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Combined Effects of Prone Positioning and Airway Pressure Release Ventilation on Oxygenation in Patients with COVID-19 ARDS. 俯卧位加气道压力释放通气对COVID-19 ARDS患者氧合的影响。
IF 0.5 Q3 ANESTHESIOLOGY Pub Date : 2023-06-16 DOI: 10.4274/TJAR.2022.22783
Bişar Ergün, Mehmet Nuri Yakar, Murat Küçük, Narmin Baghiyeva, Ahmet Naci Emecen, Erdem Yaka, Begüm Ergan, Ali Necati Gökmen
Objective: Coronavirus disease 2019 (COVID-19) can cause acute respiratory distress syndrome (ARDS). Invasive mechanical ventilation (IMV) support and prone positioning are essential treatments for severe COVID-19 ARDS. We aimed to determine the combined effect of prone position and airway pressure release ventilation (APRV) modes on oxygen improvement in mechanically-ventilated patients with COVID-19. Methods: This prospective observational study included 40 eligible patients (13 female, 27 male). Of 40 patients, 23 (57.5%) were ventilated with APRV and 17 (42.5%) were ventilated with controlled modes. A prone position was applied when the PaO2/FiO2 ratio <150 mmHg despite IMV in COVID-19 ARDS. The numbers of patients who completed the first, second, and third prone were 40, 25, and 15, respectively. Incident barotrauma events were diagnosed by both clinical findings and radiological images. Results: After the second prone, the PaO2/FiO2 ratio of the APRV group was higher compared to the PaO2/FiO2 ratio of the control group [189 (150-237)] vs. 127 (100-146) mmHg, respectively, (P=0.025). Similarly, after the third prone, the PaO2/FiO2 ratio of the APRV group was higher compared to the PaO2/FiO2 ratio of the control group [194 (132-263)] vs. 83 (71-136) mmHg, respectively, (P=0.021). Barotrauma events were detected in 13.0% of the patients in the APRV group and 11.8% of the patients in the control group (P=1000). The 28-day mortality was not different in the APRV group than in the control group (73.9% vs. 70.6%, respectively, P=1000). Conclusion: Using the APRV mode during prone positioning improves oxygenation, especially in the second and third prone positions, without increasing the risk of barotrauma. However, no benefit on mortality was detected.
目的:冠状病毒病2019 (COVID-19)可引起急性呼吸窘迫综合征(ARDS)。有创机械通气(IMV)支持和俯卧位是重症COVID-19 ARDS的基本治疗方法。我们的目的是确定俯卧位和气道压力释放通气(APRV)模式对机械通气的COVID-19患者氧改善的联合影响。方法:本前瞻性观察研究纳入40例符合条件的患者(女性13例,男性27例)。40例患者中,APRV通气23例(57.5%),控制模式通气17例(42.5%)。结果:第二次俯卧后,APRV组PaO2/FiO2比值高于对照组[189(150-237)]和127 (100-146)mmHg,差异有统计学意义(P=0.025)。同样,第三次发作后,APRV组PaO2/FiO2比值高于对照组[194(132-263)]和83 (71-136)mmHg,差异有统计学意义(P=0.021)。APRV组13.0%的患者检测到气压创伤事件,对照组11.8%的患者检测到气压创伤事件(P=1000)。APRV组28天死亡率与对照组无显著差异(分别为73.9% vs. 70.6%, P=1000)。结论:俯卧位时使用APRV模式可改善氧合,特别是在第二和第三俯卧位时,不会增加气压损伤的风险。然而,没有发现对死亡率有任何好处。
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引用次数: 0
Effect of Educational Tools on the use of Patient-Controlled Analgesia Devices. 教育工具对患者自控镇痛装置使用的影响。
IF 0.5 Q3 ANESTHESIOLOGY Pub Date : 2023-06-16 DOI: 10.4274/TJAR.2022.22988
Olcayto Uysal, Serkan Karaman, Tuğba Karaman

Objective: In the literature, there are confusing data about educational tools and device use. Therefore, it is not clear which method is superior to the other. The aim of this study was to evaluate the effects of educational tools on patient-controlled analgesia (PCA) usage in patients undergoing hysterectomy.

Methods: Ninety-six patients undergoing hysterectomy were enrolled in the study. Patients were randomly assigned to a group (verbal, brochure, or video) consisting of 32 patients each using the closed envelope method. After operations, all patients were sent to the ward and evaluated with numerical rating scale score for pain at 15th min., 2nd, 4th, 6th, 12th, 18th, 2nd, 4th, 6th, 12th, 18th, 24th hours. Given dose, the number of button presses, presence of nausea and vomiting, and static and dynamic pain scores were recorded. During visits, patients who had a pain score ≥4 were administered paracetamol 1 g IV. Ondansetron 8 mg IV was injected into patients who had nausea and vomiting.

Results: No significant differences were determined in resting and dynamic pain scores, number of button presses, and given doses between groups at 15th min., 2nd, 4th, 6th, 12th, 18th, 24th hours.

Conclusion: In this study, education type did not affect PCA device use. We believe that whatever method the infrastructure of hospitals is suitable for, should be used for PCA device education.

目的:在文献中,关于教育工具和设备使用的数据令人困惑。因此,尚不清楚哪种方法优于另一种方法。本研究的目的是评估教育工具对子宫切除术患者自控镇痛(PCA)使用的影响。方法:96例子宫切除术患者纳入研究。患者被随机分配到一组(口头、宣传册或视频),每组32例患者使用封闭信封法。术后第15分钟、第2、第4、第6、第12、第18、第2、第4、第6、第12、第18、第24小时采用数值评定量表对患者进行疼痛评分。在给定的剂量下,记录按下按钮的次数,恶心和呕吐的出现,以及静态和动态疼痛评分。就诊时,疼痛评分≥4分的患者给予扑热息痛1 g IV。出现恶心呕吐的患者给予昂丹司琼8 mg IV。结果:各组在15 min、2、4、6、12、18、24 h静息、动态疼痛评分、按下按钮次数、给药剂量均无显著差异。结论:在本研究中,教育程度对PCA器械的使用没有影响。我们认为,无论医院的基础设施如何适合,都应该采用PCA设备教育。
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引用次数: 0
Positive Bubble Study But No Evidence of Interatrial Defect in a Patient with Recurrent Cryptogenic Stroke. 隐源性卒中复发患者的阳性气泡研究未发现心房缺损的证据。
IF 0.5 Q3 ANESTHESIOLOGY Pub Date : 2023-06-16 DOI: 10.4274/TJAR.2022.221106
Nika Samadzadeh Tabrizi, Perry A Stout, Joseph Cahill, Imran Ramzan Sunesara, Patrick Chan, Chanderdeep Singh, Thomas Fabian, Alexander D Shapeton, Sridhar Reddy Musuku

Pulmonary arteriovenous malformations (PAVMs) can be asymptomatic or result in a range of complications such as brain abscesses or cryptogenic emboli, which can contribute to morbidity and mortality if not diagnosed and treated in a timely manner. To date, there have been several reports of delayed diagnosis of PAVMs, which have been largely attributed to the misconception that PAVMs are too rare to be of clinical significance. Furthermore, because intracardiac shunting secondary to a patent foramen ovale (PFO) or atrial septal defect (ASD) also results in a positive saline contrast study with echocardiography, PAVM can be easily misdiagnosed as an intracardiac right-toleft shunt. However, there are unique echocardiographic features that differentiate between intracardiac shunting due to a PFO or ASD and extracardiac shunting such as in PAVM. This case details the course of a patient with recurrent cryptogenic strokes that was initially misattributed to a PFO and was only correctly diagnosed with multiple PAVMs after two failed attempts at PFO closure. This case serves as a reminder of an alternative etiology of right-to-left shunt and its presentation on imaging, which echocardiographers must be familiar with.

肺动静脉畸形(pavm)可能无症状或导致一系列并发症,如脑脓肿或隐源性栓塞,如果不及时诊断和治疗,可能导致发病率和死亡率。迄今为止,已经有几篇关于pavm延迟诊断的报道,这在很大程度上归因于pavm太罕见而不具有临床意义的误解。此外,由于继发于卵圆孔未闭(PFO)或房间隔缺损(ASD)的心内分流也会导致超声心动图生理盐水对比检查呈阳性,因此PAVM很容易被误诊为心内右至左分流。然而,有独特的超声心动图特征来区分由PFO或ASD引起的心内分流和心外分流(如PAVM)。本病例详细描述了一名复发性隐源性卒中患者的病程,该患者最初被误诊为PFO,在两次尝试关闭PFO失败后才被正确诊断为多发性pavm。这个病例提醒我们右至左分流的另一种病因及其影像学表现,超声心动图医师必须熟悉。
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引用次数: 0
Awareness of Postdural Puncture Headache Among Specialists who Perform Lumbar Punctures and/or Monitor Patients Following the Procedure. 实施腰椎穿刺和/或术后监测患者的专家对硬脊膜后穿刺头痛的认识。
IF 0.5 Q3 ANESTHESIOLOGY Pub Date : 2023-06-16 DOI: 10.4274/TJAR.2023.221128
Mesut Bakır, Şebnem Rumeli, Ümit Durmuşoğlu, Erman Balıkçı

Objective: Lumbar puncture (LP) is performed by specialists in different branches of medicine, complications may be encountered in various settings. In our study, we evaluated the awareness and knowledge of the diagnosis and treatment of post-dural puncture headache (PDPH) among specialists who performed LP and/or encountered complications.

Methods: This was a prospective questionnaire/scale study of 253 physicians: LP performers (anaesthesiologists, Group A; others, Group B) and those who worked in departments that did not perform LP but frequently encountered complications following LP (Group C). The questionnaire assessed specialization, frequency of LPs utilization, needle types used, positions employed, awareness of LP complications, diagnosis, management, and risk factors for PDPH.

Results: Group A had the highest percentage of physicians who stated they had knowledge about PDPH (Group A: 96.4%, Group B: 77.3%, Group C: 39.4%; P=0.000). Group C was found to be statistically less informed than the other two groups (P=0.000). It was determined that only one (1%) physician from Group C correctly answered the question about the diagnostic criteria for PDPH.

Conclusion: To our knowledge this is the first study in which the awareness of PDPH has been compared according to physicians' fields of specialisation. We believe that post-specialty training programs should be organized for physicians who will either perform LP or monitor patients who have undergone LP, and the curriculum content in relevant specialties should be reviewed.

目的:腰椎穿刺(LP)是由不同医学分支的专家进行的,在不同的情况下可能会遇到并发症。在我们的研究中,我们评估了实施LP和/或遇到并发症的专家对硬脊膜穿刺后头痛(PDPH)的诊断和治疗的认识和知识。方法:对253名医生进行前瞻性问卷/量表研究:LP表演者(麻醉师,a组;其他(B组)和那些在不做LP但经常遇到LP并发症的部门工作的人(C组)。问卷评估专业化,LP使用频率,使用的针头类型,使用的位置,对LP并发症的认识,诊断,管理和PDPH的危险因素。结果:A组医生表示对PDPH有了解的比例最高(A组:96.4%,B组:77.3%,C组:39.4%;P = 0.000)。在统计学上,C组的知情程度低于其他两组(P=0.000)。C组仅有1位(1%)医生正确回答了PDPH的诊断标准问题。结论:据我们所知,这是第一个根据医生的专业领域比较PDPH意识的研究。我们认为,对于执行LP或监测LP患者的医生,应组织专科后培训计划,并对相关专业的课程内容进行审查。
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引用次数: 0
Is Laryngeal Mask a Good Alternative in Children Undergoing Laparoscopic Inguinal Hernia Repair with Percutaneous Internal Ring Suturing Under and Over Two Years Old? 喉罩是2岁以下及2岁以上儿童经皮内环缝合腹腔镜腹股沟疝修补术的好选择吗?
IF 0.5 Q3 ANESTHESIOLOGY Pub Date : 2023-06-16 DOI: 10.4274/TJAR.2023.221176
Damla Uysal, Sanem Çakar Turhan, Ergun Ergün, Özlem Selvi Can

Objective: This study aimed to evaluate respiratory parameters during percutaneous internal ring suturing (PIRS) for inguinal hernia repair in two different-aged pediatric patients in whom the airway is provided with a laryngeal mask or endotracheal tube for general anaesthesia.

Methods: After local ethics committee and parental consent, 180 ASAI-II children were randomly allocated to 4 groups; according to their age (0-24 months / 25-144 months) and airway device laryngeal mask (LMA) / endotracheal tube (ETT) used for general anaesthesia (45 children each) for laparoscopic inguinal hernia repair. Standard anaesthesia induction was done with lidocaine, propofol, and fentanyl, and 0.6 mg kg-1 rocuronium was added to the ETT groups. Sevoflurane is used for maintenance. Hemodynamic parameters, peak airway pressure, end-tidal carbon dioxide (EtCO2), and peripheric oxygen saturation (SpO2) values were recorded after induction, before, and during pneumoperitoneum. The duration of anaesthesia, surgery, recovery time, and surgical satisfaction was recorded. Airway complications (cough, laryngospasm, bronchospasm, desaturation, and aspiration) were recorded.

Results: Hundred and eighty patients (45 in each group) were analyzed. Duration of surgery and surgical satisfaction were similar in all groups. Duration of anaesthesia and recovery times were significantly shorter in the LMA groups. Peak airway pressure and EtCO2 levels were significantly lower in the LMA groups. Rare airway complications were observed without significance.

Conclusion: In laparoscopic inguinal hernia repair with the PIRS technique, LMA offered comparable operating conditions and surgical satisfaction.

目的:本研究旨在评估两名不同年龄的儿童患者在经皮内环缝合(PIRS)进行腹股沟疝修补术时的呼吸参数,这些患者的气道分别是喉罩或气管内管进行全身麻醉。方法:经当地伦理委员会审核并征得家长同意后,将180例ASAI-II患儿随机分为4组;根据患儿年龄(0-24个月/ 25-144个月)采用气道装置喉罩(LMA) /气管内管(ETT)全麻(各45例)行腹腔镜腹股沟疝修补术。标准麻醉诱导采用利多卡因、异丙酚和芬太尼,ETT组加入0.6 mg kg-1罗库溴铵。七氟烷用于维护。记录诱导后、气腹前和气腹期间的血流动力学参数、气道峰值压力、潮末二氧化碳(EtCO2)和外周氧饱和度(SpO2)值。记录麻醉时间、手术时间、恢复时间和手术满意度。记录气道并发症(咳嗽、喉痉挛、支气管痉挛、去饱和和误吸)。结果:共分析180例患者,每组45例。两组患者的手术时间和手术满意度相似。LMA组麻醉时间和恢复时间明显缩短。LMA组气道压力峰值和EtCO2水平明显降低。气道并发症发生率低,无统计学意义。结论:PIRS技术在腹腔镜腹股沟疝修补术中,LMA具有相当的手术条件和手术满意度。
{"title":"Is Laryngeal Mask a Good Alternative in Children Undergoing Laparoscopic Inguinal Hernia Repair with Percutaneous Internal Ring Suturing Under and Over Two Years Old?","authors":"Damla Uysal,&nbsp;Sanem Çakar Turhan,&nbsp;Ergun Ergün,&nbsp;Özlem Selvi Can","doi":"10.4274/TJAR.2023.221176","DOIUrl":"https://doi.org/10.4274/TJAR.2023.221176","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate respiratory parameters during percutaneous internal ring suturing (PIRS) for inguinal hernia repair in two different-aged pediatric patients in whom the airway is provided with a laryngeal mask or endotracheal tube for general anaesthesia.</p><p><strong>Methods: </strong>After local ethics committee and parental consent, 180 ASAI-II children were randomly allocated to 4 groups; according to their age (0-24 months / 25-144 months) and airway device laryngeal mask (LMA) / endotracheal tube (ETT) used for general anaesthesia (45 children each) for laparoscopic inguinal hernia repair. Standard anaesthesia induction was done with lidocaine, propofol, and fentanyl, and 0.6 mg kg<sup>-1</sup> rocuronium was added to the ETT groups. Sevoflurane is used for maintenance. Hemodynamic parameters, peak airway pressure, end-tidal carbon dioxide (EtCO<sub>2</sub>), and peripheric oxygen saturation (SpO<sub>2</sub>) values were recorded after induction, before, and during pneumoperitoneum. The duration of anaesthesia, surgery, recovery time, and surgical satisfaction was recorded. Airway complications (cough, laryngospasm, bronchospasm, desaturation, and aspiration) were recorded.</p><p><strong>Results: </strong>Hundred and eighty patients (45 in each group) were analyzed. Duration of surgery and surgical satisfaction were similar in all groups. Duration of anaesthesia and recovery times were significantly shorter in the LMA groups. Peak airway pressure and EtCO2 levels were significantly lower in the LMA groups. Rare airway complications were observed without significance.</p><p><strong>Conclusion: </strong>In laparoscopic inguinal hernia repair with the PIRS technique, LMA offered comparable operating conditions and surgical satisfaction.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"51 3","pages":"255-263"},"PeriodicalIF":0.5,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9886235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pre-anaesthesia Telephone Consultation: A Safe Alternative for Anaesthesia Assessment in Case of Repeated Low or Intermediate Risk Surgeries: A Prospective Cohort Study. 麻醉前电话咨询:一项前瞻性队列研究:在重复低或中风险手术的情况下,麻醉评估的安全选择。
IF 0.5 Q3 ANESTHESIOLOGY Pub Date : 2023-06-16 DOI: 10.4274/TJAR.2022.221079
Charles-Herve Vacheron, Clemence Ferrier, Estelle Morau, Alexandre Theissen, Vincent Piriou, Pierre Yves Carry, Arnaud Friggeri

Objective: Telemedicine has widely expanded during the coronavirus disease-2019 pandemic. Our objective was to evaluate the feasibility, safety, effectiveness, and satisfaction of pre-anaesthesia telephone consultation (PATC).

Methods: From December 2015 to October 2016, a prospective survey was administered to anaesthesiologists, nurse anaesthetists, and patients of the ambulatory and maxillofacial departments. Patients having a pre-anaesthesia consultation (PAC) within the previous year in the department, whose health state was considered stable, and for whom the surgical procedure was related to the previous one, were eligible for PATC. Three questionnaires concerning the pre- (Q1), per- (Q2), and postoperative (Q3) periods were answered by the patient, the anaesthesiologist, and the anaesthesiologist nurse to evaluate the feasibility and satisfaction of the PATC. We collected the cancelation rate and any incident occurring during the surgery.

Results: Over the study period, 210 patients were included. The response rate was 200/210 (95.2%) for Q1, 108/208 (51.9%) for Q2 and 146/208 (70.2%) for Q3. PATC was performed in a median (IQR) of 13 (7-20) days before the procedure. Patients answered directly in 73% of cases without the need for recall. During surgery, 4 incidents occurred and none were attributable to PATC. Patient satisfaction was 93.3% and 85.8% of them preferred PATC to conventional PAC. The kilometric saving was 74 (30-196) km per PATC.

Conclusion: Both patients and professionals were satisfied with PATC, which did not impact safety. On the selected patients, PATC brings many practical benefits and increases organizational flexibility.

目的:2019冠状病毒病大流行期间,远程医疗得到了广泛推广。我们的目的是评估麻醉前电话咨询(PATC)的可行性、安全性、有效性和满意度。方法:2015年12月至2016年10月,对门诊及颌面科麻醉医师、麻醉护士及患者进行前瞻性调查。前一年在该科进行过麻醉前会诊(PAC)的患者,其健康状况被认为是稳定的,并且手术过程与前一次手术有关,有资格进行麻醉前会诊。由患者、麻醉师和麻醉师护士分别回答术前(Q1)、术后(Q2)和术后(Q3)三份问卷,以评估PATC的可行性和满意度。我们收集了手术取消率和手术过程中发生的任何事件。结果:在研究期间,纳入了210例患者。第一季度的回复率为200/210(95.2%),第二季度为108/208(51.9%),第三季度为146/208(70.2%)。PATC在手术前的中位(IQR)为13(7-20)天。73%的病人直接回答,不需要回忆。术中发生4起事件,无一例可归因于PATC。患者满意度为93.3%,85.8%的患者选择PATC而不是传统的PAC。每个PATC可节省74(30-196)公里。结论:患者和专业人员均对PATC满意,不影响安全性。对于选定的患者,PATC带来了许多实际的好处,并增加了组织的灵活性。
{"title":"Pre-anaesthesia Telephone Consultation: A Safe Alternative for Anaesthesia Assessment in Case of Repeated Low or Intermediate Risk Surgeries: A Prospective Cohort Study.","authors":"Charles-Herve Vacheron,&nbsp;Clemence Ferrier,&nbsp;Estelle Morau,&nbsp;Alexandre Theissen,&nbsp;Vincent Piriou,&nbsp;Pierre Yves Carry,&nbsp;Arnaud Friggeri","doi":"10.4274/TJAR.2022.221079","DOIUrl":"https://doi.org/10.4274/TJAR.2022.221079","url":null,"abstract":"<p><strong>Objective: </strong>Telemedicine has widely expanded during the coronavirus disease-2019 pandemic. Our objective was to evaluate the feasibility, safety, effectiveness, and satisfaction of pre-anaesthesia telephone consultation (PATC).</p><p><strong>Methods: </strong>From December 2015 to October 2016, a prospective survey was administered to anaesthesiologists, nurse anaesthetists, and patients of the ambulatory and maxillofacial departments. Patients having a pre-anaesthesia consultation (PAC) within the previous year in the department, whose health state was considered stable, and for whom the surgical procedure was related to the previous one, were eligible for PATC. Three questionnaires concerning the pre- (Q1), per- (Q2), and postoperative (Q3) periods were answered by the patient, the anaesthesiologist, and the anaesthesiologist nurse to evaluate the feasibility and satisfaction of the PATC. We collected the cancelation rate and any incident occurring during the surgery.</p><p><strong>Results: </strong>Over the study period, 210 patients were included. The response rate was 200/210 (95.2%) for Q1, 108/208 (51.9%) for Q2 and 146/208 (70.2%) for Q3. PATC was performed in a median (IQR) of 13 (7-20) days before the procedure. Patients answered directly in 73% of cases without the need for recall. During surgery, 4 incidents occurred and none were attributable to PATC. Patient satisfaction was 93.3% and 85.8% of them preferred PATC to conventional PAC. The kilometric saving was 74 (30-196) km per PATC.</p><p><strong>Conclusion: </strong>Both patients and professionals were satisfied with PATC, which did not impact safety. On the selected patients, PATC brings many practical benefits and increases organizational flexibility.</p>","PeriodicalId":23353,"journal":{"name":"Turkish journal of anaesthesiology and reanimation","volume":"51 3","pages":"207-212"},"PeriodicalIF":0.5,"publicationDate":"2023-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10339756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10189511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paracetamol Versus Ondansetron for Prevention of Postoperative Shivering in Liposuction Surgeries Under Combined General Epidural Anaesthesia: A Randomized Controlled Trial. 扑热息痛与昂丹司琼联合硬膜外麻醉预防吸脂术后寒战:一项随机对照试验
IF 0.5 Q3 ANESTHESIOLOGY Pub Date : 2023-06-16 DOI: 10.4274/TJAR.2022.22927
Amr Samir Wahdan, George Eshak Loza, Hussain Othman Alshehri, Ahmed Farag Shedid, Atef Kamel Salama, Wessam Samir Wahdan, Mennatallah Magdi Mohamed

Objective: Postoperative shivering (POS) is considered one of the most common complications that is encountered by the anaesthetists worldwide. Despite using several treatment options, there has not been a clear consensus regarding this issue. This trial was conducted to investigate the efficacy and safety of paracetamol and ondansetron in preventing POS in patients undergoing liposuction procedures under combined general epidural anaesthesia.

Methods: One hundred twenty patients scheduled for liposuction were randomly allocated to one of three groups: group P (paracetamol group) which received 1 g paracetamol intravenously, group O (ondansetron group) which received 8 mg of ondansetron intravenously, and group S (saline group), which received 100 mL normal saline intravenously; all medications were given postoperatively. The primary outcome was the incidence of POS, and the secondary outcomes included shivering score, tympanic temperature, and the occurrence of side effects.

Results: The incidence of occurrence of POS was found to be lower in groups P and O compared to group S with values of 25% and 37.50% vs. 77.50%, respectively, with a P value <0.001. Additionally, the severity of POS was found to be lower in groups P and O compared to group S (P <0.001). Tympanic temperature and complications were comparable between the groups with no significant differences.

Conclusion: Prophylactic use of paracetamol or ondansetron at the end of the procedure was shown to be of great value in reducing the incidence and severity of POS, with no statistically significant difference between the paracetamol and ondansetron groups. Moreover, no significant drawbacks were reported as a result of using these medications.

目的:术后寒战(POS)被认为是全世界麻醉师最常见的并发症之一。尽管使用了几种治疗方案,但在这个问题上还没有明确的共识。本试验旨在探讨扑热息痛和昂丹司琼预防硬膜外联合全身麻醉吸脂术患者发生POS的有效性和安全性。方法:120例抽脂患者随机分为3组:P组(扑热息痛组)静脉滴注扑热息痛1 g, O组(昂丹司琼组)静脉滴注昂丹司琼8 mg, S组(生理盐水组)静脉滴注生理盐水100 mL;所有药物均在术后给予。主要结局是POS的发生率,次要结局包括寒战评分、鼓室温度和副作用的发生。结果:P组和O组的POS发生率较S组低,分别为25%和37.50%比77.50%,P值为P。结论:在手术结束时预防性使用扑热息痛或昂丹司琼对降低POS的发生率和严重程度具有重要价值,扑热息痛组和昂丹司琼组之间差异无统计学意义。此外,使用这些药物没有明显的缺陷。
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引用次数: 0
The Efficacy of Erector Spinae Plane Block for Patients Undergoing Percutaneous Nephrolithotomy. 竖脊平面阻滞在经皮肾镜取石术中的疗效观察。
IF 0.5 Q3 ANESTHESIOLOGY Pub Date : 2023-06-16 DOI: 10.4274/TJAR.2022.22981
Mehmet Uğur Bilgin, Zeki Tuncel Tekgül, Tansu Değirmenci

Objective: Percutaneous nephrolithotomy (PCNL) is accompanied by somatic and visceral pain intraoperatively and postoperatively. However, pain management strategies lack a decisive consensus. Erector spinae plane block (ESPB) is a novel paraspinal fascial block that can be used in PCNL patients, and we aimed to investigate whether ESPB will reduce intraoperative and postoperative opioid consumption and postoperative pain scores in PCNL patients.

Methods: The study was randomized, controlled, and open-label. Two groups were formed as the control group (GCont) and block group (Gblock), and patients received total intravenous anaesthesia. GBlock received an ESPB catheter in addition in the prone position. Intraoperative parameters and infusion doses, postoperative rescue analgesic doses, and pain scores were recorded. The primary endpoint was intraoperative analgesic consumption, and the secondary endpoints were postoperative pain scores and analgesic consumption.

Results: Sixty-four patients were analyzed. Remifentanil consumption of GCont was found to be significantly higher (GBlock: 0.0865 ± 0.030 vs GCont: 0.1398 ± 0.034, μg kg-1 min-1, P < 0.001). The control group reported higher pain scores between the 30th min and 24th hours and needed more analgesics between the 1st and 6th hours postoperatively. GBlock received local anaesthetics via ESPB catheter before nephrostomy tube removal and fewer patients needed analgesics [5 patients (15.6%) vs. 28 patients (87.5%), P < 0.001]. GCont consumed more tramadol postoperatively (262.5 mg vs. 75 mg, P < 0.001).

Conclusion: We found that ESPB reduced intraoperative opioid consumption. It also reduced the need for rescue analgesia and postoperative pain scores during nephrostomy tube removal. We concluded that the ESPB catheter may effectively be used in analgesia management during and after PCNL operations.

目的:经皮肾镜取石术(PCNL)术中及术后伴有躯体及内脏疼痛。然而,疼痛管理策略缺乏决定性的共识。直立脊柱平面阻滞(Erector spinae plane block, ESPB)是一种可用于PCNL患者的新型椎旁筋膜阻滞,我们旨在探讨ESPB是否会减少PCNL患者术中和术后阿片类药物的消耗和术后疼痛评分。方法:随机、对照、开放标签研究。分为对照组(GCont)和阻滞组(Gblock)两组,均给予全静脉麻醉。GBlock在俯卧位上另外放置了ESPB导管。记录术中参数及输注剂量、术后抢救镇痛剂量、疼痛评分。主要终点是术中镇痛消耗,次要终点是术后疼痛评分和镇痛消耗。结果:共分析64例患者。GCont的瑞芬太尼消耗量显著高于GCont (GBlock: 0.0865±0.030 vs GCont: 0.1398±0.034,μ kg-1 min-1, P < 0.001)。对照组患者术后30 ~ 24小时疼痛评分较高,术后1 ~ 6小时需要较多镇痛药。GBlock在取肾造口管前通过ESPB导管局部麻醉,需要镇痛的患者较少[5例(15.6%)比28例(87.5%),P < 0.001]。GCont术后消耗更多曲马多(262.5 mg vs 75 mg, P < 0.001)。结论:我们发现ESPB减少了术中阿片类药物的消耗。它还减少了肾造口管拔除过程中抢救镇痛和术后疼痛评分的需要。我们的结论是ESPB导管可以有效地用于PCNL手术期间和之后的镇痛管理。
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引用次数: 1
Challenging Anaesthesia Management of a Patient with Fryns Syndrome: A Case Report. Fryns综合征患者具有挑战性的麻醉管理:1例报告。
IF 0.5 Q3 ANESTHESIOLOGY Pub Date : 2023-06-16 DOI: 10.4274/TJAR.2022.221038
Celal Kaya, Pınar Kendigelen, Kadir Melih Yılmaz, Ayşe Çiğdem Tütüncü, Güner Kaya

Fryns syndrome cases with variable characteristics require careful preoperative evaluation and have challenges for airway management. Craniofacial anomalies can complicate both ventilation and intubation. Extubation can also be problematic because of limited pulmonary reserves.

具有不同特征的Fryns综合征病例需要仔细的术前评估,并对气道管理提出挑战。颅面异常可使通气和插管复杂化。由于肺储备有限,拔管也有问题。
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引用次数: 0
The Relationship Between Decreased CD-8 T-Cells and Mortality in Patients with COVID-19 Pneumonia in the Intensive Care Unit, A Retrospective Study. 重症监护病房COVID-19肺炎患者CD-8 t细胞下降与死亡率关系的回顾性研究
IF 0.5 Q3 ANESTHESIOLOGY Pub Date : 2023-06-16 DOI: 10.4274/TJAR.2022.22959
Zeynep Tuğçe Sarıkaya, Bülent Güçyetmez, Ayşe Sesin Kocagöz, Lütfi Telci, İbrahim Özkan Akıncı

Objective: CD-8 T-cells are responsible for the clearance of virally infected cells. In patients with Coronavirus disease-2019 (COVID-19) pneumonia, there are quantitative reductions and functional impairments in T-cells. Low CD-8 T-cell levels cause worse clinical situations. In this study, the relationship between decreased CD-8 T-cells and mortality in patients with COVID-19 pneumonia in the intensive care unit (ICU) was investigated.

Methods: In this multicenter retrospective study, 277 patients were analyzed. Demographic data, ICU admission scores, blood gas levels, laboratory samples, and outcomes were recorded. Statistical Package for the Social Sciences version 28 was used for statistical analysis.

Results: Two hundred forty of 277 patients were included in the study. The mortality rate was 43.3%. In non-survivors, median values of age, Charlson comorbidity index, Acute Physiology and Chronic Health Evaluation II (APACHE-II), procalcitonin, leukocyte count, neutrophil count, neutrophil-lymphocyte count ratio, and duration of invasive mechanical ventilation were significantly higher, whereas median values of PaO2-FiO2 ratio, lymphocyte count, CD-4, and CD-8 T-cells were significantly lower than those in survivors. In the multivariate Cox regression model, the risk of mortality increased 1.04-fold (1.02-1.06) and 1.05-fold (1.01-10.8) by every one unit increase in age and APACHE-II, respectively, whereas it decreased 0.71-fold (0.58-0.87) by every hundred increase in CD-8 T-cells P < 0.001, P=0.007 and P=0.001 respectively.

Conclusion: According to our findings, age, APACHE-II, and CD-8 T-cell levels seem to be independent risk factors for mortality in patients with COVID-19 pneumonia in the ICU.

目的:CD-8 t细胞负责清除病毒感染细胞。在冠状病毒病-2019 (COVID-19)肺炎患者中,t细胞数量减少和功能受损。低CD-8 t细胞水平会导致更糟糕的临床情况。本研究探讨重症监护病房(ICU) COVID-19肺炎患者CD-8 t细胞下降与死亡率的关系。方法:对277例患者进行多中心回顾性研究。记录人口统计数据、ICU入院评分、血气水平、实验室样本和结果。统计分析使用了社会科学统计软件包第28版。结果:277例患者中有240例纳入研究。死亡率为43.3%。在非幸存者中,年龄、Charlson合病指数、急性生理和慢性健康评估II (Acute Physiology and Chronic Health Evaluation II, APACHE-II)、降钙素原、白细胞计数、中性粒细胞计数、中性粒细胞-淋巴细胞计数比和有创机械通气时间的中位数显著高于幸存者,而PaO2-FiO2比、淋巴细胞计数、CD-4和CD-8 t细胞的中位数显著低于幸存者。在多因素Cox回归模型中,年龄和APACHE-II每增加1个单位,死亡风险分别增加1.04倍(1.02-1.06)和1.05倍(1.01-10.8),而CD-8 t细胞每增加100个单位,死亡风险分别降低0.71倍(0.58-0.87),P < 0.001, P=0.007和P=0.001。结论:根据我们的研究结果,年龄、APACHE-II和CD-8 t细胞水平似乎是ICU COVID-19肺炎患者死亡的独立危险因素。
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Turkish journal of anaesthesiology and reanimation
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