Acta Biomaterialia最新文献

{"title":"CaGA nanozymes inhibit oxidative stress and protect mitochondrial function in ulcerative colitis therapy","authors":"Liting Lin ,&nbsp;Qingrong Li ,&nbsp;Yan Yang ,&nbsp;Cong Zhang ,&nbsp;Wenqi Wang ,&nbsp;Fan Ni ,&nbsp;Xianwen Wang","doi":"10.1016/j.actbio.2025.03.003","DOIUrl":"10.1016/j.actbio.2025.03.003","url":null,"abstract":"<div><div>Ulcerative colitis (UC) is a long-term inflammatory bowel disease characterized by intense inflammation of the colorectal mucosa. Overproduction of reactive oxygen species exacerbates the progression of UC, which is linked to mitochondrial impairment and dysbiosis of the intestinal microbiota. CaGA nanozymes have demonstrated efficacy in the treatment of UC. The modulation of M1 and M2 polarization of macrophages by CaGA nanozymes has been demonstrated to be useful in reducing inflammation. Furthermore, CaGA nanozymes regulate the M1 and M2 polarization of macrophages, efficiently decreasing inflammation. The oral delivery of CaGA nanozymes resulted in their enrichment in inflamed areas of the colon and effectively reduced colonic damage in mice with DSS-induced colitis by improving the repair of the intestinal barrier. An investigation of 16S rDNA sequencing revealed that CaGA nanozymes regulate populations of both pathogenic and helpful bacteria and impact the progression of ulcerative colitis by influencing the tricarboxylic acid (TCA) cycle. Thus, CaGA nanozymes may be employed in the management of ulcerative colitis to control the intestinal milieu and improve the preservation of the intestinal barrier by decreasing the invasion of inflammatory cells and restoring mitochondrial activity.</div></div><div><h3>Statement of significance</h3><div>CaGA nanozymes exhibit multifunctional enzymatic activity, effectively eliminating cellular RONS with robust antioxidant capacity. CaGA nanoenzymes promote macrophage M1 to M2 polarization and produce anti-inflammatory effects. CaGA nanozymes increase cell viability by restoring impaired mitochondrial function, reducing reactive oxygen species (ROS) production, and restoring the ability of mitochondria to produce ATP. CaGA nanozymes modulate intestinal flora diversity and composition, potentially influencing inflammatory pathways via aromatic compound metabolism. They participate in cellular energy and biosynthesis, regulating ulcerative colitis (UC)-related intestinal function through the tricarboxylic acid (TCA) and urea cycles. Calcium ions bind to GA nanomedicine and small particles are readily absorbed by inflammatory cells, preventing diarrhea from being rapidly excreted.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 380-398"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-scale additive manufacturing of 3D porous networks integrated with hydrogel for sustained in vitro tissue growth","authors":"J. Li,&nbsp;A. Isaakidou,&nbsp;L.J. van Zanten,&nbsp;R.P. Tas,&nbsp;M.J. Mirzaali,&nbsp;L.E. Fratila-Apachitei,&nbsp;A.A. Zadpoor","doi":"10.1016/j.actbio.2025.03.005","DOIUrl":"10.1016/j.actbio.2025.03.005","url":null,"abstract":"<div><div>The development of high-fidelity three-dimensional (3D) tissue models can minimize the need for animal models in clinical medicine and drug development. However, physical limitations regarding the distances within which diffusion processes are effective impose limitations on the size of such constructs. That is because larger-size constructs experience necrosis, especially in their centers, due to the cells residing deep inside such constructs not receiving enough oxygen and nutrients. This hampers the sustained <em>in vitro</em> growth of the tissues which is required for achieving functional microtissues. To address this challenge, we used three types of 3D printing technologies to create perfusable networks at different length scales and integrate them into such constructs. Toward this aim, networks incorporating porous conduits with increasingly complex configurations were designed and fabricated using fused deposition modeling, stereolithography, and two-photon polymerization while optimizing the printing conditions for each of these technologies. Furthermore, following network embedding in hydrogels, contrast agent-enhanced micro-computed tomography and confocal fluorescence microscopy were employed to characterize one of the essential network functionalities, namely the diffusion function. The investigations revealed the effects of various design parameters on the diffusion behavior of the porous conduits over 24 h. We found that the number of pores exerts the most significant influence on the diffusion behavior of the contrast agent, followed by variations in the pore size and hydrogel concentration. The analytical approach and the findings of this study establish a solid base for a new technological platform to fabricate perfusable multiscale 3D porous networks with complex designs while enabling the customization of diffusion characteristics to meet specific requirements for sustained <em>in vitro</em> tissue growth.</div></div><div><h3>Statement of significance</h3><div>This study addresses an essential limitation of current 3D tissue engineering, namely, sustaining tissue viability in larger constructs through optimized nutrient and oxygen delivery. By utilizing advanced 3D printing techniques this research proposes the fabrication of perfusable, multiscale and customizable networks that enhance diffusion and enable cell access to essential nutrients throughout the construct. The findings highlighted the role of network characteristics on the diffusion of a model compound within a hydrogel matrix. This work represents a promising technological platform for creating advanced <em>in vitro</em> 3D tissue models that can reduce the use of animal models in research involving tissue regeneration, disease models and drug development.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 198-212"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overcoming matrix barriers for enhanced immune infiltration using siRNA-coated metal-organic frameworks","authors":"Cheng Zeng ,&nbsp;Xiaojing Chen ,&nbsp;Mingxi Lin ,&nbsp;Yizi Jin ,&nbsp;Qing Guo ,&nbsp;Teng Zhou ,&nbsp;Xingang Wang ,&nbsp;Yiping Li ,&nbsp;Xinghui Wang ,&nbsp;Yongming Han ,&nbsp;Ling Du ,&nbsp;Qianyun Tang ,&nbsp;Peifeng Liu ,&nbsp;Jian Zhang","doi":"10.1016/j.actbio.2025.03.001","DOIUrl":"10.1016/j.actbio.2025.03.001","url":null,"abstract":"<div><div>The extracellular matrix (ECM) of solid tumor constitutes a formidable physical barrier that impedes immune cell infiltration, contributing to immunotherapy resistance. Breast cancer, particularly triple-negative breast cancer (TNBC), is characterized by a collagen-rich tumor microenvironment, which is associated with T cell exclusion and poor therapeutic outcomes. Discoidin domain receptor 2 (DDR2) and integrins, key ECM regulatory receptors on cancer cells, play pivotal role in maintaining this barrier. In this study, we developed a dual-receptor-targeted strategy using metal-organic frameworks (MOFs) to deliver DDR2-specific siRNA (siDDR2) and ITGAV-specific siRNA (siITGAV) to disrupt the ECM barrier. siDDR2 modulates immune infiltration by regulating collagen–cell interactions, while siITGAV suppresses TGF-β1 activation. The MOF@siDDR2+siITGAV complex significantly reduced collagen deposition, enhanced CD8+ <em>T</em> cell infiltration, and downregulated programmed cell death ligand 1 (PD-L1) expression in TNBC. Consequently, this approach markedly inhibited tumor growth. Our findings demonstrate that dual-receptor-targeted MOF-based nanocarriers (MOF@siDDR2+siITGAV) can effectively reprogram the tumor ECM to enhance immune cell access, offering a promising prospect for synergistic cancer immunotherapy.</div></div><div><h3>Statement of significance</h3><div>A dual-receptor-targeted MOF nanocarrier is developed to improve immune accessibility in tumors. Concurrent blockade of DDR2 and ITGAV effectively decreases collagen deposition, increases CD8+ <em>T</em> cell infiltration, and suppresses PD-L1 expression. Modulating the mechanical properties of the extracellular matrix (ECM) to enhance immune accessibility offers an innovative strategy for cancer treatment.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 410-422"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Donor-Acceptor-Donor small molecules for fluorescence/photoacoustic imaging and integrated photothermal therapy” [Acta Biomaterialia 2023, 164, 588-603]","authors":"Chang Wang ,&nbsp;Fang Wang ,&nbsp;Wentao Zou ,&nbsp;Yawei Miao ,&nbsp;Yaowei Zhu ,&nbsp;Mengyu Cao ,&nbsp;Bing Yu ,&nbsp;Hailin Cong ,&nbsp;Youqing Shen","doi":"10.1016/j.actbio.2025.02.019","DOIUrl":"10.1016/j.actbio.2025.02.019","url":null,"abstract":"","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 544-547"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory and antibacterial hydrogel based on a polymerizable ionic liquid","authors":"J.A. Romero-Antolín ,&nbsp;N. Gómez-Cerezo ,&nbsp;M. Manzano ,&nbsp;J.L. Pablos ,&nbsp;M. Vallet-Regí","doi":"10.1016/j.actbio.2025.03.015","DOIUrl":"10.1016/j.actbio.2025.03.015","url":null,"abstract":"<div><div>In the present era, the treatment of skin-infected wounds and their associated inflammation constitutes a significant challenge. These infections have the potential to impede the healing process and become a life-threatening pathology, particularly due to the rise of bacterial resistance. Hydrogels could successfully address this issue due to their unique capabilities and versatility. Among them, natural polymer-based hydrogels are especially advantageous as they resemble the extracellular matrix (ECM) and mechanical properties of natural tissues. In this study, we propose a dual-action hydrogel composed of methacrylated gelatin as a matrix and a salicylate (Sal) anion-exchanged polymerizable ionic liquid (PIL) to achieve anti-inflammatory and antibacterial activities. This material facilitated cell attachment and colonization with mouse endothelial fibroblasts. A flow cytometry assay was conducted to evaluate the anti-inflammatory effect, and demonstrated the differentiation of mouse macrophages to an M2 (reparative) phenotype. Therefore, the levels of TNF-α, interleukin-6 (IL-6), and interleukin (IL-10) were quantified to further evaluate this effect, demonstrating an inhibition on the pro-inflammatory ones. The inherent antibacterial capacity of the PIL was demonstrated against <em>Staphylococcus aureus</em> and <em>Escherichia coli</em>, thereby corroborating its potential as a wound dressing. To the best of our knowledge, this is the first reported hydrogel incorporating an anion-exchanged polymerizable ionic liquid that is capable of promoting macrophage differentiation into a reparative phenotype, of reducing pro-inflammatory cytokines, and of simultaneously retaining antibacterial activity. These features open the gate to the potential application of this hydrogel as a wound dressing.</div></div><div><h3>Statement of significance</h3><div>Bacterial wound infections may lead to severe problems due to their associate tissue inflammation and the emergence of bacterial resistance. In this sense, local therapies such as hydrogels have gathered much attention as alternative therapies for these pathologies. In this work, we have developed a natural polymer-based hydrogel copolymerized with a polymerizable ionic liquid containing salicylate as an anion. The hydrogel was shown to be biocompatible, and promoted macrophage differentiation to a reparative phenotype, while reducing the levels of pro-inflammatory cytokines. Finally, the high antibacterial capability against both gram-positive and gram-negative bacteria makes it a promising candidate for use in wound dressings.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 78-92"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Development of a multifunctional nano-hydroxyapatite platform (nHEA) for advanced treatment of severely infected full-thickness skin wounds” [Acta Biomaterialia, 181, 2024, 440-452]","authors":"Shixin Zhang ,&nbsp;Tinghan He ,&nbsp;Fengxin Zhao ,&nbsp;Qinling Tan ,&nbsp;Dongxiao Li ,&nbsp;Qiguang Wang ,&nbsp;Yumei Xiao ,&nbsp;Xingdong Zhang","doi":"10.1016/j.actbio.2025.01.058","DOIUrl":"10.1016/j.actbio.2025.01.058","url":null,"abstract":"","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 533-536"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Janus micro/nanomotors for enhanced disease treatment through their deep penetration capability","authors":"Haoran Ma,&nbsp;Yuxuan Guo,&nbsp;Xia Xu,&nbsp;Lei Ye,&nbsp;Yuanyuan Cheng,&nbsp;Xiaoxiao Wang","doi":"10.1016/j.actbio.2025.02.055","DOIUrl":"10.1016/j.actbio.2025.02.055","url":null,"abstract":"<div><div>Nanotherapeutic systems have provided an innovative means for the treatment of a wide range of diseases in modern medicine. However, the limited penetration of nanoparticles into focal tissues still greatly hampered their clinical application. With their unique two-sided structure and superior motility, Janus micro/nanomotors are expected to significantly improve the penetration of nanocarriers into organisms, thereby enhancing the therapeutic effects of diseases. This review introduces Janus micro/nanomotors with different morphologies and focuses on their propulsion mechanisms, including chemical field–driven, external physical field–driven, biologically–driven, and hybrid–driven mechanisms. We explore the research progress of Janus micro/nanomotors in various disease treatment areas (including cancer, cardiovascular diseases, neurological diseases, bacterial/fungal infections, and chronic inflammatory diseases) and elucidate the implementation strategies of Janus micro/nanomotors in facilitating disease therapies. Finally, we discuss the biosafety and biocompatibility of Janus micro/nanomotor, while exploring current challenges and opportunities in the field. We look forward to the Janus micro/nanomotor therapeutic platform demonstrating surprising therapeutic effects in the clinical treatment of diseases.</div></div><div><h3>Statement of significance</h3><div>Micro/nanomotors are the highly promising nanotherapeutic systems due to their self-propelled motion capability. Janus micro/nanomotors possess an asymmetric structure with different physical or chemical properties on both sides. The flexibility of this bifunctional surface allows them to hold promise for improving the penetration of nanotherapeutic systems and enhancing therapeutic efficacy for complex diseases. This review focuses on the latest advancements in Janus micro/nanomotors for enhanced disease treatment, including the structural types and driving mechanisms, the enhancement effect to cope with different disease treatments, the biocompatibility and safety, the current challenges and possible solutions. These insights inform the design of deep-penetrating nanotherapeutic systems and the strategies of enhanced disease treatment.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 50-77"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation-modulating elastic decellularized extracellular matrix scaffold promotes meniscus regeneration","authors":"Yangfan Ding ,&nbsp;Moran Huang ,&nbsp;Pengfei Cai ,&nbsp;Xiao Yu ,&nbsp;Jie Cui ,&nbsp;Binbin Sun ,&nbsp;Xiumei Mo ,&nbsp;Changrui Lu ,&nbsp;Jiwu Chen ,&nbsp;Jinglei Wu","doi":"10.1016/j.actbio.2025.02.043","DOIUrl":"10.1016/j.actbio.2025.02.043","url":null,"abstract":"<div><div>Scaffold-guided meniscus repair and regeneration show promise for meniscus injuries. Desirable scaffold properties are key to promoting proper tissue remodeling and effective regeneration. Herein, we report an inflammation-modulating elastic decellularized extracellular matrix (ECM) scaffold and evaluate its biological performance on meniscus repair in a rabbit model. An elastic scaffold of decellularized meniscus ECM (dmECM) was first prepared and functionalized with chitosan (CS) and ibuprofen (IBU) to obtain dmECM/CS-IBU scaffold. Our results show that CS and IBU grafting did not affect the overall properties of the dmECM/CS-IBU scaffold, including porous structure, good mechanical strength and elasticity. It promoted chondrocyte proliferation and preserved chondrogenic properties. In addition, both <em>in vitro</em> and <em>in vivo</em> assessments indicate that the dmECM/CS-IBU scaffold showed good anti-inflammatory properties and promoted pro-healing polarization of macrophages. In a partial rabbit meniscus defect model, the dmECM/CS-IBU scaffold showed promotive effects on <em>in situ</em> meniscus repair and preserved cartilage tissue. Therefore, our study provides a feasible strategy for fabricating scaffolds with tissue-specific bioactivity and inflammation-modulating abilities that synergistically promote meniscus repair and regeneration.</div></div><div><h3>Statement of significance</h3><div>Desirable scaffold properties are key to promoting proper tissue remodeling and effective regeneration of meniscus injuries. Herein, elastic decellularized scaffolds were prepared using natural meniscus and successfully grafted with chitosan and the anti-inflammatory drug ibuprofen (dmECM/CS-IBU). The dmECM/CS-IBU scaffold showed a pro-proliferative and phenotype- preserving effect on chondrocytes. In both <em>in vitro</em> and <em>in vivo</em> models, dmECM/CS-IBU scaffolds exhibited wonderful anti-inflammatory activity. In a meniscus white zone defect model, the dmECM/CS-IBU scaffold demonstrated <em>in situ</em> repair of tissue and protection of cartilage tissue. Therefore, we provides a feasible strategy for fabricating scaffolds with tissue-specific bioactivity and inflammation-modulating abilities that synergistically promote meniscus repair and regeneration.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 93-108"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymer-based nanocarriers to transport therapeutic biomacromolecules across the blood-brain barrier","authors":"Elena Romero-Ben ,&nbsp;Upashi Goswami ,&nbsp;Jackeline Soto-Cruz ,&nbsp;Amirreza Mansoori-Kermani ,&nbsp;Dhiraj Mishra ,&nbsp;Sergio Martin-Saldaña ,&nbsp;Jone Muñoz-Ugartemendia ,&nbsp;Alejandro Sosnik ,&nbsp;Marcelo Calderón ,&nbsp;Ana Beloqui ,&nbsp;Aitor Larrañaga","doi":"10.1016/j.actbio.2025.02.065","DOIUrl":"10.1016/j.actbio.2025.02.065","url":null,"abstract":"<div><div>Therapeutic biomacromolecules such as genetic material, antibodies, growth factors and enzymes represent a novel therapeutic alternative for neurological diseases and disorders. In comparison to traditional therapeutics, which are mainly based on small molecular weight drugs that address the symptoms of these disorders, therapeutic biomacromolecules can reduce undesired side effects and target specific pathological pathways, thus paving the way towards personalized medicine. However, these biomacromolecules undergo degradation/denaturation processes in the physiological environment and show poor capacity to cross the blood-brain barrier (BBB). Consequently, they rarely reach the central nervous system (CNS) in their active form. Herein, we critically overview several polymeric nanocarriers that can protect and deliver therapeutic biomacromolecules across the BBB. Polymeric nanocarriers are first categorized based on their architecture (biodegradable solid nanoparticles, nanogels, dendrimers, self-assembled nanoparticles) that ultimately determines their physico-chemical properties and function. The available polymeric formulations are then thoroughly analyzed, placing particular attention on those strategies that ensure the stability of the biomacromolecules during their encapsulation process and promote their passage across the BBB by controlling their physical (e.g., mechanical properties, size, surface charge) and chemical (e.g., surface functional groups, targeting motifs) properties. Accordingly, this review gives a unique perspective on polymeric nanocarriers for the delivery of therapeutic biomacromolecules across the BBB, representing a concise, complete and easy-to-follow guide, which will be of high interest for chemists, material scientists, pharmacologists, and biologists. Besides, it also provides a critical perspective about the limited clinical translation of these systems.</div></div><div><h3>Statement of significance</h3><div>The increasing incidence of central nervous system disorders is a major health concern. The use of therapeutic biomacromolecules has been placed in the spotlight of many investigations. However, reaching therapeutic concentration levels of biomacromolecules in the central nervous system is restricted by the blood-brain barrier and, thus, this represents the main clinical challenge when developing efficient therapies. Herein, we provide a critical discussion about the use of polymeric nanocarriers to deliver therapeutic biomacromolecules into the central nervous system, highlighting potential future directions to overcome the current challenges.</div></div>","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 17-49"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Polydopamine-based nanoplatform for photothermal ablation with long-term immune activation against melanoma and its recurrence” [Acta Biomaterialia, 136, 2021, 546-557]","authors":"Mengmeng Li,&nbsp;Rong Guo,&nbsp;Jiaojie Wei,&nbsp;Miao Deng,&nbsp;Jiaxin Li,&nbsp;Yuan Tao,&nbsp;Man Li,&nbsp;Qin He","doi":"10.1016/j.actbio.2025.01.054","DOIUrl":"10.1016/j.actbio.2025.01.054","url":null,"abstract":"","PeriodicalId":237,"journal":{"name":"Acta Biomaterialia","volume":"196 ","pages":"Pages 530-531"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}