首页 > 最新文献

中国修复重建外科杂志最新文献

英文 中文
[Effectiveness of modified single patellar tunnel medial patella femoral ligament reconstruction for recurrent patellar dislocation].
Q3 Medicine Pub Date : 2025-01-15 DOI: 10.7507/1002-1892.202409002
Guoliang Wang, Li Li, Fan Wang, Yixiang Dai, Hua Li, Qinglü Shi
<p><strong>Objective: </strong>To investigate the effectiveness of modified single patellar tunnel medial patella femoral ligament (MPFL) reconstruction in the treatment of recurrent patellar dislocation.</p><p><strong>Methods: </strong>Between January 2023 and June 2023, a total of 61 patients with recurrent patellar dislocation who underwent MPFL reconstruction with autologous semitendinosus were enrolled and divided into 2 groups using random number table method. In the patellar anchor group, 31 patients were treated with MPFL reconstruction with double medial patellar anchors, and 30 patients in the patellar tunnel group were treated with MPFL reconstruction with single patellar tunnel. The femoral ends of both groups were fixed with absorbable compression screws. There was no significant difference in baseline data such as gender, age, side, tibial tubercle-trochlear groove (TT-TG), Q angle, Caton-Deschamps index, number of dislocation, and preoperative Kujala score, preoperative patellar inclination angle ( <i>P</i>>0.05). Patellar tunnel, patellar anchor position, patellar reduction, and the patellar inclination angle were measured by CT scan after operation. Kujala score was used to evaluate the function of knee joint before operation, at 2 weeks and 1, 3, 6, 12 months after operation. Incision aesthetic satisfaction score was performed at 3 months after operation. The signal-to-noise quotient (SNQ) of the transplanted tendon was measured by knee MRI at 12 months after operation to compare the maturity of the graft between the two groups.</p><p><strong>Results: </strong>There was no significant difference in operation time and intraoperative blood loss between the two groups ( <i>P</i>>0.05). Knee CT reexamination showed that the patellar tunnel and the patellar anchor position were consistent with the intraoperative fluoroscopy. There was no significant difference in the difference of the patellar inclination angle between the two groups before and after operation ( <i>P</i>>0.05). All patients were followed up 12-14 months (mean, 12.8 months). There was 1 case of patellar anchor suture rejection in patellar anchor group, and the wound healed after debridement and dressing change. During the follow-up, there was no complication such as recurrence of patellar dislocation, infection and postoperative stiffness. The Kujala scores of the two groups significantly improved at each time point after 1 month of operation when compared with those before operation ( <i>P</i><0.05), and the Kujala scores of the two groups returned to normal levels at 3 months after operation. The Kujala score in the patellar tunnel group was significantly higher than that in the patellar anchor group in the very early stage (2 weeks) ( <i>P</i><0.05), and there was no significant difference between the two groups at other time points ( <i>P</i>>0.05). Patients in the patellar tunnel group were significantly better than those in the patellar anchor group in the score
{"title":"[Effectiveness of modified single patellar tunnel medial patella femoral ligament reconstruction for recurrent patellar dislocation].","authors":"Guoliang Wang, Li Li, Fan Wang, Yixiang Dai, Hua Li, Qinglü Shi","doi":"10.7507/1002-1892.202409002","DOIUrl":"10.7507/1002-1892.202409002","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the effectiveness of modified single patellar tunnel medial patella femoral ligament (MPFL) reconstruction in the treatment of recurrent patellar dislocation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Between January 2023 and June 2023, a total of 61 patients with recurrent patellar dislocation who underwent MPFL reconstruction with autologous semitendinosus were enrolled and divided into 2 groups using random number table method. In the patellar anchor group, 31 patients were treated with MPFL reconstruction with double medial patellar anchors, and 30 patients in the patellar tunnel group were treated with MPFL reconstruction with single patellar tunnel. The femoral ends of both groups were fixed with absorbable compression screws. There was no significant difference in baseline data such as gender, age, side, tibial tubercle-trochlear groove (TT-TG), Q angle, Caton-Deschamps index, number of dislocation, and preoperative Kujala score, preoperative patellar inclination angle ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). Patellar tunnel, patellar anchor position, patellar reduction, and the patellar inclination angle were measured by CT scan after operation. Kujala score was used to evaluate the function of knee joint before operation, at 2 weeks and 1, 3, 6, 12 months after operation. Incision aesthetic satisfaction score was performed at 3 months after operation. The signal-to-noise quotient (SNQ) of the transplanted tendon was measured by knee MRI at 12 months after operation to compare the maturity of the graft between the two groups.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;There was no significant difference in operation time and intraoperative blood loss between the two groups ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). Knee CT reexamination showed that the patellar tunnel and the patellar anchor position were consistent with the intraoperative fluoroscopy. There was no significant difference in the difference of the patellar inclination angle between the two groups before and after operation ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). All patients were followed up 12-14 months (mean, 12.8 months). There was 1 case of patellar anchor suture rejection in patellar anchor group, and the wound healed after debridement and dressing change. During the follow-up, there was no complication such as recurrence of patellar dislocation, infection and postoperative stiffness. The Kujala scores of the two groups significantly improved at each time point after 1 month of operation when compared with those before operation ( &lt;i&gt;P&lt;/i&gt;&lt;0.05), and the Kujala scores of the two groups returned to normal levels at 3 months after operation. The Kujala score in the patellar tunnel group was significantly higher than that in the patellar anchor group in the very early stage (2 weeks) ( &lt;i&gt;P&lt;/i&gt;&lt;0.05), and there was no significant difference between the two groups at other time points ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). Patients in the patellar tunnel group were significantly better than those in the patellar anchor group in the score","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"39 1","pages":"20-25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Application of elbow skin fold extension line in extreme elbow flexion in ulnar Kirschner wire insertion of extended supracondylar humeral fractures in children].
Q3 Medicine Pub Date : 2025-01-15 DOI: 10.7507/1002-1892.202409088
Xu Liu, Wei Wu, Yuzhou Shan, Guanghui Yang, Ming Chen
<p><strong>Objective: </strong>To discuss the elbow skin fold extension line in Kirschner wire internal fixation of extended supracondylar humeral fractures in children.</p><p><strong>Methods: </strong>The clinical data of 58 children with extended supracondylar fractures of the humerus who met the selection criteria between August 2021 and July 2024 were retrospectively analyzed. In 28 cases, needle placement of medial epicondyle of humerus was performed with the assistance of the elbow skin fold extension line (study group), and 30 cases were assisted by routine touch of the medial epicondyle of the humerus (control group). There was no significant difference in baseline data such as gender, age, side, cause of injury, Gartland type, Kirschner wire configuration, and time from injury to operation between the two groups ( <i>P</i>>0.05). The closed reduction rate, total operation time, time of medial humeral condyle pin placement, fluoroscopy times during medial pin placement, rate of one-time determination of medial entry point, ulnar nerve injury incidence, and fracture healing time were recorded and compared between the two groups. At the same time, the closed reduction rate of patients with the time from injury to operation ≤24 hours and >24 hours was compared. The elbow function was evaluated by Mayo elbow function score.</p><p><strong>Results: </strong>The closed reduction rate of the study group was significantly higher than that of the control group ( <i>P</i><0.05). Among all patients, the closed reduction rate of patients with the time from injury to operation ≤24 hours [73.3% (22/30)] was significantly higher than that of patients >24 hours [42.9% (12/28)] ( <i>χ</i> <sup>2</sup>=5.545, <i>P</i>=0.019). The total operation time, medial needle placement time, and fluoroscopy times in the study group were significantly less than those in the control group, and the one-time determination rate of medial needle entry point in the study group was significantly higher than that in the control group ( <i>P</i><0.05). There were 4 cases of ulnar nerve injury in the control group, and no ulnar nerve injury in the study group, but there was no significant difference in the incidence of ulnar nerve injury between the two groups ( <i>P</i>>0.05). All patients were followed up 6-12 months (mean, 8 months). There was no bone nonunion in both groups, and the fracture healing time of the study group was significantly shorter than that of the control group ( <i>P</i><0.05). Volkmann ischemic contracture, heterotopic ossification, myositis ossificans, and premature epiphyseal closure were not observed after operation. No complications such as loosening or fracture of Kirschner wire occurred. At last follow-up, the Mayo elbow joint function score was used to evaluate function, and there was no significant difference between the two groups ( <i>P</i>>0.05).</p><p><strong>Conclusion: </strong>In the treatment of extended supracondylar fractures of the hume
{"title":"[Application of elbow skin fold extension line in extreme elbow flexion in ulnar Kirschner wire insertion of extended supracondylar humeral fractures in children].","authors":"Xu Liu, Wei Wu, Yuzhou Shan, Guanghui Yang, Ming Chen","doi":"10.7507/1002-1892.202409088","DOIUrl":"10.7507/1002-1892.202409088","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To discuss the elbow skin fold extension line in Kirschner wire internal fixation of extended supracondylar humeral fractures in children.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The clinical data of 58 children with extended supracondylar fractures of the humerus who met the selection criteria between August 2021 and July 2024 were retrospectively analyzed. In 28 cases, needle placement of medial epicondyle of humerus was performed with the assistance of the elbow skin fold extension line (study group), and 30 cases were assisted by routine touch of the medial epicondyle of the humerus (control group). There was no significant difference in baseline data such as gender, age, side, cause of injury, Gartland type, Kirschner wire configuration, and time from injury to operation between the two groups ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). The closed reduction rate, total operation time, time of medial humeral condyle pin placement, fluoroscopy times during medial pin placement, rate of one-time determination of medial entry point, ulnar nerve injury incidence, and fracture healing time were recorded and compared between the two groups. At the same time, the closed reduction rate of patients with the time from injury to operation ≤24 hours and &gt;24 hours was compared. The elbow function was evaluated by Mayo elbow function score.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The closed reduction rate of the study group was significantly higher than that of the control group ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). Among all patients, the closed reduction rate of patients with the time from injury to operation ≤24 hours [73.3% (22/30)] was significantly higher than that of patients &gt;24 hours [42.9% (12/28)] ( &lt;i&gt;χ&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt;=5.545, &lt;i&gt;P&lt;/i&gt;=0.019). The total operation time, medial needle placement time, and fluoroscopy times in the study group were significantly less than those in the control group, and the one-time determination rate of medial needle entry point in the study group was significantly higher than that in the control group ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). There were 4 cases of ulnar nerve injury in the control group, and no ulnar nerve injury in the study group, but there was no significant difference in the incidence of ulnar nerve injury between the two groups ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). All patients were followed up 6-12 months (mean, 8 months). There was no bone nonunion in both groups, and the fracture healing time of the study group was significantly shorter than that of the control group ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). Volkmann ischemic contracture, heterotopic ossification, myositis ossificans, and premature epiphyseal closure were not observed after operation. No complications such as loosening or fracture of Kirschner wire occurred. At last follow-up, the Mayo elbow joint function score was used to evaluate function, and there was no significant difference between the two groups ( &lt;i&gt;P&lt;/i&gt;&gt;0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;In the treatment of extended supracondylar fractures of the hume","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"39 1","pages":"70-74"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Applications and prospects of graphene and its derivatives in bone repair].
Q3 Medicine Pub Date : 2025-01-15 DOI: 10.7507/1002-1892.202410011
Zhipo Du, Yizhan Ma, Cunyang Wang, Ruihong Zhang, Xiaoming Li

Objective: To summarize the latest research progress of graphene and its derivatives (GDs) in bone repair.

Methods: The relevant research literature at home and abroad in recent years was extensively accessed. The properties of GDs in bone repair materials, including mechanical properties, electrical conductivity, and antibacterial properties, were systematically summarized, and the unique advantages of GDs in material preparation, functionalization, and application, as well as the contributions and challenges to bone tissue engineering, were discussed.

Results: The application of GDs in bone repair materials has broad prospects, and the functionalization and modification technology effectively improve the osteogenic activity and material properties of GDs. GDs can induce osteogenic differentiation of stem cells through specific signaling pathways and promote osteogenic activity through immunomodulatory mechanisms. In addition, the parameters of GDs have significant effects on the cytotoxicity and degradation behavior.

Conclusion: GDs has great potential in the field of bone repair because of its excellent physical and chemical properties and biological properties. However, the cytotoxicity, biodegradability, and functionalization strategies of GDs still need to be further studied in order to achieve a wider application in the field of bone tissue engineering.

{"title":"[Applications and prospects of graphene and its derivatives in bone repair].","authors":"Zhipo Du, Yizhan Ma, Cunyang Wang, Ruihong Zhang, Xiaoming Li","doi":"10.7507/1002-1892.202410011","DOIUrl":"10.7507/1002-1892.202410011","url":null,"abstract":"<p><strong>Objective: </strong>To summarize the latest research progress of graphene and its derivatives (GDs) in bone repair.</p><p><strong>Methods: </strong>The relevant research literature at home and abroad in recent years was extensively accessed. The properties of GDs in bone repair materials, including mechanical properties, electrical conductivity, and antibacterial properties, were systematically summarized, and the unique advantages of GDs in material preparation, functionalization, and application, as well as the contributions and challenges to bone tissue engineering, were discussed.</p><p><strong>Results: </strong>The application of GDs in bone repair materials has broad prospects, and the functionalization and modification technology effectively improve the osteogenic activity and material properties of GDs. GDs can induce osteogenic differentiation of stem cells through specific signaling pathways and promote osteogenic activity through immunomodulatory mechanisms. In addition, the parameters of GDs have significant effects on the cytotoxicity and degradation behavior.</p><p><strong>Conclusion: </strong>GDs has great potential in the field of bone repair because of its excellent physical and chemical properties and biological properties. However, the cytotoxicity, biodegradability, and functionalization strategies of GDs still need to be further studied in order to achieve a wider application in the field of bone tissue engineering.</p>","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"39 1","pages":"106-117"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Comparison of effectiveness between two surgical methods for humeral lateral condyle fractures in children].
Q3 Medicine Pub Date : 2025-01-15 DOI: 10.7507/1002-1892.202410046
Hailong Ma, Qingjie Wu, Fang Liu, Zhongtuo Hua, Sicheng Zhang

Objective: To compare the effectiveness of ultrasound-guided closed reduction with Kirschner wire fixation and open reduction with Kirschner wire fixation in the treatment of humeral lateral condyle fracture (HLCF) in children.

Methods: A clinical data of 53 children with HLCF admitted between May 2020 and April 2023 and met selective criteria was retrospectively analyzed. Of these, 25 cases were managed with closed reduction and Kirschner wire fixation under ultrasound guidance (closed group), while 28 cases underwent open reduction and Kirschner wire fixation (open group). There was no significant difference between the two groups in terms of gender, age, cause of injury, fracture side, fracture classification, and time from injury to operation ( P>0.05). The following variables were recorded and compared between the two groups: operation time, intraoperative fluoroscopy frequency, fracture healing time, incidence of complications, and the Flynn elbow function score at last follow-up.

Results: In the closed group, the fractures were successfully reduced under ultrasound guidance, with no nerve damage reported in either group. The operation time and intraoperative fluoroscopy frequency were significantly less in the closed group than in the open group ( P<0.05). One case of infection (Kirschner wire irritation) was observed in the closed group, while 3 cases in the open group (2 of Kirschner wire irritation and 1 of incision infection). However, the difference in the incidence of infection between the two groups was not significant ( P>0.05). All patients in both groups were followed up 6-18 months (mean, 10.2 months). X-ray examinations confirmed that fractures had healed in both groups, with no significant difference in healing time ( P>0.05). During follow-up, 5 cases of lateral humeral process formation were observed in the closed group, compared to 12 cases in the open group, although this difference was not significant ( P>0.05). At last follow-up, the excellent and good rate of elbow joint function was evaluated as 96.0% (24/25) in the closed group and 92.9% (26/28) in the open group according to the Flynn scoring criteria, with no significant difference between the two groups ( P>0.05). Both groups showed no occurrence of ossifying myositis or elbow internal/external rotation.

Conclusion: The effectiveness of ultrasound-guided closed reduction and Kirschner wire fixation in the treatment of HLCF in children is comparable to open reduction and Kirschner wire fixation, but the former can reduce operation time and intraoperative fluoroscopy frequency, and obtain lower the incidence of complications.

{"title":"[Comparison of effectiveness between two surgical methods for humeral lateral condyle fractures in children].","authors":"Hailong Ma, Qingjie Wu, Fang Liu, Zhongtuo Hua, Sicheng Zhang","doi":"10.7507/1002-1892.202410046","DOIUrl":"10.7507/1002-1892.202410046","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effectiveness of ultrasound-guided closed reduction with Kirschner wire fixation and open reduction with Kirschner wire fixation in the treatment of humeral lateral condyle fracture (HLCF) in children.</p><p><strong>Methods: </strong>A clinical data of 53 children with HLCF admitted between May 2020 and April 2023 and met selective criteria was retrospectively analyzed. Of these, 25 cases were managed with closed reduction and Kirschner wire fixation under ultrasound guidance (closed group), while 28 cases underwent open reduction and Kirschner wire fixation (open group). There was no significant difference between the two groups in terms of gender, age, cause of injury, fracture side, fracture classification, and time from injury to operation ( <i>P</i>>0.05). The following variables were recorded and compared between the two groups: operation time, intraoperative fluoroscopy frequency, fracture healing time, incidence of complications, and the Flynn elbow function score at last follow-up.</p><p><strong>Results: </strong>In the closed group, the fractures were successfully reduced under ultrasound guidance, with no nerve damage reported in either group. The operation time and intraoperative fluoroscopy frequency were significantly less in the closed group than in the open group ( <i>P</i><0.05). One case of infection (Kirschner wire irritation) was observed in the closed group, while 3 cases in the open group (2 of Kirschner wire irritation and 1 of incision infection). However, the difference in the incidence of infection between the two groups was not significant ( <i>P</i>>0.05). All patients in both groups were followed up 6-18 months (mean, 10.2 months). X-ray examinations confirmed that fractures had healed in both groups, with no significant difference in healing time ( <i>P</i>>0.05). During follow-up, 5 cases of lateral humeral process formation were observed in the closed group, compared to 12 cases in the open group, although this difference was not significant ( <i>P</i>>0.05). At last follow-up, the excellent and good rate of elbow joint function was evaluated as 96.0% (24/25) in the closed group and 92.9% (26/28) in the open group according to the Flynn scoring criteria, with no significant difference between the two groups ( <i>P</i>>0.05). Both groups showed no occurrence of ossifying myositis or elbow internal/external rotation.</p><p><strong>Conclusion: </strong>The effectiveness of ultrasound-guided closed reduction and Kirschner wire fixation in the treatment of HLCF in children is comparable to open reduction and Kirschner wire fixation, but the former can reduce operation time and intraoperative fluoroscopy frequency, and obtain lower the incidence of complications.</p>","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"39 1","pages":"64-69"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research progress of bioactive scaffolds in repair and regeneration of osteoporotic bone defects].
Q3 Medicine Pub Date : 2025-01-15 DOI: 10.7507/1002-1892.202410018
Yuangang Wu, Kaibo Sun, Yi Zeng, Bin Shen

Objective: To summarize the research progress of bioactive scaffolds in the repair and regeneration of osteoporotic bone defects.

Methods: Recent literature on bioactive scaffolds for the repair of osteoporotic bone defects was reviewed to summarize various types of bioactive scaffolds and their associated repair methods.

Results: The application of bioactive scaffolds provides a new idea for the repair and regeneration of osteoporotic bone defects. For example, calcium phosphate ceramics scaffolds, hydrogel scaffolds, three-dimensional (3D)-printed biological scaffolds, metal scaffolds, as well as polymer material scaffolds and bone organoids, have all demonstrated good bone repair-promoting effects. However, in the pathological bone microenvironment of osteoporosis, the function of single-material scaffolds to promote bone regeneration is insufficient. Therefore, the design of bioactive scaffolds must consider multiple factors, including material biocompatibility, mechanical properties, bioactivity, bone conductivity, and osteogenic induction. Furthermore, physical and chemical surface modifications, along with advanced biotechnological approaches, can help to improve the osteogenic microenvironment and promote the differentiation of bone cells.

Conclusion: With advancements in technology, the synergistic application of 3D bioprinting, bone organoids technologies, and advanced biotechnologies holds promise for providing more efficient bioactive scaffolds for the repair and regeneration of osteoporotic bone defects.

{"title":"[Research progress of bioactive scaffolds in repair and regeneration of osteoporotic bone defects].","authors":"Yuangang Wu, Kaibo Sun, Yi Zeng, Bin Shen","doi":"10.7507/1002-1892.202410018","DOIUrl":"10.7507/1002-1892.202410018","url":null,"abstract":"<p><strong>Objective: </strong>To summarize the research progress of bioactive scaffolds in the repair and regeneration of osteoporotic bone defects.</p><p><strong>Methods: </strong>Recent literature on bioactive scaffolds for the repair of osteoporotic bone defects was reviewed to summarize various types of bioactive scaffolds and their associated repair methods.</p><p><strong>Results: </strong>The application of bioactive scaffolds provides a new idea for the repair and regeneration of osteoporotic bone defects. For example, calcium phosphate ceramics scaffolds, hydrogel scaffolds, three-dimensional (3D)-printed biological scaffolds, metal scaffolds, as well as polymer material scaffolds and bone organoids, have all demonstrated good bone repair-promoting effects. However, in the pathological bone microenvironment of osteoporosis, the function of single-material scaffolds to promote bone regeneration is insufficient. Therefore, the design of bioactive scaffolds must consider multiple factors, including material biocompatibility, mechanical properties, bioactivity, bone conductivity, and osteogenic induction. Furthermore, physical and chemical surface modifications, along with advanced biotechnological approaches, can help to improve the osteogenic microenvironment and promote the differentiation of bone cells.</p><p><strong>Conclusion: </strong>With advancements in technology, the synergistic application of 3D bioprinting, bone organoids technologies, and advanced biotechnologies holds promise for providing more efficient bioactive scaffolds for the repair and regeneration of osteoporotic bone defects.</p>","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"39 1","pages":"100-105"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Three-dimensional binding treatment for avulsion fractures of inferior pole of patella utilizing suture anchor].
Q3 Medicine Pub Date : 2025-01-15 DOI: 10.7507/1002-1892.202409080
Hongqing He, Ningkai Li, Meng Liu, Jiating Lin, Qiang Wang, Yinchang Zhang

Objective: To explore the feasibility and effectiveness of suture anchor double-pulley technique combined with suture three-dimensional binding via bone tunnel technique for avulsion fractures of the inferior pole of the patella.

Methods: A clinical data of 38 patients with avulsion fractures of the inferior pole of the patella, who met the selective criteria and were admitted between September 2021 and April 2023, was retrospectively analyzed. The fractures were treated with suture anchor double-pulley technique combined with suture three-dimensional binding via bone tunnel technique in 18 cases (group A) and steel wire tension-band fixation in 20 cases (group B). There was no significant difference in terms of age, gender, cause of fracture, side of fracture, and disease duration between the two groups ( P>0.05). The length of incision, operation time, occurrence of complications, the range of motion of knee joint, and Böstman score of knee joint at last follow-up were recorded. The fracture healing was evaluated through X-ray films and the time of fracture healing was recorded.

Results: All incisions healed by first intention. The length of incision was significantly shorter in group A than in group B ( P<0.05). There was no significant difference in the operation time between the two groups ( P>0.05). All patients were followed up 12-24 months (mean, 16.1 months). X-ray films showed that all fractures healed and there was no significant difference in the healing time between the two groups ( P>0.05). At last follow-up, the range of motion and Böstman score of the knee joint in group A were significantly better than those in group B ( P<0.05). During follow-up, 1 patient (5.6%) in group A had one anchor mild prolapse and 3 patients (15.0%) occured internal fixation irritation in group B. But there was no significant difference in the incidence of complications between the two groups ( P>0.05).

Conclusion: For the avulsion fractures of the inferior pole of the patella, the suture anchor double-pulley technique combined with suture three-dimensional binding via bone tunnel technique has advantages of reliable fixation, small incision, avoidance of secondary operation to remove internal fixator, and fewer complications, with definite effectiveness.

{"title":"[Three-dimensional binding treatment for avulsion fractures of inferior pole of patella utilizing suture anchor].","authors":"Hongqing He, Ningkai Li, Meng Liu, Jiating Lin, Qiang Wang, Yinchang Zhang","doi":"10.7507/1002-1892.202409080","DOIUrl":"10.7507/1002-1892.202409080","url":null,"abstract":"<p><strong>Objective: </strong>To explore the feasibility and effectiveness of suture anchor double-pulley technique combined with suture three-dimensional binding via bone tunnel technique for avulsion fractures of the inferior pole of the patella.</p><p><strong>Methods: </strong>A clinical data of 38 patients with avulsion fractures of the inferior pole of the patella, who met the selective criteria and were admitted between September 2021 and April 2023, was retrospectively analyzed. The fractures were treated with suture anchor double-pulley technique combined with suture three-dimensional binding via bone tunnel technique in 18 cases (group A) and steel wire tension-band fixation in 20 cases (group B). There was no significant difference in terms of age, gender, cause of fracture, side of fracture, and disease duration between the two groups ( <i>P</i>>0.05). The length of incision, operation time, occurrence of complications, the range of motion of knee joint, and Böstman score of knee joint at last follow-up were recorded. The fracture healing was evaluated through X-ray films and the time of fracture healing was recorded.</p><p><strong>Results: </strong>All incisions healed by first intention. The length of incision was significantly shorter in group A than in group B ( <i>P</i><0.05). There was no significant difference in the operation time between the two groups ( <i>P</i>>0.05). All patients were followed up 12-24 months (mean, 16.1 months). X-ray films showed that all fractures healed and there was no significant difference in the healing time between the two groups ( <i>P</i>>0.05). At last follow-up, the range of motion and Böstman score of the knee joint in group A were significantly better than those in group B ( <i>P</i><0.05). During follow-up, 1 patient (5.6%) in group A had one anchor mild prolapse and 3 patients (15.0%) occured internal fixation irritation in group B. But there was no significant difference in the incidence of complications between the two groups ( <i>P</i>>0.05).</p><p><strong>Conclusion: </strong>For the avulsion fractures of the inferior pole of the patella, the suture anchor double-pulley technique combined with suture three-dimensional binding via bone tunnel technique has advantages of reliable fixation, small incision, avoidance of secondary operation to remove internal fixator, and fewer complications, with definite effectiveness.</p>","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"39 1","pages":"26-31"},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Observation of analgesic efficacy of liposomal bupivacaine for local infiltration anesthesia in unicompartmental knee arthroplasty: a prospective randomized controlled study]. [布比卡因脂质体用于单室膝关节置换术局部浸润麻醉的镇痛效果观察:一项前瞻性随机对照研究]。
Q3 Medicine Pub Date : 2024-12-15 DOI: 10.7507/1002-1892.202408085
Shanbin Zheng, Hongyu Hu, Tianwei Xia, Liansheng Shao, Jiaqing Zhu, Jiahao Sun, Bowen Ma, Chiyu Zhang, Libing Huang, Xun Cao, Zhiyuan Chen, Chao Zhang, Jirong Shen
<p><strong>Objective: </strong>A prospective randomized controlled study was conducted to investigate the early postoperative analgesic effectiveness of using liposomal bupivacaine (LB) for local infiltration anesthesia (LIA) in unicompartmental knee arthroplasty (UKA).</p><p><strong>Methods: </strong>Between January 2024 and July 2024, a total of 80 patients with knee osteoarthritis (KOA) who met the selection criteria were enrolled in the study. Patients were randomly assigned to either the LB group or the "cocktail" group in a 1∶1 ratio using a random number table, with 40 patients in each group. Baseline characteristics, including gender, age, body mass index, operated side, Kellgren-Lawrence grade, and preoperative American Society of Anesthesiologists (ASA) classification, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and knee joint range of motion, showed no significant difference between the two groups ( <i>P</i>>0.05). Both groups received LIA and comprehensive pain management. The surgical duration, incision length, pain-related indicators [resting and activity visual analogue scale (VAS) scores, total dosage of oral morphine, WOMAC scores], knee joint range of motion, first ambulation time after operation, length of hospital stay, and postoperative adverse events.</p><p><strong>Results: </strong>There was no significant difference between the two groups in surgical duration, incision length, first ambulation time after operation, length of hospital stay, total dosage of oral morphine, and pre-discharge satisfaction with surgery and WOMAC scores ( <i>P</i>>0.05). At 4, 12, and 24 hours after operation, the resting and activity VAS scores in the "cocktail" group were lower than those in the LB group; at 60 and 72 hours postoperatively, the resting VAS scores in the LB group were lower than those in the "cocktail" group, with the activity VAS scores also being lower at 60 hours; all showing significant differences ( <i>P</i><0.05). There was no significant difference in the above indicators between the two groups at other time points ( <i>P</i>>0.05). On the second postoperative day, the sleep scores of the LB group were significantly higher than those of the "cocktail" group ( <i>P</i><0.05), while there was no significant difference in sleep scores on the day of surgery and the first postoperative day ( <i>P</i>>0.05). Additionally, the incidence of complications showed no significant difference between the two groups ( <i>P</i>>0.05).</p><p><strong>Conclusion: </strong>The use of LB for LIA in UKA can provide prolonged postoperative pain relief; however, it does not demonstrate a significant advantage over the "cocktail" method in terms of short-term analgesic effects or reducing opioid consumption and early functional recovery after UKA. Nevertheless, LB may help reduce postoperative sleep disturbances, making it a recommended option for UKA patients with cardiovascular diseases and insomnia or other me
目的:通过前瞻性随机对照研究,探讨布比卡因(LB)脂质体局部浸润麻醉(LIA)在单室膝关节置换术(UKA)术后早期的镇痛效果。方法:在2024年1月至2024年7月期间,共有80例符合选择标准的膝骨关节炎(KOA)患者入组研究。采用随机数字表法将患者按1∶1的比例随机分为LB组和“鸡尾酒”组,每组40例。基线特征包括性别、年龄、体重指数、手术部位、kellgreen - lawrence分级、术前美国麻醉医师学会(ASA)分级、Western Ontario and McMaster Universities Osteoarthritis index (WOMAC)评分、膝关节活动范围,两组间差异均无统计学意义(P < 0.05)。两组均接受LIA和综合疼痛管理。手术时间、切口长度、疼痛相关指标[静息与活动视觉模拟评分(VAS)评分、口服吗啡总剂量、WOMAC评分]、膝关节活动度、术后首次下床时间、住院时间、术后不良事件。结果:两组患者手术时间、切口长度、术后首次下床时间、住院时间、口服吗啡总剂量、出院前手术满意度及WOMAC评分比较,差异均无统计学意义(P < 0.05)。术后4、12、24 h,“鸡尾酒”组静息、活动VAS评分均低于LB组;术后60、72小时,LB组静息VAS评分低于“鸡尾酒”组,60小时活动VAS评分也低于“鸡尾酒”组;差异均有统计学意义(p < 0.05)。术后第2天,LB组睡眠评分显著高于“鸡尾酒”组(p < 0.05)。两组并发症发生率比较,差异无统计学意义(P < 0.05)。结论:在UKA中使用LB治疗LIA可延长术后疼痛缓解时间;然而,在短期镇痛效果或减少阿片类药物消耗和UKA后早期功能恢复方面,它并没有表现出明显优于“鸡尾酒”方法的优势。然而,LB可能有助于减少术后睡眠障碍,使其成为有心血管疾病、失眠或其他精神健康问题的UKA患者的推荐选择。
{"title":"[Observation of analgesic efficacy of liposomal bupivacaine for local infiltration anesthesia in unicompartmental knee arthroplasty: a prospective randomized controlled study].","authors":"Shanbin Zheng, Hongyu Hu, Tianwei Xia, Liansheng Shao, Jiaqing Zhu, Jiahao Sun, Bowen Ma, Chiyu Zhang, Libing Huang, Xun Cao, Zhiyuan Chen, Chao Zhang, Jirong Shen","doi":"10.7507/1002-1892.202408085","DOIUrl":"10.7507/1002-1892.202408085","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;A prospective randomized controlled study was conducted to investigate the early postoperative analgesic effectiveness of using liposomal bupivacaine (LB) for local infiltration anesthesia (LIA) in unicompartmental knee arthroplasty (UKA).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Between January 2024 and July 2024, a total of 80 patients with knee osteoarthritis (KOA) who met the selection criteria were enrolled in the study. Patients were randomly assigned to either the LB group or the \"cocktail\" group in a 1∶1 ratio using a random number table, with 40 patients in each group. Baseline characteristics, including gender, age, body mass index, operated side, Kellgren-Lawrence grade, and preoperative American Society of Anesthesiologists (ASA) classification, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score, and knee joint range of motion, showed no significant difference between the two groups ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). Both groups received LIA and comprehensive pain management. The surgical duration, incision length, pain-related indicators [resting and activity visual analogue scale (VAS) scores, total dosage of oral morphine, WOMAC scores], knee joint range of motion, first ambulation time after operation, length of hospital stay, and postoperative adverse events.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;There was no significant difference between the two groups in surgical duration, incision length, first ambulation time after operation, length of hospital stay, total dosage of oral morphine, and pre-discharge satisfaction with surgery and WOMAC scores ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). At 4, 12, and 24 hours after operation, the resting and activity VAS scores in the \"cocktail\" group were lower than those in the LB group; at 60 and 72 hours postoperatively, the resting VAS scores in the LB group were lower than those in the \"cocktail\" group, with the activity VAS scores also being lower at 60 hours; all showing significant differences ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). There was no significant difference in the above indicators between the two groups at other time points ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). On the second postoperative day, the sleep scores of the LB group were significantly higher than those of the \"cocktail\" group ( &lt;i&gt;P&lt;/i&gt;&lt;0.05), while there was no significant difference in sleep scores on the day of surgery and the first postoperative day ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). Additionally, the incidence of complications showed no significant difference between the two groups ( &lt;i&gt;P&lt;/i&gt;&gt;0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The use of LB for LIA in UKA can provide prolonged postoperative pain relief; however, it does not demonstrate a significant advantage over the \"cocktail\" method in terms of short-term analgesic effects or reducing opioid consumption and early functional recovery after UKA. Nevertheless, LB may help reduce postoperative sleep disturbances, making it a recommended option for UKA patients with cardiovascular diseases and insomnia or other me","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"38 12","pages":"1458-1465"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research progress in Cup-cage reconstruction for patients with chronic pelvic discontinuity after total hip arthroplasty]. 【全髋关节置换术后慢性盆腔不连续的Cup-cage重建研究进展】。
Q3 Medicine Pub Date : 2024-12-15 DOI: 10.7507/1002-1892.202408064
Xingxiao Pu, Qiuru Wang, Qianhao Li, Lijun Cai, Guangtao Han, Pengde Kang

Objective: To summarize research progress on application of Cup-cage reconstruction in revision of chronic pelvic discontinuity (CPD) in patients undergoing total hip arthroplasty (THA).

Methods: Relevant literature at home and abroad in recent years was reviewed to summarize the principles of the Cup-cage reconstruction, preoperative patient assessment, intraoperative skills, clinical and radiological effectiveness, limitations, and postoperative complications.

Results: For the treatment of CPD, the Cup-cage reconstruction achieved long-term acetabular cup bone ingrowth, CPD healing, and biologic fixation of the prosthesis by restoring pelvic continuity. Preoperative evaluation of the surgical site and general condition is necessary. The main intraoperative objectives are to reconstruct pelvic continuity, restore the center of rotation of the hip, and avoid neurovascular injury. Current studies have demonstrated significant clinical and radiological effectiveness as well as acceptable prosthesis survival rates after operation. Nevertheless, there is a lack of evidence regarding the staging of CPD, the optimal surgical approach and internal fixation, and the factors influencing postoperative prosthesis survival remain undefined.

Conclusion: Cup-cage reconstruction can be an effective treatment for CPD after THA, but there is still a need to explore CPD staging, Cup-cage approach and internal fixation, and influencing factors on prosthesis survival.

目的:总结杯笼重建在全髋关节置换术(THA)患者慢性盆腔不连续(CPD)修复中的应用研究进展。方法:回顾近年来国内外相关文献,总结杯笼重建的原理、术前患者评估、术中技巧、临床及影像学效果、局限性及术后并发症。结果:对于CPD的治疗,cup -cage重建术通过恢复骨盆连续性实现了髋臼杯骨长入、CPD愈合和假体的生物固定。术前评估手术部位和一般情况是必要的。术中主要目的是重建骨盆连续性,恢复髋关节旋转中心,避免神经血管损伤。目前的研究已经证明了显著的临床和放射学效果以及手术后可接受的假体存活率。然而,关于CPD的分期、最佳手术入路和内固定以及影响术后假体存活的因素仍缺乏证据。结论:杯笼重建术是THA术后CPD的有效治疗方法,但仍需对CPD的分期、杯笼入路及内固定、影响假体存活的因素进行探讨。
{"title":"[Research progress in Cup-cage reconstruction for patients with chronic pelvic discontinuity after total hip arthroplasty].","authors":"Xingxiao Pu, Qiuru Wang, Qianhao Li, Lijun Cai, Guangtao Han, Pengde Kang","doi":"10.7507/1002-1892.202408064","DOIUrl":"10.7507/1002-1892.202408064","url":null,"abstract":"<p><strong>Objective: </strong>To summarize research progress on application of Cup-cage reconstruction in revision of chronic pelvic discontinuity (CPD) in patients undergoing total hip arthroplasty (THA).</p><p><strong>Methods: </strong>Relevant literature at home and abroad in recent years was reviewed to summarize the principles of the Cup-cage reconstruction, preoperative patient assessment, intraoperative skills, clinical and radiological effectiveness, limitations, and postoperative complications.</p><p><strong>Results: </strong>For the treatment of CPD, the Cup-cage reconstruction achieved long-term acetabular cup bone ingrowth, CPD healing, and biologic fixation of the prosthesis by restoring pelvic continuity. Preoperative evaluation of the surgical site and general condition is necessary. The main intraoperative objectives are to reconstruct pelvic continuity, restore the center of rotation of the hip, and avoid neurovascular injury. Current studies have demonstrated significant clinical and radiological effectiveness as well as acceptable prosthesis survival rates after operation. Nevertheless, there is a lack of evidence regarding the staging of CPD, the optimal surgical approach and internal fixation, and the factors influencing postoperative prosthesis survival remain undefined.</p><p><strong>Conclusion: </strong>Cup-cage reconstruction can be an effective treatment for CPD after THA, but there is still a need to explore CPD staging, Cup-cage approach and internal fixation, and influencing factors on prosthesis survival.</p>","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"38 12","pages":"1530-1536"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research progress on the role of dendritic cells in immune metabolism of rheumatoid arthritis]. 树突状细胞在类风湿关节炎免疫代谢中的作用研究进展
Q3 Medicine Pub Date : 2024-12-15 DOI: 10.7507/1002-1892.202408002
Guangtao Han, Shuo Sun, Qin Wang, Pengde Kang

Objective: To review the role of dendritic cells (DC) in immune metabolism of rheumatoid arthritis (RA).

Methods: Literature on the role of DC in the immune metabolism of RA was extensively reviewed in recent years, and the metabolic characteristics of RA, the role of DC in RA, the correlation between the immune metabolism of DC and pathogenesis of RA, and the treatment were summarized and analyzed.

Results: DC promotes the progression of RA under hypoxia, increased glycolysis, inhibition of oxidative phosphorylation, and decreased lipid metabolism. Moreover, many DCs (especially conventional DC and monocyte-derived DC) have different functions and phenotypic characteristics in RA, which are closely related to the occurrence and development of RA.

Conclusion: DC plays an important role in the immune metabolism of RA, and immunometabolism therapy based on DC can provide targeted therapy for the treatment of RA.

目的:探讨树突状细胞(DC)在类风湿关节炎(RA)免疫代谢中的作用。方法:广泛查阅近年来有关DC在RA免疫代谢中的作用的文献,总结分析RA的代谢特点、DC在RA中的作用、DC免疫代谢与RA发病机制的相关性及治疗方法。结果:DC促进缺氧条件下RA的进展,增加糖酵解,抑制氧化磷酸化,降低脂质代谢。而且,许多DC(尤其是常规DC和单核细胞源性DC)在RA中具有不同的功能和表型特征,与RA的发生发展密切相关。结论:DC在RA的免疫代谢中起重要作用,基于DC的免疫代谢治疗可为RA的治疗提供靶向治疗。
{"title":"[Research progress on the role of dendritic cells in immune metabolism of rheumatoid arthritis].","authors":"Guangtao Han, Shuo Sun, Qin Wang, Pengde Kang","doi":"10.7507/1002-1892.202408002","DOIUrl":"10.7507/1002-1892.202408002","url":null,"abstract":"<p><strong>Objective: </strong>To review the role of dendritic cells (DC) in immune metabolism of rheumatoid arthritis (RA).</p><p><strong>Methods: </strong>Literature on the role of DC in the immune metabolism of RA was extensively reviewed in recent years, and the metabolic characteristics of RA, the role of DC in RA, the correlation between the immune metabolism of DC and pathogenesis of RA, and the treatment were summarized and analyzed.</p><p><strong>Results: </strong>DC promotes the progression of RA under hypoxia, increased glycolysis, inhibition of oxidative phosphorylation, and decreased lipid metabolism. Moreover, many DCs (especially conventional DC and monocyte-derived DC) have different functions and phenotypic characteristics in RA, which are closely related to the occurrence and development of RA.</p><p><strong>Conclusion: </strong>DC plays an important role in the immune metabolism of RA, and immunometabolism therapy based on DC can provide targeted therapy for the treatment of RA.</p>","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"38 12","pages":"1537-1541"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A comparative study of mid- and long-term effectiveness of patellar resurfacing or non-resurfacing in primary total knee arthroplasty]. [一期全膝关节置换术中髌骨置换与非髌骨置换中长期疗效的比较研究]。
Q3 Medicine Pub Date : 2024-12-15 DOI: 10.7507/1002-1892.202408057
Te Liu, Ye Tao, Junlei Song, Chengqi Jia, Runkai Zhao, Jun Fu, Jiying Chen, Ming Ni
<p><strong>Objective: </strong>To compare the mid- and long-term effectiveness of patellar resurfacing versus non-resurfacing in primary total knee arthroplasty (TKA).</p><p><strong>Methods: </strong>Twenty-six patients who underwent bilateral TKA between March 2013 and September 2015 were selected as the study subjects. One side was randomly chosen for patellar resurfacing (resurfacing group), and the other side was not (control group). There were 4 males and 22 females, the age ranged from 51 to 65 years, with an average of 59 years. According to Kellgren-Lawrence classification, there were 21 cases of grade Ⅳ and 5 cases of grade Ⅲ in both knees. There was no significant difference in the surgical side, and preoperative clinical and functional scores of the Knee Society Score (KSS), visual analogue scale (VAS) score, and the composition ratio of anterior knee pain localization points between the two groups ( <i>P</i>>0.05). The operation time, intraoperative blood loss, postoperative abnormal signs such as patellar clunk, feeling of constraint, patellar tendon weakness, crepitus, or snow-on-glass sensation, and the occurrence of complications were recorded and compared. Patient subjective evaluations included Forgotten Joint Score (FJS) and the degree of difficulty in high-level knee activities (including flexion with load bearing, going upstairs, going downstairs, squatting and standing up, kneeling, knee extension, and crossing legs for 7 items); KSS clinical/functional scores and VAS scores were used to evaluate the recovery of knee joint function, and the location of anterior knee pain was determined by a localization diagram.</p><p><strong>Results: </strong>The operation time of the resurfacing group was significantly longer than that of the control group ( <i>P</i><0.05), and there was no significant difference in intraoperative blood loss between the two groups ( <i>P</i>>0.05). All patients' incisions healed by first intention; the hospital stay ranged from 8 to 23 days, with an average of 12.6 days. All patients were followed up 9-11 years, with an average of 9.7 years. Except for 1 case who died of multiple organ failure due to internal diseases at 9 years after operation and 5 cases with incomplete radiological data, the rest 20 patients were assessed radiologically and found that 1 side of the knee joint in the control group had patellar dislocation; the remaining patients had no prosthetic failure (fracture, loosening, displacement, <i>etc.</i>), patellar fracture, patellar necrosis, patellar instability, patellar tendon rupture, prosthetic revision, <i>etc.</i> No patients had reoperations due to patellar-related complications or anterior knee pain in both knee joints. At 2 years postoperatively and at last follow-up, there was no significant difference in the incidence of abnormal signs such as patellar clunk, feeling of constraint, patellar tendon weakness, crepitus, or snow-on-glass sensation, the incidence of high-level knee
目的:比较原发性全膝关节置换术中髌骨置换与非髌骨置换的中长期疗效。方法:选取2013年3月至2015年9月间行双侧TKA的患者26例作为研究对象。随机选择一侧进行髌骨置换(置换组),另一侧不进行髌骨置换(对照组)。男性4例,女性22例,年龄51 ~ 65岁,平均59岁。根据Kellgren-Lawrence分级,双膝Ⅳ级21例,Ⅲ级5例。两组手术侧、术前膝关节社会评分(KSS)、视觉模拟评分(VAS)、膝关节前侧疼痛定位点组成比的临床和功能评分比较,差异均无统计学意义(P < 0.05)。记录两组的手术时间、术中出血量、术后髌骨磕碰、拘束感、髌骨肌腱无力、皱襞、玻璃感等异常体征及并发症发生情况并进行比较。患者主观评价包括遗忘关节评分(FJS)和高水平膝关节活动的困难程度(包括负重屈曲、上楼、下楼、下蹲和站起、跪下、膝关节伸展和跷二腿共7项);采用KSS临床/功能评分和VAS评分评估膝关节功能恢复情况,通过定位图确定膝关节前侧疼痛的位置。结果:表面修复组手术时间明显长于对照组(p < 0.05)。所有患者切口均一次愈合;住院时间8 ~ 23天,平均12.6天。随访9 ~ 11年,平均9.7年。除1例术后9年因内部疾病导致多器官功能衰竭死亡,5例影像学资料不完整外,其余20例患者经影像学检查发现对照组1侧膝关节有髌骨脱位;其余患者无假体失效(骨折、松动、移位等)、髌骨骨折、髌骨坏死、髌骨不稳、髌骨肌腱断裂、假体翻修等。无患者因髌骨相关并发症或双膝关节前膝关节疼痛再手术。术后2年及最后一次随访时,两组患者髌骨磕响、拘束感、髌腱无力、肌颤、雪玻璃感等异常体征的发生率、膝关节高位活动困难发生率、膝关节前侧疼痛定位构成比比较,差异均无统计学意义(P < 0.05)。两组患者KSS临床评分、功能评分、VAS评分均较术前显著提高(p < 0.05)。术后2年及最后一次随访时,两组患者FJS评分比较,差异无统计学意义(P < 0.05)。结论:髌骨表面置换与不髌骨表面置换在原发性全膝关节置换术中的中长期疗效相似。
{"title":"[A comparative study of mid- and long-term effectiveness of patellar resurfacing or non-resurfacing in primary total knee arthroplasty].","authors":"Te Liu, Ye Tao, Junlei Song, Chengqi Jia, Runkai Zhao, Jun Fu, Jiying Chen, Ming Ni","doi":"10.7507/1002-1892.202408057","DOIUrl":"10.7507/1002-1892.202408057","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To compare the mid- and long-term effectiveness of patellar resurfacing versus non-resurfacing in primary total knee arthroplasty (TKA).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Twenty-six patients who underwent bilateral TKA between March 2013 and September 2015 were selected as the study subjects. One side was randomly chosen for patellar resurfacing (resurfacing group), and the other side was not (control group). There were 4 males and 22 females, the age ranged from 51 to 65 years, with an average of 59 years. According to Kellgren-Lawrence classification, there were 21 cases of grade Ⅳ and 5 cases of grade Ⅲ in both knees. There was no significant difference in the surgical side, and preoperative clinical and functional scores of the Knee Society Score (KSS), visual analogue scale (VAS) score, and the composition ratio of anterior knee pain localization points between the two groups ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). The operation time, intraoperative blood loss, postoperative abnormal signs such as patellar clunk, feeling of constraint, patellar tendon weakness, crepitus, or snow-on-glass sensation, and the occurrence of complications were recorded and compared. Patient subjective evaluations included Forgotten Joint Score (FJS) and the degree of difficulty in high-level knee activities (including flexion with load bearing, going upstairs, going downstairs, squatting and standing up, kneeling, knee extension, and crossing legs for 7 items); KSS clinical/functional scores and VAS scores were used to evaluate the recovery of knee joint function, and the location of anterior knee pain was determined by a localization diagram.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The operation time of the resurfacing group was significantly longer than that of the control group ( &lt;i&gt;P&lt;/i&gt;&lt;0.05), and there was no significant difference in intraoperative blood loss between the two groups ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). All patients' incisions healed by first intention; the hospital stay ranged from 8 to 23 days, with an average of 12.6 days. All patients were followed up 9-11 years, with an average of 9.7 years. Except for 1 case who died of multiple organ failure due to internal diseases at 9 years after operation and 5 cases with incomplete radiological data, the rest 20 patients were assessed radiologically and found that 1 side of the knee joint in the control group had patellar dislocation; the remaining patients had no prosthetic failure (fracture, loosening, displacement, &lt;i&gt;etc.&lt;/i&gt;), patellar fracture, patellar necrosis, patellar instability, patellar tendon rupture, prosthetic revision, &lt;i&gt;etc.&lt;/i&gt; No patients had reoperations due to patellar-related complications or anterior knee pain in both knee joints. At 2 years postoperatively and at last follow-up, there was no significant difference in the incidence of abnormal signs such as patellar clunk, feeling of constraint, patellar tendon weakness, crepitus, or snow-on-glass sensation, the incidence of high-level knee ","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"38 12","pages":"1451-1457"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
中国修复重建外科杂志
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1