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Extracranial internal carotid artery aneurysm: Surgical approach to a rare entity. 颅外颈内动脉瘤:罕见病例的手术方法。
IF 1 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-13 DOI: 10.1177/17085381241290634
Didem Melis Oztas, Seckin Cobanoglu, Asli Cakir, Okan Kuguoglu, Emre Oteyaka, Murat Ugurlucan

Background: Extracranial internal carotid artery aneurysms are rare entities that arise within the carotid triangle. Although rare, they are clinically significant due to the risk of neurologic thromboembolic events, compression of cranial nerves and vasculature, rupture, and ischemia.

Objective: Surgery is the gold-standard treatment for symptomatic patients of all ages with extracranial internal carotid artery aneurysm.

Method: A 26-year-old female patient was admitted to our institution with complaints of left auricular pain, hoarseness, and uncontrollable hypertension. She had a pulsatile mass located at the left cervical region. After diagnosing the extracranial internal carotid artery aneurysm, it was decided that surgery was necessary to relieve the patient's discomfort and prevent possible complications from the aneurysm in the left carotid artery.

Result: In the operation, the aneurysmatic segment was resected and sent for histopathological evaluation. Saphenous vein graft was interposed as end to end anastomosis to the proximal and distal healthy segments of the internal carotid artery.

Conclusion: This case report highlights the surgical management of a 26-year-old female patient who presented to our institution with complaints of left auricular pain, hoarseness, uncontrolled hypertension, and a pulsatile mass localized at the left cervical region and diagnosed extracranial internal carotid artery aneurysm.

背景:颅外颈内动脉瘤是发生在颈动脉三角内的罕见实体。虽然罕见,但由于存在神经系统血栓栓塞事件、压迫颅神经和血管、破裂和缺血的风险,因此具有重要的临床意义:手术是治疗有症状的各年龄段颅外颈内动脉瘤患者的金标准:一名 26 岁的女性患者因主诉左耳疼痛、声音嘶哑和无法控制的高血压而入住我院。她的左颈部有一个搏动性肿块。在诊断出颅内颈内动脉瘤后,医生决定必须进行手术治疗,以缓解患者的不适症状,并防止左侧颈内动脉瘤可能引发的并发症:手术切除了动脉瘤部分,并送去进行组织病理学评估。结果:手术中,动脉瘤部分被切除,并送去进行组织病理学评估,无隐静脉移植作为端对端吻合器与颈内动脉的近端和远端健康部分相连:本病例报告重点介绍了一名 26 岁女性患者的手术治疗情况,该患者因主诉左耳疼痛、声音嘶哑、高血压未得到控制、左颈部局部有搏动性肿块而到我院就诊,诊断为颅外颈内动脉瘤。
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引用次数: 0
Comparing anticoagulant therapy alone, anticoagulant therapy in combination with catheter-directed thrombolysis, and anticoagulant therapy in combination with pharmacomechanical catheter-directed thrombolysis in the patients with optional inferior vena cava filter-related thrombosis: A single-center retrospective study. 在可选的下腔静脉滤器相关血栓形成患者中,比较单纯抗凝疗法、抗凝疗法与导管引导溶栓相结合,以及抗凝疗法与药物机械导管引导溶栓相结合:单中心回顾性研究
IF 1 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-12 DOI: 10.1177/17085381241289825
Zhaoyang Li, Zhicheng Duan, Huitang Yang, Meng Li, Yandong Cai, Zhan Jiang, Guoju Fan, Kaiqiang Wang, Bo Chen, Hongwei Zhang, Yankui Li
<p><strong>Objective: </strong>To analyze the treatment methods and efficacy of inferior vena cava filter thrombosis (IVCFT).</p><p><strong>Materials and methods: </strong>In this retrospective study, the clinical data for 47 patients with IVCFT who underwent sequential treatment at the Department of Vascular Surgery, Tianjin Medical University Second Hospital, from January 2020 to January 2023 were analyzed. Patients were divided into three groups according to the treatment method: anticoagulant therapy (AC group), anticoagulation plus catheter-directed thrombolysis (CDT group), and anticoagulation plus AngioJet thrombectomy plus catheter-directed thrombolysis (PCDT group). The evaluation criteria for efficacy mainly included preoperative and postoperative clinical symptoms (Villalta score), thrombus diameter, thrombus clearance rate, filter retrieval rate, filter retention time, and urokinase dosage.</p><p><strong>Results: </strong>This study included 47 patients, of whom 31 were males (65.9%) and 16 females (34.1%), with a mean age of 72.05 ± 8.32 years. An Aegisy filter was used in seven patients, whereas an Illicium filter was used in forty patients. There were a total of nineteen patients in the anticoagulation-only group, with complete dissolution of the intraluminal thrombus in five patients, a residual thrombus with a maximum diameter ≤1 cm in three patients, and a residual thrombus with a maximum diameter >1 cm in eleven patients. The Villalta score was 7.16 ± 0.6 before treatment and decreased to 3.79 ± 0.59 after treatment. The thrombus diameter decreased from an average of 1.46 ± 0.2 cm before treatment to an average of 0.85 ± 0.14 cm after treatment. The retrieval rate for the filters was 42.11% (8/19), with an average dwell time of 27.4 ± 1.3 days for the filters. The CDT group consisted of 17 patients. Among whom we observed, complete dissolution of the intraluminal thrombus was observed in six patients, residual thrombus with a maximum diameter ≤1 cm in nine patients, and residual thrombus with a maximum diameter >1 cm in two patients. The Villalta score decreased from 7.53 ± 0.83 before treatment to 2.06 ± 0.39 after treatment. The thrombus diameter also decreased from 1.46 ± 0.16 cm before treatment to 0.35 ± 0.11 cm after treatment. The retrieval rate of the filters was 88.24% (15/17), and the average filter indwelling time was 19.25 ± 4.5 days. The PCDT group consisted of 11 patients. We observed complete dissolution of the intraluminal thrombus in four patients, residual thrombus with a maximum diameter ≤1 cm in six patients, and residual thrombus with a maximum diameter >1 cm in one patient. The Villalta score decreased from 7.45 ± 0.76 before treatment to 2.09 ± 0.55 after treatment. The thrombus diameter decreased from 1.50 ± 0.21 cm before treatment to 0.33 ± 0.35 cm after treatment, and the rate of filter retrieval was 90.91% (10/11).</p><p><strong>Conclusion: </strong>The three treatments of anticoagulation therapy, CD
目的:分析下腔静脉滤器血栓形成的治疗方法和疗效:分析下腔静脉滤器血栓(IVCFT)的治疗方法和疗效:本回顾性研究分析了2020年1月至2023年1月在天津医科大学第二医院血管外科接受序贯治疗的47例IVCFT患者的临床资料。根据治疗方法将患者分为三组:抗凝治疗组(AC 组)、抗凝加导管引导溶栓治疗组(CDT 组)和抗凝加 AngioJet 取栓加导管引导溶栓治疗组(PCDT 组)。疗效评估标准主要包括术前和术后临床症状(Villalta评分)、血栓直径、血栓清除率、滤器取栓率、滤器保留时间和尿激酶用量:本研究共纳入 47 例患者,其中男性 31 例(65.9%),女性 16 例(34.1%),平均年龄(72.05±8.32)岁。七名患者使用了 Aegisy 过滤器,四十名患者使用了 Illicium 过滤器。单纯抗凝组共有 19 名患者,其中 5 名患者的腔内血栓完全溶解,3 名患者的残余血栓最大直径≤1 厘米,11 名患者的残余血栓最大直径大于 1 厘米。治疗前的 Villalta 评分为 7.16 ± 0.6,治疗后降至 3.79 ± 0.59。血栓直径从治疗前的平均 1.46 ± 0.2 厘米降至治疗后的平均 0.85 ± 0.14 厘米。滤器取回率为 42.11%(8/19),滤器平均停留时间为 27.4 ± 1.3 天。CDT 组有 17 名患者。我们观察到,其中 6 名患者的腔内血栓完全溶解,9 名患者的残余血栓最大直径≤1 厘米,2 名患者的残余血栓最大直径大于 1 厘米。Villalta 评分从治疗前的 7.53 ± 0.83 降至治疗后的 2.06 ± 0.39。血栓直径也从治疗前的 1.46 ± 0.16 厘米降至治疗后的 0.35 ± 0.11 厘米。滤器取回率为 88.24%(15/17),滤器平均留置时间为 19.25 ± 4.5 天。PCDT 组有 11 名患者。我们观察到 4 名患者的腔内血栓完全溶解,6 名患者的残余血栓最大直径≤1 厘米,1 名患者的残余血栓最大直径大于 1 厘米。Villalta 评分从治疗前的 7.45 ± 0.76 降至治疗后的 2.09 ± 0.55。血栓直径从治疗前的 1.50 ± 0.21 厘米降至治疗后的 0.33 ± 0.35 厘米,滤器取出率为 90.91%(10/11):结论:抗凝治疗、CDT和PCDT三种治疗方法对IVCFT患者术前和术后溶栓及症状改善均有意义。CDT 和 PCDT 的应用优于抗凝疗法,而 CDT 组和 PCDT 组之间无明显差异。抗凝治疗组的滤器取回率最低,CDT 组和 PCDT 组之间无明显差异。
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引用次数: 0
Comparative outcomes of surgical and conservative management in carotid artery dissection. 颈动脉夹层手术与保守治疗的疗效比较。
IF 1 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-05 DOI: 10.1177/17085381241289815
Yuyao Feng, Zhan Zhu, Jiang Shao, Kang Li, Yiyun Xie, Lizhi Xie, Yuru Wang, Lin Wang, Huanyu Dai, Zhichao Lai, Bao Liu

Objectives: Carotid artery dissection (CAD) is a significant cause of strokes in young individuals, leading to severe complications and socioeconomic burdens. Despite antithrombotic therapy being the primary management strategy, optimal treatment for patients with recurrent or worsening symptoms remains undefined. This study aims to describe the characteristics and evaluate the outcomes of conservative versus surgical management in CAD patients.

Methods: A total of 23 patients presenting with CAD from November 2014 to December 2021 were reviewed retrospectively. Patient demographics, vascular risk factors, symptoms, imaging results, treatment details, and follow-up information were collected and analyzed. Propensity score matching (PSM) was utilized to enhance comparability.

Results: The mean age of the patients was 46.4 ± 9.4 years, with a median follow-up of 12 (range 3-90) months. Of the 23 patients reviewed, seven underwent endovascular treatment or open surgery due to unresponsiveness to conservative therapy, while 16 received conservative management. All patients showed regression of symptoms. Surgical patients showed a significant improvement with a 100% patency rate during the follow-up. PS matching adjusted for baseline differences, yielding comparable groups for analysis. No significant difference between treatment approaches was observed in stroke recurrence rates, although surgical intervention showed promising outcomes in symptom resolution and stroke prevention.

Conclusion: Both conservative and surgical management of CAD can lead to favorable outcomes. While conservative therapy remains the initial approach and proves effective, surgery appears beneficial and safe in certain cases unresponsive to conservative treatment. Further investigation through larger prospective and randomized trials is necessary to establish its safety and efficacy.

目的:颈动脉夹层(CAD)是年轻人中风的一个重要原因,会导致严重的并发症和社会经济负担。尽管抗血栓治疗是主要的治疗策略,但对于症状复发或恶化的患者,最佳治疗方法仍未确定。本研究旨在描述 CAD 患者保守治疗与手术治疗的特点,并评估其疗效:回顾性研究了 2014 年 11 月至 2021 年 12 月期间的 23 例 CAD 患者。收集并分析了患者的人口统计学特征、血管风险因素、症状、成像结果、治疗细节和随访信息。为增强可比性,采用了倾向得分匹配法(PSM):患者的平均年龄为 46.4 ± 9.4 岁,中位随访时间为 12 个月(3-90 个月)。在接受复查的 23 名患者中,7 人因保守治疗无效而接受了血管内治疗或开放手术,16 人接受了保守治疗。所有患者的症状都有所缓解。手术患者的症状明显改善,随访期间通畅率达到 100%。PS配对调整了基线差异,得出了具有可比性的分析组。虽然手术治疗在缓解症状和预防中风方面效果良好,但不同治疗方法在中风复发率方面无明显差异:结论:CAD 的保守治疗和手术治疗都能带来良好的疗效。结论:保守治疗和手术治疗都能带来良好的疗效。虽然保守治疗仍是最初的方法并证明有效,但在某些对保守治疗无反应的病例中,手术治疗似乎是有益和安全的。有必要通过更大规模的前瞻性随机试验进行进一步研究,以确定其安全性和有效性。
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引用次数: 0
Embolization of a ruptured cystic artery pseudoaneurysm by percutaneous injection. 经皮注射栓塞破裂的囊性动脉假动脉瘤。
IF 1 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-04 DOI: 10.1177/17085381241289821
Fatih Hakan Tufanoğlu, Behiç Akyüz

Background: Pseudoaneurysm of the cystic artery is very rare. It usually presents with rupture and hemorrhagic shock, which may be life-threatening. Ultrasonography and contrast-enhanced tomography can be used for the diagnosis. The mainstay of treatment for this disease is cholecystectomy.

Objective: Here we present an 86-year-old man with known diabetes and Alzheimer's disease whose pseudoaneurysm was treated with percutaneous thrombin injection and highlight the technical aspect of the procedure.

Method: With ultrasonography guidance, a 21-gauge Chiba needle was passed through the liver and advanced into the pseudoaneurysm sac. A controlled, slow injection of 0.5-cc thrombin into the sac was performed with instant occlusion. Doppler imaging performed immediately following the procedure revealed that the pseudoaneurysm was not filled.

Conclusion: Pseudoaneurysm of the gallbladder is extremely rare, and its diagnosis is difficult. If the condition is not treated right away, it can quickly become life-threatening. The majority of the pseudoaneurysms have already ruptured, and the patients are clinically septic, making surgery dangerous. Also, the use of contrast media in these patients may increase the risk of nephropathy, which is not an issue with percutaneous injection. Due to the obvious risk of rupture and bleeding, we propose injecting pseudoaneurysms only if they have a visible wall.

Result: Percutaneous injection of the gallbladder pseudoaneurysms can be an option when treating gallbladder pseudoaneurysms. More research on long-term success rates is required.

背景:囊性动脉假性动脉瘤非常罕见。它通常表现为破裂和失血性休克,可能危及生命。超声波和造影剂增强断层扫描可用于诊断。目的:我们在此介绍一名患有糖尿病和阿尔茨海默病的 86 岁男性,他的假性动脉瘤是通过经皮凝血酶注射治疗的,并重点介绍了手术的技术方面:在超声引导下,将 21 号千叶针穿过肝脏,推进假性动脉瘤囊。向囊内缓慢注射 0.5 毫升凝血酶,并在瞬间闭塞。术后立即进行的多普勒成像显示,假性动脉瘤未被填塞:结论:胆囊假性动脉瘤极为罕见,而且诊断困难。如果不及时治疗,很快就会危及生命。大多数假性动脉瘤已经破裂,患者临床上处于败血症状态,因此手术非常危险。此外,对这些患者使用造影剂可能会增加肾病的风险,而经皮注射则不会出现这种问题。由于假性动脉瘤有明显的破裂和出血风险,我们建议只有在假性动脉瘤有明显的瘤壁时才对其进行注射:结果:经皮注射胆囊假性动脉瘤是治疗胆囊假性动脉瘤的一种选择。需要对长期成功率进行更多研究。
{"title":"Embolization of a ruptured cystic artery pseudoaneurysm by percutaneous injection.","authors":"Fatih Hakan Tufanoğlu, Behiç Akyüz","doi":"10.1177/17085381241289821","DOIUrl":"https://doi.org/10.1177/17085381241289821","url":null,"abstract":"<p><strong>Background: </strong>Pseudoaneurysm of the cystic artery is very rare. It usually presents with rupture and hemorrhagic shock, which may be life-threatening. Ultrasonography and contrast-enhanced tomography can be used for the diagnosis. The mainstay of treatment for this disease is cholecystectomy.</p><p><strong>Objective: </strong>Here we present an 86-year-old man with known diabetes and Alzheimer's disease whose pseudoaneurysm was treated with percutaneous thrombin injection and highlight the technical aspect of the procedure.</p><p><strong>Method: </strong>With ultrasonography guidance, a 21-gauge Chiba needle was passed through the liver and advanced into the pseudoaneurysm sac. A controlled, slow injection of 0.5-cc thrombin into the sac was performed with instant occlusion. Doppler imaging performed immediately following the procedure revealed that the pseudoaneurysm was not filled.</p><p><strong>Conclusion: </strong>Pseudoaneurysm of the gallbladder is extremely rare, and its diagnosis is difficult. If the condition is not treated right away, it can quickly become life-threatening. The majority of the pseudoaneurysms have already ruptured, and the patients are clinically septic, making surgery dangerous. Also, the use of contrast media in these patients may increase the risk of nephropathy, which is not an issue with percutaneous injection. Due to the obvious risk of rupture and bleeding, we propose injecting pseudoaneurysms only if they have a visible wall.</p><p><strong>Result: </strong>Percutaneous injection of the gallbladder pseudoaneurysms can be an option when treating gallbladder pseudoaneurysms. More research on long-term success rates is required.</p>","PeriodicalId":23549,"journal":{"name":"Vascular","volume":" ","pages":"17085381241289821"},"PeriodicalIF":1.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142376106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physician-modified funnel-shaped covered stent for selective false lumen exclusion in chronic type B aortic dissection. 用于慢性 B 型主动脉夹层选择性假腔排除的医生改良型漏斗状覆盖支架。
IF 1 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-04 DOI: 10.1177/17085381241289811
Lorenzo Torri, Petroula Nana, Giuseppe Panuccio, José Ignacio Torrealba, Daour Yousef El Sarhan, Tilo Kölbel

Purpose: To describe the technique of off-centering a balloon-expandable covered stent for selective occlusion of a distal entry tear (ET) in a patient, conservatively treated for chronic type B aortic dissection (cTBAD), presenting FL expansion.

Technique: A 63-year-old male, with conservatively managed cTBAD, presented at follow-up with FL partial thrombosis and expansion (thoracic aorta FL from 21 mm to 27 mm and abdominal aorta FL from 11 mm to 15 mm in 6 months). No proximal ET was identifiable. Distal FL perfusion was caused by an ET in the abdominal aorta feeding a 2 mm accessory renal artery (ARA). As the aortic diameter was below the threshold for endovascular repair, a selective occlusion of the distal ET and ARA was planned. A balloon-expandable covered stent was modified by off-centering the covered stent proximally and resulting in a funnel-shape occluder after deployment across the ET into the ARA. To prevent type Ic endoleak due to possible FL expansion caused by an intra-operatively detected phrenic artery (PA), coils were deployed into the lumen of the modified stent and the ARA. The pre-discharge computed tomography angiography showed exclusion of both the ARA and ET and a type 2 endoleak from the PA.

Conclusion: A balloon-expandable covered stent can be modified by off-centering the covered stent resulting in a funnel shape to adapt to different diameter requirements.

目的:描述在一名接受保守治疗的慢性 B 型主动脉夹层(cTBAD)患者中,采用偏离中心的球囊扩张覆盖支架选择性封堵远端入口撕裂(ET)的技术:一名 63 岁的男性,因慢性 B 型主动脉夹层(cTBAD)接受保守治疗,在随访时出现 FL 部分血栓形成和扩张(胸主动脉 FL 在 6 个月内从 21 mm 增至 27 mm,腹主动脉 FL 在 6 个月内从 11 mm 增至 15 mm)。未发现近端 ET。FL远端灌注是由腹主动脉中的ET造成的,ET为2毫米的肾脏附属动脉(ARA)供血。由于主动脉直径低于血管内修复的阈值,因此计划对远端 ET 和 ARA 进行选择性闭塞。对球囊扩张覆盖支架进行了改良,将覆盖支架向近端偏离中心,使其在穿过 ET 进入 ARA 后形成漏斗状闭塞。为防止术中检测到的膈动脉(PA)可能导致的FL扩张造成Ic型内漏,在改良支架和ARA的管腔内部署了线圈。出院前的计算机断层扫描血管造影显示,ARA和ET均被排除,PA出现了2型内漏:结论:球囊扩张型覆膜支架可通过偏离覆膜支架的中心形成漏斗状来进行改造,以适应不同直径的要求。
{"title":"Physician-modified funnel-shaped covered stent for selective false lumen exclusion in chronic type B aortic dissection.","authors":"Lorenzo Torri, Petroula Nana, Giuseppe Panuccio, José Ignacio Torrealba, Daour Yousef El Sarhan, Tilo Kölbel","doi":"10.1177/17085381241289811","DOIUrl":"https://doi.org/10.1177/17085381241289811","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the technique of off-centering a balloon-expandable covered stent for selective occlusion of a distal entry tear (ET) in a patient, conservatively treated for chronic type B aortic dissection (cTBAD), presenting FL expansion.</p><p><strong>Technique: </strong>A 63-year-old male, with conservatively managed cTBAD, presented at follow-up with FL partial thrombosis and expansion (thoracic aorta FL from 21 mm to 27 mm and abdominal aorta FL from 11 mm to 15 mm in 6 months). No proximal ET was identifiable. Distal FL perfusion was caused by an ET in the abdominal aorta feeding a 2 mm accessory renal artery (ARA). As the aortic diameter was below the threshold for endovascular repair, a selective occlusion of the distal ET and ARA was planned. A balloon-expandable covered stent was modified by off-centering the covered stent proximally and resulting in a funnel-shape occluder after deployment across the ET into the ARA. To prevent type Ic endoleak due to possible FL expansion caused by an intra-operatively detected phrenic artery (PA), coils were deployed into the lumen of the modified stent and the ARA. The pre-discharge computed tomography angiography showed exclusion of both the ARA and ET and a type 2 endoleak from the PA.</p><p><strong>Conclusion: </strong>A balloon-expandable covered stent can be modified by off-centering the covered stent resulting in a funnel shape to adapt to different diameter requirements.</p>","PeriodicalId":23549,"journal":{"name":"Vascular","volume":" ","pages":"17085381241289811"},"PeriodicalIF":1.0,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A systematic review and meta-analysis of outcomes associated with development of surgical site infection after lower-limb revascularization surgery. 下肢血管重建手术后手术部位感染相关结果的系统回顾和荟萃分析。
IF 1 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-03 DOI: 10.1177/17085381241290039
Aidan M Kirkham, Jasmine Candeliere, Sudhir K Nagpal, Henry T Stelfox, Dalibor Kubelik, George Hajjar, Derek R MacFadden, Daniel I McIsaac, Derek J Roberts
<p><strong>Objectives: </strong>Although surgical site infection (SSI) is a commonly used quality metric after lower-limb revascularization surgery, outcomes associated with development of this complication are poorly characterized. We conducted a systematic review and meta-analysis of studies reporting associations between development of an SSI after these procedures and clinical outcomes and healthcare resource use.</p><p><strong>Methods: </strong>We searched MEDLINE, Embase, CENTRAL, and Evidence-Based Medicine Reviews (inception to April 4th, 2023) for studies examining adjusted associations between development of an SSI after lower-limb revascularization surgery and clinical outcomes and healthcare resource use. Two investigators independently screened abstracts and full-text citations, extracted data, and assessed risk of bias. Data were pooled using random-effects models. Heterogeneity was assessed using I<sup>2</sup> statistics. GRADE was used to assess estimate certainty.</p><p><strong>Results: </strong>Among 6671 citations identified, we included 11 studies (n = 61,628 total patients) that reported adjusted-associations between development of an SSI and 13 different outcomes. Developing an SSI was associated with an increased adjusted-risk of hospital readmission (pooled adjusted-risk ratio (aRR) = 3.55; 95% CI (confidence interval) = 1.40-8.97; n = 4 studies; n = 13,532 patients; I<sup>2</sup> = 99.0%; moderate certainty), bypass graft thrombosis within 30-days (pooled aRR = 2.09; 95% CI = 1.41-3.09; n = 2 studies; n = 23,240 patients; I<sup>2</sup> = 51.1%; low certainty), reoperation (pooled aRR = 2.69; 95% CI = 2.67-2.72; n = 2 studies; n = 23,240 patients; I<sup>2</sup> = 0.0%; moderate certainty), bleeding requiring a transfusion or secondary procedure (aRR = 1.40; 95% CI = 1.26-1.55; n = 1 study; n = 10,910 patients; low certainty), myocardial infarction or stroke (aRR = 1.21; 95% CI = 1.02-1.43; n = 1 study; n = 10,910 patients; low certainty), and major (i.e., above-ankle) amputation (pooled aRR = 1.93; 95% CI = 1.26-2.95; n = 4 studies; n = 32,859 patients; I<sup>2</sup> = 83.0; low certainty). Development of an SSI >30-days after the index operation (aRR = 2.20; 95% CI = 1.16-4.17; n = 3 studies; n = 21,949 patients; low certainty) and prosthetic graft infection (aRR = 6.72; 95% CI = 3.21-12.70; n = 1 study; n = 272 patients; low certainty) were both associated with an increased adjusted-risk of major amputation. Prosthetic graft infection was also associated with an increased adjusted-risk of mortality >30-days after the index procedure (aRR = 6.40; 95% CI = 3.32-12.36; n = 1 study; n = 272 patients; low certainty).</p><p><strong>Conclusions: </strong>This systematic review and meta-analysis suggests that development of an SSI after lower-limb revascularization surgery significantly increases patient morbidity and healthcare resource use. SSI is therefore a valuable quality metric after these surgeries. However, current esti
目的:虽然手术部位感染(SSI)是下肢血管重建手术后常用的质量指标,但与这种并发症相关的结果却很少被提及。我们对报告这些手术后发生 SSI 与临床结果和医疗资源使用之间关系的研究进行了系统回顾和荟萃分析:我们检索了 MEDLINE、Embase、CENTRAL 和循证医学综述(起始时间至 2023 年 4 月 4 日),以研究下肢血管重建手术后发生 SSI 与临床结果和医疗资源使用之间的调整关系。两名研究人员独立筛选摘要和全文引文、提取数据并评估偏倚风险。采用随机效应模型对数据进行汇总。使用 I2 统计量评估异质性。采用 GRADE 评估估计确定性:在确定的 6671 篇引文中,我们纳入了 11 项研究(n = 61628 名患者),这些研究报告了 SSI 的发生与 13 种不同结果之间的调整关联。发生 SSI 与再入院的调整风险增加(汇总调整风险比 (aRR) = 3.55;95% CI(置信区间)= 1.40-8.97;n = 4 项研究;n = 13,532 名患者;I2 = 99.0%;中等确定性)、30 天内旁路移植血栓形成(汇总 aRR = 2.09;95% CI = 1.41-3.09;n = 2 项研究;n = 23,240 名患者;I2 = 51.1%;低度确定性)、再次手术(汇总 aRR = 2.69;95% CI = 2.67-2.72;n = 2 项研究;n = 23 240 例患者;I2 = 0.0%;中度确定性)、需要输血或二次手术的出血(aRR = 1.40; 95% CI = 1.26-1.55; n = 1 项研究; n = 10,910 名患者; 低度确定性)、心肌梗死或中风(aRR = 1.21; 95% CI = 1.02-1.43; n = 1 项研究; n = 10,910 名患者; 低度确定性)和重大(即:踝关节以上)截肢(汇总 aRR = 1.93;95% CI = 1.26-2.95;n = 4 项研究;n = 32,859 例患者;I2 = 83.0;低确定性)。指数手术后 >30 天发生 SSI(aRR = 2.20;95% CI = 1.16-4.17;n = 3 项研究;n = 21,949 名患者;低确定性)和假体移植物感染(aRR = 6.72;95% CI = 3.21-12.70;n = 1 项研究;n = 272 名患者;低确定性)均与大截肢的调整后风险增加有关。假体移植物感染也与指数手术后30天以上的调整后死亡风险增加有关(aRR = 6.40; 95% CI = 3.32-12.36; n = 1项研究; n = 272例患者; 低确定性):本系统综述和荟萃分析表明,下肢血管重建手术后出现 SSI 会显著增加患者的发病率和医疗资源的使用。因此,SSI 是衡量此类手术质量的重要指标。然而,目前的估计是基于不同的、中低度确定性的证据,应该由大型、多中心、队列研究来证实。
{"title":"A systematic review and meta-analysis of outcomes associated with development of surgical site infection after lower-limb revascularization surgery.","authors":"Aidan M Kirkham, Jasmine Candeliere, Sudhir K Nagpal, Henry T Stelfox, Dalibor Kubelik, George Hajjar, Derek R MacFadden, Daniel I McIsaac, Derek J Roberts","doi":"10.1177/17085381241290039","DOIUrl":"https://doi.org/10.1177/17085381241290039","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;Although surgical site infection (SSI) is a commonly used quality metric after lower-limb revascularization surgery, outcomes associated with development of this complication are poorly characterized. We conducted a systematic review and meta-analysis of studies reporting associations between development of an SSI after these procedures and clinical outcomes and healthcare resource use.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We searched MEDLINE, Embase, CENTRAL, and Evidence-Based Medicine Reviews (inception to April 4th, 2023) for studies examining adjusted associations between development of an SSI after lower-limb revascularization surgery and clinical outcomes and healthcare resource use. Two investigators independently screened abstracts and full-text citations, extracted data, and assessed risk of bias. Data were pooled using random-effects models. Heterogeneity was assessed using I&lt;sup&gt;2&lt;/sup&gt; statistics. GRADE was used to assess estimate certainty.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Among 6671 citations identified, we included 11 studies (n = 61,628 total patients) that reported adjusted-associations between development of an SSI and 13 different outcomes. Developing an SSI was associated with an increased adjusted-risk of hospital readmission (pooled adjusted-risk ratio (aRR) = 3.55; 95% CI (confidence interval) = 1.40-8.97; n = 4 studies; n = 13,532 patients; I&lt;sup&gt;2&lt;/sup&gt; = 99.0%; moderate certainty), bypass graft thrombosis within 30-days (pooled aRR = 2.09; 95% CI = 1.41-3.09; n = 2 studies; n = 23,240 patients; I&lt;sup&gt;2&lt;/sup&gt; = 51.1%; low certainty), reoperation (pooled aRR = 2.69; 95% CI = 2.67-2.72; n = 2 studies; n = 23,240 patients; I&lt;sup&gt;2&lt;/sup&gt; = 0.0%; moderate certainty), bleeding requiring a transfusion or secondary procedure (aRR = 1.40; 95% CI = 1.26-1.55; n = 1 study; n = 10,910 patients; low certainty), myocardial infarction or stroke (aRR = 1.21; 95% CI = 1.02-1.43; n = 1 study; n = 10,910 patients; low certainty), and major (i.e., above-ankle) amputation (pooled aRR = 1.93; 95% CI = 1.26-2.95; n = 4 studies; n = 32,859 patients; I&lt;sup&gt;2&lt;/sup&gt; = 83.0; low certainty). Development of an SSI &gt;30-days after the index operation (aRR = 2.20; 95% CI = 1.16-4.17; n = 3 studies; n = 21,949 patients; low certainty) and prosthetic graft infection (aRR = 6.72; 95% CI = 3.21-12.70; n = 1 study; n = 272 patients; low certainty) were both associated with an increased adjusted-risk of major amputation. Prosthetic graft infection was also associated with an increased adjusted-risk of mortality &gt;30-days after the index procedure (aRR = 6.40; 95% CI = 3.32-12.36; n = 1 study; n = 272 patients; low certainty).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This systematic review and meta-analysis suggests that development of an SSI after lower-limb revascularization surgery significantly increases patient morbidity and healthcare resource use. SSI is therefore a valuable quality metric after these surgeries. However, current esti","PeriodicalId":23549,"journal":{"name":"Vascular","volume":" ","pages":"17085381241290039"},"PeriodicalIF":1.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Does complete blood count have a role in the prediction of deep vein thrombosis? 全血细胞计数对预测深静脉血栓有作用吗?
IF 1 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-01 Epub Date: 2023-05-08 DOI: 10.1177/17085381231175260
Osman Fehmi Beyazal

Methods: It was planned as a retrospective case-control study in which 1,527 patients between January 2022 and September 2022 were evaluated. After the eligibility criteria, systematic sampling was performed and analyzed in the case group (103) and the control group (179) patients. The predictive significance of Hb, NLR, PLR, MPV, PLT, MPV/PLT, monocytes, lymphocytes, eosinophils, RDW, LMR, and PDW parameters for the development of DVT was investigated. Then, logistic regression analysis was performed with these parameters to analyze the predictive value. The cutoff point was determined by performing ROC analysis for the statistically significant parameters.

Results: Neutrophil, RDW, PDW, NLR, and MPV/platelet values were statistically higher in the DVT group than the control group. Lymphocyte, PLT, and LMR values were statistically lower in the DVT group than the control group. There was no statistical difference between the two groups in terms of neutrophils, monocytes, eosinophils, Hb, MPV, and PLR values. RDW and PDW values were statistically significant for DVT prediction (p < 0.001, OR = 1.183 and p < 0.001, OR = 1.304, respectively). According to ROC analysis, 45.5 fL for RDW and 14.3 fL for PDW were determined as the cutoff points for DVT prediction.

Conclusion: We found RDW and PDW to be significant in terms of DVT prediction in our study. We found the NLR and MPV/PLT to be higher in the DVT group, and the LMR to be lower in the DVT group, but we found that there was no statistically significant predictive value. CBC can be used as an inexpensive and easily accessible test that has predictive significance for DVT. In addition, these findings need to be supported by prospective studies in the future.

研究方法该研究计划作为一项回顾性病例对照研究,对 2022 年 1 月至 2022 年 9 月期间的 1 527 名患者进行评估。在符合资格标准后,对病例组(103 例)和对照组(179 例)患者进行系统抽样和分析。研究了 Hb、NLR、PLR、MPV、PLT、MPV/PLT、单核细胞、淋巴细胞、嗜酸性粒细胞、RDW、LMR 和 PDW 参数对深静脉血栓形成的预测意义。然后,利用这些参数进行逻辑回归分析,以分析其预测价值。通过对具有统计学意义的参数进行ROC分析,确定了临界点:结果:据统计,DVT 组的中性粒细胞、RDW、PDW、NLR 和 MPV/platelet 值均高于对照组。据统计,深静脉血栓组的淋巴细胞、PLT 和 LMR 值低于对照组。两组在中性粒细胞、单核细胞、嗜酸性粒细胞、血红蛋白、MPV 和 PLR 值方面没有统计学差异。RDW 和 PDW 值对深静脉血栓预测具有显著的统计学意义(分别为 P < 0.001,OR = 1.183 和 P < 0.001,OR = 1.304)。根据 ROC 分析,RDW 为 45.5 fL,PDW 为 14.3 fL,被确定为预测深静脉血栓的临界点:结论:在我们的研究中,我们发现 RDW 和 PDW 对预测深静脉血栓具有重要意义。我们发现 NLR 和 MPV/PLT 在深静脉血栓组较高,而 LMR 在深静脉血栓组较低,但我们发现它们在统计学上没有显著的预测价值。CBC可作为一种廉价且容易获得的检测方法,对深静脉血栓有预测意义。此外,这些发现还需要未来的前瞻性研究来支持。
{"title":"Does complete blood count have a role in the prediction of deep vein thrombosis?","authors":"Osman Fehmi Beyazal","doi":"10.1177/17085381231175260","DOIUrl":"10.1177/17085381231175260","url":null,"abstract":"<p><strong>Methods: </strong>It was planned as a retrospective case-control study in which 1,527 patients between January 2022 and September 2022 were evaluated. After the eligibility criteria, systematic sampling was performed and analyzed in the case group (103) and the control group (179) patients. The predictive significance of Hb, NLR, PLR, MPV, PLT, MPV/PLT, monocytes, lymphocytes, eosinophils, RDW, LMR, and PDW parameters for the development of DVT was investigated. Then, logistic regression analysis was performed with these parameters to analyze the predictive value. The cutoff point was determined by performing ROC analysis for the statistically significant parameters.</p><p><strong>Results: </strong>Neutrophil, RDW, PDW, NLR, and MPV/platelet values were statistically higher in the DVT group than the control group. Lymphocyte, PLT, and LMR values were statistically lower in the DVT group than the control group. There was no statistical difference between the two groups in terms of neutrophils, monocytes, eosinophils, Hb, MPV, and PLR values. RDW and PDW values were statistically significant for DVT prediction (<i>p</i> < 0.001, OR = 1.183 and <i>p</i> < 0.001, OR = 1.304, respectively). According to ROC analysis, 45.5 fL for RDW and 14.3 fL for PDW were determined as the cutoff points for DVT prediction.</p><p><strong>Conclusion: </strong>We found RDW and PDW to be significant in terms of DVT prediction in our study. We found the NLR and MPV/PLT to be higher in the DVT group, and the LMR to be lower in the DVT group, but we found that there was no statistically significant predictive value. CBC can be used as an inexpensive and easily accessible test that has predictive significance for DVT. In addition, these findings need to be supported by prospective studies in the future.</p>","PeriodicalId":23549,"journal":{"name":"Vascular","volume":" ","pages":"1107-1115"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9424652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary aortoenteric fistula after intravesical instillation of Bacillus Calmette-Guérin for bladder cancer. 膀胱癌膀胱内注射卡介苗后的原发性肠主动脉瘘。
IF 1 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-01 Epub Date: 2023-05-06 DOI: 10.1177/17085381231174923
Javier Fernández Lorenzo, Irene María López Arquillo, Jorge Vidal Rey

Objective: Primary aortoenteric fistulas (PAEFs) are a rare entity with high morbidity, and their relationship with Bacillus Instillation of Calmette-Guérin is anecdotal.

Methods/results: We present a 68-year-old male with a primary aortoenteric fistula after instillation of Bacillus Calmette-Guérin (BCG) for a non-muscle-invasive bladder cancer. Diagnosis was made by CT angiography, subsequently confirmed by intraoperative findings and results of anatomopathological studies of aortic wall samples. We performed an in-situ reconstruction with a silver prosthesis impregnated in rifampicin with satisfactory evolution at one year.

Conclusions: Primary aortoenteric fistula is an extremely rare complication, and although its relationship with intravesical BCG therapy is anecdotal, it should be considered in patients with gastrointestinal bleeding who have previously undergone this treatment. Its diagnosis requires clinical suspicion, and its treatment should be carried out without delay. Long-term targeted anti-biotherapeutic treatment is a fundamental pillar for its management. Reconstruction with an antibiotic-impregnated silver prosthesis is a valid option in cases of controlled infection.

目的:原发性肠主动脉瘘(PAEFs)是一种发病率很高的罕见疾病,其与卡介苗芽孢杆菌灌注的关系只是传闻:我们为您介绍一名因非肌层浸润性膀胱癌注射卡介苗(BCG)后出现原发性肠主动脉瘘的 68 岁男性患者。诊断是通过 CT 血管造影做出的,随后通过术中发现和主动脉壁样本的解剖病理学研究结果得到证实。我们用浸泡在利福平中的银假体进行了原位重建,一年后效果令人满意:原发性肠主动脉瘘是一种极为罕见的并发症,虽然它与膀胱内卡介苗治疗的关系只是传闻,但曾接受过这种治疗的消化道出血患者应考虑到这一点。其诊断需要临床怀疑,并且应立即进行治疗。长期有针对性的抗生素治疗是治疗的基本支柱。在感染得到控制的情况下,使用抗生素浸渍的银假体进行重建是一种有效的选择。
{"title":"Primary aortoenteric fistula after intravesical instillation of Bacillus Calmette-Guérin for bladder cancer.","authors":"Javier Fernández Lorenzo, Irene María López Arquillo, Jorge Vidal Rey","doi":"10.1177/17085381231174923","DOIUrl":"10.1177/17085381231174923","url":null,"abstract":"<p><strong>Objective: </strong>Primary aortoenteric fistulas (PAEFs) are a rare entity with high morbidity, and their relationship with Bacillus Instillation of Calmette-Guérin is anecdotal.</p><p><strong>Methods/results: </strong>We present a 68-year-old male with a primary aortoenteric fistula after instillation of Bacillus Calmette-Guérin (BCG) for a non-muscle-invasive bladder cancer. Diagnosis was made by CT angiography, subsequently confirmed by intraoperative findings and results of anatomopathological studies of aortic wall samples. We performed an <i>in-situ</i> reconstruction with a silver prosthesis impregnated in rifampicin with satisfactory evolution at one year.</p><p><strong>Conclusions: </strong>Primary aortoenteric fistula is an extremely rare complication, and although its relationship with intravesical BCG therapy is anecdotal, it should be considered in patients with gastrointestinal bleeding who have previously undergone this treatment. Its diagnosis requires clinical suspicion, and its treatment should be carried out without delay. Long-term targeted anti-biotherapeutic treatment is a fundamental pillar for its management. Reconstruction with an antibiotic-impregnated silver prosthesis is a valid option in cases of controlled infection.</p>","PeriodicalId":23549,"journal":{"name":"Vascular","volume":" ","pages":"952-956"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9767847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endovascular treatment of re-stenotic iliac artery stents with drug-eluting balloons. 使用药物洗脱球囊对再次狭窄的髂动脉支架进行血管内治疗。
IF 1 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-01 Epub Date: 2023-07-26 DOI: 10.1177/17085381231192731
Halil Berkan Özpak, Cihan Aydın

Aim: To evaluate the results of revascularization of stenotic iliac stents using drug-eluting balloons (DEBs).

Material and methods: Seventy-four patients with various levels of iliac stent restenosis were enrolled to study. All restenotic stents were treated using paclitaxel-coated balloons.

Results: Through a follow-up median period of 24 months (4-24 months), there were no in-stent re-restenosis in 55 patients (74.3%) and there was one in class 1 (1.4%), four in class 2 (5.4%), and fourteen in class 3 (18.9%).

Conclusion: We conclude that; DEBs can be used for restenotic iliac artery stents for some Type C and D lesions, in addition to Types A and B with satisfacting results.

目的:评估使用药物洗脱球囊(DEB)对狭窄的髂骨支架进行血管再通的效果:74例不同程度的髂骨支架再狭窄患者被纳入研究。所有再狭窄支架均使用紫杉醇涂层球囊进行治疗:中位随访期为 24 个月(4-24 个月),55 例患者(74.3%)未发生支架内再狭窄,1 级 1 例(1.4%),2 级 4 例(5.4%),3 级 14 例(18.9%):我们得出的结论是:除 A 型和 B 型病变外,DEB 还可用于某些 C 型和 D 型病变的髂动脉支架再狭窄,效果令人满意。
{"title":"Endovascular treatment of re-stenotic iliac artery stents with drug-eluting balloons.","authors":"Halil Berkan Özpak, Cihan Aydın","doi":"10.1177/17085381231192731","DOIUrl":"10.1177/17085381231192731","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the results of revascularization of stenotic iliac stents using drug-eluting balloons (DEBs).</p><p><strong>Material and methods: </strong>Seventy-four patients with various levels of iliac stent restenosis were enrolled to study. All restenotic stents were treated using paclitaxel-coated balloons.</p><p><strong>Results: </strong>Through a follow-up median period of 24 months (4-24 months), there were no in-stent re-restenosis in 55 patients (74.3%) and there was one in class 1 (1.4%), four in class 2 (5.4%), and fourteen in class 3 (18.9%).</p><p><strong>Conclusion: </strong>We conclude that; DEBs can be used for restenotic iliac artery stents for some Type C and D lesions, in addition to Types A and B with satisfacting results.</p>","PeriodicalId":23549,"journal":{"name":"Vascular","volume":" ","pages":"991-996"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psoas muscle analysis as a surrogate marker of sarcopenia and frailty: A multicenter analysis of predictive capacities over short- and long-term outcomes after abdominal aortic aneurysm repair. 腰肌分析作为肌肉疏松症和虚弱的替代标记物:腹主动脉瘤修补术后短期和长期疗效预测能力的多中心分析。
IF 1 4区 医学 Q4 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-10-01 Epub Date: 2023-08-01 DOI: 10.1177/17085381231193453
Rocío Vázquez Pérez, Francisco Álvarez Marcos, Cristina Tello Díaz, Sergi Bellmunt Montoya, Rafael Fernández-Samos Gutiérrez, Daniel Gil Sala

Objectives: Several predictive models exist for estimating the postoperative risks of abdominal aortic aneurysm (AAA) repair, although no particular tool has seen widespread use. We present the results of a multicenter, historic cohort study comparing the predictive capacity of the psoas muscle area (PMA), radiodensity (PMD), and lean muscle area (LMA) as surrogate markers of sarcopenia, over short- and long-term outcomes after AAA repair, compared to the mFI-5 and American Society of Anesthesiologists (ASA) scales.

Methods: Retrospective review was conducted of all consecutive AAA elective repair cases (open or endovascular) in three tertiary-care centers from 2014 to 2019. Cross-sectional PMA, PMD, and LMA at the mid-body of the L3 vertebra were measured by two independent operators in the preoperative computed tomography. Receiver operating characteristic (ROC) curves were used to determine optimal cutoff values. Bivariate analysis, logistic regression, and Cox's proportional hazards models were built to examine the relationship between baseline variables and postoperative mortality, long-term mortality, and complications.

Results: 596 patients were included (mean age 72.7 ± 8 years, 95.1% male, 66.9% EVAR). Perioperative mortality was 2.3% (EVAR 1.2% vs open repair 4.6%, p = .015), and no independent predictors could be identified in the multivariate analysis. Conversely, an age over 74 years old (OR 1.84 95%CI 1.25-2.70), previous heart diseases (OR 1.62 95%CI 1.13-2.32), diabetes mellitus (OR 1.61 95%CI 1.13-2.32), and a PMD value over 66 HU (OR 0.58 95%CI 0.39-0.84) acted as independent predictors of long-term mortality in the Cox's proportional hazards model. Heart diseases (congestive heart failure or coronary artery disease), serum creatinine levels over 1.05 mg/dL, and an aneurysm diameter over 60 mm were independent predictors of major complications.

Conclusion: Surrogate markers of sarcopenia had a poor predictive profile for postoperative mortality after AAA repair in our sample. However, PMD stood out as an independent predictor of long-term mortality. This finding can guide future research and should be confirmed in larger datasets.

目的:有几种预测模型可用于估计腹主动脉瘤(AAA)修复术后风险,但没有一种特定工具得到广泛应用。我们展示了一项多中心、历史性队列研究的结果,该研究比较了腰肌面积(PMA)、放射性密度(PMD)和瘦肌肉面积(LMA)作为肌肉疏松症的替代指标,与 mFI-5 和美国麻醉医师协会(ASA)量表相比,对 AAA 修复术后短期和长期结果的预测能力:方法:对2014年至2019年期间三个三级医疗中心的所有连续AAA选择性修复病例(开放或血管内)进行回顾性审查。由两名独立操作者在术前计算机断层扫描中测量 L3 椎体中段的横截面 PMA、PMD 和 LMA。使用接收者操作特征曲线(ROC)确定最佳截断值。建立了双变量分析、逻辑回归和考克斯比例危险模型,以研究基线变量与术后死亡率、长期死亡率和并发症之间的关系:共纳入 596 名患者(平均年龄为 72.7 ± 8 岁,95.1% 为男性,66.9% 为 EVAR)。围手术期死亡率为2.3%(EVAR为1.2%,开放式修复为4.6%,P = .015),多变量分析中未发现独立的预测因素。相反,年龄超过 74 岁(OR 1.84 95%CI 1.25-2.70)、曾患心脏病(OR 1.62 95%CI 1.13-2.32)、糖尿病(OR 1.61 95%CI 1.13-2.32)和 PMD 值超过 66 HU(OR 0.58 95%CI 0.39-0.84)在 Cox 比例危险模型中成为长期死亡率的独立预测因素。心脏病(充血性心力衰竭或冠状动脉疾病)、血清肌酐水平超过1.05 mg/dL和动脉瘤直径超过60 mm是主要并发症的独立预测因素:结论:在我们的样本中,代用指标 "肌肉疏松症 "对 AAA 修复术后死亡率的预测性较差。然而,PMD 是预测长期死亡率的独立指标。这一发现可以指导未来的研究,并应在更大的数据集中得到证实。
{"title":"Psoas muscle analysis as a surrogate marker of sarcopenia and frailty: A multicenter analysis of predictive capacities over short- and long-term outcomes after abdominal aortic aneurysm repair.","authors":"Rocío Vázquez Pérez, Francisco Álvarez Marcos, Cristina Tello Díaz, Sergi Bellmunt Montoya, Rafael Fernández-Samos Gutiérrez, Daniel Gil Sala","doi":"10.1177/17085381231193453","DOIUrl":"10.1177/17085381231193453","url":null,"abstract":"<p><strong>Objectives: </strong>Several predictive models exist for estimating the postoperative risks of abdominal aortic aneurysm (AAA) repair, although no particular tool has seen widespread use. We present the results of a multicenter, historic cohort study comparing the predictive capacity of the psoas muscle area (PMA), radiodensity (PMD), and lean muscle area (LMA) as surrogate markers of sarcopenia, over short- and long-term outcomes after AAA repair, compared to the mFI-5 and American Society of Anesthesiologists (ASA) scales.</p><p><strong>Methods: </strong>Retrospective review was conducted of all consecutive AAA elective repair cases (open or endovascular) in three tertiary-care centers from 2014 to 2019. Cross-sectional PMA, PMD, and LMA at the mid-body of the L3 vertebra were measured by two independent operators in the preoperative computed tomography. Receiver operating characteristic (ROC) curves were used to determine optimal cutoff values. Bivariate analysis, logistic regression, and Cox's proportional hazards models were built to examine the relationship between baseline variables and postoperative mortality, long-term mortality, and complications.</p><p><strong>Results: </strong>596 patients were included (mean age 72.7 ± 8 years, 95.1% male, 66.9% EVAR). Perioperative mortality was 2.3% (EVAR 1.2% vs open repair 4.6%, <i>p</i> = .015), and no independent predictors could be identified in the multivariate analysis. Conversely, an age over 74 years old (OR 1.84 95%CI 1.25-2.70), previous heart diseases (OR 1.62 95%CI 1.13-2.32), diabetes mellitus (OR 1.61 95%CI 1.13-2.32), and a PMD value over 66 HU (OR 0.58 95%CI 0.39-0.84) acted as independent predictors of long-term mortality in the Cox's proportional hazards model. Heart diseases (congestive heart failure or coronary artery disease), serum creatinine levels over 1.05 mg/dL, and an aneurysm diameter over 60 mm were independent predictors of major complications.</p><p><strong>Conclusion: </strong>Surrogate markers of sarcopenia had a poor predictive profile for postoperative mortality after AAA repair in our sample. However, PMD stood out as an independent predictor of long-term mortality. This finding can guide future research and should be confirmed in larger datasets.</p>","PeriodicalId":23549,"journal":{"name":"Vascular","volume":" ","pages":"973-982"},"PeriodicalIF":1.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9914705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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