Objective — to investigate the effectiveness of different methods of microsporia diagnostics in children. Materials and methods. 50 children aged 2 to 16 (24 boys and 26 girls) were under survey. Depending on the clinical course, diagnosis and research results, all patients were divided into two groups: the 1st group included 40 children with microsporia (19 — with smooth skin microsporia, 13 — with scalp microsporia, 8 — with scalp and smooth skin microsporia); and the 2nd group consisted of 10 children in whom microsporia was not detected. The clinical diagnosis of all patients of the 1st group was confirmed by the results of PCR, microscopic, cultural and luminescent studies. The material for the study was scales from the smooth skin and scalp, as well as hair from the scalp of patients. 10 patients of the 2nd group did not have any clinical manifestations of microsporia and the results of the studies were negative. Results and discussion. The study with PCR in children with microsporia had 100 % positive result. Microsporum canis DNA was detected in all 40 patients. The microscopic method of the study was positive in 95 %. Bacteriological research revealed Microsporum canis in 85 %, while in 15 % the result was negative. Luminescent glow of hair in the rays of the Wood lamp in our study was observed in 87.5 % patients, while in 12.5 % it was absent. Conclusions. The study found that the most effective and accurate method is PCR. This is a method of modern accurate specific diagnostics of microsporia which allows the identification of the pathogen of Microsporum canis at the DNA level. Microscopic, cultural and luminescent research methods can also be used to diagnose this disease.
{"title":"Research of efficiency of microsporia diagnostics methods","authors":"S. Lavrushko, V. Stepanenko","doi":"10.30978/ujdvk2021-3-21","DOIUrl":"https://doi.org/10.30978/ujdvk2021-3-21","url":null,"abstract":"Objective — to investigate the effectiveness of different methods of microsporia diagnostics in children. \u0000Materials and methods. 50 children aged 2 to 16 (24 boys and 26 girls) were under survey. Depending on the clinical course, diagnosis and research results, all patients were divided into two groups: the 1st group included 40 children with microsporia (19 — with smooth skin microsporia, 13 — with scalp microsporia, 8 — with scalp and smooth skin microsporia); and the 2nd group consisted of 10 children in whom microsporia was not detected. The clinical diagnosis of all patients of the 1st group was confirmed by the results of PCR, microscopic, cultural and luminescent studies. The material for the study was scales from the smooth skin and scalp, as well as hair from the scalp of patients. 10 patients of the 2nd group did not have any clinical manifestations of microsporia and the results of the studies were negative. \u0000Results and discussion. The study with PCR in children with microsporia had 100 % positive result. Microsporum canis DNA was detected in all 40 patients. The microscopic method of the study was positive in 95 %. Bacteriological research revealed Microsporum canis in 85 %, while in 15 % the result was negative. Luminescent glow of hair in the rays of the Wood lamp in our study was observed in 87.5 % patients, while in 12.5 % it was absent. \u0000Conclusions. The study found that the most effective and accurate method is PCR. This is a method of modern accurate specific diagnostics of microsporia which allows the identification of the pathogen of Microsporum canis at the DNA level. Microscopic, cultural and luminescent research methods can also be used to diagnose this disease.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78770230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective — to increase the effectiveness of treatment of psoriasis patients with degenerative changes in the nails, by including in the complex therapy of the topical drug Onychocid® Emtrix, aimed at restoring the integrity of the nail plates. Materials and methods. 38 patients with psoriasis and various forms of onychodystrophy (OD) were examined and treated. The effectiveness of therapy was evaluated based on the results of treatment of patients who were divided into two clinical groups — the main and the comparison ones. Patients in both groups received basic therapy. In addition, patients of the main group were prescribed a combined drug Onychocid® Emtrix, which was applied on the nail plates and under the tips of damaged nails once a day for 3 – 6 months. Results and discussion. Patients with psoriasis are diagnosed with dystrophic changes of nail plates of varying severity. OD of the fingers only was detected in 14 (36.8 %) patients; toes — in 5 (13.2 %); fingers and toes at the same time — in 19 (50.0 %) patients. As a result of complex treatment, in patients of the main group there was an early (already on the 2—4th week of use of the drug Onychocid® Emtrix) improvement of the appearance of deformed nails. After the course of treatment, these patients showed a positive clinical effect, i. e. decrease in thickness, normalization of density, color and structure of nail plates. At the same time, «significant improvement» and «improvement» were noted in 34 (89.5 %), «slight improvement» — in 3 (7.9 %), «no improvement» — in 1 (2.6 %) patients. Conclusions. Treatment of psoriasis patients with dystrophic nail lesions should be complex and focused, including the restoration of the integrity of the nail plates. The inclusion in the complex therapy of patients with psoriatic OD of the combined drug Onychocid® Emtrix increases the effectiveness of treatment, in particular, helps to restore the structure, shape, integrity, thickness and color of the nail plates.
{"title":"Ways to increase the effectiveness of treatment of psoriasis patients with dystrophic lesions of the nail plates","authors":"T. Lytynska, L. Naumova","doi":"10.30978/ujdvk2021-3-48","DOIUrl":"https://doi.org/10.30978/ujdvk2021-3-48","url":null,"abstract":"Objective — to increase the effectiveness of treatment of psoriasis patients with degenerative changes in the nails, by including in the complex therapy of the topical drug Onychocid® Emtrix, aimed at restoring the integrity of the nail plates. \u0000Materials and methods. 38 patients with psoriasis and various forms of onychodystrophy (OD) were examined and treated. The effectiveness of therapy was evaluated based on the results of treatment of patients who were divided into two clinical groups — the main and the comparison ones. Patients in both groups received basic therapy. In addition, patients of the main group were prescribed a combined drug Onychocid® Emtrix, which was applied on the nail plates and under the tips of damaged nails once a day for 3 – 6 months. \u0000Results and discussion. Patients with psoriasis are diagnosed with dystrophic changes of nail plates of varying severity. OD of the fingers only was detected in 14 (36.8 %) patients; toes — in 5 (13.2 %); fingers and toes at the same time — in 19 (50.0 %) patients. As a result of complex treatment, in patients of the main group there was an early (already on the 2—4th week of use of the drug Onychocid® Emtrix) improvement of the appearance of deformed nails. After the course of treatment, these patients showed a positive clinical effect, i. e. decrease in thickness, normalization of density, color and structure of nail plates. At the same time, «significant improvement» and «improvement» were noted in 34 (89.5 %), «slight improvement» — in 3 (7.9 %), «no improvement» — in 1 (2.6 %) patients. \u0000Conclusions. Treatment of psoriasis patients with dystrophic nail lesions should be complex and focused, including the restoration of the integrity of the nail plates. The inclusion in the complex therapy of patients with psoriatic OD of the combined drug Onychocid® Emtrix increases the effectiveness of treatment, in particular, helps to restore the structure, shape, integrity, thickness and color of the nail plates.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90767566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The COVID-19 pandemic, political and economic factors, the latest technological advances, environmental changes in the world — all this significantly influenced the awareness of the quality of life by most of the population. For us, as clinicians and lecturers of the Department of Dermatology and Venereology with a course of cosmetology at Bogomolets National Medical University, this became obvious after the forced abandonment of the usual «live» teaching and the transition to distance learning at Zoom in March 2020, and at the same time the re-profiling of the clinical base of the department for inpatient treatment of only COVID-19 patients with the simultaneous discharge of specialized dermatological patients.During the pandemic, we were in fact deprived of the possibility of further professional contact with specialized patients with dermatological diseases. We only had the technical ability to contact the 4th year students of NMU online. It was decided to take advantage of this opportunity not only for their distance teaching of the basics of dermatovenerology, but also for determining (clarifying) their psychostatus with the help of appropriate tests. Objective — to conduct a remote monitoring study of the quality of life (QOL) indicators in young medical workers (students) against the background of the negative informative influence of the media due to the forced long-term stay in a stressful situation of lockdown and strict multi-week quarantine caused by the COVID19 pandemic. Materials and methods. QOL was assessed using the Health Status Survey (SF36) which is one of general (non-specialized) questionnaires. Results and discussion. During the period from March to June, there were noticeable changes in the self-esteem of somatically quite healthy fourth-year medical students of their own QOL, both on several SF-36 scales and in general. This was despite the fact that none of them and their family members were infected with COVID-19 or had any clinical manifestations of this disease for all 3 months. In general, during this time, the existing changes were negative, albeit to varying degrees, according to individual scales. In conditions of remote contact, it became technically possible and scientifically justified to use questionnaires to determine QOL in statistically significant samples of voluntary respondents. Conclusions. We find it hypothetically possible to consider changes in QOL self-esteem in general and according to individual SF-36 scales as a kind of unconventional but quite objective and visual diagnostic test for preclinical (early) determination of the threat of formation and development of psychosomatic disorders in any adult patient who saw a family doctor.
{"title":"Monitoring quality of life in the first halfyear period of coronaviral infodemy in Ukraine","authors":"O. Fedorenko, K.V. Koladenko, L. Sologub","doi":"10.30978/ujdvk2021-3-4","DOIUrl":"https://doi.org/10.30978/ujdvk2021-3-4","url":null,"abstract":"The COVID-19 pandemic, political and economic factors, the latest technological advances, environmental changes in the world — all this significantly influenced the awareness of the quality of life by most of the population. For us, as clinicians and lecturers of the Department of Dermatology and Venereology with a course of cosmetology at Bogomolets National Medical University, this became obvious after the forced abandonment of the usual «live» teaching and the transition to distance learning at Zoom in March 2020, and at the same time the re-profiling of the clinical base of the department for inpatient treatment of only COVID-19 patients with the simultaneous discharge of specialized dermatological patients.During the pandemic, we were in fact deprived of the possibility of further professional contact with specialized patients with dermatological diseases. We only had the technical ability to contact the 4th year students of NMU online. It was decided to take advantage of this opportunity not only for their distance teaching of the basics of dermatovenerology, but also for determining (clarifying) their psychostatus with the help of appropriate tests. \u0000Objective — to conduct a remote monitoring study of the quality of life (QOL) indicators in young medical workers (students) against the background of the negative informative influence of the media due to the forced long-term stay in a stressful situation of lockdown and strict multi-week quarantine caused by the COVID19 pandemic. \u0000Materials and methods. QOL was assessed using the Health Status Survey (SF36) which is one of general (non-specialized) questionnaires. \u0000Results and discussion. During the period from March to June, there were noticeable changes in the self-esteem of somatically quite healthy fourth-year medical students of their own QOL, both on several SF-36 scales and in general. This was despite the fact that none of them and their family members were infected with COVID-19 or had any clinical manifestations of this disease for all 3 months. In general, during this time, the existing changes were negative, albeit to varying degrees, according to individual scales. In conditions of remote contact, it became technically possible and scientifically justified to use questionnaires to determine QOL in statistically significant samples of voluntary respondents. \u0000Conclusions. We find it hypothetically possible to consider changes in QOL self-esteem in general and according to individual SF-36 scales as a kind of unconventional but quite objective and visual diagnostic test for preclinical (early) determination of the threat of formation and development of psychosomatic disorders in any adult patient who saw a family doctor.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79280292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diabetes mellitus (DM) is a frequent metabolic disease whose prevalence is estimated to be around 9.3 % in the world population in the age group 20—79, corresponding to 463 million affected subjects. Moreover, this prevalence will probably increase in the course of the next years. It accounts for more than 90% of the diabetic patients. Besides systemic complications, those ay also be observed in dermatology. According to the region, the prevalence of skin disorders in patients suffering DM is ranging from 35.4 to 98.8 %. This makes these symptoms a frequent cause of consultation in dermatological practice. The most occurring disorders are skin infections, but yellow nails, candidiasis, acrochordons, limited joint mobility and idiopathic guttate hypomelanosis may also be frequently observed. Diabetic dermopathy and diabetic foot syndrome are also common, such as pigmentation disorders such as acanthosis nigricans and vitiligo. Differences between patterns of lesions remain unclear among types of DM (type 1 or type 2). Overall, cutaneous infection and xerosis showed to be highly prevalent and important skin disorders in several studies, regardless DM type. Among cutaneous infections, fungal aetiology appears to be the most common and those with bacterial origin are the less frequent.DM affects the skin through several mechanisms — High levels of glycaemia strongly affect skin homeostasis by impairing the normal functioning of keratinocytes in vitro, decreasing their proliferation and differentiation. They also lead to advanced glycation end products (AGEs) formation. The latter are formed from glycation of proteins, lipids and nucleic acids. They have various deleterious effects at skin levels: inducing reactive oxygen species (ROS) formation, impairing ROS clearance, as well as intra and extracellular proteins function, and inducing pro inflammatory cytokine through nuclear factor κβ (NF-κβ) pathway. AGE alters collagen properties, decreasing flexibility and solubility and increasing its rigidity, thickening dermal collagen, with increased cross linking from non-enzymatic glycosylation, participating in the development of fibrosis. In diabetic patients, the vascular changes found in the skin are similar to those caused by UV-exposure, i. e. thickening of the vessels walls, increasing from thigh to foot and most marked in the capillaries and leading to failure of vascular responsivenessThis paper is aimed to summarize all these pathologies, reporting their prevalence, giving a brief description of the symptoms, of their pathogenesis and guidelines for their management. Dermatologists have a key role in their treatment, but also in detecting new cases of DM when taking in charge these pathologies. They must also promote glycaemic control by these patients.
{"title":"Skin disorders in patients with diabetes mellitus: a review","authors":"C. Diehl","doi":"10.30978/ujdvk2021-3-54","DOIUrl":"https://doi.org/10.30978/ujdvk2021-3-54","url":null,"abstract":"Diabetes mellitus (DM) is a frequent metabolic disease whose prevalence is estimated to be around 9.3 % in the world population in the age group 20—79, corresponding to 463 million affected subjects. Moreover, this prevalence will probably increase in the course of the next years. It accounts for more than 90% of the diabetic patients. Besides systemic complications, those ay also be observed in dermatology. According to the region, the prevalence of skin disorders in patients suffering DM is ranging from 35.4 to 98.8 %. This makes these symptoms a frequent cause of consultation in dermatological practice. The most occurring disorders are skin infections, but yellow nails, candidiasis, acrochordons, limited joint mobility and idiopathic guttate hypomelanosis may also be frequently observed. Diabetic dermopathy and diabetic foot syndrome are also common, such as pigmentation disorders such as acanthosis nigricans and vitiligo. Differences between patterns of lesions remain unclear among types of DM (type 1 or type 2). Overall, cutaneous infection and xerosis showed to be highly prevalent and important skin disorders in several studies, regardless DM type. Among cutaneous infections, fungal aetiology appears to be the most common and those with bacterial origin are the less frequent.DM affects the skin through several mechanisms — High levels of glycaemia strongly affect skin homeostasis by impairing the normal functioning of keratinocytes in vitro, decreasing their proliferation and differentiation. They also lead to advanced glycation end products (AGEs) formation. The latter are formed from glycation of proteins, lipids and nucleic acids. They have various deleterious effects at skin levels: inducing reactive oxygen species (ROS) formation, impairing ROS clearance, as well as intra and extracellular proteins function, and inducing pro inflammatory cytokine through nuclear factor κβ (NF-κβ) pathway. AGE alters collagen properties, decreasing flexibility and solubility and increasing its rigidity, thickening dermal collagen, with increased cross linking from non-enzymatic glycosylation, participating in the development of fibrosis. In diabetic patients, the vascular changes found in the skin are similar to those caused by UV-exposure, i. e. thickening of the vessels walls, increasing from thigh to foot and most marked in the capillaries and leading to failure of vascular responsivenessThis paper is aimed to summarize all these pathologies, reporting their prevalence, giving a brief description of the symptoms, of their pathogenesis and guidelines for their management. Dermatologists have a key role in their treatment, but also in detecting new cases of DM when taking in charge these pathologies. They must also promote glycaemic control by these patients.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84871786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective — to study the molecular mechanisms of the development of actinic keratosis (AK) and compare them with Bowen’s disease. Materials and methods. A literature review, analysis of national and international protocols for the diagnosis of AK are presented, which meet the selection criteria. We reviewed works with at least one recommendation for AK diagnostic scenario published after 2015. The systematic literature review is based on modern studies containing descriptions of molecular diagnostics of certain proto-oncogenes to establish the final diagnosis. Interdisciplinary guidelines were also reviewed to further explore all possible diagnostic criteria. Results and discussion. Until now, the molecular mechanisms of AK development have not been fully studied and grouped into a single review. In most of the sources, only p53 protein was mentioned as the main transcription factor regulating apoptosis. However, recent studies prove a sufficient influence of CD95, which, like p53, induces apoptosis and plays a leading role in the development of AK. All precancerous and malignant neoplasms of the skin arise due to mutations in cells, which cause a violation of apoptosis, but there are still no recommendations and a clear diagnostic algorithm that will allow to quickly establish the final diagnosis and make a choice in favor of this or another method of treatment. Conclusions. AK and Bowen’s disease are different stages in the development of the same malignant process, differing in the proliferative activity of cells and the expression of proto-oncogenes CD95, bcl-2, and p16 which can be used as differential diagnostic markers. Thanks to early diagnosis, it is possible to choose the most suitable treatment option, with consideration for modern protocols.
{"title":"Analysis of molecular mechanisms of development of actinic keratosis: a review","authors":"Yu.V. Tepliuk","doi":"10.30978/ujdvk2021-3-66","DOIUrl":"https://doi.org/10.30978/ujdvk2021-3-66","url":null,"abstract":"Objective — to study the molecular mechanisms of the development of actinic keratosis (AK) and compare them with Bowen’s disease. \u0000Materials and methods. A literature review, analysis of national and international protocols for the diagnosis of AK are presented, which meet the selection criteria. We reviewed works with at least one recommendation for AK diagnostic scenario published after 2015. The systematic literature review is based on modern studies containing descriptions of molecular diagnostics of certain proto-oncogenes to establish the final diagnosis. Interdisciplinary guidelines were also reviewed to further explore all possible diagnostic criteria. \u0000Results and discussion. Until now, the molecular mechanisms of AK development have not been fully studied and grouped into a single review. In most of the sources, only p53 protein was mentioned as the main transcription factor regulating apoptosis. However, recent studies prove a sufficient influence of CD95, which, like p53, induces apoptosis and plays a leading role in the development of AK. All precancerous and malignant neoplasms of the skin arise due to mutations in cells, which cause a violation of apoptosis, but there are still no recommendations and a clear diagnostic algorithm that will allow to quickly establish the final diagnosis and make a choice in favor of this or another method of treatment. \u0000Conclusions. AK and Bowen’s disease are different stages in the development of the same malignant process, differing in the proliferative activity of cells and the expression of proto-oncogenes CD95, bcl-2, and p16 which can be used as differential diagnostic markers. Thanks to early diagnosis, it is possible to choose the most suitable treatment option, with consideration for modern protocols.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82816816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective — to study the clinical efficacy and safety of Betasalic, Triacutan and Psoricap drugs in the treatment of patients with seborrheic dermatitis. Materials and methods. The study included 75 patients with seborrheic dermatitis (main group). The control group consisted of 56 healthy individuals of the same age. The severity of seborrheic dermatitis in patients was assessed on a point scale, which included the assessment of the intensity of erythema, edema, oozing lesions, excoriation, scaling, skin oiliness. The study of skin microbiocenosis was carried out by the method of its direct qualitative and quantitative assessment. The level of anxiety was assessed using the Spielberger—Khanin self-assessment scale. Depending on the proposed treatment, patients with seborrheic dermatitis were divided into 2 groups: Group I (experimental group) — 43 patients who received Betasalic for 5 days, Triacutan — for 5 days, Psoricap — for 18 days starting from the 11th day of therapy; Group II (comparison group) — 32 patients who received topical corticosteroids. Results and discussion. The course of seborrheic dermatitis is accompanied by disorders of the skin microbiocenosis with an increase in the number of fungi of Malassezia and Candida genus in the affected areas, which requires appropriate treatment. Patients with seborrheic dermatitis are characterized by the presence of high personal and situational anxiety. The inclusion of Betasalic and Triacutan in the standard therapy of seborrheic dermatitis contributed to the recovery of the majority of patients and a significant improvement in different localizations of the pathological process. In contrast to the experimental subgroup, in the subgroup with standard treatment, these rates were significantly lower. Additional inclusion of Psoricap in the treatment regimen of patients with seborrheic dermatitis led to the recovery of 100 % of patients with the localization of the pathological process on the scalp and face. Conclusions. Complex therapy of seborrheic dermatitis with the use of Betasalic ointment, Triacutan cream or ointment and Psoricap cream is pathogenetically proved, since it provides a quick clinical effect, normalization of skin microbiocenosis.
{"title":"Seborrheic dermatitis: the choice of topical treatment tactics, taking into account the characteristics of the skin microbiome","authors":"N. Reznichenko, Y. Reznichenko, O. Veretelnyk","doi":"10.30978/ujdvk2021-3-39","DOIUrl":"https://doi.org/10.30978/ujdvk2021-3-39","url":null,"abstract":"Objective — to study the clinical efficacy and safety of Betasalic, Triacutan and Psoricap drugs in the treatment of patients with seborrheic dermatitis. \u0000Materials and methods. The study included 75 patients with seborrheic dermatitis (main group). The control group consisted of 56 healthy individuals of the same age. The severity of seborrheic dermatitis in patients was assessed on a point scale, which included the assessment of the intensity of erythema, edema, oozing lesions, excoriation, scaling, skin oiliness. The study of skin microbiocenosis was carried out by the method of its direct qualitative and quantitative assessment. The level of anxiety was assessed using the Spielberger—Khanin self-assessment scale. Depending on the proposed treatment, patients with seborrheic dermatitis were divided into 2 groups: Group I (experimental group) — 43 patients who received Betasalic for 5 days, Triacutan — for 5 days, Psoricap — for 18 days starting from the 11th day of therapy; Group II (comparison group) — 32 patients who received topical corticosteroids. \u0000Results and discussion. The course of seborrheic dermatitis is accompanied by disorders of the skin microbiocenosis with an increase in the number of fungi of Malassezia and Candida genus in the affected areas, which requires appropriate treatment. Patients with seborrheic dermatitis are characterized by the presence of high personal and situational anxiety. The inclusion of Betasalic and Triacutan in the standard therapy of seborrheic dermatitis contributed to the recovery of the majority of patients and a significant improvement in different localizations of the pathological process. In contrast to the experimental subgroup, in the subgroup with standard treatment, these rates were significantly lower. Additional inclusion of Psoricap in the treatment regimen of patients with seborrheic dermatitis led to the recovery of 100 % of patients with the localization of the pathological process on the scalp and face. \u0000Conclusions. Complex therapy of seborrheic dermatitis with the use of Betasalic ointment, Triacutan cream or ointment and Psoricap cream is pathogenetically proved, since it provides a quick clinical effect, normalization of skin microbiocenosis.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90324587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective — to аssess the impact of dermatosis on the quality of life of children with psoriasis. Materials and methods. Psoriasis severity indices (BSA, PASI, PGA) and dermatological life quality indices (DLQI, CDLQI) in children with psoriasis aged 4 to 17 years depending on the clinical and epidemiological features of dermatosis were determined. A correlation analysis of the presence of a relationship between the obtained indicators was carried out. Results and discussion. In 73.81 % of children, the BSA index was higher than 10, which provided an average BSA of 25.85 (8.78—38.38). The calculated PASI index at the beginning of treatment averaged 9.3 (3.6—18.9). 53.06 % of children had PASI < 10. The PASI index at the first diagnosis was almost 1.5 times lower than in relapses (p = 0.043). The average PGA index was 3 (2—3), namely, 32.99 % of children had PGA 1—2, 43.20 % had PGA 3 and 23.81 % of children had PGA 4. In the group of children aged 4—7 years, there was the smallest number of participants with the PGA index 4 (7.69 %), while in the group aged 16/17—17 years, this number was the largest (41.49 %) (p = 0.039). The calculated DLQI in children with psoriasis was 5 [3—9]. The average DLQI indicator in the group of girls was statistically higher than in the group of boys (p = 0.016). Statistically significant differences were identified between DLQI in the age groups, where the highest impact on quality of life was found for the children aged 16—17 years (p < 0.001) and depended on the clinical form of psoriasis: in scalp psoriasis, the impact on quality of life was moderate, and in inverse psoriasis, it was insignificant (p = 0.021). It was found that in moderatesevere/severe psoriasis, the impact on the quality of life in children increased and was assessed as moderate, while in mild psoriasis, the impact was assessed as minor (p < 0.05). Conclusions. The course of psoriasis in children can be assessed as moderate and severe, but in the first episodes of psoriasis in droplet and inverse forms, the course is mostly mild. The intensity of skin manifestations increases with age, especially in case of the disease recurrences in the plaque form. On the whole in children, psoriasis has an ambiguous impact on the quality of life: in boys, the impact of the disease is minor; in girls, it is moderate. Damage to the visible skin areas caused by psoriasis, an increase in the area affected by the pathological process and an increase in the intensity of skin manifestations with age leads to a more negative impact on the quality of life of a child.
{"title":"Relationships between psoriasis severity indices and dermatological life quality index in children with psoriasis","authors":"Е.О. Murzina, Yu.А. Rokhletsova","doi":"10.30978/ujdvk2021-3-11","DOIUrl":"https://doi.org/10.30978/ujdvk2021-3-11","url":null,"abstract":"Objective — to аssess the impact of dermatosis on the quality of life of children with psoriasis. \u0000Materials and methods. Psoriasis severity indices (BSA, PASI, PGA) and dermatological life quality indices (DLQI, CDLQI) in children with psoriasis aged 4 to 17 years depending on the clinical and epidemiological features of dermatosis were determined. A correlation analysis of the presence of a relationship between the obtained indicators was carried out. \u0000Results and discussion. In 73.81 % of children, the BSA index was higher than 10, which provided an average BSA of 25.85 (8.78—38.38). The calculated PASI index at the beginning of treatment averaged 9.3 (3.6—18.9). 53.06 % of children had PASI < 10. The PASI index at the first diagnosis was almost 1.5 times lower than in relapses (p = 0.043). The average PGA index was 3 (2—3), namely, 32.99 % of children had PGA 1—2, 43.20 % had PGA 3 and 23.81 % of children had PGA 4. In the group of children aged 4—7 years, there was the smallest number of participants with the PGA index 4 (7.69 %), while in the group aged 16/17—17 years, this number was the largest (41.49 %) (p = 0.039). The calculated DLQI in children with psoriasis was 5 [3—9]. The average DLQI indicator in the group of girls was statistically higher than in the group of boys (p = 0.016). Statistically significant differences were identified between DLQI in the age groups, where the highest impact on quality of life was found for the children aged 16—17 years (p < 0.001) and depended on the clinical form of psoriasis: in scalp psoriasis, the impact on quality of life was moderate, and in inverse psoriasis, it was insignificant (p = 0.021). It was found that in moderatesevere/severe psoriasis, the impact on the quality of life in children increased and was assessed as moderate, while in mild psoriasis, the impact was assessed as minor (p < 0.05). \u0000Conclusions. The course of psoriasis in children can be assessed as moderate and severe, but in the first episodes of psoriasis in droplet and inverse forms, the course is mostly mild. The intensity of skin manifestations increases with age, especially in case of the disease recurrences in the plaque form. On the whole in children, psoriasis has an ambiguous impact on the quality of life: in boys, the impact of the disease is minor; in girls, it is moderate. Damage to the visible skin areas caused by psoriasis, an increase in the area affected by the pathological process and an increase in the intensity of skin manifestations with age leads to a more negative impact on the quality of life of a child.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89517154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Fedorych, A.Ye. Alatorskykh, L. Hrechanska, S. V. Ivanov
Acne is an urgent problem in modern dermatology. The management of this disease is a complex, lengthy and multi-step process that requires a combination of different treatment methods and an individualized approach. Objeсtive — to demonstrate a clinical case of effective treatment of acne in a patient with secondary immune deficiency of the first degree. Materials and methods. A clinical case is presented of treatment of a 23-year-old man suffering from papulopustular form of moderate acne developed on the background of secondary immune deficiency of the first degree. The disease had a chronic course and resistance to the therapy used. The retinoid drug isotretinoin was used for treatment with a gradual increase and then decrease in its daily dose; antibiotic therapy; the drug Propes as an immunomodulator; as well as a set of cosmetic measures — chemical peelings and laser skin resurfacing. After the onset of dryness of certain areas of the skin, as a side effect of isotretinoin, emollients were locally intended. Results and discussion. At the end of the seventh month of treatment, the inflammatory rash on the skin completely stopped. The phenomenon of postacne was eliminated. During the control immunogram 2 months after the start of complex therapy, there was complete normalization of its parameters. In addition, during the first month of taking the drug isotretinoin , the patient did not have the exacerbation of the inflammatory process on the skin which was usual for this stage of treatment. Conclusions. The success in the treatment of the patient with acne who had secondary immune deficiency of the first degree as concomitant pathology, in our opinion, is due to a wellchosen comprehensive treatment which included antibacterial therapy, systemic retinoid isotretinoin in an appropriate for this clinical stage dose, Propes medication of the defensins group as an immunomodulatory agent, as well as the use of a complex of cosmetic measures.
{"title":"A саsе of effective treatment of acne in patient with secondary immune deficiency of the first degree","authors":"P. Fedorych, A.Ye. Alatorskykh, L. Hrechanska, S. V. Ivanov","doi":"10.30978/ujdvk2021-3-27","DOIUrl":"https://doi.org/10.30978/ujdvk2021-3-27","url":null,"abstract":"Acne is an urgent problem in modern dermatology. The management of this disease is a complex, lengthy and multi-step process that requires a combination of different treatment methods and an individualized approach. \u0000Objeсtive — to demonstrate a clinical case of effective treatment of acne in a patient with secondary immune deficiency of the first degree. \u0000Materials and methods. A clinical case is presented of treatment of a 23-year-old man suffering from papulopustular form of moderate acne developed on the background of secondary immune deficiency of the first degree. The disease had a chronic course and resistance to the therapy used. The retinoid drug isotretinoin was used for treatment with a gradual increase and then decrease in its daily dose; antibiotic therapy; the drug Propes as an immunomodulator; as well as a set of cosmetic measures — chemical peelings and laser skin resurfacing. After the onset of dryness of certain areas of the skin, as a side effect of isotretinoin, emollients were locally intended. \u0000Results and discussion. At the end of the seventh month of treatment, the inflammatory rash on the skin completely stopped. The phenomenon of postacne was eliminated. During the control immunogram 2 months after the start of complex therapy, there was complete normalization of its parameters. In addition, during the first month of taking the drug isotretinoin , the patient did not have the exacerbation of the inflammatory process on the skin which was usual for this stage of treatment. \u0000Conclusions. The success in the treatment of the patient with acne who had secondary immune deficiency of the first degree as concomitant pathology, in our opinion, is due to a wellchosen comprehensive treatment which included antibacterial therapy, systemic retinoid isotretinoin in an appropriate for this clinical stage dose, Propes medication of the defensins group as an immunomodulatory agent, as well as the use of a complex of cosmetic measures.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76743597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective — to highlight the issue of difficulties in the diagnosis and treatment of patients with pyoderma gangrenosum (PG). Materials and methods. A literature review and analysis of the results of the clinical examination of patients with PG was performed. Pyoderma gangrenosum is most commonly observed in young and middle-aged people, more frequently in women. The pathogenesis of PG has not been fully studied. It is believed to be related to genetic mutations, neutrophil dysfunction and impaired immunity/inflammation regulation. Maverakis and others developed diagnostic criteria for PG. First-line treatment is aimed at optimizing the local wound care. For more severe diseases, systemic therapy is required. Oral corticosteroids (0.5—1 mg/kg/day) are the basis of treatment and used for control of PG. Cyclosporine can be used either alone or in combination with corticosteroids. At present, there is an increasing evidence of effectiveness of biological therapy as treatment method for a number of cytokines. Results and discussion. This article presents a clinical case of a patient diagnosed with PG. Based on recent guidelines, systemic corticosteroid therapy (Medrol starting at 48 mg/d), systemic anti-inflammatory and vascular drugs, topical therapy and treatment results were presented. Conclusions. Without treatment, the disease lasts for months and years. Ulcers sometimes grow very fast, reaching huge sizes in a matter of days. After the healing of some ulcers new ones often emerge. Pain syndrome, the addition of a secondary infection and the continuous progression of the pathological process lead to a decrease in the patient’s quality of life, as well as to a deterioration in his social adaptation. Therefore, timely adequate diagnosis, treatment and full compliance of the patient are the key to success.
{"title":"Clinical case of pyodermia ulcerosa serpiginosa(pyoderma gangrenosum)","authors":"L. Verbytska, D. A. Kinash","doi":"10.30978/ujdvk2021-3-32","DOIUrl":"https://doi.org/10.30978/ujdvk2021-3-32","url":null,"abstract":"Objective — to highlight the issue of difficulties in the diagnosis and treatment of patients with pyoderma gangrenosum (PG).\u0000Materials and methods. A literature review and analysis of the results of the clinical examination of patients with PG was performed. Pyoderma gangrenosum is most commonly observed in young and middle-aged people, more frequently in women. The pathogenesis of PG has not been fully studied. It is believed to be related to genetic mutations, neutrophil dysfunction and impaired immunity/inflammation regulation. Maverakis and others developed diagnostic criteria for PG. First-line treatment is aimed at optimizing the local wound care. For more severe diseases, systemic therapy is required. Oral corticosteroids (0.5—1 mg/kg/day) are the basis of treatment and used for control of PG. Cyclosporine can be used either alone or in combination with corticosteroids. At present, there is an increasing evidence of effectiveness of biological therapy as treatment method for a number of cytokines. \u0000Results and discussion. This article presents a clinical case of a patient diagnosed with PG. Based on recent guidelines, systemic corticosteroid therapy (Medrol starting at 48 mg/d), systemic anti-inflammatory and vascular drugs, topical therapy and treatment results were presented.\u0000Conclusions. Without treatment, the disease lasts for months and years. Ulcers sometimes grow very fast, reaching huge sizes in a matter of days. After the healing of some ulcers new ones often emerge. Pain syndrome, the addition of a secondary infection and the continuous progression of the pathological process lead to a decrease in the patient’s quality of life, as well as to a deterioration in his social adaptation. Therefore, timely adequate diagnosis, treatment and full compliance of the patient are the key to success.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75326718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stretch marks (SM) feature visible linear scars developing on the body in the areas of excessive stretching of the skin. This is a benign skin condition, but because of their aesthetic implications, they can cause distress among their sufferers. SM show high prevalence, probably more than 50 % among pregnant women, and 50 to 90 % in the general population. SM affect more likely certain ethnic groups, especially dark-skinned patients. During pregnancy, risk factors include family history, but also important weight gain whilst more generally elevated body mass index also constitutes a risk factor. Clinically, the initial erythematous and violaceous lesions referred to as striae rubrae fade into wrinkled, hypo-pigmented, atrophic scar-like marks named striae albae. Four main theories support SM formation: 1) mechanical stretching of the skin; 2) hormonal changes; 3) an innate structural disturbance of the integument; 4) genetic predispositions. Histologically various abnormalities of collagen and elastic fibres are described at dermal level. The treatment of SM is always deceptive. Topical treatments are the commonest, among them Centella asiatica or hyaluronic acid creams, almond oil, topical retinoids, cocoa butter or olive oil are the most popular. Chemical peels may also be used with limited success. Various office procedures may also be performed, such as microdermabrasion, radiofrequency, laser/light therapy, platelet-rich plasma and others, but the results are often limited and deceptive for both the patient and the dermatologist. More remains to be done about the study of this frequent dermatological disorder.
{"title":"Stretch marks: a review","authors":"C. Diehl","doi":"10.30978/ujdvk2021-2-68","DOIUrl":"https://doi.org/10.30978/ujdvk2021-2-68","url":null,"abstract":"Stretch marks (SM) feature visible linear scars developing on the body in the areas of excessive stretching of the skin. This is a benign skin condition, but because of their aesthetic implications, they can cause distress among their sufferers. SM show high prevalence, probably more than 50 % among pregnant women, and 50 to 90 % in the general population. SM affect more likely certain ethnic groups, especially dark-skinned patients. During pregnancy, risk factors include family history, but also important weight gain whilst more generally elevated body mass index also constitutes a risk factor. Clinically, the initial erythematous and violaceous lesions referred to as striae rubrae fade into wrinkled, hypo-pigmented, atrophic scar-like marks named striae albae. Four main theories support SM formation: 1) mechanical stretching of the skin; 2) hormonal changes; 3) an innate structural disturbance of the integument; 4) genetic predispositions. Histologically various abnormalities of collagen and elastic fibres are described at dermal level. The treatment of SM is always deceptive. Topical treatments are the commonest, among them Centella asiatica or hyaluronic acid creams, almond oil, topical retinoids, cocoa butter or olive oil are the most popular. Chemical peels may also be used with limited success. Various office procedures may also be performed, such as microdermabrasion, radiofrequency, laser/light therapy, platelet-rich plasma and others, but the results are often limited and deceptive for both the patient and the dermatologist. More remains to be done about the study of this frequent dermatological disorder.","PeriodicalId":23420,"journal":{"name":"Ukrainian Journal of Dermatology, Venerology, Cosmetology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75307022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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