Michael Berk, Ole Köhler-Forsberg, Megan Turner, Brenda W J H Penninx, Anna Wrobel, Joseph Firth, Amy Loughman, Nicola J Reavley, John J McGrath, Natalie C Momen, Oleguer Plana-Ripoll, Adrienne O'Neil, Dan Siskind, Lana J Williams, Andre F Carvalho, Lianne Schmaal, Adam J Walker, Olivia Dean, Ken Walder, Lesley Berk, Seetal Dodd, Alison R Yung, Wolfgang Marx
Populations with common physical diseases - such as cardiovascular diseases, cancer and neurodegenerative disorders - experience substantially higher rates of major depressive disorder (MDD) than the general population. On the other hand, people living with MDD have a greater risk for many physical diseases. This high level of comorbidity is associated with worse outcomes, reduced adherence to treatment, increased mortality, and greater health care utilization and costs. Comorbidity can also result in a range of clinical challenges, such as a more complicated therapeutic alliance, issues pertaining to adaptive health behaviors, drug-drug interactions and adverse events induced by medications used for physical and mental disorders. Potential explanations for the high prevalence of the above comorbidity involve shared genetic and biological pathways. These latter include inflammation, the gut microbiome, mitochondrial function and energy metabolism, hypothalamic-pituitary-adrenal axis dysregulation, and brain structure and function. Furthermore, MDD and physical diseases have in common several antecedents related to social factors (e.g., socioeconomic status), lifestyle variables (e.g., physical activity, diet, sleep), and stressful live events (e.g., childhood trauma). Pharmacotherapies and psychotherapies are effective treatments for comorbid MDD, and the introduction of lifestyle interventions as well as collaborative care models and digital technologies provide promising strategies for improving management. This paper aims to provide a detailed overview of the epidemiology of the comorbidity of MDD and specific physical diseases, including prevalence and bidirectional risk; of shared biological pathways potentially implicated in the pathogenesis of MDD and common physical diseases; of socio-environmental factors that serve as both shared risk and protective factors; and of management of MDD and physical diseases, including prevention and treatment. We conclude with future directions and emerging research related to optimal care of people with comorbid MDD and physical diseases.
{"title":"Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management.","authors":"Michael Berk, Ole Köhler-Forsberg, Megan Turner, Brenda W J H Penninx, Anna Wrobel, Joseph Firth, Amy Loughman, Nicola J Reavley, John J McGrath, Natalie C Momen, Oleguer Plana-Ripoll, Adrienne O'Neil, Dan Siskind, Lana J Williams, Andre F Carvalho, Lianne Schmaal, Adam J Walker, Olivia Dean, Ken Walder, Lesley Berk, Seetal Dodd, Alison R Yung, Wolfgang Marx","doi":"10.1002/wps.21110","DOIUrl":"10.1002/wps.21110","url":null,"abstract":"<p><p>Populations with common physical diseases - such as cardiovascular diseases, cancer and neurodegenerative disorders - experience substantially higher rates of major depressive disorder (MDD) than the general population. On the other hand, people living with MDD have a greater risk for many physical diseases. This high level of comorbidity is associated with worse outcomes, reduced adherence to treatment, increased mortality, and greater health care utilization and costs. Comorbidity can also result in a range of clinical challenges, such as a more complicated therapeutic alliance, issues pertaining to adaptive health behaviors, drug-drug interactions and adverse events induced by medications used for physical and mental disorders. Potential explanations for the high prevalence of the above comorbidity involve shared genetic and biological pathways. These latter include inflammation, the gut microbiome, mitochondrial function and energy metabolism, hypothalamic-pituitary-adrenal axis dysregulation, and brain structure and function. Furthermore, MDD and physical diseases have in common several antecedents related to social factors (e.g., socioeconomic status), lifestyle variables (e.g., physical activity, diet, sleep), and stressful live events (e.g., childhood trauma). Pharmacotherapies and psychotherapies are effective treatments for comorbid MDD, and the introduction of lifestyle interventions as well as collaborative care models and digital technologies provide promising strategies for improving management. This paper aims to provide a detailed overview of the epidemiology of the comorbidity of MDD and specific physical diseases, including prevalence and bidirectional risk; of shared biological pathways potentially implicated in the pathogenesis of MDD and common physical diseases; of socio-environmental factors that serve as both shared risk and protective factors; and of management of MDD and physical diseases, including prevention and treatment. We conclude with future directions and emerging research related to optimal care of people with comorbid MDD and physical diseases.</p>","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":null,"pages":null},"PeriodicalIF":73.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503929/pdf/WPS-22-366.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10305833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The WPA Expert International Advisory Panel for Early Intervention in Psychosis in Low- and Middle-Income Countries: an update on recent relevant activities.","authors":"Swaran P Singh, Afzal Javed, Rangaswamy Thara, Rakesh Chadda, Srividya Iyer, Nikos Stefanis","doi":"10.1002/wps.21130","DOIUrl":"10.1002/wps.21130","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":null,"pages":null},"PeriodicalIF":73.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503914/pdf/WPS-22-489.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10309573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danuta Wasserman, Celso Arango, Andrea Fiorillo, Saul Levin, Andrew Peters, Prasad Rao, Thelma Sanchez-Villanueva, Aida Sylla
{"title":"Improving mental health through fostering healthy lifestyles in young people: one of the targets in the WPA Action Plan 2023-2026.","authors":"Danuta Wasserman, Celso Arango, Andrea Fiorillo, Saul Levin, Andrew Peters, Prasad Rao, Thelma Sanchez-Villanueva, Aida Sylla","doi":"10.1002/wps.21146","DOIUrl":"10.1002/wps.21146","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":null,"pages":null},"PeriodicalIF":73.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503912/pdf/WPS-22-488.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10309578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Umberto Volpe, Rodrigo Ramalho, Laura Orsolini, Ramdas Ransing, Renato de Filippis, Ahmet Gürcan, Shreyasta Samal, Wolfgang Gaebel
{"title":"An update from the WPA Working Group on Digitalization in Mental Health and Care.","authors":"Umberto Volpe, Rodrigo Ramalho, Laura Orsolini, Ramdas Ransing, Renato de Filippis, Ahmet Gürcan, Shreyasta Samal, Wolfgang Gaebel","doi":"10.1002/wps.21143","DOIUrl":"10.1002/wps.21143","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":null,"pages":null},"PeriodicalIF":73.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503917/pdf/WPS-22-494.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10358837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashley E Nordsletten, Kayoko Isomura, James J Crowley, Matti Cervin, Henrik Larsson, Paul Lichtenstein, David Mataix-Cols, Anna Sidorchuk
{"title":"Labour market marginalization in children of persons with major psychiatric disorders: a Swedish national cohort study.","authors":"Ashley E Nordsletten, Kayoko Isomura, James J Crowley, Matti Cervin, Henrik Larsson, Paul Lichtenstein, David Mataix-Cols, Anna Sidorchuk","doi":"10.1002/wps.21127","DOIUrl":"10.1002/wps.21127","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":null,"pages":null},"PeriodicalIF":73.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503925/pdf/WPS-22-483.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10309571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jurjen J Luykx, Frank Gerritse, Philippe C Habets, Christiaan H Vinkers
{"title":"The performance of ChatGPT in generating answers to clinical questions in psychiatry: a two-layer assessment.","authors":"Jurjen J Luykx, Frank Gerritse, Philippe C Habets, Christiaan H Vinkers","doi":"10.1002/wps.21145","DOIUrl":"10.1002/wps.21145","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":null,"pages":null},"PeriodicalIF":73.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503909/pdf/WPS-22-479.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10308187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Catatonia and its varieties: an update.","authors":"Andrew Francis, Charles Mormando","doi":"10.1002/wps.21119","DOIUrl":"10.1002/wps.21119","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":null,"pages":null},"PeriodicalIF":73.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503915/pdf/WPS-22-476.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10308179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mark van Ommeren, Sian Lewis, Edith Van't Hof, Kenneth Carswell
{"title":"Putting psychological interventions first in primary health care.","authors":"Mark van Ommeren, Sian Lewis, Edith Van't Hof, Kenneth Carswell","doi":"10.1002/wps.21114","DOIUrl":"10.1002/wps.21114","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":null,"pages":null},"PeriodicalIF":73.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10337472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Progress in understanding functional somatic symptoms and syndromes in light of the ICD-11 and DSM-5.","authors":"Francis Creed","doi":"10.1002/wps.21118","DOIUrl":"10.1002/wps.21118","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":null,"pages":null},"PeriodicalIF":73.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503926/pdf/WPS-22-474.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10308180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent developments pertaining to treatment-resistant depression: a 40-year perspective.","authors":"Michael E Thase","doi":"10.1002/wps.21134","DOIUrl":"10.1002/wps.21134","url":null,"abstract":"","PeriodicalId":23858,"journal":{"name":"World Psychiatry","volume":null,"pages":null},"PeriodicalIF":73.3,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10503918/pdf/WPS-22-413.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10308177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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