O. Olisova, O. Svitich, A. Poddubikov, N. Vartanova, M. Potapova
Background: Atopic dermatitis is an inflammatory skin disease characterized by recurrent lesions and intense pruritus. Nowadays there is a stepwise approach to the treatment of atopic dermatitis, which is defined by disease intensity and complications such as secondary skin infections. However, the current management of atopic dermatitis may not always lead to the expected outcome due to not only immune dysregulation of both adaptive and innate immunity but also imbalance of the skin microbiome. Aims: The aim of the study was to evaluate changes in the composition of the skin microbiome in patients with atopic dermatitis during standard treatment. Materials and methods: Twenty patients with atopic dermatitis and twenty six healthy controls over 18 years old were included into the study. All microbiome samples were obtained from lesional and non-lesional skin sites of atopic dermatitis patients before and after therapy. Whereas samples from healthy controls were taken once from a flexor surface of the elbow. Species identification of clinical isolates were identified using MALDI Biotyper Sirius (Bruker Daltonics). Results: At baseline, the prevalence of S. aureus colonization among patients with atopic dermatitis was 34,20% in lesional skin and 32.50% in non-lesional skin. After therapy, the rate of S. aureus carriage decreased by 1.6 times (21.60%) in affected and by 2 times (15.6%) in unaffected skin. Interestingly, S. aureus was not found in healthy controls. Moreover, a quantitative estimation of S. aureus growth also demonstrated significant changes in the degree of colonization after treatment. The prevalence of confluent growth of S. aureus in inflamed atopic skin decreased more than 5 times. Conclusions: Thus, the results of the study showed the effectiveness of standard therapy for managing patients with atopic dermatitis by having a positive impact on the skin microbial community. There was a significant shift in both the qualitative and quantitative presence of S. aureus on the skin surface.
{"title":"Microbiological assessment of the effectiveness of standard therapy in atopic dermatitis.","authors":"O. Olisova, O. Svitich, A. Poddubikov, N. Vartanova, M. Potapova","doi":"10.25208/vdv1364","DOIUrl":"https://doi.org/10.25208/vdv1364","url":null,"abstract":"Background: Atopic dermatitis is an inflammatory skin disease characterized by recurrent lesions and intense pruritus. Nowadays there is a stepwise approach to the treatment of atopic dermatitis, which is defined by disease intensity and complications such as secondary skin infections. However, the current management of atopic dermatitis may not always lead to the expected outcome due to not only immune dysregulation of both adaptive and innate immunity but also imbalance of the skin microbiome. Aims: The aim of the study was to evaluate changes in the composition of the skin microbiome in patients with atopic dermatitis during standard treatment. Materials and methods: Twenty patients with atopic dermatitis and twenty six healthy controls over 18 years old were included into the study. All microbiome samples were obtained from lesional and non-lesional skin sites of atopic dermatitis patients before and after therapy. Whereas samples from healthy controls were taken once from a flexor surface of the elbow. Species identification of clinical isolates were identified using MALDI Biotyper Sirius (Bruker Daltonics). Results: At baseline, the prevalence of S. aureus colonization among patients with atopic dermatitis was 34,20% in lesional skin and 32.50% in non-lesional skin. After therapy, the rate of S. aureus carriage decreased by 1.6 times (21.60%) in affected and by 2 times (15.6%) in unaffected skin. Interestingly, S. aureus was not found in healthy controls. Moreover, a quantitative estimation of S. aureus growth also demonstrated significant changes in the degree of colonization after treatment. The prevalence of confluent growth of S. aureus in inflamed atopic skin decreased more than 5 times. Conclusions: Thus, the results of the study showed the effectiveness of standard therapy for managing patients with atopic dermatitis by having a positive impact on the skin microbial community. There was a significant shift in both the qualitative and quantitative presence of S. aureus on the skin surface.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42614143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julia Shagabieva, N. Nosov, Marina Valentinovna Shpilevaja, D. Deryabin, Olga Obraztcova, Evgenia Nikonorova, A. Kubanov, V. Solomka
Based on data from 16 years of the N. gonorrhoeae antibiotic resistance monitoring program. gonorrhoeae in the Russian Federation were analyzed according to the minimum suppressive concentrations (MSC) of antimicrobial drugs against gonococcal strains obtained and characterized at the State Scientific and Research Center for Drug Control of the Ministry of Health of Russia. We constructed polynomial trends in the frequency of occurrence of different susceptibility groups by year and analyzed them further. Based on the analysis of polynomial trends of fluctuating frequencies of strains with different sensitivity to AMF, conclusions were made about the dynamics of antibiotic resistance of N. gonorrhoeae for the period 2005-2021.
{"title":"Analysis of the dynamics of the IPC of antimicrobials against \u0000N. gonorrhoeae in the Russian Federation for the period 2005-2021.","authors":"Julia Shagabieva, N. Nosov, Marina Valentinovna Shpilevaja, D. Deryabin, Olga Obraztcova, Evgenia Nikonorova, A. Kubanov, V. Solomka","doi":"10.25208/vdv1410","DOIUrl":"https://doi.org/10.25208/vdv1410","url":null,"abstract":"Based on data from 16 years of the N. gonorrhoeae antibiotic resistance monitoring program. gonorrhoeae in the Russian Federation were analyzed according to the minimum suppressive concentrations (MSC) of antimicrobial drugs against gonococcal strains obtained and characterized at the State Scientific and Research Center for Drug Control of the Ministry of Health of Russia. We constructed polynomial trends in the frequency of occurrence of different susceptibility groups by year and analyzed them further. Based on the analysis of polynomial trends of fluctuating frequencies of strains with different sensitivity to AMF, conclusions were made about the dynamics of antibiotic resistance of N. gonorrhoeae for the period 2005-2021.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49184793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nina Petrovna Toropova is a prominent Russian scientist, Doctor of Medical Sciences, Professor, Honored Doctor of the Russian Federation, founder of the Ural Scientific School of Pediatric Dermatology, from 1987 to 2001 - Chief Freelance Pediatric Dermatovenerologist of the Ministry of Health of the Russian Federation, from 1982 to 2009 - Chief Freelance Pediatric dermatovenereologist of the Ministry of Health of the Sverdlovsk region. For many years N.P. Toropova was the Deputy Director for Research at the Ural Research Institute of Dermatovenereology and Immunopathology; from 1993 to 2001 - Director of the Sverdlovsk Scientific and Practical Center for Pediatric Dermatology and Venereology.
{"title":"Nina Petrovna Toropova","authors":"Helen Sukhacheva","doi":"10.25208/vdv8898","DOIUrl":"https://doi.org/10.25208/vdv8898","url":null,"abstract":"Nina Petrovna Toropova is a prominent Russian scientist, Doctor of Medical Sciences, Professor, Honored Doctor of the Russian Federation, founder of the Ural Scientific School of Pediatric Dermatology, from 1987 to 2001 - Chief Freelance Pediatric Dermatovenerologist of the Ministry of Health of the Russian Federation, from 1982 to 2009 - Chief Freelance Pediatric dermatovenereologist of the Ministry of Health of the Sverdlovsk region. For many years N.P. Toropova was the Deputy Director for Research at the Ural Research Institute of Dermatovenereology and Immunopathology; from 1993 to 2001 - Director of the Sverdlovsk Scientific and Practical Center for Pediatric Dermatology and Venereology.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46516034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aromatic hydrocarbon receptor (AhR) is a cytoplasmic receptor and transcription factor that regulates a wide range of biological and toxicological effects by binding to specific ligands. Among the effects there is detoxification of xenobiotics, maintenance of tissue homeostasis, regulation of the immune response. The structure and functions of AhR are described in the review. The mechanisms of skin homeostasis with the participation of the aromatic hydrocarbon receptor such as the effect on oxidative reactions and participation in maintaining the barrier function of the epidermis are demonstrated in details. The role of AhR in the pathogenesis of atopic dermatitis is discussed. The participation of AhR in the implementation of immune mechanisms of this disease as well as in the regulation of the production of key proteins of the skin barrier is shown. The data on the therapeutic value of its pharmacological modulation including the results of clinical studies of the topical ligand AhR Tapinarof are presented. The role of the aromatic hydrocarbon receptor in the realization of the effect of phototherapy of atopic dermatitis is demonstrated.
{"title":"The role of the aromatic hydrocarbon receptor in the pathogenesis of atopic dermatitis","authors":"P. V. Gorodnichev","doi":"10.25208/vdv4775","DOIUrl":"https://doi.org/10.25208/vdv4775","url":null,"abstract":"The aromatic hydrocarbon receptor (AhR) is a cytoplasmic receptor and transcription factor that regulates a wide range of biological and toxicological effects by binding to specific ligands. Among the effects there is detoxification of xenobiotics, maintenance of tissue homeostasis, regulation of the immune response. The structure and functions of AhR are described in the review. The mechanisms of skin homeostasis with the participation of the aromatic hydrocarbon receptor such as the effect on oxidative reactions and participation in maintaining the barrier function of the epidermis are demonstrated in details. The role of AhR in the pathogenesis of atopic dermatitis is discussed. The participation of AhR in the implementation of immune mechanisms of this disease as well as in the regulation of the production of key proteins of the skin barrier is shown. The data on the therapeutic value of its pharmacological modulation including the results of clinical studies of the topical ligand AhR Tapinarof are presented. The role of the aromatic hydrocarbon receptor in the realization of the effect of phototherapy of atopic dermatitis is demonstrated.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45467335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. N. Kondrakhina, Dmitriy A. Verbenko, A. M. Zatevalov, D. Deryabin
Background: The initial stages of androgenetic alopecia in men are characterized by a variety of clinical manifestation in the parietal or occipital scalp regions. However, the differences in the pathogenesis of hair loss patterns are not well understood, selective treatment has not been developed. Aims: Trichological characteristics of patients with initial stages of androgenetic alopecia with identification of genetic and non-genetic factors that determine the hair loss in the different scalp regions, and their response to conservative therapy. Materials and methods: Trichograms were photodocumented using an AramoSG microcamera (Republic of Korea). The genetic factor was analyzed by mini-sequencing of single nucleotide polymorphisms rs929626, rs5919324, rs1998076, rs12565727, rs756853. The non-genetic factors study included hormonal status (total and free testosterone, dihydrotestosterone, 17OH-progesterone, dehydroepiandrostenone, SHBG) and blood content of trace elements (Mg, Ca, Zn, Cu, Se, Fe) and vitamins (B12, D, E, folic acid). Conservative treatment was topical application of a minoxidil 5% (twice-a-day, 4 months) and a micronutrient deficiencies personalized correction. Results: The study included 47 man with initial stages of androgenetic alopecia. Their trichological examination showed two patterns, consisting a predominant decrease in the hair density and diameter in the parietal and occipital scalp regions, which were subgroups formation criteria. An intergroup comparison revealed similar genetic risk, while hormonal parameters (increased dihydrotestosterone levels, a decrease in free testosterone) characterized the subgroup with parietal hair loss pattern. Also, a multiple deficiency of Zn, Cu, Se and vitamins B12, D, folic acid was detected in all patients. Subsequent conservative treatment had a positive effect in patients with parietal hair loss pattern, while in patients with occipital pattern no significant response was observed. Conclusions: The study develops ideas about differences between androgen-dependent parietal and androgen-independent occipital hair loss patterns in the initial stages of androgenetic alopecia, which requires different approaches to their conservative therapy.
{"title":"PARIETAL AND OCCIPITAL HAIR LOSS PATTERNS IN INITIAL STAGES OF ANDROGENIC ALOPECIA IN MEN","authors":"I. N. Kondrakhina, Dmitriy A. Verbenko, A. M. Zatevalov, D. Deryabin","doi":"10.25208/vdv1409","DOIUrl":"https://doi.org/10.25208/vdv1409","url":null,"abstract":"Background: The initial stages of androgenetic alopecia in men are characterized by a variety of clinical manifestation in the parietal or occipital scalp regions. However, the differences in the pathogenesis of hair loss patterns are not well understood, selective treatment has not been developed. \u0000Aims: Trichological characteristics of patients with initial stages of androgenetic alopecia with identification of genetic and non-genetic factors that determine the hair loss in the different scalp regions, and their response to conservative therapy. \u0000Materials and methods: Trichograms were photodocumented using an AramoSG microcamera (Republic of Korea). The genetic factor was analyzed by mini-sequencing of single nucleotide polymorphisms rs929626, rs5919324, rs1998076, rs12565727, rs756853. The non-genetic factors study included hormonal status (total and free testosterone, dihydrotestosterone, 17OH-progesterone, dehydroepiandrostenone, SHBG) and blood content of trace elements (Mg, Ca, Zn, Cu, Se, Fe) and vitamins (B12, D, E, folic acid). Conservative treatment was topical application of a minoxidil 5% (twice-a-day, 4 months) and a micronutrient deficiencies personalized correction. \u0000Results: The study included 47 man with initial stages of androgenetic alopecia. Their trichological examination showed two patterns, consisting a predominant decrease in the hair density and diameter in the parietal and occipital scalp regions, which were subgroups formation criteria. An intergroup comparison revealed similar genetic risk, while hormonal parameters (increased dihydrotestosterone levels, a decrease in free testosterone) characterized the subgroup with parietal hair loss pattern. Also, a multiple deficiency of Zn, Cu, Se and vitamins B12, D, folic acid was detected in all patients. Subsequent conservative treatment had a positive effect in patients with parietal hair loss pattern, while in patients with occipital pattern no significant response was observed. \u0000Conclusions: The study develops ideas about differences between androgen-dependent parietal and androgen-independent occipital hair loss patterns in the initial stages of androgenetic alopecia, which requires different approaches to their conservative therapy.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47143548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. G. Artamonova, E. Monchakovskaya, A. Kubanov, M. Rakhmatulina, O. E. Kuznetsov, Darya А. Synkova, D. Verbenko
Diffuse cutaneous leishmaniasis is a rare form of cutaneous leishmaniasis characterized by an inadequate immune response of the host cells to parasitic invasion (weak T-helper (Th)1 response or Th2 response with the production of interleukin (IL)-4 and IL-10). The characteristic features of the disease include diffuse nodular eruption, masquerading as leprosy and a frequent association with immunosuppression (HIV co-infection, for example). The Russian Federation is a non-endemic country for leishmaniasis, but this disease can be brought into the country by tourists, immigrants, refugees and military personnel. A clinical case of diffuse cutaneous leishmaniasis and HIV co-infection is presented. The patient was a citizen of Uzbekistan, a country endemic for leishmaniasis. The authors were unable to find domestic scientific publications describing cases of diffuse cutaneous leishmaniasis detected in the Russian Federation. The presented clinical case of diffuse cutaneous leishmaniasis in a patient with HIV is the first in the Russian literature.
{"title":"A rare form of leishmaniasis, identified in the Russian Federation","authors":"O. G. Artamonova, E. Monchakovskaya, A. Kubanov, M. Rakhmatulina, O. E. Kuznetsov, Darya А. Synkova, D. Verbenko","doi":"10.25208/vdv1408","DOIUrl":"https://doi.org/10.25208/vdv1408","url":null,"abstract":"Diffuse cutaneous leishmaniasis is a rare form of cutaneous leishmaniasis characterized by an inadequate immune response of the host cells to parasitic invasion (weak T-helper (Th)1 response or Th2 response with the production of interleukin (IL)-4 and IL-10). The characteristic features of the disease include diffuse nodular eruption, masquerading as leprosy and a frequent association with immunosuppression (HIV co-infection, for example). The Russian Federation is a non-endemic country for leishmaniasis, but this disease can be brought into the country by tourists, immigrants, refugees and military personnel. A clinical case of diffuse cutaneous leishmaniasis and HIV co-infection is presented. The patient was a citizen of Uzbekistan, a country endemic for leishmaniasis. The authors were unable to find domestic scientific publications describing cases of diffuse cutaneous leishmaniasis detected in the Russian Federation. The presented clinical case of diffuse cutaneous leishmaniasis in a patient with HIV is the first in the Russian literature.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46495788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Emelyanova, Aziz D. Zikirjahodzhaev, E. Saribekyan, E. Filonenko
Extramammary Paget's disease is a slow-growing cutaneous intraepithelial adenocarcinoma of the apocrine glands in the anogenital and axillary regions. The disease is extremely rare, affects predominantly postmenopausal women, and has nonspecific clinical caracteristics, so that it can take 2-10 years from the first clinical signs to diagnosis. The vulva and the perianal region are the most affected zones. Extramammary Pagets disease is clinically manifested as well-defined erythematous plaques with secondary changes, such as scaling, ulceration and even bleeding. Differential diagnosis is made between primary and secondary forms of Extramammary Pagets disease, candidiasis, contact dermatitis, Crohn's disease, eczema, erosive squamous lichen, purulent hydradenitis, Langerhans cell histiocytosis, sclerosing lichen, psoriasis, squamous cell carcinoma in situ, amelanocytic melanoma and mycosis fungoide. Treatment mainly includes the surgical component, as well as the use of photodynamic therapy, cytostatic agents, and, depending on the stage, systemic chemotherapy
{"title":"The current consensus for the diagnostic and treatment of extramammary Paget’s disease","authors":"O. Emelyanova, Aziz D. Zikirjahodzhaev, E. Saribekyan, E. Filonenko","doi":"10.25208/vdv1400","DOIUrl":"https://doi.org/10.25208/vdv1400","url":null,"abstract":"Extramammary Paget's disease is a slow-growing cutaneous intraepithelial adenocarcinoma of the apocrine glands in the anogenital and axillary regions. The disease is extremely rare, affects predominantly postmenopausal women, and has nonspecific clinical caracteristics, so that it can take 2-10 years from the first clinical signs to diagnosis. \u0000The vulva and the perianal region are the most affected zones. Extramammary Pagets disease is clinically manifested as well-defined erythematous plaques with secondary changes, such as scaling, ulceration and even bleeding. \u0000Differential diagnosis is made between primary and secondary forms of Extramammary Pagets disease, candidiasis, contact dermatitis, Crohn's disease, eczema, erosive squamous lichen, purulent hydradenitis, Langerhans cell histiocytosis, sclerosing lichen, psoriasis, squamous cell carcinoma in situ, amelanocytic melanoma and mycosis fungoide. \u0000Treatment mainly includes the surgical component, as well as the use of photodynamic therapy, cytostatic agents, and, depending on the stage, systemic chemotherapy","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41423728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In the structure of the incidence of skin tumors, melanoma accounts for a relatively smaller percentage, but that disease is associated with higher risk of an adverse outcome compared with many other malignancies. The study of innovative clinical developments in drug therapy for resectable melanoma, presented at the ASCO Annual Meeting - June 2022, is . The best clinical developments in drug treatment of patients with resectable melanoma were selected for analysis: 1) phase 3 study KEYNOTE-716; 2) PRADO; 3) Neo Trio; 4) SWOG 1512. The presented developments bring extremely promising results for melanoma therapy workflows. The use of cutting edge anti-cancer therapeutics acting on various molecular targets drastically improves the tumor response as well as straitens the total severity of treatment-related adverse events.
{"title":"Advancements in clinical developments in neo/adjuvant drug therapy for resectable melanoma: ASCO Annual Congress – June 2022","authors":"D. Andreev, A. Zavyalov","doi":"10.25208/vdv1382","DOIUrl":"https://doi.org/10.25208/vdv1382","url":null,"abstract":"In the structure of the incidence of skin tumors, melanoma accounts for a relatively smaller percentage, but that disease is associated with higher risk of an adverse outcome compared with many other malignancies. \u0000The study of innovative clinical developments in drug therapy for resectable melanoma, presented at the ASCO Annual Meeting - June 2022, is . \u0000The best clinical developments in drug treatment of patients with resectable melanoma were selected for analysis: 1) phase 3 study KEYNOTE-716; 2) PRADO; 3) Neo Trio; 4) SWOG 1512. The presented developments bring extremely promising results for melanoma therapy workflows. \u0000The use of cutting edge anti-cancer therapeutics acting on various molecular targets drastically improves the tumor response as well as straitens the total severity of treatment-related adverse events.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45515774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diana T. Kusraeva, O. Olisova, N. Teplyuk, O. Grabovskaya, L. Kayumova, Anna Bobkova, V. Varshavsky, L. F. Komleva, E.V. Petrenko, Ksenia Yu. Bobrova
Pyoderma gangrenosum is an autoinflammatory neutrophilic dermatosis. Diagnosis of the disease remains a difficult task to date, due to the lack of a gold standard of examination and differential diagnostic signs. The primary elements in the development of PG may be papules, pustules or bullae the dissection of which subsequently leads to the formation of ulcers with irregular, violaceous, undermined borders. In rare cases, the diagnosis of the disease can also be complicated by the rapid development of internal organs damage symptoms, which must be regarded as extracutaneous manifestations of PG. Extracutaneous lesions can occur before, during or after the appearance of skin rashes, and the detection of sterile neutrophil infiltrates in the defeat of internal organs confirm the concept of PG as a multisystemic disease. The presented case of a rare course of PG with multiple skin lesions and extracutaneous manifestations, simulating systemic vasculitis, emphasizes the importance of a detailed examination of patients in order to make a correct diagnosis and prescribe timely adequate treatment.
{"title":"PYODERMA GANGRENOSUM MIMICKING GRANULOMATOSIS WITH POLYANGIITIS: CACE REPORT AND RIVIEW OF THE LITERATURE","authors":"Diana T. Kusraeva, O. Olisova, N. Teplyuk, O. Grabovskaya, L. Kayumova, Anna Bobkova, V. Varshavsky, L. F. Komleva, E.V. Petrenko, Ksenia Yu. Bobrova","doi":"10.25208/vdv1386","DOIUrl":"https://doi.org/10.25208/vdv1386","url":null,"abstract":"Pyoderma gangrenosum is an autoinflammatory neutrophilic dermatosis. Diagnosis of the disease remains a difficult task to date, due to the lack of a gold standard of examination and differential diagnostic signs. The primary elements in the development of PG may be papules, pustules or bullae the dissection of which subsequently leads to the formation of ulcers with irregular, violaceous, undermined borders. In rare cases, the diagnosis of the disease can also be complicated by the rapid development of internal organs damage symptoms, which must be regarded as extracutaneous manifestations of PG. Extracutaneous lesions can occur before, during or after the appearance of skin rashes, and the detection of sterile neutrophil infiltrates in the defeat of internal organs confirm the concept of PG as a multisystemic disease. The presented case of a rare course of PG with multiple skin lesions and extracutaneous manifestations, simulating systemic vasculitis, emphasizes the importance of a detailed examination of patients in order to make a correct diagnosis and prescribe timely adequate treatment.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42518258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. V. Patrushev, A. V. Samtsov, K. O. Chepushtanova, T. Bogomolova, T. V. Bogdanova, A. Y. Alekssev, N. Vasilyeva
Background: currently,there is insufficient data on the antifungal activity of activated zinc pyrithione, which is widely used in practice. Taking into account the reports about a significant role ofMalasseziain the pathogenesis of a number of dermatoses, the study of this issue is of scientific, practical interest. Aims:to evaluate the antifungal activity of external forms of activated zinc pyrithione in the treatment of psoriasis, seborrheic dermatitis, pityriasis versicolor. Materials and methods:an open prospective study was conducted between March and July 2022. Patients with psoriasis, seborrheic dermatitis, pityriasis versicolor were treated with external forms of activated zinc pyrithione for 21 days. Skin scales and circular prints from lesion foci, as well as from skin areas without clinical manifestations before and after therapy were studied. A quantitative assessment of skin colonization by micromycetes of Malassezia was performed using microscopic, cultural methods of examination. Clinical efficacy and drug safety of the therapy was assessed using the Dermatological Symptom Scale Index, by recording adverse events at weeks 0, 1, 2, 3. Results:64 patients aged 18 to 65 years with diagnoses of psoriasis, seborrheic dermatitis, and pityriasis versicolor were included. 60 patients completed the study, 4 were excluded due to failure to adhere to the schedule. In patients with seborrheic dermatitis and pityriasis versicolor in the lesion foci after therapy, a significant decrease colonization level according to the results of microscopic, cultural studies was observed. In psoriasis patients, a significant decrease in the colonization level was obtained only based on the results of microscopic examination. In all groups, significant differences in comparison to the initial level were registered already at the 1st week of treatment. No adverse events were registered.
{"title":"A prospective open-label study of the antifungal activity of external forms of activated zinc pyrithione in the treatment of Malassezia-associated skin diseases","authors":"A. V. Patrushev, A. V. Samtsov, K. O. Chepushtanova, T. Bogomolova, T. V. Bogdanova, A. Y. Alekssev, N. Vasilyeva","doi":"10.25208/vdv1395","DOIUrl":"https://doi.org/10.25208/vdv1395","url":null,"abstract":"Background: currently,there is insufficient data on the antifungal activity of activated zinc pyrithione, which is widely used in practice. Taking into account the reports about a significant role ofMalasseziain the pathogenesis of a number of dermatoses, the study of this issue is of scientific, practical interest. \u0000Aims:to evaluate the antifungal activity of external forms of activated zinc pyrithione in the treatment of psoriasis, seborrheic dermatitis, pityriasis versicolor. \u0000Materials and methods:an open prospective study was conducted between March and July 2022. Patients with psoriasis, seborrheic dermatitis, pityriasis versicolor were treated with external forms of activated zinc pyrithione for 21 days. Skin scales and circular prints from lesion foci, as well as from skin areas without clinical manifestations before and after therapy were studied. A quantitative assessment of skin colonization by micromycetes of Malassezia was performed using microscopic, cultural methods of examination. Clinical efficacy and drug safety of the therapy was assessed using the Dermatological Symptom Scale Index, by recording adverse events at weeks 0, 1, 2, 3. \u0000Results:64 patients aged 18 to 65 years with diagnoses of psoriasis, seborrheic dermatitis, and pityriasis versicolor were included. 60 patients completed the study, 4 were excluded due to failure to adhere to the schedule. \u0000In patients with seborrheic dermatitis and pityriasis versicolor in the lesion foci after therapy, a significant decrease colonization level according to the results of microscopic, cultural studies was observed. In psoriasis patients, a significant decrease in the colonization level was obtained only based on the results of microscopic examination. \u0000In all groups, significant differences in comparison to the initial level were registered already at the 1st week of treatment. No adverse events were registered.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46422106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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