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Heart failure as the first clinical symptom of amyloidosis 心力衰竭是淀粉样变的首要临床症状
Q4 Medicine Pub Date : 2023-10-10 DOI: 10.36290/vnl.2023.075
František Novák, Jan Václavík
Pojem amyloidóza zahrnuje skupinu poruch, při kterých dochází k ukládání proteinů, přirozených i mutovaných, do tkání. Z těchto proteinů vzniká uspořádaná vláknitá, špatně rozpustná matrix zvaná amyloid. Její ukládání poškozuje funkci postižených orgánů (1, 2). Diagnostika je obtížná a často pozdní (3). Postižení srdce je velmi časté a nejvíce limituje prognózu nemocného (4). Popisujeme případ pacientky, u které ani relativně časná diagnóza srdeční amyloidózy nezabránila jejímu náhlému úmrtí.
淀粉样变性是指蛋白质(包括天然蛋白质和变异蛋白质)沉积在组织中的一组疾病。这些蛋白质形成一种纤维状的高溶性基质,称为淀粉样蛋白。淀粉样蛋白的沉积会损害受影响器官的功能(1,2)。淀粉样变性很难确诊,而且往往很晚才确诊(3)。 心脏受累非常常见,通常会限制患者的预后(4)。 我们描述了一例患者的病例,即使较早诊断出心脏淀粉样变性,也无法阻止她过早死亡。
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引用次数: 0
Rosacea: skin disease or a systemic disorder? 酒渣鼻:皮肤病还是全身性疾病?
Q4 Medicine Pub Date : 2023-10-10 DOI: 10.36290/vnl.2023.082
Štefan Alušík
Rosacea (růžovka) je onemocnění, které má multifaktoriální příčinu a komplexní patofyziologii a která se neomezuje pouze na kůži. V klinické praxi je rosacea spojena s řadou komorbidit a v současné době se vede diskuze o tom, zda není rosacea onemocněním systémovým.
酒糟鼻是一种病因多因素、病理生理学复杂的疾病,并不局限于皮肤。在临床实践中,酒糟鼻与多种并发症相关,目前关于酒糟鼻是否是一种全身性疾病还存在争议。
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引用次数: 0
Endoscopic and surgical therapy for obesity 内窥镜和手术治疗肥胖
Q4 Medicine Pub Date : 2023-10-10 DOI: 10.36290/vnl.2023.079
Jan Král, Filip Doleček, Kateřina Waloszková, Jana Selucká, Evžen Machytka, Julius Špičák, Marek Bužga
Obezita je závažné onemocnění, jehož incidence nadále celosvětově roste. Onemocnění asociovaná s obezitou vedou ke snížení kvality života a vyšší mortalitě (vysoký krevní tlak, dyslipidemie, diabetes mellitus 2. typu a další). Léčba obezity je multidisciplinární a komplexní proces, který vyžaduje důslednou spolupráci pacienta. Změna životního stylu je stavebním kamenem úspěšné terapie obezity. Farmakologická terapie zažívá v posledních letech renesanci a její role, jak už v monoterapii, tak i v kombinaci s jinými metodami, bude postupně nabývat na významu. Endoskopická terapie je rychle se vyvíjecí podobor digestivní endoskopie, která nabízí celou řadu nových metod redukujících například objem žaludku nebo bypass tenkého střeva. Metody jsou efektivní a zároveň mají nízké riziko komplikací. Chirurgická terapie je na druhou stranu vysoce účinná, nicméně je zatížena vyšším výskytem komplikací. Bariatrická chirurgie je určena především pro pacienty s pokročilým stadiem obezity s komorbiditami. Cílem této publikace je dát souhrnný přehled dosavadních endoskopických a chirurgických metod v léčbě obezity.
肥胖症是一种主要疾病,其发病率在全球范围内呈上升趋势。肥胖相关疾病(高血压、血脂异常、2 型糖尿病等)导致生活质量下降,死亡率上升。 肥胖治疗是一个多学科的复杂过程,需要患者的持续参与。改变生活方式是肥胖症治疗的基石。近年来,药物疗法开始复兴,无论是作为单一疗法还是与其他方法结合使用,其重要性都将逐渐增加。内窥镜疗法是消化内窥镜的一个快速发展的子领域,它提供了一系列新方法来减少胃容量或小肠分流术等。这些方法效果显著,并发症风险较低。另一方面,手术治疗非常有效,但并发症发生率较高。减肥手术尤其适用于合并症的晚期肥胖患者。本刊物旨在全面介绍目前治疗肥胖症的内窥镜和外科手术方法。
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引用次数: 0
Point-of-care ultrasonography: a revolution in a daily routine of an internist? 即时超声检查:内科医生日常工作的一场革命?
Q4 Medicine Pub Date : 2023-10-10 DOI: 10.36290/vnl.2023.081
Juraj Smaha, Jakub Falat, Anzhelika Shevchuk, Martin Kužma, Peter Jackuliak, Juraj Payer
Point-of-care ultrasonografia (POCUS) predstavuje formu ultrasonografie, keď ošetrujúci lekár vykonáva ultrasonografické vyšetrenie pri lôžku pacienta v reálnom čase, čo mu umožňuje hodnotiť aj dynamické zmeny USG obrazu a nálezy priamo korelovať so symptómami pacienta. Lekár vykonávajúci POCUS má zvyčajne na mysli konkrétnu klinickú otázku, ktorú si chce sonografickým vyšetrením zodpovedať. POCUS má potenciál zefektívniť diagnostiku, liečbu, monitoring a skríning mnohých ochorení u interne chorých pacientov, jeho postavenie v rámci vnútorného lekárstva však zatiaľ nie je jasne zadefinované. Článok sa venuje potenciálnym výhodám POCUS-u v kontexte vnútorného lekárstva, dátam o využití POCUS-u v reálnej klinickej praxi relevantnej pre internistu a dátam o využití tzv. vreckových USG prístrojov.
护理点超声检查(POCUS)是一种由主治医生在病人床旁实时进行超声检查的超声检查方式,这使得医生甚至可以评估超声图像的动态变化,并将检查结果与病人的症状直接联系起来。执行 POCUS 的医生通常都有一个特定的临床问题,希望通过超声波测量来回答。POCUS 有可能改善内科病人多种疾病的诊断、治疗、监测和筛查,但其在内科中的地位尚未明确界定。本文讨论了 POCUS 在内科领域的潜在优势、POCUS 在与内科医生相关的实际临床实践中的应用以及所谓袖珍超声设备的使用。
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引用次数: 0
Multimorbidity in acute kidney injury 急性肾损伤的多病性
Q4 Medicine Pub Date : 2023-10-10 DOI: 10.36290/vnl.2023.074
Vladimír Teplan
Akutní poškození a selhání ledvin (AKI) je často spojeno s postižením dalších orgánů. Nejčastěji se jedná o postižení kardiální, plicní, jaterní, gastrointestinální, CNS, cévní či kožní. Závažné jsou stavy akutního poškození ledvin při oběhovém selhání a toxicitě, ale i jako následek poruch vodního a elektrolytového metabolismu (hypotenze, krvácení, průjmy, zvracení). Akutní poškození ledvin může být spojeno s hypertenzí, především maligní, ale i s otoky (při velké proteinurii), které mohou být i jiné etiologie (kardiální selhání, cévní záněty, jaterní léze, gastrointestinální postižení, onkologické onemocnění apod.). Polékové a infekční poškození ledvin je také často spojeno s postižením dalších orgánů, jako jsou játra, plíce, cévy, svaly, kostní dřeň apod. Víceorgánové postižení významně modifikuje další léčebné postupy.
急性肾损伤和肾衰竭(AKI)通常与其他器官的损伤有关。最常见的是心脏、肺、肝、胃肠、中枢神经系统、血管或皮肤损伤。循环衰竭和中毒情况下的急性肾损伤,以及水和电解质代谢紊乱(低血压、出血、腹泻、呕吐)导致的急性肾损伤更为常见。急性肾损伤可能与高血压(尤其是恶性肿瘤)有关,也可能与水肿(高蛋白尿)有关、可能有其他病因(心力衰竭、血管疾病、肝脏疾病、胃肠道疾病、肿瘤疾病等)。).多囊肾和感染性肾损害往往还伴有其他器官的损害,如肝、肺、内脏、肌肉、骨骼等。多器官损伤会明显改变其他治疗程序。
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引用次数: 0
Point‑of‑Care Ultrasound in internal medicine. 内科护理点超声。
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.36290/vnl.2023.041
Zdeněk Monhart

Point-of-Care ultrasound (POCUS) is bedside ultrasound examination performed by a clinician. POCUS is a suitable tool for rapid diagnosis and monitoring of the condition of many patients examined by internists in emergency departments and inpatient departments. POCUS allows the examining physician to supplement the physical examination with additional information obtained in real time, and is a useful tool for differential diagnosis of a number of acute conditions (shock, shortness of breath, etc.). Chest POCUS includes an indicative assessment of cardiac function and evaluation of the lung parenchyma, including exclusion of pericardial effusion, pneumothorax or fluidothorax. One of the most common applications of POCUS is to assess the state of the venous filling by examining the inferior vena cava. When examining the abdomen, the internist should at least be able to diagnose fluid in the abdominal cavity and exclude congestion in the hollow system of the kidney. POCUS for internists also includes examination of main venous trunks to rule out proximal venous thrombosis. Even when performing conventional invasive procedures, we cannot do without ultrasound at the bedside, whether it is a puncture of ascites or pleural effusion, or cannulation of the central vein. The advantage of POCUS is the immediate availability of the examination and the possibility to repeat scans when needed for monitoring the patient's condition.

护理点超声检查(POCUS)是由临床医生进行的床边超声检查。POCUS 是内科医生在急诊科和住院部对许多病人进行快速诊断和病情监测的合适工具。POCUS 允许检查医生通过实时获取的额外信息对体格检查进行补充,是对一些急性病(休克、呼吸急促等)进行鉴别诊断的有用工具。胸部 POCUS 包括对心脏功能的指示性评估和对肺实质的评估,包括排除心包积液、气胸或液胸。POCUS 最常见的应用之一是通过检查下腔静脉来评估静脉充盈状态。在检查腹部时,内科医生至少应能诊断出腹腔积液并排除肾脏中空系统充血。内科医生的 POCUS 还包括检查主要静脉干,以排除近端静脉血栓。即使在进行传统的有创手术时,我们也离不开床旁的超声检查,无论是腹水或胸腔积液的穿刺,还是中心静脉的插管。POCUS 的优势在于可立即进行检查,并可在需要时重复扫描,以监测病人的病情。
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引用次数: 0
Ethical aspects in oncology. 肿瘤学的伦理问题
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.36290/vnl.2023.009
Anetta Jedličková

Decisions related to the treatment of oncological diseases bring various ethical dilemmas to healthcare providers caring for cancer patients. Along with the development of medicine and new therapeutic methods, there are also increased demands on the appropriate selection of eligible patients for allocation to a particular treatment method, which causes a number of ethical connotations. The paper deals with ethical issues in the course of oncology treatment, with theoretical bases for ethical decision-making and with ethical aspects of communication with patients suffering from oncological diseases. The paper also contains results of studies that dealt with methods of ethical reasoning of health professionals in relation with the Do Not Resuscitate (DNR) decision in oncology, and with understanding of the concept of ethical competence of health professionals in order to make, or be involved in, DNR decisions, and how relevant skills can be developed. Among others, the results of the studies pointed out that in order to make ethically based DNR decisions in oncology, physicians and nurses need to improve their knowledge of ethical theories.

与治疗肿瘤疾病有关的决定给护理癌症患者的医护人员带来了各种伦理难题。随着医学的发展和新治疗方法的出现,对适当选择符合条件的患者以分配给特定治疗方法的要求也越来越高,这就产生了许多伦理内涵。本文论述了肿瘤治疗过程中的伦理问题、伦理决策的理论基础以及与肿瘤疾病患者沟通的伦理问题。论文还包含一些研究成果,涉及医护专业人员在肿瘤治疗中做出 "不抢救"(DNR)决定时的伦理推理方法,医护专业人员在做出或参与 "不抢救 "决定时对伦理能力概念的理解,以及如何培养相关技能。其中,研究结果表明,为了在肿瘤学领域做出基于伦理的 "DNR "决定,医生和护士需要提高对伦理理论的认识。
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引用次数: 0
Osteoporosis in adults in clinical practice (1): diagnosis and differential diagnosis. 临床实践中的成人骨质疏松症(1):诊断与鉴别诊断。
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.36290/vnl.2023.052
Vít Zikán

Osteoporosis is a systemic metabolic disease of the skeleton characterized by low bone strength that results in an increased risk of fracture. Fractures are associated with serious clinical consequences, including pain, disability, loss of independence, and death, as well as high healthcare costs. Early identification and intervention with patients at high risk for fracture is needed to reduce the burden of osteoporotic fractures. The identification of a patient at high risk of fracture should be followed by evaluation for factors contributing to low bone mineral density (BMD) and/or low bone quality, falls, and fractures. Components of the osteological evaluation include an assessment of BMD by dual-energy X-ray absorptiometry, osteoporosis-directed medical history and physical exam, laboratory studies, and possibly skeletal imaging. Disorders other than osteoporosis, requiring other types of treatment, may be found. This overview summarizes the basic procedures for the diagnosis and differential diagnosis of osteoporosis, which are necessary before starting treatment.

骨质疏松症是一种全身性骨骼代谢疾病,其特点是骨强度低,导致骨折风险增加。骨折会带来严重的临床后果,包括疼痛、残疾、丧失独立能力和死亡,以及高昂的医疗费用。为减轻骨质疏松性骨折的负担,需要及早识别骨折高危患者并对其进行干预。在确定骨折高风险患者后,应评估导致低骨矿物质密度(BMD)和/或低骨质量、跌倒和骨折的因素。骨学评估的内容包括通过双能 X 射线吸收测量法评估 BMD、骨质疏松症导向的病史和体格检查、实验室研究,以及可能的骨骼成像。可能会发现骨质疏松症以外的其他疾病,需要其他类型的治疗。本概述总结了骨质疏松症诊断和鉴别诊断的基本程序,这在开始治疗前是必要的。
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引用次数: 0
What is new in 2022 ESC guidelines on cardiovascular assessment and management of patients undergoing non‑cardiac surgery. 2022年ESC指南中关于接受非心脏手术患者心血管评估和管理的新内容。
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.36290/vnl.2023.002
Bronislav Čapek, Jan Václavík

In 2022, the European Society of Cardiology has published updated guidelines for the cardiovascular evaluation and management of patients undergoing non-cardiac surgery. In this article we briefly summarize the most important recommendations with an emphasis on their use in everyday clinical practice - from the complex assessment of cardiovascular risk and prediction of cardiovascular complications, through the indication of basic paraclinical examinations, the importance of biomarkers, adjustments to pharmacotherapy of heart failure, adjustments to anticoagulant and antiplatelet therapy, to other specifics of individual cardiovascular and other diseases and their importance in the perioperative period. Knowledge and use of these recommendations have the potential to improve the prognosis of patients undergoing various types of surgical procedures.

2022年,欧洲心脏病学会发布了对接受非心脏手术的患者进行心血管评估和管理的最新指南。在这篇文章中,我们简要总结了最重要的建议,并强调了它们在日常临床实践中的应用——从心血管风险的复杂评估和心血管并发症的预测,到基础临床旁检查的指征,生物标志物的重要性,心力衰竭药物治疗的调整,抗凝和抗血小板治疗的调整,个别心血管和其他疾病的其他细节及其在围手术期的重要性。了解和使用这些建议有可能改善接受各种类型手术的患者的预后。
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引用次数: 0
Clinical assessment and management of patients with multimorbidity. 多病患者的临床评估与管理。
Q4 Medicine Pub Date : 2023-01-01 DOI: 10.36290/vnl.2023.030
Zdeněk Monhart

Internal medicine specialists, also known as general internal medicine specialists are specialist physicians trained to manage particularly complex or multisystem disease conditions that single-organ-disease specialists may not be trained to deal with. The management of multimorbidity, however, is often complex, and requires specific clinical skills and corresponding experience in appropriate diagnostic and therapeutic procedures. Multimorbidity is associated with a decline in many aspects of health and in consequence with an increase in hospital admissions, polypharmacy, and use of health care and social resouces. When prescribing medicine to patients with multimorbidity, all the risks and benefits, as well as possible interactions should be carefully considered. The prescription appropriateness can be assessed by validated tools like STOPP-START criteria. Beneficial part of good prescribing is deprescribing - planned and supervised process of dose reduction or withdrawal of medications that are no longer needed in the circumstances of the patient.

内科专家,也被称为普通内科专家,是指接受过培训的专科医生,能够处理单器官疾病专家可能无法处理的特别复杂或多系统的疾病。然而,多发性疾病的管理往往很复杂,需要特定的临床技能和适当的诊断和治疗程序的相应经验。多发病与健康的许多方面的下降有关,因此与入院人数、多药治疗、医疗保健和社会资源的使用增加有关。在给多发病患者开药时,应仔细考虑所有的风险和益处,以及可能的相互作用。处方的适当性可以通过STOP-START标准等经过验证的工具进行评估。良好处方的有益部分是取消描述——有计划和监督的减少剂量或停药过程,这些药物在患者的情况下不再需要。
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引用次数: 0
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