Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.14
S. Tanumihardja, D. Supantini, J. Gunadi, A. Sanjaya, Katherine Marcella
Mechanical damage to nerve fibers during scoliosis correction can result in severe neurological disorders. It has been demonstrated that intraoperative neurophysiological monitoring during spinal surgery reduces the risk of motor deficits or paraplegia. Despite significant advances in the technique and application of IONM (intraoperative neurophysiological monitoring), data reporting the impact of implementing intraoperative neurophysiological monitoring on scoliosis surgery intervention remains very limited. Therefore, this review aims to investigate the correlation between the application of IONM and the risk of neurologic deficits in scoliosis patients undergoing surgery. The database sourced from PubMed (Jan 2010 to Jan 2022) was used to identify all studies evaluating the effectiveness and impact of intraoperative neurophysiological monitoring during scoliosis surgery and reducing the risk of postoperative complications. This systematic review included five studies. Multimodal IONM, with its high sensitivity and specificity, provides an objective benchmark that surgeons can implement to review surgical strategies to reduce the risk of permanent neurologic deficits. Multimodal IONM can be considered the gold standard of IONM in scoliosis surgery to prevent neurological damage and provide a more satisfactory result of surgical intervention.
{"title":"CLINICAL SIGNIFICANCE OF INTRAOPERATIVE NEUROPHYSIOLOGICAL MONITORING DURING SCOLIOSIS SURGERY: A LITERATURE REVIEW","authors":"S. Tanumihardja, D. Supantini, J. Gunadi, A. Sanjaya, Katherine Marcella","doi":"10.21776/ub.mnj.2023.009.02.14","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.14","url":null,"abstract":"Mechanical damage to nerve fibers during scoliosis correction can result in severe neurological disorders. It has been demonstrated that intraoperative neurophysiological monitoring during spinal surgery reduces the risk of motor deficits or paraplegia. Despite significant advances in the technique and application of IONM (intraoperative neurophysiological monitoring), data reporting the impact of implementing intraoperative neurophysiological monitoring on scoliosis surgery intervention remains very limited. Therefore, this review aims to investigate the correlation between the application of IONM and the risk of neurologic deficits in scoliosis patients undergoing surgery. The database sourced from PubMed (Jan 2010 to Jan 2022) was used to identify all studies evaluating the effectiveness and impact of intraoperative neurophysiological monitoring during scoliosis surgery and reducing the risk of postoperative complications. This systematic review included five studies. Multimodal IONM, with its high sensitivity and specificity, provides an objective benchmark that surgeons can implement to review surgical strategies to reduce the risk of permanent neurologic deficits. Multimodal IONM can be considered the gold standard of IONM in scoliosis surgery to prevent neurological damage and provide a more satisfactory result of surgical intervention.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122754363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.12
Rislan Faiz Muhammad, Basyar Adnani, Safira Dita Arviana, Aldita Husna Violita, H. Khotimah, S. Kurniawan, M. Syaban, Y. Yueniwati, Masruroh Rahayu
Background: Stroke, particularly ischemic stroke, is one of the leading causes of death worldwide. Ischemic stroke causes a failure of oxidative phosphorylation and ATP synthesis, resulting in high levels of reactive oxygen species (ROS), neuroinflammatory responses, and apoptosis, all of which result in cell death. Neuroprotective agents are given to prevent the infarct area from expanding. Objective: This study aims to predict an in silico interaction by 7,8-dihydroxyflavone as neuprotective agent through TrkB signaling and inhibiting Glutaminase activity. Methods: In silico simulation with 7,8-dihydroxyflavone (DHF) as neuroprotective agent using PubChem, RCSB, Biovia Discovery Studio, PyRx, and PyMol software. This study analyzes the pharmacokinetics, pharmacodynamics, and protein-ligand interactions between 7,8-DHF as a ligand with TrkB (4AT5) and Glutaminase (5JYO) as protein target, compared to their native ligand. Results: 7,8 DHF binds to 4AT5 and 5JYO with lower bond energy (-9.4 Kcal/mol and -6.3 Kcal/mol, respectively) than the native ligand (-5 Kcal/mol and -5.9 Kcal/mol, respectively). It means that 7,8-DHF may increase protective mechanism. Conclusion: These findings tend to increase downstream signaling pathways, leading to increased TrkB expression, which induces protective mechanisms, and decreased glutamate expression, which reduces glutamate toxicity.
{"title":"BIOINFORMATICS STUDY OF 7,8-DIHYDROXYFLAVONE AS A NEUROPROTECTIVE AGENT IN ISCHEMIC STROKE VIA TRKB REGULATION AND GLUTAMINASE INHIBITION","authors":"Rislan Faiz Muhammad, Basyar Adnani, Safira Dita Arviana, Aldita Husna Violita, H. Khotimah, S. Kurniawan, M. Syaban, Y. Yueniwati, Masruroh Rahayu","doi":"10.21776/ub.mnj.2023.009.02.12","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.12","url":null,"abstract":"Background: Stroke, particularly ischemic stroke, is one of the leading causes of death worldwide. Ischemic stroke causes a failure of oxidative phosphorylation and ATP synthesis, resulting in high levels of reactive oxygen species (ROS), neuroinflammatory responses, and apoptosis, all of which result in cell death. Neuroprotective agents are given to prevent the infarct area from expanding. Objective: This study aims to predict an in silico interaction by 7,8-dihydroxyflavone as neuprotective agent through TrkB signaling and inhibiting Glutaminase activity. Methods: In silico simulation with 7,8-dihydroxyflavone (DHF) as neuroprotective agent using PubChem, RCSB, Biovia Discovery Studio, PyRx, and PyMol software. This study analyzes the pharmacokinetics, pharmacodynamics, and protein-ligand interactions between 7,8-DHF as a ligand with TrkB (4AT5) and Glutaminase (5JYO) as protein target, compared to their native ligand. Results: 7,8 DHF binds to 4AT5 and 5JYO with lower bond energy (-9.4 Kcal/mol and -6.3 Kcal/mol, respectively) than the native ligand (-5 Kcal/mol and -5.9 Kcal/mol, respectively). It means that 7,8-DHF may increase protective mechanism. Conclusion: These findings tend to increase downstream signaling pathways, leading to increased TrkB expression, which induces protective mechanisms, and decreased glutamate expression, which reduces glutamate toxicity.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123675576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.19
E. Tedyanto, Niken Pratiwi, I. Arimbawa, I. Widyadharma
Background: Segmental zoster paresis (SZP) is a very uncommon complication characterized by localized weakening of the upper or lower limbs. Case report: A 69-year-old man came with complaints of weakness in the right leg two months ago. He had weakness in his right leg after two days of having herpes on his right leg. There was paresthesia and hypesthesia on neurological examination according to the L1-L3 dermatome. Neurophysiology examination revealed a neuropathy in the right femoral nerve. Discussion: Varicella-zoster virus, being a neurotrophic virus, primarily invades and incubates in the dorsal root or cerebral ganglion nerve cells. Etiological investigations in SZP patients have revealed that the anterior root is the most prevalent location of inflammation and degeneration. Conclusion: SZP is a rare complication following VZV infection that can lead to misdiagnosis and overtreatment in clinical practice. The neurophysiological examination is very important in diagnosing segmental zoster paresis.
{"title":"THE IMPORTANT OF NEUROPHYSIOLOGY EXAMINATION IN DIAGNOSING SEGMENTAL ZOSTER PARESIS: CASE REPORT","authors":"E. Tedyanto, Niken Pratiwi, I. Arimbawa, I. Widyadharma","doi":"10.21776/ub.mnj.2023.009.02.19","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.19","url":null,"abstract":"Background: Segmental zoster paresis (SZP) is a very uncommon complication characterized by localized weakening of the upper or lower limbs. Case report: A 69-year-old man came with complaints of weakness in the right leg two months ago. He had weakness in his right leg after two days of having herpes on his right leg. There was paresthesia and hypesthesia on neurological examination according to the L1-L3 dermatome. Neurophysiology examination revealed a neuropathy in the right femoral nerve. Discussion: Varicella-zoster virus, being a neurotrophic virus, primarily invades and incubates in the dorsal root or cerebral ganglion nerve cells. Etiological investigations in SZP patients have revealed that the anterior root is the most prevalent location of inflammation and degeneration. Conclusion: SZP is a rare complication following VZV infection that can lead to misdiagnosis and overtreatment in clinical practice. The neurophysiological examination is very important in diagnosing segmental zoster paresis.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133165281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.16
Alejandro Checa
Background: EMDR (eye movement desensitization and reprocessing) is a structured psychotherapy method that facilitates the treatment of various psychopathologies and problems related to both traumatic events and more common but emotionally stressful experiences.1 Due to the confinement due to the COVID-19 (Coronavirus Disease 2019) pandemic, people have developed a mixture of anticipatory anxiety, stress, tiredness, misunderstanding and fear, a psychological and emotional mixture that does not fit into any of the existing boxes in the classification of mental disorders.2 Eye Movement Desensitization and Reprocessing (EMDR) has abundant evidence of efficacy in trauma spectrum disorders. Its efficacy in anxious and depressive disorders in children and adolescents has been scarcely studied.3 Objective: To evaluate the efficacy of an alternative EMDR protocol. Methods: It is about a 13-year-old female adolescent who seeks care after having made her second suicide attempt after 9 months of failed psychological and psychiatric therapy, the standard EMDR protocol is executed in a first unsuccessful session and a variant of the EMDR protocol that occurred incidentally achieving the therapeutic goal. Results: This is an adolescent with a history of failed mental health treatment, the standard intervention protocol with EMDR was executed without success, however; In a second attempt, the patient spontaneously proceeds with desensitization from positive experiences without ever directly addressing the traumatic event. In this case, the reprocessing of the events occurred through positive experiences for the patient instead of what is indicated in the standard protocol where the trauma is reprocessed through the negative event. Conclusion: Psychological treatment using EMDR was effective despite its atypical execution, therefore variations to the original protocol can be applied.
{"title":"PSYCHOLOGICAL TREATMENT VARIANT WITH EYE MOVEMENT DESENSITIZATION AND REPROCESSING: A CASE REPORT","authors":"Alejandro Checa","doi":"10.21776/ub.mnj.2023.009.02.16","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.16","url":null,"abstract":"Background: EMDR (eye movement desensitization and reprocessing) is a structured psychotherapy method that facilitates the treatment of various psychopathologies and problems related to both traumatic events and more common but emotionally stressful experiences.1 Due to the confinement due to the COVID-19 (Coronavirus Disease 2019) pandemic, people have developed a mixture of anticipatory anxiety, stress, tiredness, misunderstanding and fear, a psychological and emotional mixture that does not fit into any of the existing boxes in the classification of mental disorders.2 Eye Movement Desensitization and Reprocessing (EMDR) has abundant evidence of efficacy in trauma spectrum disorders. Its efficacy in anxious and depressive disorders in children and adolescents has been scarcely studied.3 Objective: To evaluate the efficacy of an alternative EMDR protocol. Methods: It is about a 13-year-old female adolescent who seeks care after having made her second suicide attempt after 9 months of failed psychological and psychiatric therapy, the standard EMDR protocol is executed in a first unsuccessful session and a variant of the EMDR protocol that occurred incidentally achieving the therapeutic goal. Results: This is an adolescent with a history of failed mental health treatment, the standard intervention protocol with EMDR was executed without success, however; In a second attempt, the patient spontaneously proceeds with desensitization from positive experiences without ever directly addressing the traumatic event. In this case, the reprocessing of the events occurred through positive experiences for the patient instead of what is indicated in the standard protocol where the trauma is reprocessed through the negative event. Conclusion: Psychological treatment using EMDR was effective despite its atypical execution, therefore variations to the original protocol can be applied.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128843600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.7
Kharisma Ridho Husodo
Background: Physician burnout is a common problem seen in health workers, especially doctors and it is characterized by emotional exhaustion, depersonalization, and reduced personal accomplishment in daily work. The pandemic of Corona Virus Disease 2019 (COVID-19) causes an increase in the workload among doctors which will affect the incidence of Burnout. Burnout not only includes psychological problems, but also has a risk for physical disorders including pain disorders. Objective: To investigate the association of burnout level with headache and low back pain among physicians at Yogyakarta Islamic Hospital PDHI. Methods: This research design was a descriptive analytic study with a cross-sectional design. The subjects in this study were 46 doctors who worked at the Yogyakarta Islamic Hospital PDHI. Burnout levels were assessed using the Maslach Burnout Inventory (MBI) test. The incidence of headache and its impact on daily activities were assessed using the Headache Impact Test (HIT-6) questionnaire while Low Back Pain was assessed using Oswestry Disability Index (ODI). Results: Among burnout parameters, depersonalization was the most influential parameter which caused burnout. COVID-19 pandemic gave more impact to burnout level. The headache and low back pain incidence were 39,1% (18 subjects) and 43,4% (20 subjects) respectively. There were significant correlations between headache and every burnout parameter. Low back pain also had significant correlations to each burnout parameters. Conclusion: There was association of Burnout level with headache and low back pain incidence among physicians.
{"title":"ASSOCIATION OF PHYSICIAN BURNOUT WITH HEADACHE AND LOW BACK PAIN DURING PANDEMIC COVID-19","authors":"Kharisma Ridho Husodo","doi":"10.21776/ub.mnj.2023.009.02.7","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.7","url":null,"abstract":"Background: Physician burnout is a common problem seen in health workers, especially doctors and it is characterized by emotional exhaustion, depersonalization, and reduced personal accomplishment in daily work. The pandemic of Corona Virus Disease 2019 (COVID-19) causes an increase in the workload among doctors which will affect the incidence of Burnout. Burnout not only includes psychological problems, but also has a risk for physical disorders including pain disorders. Objective: To investigate the association of burnout level with headache and low back pain among physicians at Yogyakarta Islamic Hospital PDHI. Methods: This research design was a descriptive analytic study with a cross-sectional design. The subjects in this study were 46 doctors who worked at the Yogyakarta Islamic Hospital PDHI. Burnout levels were assessed using the Maslach Burnout Inventory (MBI) test. The incidence of headache and its impact on daily activities were assessed using the Headache Impact Test (HIT-6) questionnaire while Low Back Pain was assessed using Oswestry Disability Index (ODI). Results: Among burnout parameters, depersonalization was the most influential parameter which caused burnout. COVID-19 pandemic gave more impact to burnout level. The headache and low back pain incidence were 39,1% (18 subjects) and 43,4% (20 subjects) respectively. There were significant correlations between headache and every burnout parameter. Low back pain also had significant correlations to each burnout parameters. Conclusion: There was association of Burnout level with headache and low back pain incidence among physicians.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115801338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.4
Tuğba Turgut, R. Bahşi, D. Sürmeli, H. S. Öztorun, Çağlar Coşardereliğoğlu, Volkan Atmış, A. Yalçın, M. Varlı, S. Aras
Background: With aging, an increase is observed in some geriatric syndromes as well as sleep disorders. Objective: The aim of this study is to investigate the relationship between sleep quality and geriatric syndromes (dementia, depression, sarcopenia, malnutrition, and frailty) in nursing home residents. Methods: The participants’ demographic characteristics, comorbid diseases, number of drugs, cognitive performance, mood and nutritional states, sarcopenia and fraility screening tests and sleep quality test were evaluated by two geriatricians. The participants were divided into two groups as good sleep quality and poor sleep quality. Correlation analysis of sleep quality and geriatric and mental functionality tests was performed with Spearman correlation analysis. Results: A total of 104 nursing home residents (34 females, 74 males, aged 61-98) participated in the study. Sleep quality was found to be worse in the elderly between the ages of 75-84, with a higher number of children, using assistive devices, and taking selective serotonin reuptake inhibitors. In addition, in participants with poor sleep quality, SARC-f (strength, assistance with walking, rising from a chair, climbing stairs, and falls) and geriatric depression scale scores were significantly higher. The Pittsburgh Sleep Quality Index global score was negatively associated with total sleep time and positively associated with geriatric depression scale score and SARC-f score. Conclusion: Findings from the present study in relation between poor sleep quality and some geriatric evaluation parameters suggests that there may be a common pathophysiological alteration with aging.
{"title":"ASSOCIATION BETWEEN SLEEP QUALITY AND GERIATRIC SYNDROMES IN NURSING HOME RESIDENTS","authors":"Tuğba Turgut, R. Bahşi, D. Sürmeli, H. S. Öztorun, Çağlar Coşardereliğoğlu, Volkan Atmış, A. Yalçın, M. Varlı, S. Aras","doi":"10.21776/ub.mnj.2023.009.02.4","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.4","url":null,"abstract":"Background: With aging, an increase is observed in some geriatric syndromes as well as sleep disorders. Objective: The aim of this study is to investigate the relationship between sleep quality and geriatric syndromes (dementia, depression, sarcopenia, malnutrition, and frailty) in nursing home residents. Methods: The participants’ demographic characteristics, comorbid diseases, number of drugs, cognitive performance, mood and nutritional states, sarcopenia and fraility screening tests and sleep quality test were evaluated by two geriatricians. The participants were divided into two groups as good sleep quality and poor sleep quality. Correlation analysis of sleep quality and geriatric and mental functionality tests was performed with Spearman correlation analysis. Results: A total of 104 nursing home residents (34 females, 74 males, aged 61-98) participated in the study. Sleep quality was found to be worse in the elderly between the ages of 75-84, with a higher number of children, using assistive devices, and taking selective serotonin reuptake inhibitors. In addition, in participants with poor sleep quality, SARC-f (strength, assistance with walking, rising from a chair, climbing stairs, and falls) and geriatric depression scale scores were significantly higher. The Pittsburgh Sleep Quality Index global score was negatively associated with total sleep time and positively associated with geriatric depression scale score and SARC-f score. Conclusion: Findings from the present study in relation between poor sleep quality and some geriatric evaluation parameters suggests that there may be a common pathophysiological alteration with aging.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123112098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.15
Putu Yogi Pramana, Agung B S Satyarsa, I. Wijayanti, A. A. R. Sudewi
Background: Stem cells has previously been used with promising results as a therapeutic modality for neurodegenerative diseases and pain but has recently been introduced as a treatment for chronic pain. Objective: This study aims to review the available literature on the role of stem cell therapy as a treatment for chronic pain. Methods: A review of clinical reports using the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) method published in Pubmed, EMBASE (Excerpta Medica Database), and ScienceDirect were used from 2013 to 2023, and The search tool was used to locate and enroll patients for ongoing, presently active clinical studies. The search terms used included “chronic pain,” “therapy,” “prosedure” “neuropathic,” “discogenic,” “modality,” “musculoskeletal” and “stem cell.” The research was then carried out to assess the quality of the study using the Critical Appraisal Skills Program questionnaire. Results: There were around 186 studies related to the keyword, and only about 11 studies that met the inclusion criteria included in this article were obtained. Based on the results of the study, it was found that the role of stem cell therapy in the form of MSC and ADS, which was used, had a significant effect as a chronic pain therapy in patients. A decrease in the quality of pain was obtained based on VAS (Visual Analog Scale), ODI (Oswestry Disability Index), and NRS (Numeric Rating Scale) assessments as well as an increase in patient function. Conclusion: Although current research suggesting the use of mscs as a novel therapy method for disc, neuropathic, and musculoskeletal pain, further studies are required to demonstrate the efficacy as well as security of this modality
{"title":"THE POTENTIAL OF STEM CELL THERAPY AS A MANAGEMENT OF CHRONIC PAIN: A SYSTEMATIC REVIEW","authors":"Putu Yogi Pramana, Agung B S Satyarsa, I. Wijayanti, A. A. R. Sudewi","doi":"10.21776/ub.mnj.2023.009.02.15","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.15","url":null,"abstract":"Background: Stem cells has previously been used with promising results as a therapeutic modality for neurodegenerative diseases and pain but has recently been introduced as a treatment for chronic pain. Objective: This study aims to review the available literature on the role of stem cell therapy as a treatment for chronic pain. Methods: A review of clinical reports using the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) method published in Pubmed, EMBASE (Excerpta Medica Database), and ScienceDirect were used from 2013 to 2023, and The search tool was used to locate and enroll patients for ongoing, presently active clinical studies. The search terms used included “chronic pain,” “therapy,” “prosedure” “neuropathic,” “discogenic,” “modality,” “musculoskeletal” and “stem cell.” The research was then carried out to assess the quality of the study using the Critical Appraisal Skills Program questionnaire. Results: There were around 186 studies related to the keyword, and only about 11 studies that met the inclusion criteria included in this article were obtained. Based on the results of the study, it was found that the role of stem cell therapy in the form of MSC and ADS, which was used, had a significant effect as a chronic pain therapy in patients. A decrease in the quality of pain was obtained based on VAS (Visual Analog Scale), ODI (Oswestry Disability Index), and NRS (Numeric Rating Scale) assessments as well as an increase in patient function. Conclusion: Although current research suggesting the use of mscs as a novel therapy method for disc, neuropathic, and musculoskeletal pain, further studies are required to demonstrate the efficacy as well as security of this modality","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122623132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.8
Aldita Husna Violita, Safira Dita Arviana, Rislan Faiz Muhammad, Basyar Adnani, T. A. Wihastuti, H. Khotimah, S. Kurniawan, Y. Yueniwati
Background: Times New Roman 9, single space, contains the brief description of the research. Stroke is the greatest cause of disability and mortality worldwide. Several biological mechanisms underlying this disease such as failure of glutamate reuptake and ATP synthesis, resulting in high levels of reactive oxygen species (ROS), neuroinflammatory responses, and apoptosis, resulted in cell death and brain tissue damage. Neurotherapeutics agents are given to affect the pathophysiological pathways and prevent expanding infarct area. Objective: This study aims to analyze the modulation of Gluthatione S-Transferase (GST) and Tyrosine kinase receptor C (TrkC) by 7,8-DHF as neuroprotective agent in ischemic in silico. Methods: This study used in silico simulation to predict 7,8-dihydroxyflavone (DHF) as neuroprotective agent by using PubChem, RCSB, Biovia Discovery Studio, PyRx, and PyMol. This study analyzes the pharmacodynamics, pharmacokinetics, and molecular interactions between 7,8-DHF as a ligand with GST (13GS) and TrkC (6KZC) as protein target, compared to their native ligand. Results: 7,8-DHF may increase intracellular endogenous antioxidants mainly GST and stimulate TrkC to activate further neuron survival signaling. 7,8 DHF has a much lower bond energy (-8.1 Kcal/mol) when it binds to GST compared to the native ligand (-5.9 Kcal/mol). Besides, binding affinity between 7,8-DHF-TrkC was -9 Kcal/mol, while native ligand-TrkC was -10.6 Kcal/mol. This study showed that there were the same amino acid residues between 7,8-DHF-GST and 7,8-DHF-TrkC, compared to their native ligand. Conclusion: As an adaptive response to hypoxia caused by ischemic stroke, these findings are likely to induce protective mechanism through indirectly TrkC activation which regulates neurogenesis and increasing intracellular endogenous antioxidants.
{"title":"NEUROPROTECTANT OF 7,8-DIHYDROXYFLAVONE IN ISCHEMIC STROKE THROUGH MODULATION GLUTATHIONE S-TRANSFERASE AND TYROSINE RECEPTOR KINASE C: A BIOINFORMATICS STUDY","authors":"Aldita Husna Violita, Safira Dita Arviana, Rislan Faiz Muhammad, Basyar Adnani, T. A. Wihastuti, H. Khotimah, S. Kurniawan, Y. Yueniwati","doi":"10.21776/ub.mnj.2023.009.02.8","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.8","url":null,"abstract":"Background: Times New Roman 9, single space, contains the brief description of the research. Stroke is the greatest cause of disability and mortality worldwide. Several biological mechanisms underlying this disease such as failure of glutamate reuptake and ATP synthesis, resulting in high levels of reactive oxygen species (ROS), neuroinflammatory responses, and apoptosis, resulted in cell death and brain tissue damage. Neurotherapeutics agents are given to affect the pathophysiological pathways and prevent expanding infarct area. Objective: This study aims to analyze the modulation of Gluthatione S-Transferase (GST) and Tyrosine kinase receptor C (TrkC) by 7,8-DHF as neuroprotective agent in ischemic in silico. Methods: This study used in silico simulation to predict 7,8-dihydroxyflavone (DHF) as neuroprotective agent by using PubChem, RCSB, Biovia Discovery Studio, PyRx, and PyMol. This study analyzes the pharmacodynamics, pharmacokinetics, and molecular interactions between 7,8-DHF as a ligand with GST (13GS) and TrkC (6KZC) as protein target, compared to their native ligand. Results: 7,8-DHF may increase intracellular endogenous antioxidants mainly GST and stimulate TrkC to activate further neuron survival signaling. 7,8 DHF has a much lower bond energy (-8.1 Kcal/mol) when it binds to GST compared to the native ligand (-5.9 Kcal/mol). Besides, binding affinity between 7,8-DHF-TrkC was -9 Kcal/mol, while native ligand-TrkC was -10.6 Kcal/mol. This study showed that there were the same amino acid residues between 7,8-DHF-GST and 7,8-DHF-TrkC, compared to their native ligand. Conclusion: As an adaptive response to hypoxia caused by ischemic stroke, these findings are likely to induce protective mechanism through indirectly TrkC activation which regulates neurogenesis and increasing intracellular endogenous antioxidants.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122626279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.17
I. G. A. A. A. Yusari, P. Sudira, I. Wijayanti
Background: Schmorl’s node (SN) is described as intraosseous disc herniations which penetrate into the spinal canal, which is caused by the weakening of the cartilaginous endplate and subchondral bone. SN is usually detected on imaging which appears small, focal, and rounded with varying degrees of adjacent reactive sclerosis. Case Report: We present a rare case of symptomatic SN in 25-year-old male patient with complaints of discomfort and muscle strain in the back. These complaints were exacerbated by physical exercise. Severe tenderness was found at several levels of the thoracic vertebrae during palpation, where the trigger points were found in the lower trapezius muscle. Computerized tomography (CT) scan of the vertebra showed multiple bony lesions, noted as Schmorl’s nodes, at the inferior endplates of the T6-T11, and superior endplate of the T11 vertebra, in accordance to the location of severe pain during palpation. Conclusion: SN is associated with disc degeneration due to osteonecrosis process which leads to ischemia in the vertebral body. Microtrauma from excessive physical exercise could also contribute to the herniation through the weak points of the vertebral endplates. Knowledge and awareness of SN as one of the causes for acute or chronic back pain is essential for deciding early examination and diagnosis. Therefore, appropriate management could be delivered.
{"title":"MULTIPLE SCHMORL’S NODES ON YOUNG ADULT WITH MYOFASCIAL PAIN SYNDROME: A CASE REPORT","authors":"I. G. A. A. A. Yusari, P. Sudira, I. Wijayanti","doi":"10.21776/ub.mnj.2023.009.02.17","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.17","url":null,"abstract":"Background: Schmorl’s node (SN) is described as intraosseous disc herniations which penetrate into the spinal canal, which is caused by the weakening of the cartilaginous endplate and subchondral bone. SN is usually detected on imaging which appears small, focal, and rounded with varying degrees of adjacent reactive sclerosis. Case Report: We present a rare case of symptomatic SN in 25-year-old male patient with complaints of discomfort and muscle strain in the back. These complaints were exacerbated by physical exercise. Severe tenderness was found at several levels of the thoracic vertebrae during palpation, where the trigger points were found in the lower trapezius muscle. Computerized tomography (CT) scan of the vertebra showed multiple bony lesions, noted as Schmorl’s nodes, at the inferior endplates of the T6-T11, and superior endplate of the T11 vertebra, in accordance to the location of severe pain during palpation. Conclusion: SN is associated with disc degeneration due to osteonecrosis process which leads to ischemia in the vertebral body. Microtrauma from excessive physical exercise could also contribute to the herniation through the weak points of the vertebral endplates. Knowledge and awareness of SN as one of the causes for acute or chronic back pain is essential for deciding early examination and diagnosis. Therefore, appropriate management could be delivered.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"66 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114051943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.2
Vijetha Chanabasanavar
Background: Susceptibility Weighted Imaging (SWI) is a novel modality based upon GE (Gradient Echo) sequences that employ differences in susceptibility of various paramagnetic as well as diamagnetic substances that aid in the better diagnosis of various neurological entities such as intracranial tumors, vascular malformations, arterial stroke, venous hemorrhagic infarcts. Objective:To assess utility of SWI in various neurological diseases. Methods: The retrospective observational study was held in a tertiary care medical center in India in 2021. Multiple neurological diseases on SWI were analyzed in 100 patients with neurological complaints. The inclusion criteria included patient of all age group who presented with neurological signs and symptoms. The exclusion criteria included presence of post-operative non-compatible orthopedic hardware and patients with cardiac pacemakers, cochlear implants in situ. Results: The majority were males and > 60 years (23%) in age. Among 100 patients, most had tumors (18%), followed by trauma (16%), arterial stroke (15%), and hemorrhage (14%). Most of 14 patients with hemorrhage have intraparenchymal hemorrhage 9 (64.29%). There were10 patients with venous sinuses thrombosis and 15 cases with arterial stroke amongst whom most had middle cerebral artery thrombosis (46.66%). Most 13 patients with vascular pathologies had amyloid angiopathy 4 (30.77%). The majority of tumors were primary 15 (83.33%) with 10 (66.67%) newly diagnosed tumors, 11 (61.11%) tumors had a hemorrhage, 3 (16.67%) presented with calcification, and 4 (22.22%) had both hemorrhage and calcification. According to SWI grading of the tumor by intratumoral susceptibility score (ITSS), the majority were in grade III. On the correlation of SWI grading with MR Spectroscopy (MRS) and MR perfusion (MRP) study, 6 (100%) grade III patients showed hyperperfusion on MRP with raised choline/Creatinine ratio. SWI was better than CT (P<0.05) in detecting trauma, hemorrhage, cerebral venous sinus thrombosis, vascular pathologies, and tumors. Conclusion: SWI is a helpful imaging tool in neuroradiological practice and should be incorporated into standard procedures. It is beneficial in identifying hemorrhages, low-flow vascular abnormalities, diffuse axonal injury, and neurodegenerative illnesses. In addition, it is a supplementary sequence in the stroke by distinguishing calcium from hemorrhage in the brain and categorizing brain tumors.
{"title":"SUSCEPTIBILITY WEIGHTED IMAGING TECHNIQUE UTILITY IN DIVERSE NEUROLOGICAL ENTITIES","authors":"Vijetha Chanabasanavar","doi":"10.21776/ub.mnj.2023.009.02.2","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.2","url":null,"abstract":"Background: Susceptibility Weighted Imaging (SWI) is a novel modality based upon GE (Gradient Echo) sequences that employ differences in susceptibility of various paramagnetic as well as diamagnetic substances that aid in the better diagnosis of various neurological entities such as intracranial tumors, vascular malformations, arterial stroke, venous hemorrhagic infarcts. Objective:To assess utility of SWI in various neurological diseases. Methods: The retrospective observational study was held in a tertiary care medical center in India in 2021. Multiple neurological diseases on SWI were analyzed in 100 patients with neurological complaints. The inclusion criteria included patient of all age group who presented with neurological signs and symptoms. The exclusion criteria included presence of post-operative non-compatible orthopedic hardware and patients with cardiac pacemakers, cochlear implants in situ. Results: The majority were males and > 60 years (23%) in age. Among 100 patients, most had tumors (18%), followed by trauma (16%), arterial stroke (15%), and hemorrhage (14%). Most of 14 patients with hemorrhage have intraparenchymal hemorrhage 9 (64.29%). There were10 patients with venous sinuses thrombosis and 15 cases with arterial stroke amongst whom most had middle cerebral artery thrombosis (46.66%). Most 13 patients with vascular pathologies had amyloid angiopathy 4 (30.77%). The majority of tumors were primary 15 (83.33%) with 10 (66.67%) newly diagnosed tumors, 11 (61.11%) tumors had a hemorrhage, 3 (16.67%) presented with calcification, and 4 (22.22%) had both hemorrhage and calcification. According to SWI grading of the tumor by intratumoral susceptibility score (ITSS), the majority were in grade III. On the correlation of SWI grading with MR Spectroscopy (MRS) and MR perfusion (MRP) study, 6 (100%) grade III patients showed hyperperfusion on MRP with raised choline/Creatinine ratio. SWI was better than CT (P<0.05) in detecting trauma, hemorrhage, cerebral venous sinus thrombosis, vascular pathologies, and tumors. Conclusion: SWI is a helpful imaging tool in neuroradiological practice and should be incorporated into standard procedures. It is beneficial in identifying hemorrhages, low-flow vascular abnormalities, diffuse axonal injury, and neurodegenerative illnesses. In addition, it is a supplementary sequence in the stroke by distinguishing calcium from hemorrhage in the brain and categorizing brain tumors.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132237828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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