Background. Urogenital chlamydia infections is a widespread STI: 131 million people are infected every year. Scientists are studying the issue of reducing the sensitivity of the pathogen to traditionally used drugs and are investigating the effectiveness of antibacterial drugs active against C. trachomatis.
Aims: to study the efficacy and safety of the minocycline in the treatment of urogenital chlamydia infection in comparison with the doxycycline.
Methods: an open randomized comparative clinical trial included 100 patients: group 1 50 patients who received minocycline 100 mg 2 times a day for 7 days, group 2 50 patients who received doxycycline 100 mg 2 times a day in within 7 days. The diagnosis was confirmed by the detection of C. trachomatis by PCR. The parameter of the effectiveness of therapy was the eradication of C. trachomatis and the absence of clinical symptoms 4 weeks after therapy.
Results: 1 week after therapy, clinical symptoms were registered in 20;40.8% patients of group 1 and 28;57.1% patients of group 2 (p=0.106), 4 weeks later in 4;8.2% and 7;18.4% patients (p=0.524). In group 1, the absence of most subjective clinical symptoms was recorded in a shorter time than in the comparison group. 100% of patients had achieved eradication C. trachomatis, laboratory signs of an inflammatory reaction were recorded in 2;5.0% patients of group 1 and 3;7.3% patients of group 2 (p=1,000). According to the frequency of adverse drug events, there were also no significant differences between the groups, however, in group 2 patients, adverse drug events that had a high probability of being associated with taking the drug were recorded more often than in the group 1.
Conclusions. The results of the study demonstrated the comparable effectiveness of minocycline and doxycycline in the treatment of urogenital chlamydia infection and a similar safety profile of these drugs.
背景。泌尿生殖道衣原体感染是一种广泛存在的性传播感染:每年有1.31亿人感染。科学家们正在研究降低病原体对传统药物的敏感性的问题，并正在调查对沙眼衣原体有效的抗菌药物的有效性。目的:比较米诺环素与多西环素治疗泌尿生殖道衣原体感染的疗效和安全性;方法:采用开放随机对照临床试验，纳入100例患者:组150例患者给予米诺环素100mg / d 2次，连用7 d;组250例患者给予强力霉素100mg / d 2次，连用7 d。PCR检测沙眼衣原体，证实诊断。治疗效果的参数为治疗后4周沙眼衣原体的根除和临床症状的消失。
结果:治疗1周后，有20例患者出现临床症状，1组40.8%，28组57.1% (p=0.106)， 4周后有4例，8.2%，7例，18.4% (p=0.524)。在第一组中，大多数主观临床症状的消失时间比对照组短。100%的患者根除沙眼原体，2例患者有炎症反应的实验室征象，1组和3组为5.0%，2组为7.3% (p= 1000)。从药物不良事件发生频率来看，两组间也无显著差异，但2组患者记录的与服药相关的高概率药物不良事件发生率高于1组。
结论。研究结果表明米诺环素和多西环素在治疗泌尿生殖道衣原体感染方面具有相当的有效性，并且这些药物具有相似的安全性。
{"title":"Efficacy and safety profile of Minolexin in patients with urogenital chlamydia infection: results of an open randomized comparative clinical trial","authors":"Margarita Rakhmatulina","doi":"10.25208/vdv11877","DOIUrl":"https://doi.org/10.25208/vdv11877","url":null,"abstract":"Background. Urogenital chlamydia infections is a widespread STI: 131 million people are infected every year. Scientists are studying the issue of reducing the sensitivity of the pathogen to traditionally used drugs and are investigating the effectiveness of antibacterial drugs active against C. trachomatis.
 Aims: to study the efficacy and safety of the minocycline in the treatment of urogenital chlamydia infection in comparison with the doxycycline.
 Methods: an open randomized comparative clinical trial included 100 patients: group 1 50 patients who received minocycline 100 mg 2 times a day for 7 days, group 2 50 patients who received doxycycline 100 mg 2 times a day in within 7 days. The diagnosis was confirmed by the detection of C. trachomatis by PCR. The parameter of the effectiveness of therapy was the eradication of C. trachomatis and the absence of clinical symptoms 4 weeks after therapy.
 Results: 1 week after therapy, clinical symptoms were registered in 20;40.8% patients of group 1 and 28;57.1% patients of group 2 (p=0.106), 4 weeks later in 4;8.2% and 7;18.4% patients (p=0.524). In group 1, the absence of most subjective clinical symptoms was recorded in a shorter time than in the comparison group. 100% of patients had achieved eradication C. trachomatis, laboratory signs of an inflammatory reaction were recorded in 2;5.0% patients of group 1 and 3;7.3% patients of group 2 (p=1,000). According to the frequency of adverse drug events, there were also no significant differences between the groups, however, in group 2 patients, adverse drug events that had a high probability of being associated with taking the drug were recorded more often than in the group 1.
 Conclusions. The results of the study demonstrated the comparable effectiveness of minocycline and doxycycline in the treatment of urogenital chlamydia infection and a similar safety profile of these drugs.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":"361 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135734781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vulvovaginal candidiasis is a widespread infection caused by Candida. The disease affects 75-80% of women of reproductive age at least once during their lifetime, and 9-20% of them indicate the presence of three or more episodes of the disease during the year, which is classified as recurrent vulvovaginal candidiasis (RVVC). To date, the question of the causes of the formation of recurrent forms of the disease has not been definitively resolved, since RVVC is also observed in women who do not have known risk factors. Due to the fact that about 20-30% of patients with RVVC are healthy women without factors predisposing to its development, interindividual differences such as genetic predisposition and ethnicity, immune disorders, as well as the species diversity of Candida fungi and their antimycotic resistance may play a key role in the pathogenesis of idiopathic RVVC. In the literature review, the main etiopathogenetic mechanisms of the disease development are presented, the role of immune and genetic factors of predisposition to the development of recurrent vulvovaginal candidiasis is evaluated, changes in the species structure of the pathogen in recent years are analyzed. Modern approaches to the treatment of the disease are described, taking into account the indicators of antimycotic resistance, and the analysis of RVVC therapy regimens according to domestic and foreign clinical recommendations is carried out. The possibilities of using sertaconazole in the treatment of the disease are considered, the results of studies of its efficacy and safety in patients with vulvovaginal candidiasis are presented.
{"title":"Current state of the etiopathogenesis and the treatment of recurrent vulvovaginitis candidiasis","authors":"Margarita Rakhmatulina","doi":"10.25208/vdv11879","DOIUrl":"https://doi.org/10.25208/vdv11879","url":null,"abstract":"Vulvovaginal candidiasis is a widespread infection caused by Candida. The disease affects 75-80% of women of reproductive age at least once during their lifetime, and 9-20% of them indicate the presence of three or more episodes of the disease during the year, which is classified as recurrent vulvovaginal candidiasis (RVVC). To date, the question of the causes of the formation of recurrent forms of the disease has not been definitively resolved, since RVVC is also observed in women who do not have known risk factors. Due to the fact that about 20-30% of patients with RVVC are healthy women without factors predisposing to its development, interindividual differences such as genetic predisposition and ethnicity, immune disorders, as well as the species diversity of Candida fungi and their antimycotic resistance may play a key role in the pathogenesis of idiopathic RVVC. \u0000In the literature review, the main etiopathogenetic mechanisms of the disease development are presented, the role of immune and genetic factors of predisposition to the development of recurrent vulvovaginal candidiasis is evaluated, changes in the species structure of the pathogen in recent years are analyzed. Modern approaches to the treatment of the disease are described, taking into account the indicators of antimycotic resistance, and the analysis of RVVC therapy regimens according to domestic and foreign clinical recommendations is carried out. The possibilities of using sertaconazole in the treatment of the disease are considered, the results of studies of its efficacy and safety in patients with vulvovaginal candidiasis are presented.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42830075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Evgenia V. Okladnikova, Vladimir M. Merk, Yuriy А. Krivopalov, Vladimir A. Khorzhevskii, Tatiana Ruksha
Indeterminate dendritic cell tumor (IDCT) is rare histiocytic tumor characterized by the proliferation of indeterminate dendritic cells. It is more often diagnosed in middle-aged people, in approximately equal proportions in men and women. The etiology of IDCT is unknown. Differential diagnosis is carried out with other diseases that mimic IDCT and is important for determining treatment tactics. The present paper presents a clinical case of IDCT in a 48-year-old man. Using only the patient's complaints and examination data was not enough to diagnose the disease. The similarity of skin manifestations in IDCT with other skin pathologies requires an immunohistochemical study of the affected areas for CD1a, CD68, S100, Langerin expression evaluation as well as the presence of Birbeck's granules visulization. Routine histological examination does not sufficient for correct IDCT diagnostics.
{"title":"Indeterminate dendritic cell tumor (IDCT)","authors":"Evgenia V. Okladnikova, Vladimir M. Merk, Yuriy А. Krivopalov, Vladimir A. Khorzhevskii, Tatiana Ruksha","doi":"10.25208/vdv8137","DOIUrl":"https://doi.org/10.25208/vdv8137","url":null,"abstract":"Indeterminate dendritic cell tumor (IDCT) is rare histiocytic tumor characterized by the proliferation of indeterminate dendritic cells. It is more often diagnosed in middle-aged people, in approximately equal proportions in men and women. The etiology of IDCT is unknown. Differential diagnosis is carried out with other diseases that mimic IDCT and is important for determining treatment tactics. The present paper presents a clinical case of IDCT in a 48-year-old man. Using only the patient's complaints and examination data was not enough to diagnose the disease. The similarity of skin manifestations in IDCT with other skin pathologies requires an immunohistochemical study of the affected areas for CD1a, CD68, S100, Langerin expression evaluation as well as the presence of Birbeck's granules visulization. Routine histological examination does not sufficient for correct IDCT diagnostics.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49097529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The paper describes changes in resources and performance of medical organizations providing medical care in the field of dermatovenereology in 2016-2022. The dynamics of the main rates of the service was analyzed, and the rates achieved in 2022 were compared with those before the pandemic of a new coronavirus infection. The rates of the provision of the population of the Russian Federation with dermatovenereologists, 24-hour and daytime dermatovenereological beds are presented. The analysis of the volumes of dermatovenereologic medical care dynamics provided in outpatient, inpatient and day hospital conditions was carried out. The dynamics of the incidence of sexually transmitted infections, as well as the prevalence of diseases of the skin and subcutaneous tissue, is reflected.
{"title":"Resources and performance rates of medical organizations providing medical care in the field of dermatovenereology in the Russian Federation in 2016-2022","authors":"E. Bogdanova, A. Kubanov","doi":"10.25208/vdv12385","DOIUrl":"https://doi.org/10.25208/vdv12385","url":null,"abstract":"The paper describes changes in resources and performance of medical organizations providing medical care in the field of dermatovenereology in 2016-2022. The dynamics of the main rates of the service was analyzed, and the rates achieved in 2022 were compared with those before the pandemic of a new coronavirus infection. The rates of the provision of the population of the Russian Federation with dermatovenereologists, 24-hour and daytime dermatovenereological beds are presented. The analysis of the volumes of dermatovenereologic medical care dynamics provided in outpatient, inpatient and day hospital conditions was carried out. The dynamics of the incidence of sexually transmitted infections, as well as the prevalence of diseases of the skin and subcutaneous tissue, is reflected.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46283745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elena Yu. Novoselova, M. Rakhmatulina, A. Karamova
Aims: to assess the current state of the technical support of medical organizations of the dermatovenerological profile with equipment for phototherapy of dermatoses. Materials and methods: information about the availability of equipment for phototherapy of dermatosis and/or the need to purchase it, the intensity of use of the available equipment for various nosologies, as well as problems related to its service, obtained from 64 medical organizations of the dermatovenerological profile in 62 constituent entities of the Russian Federation. Results: 8 (12%) specialized medical organizations are currently not equipped with phototherapy equipment. In 56 medical organizations using phototherapy equipment, the share of foreign-made medical equipment is 84%. Of the 22 models of medical equipment, only 12 (54%) are included in the State Register of Medical Devices and have a valid registration certificate. 192 (75%) pieces of equipment of medical organizations are intended for local phototherapy in the medium-wave (UVB) or long-wave (UFA) ultraviolet radiation mode, and only 63 (25%) units are represented by ultraviolet cabins (57 UVA (PUVA) and UVB-311 cabins). and 6 UVA and UVB (SFT) booths). Out of 57 UV cabins, only 18 (32%) are simultaneously equipped with UVA and UVB-311 radiation sources. Half of the medical organizations of the dermatovenerological profile (50%) experience difficulties with servicing the installed devices, 43 (67%) medical organizations reported the need for equipment for phototherapy of dermatosis. Conclusions. Due to the instability of logistics and sanctions for the supply of medical equipment to the country, the development and registration of a medical device for phototherapy of dermatosis and T-cell lymphomas of the skin, and its further production in Russia, is relevant.
{"title":"Analysis of equipment for phototherapy in institutions of dermatovenerologic profile","authors":"Elena Yu. Novoselova, M. Rakhmatulina, A. Karamova","doi":"10.25208/vdv13730","DOIUrl":"https://doi.org/10.25208/vdv13730","url":null,"abstract":"Aims: to assess the current state of the technical support of medical organizations of the dermatovenerological profile with equipment for phototherapy of dermatoses. \u0000Materials and methods: information about the availability of equipment for phototherapy of dermatosis and/or the need to purchase it, the intensity of use of the available equipment for various nosologies, as well as problems related to its service, obtained from 64 medical organizations of the dermatovenerological profile in 62 constituent entities of the Russian Federation. \u0000Results: 8 (12%) specialized medical organizations are currently not equipped with phototherapy equipment. In 56 medical organizations using phototherapy equipment, the share of foreign-made medical equipment is 84%. Of the 22 models of medical equipment, only 12 (54%) are included in the State Register of Medical Devices and have a valid registration certificate. 192 (75%) pieces of equipment of medical organizations are intended for local phototherapy in the medium-wave (UVB) or long-wave (UFA) ultraviolet radiation mode, and only 63 (25%) units are represented by ultraviolet cabins (57 UVA (PUVA) and UVB-311 cabins). and 6 UVA and UVB (SFT) booths). Out of 57 UV cabins, only 18 (32%) are simultaneously equipped with UVA and UVB-311 radiation sources. Half of the medical organizations of the dermatovenerological profile (50%) experience difficulties with servicing the installed devices, 43 (67%) medical organizations reported the need for equipment for phototherapy of dermatosis. \u0000Conclusions. Due to the instability of logistics and sanctions for the supply of medical equipment to the country, the development and registration of a medical device for phototherapy of dermatosis and T-cell lymphomas of the skin, and its further production in Russia, is relevant.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45491639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The annual growth in the number of people living with HIV infection inevitably leads to an increase in the number of cases of any type of comorbidity. The article analyzes modern epidemiological, clinical, therapeutic aspects of anogenital herpes simplex virus infection (AHVI) in HIV-positive patients. Human immunodeficiency virus (HIV) and herpes simplex virus 2 (HSV-2) combine epidemiological and biological synergy. Concomitant anogenital herpes increases the risk of HIV infection by 2.7-4.7 times, and also contributes to its transmission through unprotected sexual intercourse. In HIV-infected patients with AHVI, the genital excretion of HSV-2 is increased. Among HIV-positive individuals, the seroprevalence of HSV-2 exceeds the population figures by 1.9-3.8 times. The incidence of AHVI in a cohort of Russians with a positive HIV status is 5-7.8 times higher than in the general population. The review demonstrates that both infections can have a negative mutual influence on the clinical course of each other. Particular emphasis is placed on the timely diagnosis of cases of coinfection. Based on the current regulatory documents, the authors developed and presented an algorithm for testing for HIV in patients with a newly diagnosed anogenital herpes.
{"title":"Anogenital herpesvirus infection: focus on HIV-positive patients","authors":"S. Prozherin, A. Podymova","doi":"10.25208/vdv7753","DOIUrl":"https://doi.org/10.25208/vdv7753","url":null,"abstract":"The annual growth in the number of people living with HIV infection inevitably leads to an increase in the number of cases of any type of comorbidity. The article analyzes modern epidemiological, clinical, therapeutic aspects of anogenital herpes simplex virus infection (AHVI) in HIV-positive patients. Human immunodeficiency virus (HIV) and herpes simplex virus 2 (HSV-2) combine epidemiological and biological synergy. Concomitant anogenital herpes increases the risk of HIV infection by 2.7-4.7 times, and also contributes to its transmission through unprotected sexual intercourse. In HIV-infected patients with AHVI, the genital excretion of HSV-2 is increased. Among HIV-positive individuals, the seroprevalence of HSV-2 exceeds the population figures by 1.9-3.8 times. The incidence of AHVI in a cohort of Russians with a positive HIV status is 5-7.8 times higher than in the general population. The review demonstrates that both infections can have a negative mutual influence on the clinical course of each other. Particular emphasis is placed on the timely diagnosis of cases of coinfection. Based on the current regulatory documents, the authors developed and presented an algorithm for testing for HIV in patients with a newly diagnosed anogenital herpes.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44662682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Krasnoselskikh, E. Sokolovskiy, M. Rakhmatulina, Elena Yu. Novoselova, L. Melekhina
The article is devoted to assessing the situation with syphilis and other sexually transmitted infections in the USSR and Russia in the period after the Second World War. On the basis of long-term statistical data, the patterns of rises and decreases in syphilis, gonorrhoea, chlamydia infection are analyzed, possible factors influencing the epidemic process are discussed and a comparative assessment of the current situation in Russia and Western countries is carried out. Comparing to the previous year, there was an increase of the syphilis incidence by 39.4% in 2021, by 33.7% in 2022 and by 14.7% in the first 4 months of 2023. The incidence of gonococcal infection increased by 10.4%, 10.0% and 5.5%, respectively. The attention is drawn to the negative trend of an increase of latent and late syphilis among other forms, as well as rising number of late neurosyphilis and late cardiovascular syphilis cases. In view of the predicted increase in the incidence of syphilis and other STIs in the coming years, the authors emphasize the urgent need to develop and implement a state interdisciplinary program aimed to epidemiological monitoring, improvement of the diagnosis and treatment, prevention of the dissemination of syphilis and other STIs and controlling of factors that negatively affect the reproductive health of the nation.
{"title":"Syphilis and some other STIs in the Russian Federation: past, present and ways to control of the epidemiological situation in the future","authors":"T. Krasnoselskikh, E. Sokolovskiy, M. Rakhmatulina, Elena Yu. Novoselova, L. Melekhina","doi":"10.25208/vdv13726","DOIUrl":"https://doi.org/10.25208/vdv13726","url":null,"abstract":"The article is devoted to assessing the situation with syphilis and other sexually transmitted infections in the USSR and Russia in the period after the Second World War. On the basis of long-term statistical data, the patterns of rises and decreases in syphilis, gonorrhoea, chlamydia infection are analyzed, possible factors influencing the epidemic process are discussed and a comparative assessment of the current situation in Russia and Western countries is carried out. Comparing to the previous year, there was an increase of the syphilis incidence by 39.4% in 2021, by 33.7% in 2022 and by 14.7% in the first 4 months of 2023. The incidence of gonococcal infection increased by 10.4%, 10.0% and 5.5%, respectively. The attention is drawn to the negative trend of an increase of latent and late syphilis among other forms, as well as rising number of late neurosyphilis and late cardiovascular syphilis cases. In view of the predicted increase in the incidence of syphilis and other STIs in the coming years, the authors emphasize the urgent need to develop and implement a state interdisciplinary program aimed to epidemiological monitoring, improvement of the diagnosis and treatment, prevention of the dissemination of syphilis and other STIs and controlling of factors that negatively affect the reproductive health of the nation.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44771870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Аlexey V. Samtsov is 70 years old","authors":"I. Belousova, A. Patrushev, Dmitry V. Chernyshov","doi":"10.25208/vdv14138","DOIUrl":"https://doi.org/10.25208/vdv14138","url":null,"abstract":"","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44940756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patients with acne often develop neuropsychiatric disorders of varying severity, correlating, as a rule, with the severity of dermatosis. Isotretinoin is the most commonly used drug for the treatment of moderate acne. Due to the fact that in a number of studies isotretinoin was considered as a trigger for the development of various neuropsychiatric disorders, numerous studies were conducted to prove this possibility or to refute it. An analysis of the literature showed that, according to the vast majority of studies, isotretinoin does not lead to neuropsychiatric disorders. However, given the opposite opinion of some authors, it is advisable to actively identify, including in the anamnesis, any psycho-emotional disorders, and monitor them during therapy. In these cases, it is indicated to start treatment with small doses (recommendations have not been developed). Considering that, according to some data, the severity of neuropsychiatric disorders is dose-dependent, it is advisable to prescribe isotretinoin - Lidoz
{"title":"To the question of the effect of isotretinoin on the neuropsychic state of patients with acne","authors":"A. Samtsov","doi":"10.25208/vdv1414","DOIUrl":"https://doi.org/10.25208/vdv1414","url":null,"abstract":"Patients with acne often develop neuropsychiatric disorders of varying severity, correlating, as a rule, with the severity of dermatosis. Isotretinoin is the most commonly used drug for the treatment of moderate acne. Due to the fact that in a number of studies isotretinoin was considered as a trigger for the development of various neuropsychiatric disorders, numerous studies were conducted to prove this possibility or to refute it. An analysis of the literature showed that, according to the vast majority of studies, isotretinoin does not lead to neuropsychiatric disorders. However, given the opposite opinion of some authors, it is advisable to actively identify, including in the anamnesis, any psycho-emotional disorders, and monitor them during therapy. In these cases, it is indicated to start treatment with small doses (recommendations have not been developed). Considering that, according to some data, the severity of neuropsychiatric disorders is dose-dependent, it is advisable to prescribe isotretinoin - Lidoz","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44354124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rosacea is a chronic inflammatory disease of the skin mainly of the central facial region, having gender and age correlations. Currently, more and more data is accumulating on the analysis of rosacea phenotypes, scientific discussions are underway on the feasibility of switching from subtype classification to phenotypic classification to justify individualized approaches to therapy. The phenotypic classification is based on the manifestations of rosacea and distinguishes diagnostic signs from the main and secondary symptoms. Thus, phymatous changes and persistent central facial erythema are the only diagnostic signs (criteria) of rosacea, and hyperemia, telangiectasia and inflammatory papules / pustules are the main symptoms and only in combination can indicate the diagnosis of rosacea. Secondary signs of rosacea are hot flashes, burning, pain, swelling and a feeling of dryness. The symptoms of rosacea are based on various pathophysiological mechanisms, so therapy in most cases will consist of a combination of topical agents with systemic drugs or physiotherapy. The article presents a clinical case of rosacea based on a phenotypic approach to therapy.
{"title":"DEMONSTRATION OF A CLINICAL CASE BASED ON THE PHENOTYPIC APPROACH OF ROSACEA THERAPY","authors":"M. Drozhdina, V. Bobro","doi":"10.25208/vdv1401","DOIUrl":"https://doi.org/10.25208/vdv1401","url":null,"abstract":"Rosacea is a chronic inflammatory disease of the skin mainly of the central facial region, having gender and age correlations. Currently, more and more data is accumulating on the analysis of rosacea phenotypes, scientific discussions are underway on the feasibility of switching from subtype classification to phenotypic classification to justify individualized approaches to therapy. The phenotypic classification is based on the manifestations of rosacea and distinguishes diagnostic signs from the main and secondary symptoms. Thus, phymatous changes and persistent central facial erythema are the only diagnostic signs (criteria) of rosacea, and hyperemia, telangiectasia and inflammatory papules / pustules are the main symptoms and only in combination can indicate the diagnosis of rosacea. Secondary signs of rosacea are hot flashes, burning, pain, swelling and a feeling of dryness. The symptoms of rosacea are based on various pathophysiological mechanisms, so therapy in most cases will consist of a combination of topical agents with systemic drugs or physiotherapy. The article presents a clinical case of rosacea based on a phenotypic approach to therapy.","PeriodicalId":23618,"journal":{"name":"Vestnik dermatologii i venerologii","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45082104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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