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Dispersion compensation for optical coherence tomography 光学相干层析成像的色散补偿
Pub Date : 2010-03-25 DOI: 10.1117/12.863546
Ranida Wongpiya, W. Mohammed, S. Sherif
Optical coherence tomography (OCT) is an imaging technique widely used in various applications especially in biomedical field. It constructs a high resolution 3-D image using multiple cross-sectional views. The axial resolution can be degraded if the sample is dispersive, which is usually true as most of the samples are living tissues. For time-domain OCT, this dispersion is minimized numerically by introducing a compensation filter, which is applied to the obtained signal in Wigner domain, a time-frequency domain. The filter is designed using simulated annealing optimization technique. This paper shows the design of the filter and the results of dispersion compensation.
光学相干断层扫描(OCT)是一种广泛应用的成像技术,特别是在生物医学领域。它使用多个横断面视图构建一个高分辨率的三维图像。如果样品是分散的,轴向分辨率可能会降低,这通常是正确的,因为大多数样品是活组织。对于时域OCT,通过引入补偿滤波器,将得到的信号应用于Wigner域,即时频域,从而在数值上最小化色散。采用模拟退火优化技术设计了滤波器。文中给出了滤波器的设计和色散补偿的结果。
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引用次数: 1
Numerical simulations of electrokinetic transport of a particle in a microfluidic confined domain 微流体受限域中粒子电动力学输运的数值模拟
Pub Date : 2010-03-25 DOI: 10.1117/12.861523
Qian Liang, Cunlu Zhao, Chun Yang, J. Miao
The electrokinetic transport behaviors of a particle in a microfluidic confined domain under thin electrical double layer (EDL) assumption are investigated. The focus is placed on transport velocity development of the particle. A finite element method based numerical simulation is employed to solve the model. The results indicate that the particle's density, domain width and zeta potential ratio of the wall to the particle are important to the particle's migration. Moreover, the dynamic flow field and vortex evolution within the confined domain are examined. It is found that the translational migration of the particle is significantly affected by electroosmotic flow (EOF) induced vortex flow within the domain.
研究了在薄双电层(EDL)假设下微流体约束域中粒子的电动力学输运行为。重点放在粒子的传输速度发展上。采用基于数值模拟的有限元方法对模型进行求解。结果表明,粒子密度、畴宽和壁面与粒子的zeta电位比对粒子的迁移有重要影响。此外,还研究了密闭区域内的动态流场和涡的演化。研究发现,电渗透流(EOF)诱导的涡旋流对粒子的平动迁移有显著影响。
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引用次数: 0
Numerical modeling of scanning near-field optical microscopy for fluorescence-less DNA detection 扫描近场光学显微镜无荧光DNA检测的数值模拟
Pub Date : 2010-03-25 DOI: 10.1117/12.863533
Chanachai Poosri, Atikrit Chanjavanakul, W. Mohammed
Scanning near-field optical microscopy (SNOM) has gained wide interest as a viable microscopic technique for the study of surface properties at the nanoscale. SNOM uses optical fiber to detect evanescent wave which provides a high resolution imaging beyond the diffraction limit. The collected intensity is influenced by complex refractive index of the sample. This project exploits the property of evanescent wave to discriminate between unhybridized and hybridized DNA which has a significant difference in complex refractive index. The concept could become a promising alternative since it circumvents fluorescence-labeling problems. The research focuses on numerical modeling by mean of finitedifference beam propagation and DNA hybridization based on empirical data from literatures.
扫描近场光学显微镜(SNOM)作为研究纳米尺度表面性质的一种可行的显微技术已经引起了广泛的兴趣。SNOM利用光纤检测倏逝波,提供了超过衍射极限的高分辨率成像。采集强度受样品复折射率的影响。本项目利用倏逝波的特性来区分复折射率有显著差异的非杂化DNA和杂化DNA。这个概念可能成为一个很有前途的替代方案,因为它规避了荧光标记的问题。在文献经验数据的基础上,重点研究了有限差分光束传播和DNA杂交的数值模拟。
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引用次数: 0
Schematic-based 4/16/64 order quadrature amplitude modulation mapper-demapper implementation for 256 subchannel orthogonal frequency division multiplexing model on FPGA Xilinx SPARTAN 3E 基于原理图的4/16/64阶正交调幅映射器在Xilinx SPARTAN 3E FPGA上实现256子通道正交频分复用模型
Pub Date : 2010-03-25 DOI: 10.1117/12.863863
.. Imaduddin, Budi Setiyanto, .. Litasari
Orthogonal Frequency Division Multiplexing (OFDM) is a modulation technique which provides higher bit rate and efficient bandwidth. This paper presents an implementation of a 4/16/64 Order Quadrature Amplitude Modulation (QAM) Mapper-Demapper for 256 Sub channel OFDM Model on Xilinx SPARTAN 3E Field-Programmable Gate Array (FPGA) series, using schematic approach. This QAMOFDM model is reconfigurable in term of its QAM order. The result shows that under the clock frequency around 262 MHz, the implementation works well, high precision is achieved at its serial output. A precision process conducted at 20 ns internal clock input period, with the 25 Mbps input bit rate requires 81.94 μs QAM processing-time. The implementation consumes about 80 % of the total FPGA slices (3736 slices).
正交频分复用(OFDM)是一种能够提供更高比特率和高效带宽的调制技术。本文采用原理图方法,在Xilinx SPARTAN 3E现场可编程门阵列(FPGA)系列上实现了用于256子信道OFDM模型的4/16/64阶正交调幅(QAM)映射-解耦器。该QAMOFDM模型根据其QAM顺序可重构。结果表明,在时钟频率为262 MHz左右时,实现效果良好,串行输出精度较高。在20 ns的内部时钟输入周期下,以25 Mbps的输入比特率进行精确处理,需要81.94 μs QAM处理时间。该实现消耗了大约80%的FPGA片(3736片)。
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引用次数: 0
Vertically aligned silicon nanowires fabricated by electroless etching of silicon wafer 用化学刻蚀法制备垂直排列的硅纳米线
Pub Date : 2010-03-25 DOI: 10.1117/12.861353
S. D. Hutagalung, Agnes S. Y. Tan, R. Tan, Y. Wahab
Silicon nanowires were synthesized by electroless etching of Si(100) wafer using a mixture of hydrofluoric acid and silver nitrate. The formation of nanowires was catalyzed by silver nanoclusters deposit through an exchange reaction in which both silicon oxidation and silver reduction occur simultaneously on silicon surface. The etchant concentration, etching temperature and duration were well controlled in this work to produce a high aspect ratio of silicon nanowires. The morphological observation indicated that the fabricated silicon nanowires grown vertically on silicon surface. Moreover, a various shapes of rounded-, rectangular-, and triangle-shape are obtained co-exist in the bundle of silicon nanowires.
采用氢氟酸和硝酸银的混合物对硅(100)晶圆进行化学刻蚀,合成了硅纳米线。银纳米团簇沉积通过在硅表面同时发生硅氧化和银还原的交换反应催化纳米线的形成。通过对蚀刻剂浓度、蚀刻温度和时间的控制,制备出高纵横比的硅纳米线。形貌观察表明,制备的硅纳米线垂直生长在硅表面。此外,在硅纳米线束中还可以形成圆形、矩形和三角形等多种形状。
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引用次数: 4
Influence of palmitoyl pentapeptide and Ceramide III B on the droplet size of nanoemulsion 棕榈酰五肽和神经酰胺III B对纳米乳液滴大小的影响
Pub Date : 2010-03-25 DOI: 10.1117/12.862919
D. Sondari, A. Haryono, S. B. Harmami, A. Randy
The influence of the Palmitoyl Pentapeptide (PPp) and Ceramide IIIB (Cm III B) as active ingredients on the droplet size of nano-emulsion was studied using different kinds of oil (avocado oil, sweet almond oil, jojoba oil, mineral oil and squalene). The formation of nano-emulsions were prepared in water mixed non ionic surfactant/oils system using the spontaneous emulsification mechanism. The aqueous solution, which consist of water and Tween® 20 as a hydrophilic surfactant was mixed homogenously. The organic solution, which consist of oil and Span® 80 as a lipophilic surfactant was mixed homogenously in ethanol. Ethanol was used as a water miscible solvent, which can help the formation of nano-emulsion. The oil phase (containing the blend of surfactant Span® 80, ethanol, oil and active ingredient) and the aqueous phase (containing water and Tween® 20) were separately prepared at room temperatures. The oil phase was slowly added into aqueous phase under continuous mechanical agitation (18000 rpm). All samples were subsequently homogenized with Ultra-Turrax for 30 minutes. The characterizations of nano-emulsion were carried out using photo-microscope and particle size analyzer. Addition of active ingredients on the formation of nano-emulsion gave smallest droplet size compared without active ingredients addition on the formation of nano-emulsion. Squalene oil with Palmitoyl Pentapeptide (PPm) and Ceramide IIIB (Cm IIIB) gave smallest droplet size (184.0 nm) compared without Palmitoyl Pentapeptide and Ceramide IIIB (214.9 nm), however the droplets size of the emulsion prepared by the other oils still in the range of nano-emulsion (below 500 nm). The stability of nano-emulsion was observed using two methods. In one method, the stability of nano-emulsion was observed for three months at temperature of 5°C and 50°C, while in the other method, the stability nano-emulsion was observed by centrifuged at 12000 rpm for 30 minutes. Nanoemulsion with active ingredient was remained stable even when stored until three months. Coalescence process between the droplets was not occurred significantly and droplet size was still below 500 nm. Over all, the emulsion remained stable, even it was centrifuged at 12000 rpm for 30 minutes.
以不同油(鳄梨油、甜杏仁油、荷荷巴油、矿物油和角鲨烯)为原料,研究了棕榈酰五肽(PPp)和神经酰胺IIIB (Cm iib)作为活性成分对纳米乳液滴度的影响。采用自发乳化机理,在非离子表面活性剂/油的水混合体系中制备了纳米乳液。将水和作为亲水性表面活性剂的Tween®20组成的水溶液均匀混合。有机溶液由油和作为亲脂表面活性剂的Span®80组成,在乙醇中均匀混合。采用乙醇作为水混溶溶剂,有利于纳米乳液的形成。在室温下分别制备油相(含有表面活性剂Span®80、乙醇、油和活性成分的混合物)和水相(含有水和吐温®20)。在连续机械搅拌(18000 rpm)下将油相缓慢加入水相。所有样品随后用Ultra-Turrax均质30分钟。采用光镜和粒度分析仪对纳米乳液进行了表征。与未添加活性成分的纳米乳液形成相比,添加活性成分对纳米乳液形成的影响最小。添加棕榈酰五肽(PPm)和神经酰胺IIIB (Cm IIIB)的角鲨烯油的液滴尺寸最小(184.0 nm),而不添加棕榈酰五肽和神经酰胺IIIB (214.9 nm)的角鲨烯油制备的乳液液滴尺寸仍在纳米乳液范围内(小于500 nm)。采用两种方法观察纳米乳液的稳定性。一种方法是在5°C和50°C的温度下观察纳米乳液的稳定性3个月,另一种方法是在12000 rpm的转速下离心30分钟观察纳米乳液的稳定性。含有活性成分的纳米乳在保存3个月后仍能保持稳定。液滴之间没有发生明显的聚结过程,液滴尺寸仍在500 nm以下。总的来说,即使在12000转/分钟的转速下离心30分钟,乳状液仍然保持稳定。
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引用次数: 3
Fabrication of holographic lens as a coupling device in surface plasmon resonance biosensor 表面等离子体共振生物传感器耦合装置全息透镜的研制
Pub Date : 2010-03-25 DOI: 10.1117/12.860379
P. Junlabhut, S. Phoojaruenchanachai, W. Pecharapa, S. Boonruang
Holographic lens is proposed as a light coupling device integrated in surface plasmon resonance (SPR) biosensor chips to concise the SPR optical system. Having a sub-wavelength pattern with an asymmetric profile, the lens couples light via a first order wave which excites the surface plasmon wave along the sensing spot. The design and fabrication process are included in this work, where a laser interference lithography technique is utilized as it requires only single step to write a lens' pattern. The preliminary result indicates the first order wave with 20% diffraction efficiency.
提出将全息透镜作为集成在表面等离子体共振(SPR)生物传感器芯片中的光耦合器件,以简化SPR光学系统。透镜具有非对称的亚波长模式,通过一阶波耦合光,该波沿着传感点激发表面等离子体波。设计和制造过程包括在这项工作中,其中激光干涉光刻技术被利用,因为它只需要一个步骤来写透镜的图案。初步结果表明,一阶波的衍射效率为20%。
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引用次数: 3
Towards low-cost transpiration-based microfluidics 迈向低成本的基于蒸腾的微流体
Pub Date : 2010-03-25 DOI: 10.1117/12.863867
S. Murtyas
THE PHENOMENON OF TRANSPIRATION, WHICH COMBINES EVAPORATION AND CAPILLARITY, COULD BE USED TO AUTONOMOUSLY AND SPONTANEOUSLY DRIVE FLOWS IN PUMP-LESS MICROFLUIDICS. WHILE PREVIOUS STUDIES HAVE SHOWN DIVERSE EXPERIMENTAL APPLICATIONS, NO COMPREHENSIVE THEORETICAL ANALYSIS HAS BEEN DONE ON THESE PROCESSES. HERE WE PERFORM PARAMETRIC STUDIES ON THE SYSTEM, WITH EMPHASIS ON STUDYING THE FEASIBILITY OF A LOW-COST VERSION OF TRANSPIRATION-BASED MICROFLUIDICS, WHICH COULD BE FABRICATED USING INEXPENSIVE AND READILY AVAILABLE MATERIALS (E.G. COTTON THREADS AND TISSUE PAPERS). OUR ANALYSIS IS PARTICULARLY FOCUSED ON THE GEOMETRIC VARIATION OF THE SYSTEM, INCLUDING THE RATIO BETWEEN CROSS SECTIONAL AREA OF CAPILARRITY PARTS AND EVAPORATION PARTS, AS WELL AS THE WIND VELOCITY AT THE INTERFACE BETWEEN THE EVAPORATOR AND ITS SURROUNDING AMBIENCE. OUR RESULTS SERVE AS GENERAL DESIGN GUIDES FOR LOW-COST TRANSPIRATION-BASED MICROFLUIDICS.
蒸腾现象结合了蒸发和毛细作用,可以用来自主和自发地驱动无泵微流体中的流动。虽然以前的研究显示了不同的实验应用,但没有对这些过程进行全面的理论分析。在这里,我们对该系统进行了参数化研究,重点研究了基于蒸腾的低成本微流体的可行性,该微流体可以使用廉价且容易获得的材料(例如棉线和薄纸)制造。我们的分析特别集中在系统的几何变化上,包括毛细管部分和蒸发部分的横截面积之比,以及蒸发器与其周围环境交界处的风速。我们的研究结果为低成本的基于蒸腾的微流体设计提供了一般指导。
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引用次数: 0
Asymmetric brightness of transparent organic emitting device with passivation layer by annealing 采用退火方法制备具有钝化层的透明有机发光器件的非对称亮度
Pub Date : 2010-03-25 DOI: 10.1117/12.862637
Chan-Jae Lee, D. Choi, Jeongno Lee
We studied transparent organic light emitting diode (TOLED) with semitransparent cathode, Ca-Ag and optical enhanced passivation layer by annealing. The 8-hydroxyquinolatolithium (Liq) passivation layer improves the stability of Ca/Ag double layer, resulting in substantial increase of the efficiency by the enhanced transmittance and change brightness as electrode. Fabricated device was composed as followed structure, glass/ITO/2TNATA/α-NPD/Alq3:C545T (1%)/Bebq2/Ca-Ag. The passivation layer, Liq (40nm) was deposited on the device without broken vacuum before encapsulation with transparent glass sheets. Thermal annealing was carried out in oven at 80oC after encapsulation. At the device without passivation layer, annealing process made device to be deteriorated, such as to increase driving voltage from 6.8 V to 9.0 V at 10 mA/cm2 and to drop efficiency 14.89 cd/A to 10.81 cd/A as bottom view. This drop of properties was caused by oxidation of cathode. However, the organic passivation layer played enough roles to protect oxidation of cathode. The efficiency as bottom side view of device with passivation layer, it can be observed that the efficiency and driving voltage were improved from 13.95 cd/A (@ 6.45 V) to 15.32 cd/A (@ 4.60 V) at 10 mA/cm2 by annealing. Annealing process, in the device with passivation layer, made to increase the asymmetry of brightness through anode and cathode. So the ratio BBot/BTop of the emitted light through each electrode was changed from 2.26 to 4.33.
本文研究了具有半透明阴极、Ca-Ag和光增强钝化层的透明有机发光二极管(TOLED)。8-羟基喹啉酸锂(Liq)钝化层提高了Ca/Ag双层的稳定性,通过提高透光率和改变电极亮度来大幅提高效率。制备的器件结构为:玻璃/ITO/2TNATA/α-NPD/Alq3:C545T (1%)/Bebq2/Ca-Ag。钝化层Liq (40nm)在不破真空的情况下沉积在器件上,然后用透明玻璃片封装。封装后在80℃的烘箱中进行热退火。在无钝化层的器件上,退火工艺使器件劣化,如驱动电压从6.8 V以10 mA/cm2的速度提高到9.0 V,效率从底图的14.89 cd/A下降到10.81 cd/A。性能的下降是由于阴极氧化引起的。而有机钝化层对阴极的氧化起到了足够的保护作用。从带钝化层器件的底面图可以看出,在10 mA/cm2时,效率和驱动电压从13.95 cd/A (@ 6.45 V)提高到15.32 cd/A (@ 4.60 V)。在带有钝化层的器件中进行退火处理,通过阳极和阴极增加亮度的不对称性。因此,每个电极发射光的BBot/BTop比值从2.26变化到4.33。
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引用次数: 0
Creating a smart environment using optical wireless 利用光学无线创造智能环境
Pub Date : 2010-03-25 DOI: 10.1117/12.863455
C. Viphavakit, M. Sohail, N. Shrestha, P. Saengudomlert, W. Mohammed
From the past until now, a radio frequency technology takes an important role in a communication system. Optical wireless technology is gaining more importance and becoming a smart alternative in the communication systems since noise and interference problem issues can be minimized. This project aims to create a smart environment by using optical wireless technology with a color multiplexing scheme. RGB Light Emitting Diodes (RGB-LEDs) are used as a visible white light source as they are becoming the next generation of lamps. A color de-multiplexing scheme is applied at the receiver port.
从过去到现在,射频技术在通信系统中起着重要的作用。由于噪声和干扰问题可以最小化,光学无线技术在通信系统中变得越来越重要,并成为一种智能的替代方案。该项目旨在通过使用具有彩色多路复用方案的光学无线技术来创建智能环境。RGB发光二极管(RGB- led)被用作可见的白光光源,因为它们正在成为下一代灯。在接收端采用彩色解复用方案。
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引用次数: 0
期刊
Southeast Asian International Advances in Micro/Nano-technology
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