Acta Biomaterialia最新文献

{"title":"Corrigendum to “Sprayable hydrogel dressing accelerates wound healing with combined reactive oxygen species-scavenging and antibacterial abilities” [Acta Biomaterialia 124, 2021, 219-232]","authors":"Hao Cheng , Zhe Shi , Kan Yue , Xusheng Huang , Yichuan Xu , Chenghao Gao , Zhongqi Yao , Yu Shrike Zhang , Jian Wang","doi":"10.1016/j.actbio.2026.02.001","DOIUrl":"10.1016/j.actbio.2026.02.001","url":null,"abstract":"","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"212 ","pages":"Pages 873-874"},"PeriodicalIF":9.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146196085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial transfer through tunneling nanotubes inspires an innovative strategy for intercellular drug delivery","authors":"Yitian Du ,&nbsp;Yiwei Peng ,&nbsp;Yiliang Yang ,&nbsp;Zhenzhen Yang ,&nbsp;Datong Gao ,&nbsp;Jiajia Li ,&nbsp;Meng Lin ,&nbsp;Xianrong Qi","doi":"10.1016/j.actbio.2025.12.048","DOIUrl":"10.1016/j.actbio.2025.12.048","url":null,"abstract":"<div><div>The efficacy of drug delivery, particularly for solid tumors, is severely hampered by a cascade of biological barriers—including dense extracellular matrix, high interstitial fluid pressure, and inefficient vascularization—that limit therapeutic penetration and distribution. Biological materials, such as cells, extracellular vesicles and organelles, serve as biocompatibility and targeted delivery vehicles, offering significant therapeutic potential. However, most current strategies emphasize multifunctional and biomimetic delivery systems designed to traverse the extracellular stroma, often overlooking intracellular transport pathways. Here, we demonstrate that mitochondria and their hitchhiked cargos are transported via tunneling nanotubes (TNTs), contiguous cytoplasmic bridges that interconnect cells. Oxidative stress plays a pivotal role in stimulating both TNTs formation and mitochondrial transfer. By leveraging TNTs as an intracellular highway, we achieved intercellular transport and deep tissue penetration of the photosensitizer IR780, which was hitchhiked onto mitochondria (designated as IR780/Mito). The intensity of near-infrared (NIR) light governs TNTs dynamics, either promoting formation or inducing cleavage, by modulating oxidative stress levels generated upon IR780 excitation. Under mild NIR irradiation, moderate oxidative stress enhances TNTs formation and facilitates IR780/Mito transfer, enabling efficient delivery directly into tumor cells. Conversely, intense NIR irradiation triggers excessive reactive oxygen species (ROS) production, leading to TNT disruption and subsequent blockade of IR780/Mito transport. These findings present emerging opportunities for exploration into the use of TNTs transshipment channel to realize controllable intracellular transport of different types of cargos, with broad and promising applications in the diagnosis and treatment of multiple diseases in the future.</div></div><div><h3>Statement of significance</h3><div>This work presents a new strategy for delivering drugs deep into tumors by hijacking the body’s own cellular “highways”—tunneling nanotubes (TNTs). Instead of designing synthetic nanoparticles, we load drugs directly onto mitochondria, the cell’s energy units, which naturally travel between cells via TNTs. Using a safe near‑infrared light, we can precisely turn this delivery route on or off by controlling the level of cellular stress: mild light promotes transport, while strong light shuts it down. This approach leverages natural cell‑to‑cell communication to overcome physical barriers in solid tumors, offering a smart, biocompatible platform for improving precision cancer therapy and treating other diseases involving intercellular signaling.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"212 ","pages":"Pages 671-684"},"PeriodicalIF":9.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145859143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avenues for optimization of cardiac therapeutics by minimally invasive delivery","authors":"Yuan Li ,&nbsp;Philippe Menasché ,&nbsp;Gordana Vunjak-Novakovic ,&nbsp;Ke Cheng","doi":"10.1016/j.actbio.2026.01.033","DOIUrl":"10.1016/j.actbio.2026.01.033","url":null,"abstract":"<div><div>In the past 20 years, minimally invasive delivery strategies have emerged to bridge the therapeutic gap between highly invasive surgery and less efficient nonsurgical approaches. New, less invasive technologies, including vascular, transendocardial, thoracoscopic, and inhalation delivery methods, can enhance cardiac targeting, promote drug retention, and minimize trauma compared to conventional interventions. Understanding current therapeutic agents, including biomolecules, biomaterials, and medical devices, along with their respective mechanisms, is essential for optimizing minimally invasive delivery strategies. Despite current therapeutic promises, dynamic heart motion and low delivery efficiency hinder the clinical translation of minimally invasive heart repair. Future studies should aim to address these hurdles by optimizing cardiac uptake, advancing personalized medicine, and developing safer delivery tools. To map the state of the field and its future potential, this review summarizes several minimally invasive cardiac delivery approaches and how to leverage existing techniques in concert to harness the impact of minimally invasive cardiac delivery.</div></div><div><h3>Statement of significance</h3><div>Minimally invasive cardiac delivery techniques represent an important advancement in treating heart diseases, bridging the gap between invasive surgeries and less effective nonsurgical methods. Unlike traditional approaches, these novel methods, including vascular, transendocardial, thoracoscopic, and inhalation techniques, provide targeted drug delivery directly to the heart while reducing trauma. This review uniquely synthesizes current advancements in delivering therapeutic agents such as biomolecules and medical devices, highlighting their improved cardiac targeting and retention capabilities. It identifies critical challenges, including the heart’s motion and low delivery efficiency, and discusses opportunities for innovation. Addressing these challenges can significantly impact patient outcomes, enhance personalized treatments, and advance the broader field of minimally invasive cardiovascular medicine.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"212 ","pages":"Pages 1-17"},"PeriodicalIF":9.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145999925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The internal composite design of autorotating plant wings","authors":"Ofer Braunshtein ,&nbsp;Zeneve Ezra ,&nbsp;Alex Koyfman ,&nbsp;Benny Bar-On","doi":"10.1016/j.actbio.2026.01.042","DOIUrl":"10.1016/j.actbio.2026.01.042","url":null,"abstract":"<div><div>To facilitate their dispersion, the miniature wing elements of autorotating winged fruits (samaras) must resist considerable multidirectional flight loadings as they fall from the tree and are carried away by occasional winds. However, the structural–mechanical properties of the samara wing, which stem from its internal composite design and provide it with resistance to deformations, are as yet unexplored. Here, we used structural analyses, composite-material modeling, and finite-element simulations to investigate the structure–mechanics–function relationship in the internal composite design of the samara of the <em>Tipuana tipu</em> tree. We show that the planar orientation of locally parallel fiber arrays varies globally throughout the wing, yielding a thin-layer composite element in which distinct functional regions resist multi-type mechanical deformations. This wing design provides extreme resistance to deformations at non-conventional orientations that are not aligned with the geometrical axes of the wing. The composite design principles of the samara wing can be incorporated into synthetic analogs to develop advanced, bioinspired minuscule wing elements that can effectively resist multidirectional loadings.</div></div><div><h3>Statement of significance</h3><div>The internal composite structure of autorotating plant wings (samaras) exhibits a natural design solution for paper-thin flight elements unfamiliar in conventional engineering frameworks. The orientation of the basic composite unit of the wing varies throughout the wing, thereby forming distinct functional regions with designated deformation-resistance capabilities. Adapting these design principles into simplified models promotes the engineering of ultra-small flight elements for minute aerial units.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"212 ","pages":"Pages 527-534"},"PeriodicalIF":9.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146044221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhaled biomimetic nanoparticles enhance pulmonary delivery of tetrandrine and pirfenidone for the treatment of idiopathic pulmonary fibrosis","authors":"Xinrui Zhang ,&nbsp;Ruibing Yu ,&nbsp;Xusheng Duan ,&nbsp;Tenghan Zhang ,&nbsp;Fanyu Cheng ,&nbsp;Shan Pan ,&nbsp;Dongfang Zhou ,&nbsp;Juhong Zhu ,&nbsp;Yue Cai ,&nbsp;Xuanrong Sun","doi":"10.1016/j.actbio.2025.12.038","DOIUrl":"10.1016/j.actbio.2025.12.038","url":null,"abstract":"<div><div>Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease marked by epithelial-mesenchymal transition (EMT) and overactivation of the transforming growth factor-β (TGF-β) signaling pathway, leading to collagen accumulation and macrophage infiltration in the lungs. Here, a bioinspired inhalable nanoplatform (PCMΦ@PPT) was designed and prepared for delivering therapy agents by penetrating the excessive physiological barrier deposited in the lesions and reversing established fibrotic foci in IPF. The nanoplatform was composed of two components: a pirfenidone (PFD) and tetrandrine (TET) co-loaded poly(lactic-co-glycolic acid) (PLGA) core (PPT), as well as a collagen-binding peptide and collagenase functionalized macrophage membrane (PCMΦ) shell. Following inhalation, PCMΦ@PPT has been shown to possess the capacity to target and penetrate the dense collagen barrier with the assistance of functional groups present on PCMΦ. The coating of PCMΦ enables PCMΦ@PPT to evade phagocytosis by macrophages that accumulate at the site of lesions. Meanwhile, the precise co-delivery of PFD and TET to the lesion site not only blocks the TGF-β signaling pathway but also promotes the recovery of damaged autophagy in fibroblasts, thereby alleviating the progression of IPF and partially improved lung function parameters of mice. In summary, this study proposes a novel nano-inhalation formulation for the treatment of IPF.</div></div><div><h3>Statement of significance</h3><div>The biomimetic nanoparticle PCMΦ@PPT was designed to recognize and degrade overexpressed extracellular matrix proteins. It is composed of two components: a poly(lactic-co-glycolic acid) core co-loaded with pirfenidone (PFD) and tetrandrine (TET), as well as a collagen-binding peptide and collagenase-functionalized macrophage membrane shell (PCMΦ). Following inhalation, PCMΦ@PPT has been shown to target and penetrate the dense collagen barrier while evading phagocytosis by macrophages, promoting drug retention in the focus. Finally, co-delivery of PFD and TET blocks the TGF-β signaling pathway, promoting recovery of damaged autophagy in fibroblasts and alleviating IPF progression and restoring lung function.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"212 ","pages":"Pages 613-623"},"PeriodicalIF":9.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapidly dissolving biomaterials for high-efficiency viral transduction","authors":"Christopher Moody ,&nbsp;Pritha Agarwalla ,&nbsp;Micah Mallory ,&nbsp;Nidhi Rane ,&nbsp;Treyvon W. Davis ,&nbsp;Israt Jahan Tulip ,&nbsp;Sharda Pandit ,&nbsp;Yevgeny Brudno","doi":"10.1016/j.actbio.2025.12.047","DOIUrl":"10.1016/j.actbio.2025.12.047","url":null,"abstract":"<div><div>Cell and gene therapy represent the frontier of genetic medicine for treating devastating diseases, yet they continue to face a critical bottleneck: inefficient genetic cell modification. While viral vectors remain our most powerful genetic delivery tools, their application suffers from significant transport insufficiencies with most viral particles wasted before reaching their cell targets. This fundamental challenge undermines the efficiency, safety, and economic viability of these potentially transformative therapies. Current transduction enhancers provide only partial solutions with significant drawbacks. RetroNectin works only with retroviruses and hematopoietic cells, spinoculation is time consuming and laborious, while polycationic polymers like polybrene pose toxicity concerns that preclude clinical applications. In this report, we introduce DUCTS (<strong>D</strong>issolving <strong>U</strong>ltrafast <strong>C</strong>ell <strong>T</strong>ransduction <strong>S</strong>ponges<strong>)</strong>, a transduction enhancer based on uncrosslinked alginate cryogels that works within five minutes and completely dissolves, enabling rapid and easy workflows. DUCTS demonstrates broad versatility, boosting cell transduction across a variety of viral vectors (gamma retrovirus, lentivirus, and adeno-associated virus) in both suspension and adherent cells. Notably, DUCTS achieves comparable transduction efficiency while reducing viral concentration requirements by an order of magnitude compared to standard protocols. This cell- and virus-agnostic platform streamlines gene transfer procedures, reduces viral consumption and associated costs, and enhances the accessibility and scalability of cell and gene therapies.</div></div><div><h3>Statement of significance</h3><div>In this report, we present DUCTS (<strong>D</strong>issolving <strong>U</strong>ltrafast <strong>C</strong>ell <strong>T</strong>ransduction <strong>S</strong>ponges<strong>)</strong>, a major advance to improve transduction technology, addressing critical bottlenecks in cell therapy manufacturing. Unlike existing methods that require lengthy procedures, specialized equipment, or toxic additives, DUCTS achieves comparable transduction efficiency in just five minutes using a simple, dissolving alginate sponge. This platform works across multiple virus types (lentivirus, retrovirus, AAV) and cell types, dramatically reducing viral vector requirements by 10-fold while maintaining cell viability. A modified DUCTs can also simultaneously activate and transduce T cells in a single step to revolutionize CAR-T cell manufacturing. With exceptional shelf stability and GMP-compatible materials, DUCTS offers a practical solution to reduce costs, accelerate production timelines, and enhance accessibility of life-saving cell therapies for patients worldwide.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"212 ","pages":"Pages 685-694"},"PeriodicalIF":9.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commensal microflora coating endows implants with biofilm-repellent, immunomodulatory and osteogenic properties","authors":"Muhammad Imran Rahim ,&nbsp;Shehneela Baseer ,&nbsp;Daniela Paasch ,&nbsp;Matthias Steglich ,&nbsp;Syed Fakhar H. Waqas ,&nbsp;Nico Lachmann ,&nbsp;Christine S. Falk ,&nbsp;Meike Stiesch","doi":"10.1016/j.actbio.2026.01.017","DOIUrl":"10.1016/j.actbio.2026.01.017","url":null,"abstract":"<div><div>Bacteria often form biofilms on biomaterials, and these biomaterial-associated infections then become highly resistant to antibiotics and the host immune system. Biofilm-driven implant failures underscore the urgent need for surface modifications that can concurrently prevent microbial colonization, modulate immune responses, and stimulate bone formation. Considering the competitive and osteo-immunomodulatory properties of commensal microflora, we developed Commensal Hybrid Materials (CHMs) by heat-anchoring multilayer assemblies of beneficial microbes onto titanium surfaces. A firmly adherent, carbon- and phosphorus-rich coating with micro-roughness and near-hydrophobic wettability (θ≈90°) suppressed <em>Porphyromonas gingivalis</em> biofilm formation on implant surfaces ‒ even after human-saliva conditioning. The coating did not release antimicrobial agents or alter bacterial gene expression, thereby avoiding selective pressure for antimicrobial resistance. The coated surfaces were cytocompatible with murine cells, did not elicit an inflammatory response, and skewed macrophages toward an M1-like phenotype with increased reactive oxygen species (ROS) production. Furthermore, CHMs first induced macrophages toward a balanced immune response by promoting pro-inflammatory M1 polarization with elevated <em>TNF-α</em> for infection control, followed by an <em>IL-10</em>–rich anti-inflammatory M2 phenotype that supports tissue repair. This polarization significantly upregulated expression of the osteoinductive factor oncostatin M (<em>OSM</em>), and conditioned media from CHM-stimulated macrophages upregulated type I collagen (<em>Col1</em>) expression in osteoblasts. Coated surfaces supported osteogenic potential in osteoblasts by increasing alkaline phosphatase activity and matrix mineralization. Although forthcoming <em>in vivo</em> studies will further validate performance, these findings position commensal microflora as a single, drug-free coating that integrates biofilm resistance, pro-host immune modulation, and osteogenic support to improve long-term implant outcomes.</div></div><div><h3>Statement of Significance</h3><div>Biomaterial-associated infections resist antibiotics and evade host immunity. We engineered commensal hybrid materials (CHMs) by heat-anchoring commensal microflora onto titanium, yielding a drug-free coating that repels biofilms without releasing antimicrobials or perturbing pathogen gene expression, thereby limiting resistance pressure. CHMs modulate macrophages‒eliciting an early M1/TNF-α phenotype for pathogen control followed by an IL-10–rich M2 phase that restores homeostasis. They also increase macrophage oncostatin M (OSM) and enhance osteoblast alkaline phosphatase activity and mineralization, promoting osteogenesis. By uniting biofilm resistance, immune modulation, and osteogenic support on a single surface, CHMs offer a promising route to extend implant longevity in orthopaedics and dentistry.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"212 ","pages":"Pages 266-280"},"PeriodicalIF":9.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Using a degradable three-layer sandwich-type coating to prevent titanium implant infection with the combined efficient bactericidal ability and fast immune remodeling property” [Acta Biomaterialia 154 (2022) 650-666]","authors":"Qiang Lian ,&nbsp;Shaowei Zheng ,&nbsp;Zhe Shi ,&nbsp;Kangxian Li ,&nbsp;Rong Chen ,&nbsp;Pinkai Wang ,&nbsp;Haibing Liu ,&nbsp;Yuhang Chen ,&nbsp;Qiang Zhong ,&nbsp;Qi Liu ,&nbsp;Xin Pan ,&nbsp;Jian Gao ,&nbsp;Chenghao Gao ,&nbsp;Weilu Liu ,&nbsp;Xuanpin Wu ,&nbsp;Yayun Zhang ,&nbsp;Yang Zhang ,&nbsp;Jian Wang ,&nbsp;Hao Cheng","doi":"10.1016/j.actbio.2025.12.022","DOIUrl":"10.1016/j.actbio.2025.12.022","url":null,"abstract":"","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"212 ","pages":"Pages 864-865"},"PeriodicalIF":9.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A natural corneal extracellular matrix-inspired dual-crosslinked hydrogel bioadhesive for emergency corneal trauma repair","authors":"Xiongfeng Nie ,&nbsp;Jingwen Hui ,&nbsp;Zheya Han ,&nbsp;Hongying Wang ,&nbsp;Yuejun Zhou ,&nbsp;Jiaxing Shao ,&nbsp;Leying Wang ,&nbsp;Ziyang Xu ,&nbsp;Bin Wu ,&nbsp;Chunyan Cui ,&nbsp;Quanhong Han ,&nbsp;Wenguang Liu","doi":"10.1016/j.actbio.2026.01.034","DOIUrl":"10.1016/j.actbio.2026.01.034","url":null,"abstract":"<div><div>Emergency corneal injuries necessitate immediate intervention to minimize the risk of infection and maintain optical clarity. However, corneal transplantation is unsuitable due to donor shortage and surgical complexity. Inspired by the synergistic role of collagen and glycosaminoglycans in the natural cornea extracellular matrix, a visible light-initiated, <em>in situ</em> dual-crosslinked hydrogel bioadhesive (GelMA-CSMA-NHS) is prepared by combining gelatin methacryloyl (GelMA) and N-hydroxysuccinimide-modified chondroitin sulfate methacrylate (CSMA-NHS). Upon exposure to 405 nm light, the bioadhesive precursor rapidly forms a hydrogel within 3 min directly on the injured cornea. It establishes strong interfacial integration with the tissue through topological entanglement and NHS-amine covalent crosslinking, thereby serving as a suture-free alternative for corneal repair. The dual-crosslinking mechanism significantly enhances the mechanical cohesion of the hydrogel, which synergistically improves its adhesive performance. The resulting hydrogel demonstrates high transparency, stable swelling behavior, good biocompatibility and biodegradability, and high burst pressure resistance. Using established models of partial stromal defects and full-thickness corneal lacerations, the bioadhesive integration and pro-healing effects of the hydrogel were evaluated. The results showed that the hydrogel bioadhesive rapidly seals corneal wounds, promotes re-epithelialization, reduces scarring formation, and supports full-thickness corneal regeneration.</div></div><div><h3>Statement of significance</h3><div>To address the limitations of traditional surgical sutures in treating acute corneal injuries, we developed a hydrogel bioadhesive (GelMA-CSMA-NHS). Inspired by the composition of the natural corneal extracellular matrix, the adhesive is fabricated from two derivatives of natural bioactive macromolecules. It can be rapidly crosslinked <em>in situ</em> on the injured cornea under visible light initiation via a dual-crosslinking mechanism, forming a strong adhesive interface with the tissue through topological entanglement and NHS-amine covalent bonding. In terms of performance, the hydrogel bioadhesive exhibits high transparency, good biocompatibility and biodegradability, and high burst pressure resistance. The hydrogel was evaluated in two models of acute corneal injury—partial stromal defects and full-thickness corneal lacerations. It accelerates re-epithelialization, minimizes scarring formation, and supports full-thickness corneal regeneration. Thus, this hydrogel bioadhesive shows considerable potential for emergency corneal repair and regenerative medicine.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"212 ","pages":"Pages 216-234"},"PeriodicalIF":9.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146004919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoring antitumor immunity by reprogramming abnormal lipid metabolism in the tumor microenvironment using irisin-manganese co-loaded nanoparticles","authors":"Xingzhe Tang ,&nbsp;Yufei Zhao ,&nbsp;Yan Gu ,&nbsp;Min Chen ,&nbsp;Jingyue Dai ,&nbsp;Yang Jiang ,&nbsp;Yuqing Lan ,&nbsp;Ying Cui ,&nbsp;Lin Fu ,&nbsp;Xinxiang Li ,&nbsp;Hui Mao ,&nbsp;Zhaogang Teng ,&nbsp;Xin-Gui Peng","doi":"10.1016/j.actbio.2026.01.011","DOIUrl":"10.1016/j.actbio.2026.01.011","url":null,"abstract":"<div><div>Targeting dysregulated lipid metabolism within the tumor microenvironment (TME) has emerged as a promising strategy for restoring anti-tumor immunity and reversing immune suppression to improve therapeutic efficiency. This study reports a nanomaterial platform for co-delivery of irisin and manganese ions (Mn²⁺) to exert cumulative effects of modulating lipid metabolism dysregulation and ameliorating the immunosuppressive TME in triple-negative breast cancer (TNBC). Irisin stimulates lipolysis and inhibits lipogenesis, whereas Mn²⁺ strengthen irisin binding to integrin αVβ5 over-expressed in various cancers. Developed manganese-containing mesoporous organosilica nanoparticles (MMONs) loaded with irisin (MMONs-irisin) were stable in physiological conditions but enabled pH responsive release of irisin and glutathione (GSH) responsive release of Mn²⁺ within the TME in a murine model of TNBC. Together, irisin and Mn²⁺ effectively reduced intracellular lipid droplets (LDs) across different cell types <em>in vitro</em> as well as intratumoral LDs in TME, thereby reprogramming dysregulated lipid metabolism and subsequently enhancing the antigen presentation in dendritic cells (DCs) and antigen-specific cytotoxicity of CD8⁺ T cells. Concomitantly, MMONs-irisin significantly increased immunogenicity of TNBC, involving activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway following depletion of LDs. Together, MMONs-irisin effectively delivers a coordinated cascade of immune-potentiating effects to disrupt immunosuppressive TME and restore anti-tumoral immunity, significantly improving the treatment responses of anti-programmed cell death protein 1 (aPD-1).</div></div><div><h3>Statement of significance</h3><div>Dysregulated lipid metabolism in the tumor microenvironment suppresses antitumor immunity. However, existing lipid-targeting strategies remain confined to specific cell types and are limited by systemic toxicity. To address this challenge, we developed irisin-manganese co-loaded nanoparticles that reprogram abnormal lipid metabolism in triple-negative breast cancer. This intervention restores tumor cell immunogenicity, dendritic cell antigen presentation, and CD8⁺ T cell cytotoxicity, thereby augmenting antitumor immune responses and potentiating the efficacy of anti-PD-1 therapy. These findings underscore a biomaterial-based strategy to overcome metabolic immune suppression and enhance cancer immunotherapy.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"212 ","pages":"Pages 786-801"},"PeriodicalIF":9.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145949420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}