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Risk Factors Associated with Bisphosphonates Related Osteonecrosis of the Jaw: A National Insurance Senior Cohort Database Study 与双膦酸盐相关的颌骨骨坏死相关的危险因素:一项国家保险老年人队列数据库研究
Pub Date : 2022-08-30 DOI: 10.17480/psk.2022.66.4.210
Jun Hyeob Kim, Tae Hyeok Kim, K. Lee
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe side effect of bisphosphonate, which is usually prescribed as a treatment for diseases such as multiple myeloma, bone metastases, osteoporosis, and Paget disease. To investigate the risk factors of BRONJ, we conducted a nested case-control study using the Korean National Insurance Health Service-senior cohort. Patients newly diagnosed with BRONJ were selected as the case group, while the control group included patients who were never diagnosed with BRONJ. A risk-set sampling method was used to select the control group using age, sex, the date of the first prescription of bisphosphonate, and follow-up duration. Of the 22,236 subjects, 4,455 were included in the case group. Arthrosis, rheumatoid arthritis, neuropathies, myocardial infarction, renal disease, cancer, liver disease, and tooth extraction were associated with a higher incidence of BRONJ than subjects without such conditions (aOR, 95% CI: 1.58 [1.47-1.71], 1.46 [1.30-1.63], 1.31 [1.20-1.42], 1.23 [1.01-1.49], 1.36 [1.10-1.68], 1.27 [1.12-1.45], 1.63 [1.10-2.43], and 1.64 [1.53-1.76] respectively). In conclusion, of the factors examined, we confirmed that liver disease and tooth extraction were related to an increased risk of BRONJ.
双膦酸盐相关性颌骨骨坏死(BRONJ)是双膦酸盐的严重副作用,通常用于治疗多发性骨髓瘤、骨转移、骨质疏松症和佩吉特病等疾病。为了调查BRONJ的危险因素,我们使用韩国国民健康保险服务-老年人队列进行了一项巢式病例对照研究。新诊断为BRONJ的患者为病例组,对照组为未诊断为BRONJ的患者。采用风险集抽样方法,根据年龄、性别、双膦酸盐首次处方日期和随访时间选择对照组。在22236名受试者中,有4455人被纳入病例组。关节、类风湿关节炎、神经病变、心肌梗死、肾脏疾病、癌症、肝脏疾病和拔牙与BRONJ的发生率均高于无此类疾病的受试者(aOR, 95% CI分别为1.58[1.47-1.71]、1.46[1.30-1.63]、1.31[1.20-1.42]、1.23[1.01-1.49]、1.36[1.10-1.68]、1.27[1.12-1.45]、1.63[1.10-2.43]和1.64[1.53-1.76])。总之,在检查的因素中,我们证实肝脏疾病和拔牙与BRONJ风险增加有关。
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引用次数: 0
Current Status of Pharmacist-run Personal Broadcasting and Pharmacists’ Perceptions on Self-regulation by Korean Pharmaceutical Association 韩国药学会药师个人广播现状及药师自律意识
Pub Date : 2022-06-30 DOI: 10.17480/psk.2022.66.3.152
Kathryn Lim, Hyun Jin Kim, H. Park, Hyunjoo Sohn
With the rapid penetration of internet-based communication into all industries, YouTube®, a video-sharing platform, has come to be widely used in the healthcare field. This study aims to investigate the current status of pharmacist-run personal broadcast (PRPB) in Korea and explore the underlying perceptions held by pharmacists. YouTube searches made from May to June 2020 and June 2022 were analyzed, followed by a cross-sectional questionnaire survey during July 2020. A 13-item questionnaire was distributed via social media channels to recruit pharmacists using the convenience sampling method. Currently, there are a total of 91 PRPB channels on YouTube, most of which were started after 2019. Of the total 1267 contents, health functional foods (32.4%) and over the counter products (29.3%) had the highest proportions. Among the 218 respondents of the questionnaire survey, 49.1% were working in community pharmacies, and only 2.8% had PRPB experience. They showed higher positive response (42.2%) than negative (33.5%) for the public's exposure to PRPB, and 77.5% of the respondents perceived that social influence of PRPB will grow bigger. Their concerns about PRPB were mainly disclosure of biased information and possibility to lead to product purchase (75.2%) and spreading unverified information (70.2%). In addition, 70.6% of the respondents agreed with the necessity of self-regulation of PRPB by the Korean Pharmaceutical Association and chose the operation of a civil petition counter to report the transmission of false or incorrect information on YouTube (62.8%) and composition of deliberation committee and periodic monitoring (53.2%) as regulatory methods. Perceived necessity of self-regulation was significantly higher in the above-50s age group than in the under-40s group (p<0.05). Pharmacists interested in PRPB should deliver accurate information as drug information providers and abide by professional ethics and public responsibility.
随着互联网通信在各行各业的迅速渗透,YouTube®视频分享平台在医疗保健领域得到了广泛的应用。本研究旨在调查韩国药剂师经营个人广播(PRPB)的现状,并探讨药剂师持有的潜在观念。对2020年5月至6月和2022年6月的YouTube搜索进行了分析,随后在2020年7月进行了横断面问卷调查。采用方便抽样法,通过社交媒体渠道发放共13项问卷,招募药师。目前,YouTube上共有91个PRPB频道,其中大部分是在2019年之后启动的。其中,保健功能食品(32.4%)和非处方药(29.3%)所占比例最高。在218名问卷调查对象中,49.1%的人在社区药房工作,只有2.8%的人有PRPB经验。对公众接触“三保”的正面反应(42.2%)高于负面反应(33.5%),77.5%的受访者认为“三保”的社会影响会越来越大。他们对PRPB的担忧主要是披露有偏见的信息和导致购买产品的可能性(75.2%)和传播未经证实的信息(70.2%)。另外,70.6%的应答者认为药品协会有必要对药品监督委员会进行自我规制,并选择了举报在YouTube上传播虚假或不正确信息的民事请愿柜台(62.8%)和组成审议委员会及定期监督(53.2%)等规制方式。50岁以上年龄组的自我调节必要性感知显著高于40岁以下年龄组(p<0.05)。药师作为药品信息提供者,应当提供准确的信息,恪守职业道德和公共责任。
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引用次数: 0
Protective Effect of Angelica gigas Nakai Extract Against Blue Light-induced Cell Death on Human Retinal Pigmented Epithelium (ARPE-19) Cell Viability 当归提取物抗蓝光致细胞死亡对人视网膜色素上皮(ARPE-19)细胞活力的保护作用
Pub Date : 2022-06-30 DOI: 10.17480/psk.2022.66.3.146
Hyeon Woo Kim, Youn Je Lee, H. Kang, Hyeong-Hoi Kim, Il Dae Song, J. Kang
Light pollution such as blue light exposure can damage the visual photoreceptors and lead to cell death and degenerative retinal diseases. Despite the increasing number of patients suffering from retinal disease, the therapeutic agents are still insufficient. Angelica gigas Nakai extract (AGNEX) containing a high proportion of decursin derivatives has effectively protected cells under oxidative stress or high-level blue light. However, it remains unclear whether it protects retinal cells effectively. Here, we investigated the cytoprotective effect of AGNEX on retinal cells damaged using reactive oxygen species (ROS), which decreased the viability of retinal cells by causing oxidative stress. The cell viability with 600 μM hydrogen peroxide treatment was less than 70% of the normal control group. However, the group treated with 40 μM of AGNEX showed recovery as the normal control group. ROS levels were decreased in the AGNEX treated at 10-20 μM compared with the 600 μM hydrogen peroxide group. The AGNEX treated group was reduced by 20% compared with the untreated control group. This study suggests that AGNEX could prevent damage to blue light-induced retinal cells by oxidative stress relief, suggesting its potential as a therapeutic agent similar to eye care functional foods and as medicine against retinal cell damage.
蓝光等光污染会损害视觉感光器,导致细胞死亡和退行性视网膜疾病。尽管患有视网膜疾病的患者越来越多,但治疗药物仍然不足。白芷提取物(AGNEX)含有高比例的前驱素衍生物,能有效地保护氧化应激或高强度蓝光下的细胞。然而,目前还不清楚它是否能有效地保护视网膜细胞。在此,我们研究了AGNEX对活性氧(ROS)损伤视网膜细胞的细胞保护作用,活性氧通过引起氧化应激降低视网膜细胞的活力。600 μM过氧化氢处理后细胞活力低于正常对照组的70%。而40 μM AGNEX治疗组与正常对照组一样恢复。与600 μM过氧化氢组相比,10-20 μM处理AGNEX的ROS水平降低。与未治疗对照组相比,AGNEX治疗组减少了20%。这项研究表明AGNEX可以通过氧化应激缓解来防止蓝光诱导的视网膜细胞损伤,这表明它有潜力成为一种类似于眼保健功能食品的治疗剂和治疗视网膜细胞损伤的药物。
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引用次数: 0
The Personality Types and Desired Career Fields of Pharmacy Students 药学专业学生的人格类型与理想职业领域
Pub Date : 2022-06-30 DOI: 10.17480/psk.2022.66.3.140
Bangsun Choi, Hyun-Mee Joung, P. Chun
This study was conducted to investigate the personality types and most desired career fields of pharmacy students. In this study, 31 first-year students, 28 third-year transfer students, and 32 fifth-grade students were analyzed, and 60.4% were female. Of 91 subjects, the introversion-sensing-thinking-judging (ISTJ) type was the most common, followed by introversion-sensing-thinking-perceiving (ISTP) and extraversion-sensing-thinking-judging (ESTJ). Thirty-five percent of first-graders, 42.9% of third-graders, and 53.1% of fifth-graders were extroverts and 64.5% of first-graders, 71.4% of thirdgraders, and 68.8% of fifth-graders belonged to the “sensing” personality type. Seventy-one percent of first-graders, 60.7% of third-graders, and 75% of fifth-graders belonged to the “thinking” type. Of 41 students wishing to work at community pharmacies, 51.2% were extroverts, 70.7% were “sensing,” 63.4% were “thinking,” and 51.2% were the “judging” type. Of 32 students who preferred hospital pharmacy, 40.6% were extroverts, 71.9% were “sensing,” 81.3% were “thinking,” and 53.1% were the “judging” type. Of 11 students wishing to work in pharmaceuticals, 36.4% were extroverts, 63.6% were “sensing,” 63.6% were “thinking,” and 72.7% were the “perceiving” type. Of seven students who preferred public institutions, 71.4% were introverts. When analyzing the correlation between personality types and the most desired career fields, no statistical significance was observed.
本研究旨在探讨药学专业学生的人格类型与最想从事的职业领域。本研究分析了31名一年级学生、28名三年级转学生和32名五年级学生,其中60.4%为女生。91名被试中,以内向-感觉-思考-判断(ISTJ)型最常见,其次是内向-感觉-思考-感知(ISTP)型和外向-感觉-思考-判断(ESTJ)型。35%的一年级学生、42.9%的三年级学生和53.1%的五年级学生属于外向型,64.5%的一年级学生、71.4%的三年级学生和68.8%的五年级学生属于“感知型”人格类型。71%的一年级学生、60.7%的三年级学生和75%的五年级学生属于“思考型”。在41名希望在社区药房工作的学生中,51.2%是外向型,70.7%是“感知型”,63.4%是“思考型”,51.2%是“判断型”。32名偏爱医院药房的学生中,40.6%为外向型,71.9%为感性型,81.3%为思考型,53.1%为判断型。在11名希望在制药行业工作的学生中,36.4%为外向型,63.6%为“感知型”,63.6%为“思考型”,72.7%为“感知型”。在7名选择公共机构的学生中,71.4%是内向者。在分析人格类型与最想从事的职业领域之间的相关性时,没有发现有统计学意义。
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引用次数: 0
Current Trends in Causes and Mechanisms of Pruritus Induced by Systemic Diseases 全身性疾病引起的瘙痒的病因和机制的最新进展
Pub Date : 2022-06-30 DOI: 10.17480/psk.2022.66.3.115
Sohyung Park, W. Shim
Pruritus is a sensation that evokes a desire to scratch the skin. In particular, pruritus can be a burden for affected people when it becomes severe and chronic, as it deteriorates the quality of life. Dermatological diseases such as atopic dermatitis are mostly recognized as major pruritus-related disorders. Surprisingly, some non-dermatological systemic diseases can also evoke pruritus. In this review, we summarized the underlying causes and mechanisms of three nondermatological pruritus-related systemic diseases: including chronic kidney disease, cholestatic liver disease, and neoplasm. In addition, recent research observations and novel therapeutic strategies are discussed.
瘙痒症是一种让人想抓挠皮肤的感觉。特别是,当瘙痒变得严重和慢性时,它会恶化生活质量,对受影响的人来说可能是一种负担。皮肤疾病,如特应性皮炎,大多被认为是主要的瘙痒相关疾病。令人惊讶的是,一些非皮肤系统疾病也能引起瘙痒。在这篇综述中,我们总结了三种与皮肤瘙痒相关的系统性疾病的潜在原因和机制:包括慢性肾病、胆汁淤积性肝病和肿瘤。此外,还讨论了最近的研究结果和新的治疗策略。
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引用次数: 0
Public Health Emergency Preparedness and Response by Regulatory Authorities in South Korea, United States, and Europe 韩国、美国和欧洲监管当局的突发公共卫生事件准备和应对
Pub Date : 2022-06-30 DOI: 10.17480/psk.2022.66.3.125
Sunyoung Kim, Yeong-Gaung Han, EunHui Moon, SeokYeon Kang, Wongu Kang, J. Won, Si-Yeon Jeong
Since the outbreak of the new strain of coronavirus (SARS-CoV-2, COVID-19) was first reported, regulatory authorities worldwide have issued various regulatory guidelines and recommendations. Global authorities are committed to supporting developers of potential vaccines and treatments for COVID-19. This study reviewed the guidelines and regulatory procedures instituted by authorities in the United States and Europe to understand the current perspectives of regulatory agencies worldwide and derive implications for public health emergency responses. The Act on Encouragement of Development and Emergency Circulation of Medical Countermeasures for public health emergencies enacted in 2021 established the Ministry of Food and Drug Safety (MFDS) to oversee policies for public health emergencies. In the US, the Public Law 113-5, the PHS Act, the PREP Act and the FD&C Act grant authorities emergency use power with respect to medical countermeasures needed during public health emergencies. The FDA can also facilitate the use of those medical countermeasures. The EMA has accelerated regulatory procedures in place for expediting the development and approval of medicinal products for COVID-19. The EMA’s rapid procedure includes rolling review, accelerated assessment and conditional marketing authorisation. Based on the review of foreign policies and practices regarding public health emergencies, this study showed that the Act on Encouragement of Development and Emergency Circulation of Medical Countermeasures for public health emergency responses has made important advances in public health emergency preparedness and response.
自首次报道新型冠状病毒(SARS-CoV-2, COVID-19)爆发以来,世界各地的监管机构发布了各种监管指南和建议。全球有关当局致力于支持COVID-19潜在疫苗和治疗方法的开发人员。本研究回顾了美国和欧洲当局制定的指导方针和监管程序,以了解世界各地监管机构的当前观点,并得出对突发公共卫生事件应对的影响。根据2021年制定的《公共卫生紧急事件医疗对策鼓励开发和紧急流通法》,设立了食品药品安全部,负责监督公共卫生紧急事件政策。在美国,公法113-5、PHS法案、PREP法案和FD&C法案赋予当局在突发公共卫生事件中所需的医疗对策方面的紧急使用权。食品及药物管理局也可以促进这些医疗对策的使用。EMA加快了现有的监管程序,以加快COVID-19药品的开发和批准。EMA的快速程序包括滚动审查、加速评估和有条件上市许可。本研究在回顾突发公共卫生事件外交政策和实践的基础上,认为《突发公共卫生事件应对医学对策鼓励发展和应急流通法》在突发公共卫生事件的准备和应对方面取得了重要进展。
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引用次数: 0
Adverse Events Analysis and Signal Detection of Baricitinib and Tocilizumab, using KIDS-KD: Focusing on the Adverse Events that may Affect COVID-19 基于KIDS-KD的Baricitinib和Tocilizumab不良事件分析和信号检测:关注可能影响COVID-19的不良事件
Pub Date : 2022-04-30 DOI: 10.17480/psk.2022.66.2.49
Ji-Young Hur, Ju-Young Shin
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引用次数: 0
The Development of Gastro-Retentive Tablet using Hot Melt Extrusion and 3D Printing Technology 利用热熔挤压和3D打印技术研制胃保留片
Pub Date : 2022-04-30 DOI: 10.17480/psk.2022.66.2.76
S. Lee, Young ho Cho, Gye-Won Lee
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引用次数: 1
Trends in the Consumption of Anti-dementia Drugs by Region, Provider Type, and Diagnostic Code in South Korea 韩国按地区、提供者类型和诊断代码划分的抗痴呆药物消费趋势
Pub Date : 2022-04-30 DOI: 10.17480/psk.2022.66.2.58
S.Y. Chung, Hye-Jae Lee
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引用次数: 0
Effect of Hyperoside on the Gene Expression and Production of Mucin and EGFR-p44/42-Sp1signaling Pathway in Airway Epithelial Cells 金丝桃苷对气道上皮细胞黏液蛋白基因表达和产生及egfr -p44/42- sp1信号通路的影响
Pub Date : 2022-04-30 DOI: 10.17480/psk.2022.66.2.104
Hyun Jae Lee
{"title":"Effect of Hyperoside on the Gene Expression and Production of Mucin and EGFR-p44/42-Sp1signaling Pathway in Airway Epithelial Cells","authors":"Hyun Jae Lee","doi":"10.17480/psk.2022.66.2.104","DOIUrl":"https://doi.org/10.17480/psk.2022.66.2.104","url":null,"abstract":"","PeriodicalId":23923,"journal":{"name":"Yakhak Hoeji","volume":"140 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81712531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Yakhak Hoeji
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