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Edoxaban in cardiovascular medicine from scientific evidence to clinical practice 依多沙班在心血管医学中的应用从科学证据到临床实践
Pub Date : 2022-11-15 DOI: 10.9739/tjvs.2022.09.019
A. Budak, T. Gençpınar, E. Dogan, Sahin Totan, H. T. Akay
Direct oral anticoagulants have become a reasonable treatment option replacing warfarin in preventing stroke in patients with non-valvular atrial fibrillation and in treating and preventing venous thromboembolism. This article aims to summarize the rationale behind the development of direct oral anticoagulants and to review the key pharmacological properties, clinical and reallife data of the factor Xa inhibitor edoxaban, that may contribute to improving patient outcomes in cardiovascular clinical practice.
直接口服抗凝剂已成为替代华法林预防非瓣膜性房颤患者脑卒中、治疗和预防静脉血栓栓塞的合理治疗选择。本文旨在总结直接口服抗凝剂发展的基本原理,并回顾Xa因子抑制剂依多沙班的关键药理学特性、临床和现实数据,这些数据可能有助于改善心血管临床实践中的患者预后。
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引用次数: 0
Effect Of Surgical Techniques In The Treatment Of Small Saphenous Vein Insufficiency On Clinical Outcomes 小隐静脉不全手术治疗技术对临床疗效的影响
Pub Date : 2022-11-15 DOI: 10.9739/tjvs.2022.1304
A. Engin, F. Islamoglu
Effect Of Surgical Techniques In The Treatment Of Small Saphenous Vein Insufficiency On Clinical Outcomes
小隐静脉不全手术治疗技术对临床疗效的影响
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引用次数: 0
Patient blood management strategies in vascular surgery 血管外科患者血液管理策略
Pub Date : 2022-11-15 DOI: 10.9739/tjvs.2022.1299
Ş. Albeyoğlu
Transfusion of blood components can save lives, but like all therapeutics, it carries risks and costs. Therefore, transfusion should be used judiciously. Patient blood management provides safe and rational use of blood and blood products and is designed to improve patient outcomes by minimizing unnecessary exposure to blood products. In this review, perioperative patient blood management and techniques to minimize blood loss during vascular surgery are discussed.
输血可以挽救生命,但与所有治疗方法一样,它也有风险和成本。因此,输血应谨慎使用。患者血液管理提供安全和合理的血液和血液制品使用,旨在通过尽量减少不必要的血液制品接触来改善患者的预后。在这篇综述中,讨论了围手术期患者的血液管理和技术,以减少血管手术期间的失血。
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引用次数: 0
Endovascular aortic repair via carbon-dioxide imaging in renal insufficiency? 血管内主动脉瓣二氧化碳显像修复肾功能不全?
Pub Date : 2022-11-15 DOI: 10.9739/tjvs.2022.09.015
S. Mola, G. Aşkın, Bahadir Aytekin, Sabir Hasanzade, Abdullah Kusay Girgin, Naim Boran Tumer, E. Unal, H. Iscan
Aim: In our study, we aimed not only if CO2 is a safe and effective vascular roadmap for EVAR procedure instead of ICM but if it is a feasible opportunity for patients with hostile neck anatomy as well. Material and Methods: From January 2019 to July 2022, 42 patients with renal insufficiency had elective EVAR procedures for infrarenal abdominal aortic aneurysm in our Cardiovascular Surgery Clinic with CO2-guided DSA. Results: There were no conversions to open surgery or no need for ICM for the CO2-guided DSA. Technical success for CO2 guidance EVAR was 100% with the second shot. There was no decline in GFR values, only one patient showed transient manifestations of CIN without need for hemodialysis. Conclusion: CO2 DSA is a safe and effective technique that can guide not only the standard but endovascular procedures with a hostile neck for renal insufficiency below the diaphragm allowing virtually unlimited images. With modern automated closed systems, CO2-specific complications will be negligible if the operator has experience with the limitations and contraindications of the technique.
目的:在我们的研究中,我们不仅要研究CO2是否是EVAR手术安全有效的血管路线图,而不是ICM,而且对于颈部解剖不良的患者来说,是否是一个可行的机会。材料与方法:2019年1月至2022年7月,42例肾功能不全患者在我们的心血管外科诊所采用co2引导的DSA进行了选择性肾下腹主动脉瘤EVAR手术。结果:co2引导下的DSA没有转开手术,也不需要ICM。第二次发射时,CO2制导EVAR的技术成功率为100%。GFR值没有下降,只有1例患者出现短暂的CIN表现,无需血液透析。结论:CO2 DSA是一种安全有效的技术,不仅可以指导标准的血管内手术,而且可以指导膈肌以下肾功能不全的恶性颈部手术,几乎可以获得无限的图像。使用现代自动化封闭系统,如果操作人员对该技术的局限性和禁忌症有经验,则二氧化碳特异性并发症可以忽略不计。
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引用次数: 1
Endovascular therapy in blunt traumatic aortic injuries 钝性外伤性主动脉损伤的血管内治疗
Pub Date : 2022-11-15 DOI: 10.9739/tjvs.2022.09.017
G. Aşkın, S. Mola, Bahadir Aytekin, Sabir Hasanzade, Naim Boran Tumer, H. L. Mavioğlu, H. Iscan
Aim: Blunt traumatic thoracic aortic injury (BTTAI) is a catastrophic life-threatening surgical emergency and the second most common cause of death in trauma patients. We retrospectively revealed our results for endovascularly treated BTTAI with early and long-term results. Material and Methods: During January 2009 and January 2022, patients from the emergency department with diagnosed BTTAI were retrospectively revealed. 38 patients all male except two, experienced BTTAI. 5 patients had grade IV, and 21 patients had grade III aortic injuries. Results: Mean age of the patients was 41.7±12.5 years. Technical success was 100%. Early mortality was 7.9%. The mean follow-up period was 49.7±18.3 months. In the follow-up period, there were no TEVAR-related complications. Conclusion: TEVAR is the most suitable treatment for BTTAI in the modern era. Left subclavian artery (LSA) intentional coverage may be performed however surgeon modified fenestrated stent graft (SMFSG) is an effective, economic, fast, and readily available technique for LSA revascularization without additional time.
目的:钝性外伤性胸主动脉损伤(BTTAI)是一种灾难性的危及生命的外科急诊,也是创伤患者死亡的第二大常见原因。我们回顾性地揭示了血管内治疗BTTAI的早期和长期结果。材料和方法:回顾性分析2009年1月至2022年1月期间急诊诊断为BTTAI的患者。38例患者除2例外均为男性。5例为IV级,21例为III级。结果:患者平均年龄41.7±12.5岁。技术上的成功率是100%。早期死亡率为7.9%。平均随访时间49.7±18.3个月。随访期间未发生tevar相关并发症。结论:TEVAR是现代治疗BTTAI最合适的方法。可以对左锁骨下动脉(LSA)进行有意覆盖,但外科医生改良的开窗支架(SMFSG)是一种有效、经济、快速、容易获得的技术,无需额外的时间即可实现左锁骨下动脉(LSA)的血运重建。
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引用次数: 1
Proximal venous outflow obstructions and transfemoral approach in patients with arteriovenous fistula 动静脉瘘患者近端静脉流出梗阻及经股入路
Pub Date : 2022-11-15 DOI: 10.9739/tjvs.2022.1260
Ersin Çelik, A. Çora
Congratulations to the authors for their effort [1]. Endovascular treatment for central venous occlusions, which cause many vascular access problems among hemodialysis patients, has increased in recent years. Although most of these procedures have been applied via forearm vessels, there were studies reporting the use of the transfemoral approach in complicated cases [2,3]. In the publication, the authors reported that they applied a fistulogram by using a 6 Fr sheath from forearm veins and diagnosed the occlusion site. After the fistulogram, the authors used transfemoral access for other invasive procedures not to injure forearm vessels. We conclude that the invasive endovascular procedures for treating the occluded segment could be completed via the same access point, and the transfemoral approach must not be a routine route for access and reserved for more complicated cases or when the forearm is unavailable.
对作者的努力表示祝贺[1]。中心静脉闭塞引起血液透析患者的许多血管通路问题,近年来血管内治疗增加。虽然这些手术大多是通过前臂血管进行的,但也有研究报道了在复杂病例中使用经股入路[2,3]。在该出版物中,作者报告说,他们使用前臂静脉的6fr鞘进行了瘘管造影,并诊断了闭塞部位。经瘘管造影后,作者使用经股通路进行其他侵入性手术,以免损伤前臂血管。我们的结论是,治疗闭塞段的侵入性血管内手术可以通过相同的接入点完成,而经股入路不应该是常规的入路,而应保留给更复杂的病例或当前臂不可用时。
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引用次数: 0
Pulmonary artery angiosarcoma mimicking chronic thromboembolic pulmonary hypertension 肺动脉血管肉瘤模拟慢性血栓栓塞性肺动脉高压
Pub Date : 2022-11-15 DOI: 10.9739/tjvs.2022.09.07
H. T. Akay, E. Ayva, I. Oguzulgen, Gokhan Kahraman, B. Gültekin, O. Hekimoglu
Pulmonary artery angiosarcoma (PAA) is an extremely rare malignancy that arises from endothelial cells. The pulmonary trunk is the most common anatomic site of these tumors. However, so far, there have only been a few examples of PAA reported. PAAs are aggressive and have a bad prognosis, thus early diagnosis is critical. In this study, we present the case of a 27-year-old male who was initially diagnosed with acute pulmonary thromboembolism (PTE) before being diagnosed with chronic thromboembolic pulmonary hypertension (CTEPH). Pulmonary endarterectomy was performed, and PAA was diagnosed histopathologically. The patient died three months after diagnosis.
肺动脉血管肉瘤(PAA)是一种极为罕见的恶性肿瘤,起源于内皮细胞。肺干是这些肿瘤最常见的解剖部位。然而,到目前为止,报道的PAA的例子很少。PAAs侵袭性强,预后差,因此早期诊断至关重要。在这项研究中,我们提出了一个27岁的男性谁最初被诊断为急性肺血栓栓塞症(PTE),然后被诊断为慢性血栓栓塞性肺动脉高压(CTEPH)。行肺动脉内膜切除术,组织病理学诊断为PAA。病人在确诊后三个月死亡。
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引用次数: 0
Association Of D-Dimer/Fibrinogen Ratio With Pulmonary Embolism In COVID-19 Patients d -二聚体/纤维蛋白原比值与COVID-19患者肺栓塞的关系
Pub Date : 2022-11-15 DOI: 10.9739/tjvs.2022.1261
A. Topçu, F. Yiğit, Gozde Ozturk Altunyurt, A. Batırel, M. Rabus
Aim: This study aimed to investigate whether the D-dimer / fibrinogen ratio (DDFR) measured on admission could be used as a diagnostic marker of pulmonary embolism (PE) in coronavirus disease 2019 (COVID-19) patients. Material and Methods: This single-center, retrospective, case-control study was conducted with 204 COVID-19 patients (131 males, 73 females; mean age: 62±15.4 years; range, 28 to 97 years) between October 18, 2020, and December 18, 2020. Patients were followed during the hospital stay and for 30 days after discharge. The primary outcome was the occurrence of radiologically confirmed PE. The DDFR was calculated using the following formula: DDFR=D-dimer (ng/mL) / fibrinogen (mg/dL). Results: Six (2.9%) patients experienced PE during the follow-up. D-dimer had 63.6% sensitivity and 76.2% specificity on admission to predict thromboembolism at a cut-off of 1,375 ng/mL (area under the curve (AUC)=0.687, 95% confidence interval (CI): 0.530-0.845, p<0.05). The DDFR had 75% sensitivity and 90.5% specificity on admission to predict thromboembolism at a cut-off of 5.41 (AUC =0.846, 95% CI: 0.728-0.965, p<0.05). Conclusion: A measurement of DDFR on admission does not provide incremental value over D-dimer to recognize patients who are at risk of developing PE during and early after hospitalization for COVID-19.
目的:探讨入院时测量的d -二聚体/纤维蛋白原比值(DDFR)是否可作为2019冠状病毒病(COVID-19)患者肺栓塞(PE)的诊断指标。材料与方法:本研究采用单中心、回顾性、病例对照研究,纳入204例COVID-19患者(男性131例,女性73例;平均年龄:62±15.4岁;2020年10月18日至2020年12月18日,时间范围28至97年。随访患者住院期间及出院后30天。主要结果是放射学证实的PE的发生。DDFR计算公式为:DDFR= d -二聚体(ng/mL) /纤维蛋白原(mg/dL)。结果:6例(2.9%)患者在随访期间出现PE。入院时d -二聚体预测血栓栓塞的敏感性为63.6%,特异性为76.2%,截止值为1375 ng/mL(曲线下面积(AUC)=0.687, 95%可信区间(CI): 0.530-0.845, p<0.05)。入院时DDFR预测血栓栓塞的敏感性为75%,特异性为90.5%,临界值为5.41 (AUC =0.846, 95% CI: 0.728-0.965, p<0.05)。结论:入院时的DDFR测量并不能提供比d -二聚体更大的价值,以识别在COVID-19住院期间和住院后早期有发生PE风险的患者。
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引用次数: 0
Rotational atherectomy for below the knee lesions in critical limb threatening ischemia: Is it a wild goose chase? 旋转动脉粥样硬化切除术治疗严重肢体缺血的膝以下病变:是徒劳的吗?
Pub Date : 2022-11-15 DOI: 10.9739/tjvs.2022.1301
Aysen Yaprak Engin, Deniz Şerefli
Aim: Treatment of infrapopliteal peripheral arterial disease is still challenging. Rotational atherectomy (RA) is a novel option that aims removal of calcium from the lumen and improvement in outcomes. Material and Methods: Data of 27 patients (19 males, 8 females; mean age: 59.8±13.7 years; range, 25 to 79 years) with infrapopliteal occlusions treated by RA between January 2017 and December 2019 was retrospectively collected. The Global Limb Anatomic Staging System (GLASS) and the Rutherford classification (RC) were used for evaluation. The objective performance goals of Conte et al. (major adverse limb event [MALE] and major adverse cardiovascular event [MACE]) were used for assessing outcome performance. Visits were scheduled at 1, 6, 12, 18, and 24 months after treatment. In each visit, symptoms, RC, wound status, smoking status, lifestyle modifications, and medications were questioned, laboratory tests and Doppler ultrasonography were carried out, and the next visit was planned. Results: Device success was 88.89%, whereas procedural success was 100%. Unanticipated amputation rate was 11.1% in the 12-month follow-up. Over half of the patients (66.67%) showed RC improvement with a mean change of 3±1.17. Thirty-day safety endpoints were as follows: MALE, MACE, and amputation rates were 12.5%, 0%, and 8.33%, respectively. One-year efficacy endpoints were as follows: freedom from MALE+perioperative death was 71.42%, amputation-free survival was 76.19%, freedom from reintervention (amputation was 75%, limb salvage was 80%, and survival was 90.47%. Associations between RC (5-6) and calcification, chronic renal insufficiency and amputation, being a nonsmoker and failure to improve RC, and smoking and high infrapopliteal GLASS were found. Smoking cessation came with RC improvement in every case. Nonquitters experienced worsening more often compared to quitters (0% vs. 25%). Conclusion: Rotational atherectomy is feasible and effective in infrapopliteal chronic total occlusions. Closer follow-up is suggested for nonsmokers and patients with chronic renal insufficiency or advanced GLASS stages as they are prone to unfavorable clinical results. Quitting smoking should be underlined with its potential positive clinical effect even after the procedure.
目的:髌下外周动脉疾病的治疗仍然具有挑战性。旋转动脉粥样硬化切除术(RA)是一种新颖的选择,旨在从腔内去除钙并改善预后。材料与方法:27例患者资料(男19例,女8例;平均年龄59.8±13.7岁;回顾性收集2017年1月至2019年12月期间接受RA治疗的髌下闭塞患者。采用全球肢体解剖分期系统(GLASS)和Rutherford分类(RC)进行评估。采用Conte等人的客观表现目标(主要肢体不良事件[MALE]和主要心血管不良事件[MACE])评估结局表现。随访时间分别为治疗后1、6、12、18和24个月。每次就诊时,询问症状、RC、伤口状况、吸烟状况、生活方式改变和药物,进行实验室检查和多普勒超声检查,并计划下一次就诊。结果:器械成功率为88.89%,手术成功率为100%。随访12个月,意外截肢率为11.1%。超过一半(66.67%)的患者RC改善,平均变化为3±1.17。30天的安全终点如下:MALE、MACE和截肢率分别为12.5%、0%和8.33%。1年疗效终点为:男性男性患者+围手术期死亡发生率为71.42%,无截肢生存率为76.19%,无再干预(截肢率为75%,肢体保留率为80%,生存率为90.47%)。研究发现RC(5-6)与钙化、慢性肾功能不全和截肢、不吸烟和改善RC失败、吸烟和高腘下GLASS之间存在关联。在每一种情况下,戒烟都会带来RC的改善。与戒烟者相比,不戒烟者更容易出现病情恶化(0% vs. 25%)。结论:旋转动脉粥样硬化切除术治疗膝下慢性全闭塞是可行且有效的。建议对不吸烟者和慢性肾功能不全或晚期GLASS患者进行更密切的随访,因为他们容易出现不利的临床结果。即使在手术后,戒烟也应强调其潜在的积极临床效果。
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引用次数: 0
The relationship between platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio and prognosis in carotid artery endarterectomy 颈动脉内膜切除术中血小板与淋巴细胞比值、中性粒细胞与淋巴细胞比值与预后的关系
Pub Date : 2022-06-08 DOI: 10.9739/tjvs.2022.1143
Tolga Baş
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引用次数: 1
期刊
Turkish Journal of Vascular Surgery
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