Pub Date : 2020-01-01DOI: 10.15406/jdc.2020.04.00162
A. Wall
Cutaneous ageing is realised through two distinct processes, namely intrinsic and extrinsic ageing. Intrinsic ageing, which is regarded as an inexorable fate, is largely dictated, and ultimately predetermined, by genetics.1–3 Extrinsic ageing, however, is induced by environmental factors such as exposure to ultraviolet radiation (UVR), nicotine and air pollutants, and is therefore considered to be under a certain degree of voluntary control.4 The effects of intrinsic and extrinsic ageing have discrete manifestations; with chronological skin ageing typified by atrophy and finer wrinkles, and extrinsic ageing characterised by epidermal thickening, discoloration and deeper wrinkles.5 In spite of this, interestingly, the molecular pathways of intrinsic and extrinsic ageing largely converge,6–8 with the effects of UV induced photo ageing regarded as a superimposition on to those of intrinsic ageing.2,6,7,9
{"title":"pep_35E7UW, a natural peptide with cutaneous anti-ageing effects discovered within the Oryza sativa proteome through machine learning","authors":"A. Wall","doi":"10.15406/jdc.2020.04.00162","DOIUrl":"https://doi.org/10.15406/jdc.2020.04.00162","url":null,"abstract":"Cutaneous ageing is realised through two distinct processes, namely intrinsic and extrinsic ageing. Intrinsic ageing, which is regarded as an inexorable fate, is largely dictated, and ultimately predetermined, by genetics.1–3 Extrinsic ageing, however, is induced by environmental factors such as exposure to ultraviolet radiation (UVR), nicotine and air pollutants, and is therefore considered to be under a certain degree of voluntary control.4 The effects of intrinsic and extrinsic ageing have discrete manifestations; with chronological skin ageing typified by atrophy and finer wrinkles, and extrinsic ageing characterised by epidermal thickening, discoloration and deeper wrinkles.5 In spite of this, interestingly, the molecular pathways of intrinsic and extrinsic ageing largely converge,6–8 with the effects of UV induced photo ageing regarded as a superimposition on to those of intrinsic ageing.2,6,7,9","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91241676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.15406/jdc.2020.04.00154
K. Achehboune
We realised a retrospective analyse of the clinical and dermoscopic images and we raised the complications of all cases of Orf Nodule in our department of dermatology and venereology of Hassan II University Hospital of Fez in Morocco, over a period of one year, between January 2017 et January 2018. Our department is one of the largest teaching units in Morocco, integrated into a tertiary school; it is a reference hospital in the central region of the country.
{"title":"Orf’s nodules in Muslim communities after the religious sacrifice of goat and sheep, 7 cases","authors":"K. Achehboune","doi":"10.15406/jdc.2020.04.00154","DOIUrl":"https://doi.org/10.15406/jdc.2020.04.00154","url":null,"abstract":"We realised a retrospective analyse of the clinical and dermoscopic images and we raised the complications of all cases of Orf Nodule in our department of dermatology and venereology of Hassan II University Hospital of Fez in Morocco, over a period of one year, between January 2017 et January 2018. Our department is one of the largest teaching units in Morocco, integrated into a tertiary school; it is a reference hospital in the central region of the country.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88535280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.15406/JDC.2020.04.00143
B. Rocha
Introduction: Hemangiosarcoma is a rare vascular malignant neoplasm. Diagnosis is based on both clinical and histopathological features. Case Presentation: An 85-years-old white man presented with a 1-year history of progressive lesions on face and scalp. Physical examination revealed violaceous infiltrative plaques, with ulceration and bleeding, on the face and scalp, associated to numerous violaceous satellites papules. Histopathological examination revealed a neoplastic proliferation represented by slit-like anastomosing vascular channels that dissociated collagen fibers in the dermis, lined by atypical endothelium with moderately hyperchromatic and pleomorphic nuclei. Diagnostic conclusion was cutaneous angiosarcoma. Conclusions: Cutaneous angiosarcoma most often affects males (2:1), mostly Caucasian patients over 70 years old. It may originate from blood or lymphatic vessels. The most common form affects the face and scalp. There are varying degrees of cellular atypia, anastomosing slit-like channels, dissociation of collagen fibers, occasional hyaline globules and areas of hemorrhage. Immunohistochemistry confirmed blood vascular origin with diffuse positivity for CD34 and focally diffuse for factor VIII. We emphasize the need of clinicopathological correlation for early recognition and treatment.
{"title":"Back-to-basics of hemangiosarcoma of face and scalp: a case report","authors":"B. Rocha","doi":"10.15406/JDC.2020.04.00143","DOIUrl":"https://doi.org/10.15406/JDC.2020.04.00143","url":null,"abstract":"Introduction: Hemangiosarcoma is a rare vascular malignant neoplasm. Diagnosis is based on both clinical and histopathological features. Case Presentation: An 85-years-old white man presented with a 1-year history of progressive lesions on face and scalp. Physical examination revealed violaceous infiltrative plaques, with ulceration and bleeding, on the face and scalp, associated to numerous violaceous satellites papules. Histopathological examination revealed a neoplastic proliferation represented by slit-like anastomosing vascular channels that dissociated collagen fibers in the dermis, lined by atypical endothelium with moderately hyperchromatic and pleomorphic nuclei. Diagnostic conclusion was cutaneous angiosarcoma. Conclusions: Cutaneous angiosarcoma most often affects males (2:1), mostly Caucasian patients over 70 years old. It may originate from blood or lymphatic vessels. The most common form affects the face and scalp. There are varying degrees of cellular atypia, anastomosing slit-like channels, dissociation of collagen fibers, occasional hyaline globules and areas of hemorrhage. Immunohistochemistry confirmed blood vascular origin with diffuse positivity for CD34 and focally diffuse for factor VIII. We emphasize the need of clinicopathological correlation for early recognition and treatment.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86238638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.15406/JDC.2020.04.00169
F. Simoneti
Psoriasis consists of a chronic inflammatory disease with systemic character and may be associated with several comorbidities. Although its etiopathogenesis has not yet been fully elucidated, it is known that it is an immune-mediated pathology, especially by T cells. Like other inflammatory and autoimmune disorders, psoriasis is also related to changes in the cutaneous microbiome. Vitamin D deficiency is one of the conditions associated with pathologies whose microbiome is altered, although the causal relationship between these events is not precisely determined. Thus, the objective of this study was to estimate the prevalence of vitamin D deficiency in patients with psoriasis who attended the Dermatology Clinic of ABC Medical School (FMABC) and compare it to the prevalence of vitamin D deficiency among patients with non-inflammatory pathologies. 88 patients with psoriasis and 91 patients with non-inflammatory diseases (Control Group) were evaluated and had their serum vitamin D measured. It was observed that the Psoriasis Group had lower serum vitamin D levels compared to the Control Group (p<0.001) and It was observed that the chance of a person with psoriasis present low vitamin D levels is about seven times higher.
{"title":"The impact of vitamin D deficiency and microbiome in psoriasis versus non immune-mediated diseases","authors":"F. Simoneti","doi":"10.15406/JDC.2020.04.00169","DOIUrl":"https://doi.org/10.15406/JDC.2020.04.00169","url":null,"abstract":"Psoriasis consists of a chronic inflammatory disease with systemic character and may be associated with several comorbidities. Although its etiopathogenesis has not yet been fully elucidated, it is known that it is an immune-mediated pathology, especially by T cells. Like other inflammatory and autoimmune disorders, psoriasis is also related to changes in the cutaneous microbiome. Vitamin D deficiency is one of the conditions associated with pathologies whose microbiome is altered, although the causal relationship between these events is not precisely determined. Thus, the objective of this study was to estimate the prevalence of vitamin D deficiency in patients with psoriasis who attended the Dermatology Clinic of ABC Medical School (FMABC) and compare it to the prevalence of vitamin D deficiency among patients with non-inflammatory pathologies. 88 patients with psoriasis and 91 patients with non-inflammatory diseases (Control Group) were evaluated and had their serum vitamin D measured. It was observed that the Psoriasis Group had lower serum vitamin D levels compared to the Control Group (p<0.001) and It was observed that the chance of a person with psoriasis present low vitamin D levels is about seven times higher.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78802809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.15406/JDC.2020.04.00171
M. Hamad
Background: Evaluation of any curriculum in medical education helps the process of health profession education by providing valuable feedback to the programs in which the graduates train. Methods: This was a descriptive cross-sectional study conducted by observing and systematically documenting the ongoing performance of trainees in real clinical settings over a 6 months’ period from July 2017 to January 2018. The aim of this study was to evaluate the dermatology curriculum of Sudan Medical Specialization Board (SMSB) and to gather data that will help in identifying areas in need of improvement or change. The data was collected through structured questionnaires from three groups: 1) trainees, 2) patients and 3) trainers. Results: The study included 128 trainees, 178 patients and 22 trainers. The patient’s satisfaction rate with the medical care provided by dermatology doctors was high since 61.8% stated that they had an excellent care. The overall trainee’s satisfaction of the provided program was reported in 89.2%.The majority of trainers believe that the current curriculum is not updated and is not well implemented in the training. Trainers clearly stated that the number of trainees per batch participated in the program and the number of training centres are inadequate. They also raised their concerns that the current training program didn’t meet the desired outcomes. Conclusions: This study provides a general picture of dermatology postgraduate training in Sudan from different perspectives. In our evaluation of the SMSB dermatology curriculum, we found a well-developed program, with a good curriculum but poor implementation, leading to an unsatisfactory outcome.
{"title":"Evaluation of dermatology curriculum of Sudan medical specialization board: 2017-2018","authors":"M. Hamad","doi":"10.15406/JDC.2020.04.00171","DOIUrl":"https://doi.org/10.15406/JDC.2020.04.00171","url":null,"abstract":"Background: Evaluation of any curriculum in medical education helps the process of health profession education by providing valuable feedback to the programs in which the graduates train. Methods: This was a descriptive cross-sectional study conducted by observing and systematically documenting the ongoing performance of trainees in real clinical settings over a 6 months’ period from July 2017 to January 2018. The aim of this study was to evaluate the dermatology curriculum of Sudan Medical Specialization Board (SMSB) and to gather data that will help in identifying areas in need of improvement or change. The data was collected through structured questionnaires from three groups: 1) trainees, 2) patients and 3) trainers. Results: The study included 128 trainees, 178 patients and 22 trainers. The patient’s satisfaction rate with the medical care provided by dermatology doctors was high since 61.8% stated that they had an excellent care. The overall trainee’s satisfaction of the provided program was reported in 89.2%.The majority of trainers believe that the current curriculum is not updated and is not well implemented in the training. Trainers clearly stated that the number of trainees per batch participated in the program and the number of training centres are inadequate. They also raised their concerns that the current training program didn’t meet the desired outcomes. Conclusions: This study provides a general picture of dermatology postgraduate training in Sudan from different perspectives. In our evaluation of the SMSB dermatology curriculum, we found a well-developed program, with a good curriculum but poor implementation, leading to an unsatisfactory outcome.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73612276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.15406/jdc.2020.04.00151
F. Silver
Vibrational optical coherence tomography (VOCT) is a new non-invasive and non- destructive technique that can be used to image and measure the mechanical properties of skin. The technique uses infrared light and audible sound to image and measure the resonant frequency of tissue components. The stiffness (modulus) of each major tissue component is obtained from a calibration equation using values of the measured resonant frequency and tissue thickness. VOCT is used in this study to quantitatively compare the outcomes of cell proliferation and fibrous collagen deposition as a result of (1) a skin topical treatment (CE Ferulic) and (2) micro-needle roller application to human forehead skin. Both methods appear to quantitatively increase the ratio of cells to dermal collagen and the ratio of fibrotic collagen to dermal collagen with increasing time. Both chemical and mechanical treatments lead to cell proliferation and new collagen deposition using these skin rejuvenation procedures. While results obtained with micro-needle rolling are achieved more rapidly, collagen deposition with the topical is achieved painlessly. The new collagen that is deposited, using both methods, appears similar to that seen in wound healing and has a higher resonant frequency and modulus compared to normal dermal collagen. The results of this study suggest that VOCT can provide useful quantitative data to evaluate the efficacy of skin rejuvenation procedures. It is suggested that there is a need to develop techniques to regenerate normal dermal collagen as opposed to fibrotic collagen to reduce the stiffness of the new tissue formed.
{"title":"Virtual biopsies and vibrational-mechanical analysis of skin rejuvenation: comparison of results obtained with micro-needling and topical treatments","authors":"F. Silver","doi":"10.15406/jdc.2020.04.00151","DOIUrl":"https://doi.org/10.15406/jdc.2020.04.00151","url":null,"abstract":"Vibrational optical coherence tomography (VOCT) is a new non-invasive and non- destructive technique that can be used to image and measure the mechanical properties of skin. The technique uses infrared light and audible sound to image and measure the resonant frequency of tissue components. The stiffness (modulus) of each major tissue component is obtained from a calibration equation using values of the measured resonant frequency and tissue thickness. VOCT is used in this study to quantitatively compare the outcomes of cell proliferation and fibrous collagen deposition as a result of (1) a skin topical treatment (CE Ferulic) and (2) micro-needle roller application to human forehead skin. Both methods appear to quantitatively increase the ratio of cells to dermal collagen and the ratio of fibrotic collagen to dermal collagen with increasing time. Both chemical and mechanical treatments lead to cell proliferation and new collagen deposition using these skin rejuvenation procedures. While results obtained with micro-needle rolling are achieved more rapidly, collagen deposition with the topical is achieved painlessly. The new collagen that is deposited, using both methods, appears similar to that seen in wound healing and has a higher resonant frequency and modulus compared to normal dermal collagen. The results of this study suggest that VOCT can provide useful quantitative data to evaluate the efficacy of skin rejuvenation procedures. It is suggested that there is a need to develop techniques to regenerate normal dermal collagen as opposed to fibrotic collagen to reduce the stiffness of the new tissue formed.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78967180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.15406/JDC.2020.04.00167
A. Gámbaro
Objective: Clinical evaluation of the efficacy of a treatment for facial skin through a cream which contains Bee Venom (BV). Methods: BV was added to a cream for treating facial skin as an active component. Dosification of the melittin contents of BV was previously done. A medical cosmetologist performed the skin evaluation of 30 volunteers, who passed a BV irritation test and non-inclusion criteria. The clinical evaluation was carried out by evaluating the appearance of the state of skin by means of different indexes and quantifying fifteen attributes of the skin with 9-point scales, before starting the treatment, at 14 and 28 days. Results: Participants were sorted in two clusters (C1 and C2) taking into account their skin state at the beginning of the study. Clusters were differentiated in age and photodamage, resulting that C2 participants were with better skin conditions. During treatment, both clusters increased their hydration, smoothness, firmness, lightness, youthful appearance, healthy appearance and general state of the skin. Moreover, C1 presented a decrease in depth of facial wrinkles and C2 an increase in elasticity and facial oval definition. The volunteers showed an excellent tolerance to treatment and high scores of satisfaction. Conclusion: The methology that was used resulted suitable in classifying facial skin of the volunteers as well as assessing the treatment outcomes using a cream with BV during 28 days. The BV, as an active cosmetic, contributed to improve the state of facial skin.
{"title":"Clinical evaluation of the efficacy of bee venom as cosmetic active","authors":"A. Gámbaro","doi":"10.15406/JDC.2020.04.00167","DOIUrl":"https://doi.org/10.15406/JDC.2020.04.00167","url":null,"abstract":"Objective: Clinical evaluation of the efficacy of a treatment for facial skin through a cream which contains Bee Venom (BV). Methods: BV was added to a cream for treating facial skin as an active component. Dosification of the melittin contents of BV was previously done. A medical cosmetologist performed the skin evaluation of 30 volunteers, who passed a BV irritation test and non-inclusion criteria. The clinical evaluation was carried out by evaluating the appearance of the state of skin by means of different indexes and quantifying fifteen attributes of the skin with 9-point scales, before starting the treatment, at 14 and 28 days. Results: Participants were sorted in two clusters (C1 and C2) taking into account their skin state at the beginning of the study. Clusters were differentiated in age and photodamage, resulting that C2 participants were with better skin conditions. During treatment, both clusters increased their hydration, smoothness, firmness, lightness, youthful appearance, healthy appearance and general state of the skin. Moreover, C1 presented a decrease in depth of facial wrinkles and C2 an increase in elasticity and facial oval definition. The volunteers showed an excellent tolerance to treatment and high scores of satisfaction. Conclusion: The methology that was used resulted suitable in classifying facial skin of the volunteers as well as assessing the treatment outcomes using a cream with BV during 28 days. The BV, as an active cosmetic, contributed to improve the state of facial skin.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77173620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.15406/JDC.2020.04.00170
S. Kadiri
Pyoderma gangrenosum is a non infectious neutrophilic dermatosis with unknown origin. In contrast to its name, PG is neither an infectious nor gangrenous condition. Half of the cases have associated systemic diseases.1 Here in, we report a case of a 46-year-old male with no significant history of malignancies, systemic vasculitis, arthritis, inflammatory bowel disease, fungal infection, drugs, or cutaneous injury was referred to our Department for multiple ulcers appears on the trunk and limbs evolving with relapses and remissions. Clinical examination showed diffusely distributed, two, well-defined, deep purulent ulcers on the back and the calf measuring 4 to 40 cm, with severe oozing and erosions. Laboratory tests revealed a white cell count of 10.23×109/l, hemoglobin 120g/l, and C-reactive protein 12 mg/l. All other tests were normal, including hepatic function tests, renal tests, antinuclear antibodies, anti-neutrophil cytoplasmic antibodies, HIV, hepatitis, and Venereal Disease Research Laboratory test for syphilis. A body scan and colonoscopy were performed and was normal. The patient was treated with systemic glucocorticoids (60mg daily) and topical wound care with partial improvement.
{"title":"Giant and severe pyoderma gangrenosum: about a case","authors":"S. Kadiri","doi":"10.15406/JDC.2020.04.00170","DOIUrl":"https://doi.org/10.15406/JDC.2020.04.00170","url":null,"abstract":"Pyoderma gangrenosum is a non infectious neutrophilic dermatosis with unknown origin. In contrast to its name, PG is neither an infectious nor gangrenous condition. Half of the cases have associated systemic diseases.1 Here in, we report a case of a 46-year-old male with no significant history of malignancies, systemic vasculitis, arthritis, inflammatory bowel disease, fungal infection, drugs, or cutaneous injury was referred to our Department for multiple ulcers appears on the trunk and limbs evolving with relapses and remissions. Clinical examination showed diffusely distributed, two, well-defined, deep purulent ulcers on the back and the calf measuring 4 to 40 cm, with severe oozing and erosions. Laboratory tests revealed a white cell count of 10.23×109/l, hemoglobin 120g/l, and C-reactive protein 12 mg/l. All other tests were normal, including hepatic function tests, renal tests, antinuclear antibodies, anti-neutrophil cytoplasmic antibodies, HIV, hepatitis, and Venereal Disease Research Laboratory test for syphilis. A body scan and colonoscopy were performed and was normal. The patient was treated with systemic glucocorticoids (60mg daily) and topical wound care with partial improvement.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88496781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.15406/jdc.2020.04.00153
D. Smith
The evolution of the mammalian pigment cell, the melanocyte, is linked to the evolution of the neural crest cell (NCC), from which they derive. These cells are a transient, multipotent, migratory cells of ectodermal origin. They are of relatively recent evolutionary origin, found only in vertebrate embryos and represent a highly multipotent population of embryonic stem cells. The particular features of tissues derived from neural crest cells allowed sessile filter-feeding ancestors to evolve into an active, mobile predator, rapidly ascending to the top of the food chain. In particular, the evolution of an animal with a head, containing an osseous jaw with dentition combined with a concentration of advanced sensory systems. This was supported by an improved endocrine system and effective neural transmission from peripheral sensors, allowing fast and reliable regulation of function by the central nervous system (CNS). As a part of this more mobile predatory system the melanocyte provided, at the periphery, both camouflage and a mechanism to monitor and counter the mutagenic effects of increased ultraviolet radiation exposure associated with this more active life-style.
{"title":"The melanocyte in vertebrate evolution","authors":"D. Smith","doi":"10.15406/jdc.2020.04.00153","DOIUrl":"https://doi.org/10.15406/jdc.2020.04.00153","url":null,"abstract":"The evolution of the mammalian pigment cell, the melanocyte, is linked to the evolution of the neural crest cell (NCC), from which they derive. These cells are a transient, multipotent, migratory cells of ectodermal origin. They are of relatively recent evolutionary origin, found only in vertebrate embryos and represent a highly multipotent population of embryonic stem cells. The particular features of tissues derived from neural crest cells allowed sessile filter-feeding ancestors to evolve into an active, mobile predator, rapidly ascending to the top of the food chain. In particular, the evolution of an animal with a head, containing an osseous jaw with dentition combined with a concentration of advanced sensory systems. This was supported by an improved endocrine system and effective neural transmission from peripheral sensors, allowing fast and reliable regulation of function by the central nervous system (CNS). As a part of this more mobile predatory system the melanocyte provided, at the periphery, both camouflage and a mechanism to monitor and counter the mutagenic effects of increased ultraviolet radiation exposure associated with this more active life-style.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83581645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.15406/jdc.2020.04.00160
R. T. Villa
The use of mobile phones has grown rapidly.1 In many countries, the number of telephone lines exceeds the number of inhabitants and, in developing countries, the number of smartphones and the structure of telephony itself expands faster than other elements of infrastructure. The “mobile” nature of telephone, instant access, and direct communication allow the rapid transfer of health information, which supports medical and public health practices, and these are the defining characteristics of “mobile health” or “mHealth”.2
{"title":"Photoprotection and skin self-examination in primary attention users: the impact of smartphone as a tool for education","authors":"R. T. Villa","doi":"10.15406/jdc.2020.04.00160","DOIUrl":"https://doi.org/10.15406/jdc.2020.04.00160","url":null,"abstract":"The use of mobile phones has grown rapidly.1 In many countries, the number of telephone lines exceeds the number of inhabitants and, in developing countries, the number of smartphones and the structure of telephony itself expands faster than other elements of infrastructure. The “mobile” nature of telephone, instant access, and direct communication allow the rapid transfer of health information, which supports medical and public health practices, and these are the defining characteristics of “mobile health” or “mHealth”.2","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74766951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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