Acta Biomaterialia最新文献

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Corrigendum to “Synergizing autophagic cell death and oxaliplatin-induced immunogenic death by a self-delivery micelle for enhanced tumor immunotherapy” [Acta Biomaterialia, 190, 2024, 548-559]

IF 9.4 1区医学 Q1 ENGINEERING, BIOMEDICAL

Acta Biomaterialia

Pub Date : 2025-04-01 DOI: 10.1016/j.actbio.2025.02.062

Tao Deng , Dong Chen , Fang Chen , Chaoqun Xu , Qiang Zhang , Min Li , Yashi Wang , Zhidi He , Man Li , Qin He

引用次数: 0

Oxygen/siRNA-carrying fluoro-nanosensitizers for radio-immunotherapy sensitization

IF 9.4 1区医学 Q1 ENGINEERING, BIOMEDICAL

Acta Biomaterialia

Pub Date : 2025-04-01 DOI: 10.1016/j.actbio.2025.03.011

Fan Wu , Yu Qian , Chenglong Ge , Yang Zhou , Jing Yan , Xudong Li , Xun Liu , Yuheng Lei , Ziyin Zhao , Yuansong Wei , Junliang Zhu , Lichen Yin , Shanzhou Duan

The anti-tumor efficacy of radiotherapy (RT) is limited by the hypoxic and immunosuppressive tumor microenvironment (TME), which leads to RT resistance and failure in eradicating distant metastatic lesions. Herein, we developed a fluorinated nanosensitizer that could deliver both oxygen (O₂) and ADAR1 siRNA into tumor cells to reinforce RT by alleviating hypoxia and immunosuppression. Fluorinated poly(β-amino ester) (fPBAE) was designed to complex ADAR1 siRNA (siADAR1) via electrostatic attraction and load O₂ due to the O₂-dissolving capacity of fluoroalkyls. The formed nanocomplexes (NCs) facilitated robust cytosolic delivery into cancer cells after intratumoral injection, enabling efficient ADAR1 silencing to promote IFN-β release and enhance DC maturation and T cell infiltration. At the meantime, O₂ was released to alleviate tumoral hypoxia. As thus, NCs significantly enhanced the anti-tumor efficacy of RT and when further coupled with programmed death ligand-1 antibody, they effectively restrained the growth of both treated primary tumors and untreated distant tumors by eliciting robust systemic immune response. This study therefore reports an enlightened strategy for remodeling the immunosuppressive TME and sensitizing radio-immunotherapy.

Statement of significance

The hypoxic and immunosuppressive tumor microenvironment (TME) greatly limits the anti-tumor efficacy of radiotherapy (RT). To address this critical issue, a nano-sensitizer based on fluorinated poly(β-amino ester) (fPBAE) is herein developed to mediate efficient co-delivery of oxygen (O₂) and ADAR1 siRNA into tumor cells. ADAR1 silencing promotes DC maturation and T cell infiltration to reverse immunosuppression while the released O₂ alleviates hypoxia to sensitize RT. Thus, the nano-sensitizer remarkably enhances the anti-tumor efficacy of RT and elicits robust systemic immune response to eradicate primary and distant tumors when further coupled with PD-L1 antibody. This study provides a promising approach for RT sensitization and radio-immunotherapy.

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引用次数: 0

Spontaneous bone regeneration achieved through one-step alignment of human mesenchymal stem cell-embedded collagen

IF 9.4 1区医学 Q1 ENGINEERING, BIOMEDICAL

Acta Biomaterialia

Pub Date : 2025-04-01 DOI: 10.1016/j.actbio.2025.03.007

Cheol Ho Heo , Ki Baek Yeo , Minjung Chae , Seon Young Bak , Hyeon Jin Choi , Sohyeon Jeong , Nakwon Choi , Seung-Kyun Kang , Sang Ho Jun , Myoung-Ryul Ok , So Yeon Kim

Optimizing cell-matrix interactions for effective bone regeneration remains a significant hurdle in tissue engineering. This study presents a novel approach by developing a human mesenchymal stem cells (hMSCs)-embedded 3D aligned collagen for enhanced bone regeneration. A one-step mechanical strain was applied to a mixture of hMSCs and collagen, producing an hMSC-embedded, aligned 3D collagen hydrogel patch that mimics the natural bone matrix. Notably, the hMSCs embedded in the aligned collagen spontaneously differentiated into osteoblasts without external inducing reagents. Immunofluorescence analysis revealed that the BMP2-smad1/5 signaling pathway, critical for osteogenic differentiation, were activated by aligned collagen. In vivo experiments using a calvarial defect model confirmed that this approach effectively promotes new bone formation, starting centrally within the defect rather than from the edges adjacent to the existing bone. Our findings suggest that this simple method of pre-straining to create aligned 3D collagen embedded with hMSCs holds promise as a novel cell therapy platform for bone regeneration.

Statement of Significance

This study introduces a novel method for enhancing bone regeneration by developing a 3D aligned collagen patch embedded with hMSCs. A single mechanical strain applied to the hMSC-collagen mixture produces an aligned collagen matrix that mimics natural bone tissue. Remarkably, the hMSCs spontaneously differentiate into osteoblasts in the absence of exogenous inducing reagents triggered by activation of the bone morphogenetic protein signaling pathway. In vivo studies using a calvarial defect model confirm effective bone regeneration, initiating the new bone generation from the center of the defect. This approach offers a promising and simple cell therapy platform for bone repair, with broad implications for tissue engineering and regenerative medicine.

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引用次数: 0

Corrigendum to “Controllable release of nitric oxide and doxorubicin from engineered nanospheres for synergistic tumor therapy” [Acta Biomaterialia 57, 2017, 498-510]

IF 9.4 1区医学 Q1 ENGINEERING, BIOMEDICAL

Acta Biomaterialia

Pub Date : 2025-04-01 DOI: 10.1016/j.actbio.2025.01.063

Lianjiang Tan , Ran Huang , Xiaoqiang Li , Shuiping Liu , Yu-Mei Shen

引用次数: 0

Corrigendum to “Mechanically tough, adhesive, self-healing hydrogel promotes annulus fibrosus repair via autologous cell recruitment and microenvironment regulation” [Acta Biomaterialia, 2024, 178, 50-67]

IF 9.4 1区医学 Q1 ENGINEERING, BIOMEDICAL

Acta Biomaterialia

Pub Date : 2025-04-01 DOI: 10.1016/j.actbio.2025.03.008

Zhenyuan Wei , Han Ye , Yucai Li , Xiaoxiao Li , Yi Liu , Yujie Chen , Jiangming Yu , Jielin Wang , Xiaojian Ye

引用次数: 0

Corrigendum to “Heterogeneous Cu2O-SnO2 doped polydopamine fenton-like nanoenzymes for synergetic photothermal-chemodynamic antibacterial application” [Acta Biomaterialia 173, 2024, 420–431]

IF 9.4 1区医学 Q1 ENGINEERING, BIOMEDICAL

Acta Biomaterialia

Pub Date : 2025-04-01 DOI: 10.1016/j.actbio.2025.01.064

Jingpi Gao , Yangyang Yan , Shegan Gao , Heying Li , Xiantao Lin , Ji Cheng , Yan Hu , Kaiyong Cai , Xiaozhi Zhang , Jinghua Li

引用次数: 0

Corrigendum to “Deoxygenated hydroxyapatite inhibits macrophage inflammation through fibronectin restricted adsorption” [Acta Biomaterialia, 2025, 191, 177–188]

IF 9.4 1区医学 Q1 ENGINEERING, BIOMEDICAL

Acta Biomaterialia

Pub Date : 2025-04-01 DOI: 10.1016/j.actbio.2025.02.044

Jingxuan Zhou , Fanyu Zhang , Qinchao Tang , Taomin Zhu , Yueqi Ni , Qian Wu , Qunli Liu , Runlin Zhu , Tianman Wang , Yufeng Zhang , Xiaoxin Zhang , Hong He

引用次数: 0

Characterization and classification of platelet-rich plasma in biomaterial research

IF 9.4 1区医学 Q1 ENGINEERING, BIOMEDICAL

Acta Biomaterialia

Pub Date : 2025-04-01 DOI: 10.1016/j.actbio.2025.02.040

Khan Sharun , S. Amitha Banu

引用次数: 0

Multifunctional porous organic polymer-based hybrid nanoparticles for sonodynamically enhanced cuproptosis and synergistic tumor therapy

IF 9.4 1区医学 Q1 ENGINEERING, BIOMEDICAL

Acta Biomaterialia

Pub Date : 2025-04-01 DOI: 10.1016/j.actbio.2025.02.045

Meiting Li , Zhuoyin Liu , Dan Peng , Yadong Liu , Lili Cheng , Baizhu Chen , Jie Liu

Cuproptosis has gained significant attention among different cell death pathways in cancer therapy, which relies on the excessive accumulation of Cu²⁺ in mitochondria of tumor cells. Nevertheless, the high levels of glutathione in tumor microenvironment chelates with Cu²⁺ and thereby reducing its cytotoxicity. In this study, we designed core-shell porous organic polymers (POPs) nanoparticles to deliver and accumulate Cu²⁺ in tumor cells for enhanced cuproptosis. The porous organic polymers, containing bipyridine structural units, were synthesized on the aminated silica template, followed by the coordination of Cu²⁺ and the loading of artesunate (ART) as the sonosensitizer, yielding the Cu/ART@Hpy nanoparticles. In the acidic tumor microenvironment, the nanoparticles realized pH-responsive release of Cu²⁺. Meanwhile, the generation of ROS under ultrasound irradiation depleted intracellular glutathione, leading to the increased intracellular accumulation of Cu²⁺ for cuproptosis and triggering multiple cell death mechanisms for sonodynamically enhanced tumor therapy. Our study highlights the potential of the porous organic polymer as a platform for cuproptosis and synergistic tumor therapy.

Statement of significance

Cuproptosis is induced by the excessive accumulation of Cu²⁺ within the mitochondria of tumor cells. However, the high level of glutathione in the tumor microenvironment can chelate Cu²⁺, thereby reducing the therapeutic efficacy. In this study, we developed the core-shell structured Cu/ART@Hpy nanoparticles for pH-responsive delivery of Cu²⁺. Under ultrasound irradiation, the generated reactive oxygen species deplete intracellular glutathione, enhancing Cu²⁺ accumulation for cuproptosis and activating multiple cell death pathways. The Cu/ART@Hpy nanoparticles enable sonodynamically enhanced cuproptosis, achieving synergistic tumor therapy.

{"title":"Multifunctional porous organic polymer-based hybrid nanoparticles for sonodynamically enhanced cuproptosis and synergistic tumor therapy","authors":"Meiting Li , Zhuoyin Liu , Dan Peng , Yadong Liu , Lili Cheng , Baizhu Chen , Jie Liu","doi":"10.1016/j.actbio.2025.02.045","DOIUrl":"10.1016/j.actbio.2025.02.045","url":null,"abstract":"<div><div>Cuproptosis has gained significant attention among different cell death pathways in cancer therapy, which relies on the excessive accumulation of Cu<sup>2+</sup> in mitochondria of tumor cells. Nevertheless, the high levels of glutathione in tumor microenvironment chelates with Cu<sup>2+</sup> and thereby reducing its cytotoxicity. In this study, we designed core-shell porous organic polymers (POPs) nanoparticles to deliver and accumulate Cu<sup>2+</sup> in tumor cells for enhanced cuproptosis. The porous organic polymers, containing bipyridine structural units, were synthesized on the aminated silica template, followed by the coordination of Cu<sup>2+</sup> and the loading of artesunate (ART) as the sonosensitizer, yielding the Cu/ART@Hpy nanoparticles. In the acidic tumor microenvironment, the nanoparticles realized pH-responsive release of Cu<sup>2+</sup>. Meanwhile, the generation of ROS under ultrasound irradiation depleted intracellular glutathione, leading to the increased intracellular accumulation of Cu<sup>2+</sup> for cuproptosis and triggering multiple cell death mechanisms for sonodynamically enhanced tumor therapy. Our study highlights the potential of the porous organic polymer as a platform for cuproptosis and synergistic tumor therapy.</div></div><div><h3>Statement of significance</h3><div>Cuproptosis is induced by the excessive accumulation of Cu²⁺ within the mitochondria of tumor cells. However, the high level of glutathione in the tumor microenvironment can chelate Cu²⁺, thereby reducing the therapeutic efficacy. In this study, we developed the core-shell structured Cu/ART@Hpy nanoparticles for pH-responsive delivery of Cu²⁺. Under ultrasound irradiation, the generated reactive oxygen species deplete intracellular glutathione, enhancing Cu²⁺ accumulation for cuproptosis and activating multiple cell death pathways. The Cu/ART@Hpy nanoparticles enable sonodynamically enhanced cuproptosis, achieving synergistic tumor therapy.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 350-363"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical properties of fresh rhesus monkey brain tissue

IF 9.4 1区医学 Q1 ENGINEERING, BIOMEDICAL

Acta Biomaterialia

Pub Date : 2025-04-01 DOI: 10.1016/j.actbio.2025.02.049

Grace M. Jeanpierre , Manuel K. Rausch , Samantha R. Santacruz

Studying brain tissue mechanics is critical for understanding how the brain's physical properties influence its biological functions. Non-human primates, such as rhesus monkeys, are a key translational model for human neuroscience research, yet their brain tissue mechanics remain poorly understood. We report the mechanical properties of rhesus monkey white (corona radiata, CR) and gray (basal ganglia, BG) matter during compression relaxation, tension relaxation, tension-compression cycling (strain = 0.15, n_CR = 21, n_BG = 14), and shear cycling (strain = 0.3, n_CR = 17, n_BG = 9). Compression relaxation yields short and long-term time constants of 1.13 ± 0.041 s and 26.3 ± 0.68 s for CR and 1.22 ± 0.046 s and 28.3 ± 0.70 s for BG. Tension relaxation yields short and long-term time constants of 1.10 ± 0.052 s and 28.2 ± 0.82 s for CR and 1.19 ± 0.052 s and 29 ± 1.3 s for BG. Tension-compression cycling yields elastic moduli (E₁, E₂, E₃) of 36 ± 3.8 kPa, 0.61 ± 0.096 kPa, and 9.3 ± 0.90 kPa for CR and 27 ± 4.8 kPa, 0.68 ± 0.092 kPa, and 8 ± 1.0 kPa for BG. Shear cycling yields E₁, E₂, and E₃ of 3.9 ± 0.77 kPa, 0.19 ± 0.034 kPa, and 3.1 ± 0.40 kPa for CR and 2.8 ± 0.52 kPa, 0.18 ± 0.058 kPa, and 3.2 ± 0.53 kPa for BG. Hysteresis areas are also captured during tension-compression and shear cycling. These findings extend the translatability of rhesus monkey models for neuroscience.

Statement of Significance

While rhesus monkeys are a valuable translational model in human neuroscience research, there is a huge gap in knowledge about rhesus monkey brain tissue mechanics. This study serves to increase our understanding of rhesus monkey brain tissue mechanics and is the first to report the stiffness, time constant, and hysteresis parameters for rhesus monkey brain tissue in compression, tension, and shear for both the corona radiata and basal ganglia. The data is available in an open-source format, allowing others to fit and validate their mechanical models.

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