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Spectrum of paediatric orthopaedic injuries in Patient attending emergency department of Gandaki Medical College of Pokhara, Nepal 尼泊尔博卡拉甘达基医学院急诊科儿童骨科损伤谱
Pub Date : 2018-12-31 DOI: 10.3126/MJPAHS.V1I2.23390
Is Kandel, Karuna Acharya, Sandip Gupta, B. Shrestha
Background: Children are vulnerable to musculoskeletal injuries both at home and on the street for various reasons. Morbidity and disabilities resulting from these, mostly preventable, injuries, make them a burden to their families and society. The role of various factors associated with injuries is often not documented. Methods: This prospective, cross sectional study was done on 80 children aged below 16 years with musculoskeletal trauma, data were collected and analysis was done using Microsoft excel and frequency table. The various modes of injuries, place of injuries, pattern of injuries and regional distribution of injuries were analyzed. Results: One in every four to five patient was a child below 16 years of age. Boys were injured more than girls. Injuries, especially fractures, were most common in the extremities, the upper limb more commonly injured than the lower limb. Most of the injuries occurred at home. The most common mode of injuries was falls that happened while playing both within and outside the home, followed by road traffic accidents. Most injuries occurred during daytime. Conclusions: Many injuries in children were found to be preventable. Small interventions and modification while constructing homes and surroundings can contribute tremendously to injury prevention and control in children. Parental awareness about the various modes of injury, role of supervised playing and their responsibility towards injury prevention can play a key role in reducing the morbidity associated with childhood fractures.
背景:由于各种原因,儿童在家里和街上都容易受到肌肉骨骼损伤。这些大多可预防的伤害造成的发病和残疾使她们成为家庭和社会的负担。与损伤相关的各种因素的作用通常没有记录。方法:对80例16岁以下的肌肉骨骼损伤患儿进行前瞻性横断面研究,采用excel软件和频率表进行数据收集和分析。分析了各种损伤方式、损伤部位、损伤形态及损伤区域分布。结果:每4 - 5例患者中就有1例是16岁以下的儿童。男孩受伤比女孩多。损伤,尤其是骨折,在四肢最常见,上肢比下肢更常见。大多数受伤发生在家中。最常见的受伤方式是在家内外玩耍时摔倒,其次是道路交通事故。大多数受伤发生在白天。结论:许多儿童损伤是可以预防的。在建造房屋和周围环境时,小小的干预和修改可以极大地促进儿童伤害的预防和控制。父母对各种伤害模式的认识,监督玩耍的作用以及他们对伤害预防的责任可以在降低儿童骨折相关发病率方面发挥关键作用。
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引用次数: 1
Decreased fetal movement: Is it an alarm to Obstetrician and Pregnant Lady? 胎动减少:对产科医生和孕妇来说是一个警报吗?
Pub Date : 2018-12-31 DOI: 10.3126/mjpahs.v1i2.23402
P. Dhungana, R. Adhikari, Prem Raj Pageni, A. Koirala
Introduction: Fetal activity serves as an indirect measure of the fetus central nervous system integrity and function. Regular fetal movement can be regarded as an expression of fetal wellbeing. Maternal perception of decreased fetal movement is associated with poor feto-maternal outcome. This study is to find out feto-maternal outcome in cases of decreased fetal movement, done by assessing fetal heart rate (FHR) correlating with cardiotocography (CTG) and USG (ultrasonography) findings, Apgar score and meconium in amniotic fluid. Materials and method: This was a hospital based, prospective comparative study done in Patan Academy of Health Sciences, Lalitpur, Nepal. The sample size was 200; 100 cases of decreased fetal movement versus 100 cases of good fetal movement at same gestational age in weeks. Data processing was done in SPSS version 20.0 (SPSS, Chicago, IL, USA) and calculated by chisquare test. P value less than 0.05 was considered significant. Results: Significant difference was found in fetal kick chart counting. In the decreased fetal movement group, 16% had oligohydraminos, 3% had polyhydraminos and 5% had non reassuring CTG and 4% had abnormal heart rate detected clinically. There was statistically significant difference observed between the two groups in labor induction, cesarean section, meconium stain liquor, cord around the neck and different neonatal morbidities. Conclusion: Decreased fetal movement is associated with poor fetomaternal outcome. Improved vigilance, early identification, further evaluation with CTG, USG and proper management of these pregnancies have favourable pregnancy outcome.
胎儿活动是衡量胎儿中枢神经系统完整性和功能的一种间接指标。正常胎动可视为胎儿健康的一种表现。母体对胎动减少的感知与不良的胎母结局有关。本研究通过评估胎儿心率(FHR)与超声心动图(CTG)、超声心动图(USG)、Apgar评分和羊水胎粪的相关性,探讨胎动减少的胎母结局。材料和方法:本研究是在尼泊尔拉利特普尔帕坦健康科学院进行的一项基于医院的前瞻性比较研究。样本量为200人;100例胎动减少与100例胎动良好在相同胎龄周。数据处理采用SPSS 20.0版本(SPSS, Chicago, IL, USA),采用chisquare检验计算。P值小于0.05为显著性。结果:两组胎儿踢腿计数差异有统计学意义。胎动减少组16%出现低水合氨基酸,3%出现多水合氨基酸,5%出现CTG不稳定,4%出现临床心率异常。两组在引产、剖宫产、胎粪染色液、脐带绕颈及不同新生儿发病率方面比较,差异均有统计学意义。结论:胎动减少与不良胎产结局有关。提高警惕,早期发现,进一步评估CTG, USG和适当的管理这些妊娠有良好的妊娠结局。
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引用次数: 1
Is Urine dipstick as accurate as 24 hour urine protein? A Comparative Study 尿试纸和24小时尿蛋白一样准确吗?比较研究
Pub Date : 2018-12-31 DOI: 10.3126/MJPAHS.V1I2.23408
R. Adhikari, G. Sharma, P. Dhungana, K. Adhikari
Introduction: Hypertensive disorder in pregnancy (HDP) is one of the most common medical complications affecting approximately 5-10% of pregnancies. It remains a major cause of maternal/perinatal mortality and morbidity. Proteinuria is a sign of preeclampsia where there is >300 mg of protein in 24 hour urine collection. This usually correlates with 30mg/dl or 1+ reading in a random urine specimen. The main objective of this study is to find out whether urine dipstick correlates with 24 hour urine protein. Methodology: This is a hospital based comparative study, where proteinuria by dipstick method was compared with 24 hour urinary protein in 60 cases of pre eclampsia at Paropakar Maternity and Women’s Hospital, Thapathali, Kathmandu. Results: The dipstick method of detecting proteinuria significantly correlated with the total 24 hour urine protein excretion by Esbach Albuminometer. A dipstick factor of ≥300mg/24 hour indicates proteinuria with sensitivity of 97.5%, specificity of 65%, positive predictive value of 84.78% and negative predictive value of 92.85%. 3+ value in dipstick had high significance with 24 hour urine protein by Esbach’s Albuminometer (R=0.983 ). The cost of dipstick was Nepalies Rs (NPR) 14 in comparison to 24 hour dipstick which cost NPR 80.Time needed to get report was immediate in case of dipstick but takes 48-50 hour in case of 24 hour urine protein. Conclusion: Timely collection of six hourly urine for detection of proteinuria by dipstick is comparable to 24 hour urinary protein determination in laboratory by Esbach Albuminometer, which is more time consuming and expensive.
妊娠期高血压疾病(HDP)是最常见的医学并发症之一,影响约5-10%的妊娠。它仍然是孕产妇/围产期死亡率和发病率的一个主要原因。蛋白尿是子痫前期的征兆,24小时尿液中蛋白质含量大于300毫克。这通常与随机尿液标本中30mg/dl或1+读数有关。本研究的主要目的是了解尿试纸是否与24小时尿蛋白相关。方法:这是一项以医院为基础的比较研究,将加德满都塔帕塔利Paropakar妇产医院60例先兆子痫患者的尿蛋白与试纸法尿蛋白进行比较。结果:试纸法检测蛋白尿与Esbach蛋白计24小时尿蛋白总排泄量有显著相关性。试纸因子≥300mg/24小时提示蛋白尿,敏感性97.5%,特异性65%,阳性预测值84.78%,阴性预测值92.85%。Esbach 's Albuminometer检测24小时尿蛋白时,试纸3+值具有较高的统计学意义(R=0.983)。油尺的成本是尼泊尔卢比(尼泊尔卢比)14,而24小时油尺的成本是尼泊尔卢比80。如果是试纸,需要立即得到报告,但如果是24小时尿蛋白,则需要48-50小时。结论:用试纸法及时采集6小时尿液检测蛋白尿与实验室用Esbach白蛋白仪检测24小时尿蛋白相当,但前者耗时且费用昂贵。
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引用次数: 1
Study of Prevalence, Risk Factors and Hematological Parameters in Children Suffering from Iron Deficiency Anemia in a Tertiary Care Centre in Pokhara 博卡拉三级保健中心缺铁性贫血儿童患病率、危险因素和血液学参数的研究
Pub Date : 2018-12-31 DOI: 10.3126/MJPAHS.V1I2.23397
A. Paudel, K. Malla, S. Shrestha, S. Paudel, D. Paudel, R. Bastola, Yagyaraj Sigdel, R. Gurung
Introduction: Iron deficiency anemia (IDA) is the most common anemia worldwide. It adversely affects the physical growth, cognition, behavior and the immune status of infants and children. There are limited number of studies in Nepal analyzing its prevalence, risk factors and diagnosis in pediatric population. Restriction of analgesics intake, increased intake of iron rich food and deworming are important determinants in the disease management. Methods: Hospital based prospective comparative study was conducted in the Department of Pediatrics in Manipal Teaching Hospital from December 2014 to December 2016 enrolling all children aged 6 months to 5 years with anemia. Demographic profile, clinical features and information regarding risk factors were noted along with detailed physical examination. Iron profile was done to confirm diagnosis of IDA. Data was analyzed using SPSS 21. Results: Out of 168 anemic children, 110 (65.45%) children were diagnosed as IDA. Dietary factors, pica and intake of analgesics/antipyretics were major risk factors. Serum iron, serum ferritin, transferrin saturation were low whereas total iron binding capacity was high in IDA. Conclusion: Iron deficiency anemia is a common, preventable and easily treatable disease which has potentially serious consequences if not treated. Non compliance to exclusive breastfeeding in the first 6 months of life, introduction of cow’s/buffalo’s milk in the first year, pica and rampant use of analgesics/antipyretics are major risk factors.  
缺铁性贫血(IDA)是世界上最常见的贫血。它对婴儿和儿童的身体发育、认知、行为和免疫状况产生不利影响。在尼泊尔,分析其在儿科人群中的患病率、危险因素和诊断的研究数量有限。限制止痛药的摄入,增加富含铁的食物的摄入和驱虫是疾病管理的重要决定因素。方法:于2014年12月至2016年12月在马尼帕尔教学医院儿科进行以医院为基础的前瞻性比较研究,纳入所有6个月~ 5岁贫血患儿。统计资料、临床特征和有关危险因素的信息与详细的体格检查一起被记录下来。铁谱检查证实了IDA的诊断。数据采用SPSS 21进行分析。结果:168例贫血患儿中有110例(65.45%)诊断为IDA。饮食因素、异食癖和镇痛/解热药物的摄入是主要的危险因素。IDA患者血清铁、铁蛋白、转铁蛋白饱和度低,总铁结合力高。结论:缺铁性贫血是一种常见、可预防、易治疗的疾病,但若不及时治疗,可能造成严重后果。在生命的前6个月不遵守纯母乳喂养,在第一年引入牛奶/水牛奶,异食癖和大量使用镇痛药/退烧药是主要的危险因素。
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引用次数: 1
Fine needle Aspiration Cytology of various Head and Neck Swellings 头颈部各种肿肿的细针抽吸细胞学检查
Pub Date : 2018-12-31 DOI: 10.3126/MJPAHS.V1I2.23398
L. Banstola, Swasti Sharma, Bijaya Gautam
Background: Head and neck swelling is a frequently encountered complaint in the outpatient department. A wide plethora of conditions give rise to head and neck lumps. Sometimes the diagnosis of these lesions is apparent from the site and associated features, while at other times the cause for mass in this region can be confusing. Fine needle aspiration cytology has emerged as a reliable tool for clinching the diagnosis in head and neck swellings. Methods and Materials: A retrospective study was conducted in the department of Pathology, Pokhara Academy of Health Sciences, Western Regional Hospital, Pokhara. Details of diagnosed cases of HN swellings from the period of November 2015 to February 2018 were obtained from recorded data. Descriptive statistics was applied from the data collected for analysis. Results: Out of total 456 patients included from a period of 28 months, female patients outnumbered male patients by 1.5 times. The most common age group of presentation for head and neck swellings was observed to be 20-29 years, with 93 patients which comprised of 20.39% of total. Highest incidence was that of lymph node swellings (55.04%) followed by thyroid swellings (21.49%). Conclusion: Lymph node pathology was determined to be the commonest cause for head and neck mass. FNAC is a reliable and inexpensive means in investigating such lesions, which provides immense help in treatment of patients.
背景:头颈部肿胀是门诊常见的主诉。各种各样的情况都会导致头颈部肿块。有时,这些病变的诊断从部位和相关特征是显而易见的,而在其他时候,该区域肿块的原因可能令人困惑。细针抽吸细胞学已成为头颈部肿胀诊断的可靠工具。方法与材料:回顾性研究在博克拉拉市西部地区医院博克拉拉市卫生科学院病理科进行。从记录数据中获得2015年11月至2018年2月期间确诊的HN肿胀病例的详细信息。对收集的数据进行描述性统计分析。结果:在28个月的456例患者中,女性患者数量是男性患者的1.5倍。头颈部肿胀最常见的表现为20-29岁,93例,占总数的20.39%。以淋巴结肿大发生率最高(55.04%),其次为甲状腺肿大(21.49%)。结论:淋巴结病理是头颈部肿块最常见的病因。FNAC是一种可靠且廉价的检查此类病变的方法,为患者的治疗提供了巨大的帮助。
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引用次数: 4
Extracorporeal shock wave lithotripsy in the management of upper urinary tract stone: a single institute experience 体外冲击波碎石术治疗上尿路结石:单一研究所的经验
Pub Date : 2018-12-31 DOI: 10.3126/mjpahs.v1i2.23405
D. Adhikari, D. Shrestha, A. Shrestha
Introduction: The aim of the study was to observe the success rate of extracorporeal shock wave lithotripsy (ESWL) in the management of upper urinary tract stones. Materials and Methods: This retroprospective study was conducted in Pokhara Kidney stone Centre, Pokhara, Kaski, Nepal from January 2017 to January 2018. Seventy nine patients were selected in this study with upper urinary tract stone, size less than 20 mm. Results: Seventy four (93.67%) patients were successfully treated in initial use of shock wave and 5 (6.32%) patients required repetition. Conclusion: Overall satisfactory success rate was observed using ESWL for the upper urinary tract stone. Careful selection of patient, stone size and Hounsfield unit (HU) is advisable.
前言:本研究旨在观察体外冲击波碎石术(ESWL)治疗上尿路结石的成功率。材料和方法:本回顾性研究于2017年1月至2018年1月在尼泊尔Kaski Pokhara的Pokhara肾结石中心进行。本研究选取79例上尿路结石小于20mm的患者。结果:首次使用冲击波治疗成功74例(93.67%),需重复使用5例(6.32%)。结论:体外冲击波碎石治疗上尿路结石的成功率总体满意。建议仔细选择患者、结石大小和霍氏单位(HU)。
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引用次数: 1
Non-locking buttress plate in distal tibial metaphyseal fractures 非锁定支撑钢板治疗胫骨远端干骺端骨折
Pub Date : 2018-12-31 DOI: 10.3126/MJPAHS.V1I2.23401
N. Lamichhane, B. B. Kc, C. Mishra, S. Dhakal
Background: Treatment of distal tibial metaphyseal fractures is often challenging and no single technique has been unanimously advocated. Open reduction and internal fixation with plates and screws allows better restoration of anatomical alignment but with more soft tissue complication. Simultaneous fixation of the fibula is not universally carried out. This study aims at evaluation of the outcome of plating technique and the effect of fixation of fibula fracture in treatment of distal tibial metaphyseal fractures. Material and methods: Thirty-one cases (14 cases in Group A with concomitant distal fibula fracture and 17 cases in Group B without distal fibula fracture) were analyzed retrospectively for the mean duration of full weight bearing, mean union time and complications, and compared. Results: The mean time for full weight bearing and radiological union in our study was 14.2 weeks (15.9 in Group A and 13.1 in Group B) and 23.8 weeks (26.6 in Group A and 21.5 in Group B) respectively. 16.1% of cases had post-operative complications including one case of deep infection and malalignment of 6 degree varus (following delayed union) was seen in one case of Group A. Range of motion (ROM) at ankle was not problem in any of the cases except the one delayed union which had 5 degrees of dorsiflexion and 15 degrees of plantiflexion. Conclusion: Open reduction and internal fixation with plate and screws in distal tibial metaphyseal fracture is more economic means of treatment modality with comparable incidence of post-union malalignment and union time,though more soft tissue complications compared to other modalities. Fixation of fibula fracture aids in reducing the incidence of malalignment.
背景:胫骨远端干骺端骨折的治疗通常是具有挑战性的,没有一种技术被一致提倡。切开复位和钢板螺钉内固定可以更好地恢复解剖对齐,但有更多的软组织并发症。腓骨同时固定并不普遍。本研究旨在评价钢板技术及腓骨骨折内固定治疗胫骨远端干骺端骨折的效果。材料与方法:回顾性分析31例(A组合并腓骨远端骨折14例,B组无腓骨远端骨折17例)平均完全负重时间、平均愈合时间及并发症,并进行比较。结果:我们的研究中完全负重和放射愈合的平均时间分别为14.2周(A组15.9周,B组13.1周)和23.8周(A组26.6周,B组21.5周)。16.1%的病例出现术后并发症,其中a组1例出现深度感染和6度内翻错位(延迟愈合),除1例延迟愈合为5度背屈和15度跖屈外,其他病例踝关节活动范围均无问题。结论:切开复位钢板螺钉内固定治疗胫骨远端干骺端骨折是一种更为经济的治疗方式,其愈合后畸形发生率和愈合时间相当,但与其他方式相比,软组织并发症较多。腓骨骨折内固定有助于减少不对准的发生率。
{"title":"Non-locking buttress plate in distal tibial metaphyseal fractures","authors":"N. Lamichhane, B. B. Kc, C. Mishra, S. Dhakal","doi":"10.3126/MJPAHS.V1I2.23401","DOIUrl":"https://doi.org/10.3126/MJPAHS.V1I2.23401","url":null,"abstract":"Background: Treatment of distal tibial metaphyseal fractures is often challenging and no single technique has been unanimously advocated. Open reduction and internal fixation with plates and screws allows better restoration of anatomical alignment but with more soft tissue complication. Simultaneous fixation of the fibula is not universally carried out. This study aims at evaluation of the outcome of plating technique and the effect of fixation of fibula fracture in treatment of distal tibial metaphyseal fractures. \u0000Material and methods: Thirty-one cases (14 cases in Group A with concomitant distal fibula fracture and 17 cases in Group B without distal fibula fracture) were analyzed retrospectively for the mean duration of full weight bearing, mean union time and complications, and compared. \u0000Results: The mean time for full weight bearing and radiological union in our study was 14.2 weeks (15.9 in Group A and 13.1 in Group B) and 23.8 weeks (26.6 in Group A and 21.5 in Group B) respectively. 16.1% of cases had post-operative complications including one case of deep infection and malalignment of 6 degree varus (following delayed union) was seen in one case of Group A. Range of motion (ROM) at ankle was not problem in any of the cases except the one delayed union which had 5 degrees of dorsiflexion and 15 degrees of plantiflexion. \u0000Conclusion: Open reduction and internal fixation with plate and screws in distal tibial metaphyseal fracture is more economic means of treatment modality with comparable incidence of post-union malalignment and union time,though more soft tissue complications compared to other modalities. Fixation of fibula fracture aids in reducing the incidence of malalignment.","PeriodicalId":256896,"journal":{"name":"Medical Journal of Pokhara Academy of Health Sciences","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132981851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Comparative Study of Single Layer Versus Double layer Intestinal Anastomosis 单层与双层肠吻合术的比较研究
Pub Date : 2018-12-31 DOI: 10.3126/mjpahs.v1i2.23403
A. Gurung, S. Shrestha, D. Shrestha, S. Paudel, D. Shrestha, A. Shrestha, Dilip Baral
Objective: To determine the efficacy of single layer intestinal anastomosis to double layer technique in terms of anastomotic healing. Materials and Methods: Fifty patients who underwent intestinal anastomosis in the Department of Surgery, Western Regional Hospital from June 2014 to May 2016 were taken for this comparative study and divided equally in two groups, 25 each (single layer and double layer). Results: Of the total fifty cases, twenty-five cases included in each group, there was no leakage in single layer group while 1 patient had leakage in double layer group which was statistically insignificant. Conclusion: Single layer interrupted intestinal anastomosis is simple to carry out and is as efficacious as double layer anastomosis in terms of postoperative anastomotic leak.
目的:比较单层肠吻合术与双层肠吻合术在吻合口愈合方面的疗效。材料与方法:选取2014年6月至2016年5月在西部地区医院外科行肠吻合术的患者50例进行对比研究,平均分为两组,每组25例(单层和双层)。结果:50例患者中,每组25例,单层组无渗漏,双层组1例,差异均无统计学意义。结论:单层间断肠吻合术操作简单,在术后吻合口漏方面与双层吻合术效果相当。
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引用次数: 0
Short term outcome in severe alcoholic hepatitis patients treated with Methylprednisolone plus N acetylcysteine or Pentoxifylline plus N acetylcysteine 甲泼尼龙加N乙酰半胱氨酸或己酮茶碱加N乙酰半胱氨酸治疗重度酒精性肝炎患者的短期疗效
Pub Date : 2018-12-31 DOI: 10.3126/MJPAHS.V1I2.23389
K. Regmi, A. Mishra, S. Kc, D. Sharma, J. K. Shrestha, Sushil Prajapati, D. Khadka
Introduction: Severe Alcoholic hepatitis (AH) is an acute form of alcohol induced liver injury. Often it present as fetal diseases with very high (30-50%) short term (28 days) mortality. This study was conducted from period May 2016 to July 2017 in Liver unit, Bir hospital. The main objective was to find out 28 days mortality in patients with severe alcoholic hepatitis who had Discriminant function (DF) ≥ 32. This was a prospective, comparative, randomized interventional hospital based study. Methodology: Hundred and ten diagnosed patients of severe alcoholic hepatitis who fulfilled the criteria were enrolled and randomized into two groups (odd number and even number). Group 1 received methylprednisolone and group 2 received pentoxifylline for 28 days. In both groups N acetylcysteine were added. Lille score was calculated in methylprednisolone group at day 7 and patients with score of ≤ 0.45 were continued methylprednisolone for total 28 days otherwise stopped. Data were recollected at day 28. They were compared in relation to survival, complications of drugs and causes of mortality. Results: Mean age of presentation were 40.21±10.5 yrs in methylprednisolone and 42.1±12.1 yrs in pentoxifylline group. In both groups complications were nausea, vomiting, bloating, anorexia and swelling of limb. However, hyperglycemia (16.4%) and renal impairment (9.1%) were more common in methylprednisolone group. Mortality rates were 34.5% in methylprednisolone and 37.8% in pentoxifylline group within 28 days. Common causes of death in both groups were hepatic encephalopathy, hepatorenal syndrome, sepsis or the cause was undetermined. Conclusion: Alcoholic hepatitis is common manifestation of alcoholic liver disease with high short term mortality in both the groups however adverse effects of drugs are more common in methylprednisolone groups.
重度酒精性肝炎(AH)是一种急性酒精性肝损伤。通常表现为胎儿疾病,短期(28天)死亡率非常高(30-50%)。本研究于2016年5月至2017年7月在Bir医院肝脏科进行。主要目的是找出判别功能(DF)≥32的严重酒精性肝炎患者的28天死亡率。这是一项前瞻性、比较性、随机介入医院研究。方法:选取符合诊断标准的110例重度酒精性肝炎患者,随机分为奇数组和偶数组。1组给予甲基强的松龙治疗,2组给予己酮可可碱治疗,疗程28 d。两组均添加N型乙酰半胱氨酸。甲强的松龙组在第7天计算里尔评分,评分≤0.45的患者继续甲强的松龙治疗28天,否则停止治疗。第28天收集数据。他们的生存、药物并发症和死亡原因进行了比较。结果:甲泼尼龙组平均发病年龄为40.21±10.5岁,己酮可可碱组平均发病年龄为42.1±12.1岁。两组并发症均为恶心、呕吐、腹胀、厌食和肢体肿胀。然而,甲基强的松龙组高血糖(16.4%)和肾功能损害(9.1%)更为常见。甲泼尼龙组28 d内死亡率为34.5%,己酮可可碱组为37.8%。两组的常见死亡原因均为肝性脑病、肝肾综合征、败血症或原因不明。结论:酒精性肝炎是酒精性肝病的常见表现,两组均有较高的短期死亡率,但药物不良反应在甲基强的松龙组更为常见。
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引用次数: 0
Metabolic Syndrome in Subclinical and Overt Hypothyroidism 亚临床和显性甲状腺功能减退的代谢综合征
Pub Date : 2018-12-31 DOI: 10.3126/MJPAHS.V1I2.23396
B. Thapa, M. Tiwari, S. Gurung, Manish Gurung, Mukunda Kalauni, B. Bhatta
Background: Sub-clinical hypothyroidism (SCH), overt hypothyroidism and metabolic syndrome (MetS) are recognized risk factors for atherosclerotic cardiovascular disease and Type 2 diabetes mellitus (DM- II).Thyroid function affects MetS parameters including blood pressure (BP), fasting blood sugar (FBS), serum triglycerides (TG) and high density lipoprotein cholesterol (HDL-C). But the relationship between MetS and thyroid functions is yet to be identified clearly. The present study is to investigate the frequency of MetS in patients of SCH and overt hypothyroidism. Materials and Methods: A hospital based cross–sectional study was conducted at Swastik referral laboratory and research centre. In this study, 50 patients with overt hypothyroidism, 50 patients with SCH and 129 euthyroid controls were enrolled. National Cholesterol Education Program- Adult Treatment Panel III (NCEP-ATP III; 2005) revision criteria were used to diagnose metabolic syndrome. Thyroid function test (TFT: FT3, FT4 and TSH) was done by using chemiluminescence immunoassay (CLIA) and other tests by using a semi-auto analyzer. ANalysis Of VAriance (ANOVA) test was performed using SPSS (version 16.0). Result: There was a significant difference in the mean of the waist circumference (p=0.031), BP systolic (p=0.010), BP diastolic (p<0.001)), FBS (p=0.001), serum HDL-C (p=0.031) and serum TG (p=0.003) between control, subclinical and overt hypothyroidism group (p<0.001). Prevalence of MetS was 25.6 % in euthyroid controls whereas 44.0% in the SCH group and 62.0% in the overt hypothyroid group (p<0.001). Conclusion: Thyroid dysfunction may be responsible for the development of metabolic syndrome.
背景:亚临床甲状腺功能减退(SCH)、显性甲状腺功能减退和代谢综合征(MetS)是公认的动脉粥样硬化性心血管疾病和2型糖尿病(DM- II)的危险因素,甲状腺功能影响MetS参数包括血压(BP)、空腹血糖(FBS)、血清甘油三酯(TG)和高密度脂蛋白胆固醇(HDL-C)。但是MetS和甲状腺功能之间的关系还没有被明确地确定。本研究的目的是探讨甲状腺功能减退症和甲状腺功能减退症患者发生met的频率。材料和方法:在纳粹十字转诊实验室和研究中心进行了一项基于医院的横断面研究。本研究纳入50例显性甲状腺功能减退患者、50例SCH患者和129例甲状腺功能正常对照。国家胆固醇教育计划-成人治疗小组III (NCEP-ATP III);2005)修订标准用于诊断代谢综合征。甲状腺功能检测(TFT: FT3、FT4、TSH)采用化学发光免疫分析法(CLIA),其他检测采用半自动分析仪。采用SPSS (version 16.0)进行方差分析(ANOVA)检验。结果:对照组、亚临床及显性甲状腺功能减退组在腰围(p=0.031)、收缩压(p=0.010)、舒张压(p<0.001)、FBS (p=0.001)、血清HDL-C (p=0.031)、血清TG (p=0.003)等指标上均有显著性差异(p<0.001)。甲状腺功能正常对照组的met患病率为25.6%,而SCH组为44.0%,明显甲状腺功能减退组为62.0% (p<0.001)。结论:甲状腺功能障碍可能与代谢综合征的发生有关。
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引用次数: 1
期刊
Medical Journal of Pokhara Academy of Health Sciences
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