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2020 Advances in Science and Engineering Technology International Conferences (ASET)最新文献

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Method Development and Force Degradation Study for Daclatasvir Using LC-MS/MS 采用LC-MS/MS对Daclatasvir进行药效降解研究
Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118229
Hemlata M. Nimie, M. N. Deodhar
Daclatasvir (DCV) used for the treatment of chronic hepatitis C virus infection (HCV). The present piece of work contains development, validation and force degradation study for DCV has been carried out by using LC-MS/MS technique. The LC-MS system contains 4000 QTrap along with the Shimadzu LC 20AD LC System, controlled by Analyst 1.4.2 software for present study. For the preparation of standard drug DCV and its marketed formulations the diluent used was acetonitrile: water (50:50v/v). LC system runs with the conditions like use of C18 column (Thermo Scientific, 5µm, 4.6 X 250 mm size), column temperature 25°C (Ambient), Injection volume 2 µL, total run time 10 min, flow rate 0.5 mL/min and an isocratic mobile phase consist of 1mM Ammonium acetate Buffer pH=4 adjusted with 50% acetic acid in water as ‘A’ and acetonitrile as a solvent ‘B’ (20:80 v/v). Validation was carried out by testing parameters like LOD (limit of detection), LOQ (Limit of quantification) linearity, ruggedness, accuracy and precision in terms of reproducibility, repeatability according to ICH guidelines. The calibration range for DCV was 500 to 5000 ng/mL, where 800, 1600 & 3200 ng/mL concentrations of DCV set as an Internal QC with proper labeling. All Three QC samples applied n=6 times. For Mass spectrometry (MS) quantification of the DCV, the interest of mass m/z 740.50/514.10 was considered. The force degradation study has been carried out on LC-MS for DCV at different stress conditions. The drug was found to be stable in acidic, neutral, oxidative and photolytic but degrades in basic conditions. The proposed method is fast, economical, avoiding chemical steps and wet chemistry and thus provides a comparatively simpler, rapid green method for routine analysis in pharmaceutical industries.
Daclatasvir (DCV)用于治疗慢性丙型肝炎病毒感染(HCV)。本文采用LC-MS/MS技术对DCV进行了开发、验证和力退化研究。LC- ms系统包含4000 QTrap和岛津LC 20AD LC系统,本研究由Analyst 1.4.2软件控制。配制标准药物DCV及其市售制剂时,使用的稀释剂为乙腈:水(50:50v/v)。LC系统运行条件为:使用C18柱(Thermo Scientific, 5µm, 4.6 X 250 mm尺寸),柱温25°C (Ambient),进样量2µL,总运行时间10 min,流速0.5 mL/min,等速流动相为1mM醋酸铵缓冲液pH=4,以50%醋酸水溶液为' A ',乙腈为溶剂' B ' (20:80 v/v)。通过LOD(检出限)、LOQ(定量限)等检测参数进行验证,线性度、稳健性、准确度和精密度在再现性、可重复性方面符合ICH指南。DCV的校准范围为500至5000 ng/mL,其中800、1600和3200 ng/mL浓度的DCV设置为内部QC,并附有适当的标签。所有三个QC样品应用n=6次。质谱(MS)定量DCV时,考虑了质点m/z 740.50/514.10。采用LC-MS对DCV进行了不同应力条件下的力退化研究。该药物在酸性、中性、氧化和光解条件下均稳定,但在碱性条件下降解。该方法快速、经济,避免了化学步骤和湿化学,为制药行业的常规分析提供了一种相对简单、快速的绿色方法。
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引用次数: 1
Journey of Education Technology towards Innovation 教育科技走向创新之旅
Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118334
A. Ahmed, A. Moncey, Megha Mohan, Nikita Tresa Cyriac, Sahar Ali, S. Mariam, Mingxuan Lyu, Kamaladevi Baskaran
Technology has been growing constantly and has bought an impact on many different areas and fields most noticeably in the education sector. It has emerged as strong influencer in the teaching- learning process between tutors and students. Students are given an opportunity to learn and explore through technology. Education Technology facilitates learning and improving performance by creating, using and managing appropriate technological processes and resources. The purpose of this study is to understand the impact of Educational Technology journey towards innovation in UAE and to define the perception of three major players of the schooling sector - Teachers, Parents and Students. The questionnaire method of data collection was carried out in order to cover a greater number of respondents. The results indicate that while respondents are accommodating to the various benefits emerging from virtual classroom and increased employment of technology in the schooling system. They are also aware of the negative effects of technology and less appreciative of the continuous dependence of technology in the education system.
科技一直在不断发展,并对许多不同的领域和领域产生了影响,最明显的是教育部门。它在教师和学生之间的教与学过程中产生了强大的影响。学生有机会通过科技来学习和探索。教育技术通过创造、使用和管理适当的技术过程和资源,促进学习和提高成绩。本研究的目的是了解教育技术之旅对阿联酋创新的影响,并定义教育部门的三个主要参与者——教师、家长和学生的看法。为了覆盖更多的调查对象,采用问卷调查的方法收集数据。结果表明,虽然受访者正在适应虚拟教室和学校系统中技术就业增加所带来的各种好处。他们也意识到技术的负面影响,不太了解教育系统对技术的持续依赖。
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引用次数: 5
Nonlinear Optics of Photonic Crystals 光子晶体的非线性光学
Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118251
Y. Benachour
The “marriage” between photonic crystal structures and nonlinear optics is studied in the present paper. We demonstrate the considerable interest in the enhancement of nonlinear effects using photonic crystals (PCs). The Nano structuring of materials allows realizing the phase matching in photonic crystals. Phase tuning is achieved using the anomalous dispersion existing at the edges of photonic forbidden bands. This type of structure also makes it possible to obtain high densities of modes of the optical field at the frequency of the excitation wave, where it is desired to obtain significant nonlinear effects. An introduction and discussion of some of the basic principles of nonlinear and photonic crystals are given. The focus is on engineered of these PCs by using some total nonlinear materials or a mix with silica. With this “marriage”, it is then possible to realize, on a microscopic scale, different passive optical functions (filters, switches, tunable) or active functions (amplification, light emission, modulation, etc.).
本文研究了光子晶体结构与非线性光学之间的“联姻”。我们对利用光子晶体(PCs)增强非线性效应表现出相当大的兴趣。材料的纳米结构使光子晶体的相位匹配成为可能。相位调谐是利用存在于光子禁带边缘的反常色散来实现的。这种类型的结构也使得在激发波的频率上获得光场模式的高密度成为可能,在那里需要获得显著的非线性效应。对非线性和光子晶体的一些基本原理作了介绍和讨论。重点是通过使用一些全非线性材料或二氧化硅混合物来设计这些pc。有了这种“联姻”,就有可能在微观尺度上实现不同的无源光学功能(滤光片、开关、可调谐)或主动功能(放大、发光、调制等)。
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引用次数: 0
Fabrication of acoustic microfluidic platforms for particle manipulation 粒子操纵声学微流控平台的研制
Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118311
Abdullah Al-Ali, W. Waheed, E. Abu-Nada, A. Alazzam
In this paper, a detailed fabrication process of an acoustic microfluidic platform is discussed. The platform consists of a piezoelectric wafer with interdigitated electrode transducers embedded in it. The fabrication process involves micro-patterning the interdigitated transducers using chromium to create surface acoustic waves. The fabrication steps include surface preparation, sputtering, spin coating, lithography, and chemical etching. The paper also includes an experiment in which the fabricated device is tested. Polystyrene particles are suspended in deionized water at a concentration of one million particles per milliliter. A droplet of the solution is placed on the wafer and the response of particles to the surface acoustic wave is investigated using an inverted microscope.
本文详细讨论了声微流控平台的制作过程。该平台由压电晶片组成,其中嵌入了交错式电极换能器。制造过程包括使用铬对交叉换能器进行微图案化以产生表面声波。制造步骤包括表面制备、溅射、自旋镀膜、光刻和化学蚀刻。本文还包括一个实验,其中制作的装置进行了测试。聚苯乙烯颗粒悬浮在去离子水中,浓度为每毫升100万个颗粒。将溶液滴在晶圆上,用倒置显微镜研究了溶液对表面声波的响应。
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引用次数: 3
FEA of RC Columns Reinforced with WWF Subjected to Concentric Loading 同心荷载作用下钢筋混凝土柱的有限元分析
Pub Date : 2020-02-01 DOI: 10.1109/aset48392.2020.9118337
Muhammad Kyaure, Mutaman Elyas
This paper investigates the potential of using Welded Wire Fabric (WWF) as longitudinal and transverse reinforcement in concrete columns as an alternative to conventionally tied columns. Commercial software package ABAQUS was used to develop a nonlinear finite element (FE) model capable of accurately simulating the axial behavior of concrete columns reinforced with WWF. A parametric study was conducted with the aim of evaluating the effect of replacing both longitudinal & transverse reinforcement with WWF in short concrete columns with concrete compressive strength of 50 MPa. Each WWF reinforced column is compared with its equivalent conventionally reinforced column in terms of dimensions, reinforcement ratio and material properties. Results from the FE analysis revealed that replacing conventional reinforcement with WWF resulted in a slight increase in strength and appreciable enhancement of ductility without compromising stiffness. In conclusion, WWF is a sufficient form of reinforcement for short concrete columns subjected to concentric loading. WWF could potentially yield more ductility in columns with optimal reinforcement ratio (3%).
本文研究了使用焊接钢丝织物(WWF)作为混凝土柱纵向和横向钢筋的潜力,作为传统绑柱的替代方案。利用商业软件ABAQUS建立了能准确模拟浇筑混凝土柱轴向性能的非线性有限元模型。以抗压强度为50 MPa的混凝土短柱为研究对象,通过参数化研究,评价了用WWF代替纵向和横向配筋的效果。在尺寸、配筋率和材料性能方面,将每根WWF加固柱与其等效的常规加固柱进行比较。有限元分析的结果表明,用WWF代替传统的钢筋,在不影响刚度的情况下,强度略有增加,延性明显增强。总之,对于受同心荷载作用的短混凝土柱,WWF是一种足够的加固形式。在最佳配筋率(3%)下,WWF可能会使柱具有更大的延性。
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引用次数: 1
Density Functional Theory Studies of Vacancies in Penta-Graphene Nanoribbons 五石墨烯纳米带空位的密度泛函理论研究
Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118169
Khaldoun Tarawneh
We use the first principal pseudopotential calculations combined with the generalized gradient approximation to investigate the structural, magnetic and electronic properties of defective penta-graphene one dimensional monolayer. Our calculations predict that, the equilibrium geometrical structure with a single vacancy defect shows a substantial reconstruction of atomic positions. The magnetic and electronic properties of penta-graphene nanoribbons can be adjusted by single vacancy defect The electronic bandgap depends on the ribbon width as well as on the single vacancy location relative to the ribbon edge. The formation energy of a single vacancy in penta-graphene nanoribbon is found to be 8.4 eV in the central region of the ribbons and decreases to 7.1 eV when the vacancy location is closer to the ribbon edge. Our results for a stable penta-graphene nanoribbon with a controllable bandgap is promising for nanoelectronic devices
我们使用第一主赝势计算结合广义梯度近似研究了缺陷五石墨烯一维单层的结构、磁性和电子性质。我们的计算预测,具有单个空位缺陷的平衡几何结构显示出原子位置的实质性重建。单空位缺陷可以调节五石墨烯纳米带的磁性和电子性能,电子带隙取决于带的宽度以及相对于带边缘的单空位位置。在五石墨烯纳米带的中心区域,单个空位的形成能为8.4 eV,当空位位置靠近带边缘时,形成能降至7.1 eV。我们的研究结果表明,具有可控带隙的稳定五石墨烯纳米带在纳米电子器件中很有前景
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引用次数: 1
Quality-dependent adaptation in a swarm of drones for environmental monitoring 一群用于环境监测的无人机的质量依赖适应
Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118235
Giulia de Masi, E. Ferrante
Recently, individual or groups of drones have been used increasingly more frequently for applications in environmental monitoring. Groups of drones add larger robustness, lower vulnerability, higher accuracy and flexibility with respect to the use of single drones. These groups are called swarms when designed to make collective decisions trough local mutual interactions, as real social insects swarms. Natural environments are characterized by intrinsic dynamics that are hard to predict. Since a main issue faced by swarms of drones is the absence of adaptability to changes of the environment, in this paper we proposed a principled approach that can potentially be used to develop monitoring system based on drones swarm, able to adapt to changes of the environment thanks to the presence of stubborn individuals. Furthermore, we study how the level of consensus is affected by the interplay between the proportion of stubborn individuals and the difficulty of the problem, expressed by the ratio between the qualities of the different sites.
最近,单个或成群的无人机越来越频繁地用于环境监测。与使用单个无人机相比,无人机群增加了更大的稳健性,更低的脆弱性,更高的准确性和灵活性。当这些群体被设计成通过局部相互作用做出集体决策时,就像真正的群居昆虫群一样,它们被称为群体。自然环境具有难以预测的内在动态特征。由于无人机群面临的一个主要问题是缺乏对环境变化的适应性,在本文中,我们提出了一种原则性的方法,可以用于开发基于无人机群的监测系统,由于顽固个体的存在,能够适应环境的变化。此外,我们研究了共识水平如何受到顽固个体比例和问题难度之间的相互作用的影响,这是由不同站点质量之间的比率表示的。
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引用次数: 13
FE modeling of concerte beams reinforced in flexure using BFRP bars BFRP筋受弯混凝土梁的有限元模拟
Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118321
Haya H. Mhanna, Hakem Alkhraisha, F. Abed
This paper aim to investigate the flexural behavior of concrete beams reinforced longitudinally with Basalt Fiber Reinforced Polymer (BFRP) bars. Finite element (FE) modeling software, ABAQUS, is used to develop a nonlinear model capable of simulating the behavior of FRP reinforced beams in flexure. To validate the FE model, data extracted from ABAQUS were verified through a comparison with published experimental data. Through a parametric study, this paper aims to study the effect of varying the reinforcement ratio on the flexural behavior of BFRP reinforced beams. The reinforcement ratios studied are 0.003, 0.0047, 0.0068, and 0.0123. The paper also present comparative analysis among various FRP reinforcement bars. BFRP reinforced beam is compared with Glass Fiber Reinforced Polymer (GFRP) and Carbon Fiber Reinforced Polymer (CFRP) reinforced beams with similar reinforcement ratio. A third parametric study was conducted to evaluate the effect of varying the number of reinforcement bars while keeping the axial stiffness constant. The results showed an increasing trend of flexural capacity with the increase in reinforcement ratio. The results also indicated the much larger deflection resistance of the CFRP reinforced beams as compared to BFRP and GFRP beams. Lastly, varying the number of reinforcement bars had no effect on the strength of the beam but rather on the stiffness.
本文旨在研究玄武岩纤维增强聚合物(BFRP)钢筋纵向加固混凝土梁的抗弯性能。利用有限元(FE)建模软件ABAQUS建立了能够模拟FRP筋梁受弯行为的非线性模型。为了验证有限元模型,将ABAQUS中提取的数据与已发表的实验数据进行对比验证。通过参数化研究,研究了不同配筋率对BFRP加固梁受弯性能的影响。研究的配筋率分别为0.003、0.0047、0.0068和0.0123。并对各种FRP筋进行了对比分析。将BFRP加固梁与相似配筋率的玻璃纤维增强聚合物(GFRP)和碳纤维增强聚合物(CFRP)加固梁进行了比较。第三个参数研究是为了评估在保持轴向刚度不变的情况下改变钢筋数量的效果。结果表明,随着配筋率的增加,抗弯承载力有增大的趋势。结果还表明,CFRP加固梁的抗挠度比BFRP和GFRP梁大得多。最后,改变钢筋的数量对梁的强度没有影响,但对刚度有影响。
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引用次数: 0
An overview of friction stir welding of high-density polyethylene 高密度聚乙烯搅拌摩擦焊接技术综述
Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118183
S. Iftikhar, A. Mourad, J. Sheikh-Ahmad
Friction stir welding (FSW) and friction stir spot welding (FSSW) of thermoplastics is becoming popular because of its many industrial applications. This paper specifically reviews the experimental studies available on the FSW and FSSW of high density polyethylene (HDPE), as it is a high demand thermoplastic material used in many industrial applications. The effect of process parameters (tool rotational speed, traverse speed, plunge depth, etc.), tool material and geometry (profile and size), and medium conditions (open-air, submerged, heat-assisted, cooling-assisted, etc.) on the weld joint mechanical properties are discussed. These studies help with narrowing the ranges of all the parameters involved, to optimize welding conditions to achieve highest joint strength. ANOVA (analysis of variance)-based studies are also discussed which help in determining the relative significance of the parameters affecting the joint strength. The thermal behavior of the weld joints, through differential scanning calorimetry (DSC) studies, has also been discussed. Finally, a few recommendations for future studies are presented.
热塑性塑料的搅拌摩擦焊(FSW)和搅拌摩擦点焊(FSSW)由于其在工业上的广泛应用而越来越受到人们的欢迎。高密度聚乙烯(HDPE)是一种高要求的热塑性材料,在许多工业应用中都有应用,本文专门综述了高密度聚乙烯(HDPE)的FSW和FSSW的实验研究。讨论了工艺参数(刀具转速、横移速度、插入深度等)、刀具材料和几何形状(轮廓和尺寸)以及介质条件(露天、浸没、热辅助、冷辅助等)对焊缝力学性能的影响。这些研究有助于缩小所涉及的所有参数的范围,以优化焊接条件,以实现最高的接头强度。还讨论了基于方差分析的研究,这有助于确定影响关节强度的参数的相对重要性。通过差示扫描量热法(DSC)研究,还讨论了焊接接头的热行为。最后,对今后的研究提出了几点建议。
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引用次数: 10
Preparing for the smart cities: IoT enabled last-mile delivery 为智慧城市做准备:支持物联网的最后一英里交付
Pub Date : 2020-02-01 DOI: 10.1109/ASET48392.2020.9118197
Leena Wanganoo, Abhinandan H. Patil
UAE is among the fastest-growing e-commerce country in the Middle East, and this provides ample growth opportunity to the last mile parcel/courier delivery companies. Yet, the sector struggles to achieve its objective of providing exemplary customer satisfaction and minimizing the operating cost. This paper explores the challenges faced by the logistics companies engaged in the last mile delivery of e-commerce parcels. Firstly, in most countries of the Middle East including UAE there is” No descriptive delivery address “available, which means no postal codes or Zip codes of the final delivery point and secondly, most of the logistics provider still operate on legacy driven semi - digitized track & trace systems for the transportation and customer relation management. This leads to the poor last-mile delivery performance of the logistics provider ultimately impacting the e-commerce brand reputation. To increase efficiency, there is a need to embrace innovative technologies and integrate the supply chain key partners. Based on the exploratory study, we suggest a conceptual framework based on integrated technologies like GPS, IoT, and TMS which will provide the delivery operator with real-time visibility, reliability, and a smart last-mile solution. The unique three technology blend will provide full digitization of the core operations, seamless co-ordination with multiple sources, data-based decision making and real-time visibility.
阿联酋是中东地区电子商务发展最快的国家之一,这为最后一英里包裹/快递公司提供了充足的增长机会。然而,该行业正在努力实现其提供模范客户满意度和最小化运营成本的目标。本文探讨了从事电子商务包裹最后一公里配送的物流公司所面临的挑战。首先,在包括阿联酋在内的大多数中东国家,“没有描述性的交货地址”可用,这意味着没有最终交货点的邮政编码或邮政编码。其次,大多数物流供应商仍然使用传统驱动的半数字化跟踪和跟踪系统进行运输和客户关系管理。这导致物流供应商的最后一英里交付表现不佳,最终影响电子商务品牌的声誉。为了提高效率,有必要采用创新技术并整合供应链的主要合作伙伴。在探索性研究的基础上,我们提出了一个基于GPS、物联网和TMS等集成技术的概念框架,该框架将为配送运营商提供实时可见性、可靠性和智能最后一英里解决方案。独特的三种技术融合将提供核心业务的完全数字化,与多个来源的无缝协调,基于数据的决策和实时可见性。
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引用次数: 9
期刊
2020 Advances in Science and Engineering Technology International Conferences (ASET)
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