Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.9
Anindyta Murfia Khairunnisa, L. Amalia, E. B. Aristiady, H. G. Nugraha, Asep Nugraha Hermawan
Background: Stroke is the leading causes of death and disability in the world. Ischemic stroke covered 85% of stroke types. Based on the subtypes of ischemic stroke, lacunar ischemic stroke encompassed 20% of them. Knowing the characteristics help physicians to diagnose patients clinically and offer management to treat risk factors. Objective: This study aimed to know the characteristics of lacunar ischemic stroke based on patients risk factors, ischemic location on CT-scan, clinical syndrome, and NIHSS score. Methods: Using retrospective analytical study with cross sectional approach, medical record data from 2019-2022 were collected from RSUP DR. Hasan Sadikin Bandung. Results: From 60 patients, 35% (21) are 55-64 years old. Both sexes are equally distributed. 50 patients (83.3%) have multiple risk factors. Out of 60 patients, 57 (95%) have hypertension, 8 (13.3%) have diabetes mellitus, 44 (73.3%) have dyslipidemia, 6 (10%) have hyperuricemia, and 14 (23.3%) smoke. On admission, out of 60 patients, 34 (56.7%) have mild stroke, 23 (38.3%) have moderate stroke, 2 (3.3%) have moderate to severe stroke, and 1 (1.7%) has severe stroke. 44 (73.3%) out of 60 patients have pure motor hemiparesis. 41 (68.3%) out of 60 patients have basal ganglia ischemic. Conclusion: Lacunar ischemic stroke patients were equally distributed in sex with peak incidence occur between 55-64 years old. Most patients have multiple risk factors, basal ganglia lesion, pure motor hemiparesis, and history of hypertension, dyslipidemia, and smoking. On admission, most patients have mild stroke, followed by moderate stroke.
背景:中风是世界上导致死亡和残疾的主要原因。缺血性中风覆盖了85%的中风类型。从缺血性脑卒中亚型来看，腔隙性缺血性脑卒中占20%。了解这些特征有助于医生对患者进行临床诊断，并提供治疗危险因素的管理。目的:结合腔隙性缺血性脑卒中患者的危险因素、ct扫描缺血性部位、临床表现及NIHSS评分，了解腔隙性缺血性脑卒中的特点。方法:采用横断面回顾性分析方法，收集RSUP DR. Hasan Sadikin Bandung 2019-2022年的病历数据。结果:60例患者中，35例(21例)年龄在55 ~ 64岁之间。男女人数分布均匀。50例(83.3%)存在多重危险因素。60例患者中，高血压57例(95%)，糖尿病8例(13.3%)，血脂异常44例(73.3%)，高尿酸血症6例(10%)，吸烟14例(23.3%)。入院时60例患者中，轻度脑卒中34例(56.7%)，中度脑卒中23例(38.3%)，中重度脑卒中2例(3.3%)，重度脑卒中1例(1.7%)。单纯运动性偏瘫44例(73.3%)。60例患者中基底神经节缺血41例(68.3%)。结论:腔隙性缺血性脑卒中患者性别分布均匀，55 ~ 64岁为发病高峰。多数患者有多重危险因素，基底节病变、单纯运动性偏瘫、高血压、血脂异常、吸烟史。入院时，大多数患者有轻度中风，其次是中度中风。
{"title":"CLINICAL CHARACTERISTICS OF LACUNAR ISCHEMIC STROKE PATIENTS","authors":"Anindyta Murfia Khairunnisa, L. Amalia, E. B. Aristiady, H. G. Nugraha, Asep Nugraha Hermawan","doi":"10.21776/ub.mnj.2023.009.02.9","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.9","url":null,"abstract":"Background: Stroke is the leading causes of death and disability in the world. Ischemic stroke covered 85% of stroke types. Based on the subtypes of ischemic stroke, lacunar ischemic stroke encompassed 20% of them. Knowing the characteristics help physicians to diagnose patients clinically and offer management to treat risk factors. Objective: This study aimed to know the characteristics of lacunar ischemic stroke based on patients risk factors, ischemic location on CT-scan, clinical syndrome, and NIHSS score. Methods: Using retrospective analytical study with cross sectional approach, medical record data from 2019-2022 were collected from RSUP DR. Hasan Sadikin Bandung. Results: From 60 patients, 35% (21) are 55-64 years old. Both sexes are equally distributed. 50 patients (83.3%) have multiple risk factors. Out of 60 patients, 57 (95%) have hypertension, 8 (13.3%) have diabetes mellitus, 44 (73.3%) have dyslipidemia, 6 (10%) have hyperuricemia, and 14 (23.3%) smoke. On admission, out of 60 patients, 34 (56.7%) have mild stroke, 23 (38.3%) have moderate stroke, 2 (3.3%) have moderate to severe stroke, and 1 (1.7%) has severe stroke. 44 (73.3%) out of 60 patients have pure motor hemiparesis. 41 (68.3%) out of 60 patients have basal ganglia ischemic. Conclusion: Lacunar ischemic stroke patients were equally distributed in sex with peak incidence occur between 55-64 years old. Most patients have multiple risk factors, basal ganglia lesion, pure motor hemiparesis, and history of hypertension, dyslipidemia, and smoking. On admission, most patients have mild stroke, followed by moderate stroke.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131722448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.5
Jerome Constantine Lekatompessy, B. J. Que, L. Huwae
Background: Epilepsy in children causes memory problems in the learning process, so an early diagnosis of epilepsy is needed. The modality for determining the diagnosis of epilepsy is an electroencephalogram (EEG) examination. EEG recording results in epilepsy patients are epileptiform waves that can vary according to the type of epilepsy suffered. Objective: This study aims to determine the relationship of epileptiform waves on an electroencephalogram (EEG) with the type of epilepsy in school-age epilepsy patients. Methods: This study is an analytical study that uses secondary data in the form of medical records with cross sectional design. The research subjects were 106 patients taken with total sampling technique. Data collection is done by recording medical record data on the data collection form made by researchers. Correlation analysis between variables in this study used the Fisher test. Results: The results of this study indicate there is a relationship between epileptiform waves on the electroencephalogram (EEG) with the type of epilepsy in school-age epilepsy patients, with p = 0.018 in 0.050 significance value. Conclusion: It can be concluded that there is a correlation between epileptiform waves on an electroencephalogram (EEG) with the type of epilepsy in school-age epilepsy patients.
{"title":"THE RELATIONSHIP OF EPILEPTIFORM WAVES IN ELECTROENCEPHALOGRAM WITH EPILEPSY TYPE OF SCHOOL-AGE EPILEPSY PATIENTS","authors":"Jerome Constantine Lekatompessy, B. J. Que, L. Huwae","doi":"10.21776/ub.mnj.2023.009.02.5","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.5","url":null,"abstract":"Background: Epilepsy in children causes memory problems in the learning process, so an early diagnosis of epilepsy is needed. The modality for determining the diagnosis of epilepsy is an electroencephalogram (EEG) examination. EEG recording results in epilepsy patients are epileptiform waves that can vary according to the type of epilepsy suffered. Objective: This study aims to determine the relationship of epileptiform waves on an electroencephalogram (EEG) with the type of epilepsy in school-age epilepsy patients. Methods: This study is an analytical study that uses secondary data in the form of medical records with cross sectional design. The research subjects were 106 patients taken with total sampling technique. Data collection is done by recording medical record data on the data collection form made by researchers. Correlation analysis between variables in this study used the Fisher test. Results: The results of this study indicate there is a relationship between epileptiform waves on the electroencephalogram (EEG) with the type of epilepsy in school-age epilepsy patients, with p = 0.018 in 0.050 significance value. Conclusion: It can be concluded that there is a correlation between epileptiform waves on an electroencephalogram (EEG) with the type of epilepsy in school-age epilepsy patients.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134096347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.13
D. Utami, Faldi Yaputra
Disruptions in sleep-wake cycles are particularly prevalent after a Traumatic Brain Injury (TBI). Sleep disruptions may occur as a main impact of brain damage or as a result of other neuropsychiatric sequelae of TBI, such as anxiety disorder, depressive disorders, substance abuse, chronic pain, and/or medication consumption. Chronic discomfort (headache and broad pain, presumably of central origin) and/or sleep difficulties (insomnia, disturbed breathing, periodic limb movements) occur in about one in five people with TBI. Disruptions in sleep-wake cycles linked with TBI need therapy. Although data specific to individuals with TBI is currently limited, cognitive-behavioral treatment and medication may be beneficial in alleviating sleep-wake problems in people who have sustained a TBI. This article aims to raise awareness of sleep disturbance after TBI to enhance diagnosis, assessment, and therapy and disclose new research opportunities.
{"title":"SLEEP DISTURBANCE AFTER TRAUMATIC BRAIN INJURY: NEW INSIGHT","authors":"D. Utami, Faldi Yaputra","doi":"10.21776/ub.mnj.2023.009.02.13","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.13","url":null,"abstract":"Disruptions in sleep-wake cycles are particularly prevalent after a Traumatic Brain Injury (TBI). Sleep disruptions may occur as a main impact of brain damage or as a result of other neuropsychiatric sequelae of TBI, such as anxiety disorder, depressive disorders, substance abuse, chronic pain, and/or medication consumption. Chronic discomfort (headache and broad pain, presumably of central origin) and/or sleep difficulties (insomnia, disturbed breathing, periodic limb movements) occur in about one in five people with TBI. Disruptions in sleep-wake cycles linked with TBI need therapy. Although data specific to individuals with TBI is currently limited, cognitive-behavioral treatment and medication may be beneficial in alleviating sleep-wake problems in people who have sustained a TBI. This article aims to raise awareness of sleep disturbance after TBI to enhance diagnosis, assessment, and therapy and disclose new research opportunities.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"310 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115910312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.1
T. Kalekar, V. Rangankar, Pooja Karanjule, Radhika K. Jaipuria, Sahil Kathuria, Neeraj Patil, Giri Nk
Background: Mucormycosis is a fatal and progressive condition that affects immunocompromised patients in the post-COVID state. Radiological assessment by computed tomography and magnetic resonance imaging is useful to determine the severity and extent of the disease. Objective: The objective of this research is to evaluate mucormycosis in post-COVID patients using radiological investigations like computed tomography and magnetic resonance imaging and also to study the extent of disease in patients with diabetes and with steroid/ immunosuppressant use. Methods: A prospective observational study was undertaken at Dr. D. Y. Patil Hospital and Medical College, Pimpri Pune from March-June 2021. All patients who presented with mucormycosis were either COVID-19 positive or recovered from COVID-19 infection. Computed tomography and magnetic resonance imaging were performed in these patients. Results: The association between the status of diabetes mellitus and extent of involvement, steroids/immunosuppressant use and extent of involvement was statistically significant with a p value of <0.001. Conclusion: Patients with post COVID-19 status and diabetic status with steroid therapy during the treatment of COVID-19 may increase the risk of developingopportunistic infections like mucormycosis. Post COVID-19 related mucormycosis on computed tomography and magnetic resonance imaging
{"title":"RADIOLOGICAL EVALUATION OF SINONASAL, INTRAORBITAL AND INTRACRANIAL EXTENSION OF MUCORMYCOSIS IN POSTCOVID PATIENTS","authors":"T. Kalekar, V. Rangankar, Pooja Karanjule, Radhika K. Jaipuria, Sahil Kathuria, Neeraj Patil, Giri Nk","doi":"10.21776/ub.mnj.2023.009.02.1","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.1","url":null,"abstract":"Background: Mucormycosis is a fatal and progressive condition that affects immunocompromised patients in the post-COVID state. Radiological assessment by computed tomography and magnetic resonance imaging is useful to determine the severity and extent of the disease. Objective: The objective of this research is to evaluate mucormycosis in post-COVID patients using radiological investigations like computed tomography and magnetic resonance imaging and also to study the extent of disease in patients with diabetes and with steroid/ immunosuppressant use. Methods: A prospective observational study was undertaken at Dr. D. Y. Patil Hospital and Medical College, Pimpri Pune from March-June 2021. All patients who presented with mucormycosis were either COVID-19 positive or recovered from COVID-19 infection. Computed tomography and magnetic resonance imaging were performed in these patients. Results: The association between the status of diabetes mellitus and extent of involvement, steroids/immunosuppressant use and extent of involvement was statistically significant with a p value of <0.001. Conclusion: Patients with post COVID-19 status and diabetic status with steroid therapy during the treatment of COVID-19 may increase the risk of developingopportunistic infections like mucormycosis. Post COVID-19 related mucormycosis on computed tomography and magnetic resonance imaging","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115180666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.11
Reihani Reza, L. Amalia, N. L. Dahlan, Cep Juli, H. Goenawan
Background: Cardioembolic stroke is a category of ischemic stroke that manifests more severe, is prone to recurrence, and is related to a higher mortality rate than the other categories of ischemic stroke. Anticoagulant therapy is recommended in cardioembolic stroke, both for primary and secondary prevention. Objective: The objective of this study is to understand the pattern of anticoagulant therapy in cardioembolic stroke patients admitted at Hasan Sadikin General Hospital Bandung. Methods: The methodology of this study uses retrospective descriptive cross-sectional and use data from medical records collected during January 2015 to December 2020 at Neurology Department of Hasan Sadikin General Hospital with total sampling method. The inclusion criteria were cardioembolic stroke patients that received anticoagulant therapy. Anticoagulant therapy was stratified into Warfarin and New Oral Anticoagulants (NOACs) which consist of dabigatran, rivaroxaban, and edoxaban. To assess stroke severity outcome between warfarin and NOACs we use the National Institutes of Health Stroke Scale (NIHSS) Score. Results: From the 162 cardioembolic stroke patients, the most common oral anticoagulant used was warfarin (90.12%), followed by dabigatran (4.94%), rivaroxaban (3.70%), and edoxaban (1.23%). Only 1 (0.62%) patient who experienced complications from anticoagulant therapy, the complication was non-major bleeding and occurred in warfarin users. Both warfarin and NOACs mainly had NIHSS on discharge in a moderate category with the mean of NIHSS 7.615 and 7.276 for warfarin and NOACs respectively. Conclusion: Warfarin is the most common oral anticoagulant used for cardioembolic stroke based on this study. Both warfarin and NOACs groups have similar stroke severity outcomes measured by NIHSS on discharge and NOACs have lower incidence of bleeding compared to warfarin group.
{"title":"PATTERN OF ANTICOAGULANT THERAPY IN CARDIOEMBOLIC STROKE","authors":"Reihani Reza, L. Amalia, N. L. Dahlan, Cep Juli, H. Goenawan","doi":"10.21776/ub.mnj.2023.009.02.11","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.11","url":null,"abstract":"Background: Cardioembolic stroke is a category of ischemic stroke that manifests more severe, is prone to recurrence, and is related to a higher mortality rate than the other categories of ischemic stroke. Anticoagulant therapy is recommended in cardioembolic stroke, both for primary and secondary prevention. Objective: The objective of this study is to understand the pattern of anticoagulant therapy in cardioembolic stroke patients admitted at Hasan Sadikin General Hospital Bandung. Methods: The methodology of this study uses retrospective descriptive cross-sectional and use data from medical records collected during January 2015 to December 2020 at Neurology Department of Hasan Sadikin General Hospital with total sampling method. The inclusion criteria were cardioembolic stroke patients that received anticoagulant therapy. Anticoagulant therapy was stratified into Warfarin and New Oral Anticoagulants (NOACs) which consist of dabigatran, rivaroxaban, and edoxaban. To assess stroke severity outcome between warfarin and NOACs we use the National Institutes of Health Stroke Scale (NIHSS) Score. Results: From the 162 cardioembolic stroke patients, the most common oral anticoagulant used was warfarin (90.12%), followed by dabigatran (4.94%), rivaroxaban (3.70%), and edoxaban (1.23%). Only 1 (0.62%) patient who experienced complications from anticoagulant therapy, the complication was non-major bleeding and occurred in warfarin users. Both warfarin and NOACs mainly had NIHSS on discharge in a moderate category with the mean of NIHSS 7.615 and 7.276 for warfarin and NOACs respectively. Conclusion: Warfarin is the most common oral anticoagulant used for cardioembolic stroke based on this study. Both warfarin and NOACs groups have similar stroke severity outcomes measured by NIHSS on discharge and NOACs have lower incidence of bleeding compared to warfarin group.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121736669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.6
Herpan Syafii Harahap, Y. Indrayana
Background: Cognitive impairment in the elderly population is commonly associated with age-associated neurodegenerative processes in the brain. The integrity of the cognitive reserve status may be an important factor that can compensate this age-associated neurodegenerative processes. Objective: To investigate the predictor role of poor cognitive reserve status on memory impairment among elderly subpopulation in Mataram, West Nusa Tenggara. Methods: This cross-sectional study involved elderly subjects recruited at Panti Jompo Tresna Werdha Puspa Karma. Data collected included age, gender, hypertension, diabetes, cognitive reserve status (years of education, leisure activity, occupation, and exercise), and memory status. Memory status obtained based on scores of 3 neuropsychological tests (wordlist memory task, recall, and recognition tests). Subjects with normal memory status had normal scores on at least 2 of the 3 neuropsychological tests. Multivariate regression analysis was performed to examine the role of cognitive reserve as a predictor of memory impairment in subjects. Results: In Model 1 of multivariate regression analysis, the main predictors for memory impairment in elderly subjects are shorter years of education (odds ratio: 13.1; 95% confidence interval: 1.8 – 95.0) and absence of leisure activity (odds ratio: 5.9; 1.2 – 28.8). In model 2, the main predictors for memory impairment are consistently shorter years of education (OR: 11.0; 95% CI: 1.4 – 84.0) and absence of leisure activity (OR: 5.3; 95% CI: 1.0 – 27.7). Conclusion: Shorter years of education and the absence of leisure activity were predictors for memory impairment in the subpopulation of the elderly in Mataram, West Nusa Tenggara.
{"title":"POOR COGNITIVE RESERVE STATUS AS PREDICTORS OF MEMORY IMPAIRMENT AMONG ELDERLY","authors":"Herpan Syafii Harahap, Y. Indrayana","doi":"10.21776/ub.mnj.2023.009.02.6","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.6","url":null,"abstract":"Background: Cognitive impairment in the elderly population is commonly associated with age-associated neurodegenerative processes in the brain. The integrity of the cognitive reserve status may be an important factor that can compensate this age-associated neurodegenerative processes. Objective: To investigate the predictor role of poor cognitive reserve status on memory impairment among elderly subpopulation in Mataram, West Nusa Tenggara. Methods: This cross-sectional study involved elderly subjects recruited at Panti Jompo Tresna Werdha Puspa Karma. Data collected included age, gender, hypertension, diabetes, cognitive reserve status (years of education, leisure activity, occupation, and exercise), and memory status. Memory status obtained based on scores of 3 neuropsychological tests (wordlist memory task, recall, and recognition tests). Subjects with normal memory status had normal scores on at least 2 of the 3 neuropsychological tests. Multivariate regression analysis was performed to examine the role of cognitive reserve as a predictor of memory impairment in subjects. Results: In Model 1 of multivariate regression analysis, the main predictors for memory impairment in elderly subjects are shorter years of education (odds ratio: 13.1; 95% confidence interval: 1.8 – 95.0) and absence of leisure activity (odds ratio: 5.9; 1.2 – 28.8). In model 2, the main predictors for memory impairment are consistently shorter years of education (OR: 11.0; 95% CI: 1.4 – 84.0) and absence of leisure activity (OR: 5.3; 95% CI: 1.0 – 27.7). Conclusion: Shorter years of education and the absence of leisure activity were predictors for memory impairment in the subpopulation of the elderly in Mataram, West Nusa Tenggara.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"142 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114448790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.3
A. Yabalak, Petek Sarli, Mustafa YILMAZ, Hilmiye Tokmak, M. Ogun
Background: Lacunar ischemic infarcts are small-sized infarcts that develop as a result of occlusion of perforating arteries. Although its pathophysiology differs from other stroke types, there is no separate treatment option from non-cardioembolic strokes. Early neurological worsening in lacunar strokes is a common condition reported up to 41%. There is no effective treatment method to prevent or correct progression. Tirofiban is a reversible receptor antagonist of glycoprotein IIb/IIIa. There are cohort studies with small number of cases related to its use in ischemic stroke. We wanted to evaluate its effectiveness on the progression of lacunar stroke because it is a powerful antiplatelet agent. Objective: Tirofiban is a reversible receptor antagonist of glycoprotein IIb/IIIa. There are cohort studies with small number of cases related to its use in ischemic stroke. We wanted to evaluate its effectiveness on the progression of lacunar stroke because it is a powerful antiplatelet agent. Methods: The data of patients who were followed up in our clinic with the diagnosis of lacunar stroke between August 2020 and May 2022 and who received tirofiban treatment were evaluated retrospectively. Patients' ages, infarct localizations, NIHSS scores at admission, at the beginning and end of tirofiban treatment, and 3rd month mRS scores were recorded. Results: Fifteen patients, 11 male and 4 female, were included in the study. The mean age of the patients was 68.73±9.58 (range, 51-85). Tirofiban was started proactively in 2 patients, after progression in 13 patients. The NIHSS scores were 7.20±2.65 at the start of the infusion, and 4.80±3.93 after the infusion, and the decrease was statistically significant (P=0.010). Conclusion: These findings suggest that intravenous tirofiban therapy is a safe and effective treatment option to stop symptomatic fluctuations and shorten the duration of deficit in patients with progressive lacunar stroke.
{"title":"EFFICACY OF INTRAVENOUS TIROFIBAN THERAPY IN LACUNAR STROKE PATIENTS","authors":"A. Yabalak, Petek Sarli, Mustafa YILMAZ, Hilmiye Tokmak, M. Ogun","doi":"10.21776/ub.mnj.2023.009.02.3","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.3","url":null,"abstract":"Background: Lacunar ischemic infarcts are small-sized infarcts that develop as a result of occlusion of perforating arteries. Although its pathophysiology differs from other stroke types, there is no separate treatment option from non-cardioembolic strokes. Early neurological worsening in lacunar strokes is a common condition reported up to 41%. There is no effective treatment method to prevent or correct progression. Tirofiban is a reversible receptor antagonist of glycoprotein IIb/IIIa. There are cohort studies with small number of cases related to its use in ischemic stroke. We wanted to evaluate its effectiveness on the progression of lacunar stroke because it is a powerful antiplatelet agent. Objective: Tirofiban is a reversible receptor antagonist of glycoprotein IIb/IIIa. There are cohort studies with small number of cases related to its use in ischemic stroke. We wanted to evaluate its effectiveness on the progression of lacunar stroke because it is a powerful antiplatelet agent. Methods: The data of patients who were followed up in our clinic with the diagnosis of lacunar stroke between August 2020 and May 2022 and who received tirofiban treatment were evaluated retrospectively. Patients' ages, infarct localizations, NIHSS scores at admission, at the beginning and end of tirofiban treatment, and 3rd month mRS scores were recorded. Results: Fifteen patients, 11 male and 4 female, were included in the study. The mean age of the patients was 68.73±9.58 (range, 51-85). Tirofiban was started proactively in 2 patients, after progression in 13 patients. The NIHSS scores were 7.20±2.65 at the start of the infusion, and 4.80±3.93 after the infusion, and the decrease was statistically significant (P=0.010). Conclusion: These findings suggest that intravenous tirofiban therapy is a safe and effective treatment option to stop symptomatic fluctuations and shorten the duration of deficit in patients with progressive lacunar stroke.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"93 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122214602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.10
N. Raisa, A. F. Insanitaqwa, Masruroh Rahayu
Background: Parkinson's disease still requires special attention considering that this condition is a progressive disease that leads to a decrease in the quality of life and life expectancy of the patient. Objective: This study aims to determine the level of understanding of general practitioners regarding Parkinson's disease and other movement disorders. Methods: We conducted a one group pretest posttest design study on 124 general practitioners who attended the World Parkinson Day Seminar. . The research instrument was a questionnaire with 20 questions, filled in by the participants independently. Knowledge level categories are good (76-100), sufficient (56-75), and poor (<55). Results: The result of the study showed that 18% [22 respondents] had a good level of understanding, 58% [72 respondents] had sufficient knowledge, and 24% [30 respondents] had poor knowledge in terms of the pretest score. There was an increase in the average score (from 65.93 to 78.9) of the respondents after attending the seminar (p<0.05). Conclusion: This study identified that there was a significantly increased level of knowledge of Parkinson's disease symptoms after the seminar for general practitioners in Indonesia.
{"title":"THE DEPICTION OF GENERAL PHYSICIAN’S KNOWLEDGE LEVEL OF PARKINSON’S DISEASE IN INDONESIA","authors":"N. Raisa, A. F. Insanitaqwa, Masruroh Rahayu","doi":"10.21776/ub.mnj.2023.009.02.10","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.10","url":null,"abstract":"Background: Parkinson's disease still requires special attention considering that this condition is a progressive disease that leads to a decrease in the quality of life and life expectancy of the patient. Objective: This study aims to determine the level of understanding of general practitioners regarding Parkinson's disease and other movement disorders. Methods: We conducted a one group pretest posttest design study on 124 general practitioners who attended the World Parkinson Day Seminar. . The research instrument was a questionnaire with 20 questions, filled in by the participants independently. Knowledge level categories are good (76-100), sufficient (56-75), and poor (<55). Results: The result of the study showed that 18% [22 respondents] had a good level of understanding, 58% [72 respondents] had sufficient knowledge, and 24% [30 respondents] had poor knowledge in terms of the pretest score. There was an increase in the average score (from 65.93 to 78.9) of the respondents after attending the seminar (p<0.05). Conclusion: This study identified that there was a significantly increased level of knowledge of Parkinson's disease symptoms after the seminar for general practitioners in Indonesia.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124154612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-01DOI: 10.21776/ub.mnj.2023.009.02.18
Raden Andi Ario Tedjo, Hillary Hillary, Vivienne Tjung, S. E. Putra, Muhammad Hafizhan
Case Report: A 50-year-old man was referred to Dr. Moewardi General Hospital with history of right chest pain that radiate to the right back and hand for 2 months. His complaint did not improve with medication and physical therapy. On physical examination we observed multiple nodules on the right axilla, scapula, and colli region. Neurological examination revealed right sided partial ptosis, anisocoria, ipsilateral weakness, and ipsilateral allodynia, and anhidrosis T1 dermatome. CT-scan showed a right lung mass in the superior lobe of the apical segment. The diagnosis of Horner syndrome is then established caused by multiple lymphadenopathies. His symptoms then relieved after lymphadenectomy. Conclusion: Horner syndrome, characterized by ipsilateral pupillary anisocoria, ptosis and anhidrosis, is one of the complications of Pancoast tumor invasion to the sympathetic nervous system in the C8, T1, and T2 nerve territory.
{"title":"PANCOAST TUMOR PRESENTING WITH HORNER SYNDROME: A CASE REPORT","authors":"Raden Andi Ario Tedjo, Hillary Hillary, Vivienne Tjung, S. E. Putra, Muhammad Hafizhan","doi":"10.21776/ub.mnj.2023.009.02.18","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.02.18","url":null,"abstract":"Case Report: A 50-year-old man was referred to Dr. Moewardi General Hospital with history of right chest pain that radiate to the right back and hand for 2 months. His complaint did not improve with medication and physical therapy. On physical examination we observed multiple nodules on the right axilla, scapula, and colli region. Neurological examination revealed right sided partial ptosis, anisocoria, ipsilateral weakness, and ipsilateral allodynia, and anhidrosis T1 dermatome. CT-scan showed a right lung mass in the superior lobe of the apical segment. The diagnosis of Horner syndrome is then established caused by multiple lymphadenopathies. His symptoms then relieved after lymphadenectomy. Conclusion: Horner syndrome, characterized by ipsilateral pupillary anisocoria, ptosis and anhidrosis, is one of the complications of Pancoast tumor invasion to the sympathetic nervous system in the C8, T1, and T2 nerve territory.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126889543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-02DOI: 10.21776/ub.mnj.2023.009.01.17
Dessika Rahmawati, B. Munir, N. Setijowati, Catur Ari Setianto, Ria Damayanti, Bimo Mubyarto
Background: Meningioma is one of the most commonly reported primary central nervous system (CNS) tumors, originating from arachnoid meningeal cells and including intracranial extra-axial neoplasms. Although meningioma is considerably benign, the patient conditions are reported to be diverse resulting in severe and life-threatening neurological deficits. Hence the assessment regarding functional status is deemed pivotal to provide a prognostic perspective as patient presentation exhibits disability due to lesions and other factors. Objective: This research aims to analyze factors affecting the functional status of patients with meningioma in Dr. Saiful Anwar General Hospital Malang. Methods: An analytic retrospective study was conducted with cross-sectional study involving 62 samples from patients visits with meningioma brain tumor in RSUD dr. Saiful Anwar General Hospital Malang from January 2017 to December 2020. The data was selected through non-probability sampling, generating sampling type from brain tumor register data Neurology. Results: Data obtained from 62 meningioma patients in RSUD dr. Saiful Anwar General Hospital Malang met the inclusion criteria from January 2017 to December 2020, based on demographic characteristics such as age of <50 in 38 patients (61.3%) and age of >50 in 24 patients (38.7%). Clinically, it was found that 58 patients (93.5%) experienced headache, 28 patients (45.2%) experienced decreasing consciousness, 15 patients (24.2%) had hemiplegia, and 17 patients (27.4%) had hemiparesis, 17 people had hemiparesis. 17 patients (27.4%) experienced visual disturbances, and 24 patients (38.7%) are with seizures. Based on the radiology screening sites, 46 patients (74.2%) were screened in Convexity sphere, 9 patients (14.5%) were screened at Cranial base, 3 patients (4.8%) were screened at Parasagittal, and 4 patients (6.5%) were screene at Falx, from which the 41 patients (66.1%) exhibited herniation. Based on comorbidities, 12 patients (19.4%) had sepsis, and 1 patient (1.6%) had pneumonia. From the analysis test results, it was found that decreasing consciousness (GCS) was significantly correlated with functional status, referred to Karnofsky Performance Scale of <70 (p: 0.013, p <0.05). Seizures were reported to be correlated significantly with functional status, referred to Karnofsky Performance Scale of > 70 (p: 0.015, p<0.05). Tumor location was significantly correlated with functional status, reffered to Karnofsky Performance Scale of > 70 (p: 0.027, p<0.05). Conclusion: The factors affecting the functional status based on the Karnofsky Performance Scale (KPS) of a patient with meningioma at Dr. Saiful Anwar General Hospital Malang included: decreasing consciousness (GCS), and seizures, and tumor location.
{"title":"FACTORS AFFECTING THE FUNCTIONAL STATUS OF PATIENT WITH MENINGIOMA IN DR. SAIFUL ANWAR GENERAL HOSPITAL MALANG","authors":"Dessika Rahmawati, B. Munir, N. Setijowati, Catur Ari Setianto, Ria Damayanti, Bimo Mubyarto","doi":"10.21776/ub.mnj.2023.009.01.17","DOIUrl":"https://doi.org/10.21776/ub.mnj.2023.009.01.17","url":null,"abstract":"Background: Meningioma is one of the most commonly reported primary central nervous system (CNS) tumors, originating from arachnoid meningeal cells and including intracranial extra-axial neoplasms. Although meningioma is considerably benign, the patient conditions are reported to be diverse resulting in severe and life-threatening neurological deficits. Hence the assessment regarding functional status is deemed pivotal to provide a prognostic perspective as patient presentation exhibits disability due to lesions and other factors. Objective: This research aims to analyze factors affecting the functional status of patients with meningioma in Dr. Saiful Anwar General Hospital Malang. Methods: An analytic retrospective study was conducted with cross-sectional study involving 62 samples from patients visits with meningioma brain tumor in RSUD dr. Saiful Anwar General Hospital Malang from January 2017 to December 2020. The data was selected through non-probability sampling, generating sampling type from brain tumor register data Neurology. Results: Data obtained from 62 meningioma patients in RSUD dr. Saiful Anwar General Hospital Malang met the inclusion criteria from January 2017 to December 2020, based on demographic characteristics such as age of <50 in 38 patients (61.3%) and age of >50 in 24 patients (38.7%). Clinically, it was found that 58 patients (93.5%) experienced headache, 28 patients (45.2%) experienced decreasing consciousness, 15 patients (24.2%) had hemiplegia, and 17 patients (27.4%) had hemiparesis, 17 people had hemiparesis. 17 patients (27.4%) experienced visual disturbances, and 24 patients (38.7%) are with seizures. Based on the radiology screening sites, 46 patients (74.2%) were screened in Convexity sphere, 9 patients (14.5%) were screened at Cranial base, 3 patients (4.8%) were screened at Parasagittal, and 4 patients (6.5%) were screene at Falx, from which the 41 patients (66.1%) exhibited herniation. Based on comorbidities, 12 patients (19.4%) had sepsis, and 1 patient (1.6%) had pneumonia. From the analysis test results, it was found that decreasing consciousness (GCS) was significantly correlated with functional status, referred to Karnofsky Performance Scale of <70 (p: 0.013, p <0.05). Seizures were reported to be correlated significantly with functional status, referred to Karnofsky Performance Scale of > 70 (p: 0.015, p<0.05). Tumor location was significantly correlated with functional status, reffered to Karnofsky Performance Scale of > 70 (p: 0.027, p<0.05). Conclusion: The factors affecting the functional status based on the Karnofsky Performance Scale (KPS) of a patient with meningioma at Dr. Saiful Anwar General Hospital Malang included: decreasing consciousness (GCS), and seizures, and tumor location.","PeriodicalId":247353,"journal":{"name":"MNJ (Malang Neurology Journal)","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128320593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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