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Modelling an Extraterrestrial Epidemic 模拟外星流行病
R. Deonandan, S. Litvinjenko
Panspermia is the theory that life has been transported between bodies in the solar system by means of asteroid or cometary impact. Assuming that panspermia is true, and that genetically related microbial life exists outside of our planet, then it is possible that such life could pose an infectious threat to the terrestrial biosphere. We offer several assumptions of the characteristics that such life might possess and extrapolate the likely epidemiological compartment approach to be applied when attempting to model the impact of an Earthly epidemic originating from an extraterrestrial pathogen.
生源说是指生命通过小行星或彗星的撞击在太阳系的天体之间传播的理论。假设生源论是正确的,并且与遗传相关的微生物生命存在于我们的星球之外,那么这些生命可能会对陆地生物圈构成传染性威胁。我们对这种生命可能具有的特征提出了若干假设,并推断出在试图模拟源自地外病原体的地球流行病的影响时可能采用的流行病学分区方法。
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引用次数: 0
Mental Model of Mothers of Adolescent Girls and Health Service Providers on HPV Vaccination in Urban Slum Areas of Dhaka, Bangladesh: A Mixed-Method Study 孟加拉国达卡城市贫民窟地区少女母亲和卫生服务提供者对HPV疫苗接种的心理模型:一项混合方法研究
Background: The study aimed to explore the perception of mothers of adolescent girls and health service providers in urban slums toward HPV vaccination. Methodology: A cross-sectional mixed-method study in the slums of Rayer Bazaar, Kamlapur and Mohakhali was conducted. The quantitative part included a household survey of mothers (n=150) and service providers (n=30) through a semi-structured pre-tested questionnaire and qualitative interviews included in-depth interviews (IDI) with mothers (n=10) and key-informant interviews (KII) with service providers (n=10). Results: Around 96% of mothers had never heard of HPV, and 98% were unaware that the virus's transmission could be halted. Only 3.3% of mothers were aware that HPV can cause cervical cancer, although, during IDI, it was seen that the majority of mothers said that cervical cancer is a communicable disease. Nearly 98% of mothers wanted their daughters to get vaccinated. Service providers had a good understanding of HPV, HPV vaccine, and cervical cancer. All service providers during KII agreed that if they had received adequate training on HPV vaccination and cervical cancer, they could have treated their patients better. Conclusion: The findings of this study have important implications for the design and advocacy of HPV immunization programs in Bangladesh.
背景:本研究旨在探讨城市贫民窟少女母亲和卫生服务提供者对HPV疫苗接种的看法。方法:在Rayer Bazaar, Kamlapur和Mohakhali的贫民窟进行了横断面混合方法研究。定量部分包括通过半结构化预测试问卷对母亲(n=150)和服务提供者(n=30)进行的家庭调查,定性访谈包括对母亲(n=10)的深度访谈(IDI)和对服务提供者(n=10)的关键信息提供者访谈(KII)。结果:大约96%的母亲从未听说过HPV, 98%的母亲不知道病毒的传播可以被阻止。只有3.3%的母亲知道人乳头瘤病毒可导致子宫颈癌,尽管在IDI期间,大多数母亲说子宫颈癌是一种传染病。近98%的母亲希望自己的女儿接种疫苗。服务提供者对HPV、HPV疫苗和宫颈癌有很好的了解。KII期间的所有服务提供者都同意,如果他们接受了关于HPV疫苗接种和宫颈癌的充分培训,他们可以更好地治疗患者。结论:本研究结果对孟加拉国HPV免疫规划的设计和宣传具有重要意义。
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引用次数: 0
Anesthesia Management of Sectio Caesarian Patients with Eisenmenger Syndrome and Fetal Distress 艾森曼格综合征合并胎儿窘迫剖宫产患者的麻醉处理
Indriasari ., I. Fuadi, R. W. Sudjud, I. .
Brief overview: 27 year old woman, G2P1A0 gravida 35-36 weeks with congenital heart disease (ventricular septal defect) that progresses to Eisenmenger syndrome, respiratory failure and fetal distress underwent an emergency caesarean section. Management: Anesthesia management was performed under general anesthesia with post-operative care in ICU. Prior to induction, pre-oxygenated with 100% O2 was performed, followed by Rapid Sequence Induction with Ketamine 70 mg, and Rocuronium 50 mg. After the patient had fallen asleep the Sellick maneuver was performed, intubated with ETT no. 6.5. Anesthesia maintenance with Sevoflurane 1 vol%, and 100% oxygen. Fentanyl 50 μg was given after the baby was born. Outcome: In this patient, general anesthetic technique was preferred over regional anesthetic technique for better maternal and fetal outcomes because this patient had already experienced respiratory failure and fetal distress, so a caesarean section was decided as soon as possible. The operation lasted for two hours, with SpO2 during the operation reaching 85% and a live baby boy was born with APGAR scores at the 1st ,3rd and 5th minute 6. Postoperatively, the patient remained intubated and was transferred to the intensive care unit with vital signs blood pressure 122/80 mmHg, pulse 96 beats per minute, SpO2 82-85%.
摘要:27岁女性,G2P1A0孕35-36周,先天性心脏病(室间隔缺损)进展为艾森门格综合征,呼吸衰竭和胎儿窘迫,接受紧急剖腹产手术。管理:麻醉管理在全麻下进行,术后护理在ICU进行。诱导前,100% O2预充氧,随后氯胺酮70 mg,罗库溴铵50 mg快速序列诱导。患者入睡后进行Sellick手法,插管ETT no。6.5. 麻醉维持用七氟醚1vol %, 100%供氧。婴儿出生后给予芬太尼50 μg。结果:本例患者已经出现呼吸衰竭和胎儿窘迫,因此尽快决定剖宫产,全麻优于区域麻醉,母婴结局更好。手术持续2小时,术中SpO2达到85%,1例男婴活产,APGAR评分分别为1、3、5分钟6。术后患者继续插管,转重症监护病房,生命体征血压122/80 mmHg,脉搏96次/分,SpO2 82-85%。
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引用次数: 0
Bullous Pemphigoid in a 37-Year Old Female: A Case Report and Literature Review 37岁女性大疱性类天疱疮1例报告并文献复习
Stefon Monique D. Oxley, Brian M. Denney
Bullous pemphigoid is a blistering disorder which mainly affects the geriatric population predominantly older than 70 years. It is caused by an autoimmune reaction to the hemidesmosomal proteins in basal keratinocytes, causing an inflammatory cascade and subsequent bullae formation. It is rarely encountered in infants, children, and middle-aged adults. Herein, a case of Bullous pemphigoid in a 37-year old female patient is reported. The patient presented with a three-month history of multiple serous fluid-filled tense blisters on the face, neck, trunk, flexor and extensor surfaces of the extremities up to the lower thigh, with areas of excoriation, peeling, erosion and crusting. No involvement of the mucous membranes noted. The lesions were associated with intense pruritus and pain upon rupture. Patient had no other subjective complaints and had an unremarkable past medical history. Patient was initially treated with antibiotics but noted no improvement in her condition. Histologic evaluation of the skin was done and revealed a subepidermal vesicular dermatitis with prominent neutrophilic infiltrates. No hyphae or spores were seen. With these findings, patient was admitted and treated with systemic steroids, antibiotics, and antipruritic medications. Direct Immunofluorescence was done and yielded findings consistent with the diagnosis of Bullous Pemphigoid. The overall response of the patient to therapy was satisfactory. The differentiation of Bullous pemphigoid from other subepidermal bullous diseases is important due to the potential of systemic manifestations and complications of the other diseases. The importance of clinical, histopathologic and immunologic findings in confirming the diagnosis of Bullous Pemphigoid is highlighted in this case report.
大疱性类天疱疮是一种起泡性疾病,主要影响70岁以上的老年人。它是由自身免疫对基底角化细胞中半粒染色体蛋白的反应引起的,引起炎症级联和随后的大泡形成。在婴儿、儿童和中年人中很少遇到。在此,我们报告一位37岁女性病患的大疱性类天疱疮。患者有3个月的面部、颈部、躯干、四肢屈肌和伸肌表面多处浆液充盈的紧张性水泡病史,直至大腿下部,伴有擦伤、脱皮、糜烂和结痂。未见粘膜受累。病灶在破裂时伴有强烈的瘙痒和疼痛。患者无其他主诉,既往病史一般。患者最初接受抗生素治疗,但未见病情改善。对皮肤进行组织学检查,发现皮下水疱性皮炎伴明显的中性粒细胞浸润。未见菌丝或孢子。根据这些发现,患者入院并接受全身类固醇、抗生素和抗瘙痒药物治疗。直接免疫荧光检查结果与大疱性类天疱疮的诊断一致。患者对治疗的总体反应令人满意。大疱性类天疱疮与其他表皮下大疱性疾病的区别是重要的,因为其他疾病可能有全身表现和并发症。本病例报告强调了临床、组织病理学和免疫学结果在确诊大疱性类天疱疮中的重要性。
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引用次数: 0
Islamic Perspective on Organ Donation and Brain Death 伊斯兰教对器官捐赠和脑死亡的看法
Ahmad Khan, Melanie M. Tidman
Worldwide and in the countries, Islamic scholars do not have a consensus on the criteria and definition of brain death. This lack of consensus on the definition of brain death and its legal status has resulted in delays in withdrawal of care and futile care to the brain-dead patient population that negatively strains the limited resources for human organs in the Islamic community. Also, Islamic countries with organ transplantation resources lack legislation on endorsing brain death and its legal status as death which creates delays in harvesting viable organs from eligible donors. These delays can negatively impact the life quality of patients with end-organ failure waiting for an organ and make organs non-viable for transplantation, adding to the already existing shortages in Islamic countries. This brief review aims to clarify some of the barriers in the determination of brain death and organ donation in Islamic countries and address religious and ethical issues that exist that affect issues of access.
在世界范围内和国内,伊斯兰学者对脑死亡的标准和定义没有达成共识。由于对脑死亡的定义及其法律地位缺乏共识,导致对脑死亡患者的护理延迟和护理无效,从而使伊斯兰社会有限的人体器官资源紧张。此外,拥有器官移植资源的伊斯兰国家缺乏认可脑死亡及其作为死亡的法律地位的立法,这造成了从符合条件的捐赠者那里获取可行器官的延误。这些延误会对等待器官移植的终末器官衰竭患者的生活质量产生负面影响,并使器官无法进行移植,加剧了伊斯兰国家已经存在的器官短缺问题。这一简短审查的目的是澄清伊斯兰国家在确定脑死亡和器官捐赠方面的一些障碍,并解决影响获取问题的现存宗教和伦理问题。
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引用次数: 0
Evaluation of Health Promoting Schools Programme in Saudi Arabia 沙特阿拉伯健康促进学校方案评价
S. Arabia, S. Alzahrani
Background: The health-promoting school (HPS) is a WHO-sponsored framework. This national study aimed to explore the experiences and progress in implementing the HPS programme in Saudi Arabia (SA). Methods: A self-completed postal questionnaire was sent to all 42 school health departments across SA, and the response rate was 100%. Results: Forty respondents (95%) had implemented the HPS programme. Over 400 schools were involved in the HPS programme of which two-thirds were primary schools. The most common activities addressed were health education activities. Less frequently mentioned were healthy school policies, action on the social environment, and developing links with the community. Evaluation was only through internal processes. The main perceived strengths of the HPS were increasing the awareness of students and school staff and improving the school’s physical environment. The main weakness was the lack of legislation and financial support. For further development, the respondents reported the need for financial and human support. Conclusion: This study highlights the growth of the schools participating in the HPS programme. Further research is needed to develop and fully evaluate the effectiveness of the HPS framework in SA.
背景:健康促进学校(HPS)是世卫组织赞助的框架。本研究旨在探讨沙特阿拉伯(SA)实施HPS计划的经验和进展。方法:以邮寄方式向南达科他州42所学校卫生部门寄送自行填写的问卷,回复率为100%。结果:40名受访者(95%)实施了HPS方案。400多所学校参与了公共卫生服务方案,其中三分之二是小学。最常见的活动是卫生教育活动。较少提及的是健康的学校政策、社会环境行动以及发展与社区的联系。评价只能通过内部程序进行。人们认为HPS的主要优势是提高了学生和学校员工的意识,改善了学校的物理环境。主要的弱点是缺乏立法和财政支持。为了进一步发展,答复者报告需要财政和人力支助。结论:这项研究突出了参与HPS项目的学校的增长。需要进一步的研究来开发和充分评估HPS框架在SA中的有效性。
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引用次数: 1
Uses of Artificial Intelligence in Psychology 人工智能在心理学中的应用
S. Irshad, S. Azmi, N. Begum
Machine learning has a new landscape for humanity in the area of artificial intelligence (AI). Artificial intelligence (AI) approaches have recently been developed to support mental health professionals, primarily psychiatrists, psychologists, and clinicians, with decision-making based on patients' historical data (e.g., clinical history, behavioral data, social media use, etc.). This article reviews developments in artificial intelligence (AI) technologies and their current and potential applications in clinical psychological practice. Issues associated with AI in the context of clinical practice, the potential risk for job loss among mental health professionals, and other ramifications associated with the advancement of AI technology are discussed. The advancement of AI technologies and their application in psychological practice have important implications that can be expected to transform the mental health care field. Psychologists and other mental health care professionals have an essential part to play in the development, evaluation, and ethical use of AI technologies.
机器学习在人工智能(AI)领域为人类带来了新的景观。人工智能(AI)方法最近被开发出来,用于支持精神卫生专业人员,主要是精神病学家、心理学家和临床医生,根据患者的历史数据(例如,临床病史、行为数据、社交媒体使用等)做出决策。本文综述了人工智能(AI)技术的发展及其在临床心理学实践中的当前和潜在应用。讨论了在临床实践中与人工智能相关的问题、精神卫生专业人员失业的潜在风险以及与人工智能技术进步相关的其他后果。人工智能技术的进步及其在心理学实践中的应用具有重要意义,有望改变精神卫生保健领域。心理学家和其他精神卫生保健专业人员在人工智能技术的开发、评估和道德使用方面发挥着重要作用。
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引用次数: 1
Assessment of Reproductive Health Status and Quality of Life of Female Adolescents Living in the Slums of Dhaka, Bangladesh During COVID-19 Pandemic Situation: A Mixed-Method Study COVID-19大流行期间孟加拉国达卡贫民窟女性青少年生殖健康状况和生活质量评估:一项混合方法研究
Hridi Hridi, F. Haseen, T. Sharmin, Syfunnahar Bristy, Nurjahan Akter, Umme Haney, Barna Biswas, Mahmuda Ali, Zobaidur Rahman, S. Islam
Background: The COVID-19 pandemic has exacerbated the challenges of vulnerable adolescents who had reproductive health problems even before the COVID-19 pandemic. Methodology: We investigated this vulnerability through cross-sectional studies with a mixed-method approach. on female adolescents aged 15-19 years, residing in the Bauniabadh and the Ta block Jhil Par slums together with service providers. The quantitative method included a household survey of adolescents (n=144) through a semi-structured pre-tested questionnaire. The qualitative method included interviews with service providers (n=10) and with adolescents (n=9). Result: The study revealed changes in length, duration and flow of menstruation, substandard menstrual hygiene practices and impediments to the uptake of reproductive health (RH) information by adolescents during the pandemic. Married pregnant adolescents are inclined in taking their antenatal checkups (ANC) only during the last trimester and preferred delivery at home during the pandemic. There was also an increase in marriage among these adolescents and service providers had difficulty providing door-to-door RH services. Most of our female adolescents were married off during the pandemic, they lost connection with their friends and this made them feel lonely and secluded. They did not receive the support of their friends as before the pandemic. Conclusion: The study will enable the adolescent health expert to focus on the sexual and reproductive health (SRH) of vulnerable adolescents living in impoverished conditions during the COVID-19 pandemic.
背景:2019冠状病毒病大流行加剧了弱势青少年面临的挑战,他们在2019冠状病毒病大流行之前就存在生殖健康问题。方法:我们通过混合方法的横断面研究来调查这一脆弱性。与服务提供者一起居住在Bauniabadh和Ta block Jhil Par贫民窟的15-19岁女青少年。定量方法包括通过半结构化预测问卷对青少年进行家庭调查(n=144)。定性方法包括对服务提供者(n=10)和青少年(n=9)的访谈。结果:该研究揭示了月经长度、持续时间和流量的变化,月经卫生习惯不达标,以及青少年在大流行期间接受生殖健康(RH)信息方面的障碍。已婚怀孕少女倾向于只在最后三个月进行产前检查,在大流行期间更倾向于在家中分娩。这些青少年的结婚率也有所增加,服务提供者难以提供上门生殖健康服务。我们的大多数女性青少年在大流行期间嫁出去了,她们与朋友失去了联系,这使她们感到孤独和与世隔绝。他们没有像大流行前那样得到朋友的支持。结论:该研究将使青少年健康专家能够在COVID-19大流行期间关注生活在贫困条件下的弱势青少年的性健康和生殖健康(SRH)。
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引用次数: 0
A Study on Distribution and Association of CD320, a Receptor for Active Vitamin B12, in Pregnant Mothers and their Newborns Cord Blood 活性维生素B12受体CD320在孕妇及其新生儿脐带血中的分布及相关性研究
M. Surekha, Gadhiraju S, K. Satyanarayana, P. U. Kumar
Objective: Our objective was to study the levels and relation between CD320 receptors in anaemic mothers in their last trimester of pregnancy and their newborns after birth. Methods: Association between CD320, VitB12, active B12 levels in mothers with anaemia were analysed before they underwent labor and in blood collected from their newborns after labor. Regression analysis was performed in order to assess the relation between the mothers and their neonatal vitamin CD320 levels in relation to their Vit B12 status. Results: Among the 200 pregnant mothers recruited, 59% were anaemic. CD320 levels were significantly higher in anaemic mothers (414.09 ±10.75 pg/ml) when compared with cord blood (372.25 ± 7.81 pg/ml). CD320 levels were higher in both mother and cord blood with Vit B12 deficiency, however, were lower in mothers with active B12 deficiency. CD320 levels in cord blood were positively associated with haemoglobin (r value 0.8, p value 0.42) of mothers and negatively with serum folate (r value -0.15; p value 0.23), Vit B12(r value -0.21; p value0.28) and active Vit B12 levels (r value -0.25; p value0.03) in mothers. Conclusion: CD320 levels in cord blood positively correlated with haemoglobin of mothers and negatively with folic acid and B12 status. A negative trend (p=0.0024) was observed between maternal and neonatal CD320 levels.
目的:我们的目的是研究妊娠末三个月贫血母亲与出生后新生儿中CD320受体的水平及其关系。方法:分析贫血母亲分娩前和分娩后新生儿血液中CD320、维生素B12、活性B12水平之间的关系。为了评估母亲及其新生儿维生素CD320水平与维生素B12状态之间的关系,进行了回归分析。结果:在招募的200名孕妇中,59%为贫血。贫血母亲的CD320水平(414.09±10.75 pg/ml)明显高于脐带血(372.25±7.81 pg/ml)。维生素B12缺乏的母亲和脐带血中的CD320水平都较高,而维生素B12缺乏的母亲的CD320水平较低。脐带血CD320水平与母亲血红蛋白呈正相关(r值0.8,p值0.42),与血清叶酸呈负相关(r值-0.15;p值0.23),维生素B12(r值-0.21;p值0.28)和活性维生素B12水平(r值-0.25;P值为0.03)。结论:脐带血CD320水平与母亲血红蛋白呈正相关,与叶酸和B12水平呈负相关。产妇和新生儿CD320水平呈负相关(p=0.0024)。
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引用次数: 0
Indonesian Christian Community’s Perspective on Pharmacists and Medicine 印尼基督徒社区对药剂师和医学的看法
Didiek Hardiyanto, Holy Rhema Soegiantoro, Gregory Hope Soegiantoro
The use of drugs and the responsibility of pharmacists in the treatment process for the Indonesian Christian community face challenges in understanding biblical health doctrines especially in the use of drugs and the provision of advice by pharmacists. The view that medicine as a product of science is contrary to faith and belief in God's care for the health of the human body is a theological distortion. the pharmacist’s role is equated with relying on humans and not relying on God. This study assesses perspectives on medicine and pharmacists in the Indonesian Christian community. This research is a descriptive study using questionnaire. Respondents were randomly selected from all provinces in Indonesia following the proportion of the Christian population in the province. The validity and reliability of the questionnaire were tested using the composite reliability (CR) method and Cronbach's alpha with a significance level of 5%. The questionnaire was assessed using a Likert scale and the results were classified into very good, good, and poor. This study shows the community's perspective on medicine still needs to be improved (32.6% very good, 40.6% good, and 26.8% poor). For Indonesian Christian community, the hesitation to use medicine is caused by the teaching that faith and God's promises in the Bible are sufficient to heal and maintain human health. While the perspective of pharmacists in the treatment process shows better results (45.4% very good, 36.2% good, and 18.4% poor).
在印度尼西亚基督教社区的治疗过程中,药物的使用和药剂师的责任在理解圣经健康教义方面面临挑战,特别是在药物的使用和药剂师提供咨询方面。认为医学是科学的产物是违背信仰和相信上帝关心人体健康的观点是一种神学上的扭曲。药剂师的角色等同于依靠人类而不是依靠上帝。本研究评估了印尼基督教社区对医学和药剂师的看法。本研究采用问卷调查法进行描述性研究。受访者是根据印尼各省基督徒人口的比例随机抽取的。问卷的效度和信度采用复合信度法和Cronbach’s alpha进行检验,显著性水平为5%。问卷采用李克特量表进行评估,结果分为非常好、好和差。该研究显示,社区对医学的看法仍需改进(32.6%非常好,40.6%好,26.8%差)。对于印尼的基督徒群体来说,使用药物的犹豫是因为他们认为信仰和上帝在圣经中的应许足以治愈和维持人类的健康。药师在治疗过程中的表现较好(45.4%非常好,36.2%良好,18.4%较差)。
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引用次数: 0
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World Academy of Science, Engineering and Technology, International Journal of Medical and Health Sciences
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