首页 > 最新文献

Ageing Science & Mental Health Studies最新文献

英文 中文
Learning to Remember: Early Stage Exploration of user Requirements in an Education APP 学会记忆:教育类APP用户需求的早期探索
Pub Date : 2019-03-25 DOI: 10.31038/asmhs.2019314
D. Moskowitz, A. Gere, H. Moskowitz
We present a new approach, Mind Genomics, to understanding the needs of prospective users with respect to a teaching APP designed to promote improved memorization of important texts. Using small-scale experiments, using the systematically varied messages in the form of stories or vignettes, Mind Genomics uncovers the customer-requirements of the APP. These vignettes are combinations of ideas about the product, its use, and the benefits to be obtained. The pattern of reactions to these vignettes reveals which specific features and benefits ‘drive interest.’ Mind Genomics does not require the respondent to intellectualize the need, an intellectualization which introduces response biases, and perhaps demand an answer that the respondent may not know. Rather, the deconstruction of the pattern of the immediate responses assigned almost automatically and without deep thinking, clearly reveals the underlying needs. The results from this small-scale study suggest three radically different mind-set segments. Mind Genomics, finds application where the respondent’s job is to make decisions, and where one would like to reduce the biases due to what the respondent expects the appropriate answer to be. We show how Mind Genomics can become an early-stage, rapid, affordable, and scalable system for deep understanding of human judgments.
我们提出了一种新的方法,心灵基因组学,来了解潜在用户对教学APP的需求,旨在促进重要文本的记忆。通过小规模实验,以故事或小插图的形式系统地使用各种信息,Mind Genomics揭示了客户对APP的需求。这些小插图是关于产品,其用途和可获得的好处的想法的组合。对这些小插曲的反应模式揭示了哪些特定的功能和好处吸引了人们的兴趣。“心智基因组学不要求被调查者将需求理智化,这种理智化会引入反应偏差,可能会要求被调查者给出一个可能不知道的答案。”相反,对即时反应模式的解构几乎是自动分配的,没有深入思考,清楚地揭示了潜在的需求。这项小规模研究的结果显示了三种截然不同的思维模式。Mind Genomics在被调查者的工作是做决定的地方找到了应用,人们希望减少由于被调查者期望的适当答案而产生的偏见。我们展示了心智基因组学如何成为一个早期的、快速的、负担得起的、可扩展的系统,用于深入理解人类的判断。
{"title":"Learning to Remember: Early Stage Exploration of user Requirements in an Education APP","authors":"D. Moskowitz, A. Gere, H. Moskowitz","doi":"10.31038/asmhs.2019314","DOIUrl":"https://doi.org/10.31038/asmhs.2019314","url":null,"abstract":"We present a new approach, Mind Genomics, to understanding the needs of prospective users with respect to a teaching APP designed to promote improved memorization of important texts. Using small-scale experiments, using the systematically varied messages in the form of stories or vignettes, Mind Genomics uncovers the customer-requirements of the APP. These vignettes are combinations of ideas about the product, its use, and the benefits to be obtained. The pattern of reactions to these vignettes reveals which specific features and benefits ‘drive interest.’ Mind Genomics does not require the respondent to intellectualize the need, an intellectualization which introduces response biases, and perhaps demand an answer that the respondent may not know. Rather, the deconstruction of the pattern of the immediate responses assigned almost automatically and without deep thinking, clearly reveals the underlying needs. The results from this small-scale study suggest three radically different mind-set segments. Mind Genomics, finds application where the respondent’s job is to make decisions, and where one would like to reduce the biases due to what the respondent expects the appropriate answer to be. We show how Mind Genomics can become an early-stage, rapid, affordable, and scalable system for deep understanding of human judgments.","PeriodicalId":243213,"journal":{"name":"Ageing Science & Mental Health Studies","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125946947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Mind Assesses Aggression – Russia vs the Ukraine: A Mind Genomics Exploration 思维评估侵略-俄罗斯对乌克兰:思维基因组学的探索
Pub Date : 2019-03-25 DOI: 10.31038/asmhs.2019315
A. Gere, Roger Shelley, Ryan Zemel, Petraq Papajorgji, Joshua Deitel, H. Moskowitz
We introduce a system to rapidly explore a topic, focusing both on the direct conscious judgment of information (cognition), and on the time it takes the mind to process the same information (neuroprocessing.) The system begins with the experimental design of easily constructed mixtures of messages. With human respondents, the system measures the cognitive response to these mixtures (ratings), and at the same time, the processing rate of these same mixtures (response-time to assign a rating.) The system is affordable and scalable, working with as few as 10 respondents to as many as several thousand. The outcome data reveal what messages are important, and the response-time to process these same messages. The analysis is virtually automatic, providing a simple, readily used new tool to study decision making. All the tools are standard, easily used by professionals and novices alike, with the results immediately presented in the format of data tables and a PowerPoint® report ready for distribution.
我们引入了一个系统来快速探索一个主题,既关注对信息的直接有意识判断(认知),也关注大脑处理相同信息所需的时间(神经处理)。该系统从易于构建的消息混合的实验设计开始。对于人类应答者,系统测量对这些混合物的认知反应(评级),同时测量这些相同混合物的处理速度(分配评级的响应时间)。该系统价格合理且可扩展,可用于最少10个应答者,最多可用于数千个应答者。结果数据揭示了哪些消息是重要的,以及处理这些相同消息的响应时间。分析实际上是自动的,为研究决策提供了一个简单、易于使用的新工具。所有工具都是标准的,专业人士和新手都可以轻松使用,结果立即以数据表和PowerPoint®报告的格式呈现,准备分发。
{"title":"The Mind Assesses Aggression – Russia vs the Ukraine: A Mind Genomics Exploration","authors":"A. Gere, Roger Shelley, Ryan Zemel, Petraq Papajorgji, Joshua Deitel, H. Moskowitz","doi":"10.31038/asmhs.2019315","DOIUrl":"https://doi.org/10.31038/asmhs.2019315","url":null,"abstract":"We introduce a system to rapidly explore a topic, focusing both on the direct conscious judgment of information (cognition), and on the time it takes the mind to process the same information (neuroprocessing.) The system begins with the experimental design of easily constructed mixtures of messages. With human respondents, the system measures the cognitive response to these mixtures (ratings), and at the same time, the processing rate of these same mixtures (response-time to assign a rating.) The system is affordable and scalable, working with as few as 10 respondents to as many as several thousand. The outcome data reveal what messages are important, and the response-time to process these same messages. The analysis is virtually automatic, providing a simple, readily used new tool to study decision making. All the tools are standard, easily used by professionals and novices alike, with the results immediately presented in the format of data tables and a PowerPoint® report ready for distribution.","PeriodicalId":243213,"journal":{"name":"Ageing Science & Mental Health Studies","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126227700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Initial Foray into a Social Issue of Expressing Feelings through Technology: A Mind Genomics Exploration 通过技术表达情感的社会问题的初步尝试:心灵基因组学的探索
Pub Date : 2019-02-25 DOI: 10.31038/asmhs.2019313
Camilla Habsburg-Lothringen, G. Gabay
This study assessed the variation of concerns about expressing emotions in social relations, emerging from the increasing use of smartphones. Fifty respondents from the continental U.S.A participated through an application of Mind-Genomics Science. Two mind-set segments emerged. People in the first mind-set were concerned about the increasingly use of smartphones for social interaction, and the need for instant feedback. People in this segment stressed the need to put on a mask when presenting only a happy successful face. This segment was also preoccupied with our changing language skills, and with the increasing lack of privacy because everything one with smartphones is trackable. People in the second mind-set segment expressed concerns regarding the negative social effects of using smartphones to express emotions: less interaction at meals, isolation from personal relationships, fewer expressions of feelings, losing patience more quickly, and emerging health issues. A PVI (personal viewpoint identifier) is presented to allow discovery of these two mind-sets among new individuals, enabling a deeper understanding of the mind-sets by future researchers.
这项研究评估了随着智能手机的使用越来越多,人们对社交关系中表达情感的担忧程度的变化。来自美国大陆的50名受访者通过心灵基因组学科学的应用程序参与了调查。出现了两种思维模式。第一种心态的人担心越来越多地使用智能手机进行社交互动,以及对即时反馈的需求。这个部分的人强调,当只展示一张快乐成功的脸时,需要戴上面具。这部分人还专注于我们不断变化的语言技能,以及越来越缺乏隐私,因为智能手机上的一切都是可追踪的。第二种心态的人对使用智能手机表达情绪的负面社会影响表示担忧:吃饭时互动减少,与个人关系隔离,情感表达减少,更快失去耐心,以及出现健康问题。提出了一种个人观点标识符(PVI),允许在新个体中发现这两种心态,从而使未来的研究人员能够更深入地了解心态。
{"title":"An Initial Foray into a Social Issue of Expressing Feelings through Technology: A Mind Genomics Exploration","authors":"Camilla Habsburg-Lothringen, G. Gabay","doi":"10.31038/asmhs.2019313","DOIUrl":"https://doi.org/10.31038/asmhs.2019313","url":null,"abstract":"This study assessed the variation of concerns about expressing emotions in social relations, emerging from the increasing use of smartphones. Fifty respondents from the continental U.S.A participated through an application of Mind-Genomics Science. Two mind-set segments emerged. People in the first mind-set were concerned about the increasingly use of smartphones for social interaction, and the need for instant feedback. People in this segment stressed the need to put on a mask when presenting only a happy successful face. This segment was also preoccupied with our changing language skills, and with the increasing lack of privacy because everything one with smartphones is trackable. People in the second mind-set segment expressed concerns regarding the negative social effects of using smartphones to express emotions: less interaction at meals, isolation from personal relationships, fewer expressions of feelings, losing patience more quickly, and emerging health issues. A PVI (personal viewpoint identifier) is presented to allow discovery of these two mind-sets among new individuals, enabling a deeper understanding of the mind-sets by future researchers.","PeriodicalId":243213,"journal":{"name":"Ageing Science & Mental Health Studies","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117276957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Resonates about Professional Caregiving in the Mind of the Ordinary Person? 普通人心中对专业护理的共鸣是什么?
Pub Date : 2019-02-25 DOI: 10.31038/asmhs.2019312
{"title":"What Resonates about Professional Caregiving in the Mind of the Ordinary Person?","authors":"","doi":"10.31038/asmhs.2019312","DOIUrl":"https://doi.org/10.31038/asmhs.2019312","url":null,"abstract":"","PeriodicalId":243213,"journal":{"name":"Ageing Science & Mental Health Studies","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124027559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between Body Composition and Disease Severity in Patients with Motor Neuron Disease / Amyotrophic Lateral Sclerosis 运动神经元病/肌萎缩性侧索硬化症患者身体成分与疾病严重程度的关系
Pub Date : 2019-02-12 DOI: 10.31038/asmhs.2019311
{"title":"Association between Body Composition and Disease Severity in Patients with Motor Neuron Disease / Amyotrophic Lateral Sclerosis","authors":"","doi":"10.31038/asmhs.2019311","DOIUrl":"https://doi.org/10.31038/asmhs.2019311","url":null,"abstract":"","PeriodicalId":243213,"journal":{"name":"Ageing Science & Mental Health Studies","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121491763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Career Outcomes for STEM, Social and Behavioral Sciences and Education Doctoral Alumni STEM、社会和行为科学与教育博士校友的职业成果
Pub Date : 2018-10-08 DOI: 10.31038/asmhs.2018233
A. Mathur, S. Lean, Natalie V Walker, M. Kohl, Mustafa Ziyad, A. Caño, Mary E Wood
Traditionally doctoral students are trained to pursue tenure-track positions in research-intensive institutions. However, a survey of 914 PhD alumni at a public research university in a diverse array of disciplines finds that students move across employment sectors over a 15-year period. This study used a three-tier taxonomy to classify both shortand long-term employment outcomes based on employment sector, career type and job sector for Science, Technology, Engineering and Mathematics (STEM) and Social and Behavioral Sciences and Education (SBSE) doctoral alumni. The study is unique in that demographic information such as race, gender and citizenship status and academic performance measures were examined to gain a deeper understanding of career trajectories. The findings indicate differing career paths based on demographic characteristics, but also finds there is no correlation between academic performance metrics such as GPA and GRE scores and job placements in academia or outside of academia. This has significant implications for doctoral training and suggests that graduate programs must prepare students for both academic and alternative careers, particularly as tenure-track positions and U.S. federal research dollars continue to shrink. This study also adds to a growing body of literature on the need for rigorous data collection, and transparency to help students make informed choices about PhD training and career pathways.
传统上,博士生接受的是在研究密集型机构寻求终身职位的培训。然而,一项针对一所公立研究型大学914名不同学科的博士校友的调查发现,学生们在15年的时间里在不同的就业领域流动。本研究采用三层分类法,根据就业部门、职业类型和工作部门,对科学、技术、工程和数学(STEM)和社会与行为科学与教育(SBSE)博士校友的短期和长期就业结果进行了分类。这项研究的独特之处在于,为了更深入地了解职业轨迹,研究了种族、性别、公民身份和学业成绩等人口统计信息。研究结果表明,基于人口统计学特征的职业道路不同,但也发现,GPA和GRE分数等学术表现指标与学术界或学术界以外的工作安排之间没有相关性。这对博士培训有着重要的影响,并表明研究生课程必须为学生的学术和其他职业做好准备,特别是在终身职位和美国联邦研究经费不断减少的情况下。这项研究也增加了越来越多的文献,表明需要严格的数据收集和透明度,以帮助学生在博士培训和职业道路方面做出明智的选择。
{"title":"Career Outcomes for STEM, Social and Behavioral Sciences and Education Doctoral Alumni","authors":"A. Mathur, S. Lean, Natalie V Walker, M. Kohl, Mustafa Ziyad, A. Caño, Mary E Wood","doi":"10.31038/asmhs.2018233","DOIUrl":"https://doi.org/10.31038/asmhs.2018233","url":null,"abstract":"Traditionally doctoral students are trained to pursue tenure-track positions in research-intensive institutions. However, a survey of 914 PhD alumni at a public research university in a diverse array of disciplines finds that students move across employment sectors over a 15-year period. This study used a three-tier taxonomy to classify both shortand long-term employment outcomes based on employment sector, career type and job sector for Science, Technology, Engineering and Mathematics (STEM) and Social and Behavioral Sciences and Education (SBSE) doctoral alumni. The study is unique in that demographic information such as race, gender and citizenship status and academic performance measures were examined to gain a deeper understanding of career trajectories. The findings indicate differing career paths based on demographic characteristics, but also finds there is no correlation between academic performance metrics such as GPA and GRE scores and job placements in academia or outside of academia. This has significant implications for doctoral training and suggests that graduate programs must prepare students for both academic and alternative careers, particularly as tenure-track positions and U.S. federal research dollars continue to shrink. This study also adds to a growing body of literature on the need for rigorous data collection, and transparency to help students make informed choices about PhD training and career pathways.","PeriodicalId":243213,"journal":{"name":"Ageing Science & Mental Health Studies","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127713503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Does flooring-type change the gait characteristics of the older adult? Analysis of balance and temporal-spatial gait parameters and ground reaction force 地板类型会改变老年人的步态特征吗?平衡与时空步态参数及地面反作用力分析
Pub Date : 2018-10-02 DOI: 10.31038/asmhs.2018234
{"title":"Does flooring-type change the gait characteristics of the older adult? Analysis of balance and temporal-spatial gait parameters and ground reaction force","authors":"","doi":"10.31038/asmhs.2018234","DOIUrl":"https://doi.org/10.31038/asmhs.2018234","url":null,"abstract":"","PeriodicalId":243213,"journal":{"name":"Ageing Science & Mental Health Studies","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131635433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accreditation in hospitals: Should we implement the same standards in different types of hospitals? The case of a mental health hospital 医院认证:不同类型的医院是否应该实行相同的标准?精神病院的案例
Pub Date : 2018-07-08 DOI: 10.31038/asmhs.2018232
Steiner-Lavi
In the era of implementing quality standards as a mandatory process toward licensing, we raise the issue of implementing a generic standards for hospitals, or organizations, in general. Should we set different standards for different types of hospitals that implement to standards? This case study explores the specific issues that raise the dilemma. Regarding the fact that this hospital is the first mental health hospital in Israel to adopt the quality standards, it is crucial to understand the issue of adjusting the solutions for quality care.
在实施质量标准作为强制许可程序的时代,我们提出了对医院或组织实施通用标准的问题。我们是否应该针对不同类型的执行标准的医院制定不同的标准?本案例研究探讨了引起这种困境的具体问题。鉴于这家医院是以色列第一家采用质量标准的精神卫生医院,了解调整质量护理解决方案的问题至关重要。
{"title":"Accreditation in hospitals: Should we implement the same standards in different types of hospitals? The case of a mental health hospital","authors":"Steiner-Lavi","doi":"10.31038/asmhs.2018232","DOIUrl":"https://doi.org/10.31038/asmhs.2018232","url":null,"abstract":"In the era of implementing quality standards as a mandatory process toward licensing, we raise the issue of implementing a generic standards for hospitals, or organizations, in general. Should we set different standards for different types of hospitals that implement to standards? This case study explores the specific issues that raise the dilemma. Regarding the fact that this hospital is the first mental health hospital in Israel to adopt the quality standards, it is crucial to understand the issue of adjusting the solutions for quality care.","PeriodicalId":243213,"journal":{"name":"Ageing Science & Mental Health Studies","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115633080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clarification of Research Study: ADHD Does Not Provide Special Conditions for Entrepreneurship 研究澄清:ADHD不为创业提供特殊条件
Pub Date : 1900-01-01 DOI: 10.31038/asmhs.2021518
{"title":"Clarification of Research Study: ADHD Does Not Provide Special Conditions for Entrepreneurship","authors":"","doi":"10.31038/asmhs.2021518","DOIUrl":"https://doi.org/10.31038/asmhs.2021518","url":null,"abstract":"","PeriodicalId":243213,"journal":{"name":"Ageing Science & Mental Health Studies","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122189231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellular Adaptation to Ischemia; Ischemic Conditioning to Confer Neuroprotective Benefits in Mild Cognitive Impairment and Alzheimer’s disease 细胞适应缺血;缺血性条件反射对轻度认知障碍和阿尔茨海默病具有神经保护作用
Pub Date : 1900-01-01 DOI: 10.31038/asmhs.2019325
N. Hess
Small, controlled doses of ischemia induced in a healthy limb has been demonstrated to strengthen the body’s tolerance to larger more toxic doses. Ischemic conditioning utilising protocols of remote ischemic conditioning (RIC) and physiological ischemic training (PIT) trigger mechanisms of cellular adaptation to ischemia. These protocols may represent practical and translatable therapies for neurological diseases, such as mild cognitive impairment and Alzheimer’s disease, that have an ischemic or inflammatory basis. Whilst the current literature supports the neuroprotective and anti-hypertensive effects of RIC and PIT, to date there has been no investigation into the effects of PIT utilising isometric exercise training (IET) on cognitive performance outcomes in an elderly neuropathological cohort. However, it seems feasible that the anti-hypertensive effects elicited through IET might be a stimulus for improvements in systemic and neurovascular circulation and as a result, enhanced cognitive performance.
在健康肢体中引起的小剂量、控制剂量的缺血已被证明可以增强身体对更大毒性剂量的耐受性。利用远程缺血调节(RIC)和生理缺血训练(PIT)协议的缺血调节触发细胞适应缺血的机制。这些方案可能代表了具有缺血性或炎症基础的神经系统疾病,如轻度认知障碍和阿尔茨海默病的实用和可翻译的治疗方法。虽然目前的文献支持RIC和PIT的神经保护和降压作用,但迄今为止还没有关于PIT利用等长运动训练(IET)对老年神经病理队列认知表现结果的影响的研究。然而,似乎可行的是,通过IET引起的降压作用可能是促进全身和神经血管循环的改善,从而增强认知能力。
{"title":"Cellular Adaptation to Ischemia; Ischemic Conditioning to Confer Neuroprotective Benefits in Mild Cognitive Impairment and Alzheimer’s disease","authors":"N. Hess","doi":"10.31038/asmhs.2019325","DOIUrl":"https://doi.org/10.31038/asmhs.2019325","url":null,"abstract":"Small, controlled doses of ischemia induced in a healthy limb has been demonstrated to strengthen the body’s tolerance to larger more toxic doses. Ischemic conditioning utilising protocols of remote ischemic conditioning (RIC) and physiological ischemic training (PIT) trigger mechanisms of cellular adaptation to ischemia. These protocols may represent practical and translatable therapies for neurological diseases, such as mild cognitive impairment and Alzheimer’s disease, that have an ischemic or inflammatory basis. Whilst the current literature supports the neuroprotective and anti-hypertensive effects of RIC and PIT, to date there has been no investigation into the effects of PIT utilising isometric exercise training (IET) on cognitive performance outcomes in an elderly neuropathological cohort. However, it seems feasible that the anti-hypertensive effects elicited through IET might be a stimulus for improvements in systemic and neurovascular circulation and as a result, enhanced cognitive performance.","PeriodicalId":243213,"journal":{"name":"Ageing Science & Mental Health Studies","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123419112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Ageing Science & Mental Health Studies
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1