A. S. M. Saikat, Apurbo Kumar Paul, Dipta Dey, R. Das, Madhab C. Das
: Nipah henipavirus is an emerging RNA virus that poses a danger to world safety due to its high fatality rate. The Nipah virus has caused several illness epidemics in South and Southeast Asia. The matrix protein of Nipah henipavirus plays a crucial function in linking the viral envelope to the virus core. Connecting the viral envelope to the virus core is critical for virus assembly. Through analyses of structural and functional protein explanations, bioinformatics tools can aid in our comprehension of the protein. This study intends to provide structural and functional annotations to proteins. Using in silico approaches, the analysis also assigns the protein’s physicochemical properties, three-dimensional structure, and functional annotation. The in silico research validated the protein’s hydrophilic nature and alpha ( α ) helix-dominated secondary structure. The protein’s tertiary structure model is generally consistent based on various quality evaluation approaches. The functional explanation claimed that the protein is a structural protein that connects the viral envelope to the virus core, a protein that is necessary for virus assembly. This study reveals the importance of the matrix protein as a functional protein needed by Nipah henipavirus .
{"title":"In-Silico Approaches for Molecular Characterization and Structure-Based Functional Annotation of the Matrix Protein from Nipah henipavirus ","authors":"A. S. M. Saikat, Apurbo Kumar Paul, Dipta Dey, R. Das, Madhab C. Das","doi":"10.3390/ecsoc-26-13522","DOIUrl":"https://doi.org/10.3390/ecsoc-26-13522","url":null,"abstract":": Nipah henipavirus is an emerging RNA virus that poses a danger to world safety due to its high fatality rate. The Nipah virus has caused several illness epidemics in South and Southeast Asia. The matrix protein of Nipah henipavirus plays a crucial function in linking the viral envelope to the virus core. Connecting the viral envelope to the virus core is critical for virus assembly. Through analyses of structural and functional protein explanations, bioinformatics tools can aid in our comprehension of the protein. This study intends to provide structural and functional annotations to proteins. Using in silico approaches, the analysis also assigns the protein’s physicochemical properties, three-dimensional structure, and functional annotation. The in silico research validated the protein’s hydrophilic nature and alpha ( α ) helix-dominated secondary structure. The protein’s tertiary structure model is generally consistent based on various quality evaluation approaches. The functional explanation claimed that the protein is a structural protein that connects the viral envelope to the virus core, a protein that is necessary for virus assembly. This study reveals the importance of the matrix protein as a functional protein needed by Nipah henipavirus .","PeriodicalId":255032,"journal":{"name":"The 26th International Electronic Conference on Synthetic Organic Chemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129836448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leandro G. Gutierrez, Ana P. Reinick, Carla M. Ormachea, Vanina A. Guntero, C. Ferretti
: The aim of this study was to investigate the antioxidant properties in vitro of three different vanillic dimmers (Compounds 1a–c ). They were synthesized through an oxidative coupling strategy in good yields. The targeted compounds were found to be highly active for the total antioxidant assay, as well as for the lipid peroxidation test. All investigated compounds exhibited superior or comparable antioxidant capacity in comparison to precursor vanillin, proving that oxidative coupling is a great strategy to increase the antioxidant behavior of vanillin derivatives.
{"title":"Use of Oxidative Coupling Strategy as a Means to Increase In Vitro Antioxidant Activity of Vanillin Derivatives","authors":"Leandro G. Gutierrez, Ana P. Reinick, Carla M. Ormachea, Vanina A. Guntero, C. Ferretti","doi":"10.3390/ecsoc-26-13553","DOIUrl":"https://doi.org/10.3390/ecsoc-26-13553","url":null,"abstract":": The aim of this study was to investigate the antioxidant properties in vitro of three different vanillic dimmers (Compounds 1a–c ). They were synthesized through an oxidative coupling strategy in good yields. The targeted compounds were found to be highly active for the total antioxidant assay, as well as for the lipid peroxidation test. All investigated compounds exhibited superior or comparable antioxidant capacity in comparison to precursor vanillin, proving that oxidative coupling is a great strategy to increase the antioxidant behavior of vanillin derivatives.","PeriodicalId":255032,"journal":{"name":"The 26th International Electronic Conference on Synthetic Organic Chemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131080312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Makarov, L. Dzhemileva, E. K. Makarova, U. Dzhemilev
: This report presents data on our studies on the preparation of the precursor lembehyne A and the complete stereoselective synthesis of natural lembehynes B and C, which have cytotoxic and neuritogenic activity. All methods and approaches to the synthesis of the above-mentioned lembehynes presented in this report are based on the use of the catalytic cross-cyclomagnesiation of 1,2-dienes (Dzhemilev reaction) at the key stage of the synthesis.
{"title":"Development of New Effective Methods for the Synthesis of Lembehynes A–C Exhibiting Cytotoxic and Neuritogenic Activity","authors":"A. Makarov, L. Dzhemileva, E. K. Makarova, U. Dzhemilev","doi":"10.3390/ecsoc-26-13524","DOIUrl":"https://doi.org/10.3390/ecsoc-26-13524","url":null,"abstract":": This report presents data on our studies on the preparation of the precursor lembehyne A and the complete stereoselective synthesis of natural lembehynes B and C, which have cytotoxic and neuritogenic activity. All methods and approaches to the synthesis of the above-mentioned lembehynes presented in this report are based on the use of the catalytic cross-cyclomagnesiation of 1,2-dienes (Dzhemilev reaction) at the key stage of the synthesis.","PeriodicalId":255032,"journal":{"name":"The 26th International Electronic Conference on Synthetic Organic Chemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133465741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Goněc, Lucia Vráblová, Dominika Pindjaková, Tomas Strharsky, M. Oravec, J. Jampílek
: A series of twenty-two monosubstituted N -aryl-4-hydroxyquinoline-3-carboxanilides designed as dual anti-invasive agents was prepared and characterized. Lipophilicity significantly affects biological activities of compounds and ADME properties; therefore, the lipo-hydrophilic properties of these 4-hydroxyquinoline-3-carboxanilides were investigated. All the derivatives were analyzed using reversed-phase high-performance liquid chromatography. The procedure was carried out under isocratic conditions with methanol as the organic modifier in the mobile phase using an end-capped non-polar C18 stationary reversed-phase column. In this study, correlations between the logarithm of the capacity factor k and log P /Clog P values calculated using various methods are discussed, as well as the relationships between lipophilicity and chemical structure of the studied compounds.
制备了22种单取代N -芳基-4-羟基喹啉-3-羧基苯胺类双抗侵入剂，并对其进行了表征。亲脂性显著影响化合物的生物活性和ADME性能;因此，对这些4-羟基喹啉-3-羧基苯胺类化合物的亲脂性进行了研究。所有衍生物均采用反相高效液相色谱分析。在等温条件下，以甲醇为有机改性剂，在流动相中使用端盖非极性C18固定反相柱。在本研究中，讨论了容量因子k的对数与使用各种方法计算的log P /Clog P值之间的相关性，以及所研究化合物的亲脂性与化学结构之间的关系。
{"title":"Preparation and Hydro-Lipophilic Properties of Monosubstituted N-Aryl-4-hydroxyquinoline-3-carboxanilides","authors":"T. Goněc, Lucia Vráblová, Dominika Pindjaková, Tomas Strharsky, M. Oravec, J. Jampílek","doi":"10.3390/ecsoc-26-13548","DOIUrl":"https://doi.org/10.3390/ecsoc-26-13548","url":null,"abstract":": A series of twenty-two monosubstituted N -aryl-4-hydroxyquinoline-3-carboxanilides designed as dual anti-invasive agents was prepared and characterized. Lipophilicity significantly affects biological activities of compounds and ADME properties; therefore, the lipo-hydrophilic properties of these 4-hydroxyquinoline-3-carboxanilides were investigated. All the derivatives were analyzed using reversed-phase high-performance liquid chromatography. The procedure was carried out under isocratic conditions with methanol as the organic modifier in the mobile phase using an end-capped non-polar C18 stationary reversed-phase column. In this study, correlations between the logarithm of the capacity factor k and log P /Clog P values calculated using various methods are discussed, as well as the relationships between lipophilicity and chemical structure of the studied compounds.","PeriodicalId":255032,"journal":{"name":"The 26th International Electronic Conference on Synthetic Organic Chemistry","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114972411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tomás Cavaco, Diogo Gonçalves, A. Pombo, C. Moiteiro, M. Inácio, Jorge M. S. Faria
: The pinewood nematode (PWN), Bursaphelenchus xylophilus , the causal agent of pine-wilt disease (PWD), is a threat to Pinus forests in Asia and Europe. Bursaphelenchus mucronatus and B. fraudulentus are closely related non-pathogenic pine-wood nematodes. In the present work, four medium-chain aliphatic alcohols (C10 to C13) were evaluated in direct-contact bioassays against B. xylophilus , B. mucronatus and B. fraudulentus . The compounds showed high nematicidal activity against the species tested. The lowest values for half-maximal effective concentrations (EC 50 ) were determined in B. xylophilus and B. fraudulentus , suggesting a higher sensibility to these compounds. Further bioassays will include compounds with different chain lengths and functional groups to explore the diversity in the activity of oxygen-containing aliphatic compounds for a more targeted sustainable-control strategy for the PWN.
{"title":"Nematicidal Activity of Oxygen-Containing Aliphatic Compounds on Bursaphelenchus xylophilus, B. mucronatus and B. fraudulentus ","authors":"Tomás Cavaco, Diogo Gonçalves, A. Pombo, C. Moiteiro, M. Inácio, Jorge M. S. Faria","doi":"10.3390/ecsoc-26-13536","DOIUrl":"https://doi.org/10.3390/ecsoc-26-13536","url":null,"abstract":": The pinewood nematode (PWN), Bursaphelenchus xylophilus , the causal agent of pine-wilt disease (PWD), is a threat to Pinus forests in Asia and Europe. Bursaphelenchus mucronatus and B. fraudulentus are closely related non-pathogenic pine-wood nematodes. In the present work, four medium-chain aliphatic alcohols (C10 to C13) were evaluated in direct-contact bioassays against B. xylophilus , B. mucronatus and B. fraudulentus . The compounds showed high nematicidal activity against the species tested. The lowest values for half-maximal effective concentrations (EC 50 ) were determined in B. xylophilus and B. fraudulentus , suggesting a higher sensibility to these compounds. Further bioassays will include compounds with different chain lengths and functional groups to explore the diversity in the activity of oxygen-containing aliphatic compounds for a more targeted sustainable-control strategy for the PWN.","PeriodicalId":255032,"journal":{"name":"The 26th International Electronic Conference on Synthetic Organic Chemistry","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114140425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Salim Ullah, Zahid Hussain, Li Wang, Ismat Ullah, Shahnawaz Mehmood, Bingqing Luo, Yuehu Zhang, M. W. Ghani, R. Pei, Jine Wang
: Cyclodextrins (CDs) are macrocyclic oligosaccharides, containing between six and eight alpha(1 → 4)-linked glucopyranoses. CDs have a hydrophobic cone-shaped internal cavity and a hydrophilic exterior surface. They form non-covalent inclusion complexes (ICs) with various drugs by trapping the full or partial inclusions in their cavity. Supramolecular ICs have gained attention in engineering entrapped drug performance field due to their potential to protect and modify the physicochemical properties of entrapped lipophilic and volatile drugs. However, the poor structural and mechanical properties of pure CD-ICs could restrict their application and the need for a suitable carrier system. Electrospun nanofibers have been the center of attention for biomedical applications due to their tunable physicochemical properties. Recent studies have highlighted that the entrapment of drug/CD-based ICs into nanofibers is an active research area since it facilitates high encapsulation, it modulates the release profile of the guest, integrates multi-type drugs, and leads to a synergistic effect. This mini-review first summarizes the potential benefits and shortcomings of drug/CD-ICs and nanofibers, and then, we discuss the advancements in the fabrication and characteristics of CD-ICs embedded nanofibers, along with some practical suggestions for potential biomedical applications.
环糊精(cd)是一种大环低聚糖，含有6 - 8个α(1→4)-连接的葡萄糖醛酸。CDs具有疏水的锥形内腔和亲水的外表面。它们通过将全部或部分包涵体捕获在其腔内，与各种药物形成非共价包涵体(ICs)。超分子集成电路由于具有保护和改变包埋的亲脂性和挥发性药物理化性质的潜力，在工程包埋药物性能领域受到了广泛关注。然而，纯CD-ICs较差的结构和力学性能限制了它们的应用和对合适载流子系统的需求。电纺丝纳米纤维由于其可调的物理化学性质而成为生物医学应用的关注焦点。最近的研究表明，基于药物/ cd的集成电路包埋在纳米纤维中是一个活跃的研究领域，因为它有助于高封装，调节客体的释放特征，整合多种类型的药物，并导致协同效应。本文首先总结了药物/ cd - ic和纳米纤维的潜在优点和缺点，然后讨论了嵌入cd - ic的纳米纤维的制备和特性的进展，并对潜在的生物医学应用提出了一些实际建议。
{"title":"Cyclodextrin-Based Host–Guest Supramolecular Nanofibrous Composite for Biomedical Applications","authors":"Salim Ullah, Zahid Hussain, Li Wang, Ismat Ullah, Shahnawaz Mehmood, Bingqing Luo, Yuehu Zhang, M. W. Ghani, R. Pei, Jine Wang","doi":"10.3390/ecsoc-26-13523","DOIUrl":"https://doi.org/10.3390/ecsoc-26-13523","url":null,"abstract":": Cyclodextrins (CDs) are macrocyclic oligosaccharides, containing between six and eight alpha(1 → 4)-linked glucopyranoses. CDs have a hydrophobic cone-shaped internal cavity and a hydrophilic exterior surface. They form non-covalent inclusion complexes (ICs) with various drugs by trapping the full or partial inclusions in their cavity. Supramolecular ICs have gained attention in engineering entrapped drug performance field due to their potential to protect and modify the physicochemical properties of entrapped lipophilic and volatile drugs. However, the poor structural and mechanical properties of pure CD-ICs could restrict their application and the need for a suitable carrier system. Electrospun nanofibers have been the center of attention for biomedical applications due to their tunable physicochemical properties. Recent studies have highlighted that the entrapment of drug/CD-based ICs into nanofibers is an active research area since it facilitates high encapsulation, it modulates the release profile of the guest, integrates multi-type drugs, and leads to a synergistic effect. This mini-review first summarizes the potential benefits and shortcomings of drug/CD-ICs and nanofibers, and then, we discuss the advancements in the fabrication and characteristics of CD-ICs embedded nanofibers, along with some practical suggestions for potential biomedical applications.","PeriodicalId":255032,"journal":{"name":"The 26th International Electronic Conference on Synthetic Organic Chemistry","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114222048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victor A. Lucas-Rosales, M. García-Revilla, J. Jiménez‐Halla
: The Thorpe reaction is described as a self-condensation of nitriles in the presence of a basic catalyst producing β -enaminonitriles. We performed theoretical calculations within the Density Functional Theory (DFT) framework at the ω B97XD/def2-svpd level to explore different mechanistic proposals when propionitrile is used as a reagent and sodium ethoxide (EtONa) as a catalyst. Furthermore, the influence of different solvents, such as ethanol (EtOH), tetrahydrofuran (THF), 1,2-dimethoxyethane (DME), and propionitrile (EtCN), was assessed. Finally, we also evaluated the effect of the fluorine group (-F), compared to the methyl group (-CH 3 ), substituted in the α position of acetonitrile (MeCN). Our theoretical findings agree with different experimental reports on the Thorpe reaction.
{"title":"Computational Revision of the Mechanism of the Thorpe Reaction","authors":"Victor A. Lucas-Rosales, M. García-Revilla, J. Jiménez‐Halla","doi":"10.3390/ecsoc-26-13550","DOIUrl":"https://doi.org/10.3390/ecsoc-26-13550","url":null,"abstract":": The Thorpe reaction is described as a self-condensation of nitriles in the presence of a basic catalyst producing β -enaminonitriles. We performed theoretical calculations within the Density Functional Theory (DFT) framework at the ω B97XD/def2-svpd level to explore different mechanistic proposals when propionitrile is used as a reagent and sodium ethoxide (EtONa) as a catalyst. Furthermore, the influence of different solvents, such as ethanol (EtOH), tetrahydrofuran (THF), 1,2-dimethoxyethane (DME), and propionitrile (EtCN), was assessed. Finally, we also evaluated the effect of the fluorine group (-F), compared to the methyl group (-CH 3 ), substituted in the α position of acetonitrile (MeCN). Our theoretical findings agree with different experimental reports on the Thorpe reaction.","PeriodicalId":255032,"journal":{"name":"The 26th International Electronic Conference on Synthetic Organic Chemistry","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114632724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Lipid-based nanoparticles (LBNs) are a new type of nanoparticulate drug-delivery system, which have gradually demonstrated broad prospects in pulmonary drug-delivery systems. However, the main disadvantage of these LBNs for inhalable drugs with limited lipophilicity is their low encapsulation capacity. Herein, this study anticipates establishing a technology platform to improve the loading capacity of low-lipophilicity drugs in LBNs for the therapy of lung diseases. A proof-of-concept study was carried out using Beclomethasone dipropionate (BDP) as a model drug. BDP was conjugated with stearic acid (SA), a kind of the lipid matrix for LBN. The conjugate was characterized and the interactions between the conjugate and SA were investigated via molecular dynamics simulation. It is expected that the drug-loading capacity of weak-lipophilic drugs in LBN can be increased by establishing the technology platform, and the application of LBNs in pulmonary delivery can be broadened.
{"title":"Construction of Lipid–Drug Conjugates for Beclomethasone Dipropionate","authors":"S. Dang, Zhengwei Huang, Xingang Pan","doi":"10.3390/ecsoc-26-13528","DOIUrl":"https://doi.org/10.3390/ecsoc-26-13528","url":null,"abstract":": Lipid-based nanoparticles (LBNs) are a new type of nanoparticulate drug-delivery system, which have gradually demonstrated broad prospects in pulmonary drug-delivery systems. However, the main disadvantage of these LBNs for inhalable drugs with limited lipophilicity is their low encapsulation capacity. Herein, this study anticipates establishing a technology platform to improve the loading capacity of low-lipophilicity drugs in LBNs for the therapy of lung diseases. A proof-of-concept study was carried out using Beclomethasone dipropionate (BDP) as a model drug. BDP was conjugated with stearic acid (SA), a kind of the lipid matrix for LBN. The conjugate was characterized and the interactions between the conjugate and SA were investigated via molecular dynamics simulation. It is expected that the drug-loading capacity of weak-lipophilic drugs in LBN can be increased by establishing the technology platform, and the application of LBNs in pulmonary delivery can be broadened.","PeriodicalId":255032,"journal":{"name":"The 26th International Electronic Conference on Synthetic Organic Chemistry","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126784991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriela Servín-García, L. Chacón-García, Joaquín González-Marrero, Mariana Macías-Alonso, Mario A. Gómez-Hurtado, Gabriela Rodríguez-García, R. D. del Río, C. Cortés-García
{"title":"Semisynthesis of 6β-Acetoxyvouacapane Derivatives via the Ugi-Azide Multicomponent Reaction","authors":"Gabriela Servín-García, L. Chacón-García, Joaquín González-Marrero, Mariana Macías-Alonso, Mario A. Gómez-Hurtado, Gabriela Rodríguez-García, R. D. del Río, C. Cortés-García","doi":"10.3390/ecsoc-26-13552","DOIUrl":"https://doi.org/10.3390/ecsoc-26-13552","url":null,"abstract":"","PeriodicalId":255032,"journal":{"name":"The 26th International Electronic Conference on Synthetic Organic Chemistry","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132283780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Milena M. Jovanović, Katarina Virijević, Dejan Arsenijević, Katarina Pecić, D. Šeklić
: The deregulation of a Wnt/ β -catenin signal pathway is common in colorectal cancer, while β -catenin, its crucial component, is the target for the development of many anticancer therapies. Here, we showed that royal jelly, as a well-known beneficial natural product, can affect β -catenin at both the gene and protein level in HCT-116 colorectal cancer cell line. Our results indicate the effectiveness of royal jelly in targeting crucial markers responsible for the development and progression of cancer. Therefore, royal jelly presents a promising agent for the development of supplementary anticancer therapy.
{"title":"Expression of β-Catenin Marker in Colorectal Cancer Cells after Treatment with Royal Jelly","authors":"Milena M. Jovanović, Katarina Virijević, Dejan Arsenijević, Katarina Pecić, D. Šeklić","doi":"10.3390/ecsoc-26-13531","DOIUrl":"https://doi.org/10.3390/ecsoc-26-13531","url":null,"abstract":": The deregulation of a Wnt/ β -catenin signal pathway is common in colorectal cancer, while β -catenin, its crucial component, is the target for the development of many anticancer therapies. Here, we showed that royal jelly, as a well-known beneficial natural product, can affect β -catenin at both the gene and protein level in HCT-116 colorectal cancer cell line. Our results indicate the effectiveness of royal jelly in targeting crucial markers responsible for the development and progression of cancer. Therefore, royal jelly presents a promising agent for the development of supplementary anticancer therapy.","PeriodicalId":255032,"journal":{"name":"The 26th International Electronic Conference on Synthetic Organic Chemistry","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133006177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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