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Avicenna's views on pest control and medicinal plants he prescribed as natural pesticides. 阿维森纳对害虫防治的看法,以及他作为天然杀虫剂开出的药用植物处方。
IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-01 Epub Date: 2024-02-22 DOI: 10.1007/s10354-024-01034-y
Mohammad Amrollahi-Sharifabadi, Jamal Rezaei Orimi, Zahra Adabinia, Tahereh Shakeri, Zahra Aghabeiglooei, Mohammad Hashemimehr, Maedeh Rezghi

The present study aimed to introduce Avicenna's views on pest control and the medicinal plants he proposed as natural pesticides. Also, we addressed the strategies that he leveraged to formulate and prescribe them, and, finally, we put his views into perspective with modern science. The data were collected using Al-Qanun Fi Al-Tibb (The Canon of Medicine) as well as scientific databases. According to Al-Qanun Fi Al-Tibb, 42 medicinal plants are described as natural pest control agents. After introducing the pest control properties of each plant, Avicenna explained the appropriate strategies for use of these plants. These strategies or formulations included incensing, spraying, spreading, rubbing, smudging, and scent-dispersing, which are equivalent to the modern pesticide formulations of fumigants, aerosols, pastes and poisoned baits, lotions, creams, and slow-release formulations, respectively. This study revealed that Avicenna introduced the pest control approach with natural plants in his book Al-Qanun Fi Al-Tibb and, thus, harnessed the power of nature to control nature. Future research is recommended to find the pest control merits of the presented medicinal plants, in order to incorporate them into pest control programs and reduce environmental pollution resulting from the complications of current synthetic pesticides.

本研究旨在介绍阿维森纳关于虫害防治的观点以及他提出的可作为天然杀虫剂的药用植物。此外,我们还探讨了他制定和处方这些药用植物的策略,最后,我们将他的观点与现代科学相结合。我们利用《药典》(Al-Qanun Fi Al-Tibb)和科学数据库收集数据。根据 Al-Qanun Fi Al-Tibb,42 种药用植物被描述为天然害虫控制剂。在介绍了每种植物的害虫控制特性后,阿维森纳解释了使用这些植物的适当策略。这些策略或配方包括熏、喷、撒、擦、熏和散香,分别相当于现代杀虫剂的熏蒸剂、气雾剂、糊剂和毒饵、洗剂、霜剂和缓释制剂。这项研究表明,阿维森纳在其《Al-Qanun Fi Al-Tibb》一书中提出了用天然植物控制害虫的方法,从而利用自然的力量来控制自然。建议今后开展研究,找出所介绍的药用植物在害虫控制方面的优点,以便将其纳入害虫控制计划,减少目前合成杀虫剂的复杂性所造成的环境污染。
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引用次数: 0
The death of the Empress Elisabeth of Austria and Queen of Hungary-retold and reassessed with reconstruction of her autopsy. 奥地利伊丽莎白皇后和匈牙利王后之死--通过对其尸体解剖的重建重述和重新评估。
IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-01 Epub Date: 2024-05-17 DOI: 10.1007/s10354-024-01042-y
Roland Sedivy

In this publication 125 years after the violent death of the famous Empress Elisabeth (1837-1898) of Austria, known as Sisi, a modern evaluation as well as valuation will be presented. The day after her assassination by the young anarchist Luigi Lucheni using a file, a partial autopsy was performed to find out the exact cause of death-a pericardial tamponade. The complete translation of the autopsy report is part of this article, the intention being to avoid unclear wording and translation errors, which have often caused some confusion in the past. A pictorial illustration of the puncture canal will provide clarity through medical facts as to how Empress Elisabeth's death came about by correct pathological and anatomical description and, thus, counteract former interpretations.

在著名的奥地利伊丽莎白皇后(1837-1898 年)(人称西西)暴死 125 年后,本出版物将对她进行现代评估和评价。在她被年轻的无政府主义者路易吉-卢切尼(Luigi Lucheni)用锉刀刺杀的第二天,进行了部分尸检,以查明确切的死因--心包填塞。验尸报告的完整译文是本文的一部分,目的是避免过去经常引起混淆的措辞不清和翻译错误。穿刺管的图解将通过正确的病理学和解剖学描述,以医学事实澄清伊丽莎白皇后的死因,从而反驳以前的解释。
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引用次数: 0
Pattern of bioterrorism in ancient times: lessons to be learned from the microbial and toxicological aspects. 古代生物恐怖主义的模式:从微生物和毒理学方面吸取的教训。
IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-01 Epub Date: 2024-01-09 DOI: 10.1007/s10354-023-01029-1
Elaheh Eslami, Hasan Siamian, Jamal Rezaei Orimi, Zahra Aghabeiglooei, Ebrahim Salimi-Sabour, Mohammad Amrollahi-Sharifabadi

The current research aimed to analyze the history of bioterrorism in antiquity and to adapt the data to modern medical knowledge. To this end, a thorough evaluation of the literature related to the ancient history of bioterrorism and modern data was done using the Web of Sciences, Science Direct, Scopus, PubMed, and Google Scholar. Results showed that knowledge of bioterrorism has existed since antiquity in different civilizations. Biological and toxicological agents were used as an instrument of legal execution, as a warfare tool in battles, or to eliminate political rivals across nations. Ancient people researched bioterrorism to apply it against enemies and at the same time provide countermeasures in favor of themselves and allies. Despite the existence of the principles of bioterrorism since ancient times, adaptation of the data to modern research can assist in planning countermeasure efforts, preventive actions, and treatments in the framework of modern counterterrorism medicine.

目前的研究旨在分析古代生物恐怖主义的历史,并将这些数据与现代医学知识相适应。为此,我们利用 Web of Sciences、Science Direct、Scopus、PubMed 和 Google Scholar 对与古代生物恐怖主义历史相关的文献和现代数据进行了全面评估。结果表明,生物恐怖主义的知识自古以来就存在于不同的文明中。生物制剂和毒理制剂曾被用作合法处决的工具、战争中的作战工具或消灭国家间的政治对手。古人研究生物恐怖主义的目的是将其用于对付敌人,同时为自己和盟友提供反制措施。尽管生物恐怖主义的原理自古就有,但将这些数据与现代研究相结合,有助于在现代反恐医学的框架内规划应对措施、预防行动和治疗方法。
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引用次数: 0
The pathological anatomical collection of the Natural History Museum Vienna. 维也纳自然历史博物馆的病理解剖藏品。
IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-01 Epub Date: 2023-02-02 DOI: 10.1007/s10354-022-01001-5
Eduard Winter, Maria Teschler-Nicola, Karin Macfelda, Katrin Vohland

The pathological anatomical collection Vienna (Pathologisch-Anatomische Sammlung Wien; PASW) is a living and still growing research collection. It was established as early as 1796 as part of the Medical University of Vienna, acquired the status of an independent federal museum in 1971, and was assigned to the Natural History Museum Vienna in 2012. It houses a wide range of human wet and dry specimens and further objects, such as moulages, medical devices, microbiological and histological specimens, and a photo archive (approximately 50,000 objects), which, as a meaningful source, may contribute to disclosing not only aspects of the medical history and the development of corresponding museums in Vienna, but is also considered a collection of cultural and current scientific relevance, quite comparable to today's biobanks. Most of the tissue amassment represents wet organic specimens and human skeletons or skeletal elements representing, e.g., congenital and metabolic disorders, infectious diseases, injuries, neoplasms, or musculoskeletal diseases, basically collected as descriptive anatomical teaching aids. This article reviews the current medical issues on which research has been and is being conducted by including PASW specimens (hereby using the ICD-10 code), and the extent to and ethical conditions under which this important heritage could be used as a reference collection for clinical and bioanthropological (paleopathological and palaeoepidemiological) studies; finally, this article reflects on the value and future research prospects, taking into account different positions and the ongoing discussions in pathological anatomical human tissue collections.

维也纳病理解剖收藏馆(Pathologisch-Anatomische Sammlung Wien; PASW)是一个有生命力且仍在不断发展的研究收藏馆。早在 1796 年,它就作为维也纳医科大学的一部分建立起来,1971 年获得独立联邦博物馆的地位,2012 年划归维也纳自然历史博物馆。馆内收藏了大量人体干湿标本和其他物品,如模型、医疗器械、微生物和组织学标本,以及照片档案(约 50,000 件物品),作为有意义的资料来源,不仅有助于揭示维也纳医学史和相应博物馆发展的方方面面,还被视为具有文化和当前科学意义的藏品,可与当今的生物库相媲美。馆藏的大部分组织都是湿的有机标本和人体骨骼或骨骼元素,如先天性和代谢性疾病、传染病、外伤、肿瘤或肌肉骨骼疾病,基本上都是作为描述性解剖学教具收集的。这篇文章回顾了目前已经和正在进行的通过纳入 PASW 标本(此处使用 ICD-10 编码)进行研究的医学问题,以及在何种程度和伦理条件下可以将这一重要遗产用作临床和生物人类学(古病理学和古流行病学)研究的参考藏品;最后,考虑到病理解剖人体组织藏品的不同立场和正在进行的讨论,这篇文章对其价值和未来研究前景进行了反思。
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引用次数: 0
[The trembling heart of the monarch-Insights into the heart condition of Emperor Maximilian II]. [君主颤抖的心洞察皇帝马克西米利安二世的心脏状况]。
IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-10-01 Epub Date: 2023-10-06 DOI: 10.1007/s10354-023-01022-8
Tobias Heusinger, Michael Stolberg

It has long been known in historical research that the Habsburg Emperor Maximilian II (1527-1576) suffered from heart complaints throughout his life. Numerous biographers mention this fact. His medical history and even the results of the autopsy of his body have been handed down; however, it has not been sufficiently investigated how Maximilian's physicians explained his heart condition, often referred to as "tremor cordis", and what causes and triggers they held responsible for this complaint in general and in the specific case of their famous patient. This article addresses these questions, primarily on the basis of a detailed consultation by the imperial personal physician Andrea Gallo, dating from 1555. Gallo's consilium, which has been ignored by scholares so far, first summarizes the state of knowledge on heart tremors at that time. It then turns to Maximilian's case and provides revealing insights into his mental state.

历史研究早就知道,哈布斯堡皇帝马克西米利安二世(1527-1576)一生都患有心脏病。许多传记作家都提到了这一事实。他的病史,甚至尸体解剖的结果都已流传下来;然而,尚未充分调查Maximilian的医生如何解释他的心脏病,通常被称为“心脏震颤”,以及他们认为是什么原因和诱因导致了这一投诉,以及他们著名患者的具体情况。本文主要基于1555年帝国私人医生安德里亚·加洛的详细咨询,解决了这些问题。迄今为止一直被学者忽视的加洛共识,首先总结了当时对心脏震颤的认识状态。然后,它转向马克西米利安的案件,并提供了对他的精神状态的启示。
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引用次数: 0
Diagnostic difficulties in pediatric annular dermatoses. 儿科环状皮肤病的诊断难题。
IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-01 Epub Date: 2023-08-11 DOI: 10.1007/s10354-023-01019-3
Doris Weiss, Philipp Weber, Amélie Hampel, Julia Tittes, Wolfgang Weninger, Tamar Kinaciyan

The polymorphic presentation of annular dermatoses in the pediatric population renders them a diagnostic challenge to the clinician. They include various distinct disease entities that can be vaguely categorized according to the age of onset. Herein, we report on a young girl with clinical characteristics of Wells' syndrome, while histological findings favored the diagnosis of annular erythema of infancy (AEI). Although morphological and histological similarities do exist, AEI and eosinophilic annular erythema (EAE) of childhood are considered as distinct entities in the literature. Wells' syndrome (WS) is an eosinophilic dermatosis and histologically characterized by eosinophilic dermal infiltration with the hallmark feature of "flame figures." Based on this case, we discuss and review the differential diagnoses of annular dermatoses in children.

环状皮肤病在儿童群体中的多形性表现给临床医生的诊断带来了挑战。它们包括各种不同的疾病实体,可根据发病年龄进行模糊分类。在本文中,我们报告了一名具有威尔斯综合征临床特征的小女孩,而组织学结果则倾向于婴儿环形红斑(AEI)的诊断。虽然在形态学和组织学上确实存在相似之处,但文献中将 AEI 和嗜酸性粒细胞环状红斑(EAE)视为不同的实体。威尔斯综合征(WS)是一种嗜酸性粒细胞皮肤病,组织学特征为嗜酸性粒细胞真皮浸润,其标志性特征为 "火焰图"。根据该病例,我们讨论并回顾了儿童环状皮肤病的鉴别诊断。
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引用次数: 0
Diaper dermatitis-a narrative review of clinical presentation, subtypes, and treatment. 尿布皮炎——临床表现、亚型和治疗的叙述性综述。
IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-01 Epub Date: 2023-10-20 DOI: 10.1007/s10354-023-01024-6
Anca Chiriac, Uwe Wollina

Diaper dermatitis (DD) is an umbrella term with different clinical presentations, pathophysiology, treatments, and outcomes. The major subtypes include irritant contact dermatitis and candida-associated DD. In case of atypical presentation or unresponsiveness to treatment, other differential diagnoses should be considered. Although DD can occur at any age, it peaks in newborns and infants < 2 years of age. We will focus on this age group in our narrative review.

尿布皮炎(DD)是一个总括性术语,具有不同的临床表现、病理生理学、治疗和结果。主要亚型包括刺激性接触性皮炎和念珠菌相关DD。如果出现非典型症状或对治疗无反应,应考虑其他鉴别诊断。尽管DD可以发生在任何年龄,但它在新生儿和婴儿中达到峰值
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引用次数: 0
Study draft: "UVC-You Will See" study: longer vs. shorter umbilical venous catheter (UVC) dwell time (6-10 vs. 1-5 days) in very premature infants with birth weight < 1250 g and/or gestational age < 30 weeks. 研究草案:"UVC-You Will See "研究:在出生体重小于 1250 克和/或胎龄小于 30 周的极早产儿中,延长脐静脉导管(UVC)停留时间(6-10 天对 1-5 天)与缩短脐静脉导管停留时间(6-10 天对 1-5 天)的对比。
IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-01 Epub Date: 2024-06-13 DOI: 10.1007/s10354-024-01047-7
Sascha Meyer, Steffi Hess, Martin Poryo, Cihan Papan, Arne Simon, Silvia Welcker, Anne Ehrlich, Christian Ruckes

Background: Umbilical venous catheters (UVCs) are often used in preterm infants. Their use is associated with complications (infections, clot formation, organ injury). Very preterm infants with acquired bloodstream infection are at a higher risk for death and important morbidities (e.g., adverse neurodevelopmental outcomes). It is standard clinical practice to remove UVCs in the first days of life. Replacement of intravenous access is often performed using percutaneously inserted central catheters (PICCs). It is unclear whether serial central line use affects the rates of catheter-related complications.

Methods: A multicenter randomized controlled trial (random group assignment) was performed in 562 very premature (gestational age < 30 weeks) and/or very low birth weight infants (< 1250 g) requiring an UVC for administration of parenteral nutrition and/or drugs. Group allocation was random.

Hypothesis: A UVC dwell time of 6-10 days (281 infants) is not associated with an increased rate of central venous catheter (UVC, PICC)-related complications compared to 1-5 days (281 infants), and a longer UVC dwell time will significantly reduce the number of painful, invasive procedures associated with the need for vascular access as well as radiation exposure, use of antibiotics, and medical costs.

Primary outcome parameter: The number of catheter-related bloodstream infections and/or catheter-related thromboses and/or catheter-associated organ injuries related to the use of UVC/PICC was the primary outcome.

Conclusion: Extending the UVC dwell time may significantly reduce the number of painful invasive procedures, with the potential to positively impact not only long-term pain perception but also important social competencies (attention, learning, and behavior). Thus, the "UVC-You Will See" study has the potential to substantially change current neonatal intensive care practice.

背景:脐静脉导管(UVC)常用于早产儿。其使用与并发症(感染、血栓形成、器官损伤)有关。患有后天性血流感染的极早产儿死亡和出现重要疾病(如不良的神经发育结果)的风险较高。标准的临床实践是在婴儿出生后的最初几天拔除 UVC。更换静脉通路通常使用经皮插入中心导管(PICC)。目前还不清楚连续使用中心静脉导管是否会影响导管相关并发症的发生率:多中心随机对照试验(随机分组)在 562 名早产儿(胎龄假设:与 1-5 天(281 名婴儿)相比,6-10 天(281 名婴儿)的紫外线停留时间与中心静脉导管(UVC、PICC)相关并发症发生率的增加无关,更长的紫外线停留时间将显著减少与血管通路需求相关的痛苦、侵入性操作的次数,以及辐射暴露、抗生素的使用和医疗成本:导管相关血流感染和/或导管相关血栓形成和/或与使用紫外线/PICC 相关的导管相关器官损伤的数量是主要结果:延长紫外线停留时间可显著减少痛苦的侵入性操作次数,不仅有可能对长期痛觉产生积极影响,还可能对重要的社会能力(注意力、学习和行为)产生积极影响。因此,"紫外线-你会看到 "研究有可能极大地改变当前的新生儿重症监护实践。
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引用次数: 0
Insights into coeliac disease diagnosis: a 2021-2023 overview of diagnostic approach and delays in children in Slovenia. 对腹腔疾病诊断的见解:2021-2023 年斯洛文尼亚儿童诊断方法和延误概述。
IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-01 Epub Date: 2024-06-05 DOI: 10.1007/s10354-024-01045-9
Petra Rižnik, Tina Kamhi Trop, Martina Klemenak, Tomaž Krenčnik, Tanja Milanič-Koron, Eva Miler Mojškerc, Tatjana Pavlin, Tina Požek Šavs, Janez Zupančič, Jernej Dolinšek

Introduction: Over the past decade, the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) proposed the option of diagnosing coeliac disease (CD) in children without duodenal biopsy. The aim of our study was to assess the diagnostic approach in newly diagnosed children with CD in Slovenia.

Methods: In this prospective study, Slovenian paediatric gastroenterologists were invited to provide medical records of children under 19 years diagnosed with CD from March 2021 to October 2023. The analysis focused on tissue transglutaminase antibody (TGA) levels at diagnosis, diagnostic approach, adherence to ESPGHAN CD guidelines and diagnostic delays.

Results: Data from 160 newly diagnosed CD patients (61.9% female; median age 8 years; 16.9% asymptomatic) were available for the analysis. No-biopsy approach was used in 65% (N = 104) of children and the majority (N = 101) fulfilled all the criteria for the no-biopsy approach. Of 56 children diagnosed using duodenal biopsy, a further 10 (17.8%) would have also been eligible for the no-biopsy approach based on the very high levels of TGA. Median diagnostic delay from first symptoms to confirmation of diagnosis was 6 months (min 0 months, max 87 months). Use of the no-biopsy approach has risen significantly since 2016 (37.8% vs. 65.0%; p = 0.001) and diagnostic delays have shortened (6 vs. 7 months; p < 0.05).

Conclusion: This prospective study highlights the frequent use of a no-biopsy approach for diagnosing CD in children in Slovenia, showing large adherence to ESPGHAN guidelines. Also, diagnostic delays have shortened over recent years, likely due to various awareness-raising projects on CD conducted during this period.

简介:在过去的十年中,欧洲儿科胃肠病学、肝脏病学和营养学会(ESPGHAN)提出了无需十二指肠活检即可诊断儿童腹腔疾病(CD)的方案。我们的研究旨在评估斯洛文尼亚新诊断出的 CD 儿童的诊断方法:在这项前瞻性研究中,斯洛文尼亚儿科胃肠病专家受邀提供 2021 年 3 月至 2023 年 10 月期间诊断为 CD 的 19 岁以下儿童的医疗记录。分析的重点是诊断时的组织转谷氨酰胺酶抗体(TGA)水平、诊断方法、ESPGHAN CD指南的遵守情况以及诊断延误:160名新确诊的CD患者(61.9%为女性;中位年龄为8岁;16.9%无症状)的数据可供分析。65%的患儿(104例)采用了无活检方法,大多数患儿(101例)符合无活检方法的所有标准。在通过十二指肠活检确诊的 56 名患儿中,另有 10 名患儿(17.8%)因 TGA 水平非常高而符合免活检方法的条件。从首次出现症状到确诊的中位诊断延迟时间为 6 个月(最短 0 个月,最长 87 个月)。自 2016 年以来,无活检方法的使用率显著上升(37.8% 对 65.0%;P = 0.001),诊断延迟也有所缩短(6 个月对 7 个月;P 结论:这项前瞻性研究突出表明,斯洛文尼亚在诊断儿童 CD 时经常使用无活检方法,这表明该方法在很大程度上遵守了 ESPGHAN 指南。此外,近年来诊断延误的时间也有所缩短,这很可能是由于在此期间开展了各种提高对 CD 认识的项目。
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引用次数: 0
Something is up in the air: pneumothorax and pneumopericardium in a 29-week preterm infant. 空气中弥漫着某种东西:一名29周早产婴儿的肺气肿和心包积气。
IF 1.1 Q2 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-01 Epub Date: 2023-09-26 DOI: 10.1007/s10354-023-01021-9
Sascha Meyer, Sarah Ruffing, Martina Geipel, Martin Poryo, Alexander Larsen, Sogand Nemat

This report highlights the early and unusual detection of a pneumopericardium by echocardiography prior to potential development of cardiocirculatory compromise. It is important to consider pneumopericardium into the differential diagnosis when difficulties arise in the visualization of the heart by conventional echocardiography. Pneumopericardium is associated with a high mortality rate and may be effectively treated by immediate insertion of a pericardial catheter.

本报告强调了在潜在的心循环损害发生之前,超声心动图对心包积气的早期和异常检测。当常规超声心动图显示心脏出现困难时,在鉴别诊断中考虑心包积气是很重要的。心包积液死亡率高,可通过立即插入心包导管进行有效治疗。
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引用次数: 0
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Wiener medizinische Wochenschrift
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