外5例则产下了活婴。除心脏疾病外,所有患者均采用下段剖宫产术(LSCS)分娩。1例妊娠并发宫内生长受限和羊水过少。在LSCS期间,没有患者出现任何并发症。未见华法林胚胎病病例。结论:在三级保健中心,需要严格遵守抗凝治疗方案和专门治疗的植入人工心脏瓣膜的孕妇,产妇并发症往往更高。
{"title":"Pregnancy and prosthetic heart valves: A case series","authors":"B. Barnali, S. Ranjan","doi":"10.4103/TJOG.TJOG_68_18","DOIUrl":"https://doi.org/10.4103/TJOG.TJOG_68_18","url":null,"abstract":"Objectives: To assess the problems faced by pregnant women with prosthetic cardiac valves in terms of maternal and neonatal outcomes. Settings: Tertiary-level teaching hospital. Population: All pregnant women with prosthetic cardiac valves visiting the hospital in the period between January 2008 and September 2012. Method: Retrospective observational case series study. Results: Among the women presenting for antenatal visits to the hospital in the study period, eight were found to be have prosthetic cardiac valves. All cases had rheumatic origin of their cardiac lesion. Five cases had a mitral valve replacement. One had aortic and two had double-valve replacement. All patients had mechanical valves and were on anticoagulant regimen. Among them, one patient developed valve thrombosis and another developed embolic transient ischemic attack while in labor. Two patients developed symptomatic arrhythmia requiring treatment, while one patient had pneumonia with parapneumonic effusion. Three cases had abortions, while the other five pregnancies delivered live babies. All deliveries took place by lower segment Caesarean section (LSCS) for indications other than the cardiac condition. One pregnancy was complicated by intrauterine growth restriction and oligohydramnios. No patient developed any complications during the LSCS. There were no cases of warfarin embryopathy observed. Conclusion: Maternal complications tend to be higher in pregnant women with prosthetic cardiac valves requiring strict adherence to anticoagulant regimens and specialized treatment in tertiary care centers.","PeriodicalId":23302,"journal":{"name":"Tropical Journal of Obstetrics and Gynaecology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46026718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Once treated, twice harmed: A case report of acquired gynatresia following vaginal insertion of herbs 一次治疗,二次伤害:阴道插入草药后获得性阴道痛1例报告
Pub Date : 2019-09-01 DOI: 10.4103/tjog.tjog_101_19
O. Allen, O. Badejoko
Gynatresia is the narrowing or complete occlusion of the vagina, which may be congenital or acquired. In Nigeria, acquired gynatresia is more common, usually resulting from the use of herbal pessaries. Its mere occurrence is indeed one social calamity to many. We present a case of a 37-year-old P0+1 with acquired gynatresia following insertion of herbal pessaries at a trado medical center. This was in an attempt to treat cryptomenorrhea which had developed following an abortion complicated by uterine perforation at a private hospital 20 years prior. Poor quality of medical care may push women to seek unsafe alternatives, resulting in even more harm.
回钠症是阴道狭窄或完全闭塞,可能是先天性的或后天性的。在尼日利亚,获得性妇科闭锁更为常见,通常是由使用草药子宫托引起的。它的发生对许多人来说确实是一场社会灾难。我们报告了一例37岁的P0+1患者,在传统医疗中心插入草药子宫托后出现获得性妇科闭锁。这是为了治疗20年前在一家私人医院流产并并发子宫穿孔后出现的月经隐痛。医疗服务质量差可能会促使妇女寻求不安全的替代方案,从而造成更大的伤害。
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引用次数: 0
Birth and sorrow: The medico-social consequences of obstetric fistula in Ilesha, Nigeria 出生和悲伤:尼日利亚伊莱沙产科瘘的医疗社会后果
Pub Date : 2019-09-01 DOI: 10.4103/TJOG.TJOG_32_19
AO Fehintola, F. Fehintola, AO Adetoye, EO Ayegbusi, OA Alaba, AD Ajiboye, O. Badejoko, BA Adeyemi
Background: Obstetric fistula is an abnormal communication between the epithelium of female genital tract and the bladder and (or) the rectum. It is not just “a hole”; it affects every aspect of the life of the sufferers. Objective: This study examined the etiology, psychosocial and medical consequences of obstetric fistula on the patients. Methodology: It was a cross-sectional study with quantitative and qualitative data collection methods employed. Quantitative data collection was done by the aid of a structured interviewer-administered questionnaire while qualitative data collection was by focus group discussions (FGDs) and in-depth interviews (IDIs). The sample consists of eligible and consenting patients with obstetric fistula admitted for repair at the Wesley Guild Hospital, Ilesha between July 2017 and August 2018. Purposive sampling technique was used to select 86 patients. Results: The mean age of patients was 28.7 years ± 7.5 (SD) with a divorce rate of 40%. Only 10% of them had their first marriage between ages 15 and 20 years. Prolong obstructed labor accounted for 55.8% of all the obstetric fistula in this study. The remaining were either following hysterectomy or cesarean section. Reported medical problems were dermatitis (60%), dyspareunia (25%), recurrent urinary tract infection (UTI) (10%), infertility (5%), and amenorrhea (5%). Socially, 45% felt ostracized, and 50% were economically impoverished by job loss. Some 56.6% respondents suggested that hospital delivery was a preventive measure, while 8% felt that avoidance of early marriage would prevent obstetric fistula. Conclusion: Obstetric fistula is still a major reproductive health problem. Most of these patients understand the role of unsupervised childbirth in its development.
背景:产科瘘是女性生殖道上皮与膀胱和(或)直肠之间的异常通信。它不仅仅是一个“洞”;它影响着患者生活的方方面面。目的:本研究探讨了产科瘘对患者的病因、心理社会和医疗后果。方法:采用横断面研究,采用定量和定性资料收集方法。定量数据收集是通过结构化的访谈者管理的问卷来完成的,而定性数据收集是通过焦点小组讨论(fgd)和深度访谈(IDIs)来完成的。样本包括2017年7月至2018年8月期间在Ilesha卫斯理公会医院接受修复的符合条件和同意的产科瘘患者。采用目的抽样方法,选取86例患者。结果:患者平均年龄28.7岁±7.5 (SD),离婚率为40%。其中只有10%的人在15岁到20岁之间有了第一次婚姻。延长难产占本研究所有产科瘘的55.8%。其余的要么是子宫切除术,要么是剖宫产。报告的医疗问题是皮炎(60%)、性交困难(25%)、复发性尿路感染(10%)、不孕症(5%)和闭经(5%)。在社会方面,45%的人感到被排斥,50%的人因失业而陷入经济贫困。约56.6%的答复者认为住院分娩是一种预防措施,而8%的答复者认为避免早婚将预防产科瘘管病。结论:产科瘘仍然是一个主要的生殖健康问题。大多数患者了解无人监护分娩在其发展中的作用。
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引用次数: 3
期刊
Tropical Journal of Obstetrics and Gynaecology
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