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[Effectiveness of sacroiliac screw implantation assisted by three-dimensional printed faceted honeycomb guide plate in treatment of posterior pelvic ring fracture]. [三维打印面蜂窝导板辅助骶髂螺钉植入治疗骨盆后环骨折的疗效]。
Q3 Medicine Pub Date : 2024-11-15 DOI: 10.7507/1002-1892.202405078
Bin Sheng, Chao Liu, Yiwei Wang, Rui Xiao, Ying Lu, Delong Liu, Zhanyu Yang, Yusi Wang
<p><strong>Objective: </strong>To investigate the effectiveness of sacroiliac screw implantation assisted by three-dimensional (3D) printed faceted honeycomb guide plate in the treatment of posterior pelvic ring fracture.</p><p><strong>Methods: </strong>The clinical data of 40 patients with posterior pelvic ring fractures treated with sacroiliac screw implantation between December 2019 and December 2022 were retrospectively analyzed. Among them, 18 cases were treated with sacroiliac screws fixation assisted by 3D printed faceted honeycomb guide plate (guide plate group), and 22 cases were treated with sacroiliac screws percutaneously fixation under fluoroscopy (conventional group). There was no significant difference in baseline data ( <i>P</i>>0.05) such as gender, age, time from injury to operation, and Dennis classification between the two groups. The implantation time, frequency of C-arm X-ray fluoroscopy, frequency of guide pin adjustment of each sacroiliac screw, and postoperative complications and bone healing were recorded. Majeed score was used to evaluate the functional recovery at 6 months after operation, and CT was used to observe whether the screw penetrated the bone cortex. The deviation between the virtual position and the actual position of the screw tip, the sacral foramen, and the screw entry point was measured on the sagittal CT images of the guide plate group.</p><p><strong>Results: </strong>The number of screws implanted in S <sub>1</sub> and S <sub>2</sub> vertebral bodies was 14 and 16 respectively in the guide plate group, and 17 and 18 respectively in the conventional group. The implantation time of each sacroiliac screw, the frequency of C-arm X-ray fluoroscopy, and the frequency of guide pin adjustment in S <sub>1</sub>, S <sub>2</sub>, and all vertebrae in the guide plate group were significantly less than those in the conventional group ( <i>P</i><0.05). Patients in both groups were followed up 8-48 months, with an average of 19.7 months. There was no incision infection, screw displacement, or internal fixation loosening in both groups. Callus growth was observed in all patients at 12 weeks after operation, and bone healing was achieved in all patients. The healing time ranged from 12 to 24 weeks, with an average of 15.7 weeks. No sacroiliac screw penetrated the bone cortex in the guide plate group; 2 patients in the conventional group had sacroiliac screws penetrating the bone cortex without damaging blood vessels or nerves. In the guide plate group, the deviation between the virtual position and the actual position of the screw tip, the sacral foramen, and the screw entry point were (2.91±1.01), (2.10±0.74), and (1.67±0.70) mm, respectively, with an average deviation of (2.19±1.22) mm. There was no significant difference in Majeed function evaluation between the two groups at 6 months after operation ( <i>P</i>>0.05).</p><p><strong>Conclusion: </strong>The application of 3D printed faceted honeycomb guide plate in
目的研究三维(3D)打印面蜂窝导板辅助骶髂螺钉植入治疗骨盆后环形骨折的效果:回顾性分析2019年12月至2022年12月期间40例采用骶髂螺钉植入治疗的骨盆后环形骨折患者的临床资料。其中,18例采用3D打印面蜂窝导板辅助骶髂螺钉固定治疗(导板组),22例在透视下经皮骶髂螺钉固定治疗(常规组)。两组患者的性别、年龄、受伤至手术时间、丹尼斯分级等基线数据无明显差异(P>0.05)。记录了植入时间、C型臂X光透视次数、每枚骶髂螺钉的导针调整次数、术后并发症和骨愈合情况。术后6个月时使用Majeed评分评估功能恢复情况,并使用CT观察螺钉是否穿透骨皮质。在导板组的矢状CT图像上测量螺钉尖端、骶骨孔和螺钉进入点的虚拟位置与实际位置之间的偏差:导板组在S 1和S 2椎体中植入的螺钉数量分别为14和16枚,常规组分别为17和18枚。导板组每枚骶髂螺钉的植入时间、C型臂X光透视次数以及S 1、S 2和所有椎体的导针调整次数均显著少于常规组(PP>0.05):结论:在骨盆后环骨折的骶髂螺钉植入术中应用3D打印面蜂窝导板,可缩短螺钉植入时间,减少透视和导针调整次数,降低螺钉穿透骨皮质的风险。
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引用次数: 0
[Application and progress of bio-derived materials in bladder regeneration and repair]. [生物衍生材料在膀胱再生和修复中的应用及进展]。
Q3 Medicine Pub Date : 2024-11-15 DOI: 10.7507/1002-1892.202404099
Xiuzhen Zhang, Jiawei Wang, Huiqi Xie

Objective: To summarize the research progress of bio-derived materials used for bladder regeneration and repair.

Methods: The recent domestic and foreign sutudies on bio-derived materials used for bladder regeneration and repair, including classification, morphology optimization process, tissue regeneration strategies, and relevant clinical trials, were summarized and analyzed.

Results: Numerous types of bio-derived materials are employed in bladder regeneration and repair, characterized by their low immunogenicity and high inducible activity. Surface modification, gelation, and other morphology optimization process have significantly broadened the application scope of bio-derived materials. These advancements have effectively addressed complications, such as perforation and urolith formation, that may arise during bladder regeneration and repair. The strategy of tissue regeneration utilizing bio-derived materials, targeting the regeneration of bladder epithelium, smooth muscle, blood vessels, and nerves, offers a novel approach to achieving functional regeneration of bladder. Bio-derived materials show great promise for use in bladder regeneration and repair, yet the results from clinical trials with these materials have been less than satisfactory.

Conclusion: Bio-derived materials are widely used in bladder regeneration and repair due to the good biocompatibility, low immunogenicity, and degradable properties, yet face a series of problems, and there are no commercialized bladder tissue engineering grafts used in clinical treatment.

目的:总结用于膀胱再生和修复的生物衍生材料的研究进展:总结膀胱再生修复生物材料的研究进展:方法:总结和分析近年来国内外关于膀胱再生与修复生物材料的研究,包括分类、形态优化过程、组织再生策略以及相关临床试验:结果:许多类型的生物衍生材料被用于膀胱再生和修复,其特点是免疫原性低、诱导活性高。表面修饰、凝胶化和其他形态优化过程大大拓宽了生物衍生材料的应用范围。这些进步有效解决了膀胱再生和修复过程中可能出现的穿孔和尿石形成等并发症。利用生物衍生材料进行组织再生的策略,以膀胱上皮、平滑肌、血管和神经的再生为目标,为实现膀胱功能再生提供了一种新方法。生物衍生材料在膀胱再生和修复中的应用前景广阔,但这些材料的临床试验结果却不尽如人意:结论:生物衍生材料具有良好的生物相容性、低免疫原性和可降解性,因此被广泛应用于膀胱再生和修复,但也面临着一系列问题,目前还没有商业化的膀胱组织工程移植物用于临床治疗。
{"title":"[Application and progress of bio-derived materials in bladder regeneration and repair].","authors":"Xiuzhen Zhang, Jiawei Wang, Huiqi Xie","doi":"10.7507/1002-1892.202404099","DOIUrl":"10.7507/1002-1892.202404099","url":null,"abstract":"<p><strong>Objective: </strong>To summarize the research progress of bio-derived materials used for bladder regeneration and repair.</p><p><strong>Methods: </strong>The recent domestic and foreign sutudies on bio-derived materials used for bladder regeneration and repair, including classification, morphology optimization process, tissue regeneration strategies, and relevant clinical trials, were summarized and analyzed.</p><p><strong>Results: </strong>Numerous types of bio-derived materials are employed in bladder regeneration and repair, characterized by their low immunogenicity and high inducible activity. Surface modification, gelation, and other morphology optimization process have significantly broadened the application scope of bio-derived materials. These advancements have effectively addressed complications, such as perforation and urolith formation, that may arise during bladder regeneration and repair. The strategy of tissue regeneration utilizing bio-derived materials, targeting the regeneration of bladder epithelium, smooth muscle, blood vessels, and nerves, offers a novel approach to achieving functional regeneration of bladder. Bio-derived materials show great promise for use in bladder regeneration and repair, yet the results from clinical trials with these materials have been less than satisfactory.</p><p><strong>Conclusion: </strong>Bio-derived materials are widely used in bladder regeneration and repair due to the good biocompatibility, low immunogenicity, and degradable properties, yet face a series of problems, and there are no commercialized bladder tissue engineering grafts used in clinical treatment.</p>","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"38 11","pages":"1299-1306"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142627904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Role of R-spondin 2 on osteogenic differentiation of bone marrow mesenchymal stem cells and bone metabolism in ovariectomized mice]. [R-spondin 2 对卵巢切除小鼠骨髓间充质干细胞成骨分化和骨代谢的作用]。
Q3 Medicine Pub Date : 2024-11-15 DOI: 10.7507/1002-1892.202406083
Xin Liu, Bowen Shi, Chengkuo Cai, Haotian Wang, Peng Jia
<p><strong>Objective: </strong>To investigate the effects of R-spondin 2 (Rspo2) on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and bone mineral content in ovariectomized mice.</p><p><strong>Methods: </strong>BMSCs were extracted from the bone marrow of the long bones of 7 4-week-old female C57BL/6 mice using whole bone marrow culture and passaged. After the cell phenotype was identified by flow cytometry, the 3rd generation cells were co-cultured with 10, 20, 40, 80, and 100 nmol/L Rspo2. Then, the cell activity and proliferative capacity were determined by cell counting kit 8 (CCK-8), and the intervention concentration of Rspo2 was screened for the subsequent experiments. The osteogenic differentiation ability of BMSCs was detected by alkaline phosphatase (ALP) staining, and the mRNA levels of osteogenesis-related genes [RUNX family transcription factor 2 (Runx2), collagen type Ⅰ alpha 1 (Col1), osteocalcin (OCN)] were detected by real-time fluorescence quantitative PCR (RT-qPCR). In addition, 18 10-week-old female C57BL/6 mice were randomly divided into sham operation group (sham group), ovariectomy group (OVX group), and OVX+Rspo2-intervention group (OVX+Rspo2 group), with 6 mice in each group. The sham group only underwent bilateral back incision and suturing, while the other two groups established osteoporosis mouse models by bilateral ovarian castration. Then, the mice were given a weekly intraperitoneal Rspo2 (1 mg/kg) treatment in OVX+Rspo2 group and saline at the same dosage in sham group and OVX group. After 12 weeks of treatment, the body mass and uterus mass of the mice were weighed in the 3 groups to assess whether the OVX model was successfully prepared; the tibia bones were stained with HE and immunohistochemistry staining to observe the changes in tibial bone mass and the expression level of Runx2 protein in the bone tissues. Blood was collected to detect the expressions of bone metabolism markers [ALP, OCN, type Ⅰ procollagen amino-terminal peptide (PINP)] and bone resorption marker [β-collagen degradation product (β-CTX)] by ELISA assay. Micro-CT was used to detect the bone microstructure changes in the tibia, and three-dimensional histomorphometric analyses were performed to analyze the trabeculae thickness (Tb.Th), trabeculae number (Tb.N), trabeculae separation (Tb.Sp), and bone volume fraction (BV/TV).</p><p><strong>Results: </strong>CCK-8 assay showed that Rspo2 concentrations below 80 nmol/L were not cytotoxic ( <i>P</i>>0.05), and the cell viability of 20 nmol/L Rspo2 group was significantly higher than that of the control group ( <i>P</i><0.05). Based on the above results, 10, 20, and 40 nmol/L Rspo2 were selected for subsequent experiments. ALP staining showed that the positive cell area of each concentration of Rspo2 group was significantly larger than that of the control group ( <i>P</i><0.05), with the highest showed in the 20 nmol/L Rspo2 group. The expression levels of the osteogen
目的研究R-spondin 2(Rspo2)对卵巢切除小鼠骨髓间充质干细胞(BMSCs)成骨分化和骨矿物质含量的影响:用全骨髓培养法从7只4周龄雌性C57BL/6小鼠的长骨骨髓中提取骨髓间充质干细胞并进行传代。用流式细胞仪鉴定细胞表型后,将第 3 代细胞与 10、20、40、80 和 100 nmol/L Rspo2 共同培养。然后,用细胞计数试剂盒 8(CCK-8)测定细胞活性和增殖能力,并筛选出 Rspo2 的干预浓度,用于后续实验。碱性磷酸酶(ALP)染色检测 BMSCs 的成骨分化能力,实时荧光定量 PCR(RT-qPCR)检测成骨相关基因[RUNX 家族转录因子 2(Runx2)、Ⅰ型α1 胶原(Col1)、骨钙素(OCN)]的 mRNA 水平。此外,将 18 只 10 周龄雌性 C57BL/6 小鼠随机分为假手术组(假组)、卵巢切除组(卵巢切除组)和卵巢切除+Rspo2-干预组(卵巢切除+Rspo2 组),每组 6 只。假组仅进行双侧背部切开缝合,而其他两组则通过双侧卵巢阉割建立骨质疏松症小鼠模型。然后,OVX+Rspo2 组小鼠每周腹腔注射 Rspo2(1 毫克/千克),假组和 OVX 组小鼠每周腹腔注射相同剂量的生理盐水。治疗12周后,称量3组小鼠的体重和子宫质量,以评估OVX模型是否制备成功;对胫骨进行HE染色和免疫组化染色,以观察胫骨骨量的变化和骨组织中Runx2蛋白的表达水平。采血通过 ELISA 检测骨代谢标志物[ALP、OCN、Ⅰ型胶原氨基端肽(PINP)]和骨吸收标志物[β-胶原降解产物(β-CTX)]的表达。利用显微 CT 检测胫骨的骨微结构变化,并对骨小梁厚度(Tb.Th)、骨小梁数量(Tb.N)、骨小梁分离度(Tb.Sp)和骨体积分数(BV/TV)进行三维组织形态分析:CCK-8检测表明,Rspo2浓度低于80 nmol/L时无细胞毒性(P>0.05),20 nmol/L Rspo2组的细胞存活率显著高于对照组(PPPPPPPPC结论:Rspo2能促进骨分化:Rspo2能促进BMSCs向成骨细胞分化,改善雌激素缺乏导致的骨质疏松症,促进小鼠骨形成。
{"title":"[Role of R-spondin 2 on osteogenic differentiation of bone marrow mesenchymal stem cells and bone metabolism in ovariectomized mice].","authors":"Xin Liu, Bowen Shi, Chengkuo Cai, Haotian Wang, Peng Jia","doi":"10.7507/1002-1892.202406083","DOIUrl":"10.7507/1002-1892.202406083","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the effects of R-spondin 2 (Rspo2) on the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and bone mineral content in ovariectomized mice.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;BMSCs were extracted from the bone marrow of the long bones of 7 4-week-old female C57BL/6 mice using whole bone marrow culture and passaged. After the cell phenotype was identified by flow cytometry, the 3rd generation cells were co-cultured with 10, 20, 40, 80, and 100 nmol/L Rspo2. Then, the cell activity and proliferative capacity were determined by cell counting kit 8 (CCK-8), and the intervention concentration of Rspo2 was screened for the subsequent experiments. The osteogenic differentiation ability of BMSCs was detected by alkaline phosphatase (ALP) staining, and the mRNA levels of osteogenesis-related genes [RUNX family transcription factor 2 (Runx2), collagen type Ⅰ alpha 1 (Col1), osteocalcin (OCN)] were detected by real-time fluorescence quantitative PCR (RT-qPCR). In addition, 18 10-week-old female C57BL/6 mice were randomly divided into sham operation group (sham group), ovariectomy group (OVX group), and OVX+Rspo2-intervention group (OVX+Rspo2 group), with 6 mice in each group. The sham group only underwent bilateral back incision and suturing, while the other two groups established osteoporosis mouse models by bilateral ovarian castration. Then, the mice were given a weekly intraperitoneal Rspo2 (1 mg/kg) treatment in OVX+Rspo2 group and saline at the same dosage in sham group and OVX group. After 12 weeks of treatment, the body mass and uterus mass of the mice were weighed in the 3 groups to assess whether the OVX model was successfully prepared; the tibia bones were stained with HE and immunohistochemistry staining to observe the changes in tibial bone mass and the expression level of Runx2 protein in the bone tissues. Blood was collected to detect the expressions of bone metabolism markers [ALP, OCN, type Ⅰ procollagen amino-terminal peptide (PINP)] and bone resorption marker [β-collagen degradation product (β-CTX)] by ELISA assay. Micro-CT was used to detect the bone microstructure changes in the tibia, and three-dimensional histomorphometric analyses were performed to analyze the trabeculae thickness (Tb.Th), trabeculae number (Tb.N), trabeculae separation (Tb.Sp), and bone volume fraction (BV/TV).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;CCK-8 assay showed that Rspo2 concentrations below 80 nmol/L were not cytotoxic ( &lt;i&gt;P&lt;/i&gt;&gt;0.05), and the cell viability of 20 nmol/L Rspo2 group was significantly higher than that of the control group ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). Based on the above results, 10, 20, and 40 nmol/L Rspo2 were selected for subsequent experiments. ALP staining showed that the positive cell area of each concentration of Rspo2 group was significantly larger than that of the control group ( &lt;i&gt;P&lt;/i&gt;&lt;0.05), with the highest showed in the 20 nmol/L Rspo2 group. The expression levels of the osteogen","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"38 11","pages":"1399-1407"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Clinical diagnostic study of Ramp lesion of medial meniscus based on knee MRI at 90° flexed position]. [基于膝关节 90°屈曲位核磁共振成像的内侧半月板斜坡病变临床诊断研究]。
Q3 Medicine Pub Date : 2024-11-15 DOI: 10.7507/1002-1892.202406059
Yuan Yao, Shujun Liu, Xianxiang Xiang, Zhiheng Wei, Weiming Wang, Jue Gong

Objective: To evaluate the clinical diagnostic value of knee MRI at 90° flexed position for Ramp lesions of medial meniscus.

Methods: A total of 228 patients with knee pain as the main complaint who were admitted between September 2021 and September 2023 was selected as the research subjects, of which 51 patients met the selection criteria and were enrolled in the study. There were 31 males and 20 females with an average age of 38.6 years (range, 15-67 years). Body mass index was 17.2-28.7 kg/m 2 (mean, 23.9 kg/m 2). There were 25 cases of left knee and 36 cases of right knee. The time from injury to admission was 0.1-14.3 weeks (mean, 2.1 weeks). Preoperative knee MRI at fully extended position (knee extension position) and 90° flexed position (knee flexion position) were performed to determine the presence of irregular signs at the posterior edge of the medial meniscus, and PHMM fluid high signal [i.e. complete fluid filling between the posterior horn of the medial meniscus (PHMM) and the capsule margin]. Findings obtained under arthroscopy served as the "gold standard" to analyze the sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of MRI at knee extension and flexion positions for the two specific signs of Ramp lesion.

Results: Twenty-one patients (41.2%) were diagnosed with Ramp lesions by using arthroscopy, including 1 case of Thaunat type Ⅰ, 2 cases of type Ⅱ, 6 cases of type Ⅲ, 7 cases of type Ⅳ, and 5 cases of type Ⅴ. The positive rates of irregular signs at the posterior edge of the medial meniscus on MRI at knee extension and flexion positions were significantly different from the diagnosis of Ramp injury under arthroscopy ( P<0.05). The sensitivity, specificity, accuracy, PPV, and NPV of MRI in the diagnosis of irregular signs were 76.1%, 60.0%, 66.7%, 57.1%, and 78.3% respectively at knee extension position, and 85.7%, 73.3%, 78.4%, 69.2%, and 88.0% respectively at knee flexion position. The positive rates of PHMM fluid high signal on MRI at knee extension and flexion positions were significantly different from the diagnosis of Ramp injury under arthroscopy ( P<0.05). The sensitivity, specificity, accuracy, PPV, and NPV of MRI in diagnosing PHMM fluid high signal were 38.1%, 100%, 74.5%, 100%, and 69.8% respectively at knee extension position, and 85.7%, 100%, 94.1%, 100%, and 90.9% respectively at knee flexion position.

Conclusion: Knee MRI at 90° flexed position improves the diagnostic performance of the detection of medial meniscal Ramp lesions compared with MRI at fully extended position.

目的:评估膝关节 90°屈曲位核磁共振成像对内侧半月板损伤的临床诊断价值:评估膝关节90°屈曲位核磁共振成像对内侧半月板Ramp病变的临床诊断价值:选取 2021 年 9 月至 2023 年 9 月期间收治的以膝关节疼痛为主诉的 228 例患者作为研究对象,其中 51 例患者符合入选标准并纳入研究。其中男性 31 人,女性 20 人,平均年龄 38.6 岁(15-67 岁)。体重指数为 17.2-28.7 kg/m2(平均为 23.9 kg/m2)。其中左膝 25 例,右膝 36 例。从受伤到入院的时间为0.1-14.3周(平均2.1周)。术前分别在完全伸直位(膝关节伸直位)和屈曲90°位(膝关节屈曲位)进行膝关节核磁共振成像检查,以确定内侧半月板后缘是否存在不规则征象,以及PHMM液体高信号[即内侧半月板后角(PHMM)和关节囊边缘之间完全充满液体]。以关节镜检查结果为 "金标准",分析膝关节伸直位和屈曲位核磁共振成像对 Ramp 病变两种特殊征象的敏感性、特异性、准确性、阳性预测值(PPV)和阴性预测值(NPV):21例(41.2%)患者通过关节镜检查确诊为Ramp病变,其中Thaunat Ⅰ型1例,Ⅱ型2例,Ⅲ型6例,Ⅳ型7例,Ⅴ型5例。膝关节伸直位和屈曲位核磁共振成像显示内侧半月板后缘不规则征象的阳性率与关节镜下的 Ramp 损伤诊断有显著差异(PPConclusion):与完全伸直位的核磁共振成像相比,90°屈曲位的膝关节核磁共振成像可提高内侧半月板Ramp损伤的诊断率。
{"title":"[Clinical diagnostic study of Ramp lesion of medial meniscus based on knee MRI at 90° flexed position].","authors":"Yuan Yao, Shujun Liu, Xianxiang Xiang, Zhiheng Wei, Weiming Wang, Jue Gong","doi":"10.7507/1002-1892.202406059","DOIUrl":"10.7507/1002-1892.202406059","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical diagnostic value of knee MRI at 90° flexed position for Ramp lesions of medial meniscus.</p><p><strong>Methods: </strong>A total of 228 patients with knee pain as the main complaint who were admitted between September 2021 and September 2023 was selected as the research subjects, of which 51 patients met the selection criteria and were enrolled in the study. There were 31 males and 20 females with an average age of 38.6 years (range, 15-67 years). Body mass index was 17.2-28.7 kg/m <sup>2</sup> (mean, 23.9 kg/m <sup>2</sup>). There were 25 cases of left knee and 36 cases of right knee. The time from injury to admission was 0.1-14.3 weeks (mean, 2.1 weeks). Preoperative knee MRI at fully extended position (knee extension position) and 90° flexed position (knee flexion position) were performed to determine the presence of irregular signs at the posterior edge of the medial meniscus, and PHMM fluid high signal [i.e. complete fluid filling between the posterior horn of the medial meniscus (PHMM) and the capsule margin]. Findings obtained under arthroscopy served as the \"gold standard\" to analyze the sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of MRI at knee extension and flexion positions for the two specific signs of Ramp lesion.</p><p><strong>Results: </strong>Twenty-one patients (41.2%) were diagnosed with Ramp lesions by using arthroscopy, including 1 case of Thaunat type Ⅰ, 2 cases of type Ⅱ, 6 cases of type Ⅲ, 7 cases of type Ⅳ, and 5 cases of type Ⅴ. The positive rates of irregular signs at the posterior edge of the medial meniscus on MRI at knee extension and flexion positions were significantly different from the diagnosis of Ramp injury under arthroscopy ( <i>P</i><0.05). The sensitivity, specificity, accuracy, PPV, and NPV of MRI in the diagnosis of irregular signs were 76.1%, 60.0%, 66.7%, 57.1%, and 78.3% respectively at knee extension position, and 85.7%, 73.3%, 78.4%, 69.2%, and 88.0% respectively at knee flexion position. The positive rates of PHMM fluid high signal on MRI at knee extension and flexion positions were significantly different from the diagnosis of Ramp injury under arthroscopy ( <i>P</i><0.05). The sensitivity, specificity, accuracy, PPV, and NPV of MRI in diagnosing PHMM fluid high signal were 38.1%, 100%, 74.5%, 100%, and 69.8% respectively at knee extension position, and 85.7%, 100%, 94.1%, 100%, and 90.9% respectively at knee flexion position.</p><p><strong>Conclusion: </strong>Knee MRI at 90° flexed position improves the diagnostic performance of the detection of medial meniscal Ramp lesions compared with MRI at fully extended position.</p>","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"38 11","pages":"1346-1351"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Risk factors of perioperative deep venous thrombosis of lower extremities in elderly patients with femoral neck fracture]. [股骨颈骨折老年患者围手术期下肢深静脉血栓形成的风险因素]。
Q3 Medicine Pub Date : 2024-11-15 DOI: 10.7507/1002-1892.202403072
Yonggang Wang, Kai Fu, Wei Zheng, Qianying Cai, Shengbao Chen, Changqing Zhang, Xianyou Zheng

Objective: To investigate the incidence of perioperative deep venous thrombosis (DVT) of lower extremities and its risk factors in elderly patients with femoral neck fracture.

Methods: The clinical data of 4 109 elderly patients with femoral neck fracture admitted between August 2012 and November 2020 and met the selection criteria were retrospectively analyzed. Among them, there were 1 137 males and 2 972 females; their ages ranged from 65 to 101 years, with an average of 77.0 years. The time from fracture to admission ranged from 1 to 360 hours, with an average of 35.2 hours. There were 1 858 cases of hemiarthroplasty, 1 617 cases of total hip arthroplasty, and 634 cases of internal fixation surgery. The preoperative age-adjusted Charlson comorbidity index (aCCI) was 4 (3, 5). Perioperative DVT occurred in 857 cases (20.9%). Univariate analysis was performed on age, gender, body mass index, fracture side, time from fracture to admission, operation type, anesthesia type, blood transfusion, blood pressure after admission, and preoperative aCCI in patients with and without perioperative DVT, and logistic regression analysis was used to screen the risk factors of perioperative DVT in elderly patients with femoral neck fracture.

Results: Univariate analysis showed that there were significant differences in age, gender, time from fracture to admission, operation type, and preoperative aCCI between the two groups ( P<0.05). Further logistic regression analysis showed that age>75 years, female patients, time from fracture to admission>24 hours, and preoperative aCCI>5 were risk factors for perioperative DVT ( P<0.05).

Conclusion: Elderly patients with femoral neck fracture have a higher incidence of perioperative DVT. The advanced aged and female patients, patients with longer fracture time and more comorbidities need to pay special attention to the prevention of perioperative DVT to minimize the occurrence of DVT during femoral neck fractures.

目的研究老年股骨颈骨折患者围手术期下肢深静脉血栓(DVT)的发生率及其风险因素:回顾性分析 2012 年 8 月至 2020 年 11 月期间收治的 4 109 例符合入选标准的老年股骨颈骨折患者的临床资料。其中,男性 1 137 例,女性 2 972 例;年龄在 65 岁至 101 岁之间,平均年龄为 77.0 岁。从骨折到入院的时间从 1 到 360 小时不等,平均为 35.2 小时。半髋关节置换术有1 858例,全髋关节置换术有1 617例,内固定手术有634例。术前年龄调整后的Charlson合并症指数(aCCI)为4(3,5)。围手术期发生深静脉血栓的病例有 857 例(20.9%)。对有和无围手术期深静脉血栓患者的年龄、性别、体重指数、骨折侧、骨折至入院时间、手术类型、麻醉类型、输血、入院后血压和术前 aCCI 进行单变量分析,并采用逻辑回归分析筛选老年股骨颈骨折患者围手术期深静脉血栓的风险因素:单变量分析显示,两组患者在年龄、性别、骨折至入院时间、手术类型、术前 aCCI(P75 岁、女性患者、骨折至入院时间>24 小时、术前 aCCI>5)等方面存在显著差异,均为股骨颈骨折围手术期深静脉血栓形成的危险因素:老年股骨颈骨折患者围术期深静脉血栓的发生率较高。高龄、女性、骨折时间较长、合并症较多的患者需要特别注意围手术期深静脉血栓的预防,以减少股骨颈骨折期间深静脉血栓的发生。
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引用次数: 0
[Early effectiveness of unilateral biportal endoscopy technique for migrated lumbar intervertebral disc herniation]. [单侧双ortal 内窥镜技术治疗移位腰椎间盘突出症的早期疗效]。
Q3 Medicine Pub Date : 2024-11-15 DOI: 10.7507/1002-1892.202408026
Jijun Huang, Yongxiang Wang, Jiandong Yang, Xinmin Feng
<p><strong>Objective: </strong>To explore early effectiveness of unilateral biportal endoscopy (UBE) technique in the treatment of migrated lumbar intervertebral disc herniation.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 87 patients with migrated lumbar intervertebral disc herniation, who were treated with UBE technique between May 2021 and December 2022 and met the selection criteria. There were 55 males and 32 females, with an average age of 48.8 years (range, 29-74 years). The disease duration ranged from 2 to 23 months, with an average of 9.1 months. The surgical segments included 17 cases of L <sub>3, 4</sub>, 32 cases of L <sub>4, 5</sub>, and 38 cases of L <sub>5</sub>, S <sub>1</sub>. According to Lee's classification criteria, there were 12 cases of type 1, 17 cases of type 2, 37 cases of type 3, and 21 cases of type 4. The operation time, length of hospital stay, and complications were recorded. The visual analogue scale (VAS) score was used to assess the degree of low back and leg pain before operaion and at 3 days, 3 months, 6 months, and 12 months after operation. The Oswestry disability index (ODI) was used to evaluate the lumbar spine function. At last follow-up, the modified MacNab criteria was used to evaluate the effectiveness. According to the preoperative migrated intervertebral disc classification, the patients were allocated into groups Ⅰ to Ⅳ. The differences in VAS score and ODI were compared.</p><p><strong>Results: </strong>All 87 patients successfully completed the operations. There was no nerve root injury, dural sac injury, or dural tear during operation. The operation time was (58.6±14.6) minutes and the length of hospital stay was (4.0±0.8) days. All incisions healed by first intention after operation. No symptomatic epidural hematoma occurred. All patients were followed up for 12 months. There were significant differences in VAS scores and ODI at each time point after operation when compared with those before operation ( <i>P</i><0.05). There were significant differences in VAS score at 3 days after operation when compared with that at 3, 6, and 12 months after operation ( <i>P</i><0.05). For ODI, except that there was no significant difference between 6 and 12 months after operation ( <i>P</i>>0.05), there were significant differences between other time points after operation ( <i>P</i><0.05). At last follow-up, the effectiveness was rated as excellent in 66 cases, good in 13 cases, and fair in 8 cases according to the modified MacNab criteria, and the excellent and good rate was 90.8%. There was no intervertebral disc herniation recurred during follow-up period. There was no significant difference in VAS score and ODI among groups Ⅰ -Ⅳ before operation and at each time point after operation ( <i>P</i>>0.05).</p><p><strong>Conclusion: </strong>The UBE technique is safe and effective in the treatment of migrated lumbar intervertebral disc herniation, with a low complication rate and s
目的探讨单侧双侧内窥镜(UBE)技术治疗腰椎间盘突出症移位的早期疗效:方法:对 2021 年 5 月至 2022 年 12 月期间接受 UBE 技术治疗的 87 例符合入选标准的腰椎间盘突出症移位患者进行回顾性分析。其中男性 55 人,女性 32 人,平均年龄 48.8 岁(29-74 岁)。病程从 2 个月到 23 个月不等,平均为 9.1 个月。根据李氏分型标准,1 型 12 例,2 型 17 例,3 型 37 例,4 型 21 例。记录了手术时间、住院时间和并发症。采用视觉模拟量表(VAS)评分评估术前、术后 3 天、3 个月、6 个月和 12 个月的腰腿痛程度。Oswestry残疾指数(ODI)用于评估腰椎功能。最后一次随访时,采用改良的 MacNab 标准评估疗效。根据术前椎间盘移位分类,将患者分为Ⅰ至Ⅳ组。比较 VAS 评分和 ODI 的差异:结果:87 名患者均顺利完成手术。结果:87 例患者均顺利完成手术,术中无神经根损伤、硬膜囊损伤或硬膜撕裂。手术时间为(58.6±14.6)分钟,住院时间为(4.0±0.8)天。术后所有切口均以第一意向愈合。无症状性硬膜外血肿发生。所有患者均接受了 12 个月的随访。术后各时间点的VAS评分和ODI与术前相比差异有学意义(PPP>0.05),术后其他时间点之间差异有学意义(PP>0.05):结论:UBE技术治疗移位的腰椎间盘突出症安全有效,并发症发生率低,早期疗效令人满意。
{"title":"[Early effectiveness of unilateral biportal endoscopy technique for migrated lumbar intervertebral disc herniation].","authors":"Jijun Huang, Yongxiang Wang, Jiandong Yang, Xinmin Feng","doi":"10.7507/1002-1892.202408026","DOIUrl":"10.7507/1002-1892.202408026","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To explore early effectiveness of unilateral biportal endoscopy (UBE) technique in the treatment of migrated lumbar intervertebral disc herniation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A retrospective analysis was conducted on 87 patients with migrated lumbar intervertebral disc herniation, who were treated with UBE technique between May 2021 and December 2022 and met the selection criteria. There were 55 males and 32 females, with an average age of 48.8 years (range, 29-74 years). The disease duration ranged from 2 to 23 months, with an average of 9.1 months. The surgical segments included 17 cases of L &lt;sub&gt;3, 4&lt;/sub&gt;, 32 cases of L &lt;sub&gt;4, 5&lt;/sub&gt;, and 38 cases of L &lt;sub&gt;5&lt;/sub&gt;, S &lt;sub&gt;1&lt;/sub&gt;. According to Lee's classification criteria, there were 12 cases of type 1, 17 cases of type 2, 37 cases of type 3, and 21 cases of type 4. The operation time, length of hospital stay, and complications were recorded. The visual analogue scale (VAS) score was used to assess the degree of low back and leg pain before operaion and at 3 days, 3 months, 6 months, and 12 months after operation. The Oswestry disability index (ODI) was used to evaluate the lumbar spine function. At last follow-up, the modified MacNab criteria was used to evaluate the effectiveness. According to the preoperative migrated intervertebral disc classification, the patients were allocated into groups Ⅰ to Ⅳ. The differences in VAS score and ODI were compared.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;All 87 patients successfully completed the operations. There was no nerve root injury, dural sac injury, or dural tear during operation. The operation time was (58.6±14.6) minutes and the length of hospital stay was (4.0±0.8) days. All incisions healed by first intention after operation. No symptomatic epidural hematoma occurred. All patients were followed up for 12 months. There were significant differences in VAS scores and ODI at each time point after operation when compared with those before operation ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). There were significant differences in VAS score at 3 days after operation when compared with that at 3, 6, and 12 months after operation ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). For ODI, except that there was no significant difference between 6 and 12 months after operation ( &lt;i&gt;P&lt;/i&gt;&gt;0.05), there were significant differences between other time points after operation ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). At last follow-up, the effectiveness was rated as excellent in 66 cases, good in 13 cases, and fair in 8 cases according to the modified MacNab criteria, and the excellent and good rate was 90.8%. There was no intervertebral disc herniation recurred during follow-up period. There was no significant difference in VAS score and ODI among groups Ⅰ -Ⅳ before operation and at each time point after operation ( &lt;i&gt;P&lt;/i&gt;&gt;0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The UBE technique is safe and effective in the treatment of migrated lumbar intervertebral disc herniation, with a low complication rate and s","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"38 11","pages":"1367-1371"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Research progress of three-dimensional printed customized prosthesis and its application in acetabular reconstruction of hip revision surgery]. [三维打印定制假体的研究进展及其在髋关节翻修手术髋臼重建中的应用]。
Q3 Medicine Pub Date : 2024-11-15 DOI: 10.7507/1002-1892.202406002
Heng Zhang, Xiaodong Ma, Bowen Li, Kuanxin Li, Yang Liu, Jiansheng Zhou, Jun Tao

Objective: To review research progress on the design, manufacturing, and clinical application of three-dimensional (3D) printed customized prosthesis in acetabular reconstruction of hip revision surgery.

Methods: The related research literature on 3D printed customized prosthesis and its application in acetabular reconstruction of hip revision surgery was searched by key words of "3D printed customized prosthesis", "revision hip arthroplasty", "acetabular bone defect", and "acetabular reconstruction" between January 2013 and May 2024 in Chinese and English databases, such as CNKI, Wanfang database, PubMed, etc. A total of 34 271 articles were included. After reading the literature titles, abstracts, or full texts, the literature of unrelated, repetitive, low-quality, and low evidence level was screened out, and a total of 48 articles were finally included for analysis and summary.

Results: The bone growth and mechanical properties of 3D printed customized prosthesis materials are better than those of non-3D printed customized prosthesis, which further solves the problem of elastic modulus mismatch between the implant and natural bone caused by "stress shielding"; the porous structure and antibacterial coating on the surface of 3D printed customized prosthesis have good anti-bacterial effect. 3D printed customized prosthesis can perfectly match the patient's individual acetabular anatomical characteristics and defect type, thus improving the accuracy of acetabular reconstruction and reducing the surgical time and trauma.

Conclusion: 3D printed customized prosthesis can be used for precise and efficient individualized acetabular reconstruction in hip revision surgery with good early- and mid-term effectiveness. More optimized production technics and procedures need to be developed to improve the efficiency of clinical application and long-term effectiveness.

目的综述三维(3D)打印定制假体在髋关节翻修手术髋臼重建中的设计、制造和临床应用的研究进展:方法:以 "3D打印定制假体"、"翻修髋关节置换术"、"髋臼骨缺损"、"髋臼重建 "为关键词,检索2013年1月至2024年5月期间CNKI、万方数据库、PubMed等中英文数据库中关于3D打印定制假体及其在髋关节翻修手术髋臼重建中应用的相关研究文献。共纳入 34 271 篇文章。在阅读文献标题、摘要或全文后,筛选出无关、重复、低质量、低证据水平的文献,最终共纳入48篇文章进行分析和总结:3D打印定制假体材料的骨生长和力学性能优于非3D打印定制假体,进一步解决了 "应力屏蔽 "导致的假体与天然骨弹性模量不匹配的问题;3D打印定制假体的多孔结构和表面抗菌涂层具有良好的抗菌效果。结论:3D 打印定制假体可用于髋关节翻修手术中精确、高效的个体化髋臼重建,具有良好的早期和中期疗效。为了提高临床应用的效率和长期有效性,还需要开发更多优化的生产技术和程序。
{"title":"[Research progress of three-dimensional printed customized prosthesis and its application in acetabular reconstruction of hip revision surgery].","authors":"Heng Zhang, Xiaodong Ma, Bowen Li, Kuanxin Li, Yang Liu, Jiansheng Zhou, Jun Tao","doi":"10.7507/1002-1892.202406002","DOIUrl":"10.7507/1002-1892.202406002","url":null,"abstract":"<p><strong>Objective: </strong>To review research progress on the design, manufacturing, and clinical application of three-dimensional (3D) printed customized prosthesis in acetabular reconstruction of hip revision surgery.</p><p><strong>Methods: </strong>The related research literature on 3D printed customized prosthesis and its application in acetabular reconstruction of hip revision surgery was searched by key words of \"3D printed customized prosthesis\", \"revision hip arthroplasty\", \"acetabular bone defect\", and \"acetabular reconstruction\" between January 2013 and May 2024 in Chinese and English databases, such as CNKI, Wanfang database, PubMed, <i>etc</i>. A total of 34 271 articles were included. After reading the literature titles, abstracts, or full texts, the literature of unrelated, repetitive, low-quality, and low evidence level was screened out, and a total of 48 articles were finally included for analysis and summary.</p><p><strong>Results: </strong>The bone growth and mechanical properties of 3D printed customized prosthesis materials are better than those of non-3D printed customized prosthesis, which further solves the problem of elastic modulus mismatch between the implant and natural bone caused by \"stress shielding\"; the porous structure and antibacterial coating on the surface of 3D printed customized prosthesis have good anti-bacterial effect. 3D printed customized prosthesis can perfectly match the patient's individual acetabular anatomical characteristics and defect type, thus improving the accuracy of acetabular reconstruction and reducing the surgical time and trauma.</p><p><strong>Conclusion: </strong>3D printed customized prosthesis can be used for precise and efficient individualized acetabular reconstruction in hip revision surgery with good early- and mid-term effectiveness. More optimized production technics and procedures need to be developed to improve the efficiency of clinical application and long-term effectiveness.</p>","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"38 11","pages":"1414-1420"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142628985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Study on anti-adhesion effect and mechanism of dynamic and static stress stimulation during early healing process of rat Achilles tendon injury]. [大鼠跟腱损伤早期愈合过程中动态和静态应力刺激的抗粘连作用及机制研究]。
Q3 Medicine Pub Date : 2024-11-15 DOI: 10.7507/1002-1892.202405090
Jiani Wu, Yingzi Jiang, Guanyu Wang, Liliao Wang, Jie Bao, Jun Wang

Objective: To investigate the anti-adhesive effect and underlying mechanism of dynamic and static stress stimulation on the early healing process of rat Achilles tendon injury.

Methods: Achilles tendon tissues of 15 male Sprague Dawley (SD) rats aged 4-6 weeks were isolated and cultured by enzyme digestion method. Rat Achilles tendon cells were treated with tumor necrosis factor α to construct the Achilles tendon injury cell model, and dynamic stress stimulation (dynamic group) and static stress stimulation (static group) were applied respectively, while the control group was not treated. Live/dead cell double staining was used to detect cell activity, ELISA assay was used to detect the expression of α smooth muscle actin (α-SMA), and real-time fluorescence quantitative PCR was used to detect the mRNA expression of collagen type Ⅰ (COL1A1), collagen type Ⅲ (COL3A1), and Scleraxis (SCX). Thirty male SD rats aged 4-6 weeks underwent Achilles tendon suture and were randomly divided into dynamic group (treated by dynamic stress stimulation), static group (treated by static stress stimulation), and control group (untreated), with 10 rats in each group. HE staining and scoring were performed to evaluate the healing of Achilles tendon at 8 days after operation. COL1A1 and COL3A1 protein expressions were detected by immunohistochemical staining, α-SMA and SCX protein expressions were detected by Western blot, and maximum tendon breaking force and tendon stiffness were detected by biomechanical stretching test.

Results: In vitro cell experiment, when compared to the static group, the number of living cells in the dynamic group was higher, the expression of α-SMA protein was decreased, the relative expression of COL3A1 mRNA was decreased, and the relative expression of SCX mRNA was increased, and the differences were all significant ( P<0.05). In the in vivo animal experiment, when compared to the static group, the tendon healing in the dynamic group was better, the HE staining score was lower, the expression of COL1A1 protein was increased, the expression of COL3A1 protein was decreased, the relative expression of SCX protein was increased, the relative expression of α-SMA protein was decreased, and the tendon stiffness was increased, the differences were all significant ( P<0.05).

Conclusion: Compared with static stress stimulation, the dynamic stress stimulation improves the fibrosis of the scar tissue of the rat Achilles tendon, promote the recovery of the biomechanical property of the Achilles tendon, and has obvious anti-adhesion effect.

目的研究动态和静态应力刺激对大鼠跟腱损伤早期愈合过程的抗粘连作用及其内在机制:方法:分离 15 只 4-6 周龄雄性 Sprague Dawley(SD)大鼠的跟腱组织,用酶消化法进行培养。用肿瘤坏死因子α处理大鼠跟腱细胞,构建跟腱损伤细胞模型,分别给予动态应激刺激(动态组)和静态应激刺激(静态组),对照组不处理。活/死细胞双染色检测细胞活性,ELISA检测α平滑肌肌动蛋白(α-SMA)的表达,实时荧光定量PCR检测Ⅰ型胶原(COL1A1)、Ⅲ型胶原(COL3A1)和硬骨(SCX)的mRNA表达。30 只 4-6 周龄的雄性 SD 大鼠接受跟腱缝合术,随机分为动态组(动态应力刺激处理)、静态组(静态应力刺激处理)和对照组(未处理),每组 10 只。术后 8 天对跟腱愈合情况进行 HE 染色和评分。免疫组化染色法检测 COL1A1 和 COL3A1 蛋白表达,Western 印迹法检测 α-SMA 和 SCX 蛋白表达,生物力学拉伸试验检测最大肌腱断裂力和肌腱硬度:体外细胞实验,与静态组相比,动态组活细胞数增加,α-SMA 蛋白表达量减少,COL3A1 mRNA 相对表达量减少,SCX mRNA 相对表达量增加,差异均有显著性、动态组肌腱愈合较好,HE染色评分较低,COL1A1蛋白表达量增加,COL3A1蛋白表达量减少,SCX蛋白相对表达量增加,α-SMA蛋白相对表达量减少,肌腱硬度增加,差异均有显著性(PC结论:与静态应力刺激相比,动态应力刺激能改善大鼠跟腱瘢痕组织的纤维化,促进跟腱生物力学特性的恢复,并具有明显的抗粘连作用。
{"title":"[Study on anti-adhesion effect and mechanism of dynamic and static stress stimulation during early healing process of rat Achilles tendon injury].","authors":"Jiani Wu, Yingzi Jiang, Guanyu Wang, Liliao Wang, Jie Bao, Jun Wang","doi":"10.7507/1002-1892.202405090","DOIUrl":"10.7507/1002-1892.202405090","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the anti-adhesive effect and underlying mechanism of dynamic and static stress stimulation on the early healing process of rat Achilles tendon injury.</p><p><strong>Methods: </strong>Achilles tendon tissues of 15 male Sprague Dawley (SD) rats aged 4-6 weeks were isolated and cultured by enzyme digestion method. Rat Achilles tendon cells were treated with tumor necrosis factor α to construct the Achilles tendon injury cell model, and dynamic stress stimulation (dynamic group) and static stress stimulation (static group) were applied respectively, while the control group was not treated. Live/dead cell double staining was used to detect cell activity, ELISA assay was used to detect the expression of α smooth muscle actin (α-SMA), and real-time fluorescence quantitative PCR was used to detect the mRNA expression of collagen type Ⅰ (COL1A1), collagen type Ⅲ (COL3A1), and Scleraxis (SCX). Thirty male SD rats aged 4-6 weeks underwent Achilles tendon suture and were randomly divided into dynamic group (treated by dynamic stress stimulation), static group (treated by static stress stimulation), and control group (untreated), with 10 rats in each group. HE staining and scoring were performed to evaluate the healing of Achilles tendon at 8 days after operation. COL1A1 and COL3A1 protein expressions were detected by immunohistochemical staining, α-SMA and SCX protein expressions were detected by Western blot, and maximum tendon breaking force and tendon stiffness were detected by biomechanical stretching test.</p><p><strong>Results: </strong><i>In vitro</i> cell experiment, when compared to the static group, the number of living cells in the dynamic group was higher, the expression of α-SMA protein was decreased, the relative expression of COL3A1 mRNA was decreased, and the relative expression of SCX mRNA was increased, and the differences were all significant ( <i>P</i><0.05). In the <i>in vivo</i> animal experiment, when compared to the static group, the tendon healing in the dynamic group was better, the HE staining score was lower, the expression of COL1A1 protein was increased, the expression of COL3A1 protein was decreased, the relative expression of SCX protein was increased, the relative expression of α-SMA protein was decreased, and the tendon stiffness was increased, the differences were all significant ( <i>P</i><0.05).</p><p><strong>Conclusion: </strong>Compared with static stress stimulation, the dynamic stress stimulation improves the fibrosis of the scar tissue of the rat Achilles tendon, promote the recovery of the biomechanical property of the Achilles tendon, and has obvious anti-adhesion effect.</p>","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"38 11","pages":"1391-1398"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11563745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142629123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Progress and prospects in diagnosis and treatment of neurofibromatosis type 1]. [神经纤维瘤病 1 型诊断和治疗的进展与前景]。
Q3 Medicine Pub Date : 2024-10-15 DOI: 10.7507/1002-1892.202407005
Pi'nan Liu

Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disease caused by mutations in the NF1 gene. The disease is characterized by neurofibromatosis, which simultaneously affects multiple systems such as nerves, skin, and bone, and has complex clinical manifestations. Since the National Institutes of Health (NIH) established diagnostic criteria in 1988, the diagnosis and treatment of NF1 have progressed significantly. However, due to the complexity of the disease and the lack of effective treatments, the diagnosis and treatment of NF1 still face many challenges. Strengthening multidisciplinary collaboration, improving and popularizing disease diagnosis and treatment strategies, and developing more effective drugs and treatment methods are the keys to further improve the treatment level of NF1 diseases.

1 型神经纤维瘤病(NF1)是一种常染色体显性遗传病,由 NF1 基因突变引起。该病以神经纤维瘤病为特征,同时影响神经、皮肤和骨骼等多个系统,临床表现复杂。自 1988 年美国国立卫生研究院(NIH)制定诊断标准以来,NF1 的诊断和治疗取得了显著进展。然而,由于疾病的复杂性和缺乏有效的治疗方法,NF1 的诊断和治疗仍面临诸多挑战。加强多学科协作,完善和普及疾病诊治策略,开发更有效的药物和治疗方法,是进一步提高NF1疾病诊治水平的关键。
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引用次数: 0
[Perioperative changes of serum interleukin 6 levels in elderly male patients with intertrochanteric fracture]. [转子间骨折老年男性患者血清白细胞介素 6 水平的围手术期变化]。
Q3 Medicine Pub Date : 2024-10-15 DOI: 10.7507/1002-1892.202405057
Xiangxu Chen, Huanyi Zhu, Wei Wu, Chuwei Tian, Liu Shi, Wenbin Fan, Cheng Zhang, Yingjuan Li, Hui Chen, Wei Gao, Yunfeng Rui
<p><strong>Objective: </strong>To investigate the perioperative changes in serum interleukin 6 (IL-6) levels in elderly male patients with intertrochanteric fractures, and provide evidence for inflammatory control in this patient population.</p><p><strong>Methods: </strong>The clinical data of 40 male patients aged more than 60 years with intertrochanteric fractures who met the selection criteria between January 2021 and December 2022 were retrospectively analyzed, including 25 non-osteoporosis patients (T value>-2.5, group A) and 15 osteoporosis patients (T value≤-2.5, group B). In addition, 40 healthy men aged more than 60 years old were included as controls (group C) according to the age matching rule. There was no significant difference in age, smoking history, drinking history, body mass index, complications (hypertension and diabetes), alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine, and total protein among the 3 groups ( <i>P</i>>0.05). Serum samples were collected from group C subjects and from groups A and B patients preoperatively and on postoperative days 1, 3, 5, and 7. IL-6 levels were measured using ELISA assay. Pearson correlation analysis was used to assess the relationship between IL-6 levels and T values at various time points in groups A and B. Postoperative complications during hospitalization and 1-year mortality rates were recorded for groups A and B.</p><p><strong>Results: </strong>Preoperative IL-6 levels were significantly higher in groups A and B than in group C ( <i>P</i><0.05), with group B being significantly higher than group A ( <i>P</i><0.05). In groups A and B, IL-6 levels increased significantly on postoperative day 1 compared to preoperative levels and then gradually decreased, approaching preoperative levels by postoperative day 7. IL-6 levels in group B were significantly higher than those in group A at all postoperative time points ( <i>P</i><0.05). Correlation analysis showed that IL-6 levels were negatively correlated with T values at all perioperative time points in all patients from groups A and B ( <i>P</i><0.05). Complications occurred in 4 patients (16.0%) in group A, including 2 cases of pulmonary infection, 1 case of urinary tract infection, and 1 case of heart failure, and in 3 patients (20.0%) in group B, including 2 cases of pulmonary infection and 1 case of gastrointestinal bleeding. There was no significant difference in the incidence of complications between the two groups ( <i>χ</i> <sup>2</sup>=0.104, <i>P</i>=0.747). There were 2 cases (8.0%) and 4 cases (26.7%) died within 1 year after operation in groups A and B, respectively, and there was no significant difference in 1-year mortality rates between the two groups ( <i>χ</i> <sup>2</sup>=2.562, <i>P</i>=0.109).</p><p><strong>Conclusion: </strong>Serum IL-6 levels significantly increase in the early postoperative period in elderly male patients with intertrochanteric fractures, especially in those with
目的研究老年男性转子间骨折患者围手术期血清白细胞介素6(IL-6)水平的变化,为该患者群体的炎症控制提供证据:回顾性分析2021年1月至2022年12月期间符合入选标准的40例60岁以上男性转子间骨折患者的临床资料,包括25例非骨质疏松症患者(T值>-2.5,A组)和15例骨质疏松症患者(T值≤-2.5,B组)。此外,根据年龄匹配规则,40 名 60 岁以上的健康男性被纳入对照组(C 组)。三组患者的年龄、吸烟史、饮酒史、体重指数、并发症(高血压和糖尿病)、丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、血尿素氮、肌酐和总蛋白均无明显差异(P>0.05)。术前、术后第 1、3、5 和 7 天采集 C 组受试者、A 组和 B 组患者的血清样本。采用 ELISA 法测定 IL-6 水平。采用皮尔逊相关分析评估了 A 组和 B 组不同时间点 IL-6 水平与 T 值之间的关系,并记录了 A 组和 B 组住院期间的术后并发症和 1 年死亡率:A组和B组术前IL-6水平明显高于C组(PPPPχ 2=0.104,P=0.747)。A组和B组分别有2例(8.0%)和4例(26.7%)患者术后1年内死亡,两组1年死亡率无明显差异(χ 2=2.562,P=0.109):结论:老年男性转子间骨折患者术后早期血清IL-6水平明显升高,尤其是骨质疏松症患者。在围手术期监测炎症状态并及时控制炎症反应,可减少并发症的发生,提高这类患者的术后存活率。
{"title":"[Perioperative changes of serum interleukin 6 levels in elderly male patients with intertrochanteric fracture].","authors":"Xiangxu Chen, Huanyi Zhu, Wei Wu, Chuwei Tian, Liu Shi, Wenbin Fan, Cheng Zhang, Yingjuan Li, Hui Chen, Wei Gao, Yunfeng Rui","doi":"10.7507/1002-1892.202405057","DOIUrl":"10.7507/1002-1892.202405057","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the perioperative changes in serum interleukin 6 (IL-6) levels in elderly male patients with intertrochanteric fractures, and provide evidence for inflammatory control in this patient population.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The clinical data of 40 male patients aged more than 60 years with intertrochanteric fractures who met the selection criteria between January 2021 and December 2022 were retrospectively analyzed, including 25 non-osteoporosis patients (T value&gt;-2.5, group A) and 15 osteoporosis patients (T value≤-2.5, group B). In addition, 40 healthy men aged more than 60 years old were included as controls (group C) according to the age matching rule. There was no significant difference in age, smoking history, drinking history, body mass index, complications (hypertension and diabetes), alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine, and total protein among the 3 groups ( &lt;i&gt;P&lt;/i&gt;&gt;0.05). Serum samples were collected from group C subjects and from groups A and B patients preoperatively and on postoperative days 1, 3, 5, and 7. IL-6 levels were measured using ELISA assay. Pearson correlation analysis was used to assess the relationship between IL-6 levels and T values at various time points in groups A and B. Postoperative complications during hospitalization and 1-year mortality rates were recorded for groups A and B.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Preoperative IL-6 levels were significantly higher in groups A and B than in group C ( &lt;i&gt;P&lt;/i&gt;&lt;0.05), with group B being significantly higher than group A ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). In groups A and B, IL-6 levels increased significantly on postoperative day 1 compared to preoperative levels and then gradually decreased, approaching preoperative levels by postoperative day 7. IL-6 levels in group B were significantly higher than those in group A at all postoperative time points ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). Correlation analysis showed that IL-6 levels were negatively correlated with T values at all perioperative time points in all patients from groups A and B ( &lt;i&gt;P&lt;/i&gt;&lt;0.05). Complications occurred in 4 patients (16.0%) in group A, including 2 cases of pulmonary infection, 1 case of urinary tract infection, and 1 case of heart failure, and in 3 patients (20.0%) in group B, including 2 cases of pulmonary infection and 1 case of gastrointestinal bleeding. There was no significant difference in the incidence of complications between the two groups ( &lt;i&gt;χ&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt;=0.104, &lt;i&gt;P&lt;/i&gt;=0.747). There were 2 cases (8.0%) and 4 cases (26.7%) died within 1 year after operation in groups A and B, respectively, and there was no significant difference in 1-year mortality rates between the two groups ( &lt;i&gt;χ&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt;=2.562, &lt;i&gt;P&lt;/i&gt;=0.109).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Serum IL-6 levels significantly increase in the early postoperative period in elderly male patients with intertrochanteric fractures, especially in those with ","PeriodicalId":23979,"journal":{"name":"中国修复重建外科杂志","volume":"38 10","pages":"1249-1253"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142476237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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中国修复重建外科杂志
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