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Differences in the burden of pediatric pancreatitis across countries and regions: One size does not fit all. 不同国家和地区的小儿胰腺炎负担存在差异：不能 "一刀切"。
IF 5.8 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
United European Gastroenterology Journal
Pub Date : 2024-11-07 DOI: 10.1002/ueg2.12665
Chinenye Rebecca Dike, Sohail Z Husain
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引用次数: 0
Pancreatic cancer surveillance: Risk stratification of individuals with a germline CDKN2A pathogenic variant. 胰腺癌监测：对带有 CDKN2A 基因变异的个体进行风险分层。
IF 5.8 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
United European Gastroenterology Journal
Pub Date : 2024-11-07 DOI: 10.1002/ueg2.12662
Derk C F Klatte, Jihane Meziani, Djuna L Cahen, Merel van Diepen, Marco J Bruno, Monique E van Leerdam

Background: Individuals carrying a germline CDKN2A pathogenic variant (PV) are at a high risk of developing pancreatic ductal adenocarcinoma. Risk stratification could allow tailored surveillance.

Objective: To develop a Fine-Gray prediction model for the risk of PDAC in carriers of a CDKN2A PV.

Methods: Data from two large Dutch pancreatic cancer surveillance programs were used. A limited set of predictor variables were selected bsased on previous literature and the clinical expertise of the study group.

Results: A total of 506 CDKN2A PV carriers were included, among whom we showed a substantial lifetime risk of PDAC (23%). The model identifies having a first-degree relative with PDAC (B = 0.7256) and a history of smoking (B = 0.4776) as significant risk factors. However, the model shows limited discrimination (c-statistic 0.64) and calibration.

Conclusion: Our study highlights the high lifetime risk of PDAC in carriers of a CDKN2A PV. While identifying significant risk factors such as family history of PDAC and smoking, our prediction model shows limited precision, highlighting the need for additional factors such as biomarkers to improve its clinical utility for tailored surveillance of high-risk individuals.

背景：携带种系CDKN2A致病变异体（PV）的人罹患胰腺导管腺癌的风险很高。进行风险分层可实现有针对性的监测：目的：针对 CDKN2A PV 携带者罹患 PDAC 的风险建立 Fine-Gray 预测模型：方法：使用来自荷兰两个大型胰腺癌监测项目的数据。方法：采用荷兰两个大型胰腺癌监测项目的数据，根据以往文献和研究小组的临床专业知识，选择了一组有限的预测变量：结果：共纳入了 506 名 CDKN2A PV 携带者，我们发现他们终生罹患 PDAC 的风险很高（23%）。该模型发现，一级亲属患有 PDAC（B = 0.7256）和吸烟史（B = 0.4776）是重要的风险因素。然而，该模型显示出有限的区分度（c 统计量 0.64）和校准：我们的研究强调了 CDKN2A PV 携带者终生罹患 PDAC 的高风险。我们的预测模型在确定了 PDAC 家族史和吸烟等重要风险因素的同时，也显示出了有限的精确性，这突出表明需要生物标志物等其他因素来提高其临床实用性，以便对高风险个体进行有针对性的监测。
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引用次数: 0
Multi-OMICs orchestration enabled by artificial intelligence in inflammatory bowel disease: An exciting future. 人工智能在炎症性肠病中实现多 OMICs 协调：令人振奋的未来。
IF 5.8 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
United European Gastroenterology Journal
Pub Date : 2024-11-07 DOI: 10.1002/ueg2.12663
Marietta Iacucci, Giovanni Santacroce
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引用次数: 0
Tofacitinib in chronic pouchitis: A step towards addressing an unmet need. 托法替尼治疗慢性胃袋炎：向满足未满足的需求迈出了一步。
IF 5.8 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
United European Gastroenterology Journal
Pub Date : 2024-11-07 DOI: 10.1002/ueg2.12691
Jacob E Ollech
{"title":"Tofacitinib in chronic pouchitis: A step towards addressing an unmet need.","authors":"Jacob E Ollech","doi":"10.1002/ueg2.12691","DOIUrl":"https://doi.org/10.1002/ueg2.12691","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vedolizumab for Crohn's disease: Real-world efficacy through a meta-analytical lens. 治疗克罗恩病的维多珠单抗：通过荟萃分析透视真实世界的疗效。
IF 5.8 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
United European Gastroenterology Journal
Pub Date : 2024-11-07 DOI: 10.1002/ueg2.12690
Maria Manuela Estevinho, Virginia Solitano
{"title":"Vedolizumab for Crohn's disease: Real-world efficacy through a meta-analytical lens.","authors":"Maria Manuela Estevinho, Virginia Solitano","doi":"10.1002/ueg2.12690","DOIUrl":"https://doi.org/10.1002/ueg2.12690","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Increasing evidence supporting fecal calprotectin for distinguishing Crohn's disease perianal fistulas from cryptoglandular fistulas. 越来越多的证据支持粪便钙蛋白用于区分克罗恩病肛周瘘和隐窝瘘。
IF 5.8 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
United European Gastroenterology Journal
Pub Date : 2024-11-07 DOI: 10.1002/ueg2.12646
Samuel Raimundo Fernandes, Inês Coelho Rodrigues
{"title":"Increasing evidence supporting fecal calprotectin for distinguishing Crohn's disease perianal fistulas from cryptoglandular fistulas.","authors":"Samuel Raimundo Fernandes, Inês Coelho Rodrigues","doi":"10.1002/ueg2.12646","DOIUrl":"https://doi.org/10.1002/ueg2.12646","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatic Artery Aneurysm Rupture After Double-Balloon Endoscopy in Biliary Atresia. 胆道闭锁双气囊内镜检查后肝动脉瘤破裂
IF 5.8 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
United European Gastroenterology Journal
Pub Date : 2024-11-07 DOI: 10.1002/ueg2.12703
Shinya Yokoyama, Shuji Ikegami, Tadashi Iida, Hiroki Kawashima
{"title":"Hepatic Artery Aneurysm Rupture After Double-Balloon Endoscopy in Biliary Atresia.","authors":"Shinya Yokoyama, Shuji Ikegami, Tadashi Iida, Hiroki Kawashima","doi":"10.1002/ueg2.12703","DOIUrl":"https://doi.org/10.1002/ueg2.12703","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insights in the natural course of eosinophilic esophagitis. 嗜酸性粒细胞食管炎自然病程的新见解。
IF 5.8 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
United European Gastroenterology Journal
Pub Date : 2024-11-07 DOI: 10.1002/ueg2.12702
Gwen M C Masclee, Albert Jan Bredenoord
{"title":"New insights in the natural course of eosinophilic esophagitis.","authors":"Gwen M C Masclee, Albert Jan Bredenoord","doi":"10.1002/ueg2.12702","DOIUrl":"https://doi.org/10.1002/ueg2.12702","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence: The researcher's assistant or sheep in wolf's clothing? 人工智能：研究人员的助手还是披着狼皮的羊？
IF 5.8 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
United European Gastroenterology Journal
Pub Date : 2024-11-07 DOI: 10.1002/ueg2.12689
Pisani Anthea, Campani Claudia
{"title":"Artificial intelligence: The researcher's assistant or sheep in wolf's clothing?","authors":"Pisani Anthea, Campani Claudia","doi":"10.1002/ueg2.12689","DOIUrl":"https://doi.org/10.1002/ueg2.12689","url":null,"abstract":"","PeriodicalId":23444,"journal":{"name":"United European Gastroenterology Journal","volume":" ","pages":""},"PeriodicalIF":5.8,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upper gastrointestinal Crohn's disease: What are we talking about? 上消化道克罗恩病：我们在谈论什么？
IF 5.8 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
United European Gastroenterology Journal
Pub Date : 2024-11-07 DOI: 10.1002/ueg2.12664
Luisa Bertin, Brigida Barberio, Edoardo Vincenzo Savarino
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引用次数: 0
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