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Efficacy of topical terbinafine and clotrimazole in the treatment of dermatophytoses: a Clinical and Microbiological Comparision 外用特比萘芬和克霉唑治疗皮肤癣的疗效:临床和微生物学比较
Pub Date : 2018-06-04 DOI: 10.3126/mjpahs.v1i1.22457
A. Nepal
Background: Dermatophytoses have a high prevalence worldwide and also in Nepal. Large scale studies with different antifungal agents for long fol¬low up periods to assess the long term outcome of treatments together with culture sensitivity testing are required to confirm the elimination of the fungi. Materials and Methods: Total of 97 patients were enrolled, 48 patients received treatment with terbinafine 1% cream for 2 weeks and 49 patients received clotrimazole 1% cream for 4 weeks. Clinical evaluation and microscopic examination of the potassium hydroxide (KOH) mount were done at presentation, at week 2 and at week 4. Clinical assessment scoring (CAS) and Mycological cure rate were compared between the study groups. Results: Terbinafine cured more cases of dermatophytoses compared to clotrimazole. The clinical cure rate was not statistically different among cases of tinea pedis. Terbinafine was better among cases of tinea cruris and tinea corporis only at the end of week 4. Mycological cure rate was higher for terbinafine both at the end of week 2 and week 4.
背景:皮癣在世界范围内和尼泊尔都有很高的流行率。需要对不同的抗真菌药物进行长期随访的大规模研究,以评估治疗的长期结果,并进行培养敏感性测试,以确认真菌的消除。材料与方法:共纳入97例患者,48例患者使用1%特比萘芬乳膏治疗2周,49例患者使用1%克曲霉唑乳膏治疗4周。临床评估和显微镜检查氢氧化钾(KOH)坐垫在提出,在第2周和第4周。比较两组患者临床评估评分(CAS)和真菌学治愈率。结果:特比萘芬比氯霉唑治愈率高。足癣患者的临床治愈率差异无统计学意义。特比萘芬仅在第4周结束时对股癣和体癣的病例效果更好。在第2周和第4周结束时,特比萘芬的真菌学治愈率更高。
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引用次数: 0
Incidence of Superficial Port Site Infection in Laparoscopic Cholecystectomy in relation to Spilt Stone and Bile Spillage 腹腔镜胆囊切除术中浅孔部位感染与结石和胆汁溢出的关系
Pub Date : 2018-06-04 DOI: 10.3126/mjpahs.v1i1.22459
S. Paudel, N. Gurung, Dhruva Bahadur Adhikari, A. Acharya, S. Shrestha, A. Gurung, D. Shrestha, A. Paudel
Introduction: Laparoscopic cholecystectomy is the choice of operation for symptomatic gallstones. Gallstone and bile spillage can occur during laparoscopic cholecystectomy during dissection by cautery or due to perforation of gall bladder by grasper. The complication of spilt stone and bile may range from simple superficial surgical site infection, adhesion, obstruction, abscess formation to none. Methods: This study was conducted at Western Regional Hospital (WRH), Pokhara from July 2015 to December 2016. A total of one hundred and twenty patients who underwent laparoscopic cholecystectomy were included. All patients’ age, sex, pre-operative ultrasound findings, intra operative spillage of stone and bile and post-operative superficial surgical site infection were noted. Statistical analysis was done using Microsoft Excel software and SPSS-21. Result obtained from the study was discussed with reference to current world literature. Results: Out of one hundred and twenty patients, one hundred and nine were female and eleven were male with mean age of 42.68 years. Spillage of stones and bile occurred in twelve patients (10%). Spillage of stone and bile was common with multiple stones. Only four patients (one male and three females) developed superficial port site infection (3.3%). Two patients among spillage and two among non spillage developed superficial surgical site infection (p<0.05). Most common organism was Staphylococcus aureus followed by Escherichia coli. Conclusion: The incidence of split stone or bile is 10 % and is common with multiple gallstones. The chance of superficial surgical site infection is more in male patients and with spillage of stone and bile.
腹腔镜胆囊切除术是治疗症状性胆结石的首选手术方式。在腹腔镜胆囊切除术中,胆石和胆汁溢出可发生在烧灼术中或由于抓手穿孔胆囊。结石和胆汁外溢的并发症可能从单纯的浅表手术部位感染、粘连、阻塞、脓肿形成到无。方法:本研究于2015年7月至2016年12月在博克拉西部地区医院(WRH)进行。共纳入120例接受腹腔镜胆囊切除术的患者。记录所有患者的年龄、性别、术前超声表现、术中结石、胆汁渗漏及术后手术部位浅表感染情况。采用Microsoft Excel软件和SPSS-21进行统计分析。并结合国内外文献对研究结果进行了讨论。结果:120例患者中,女性109例,男性11例,平均年龄42.68岁。12例(10%)患者发生结石和胆汁溢出。结石和胆汁的溢出是常见的多发性结石。仅有4例(男1例,女3例)发生浅孔部位感染(3.3%)。渗漏组2例,非渗漏组2例发生手术部位浅表感染(p<0.05)。最常见的细菌是金黄色葡萄球菌,其次是大肠杆菌。结论:结石或胆汁碎裂发生率为10%,多见于多发性胆结石。男性患者易发生手术部位浅表感染,并伴有结石和胆汁外溢。
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引用次数: 1
Profile of Risk Factors Associated with Stillbirth at Western Regional Hospital 西部地区医院死产相关危险因素分析
Pub Date : 2018-06-04 DOI: 10.3126/MJPAHS.V1I1.22453
Rashmi Regmi, Shyam Sundar Parajuly, Dela Singh, Nabin Shrestha, Srijana Sharma
Background: Stillbirth (SB) incidents are one of the most common adverse outcomes to occur during pregnancy. Studies indicate that approximately 3.3 million stillbirths are reported annually across the developing world. Institutional registration and under reporting of still birth to an authorized centre is a common problem. Objective: The objective of this study is to find out the incidence of SB after 28 weeks gestation and to find out the associated risk factors at Western Regional Hospital of Nepal. Materials and Methods: This is a cross sectional study carried out at Western Regional Hospital. Stillbirth babies born after 28 weeks of gestation or birth weight ≥ 1 kilogram and their mothers were recruited for the study. Intrapartum stillbirths were included despite of their ages, races or socio-economic status. Descriptive analysis was done on the data. Results: There were 3380 deliveries during the period of study. Among them, 50 cases were stillborn babies with a rate of 14 per thousand deliveries. The major risk factors associated were oligohydramnios, decreased fetal movement, growth restriction, meconium stained liquor and cord prolapse. Conclusion: Oligohydramnios (amniotic fluid index < 5cm) was the most common risk factor for stillbirth. Early identification and appropriate perinatal management could help to promote perinatal health.
背景:死胎(SB)事件是妊娠期间最常见的不良后果之一。研究表明,发展中国家每年报告的死产约为330万例。机构登记和未向授权中心报告死胎是一个常见问题。目的:本研究的目的是了解尼泊尔西部地区医院妊娠28周后SB的发生率及相关危险因素。材料和方法:本研究是在西部地区医院进行的横断面研究。研究招募了妊娠28周后出生或出生体重≥1公斤的死胎婴儿及其母亲。无论年龄、种族或社会经济地位如何,产时死产也包括在内。对数据进行描述性分析。结果:研究期间共分娩3380例。其中,死产婴儿50例,死亡率为千分之十四。主要危险因素为羊水过少、胎动减少、生长受限、胎粪染色液和脐带脱垂。结论:羊水过少(羊水指数< 5cm)是死产最常见的危险因素。早期发现和适当的围产期管理有助于促进围产期健康。
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引用次数: 0
Goodwill message from the Vice Chancellor 副校长的亲善致辞
Pub Date : 2018-06-04 DOI: 10.3126/mjpahs.v1i1.22448
B. Thapa
It gives me great pleasure to know that Pokhara Academy of Health Sciences, (PAHS) has come out with its first publication of medical journal of Pokhara Academy of Health Sciences (MJPAHS). This can be a beginning of implementation of the policy of federal Government of Nepal to set at least one government medical college in each province. PAHS has been established in the year 2016 (2072 B.S) with an aim to begin postgraduate medical education in province number 4 and provide quality care and affordable medical service to all, in general, poor and marginalized people in particular. It also aims to carry out scientific research and study in different health related areas of this region. Accordingly we have formed IRC, Medical Education Department and Journal Editorial Board to carry out all its activities. This journal publication has been possible only because of collaborative, cooperative and untiring efforts of editorial board. I congratulate Dr. Bhogendra Bahadur KC and all other members of Editorial Board for this great job. I am sure this journal will fulfil the academic needs of all faculties and students and academics of different health institutes of this region.
我非常高兴地得知,博卡拉卫生科学院(PAHS)出版了第一本《博卡拉卫生科学院医学杂志》(MJPAHS)。这可以成为实施尼泊尔联邦政府在每个省至少设立一所政府医学院的政策的开端。PAHS于2016年(2072 B.S)成立,目的是在第4省开始研究生医学教育,并向所有人,特别是穷人和边缘化人群提供优质护理和负担得起的医疗服务。它还旨在开展本地区不同卫生相关领域的科学研究。因此,我们成立了IRC、医学教育部和期刊编辑委员会来开展其所有活动。本刊的出版离不开编辑部的通力合作和不懈努力。我祝贺Bhogendra Bahadur KC博士和编委会所有其他成员的出色工作。我相信这本杂志将满足本地区各卫生机构所有教员、学生和学者的学术需求。
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引用次数: 0
Psychiatric Referral Pattern in a General Hospital 某综合医院精神病转诊模式
Pub Date : 2018-06-04 DOI: 10.3126/MJPAHS.V1I1.22456
L. Vaidya, Rajan Sharma
Background: The referral rates of psychiatric patients in Nepal are very low, considering the higher rates of psychiatric morbidity in patients who attend various departments of a general hospital. Studying the pattern of psychiatric referrals may facilitate the management of the mentally ill in a comprehensive and holistic manner. Materials and methods: The study was conducted at Western Regional Hospital (WRH) over the period of one year. The patients referred from different departments were assessed by the consultant psychiatrists. Result: A total of 816 patients were referred for psychiatric consultation out of which majority was from department of medicine and the most common reason for referral was anxiety disorder. Conclusion: Multi-disciplinary interaction is beneficial to identify the psychiatric morbidity in the patients who attend general hospital.
背景:尼泊尔精神病患者的转诊率非常低,考虑到在综合医院各个科室就诊的患者的精神病发病率较高。研究精神科转介模式,有助全面及整体地管理精神病患者。材料和方法:研究在西部地区医院(WRH)进行,为期一年。从不同科室转来的病人由精神科顾问进行评估。结果:共转诊精神科患者816例,其中内科患者居多,转诊原因以焦虑症居多。结论:多学科互动有助于识别综合医院住院患者的精神疾病。
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引用次数: 0
Anesthesia practice in cesarean delivery in tertiary care hospital: a retrospective observational study 三级医院剖宫产麻醉实践:回顾性观察研究
Pub Date : 2018-06-04 DOI: 10.3126/mjpahs.v1i1.22452
Rohini Sigdel, M. Lama, Sanish Gurung, S. Timilsina
Background: Regional anesthesia is being utilized as the preferred anesthetic technique for cesarean delivery worldwide. This study was performed to review cesarean delivery anesthetic practice in our institute which represents a tertiary care regional hospital. Methods: Data was collected regarding the number of cesarean delivery performed during the period of six months from January 2017 to June 2017 at Western Regional Hospital. Number of elective versus emergency cesarean delivery, mode of anesthesia and the reason for general anesthesia and complications was recorded. Results: The number of cesarean delivery was found to be 1174(26.41%) of total deliveries during the study period. Out of which, 64.82% were for emergency indication and 35.18% were elective cesarean delivery. Spinal anesthesia was utilized in 99.03% of elective cesarean section and 97.63% of emergency cesarean section. The percentage of cases performed under general anesthesia was 1.87%. Reasons for general anesthesia included inadequate subarachnoid block, fetal malpresentation, eclampsia and maternal comorbidities. Complications related to general anesthesia like failed intubation, airway difficulty related to general anesthesia and anesthesia related mortality was not encountered. Conclusion: Spinal anesthesia is utilized widely and safely in obstetric practice at our hospital. Use of labour epidural analgesia should be introduced and encouraged in our setting to minimize the side effects of single shot spinal anesthesia and to avoid general anesthesia when indicated.
背景:在世界范围内,区域麻醉被用作剖宫产的首选麻醉技术。本研究是为了回顾剖宫产麻醉实践在我们研究所代表三级保健地区医院。方法:收集西部地区医院2017年1月至2017年6月6个月剖宫产手术的数据。记录择期剖宫产与急诊剖宫产的数量、麻醉方式、全麻原因及并发症。结果:研究期间剖宫产1174例,占总分娩数的26.41%。其中急诊指征占64.82%,择期剖宫产占35.18%。选择性剖宫产的99.03%和急诊剖宫产的97.63%采用了脊髓麻醉。全麻下手术占1.87%。全麻的原因包括蛛网膜下腔阻滞不足、胎儿畸形、子痫和母体合并症。与全身麻醉相关的并发症如插管失败、与全身麻醉相关的气道困难和与麻醉相关的死亡率均未发生。结论:脊髓麻醉在我院产科实践中应用广泛、安全。在我们的情况下,应引入并鼓励使用分娩硬膜外镇痛,以尽量减少单针脊髓麻醉的副作用,并避免在需要时全身麻醉。
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引用次数: 2
The Efficacy of Medical Expulsion Therapy in Distal Ureteric Calculi 药物排出治疗输尿管远端结石的疗效观察
Pub Date : 2018-06-04 DOI: 10.3126/mjpahs.v1i1.22454
Dhurba Adhikari, D. Shrestha, S. Poudel
Objective: To evaluate the efficacy of tamsulosin in the treatment of distal ureteric calculi. Materials and Methods: Forty patients, who meet the in­clusion criteria, were selected for the prospective study. All these patients re­ceived tamsulosin 0.4 mg once before bed time for fourteen days to observe the effectiveness, side effects and stone expulsion rate. Results: The average time of stone expulsion was 8.03±2.80 days. The successful medical expul­sion was seen in 82.50%. About 7.5% complained of dizziness and headache, 2.5% complained of fatigue and postural hypotension. Conclusion: The use of tamsulosin was safe, effective and was associated with fewer side effects. Successful stone expulsion rate was observed in in selected cases.
目的:评价坦索罗辛治疗输尿管远端结石的疗效。材料和方法:选择符合纳入标准的40例患者进行前瞻性研究。所有患者均在睡前给予坦索罗辛0.4 mg 1次,连续用药14天,观察其疗效、不良反应及结石排出率。结果:结石排出时间平均为8.03±2.80 d。医疗驱逐成功率为82.50%。约7.5%的患者主诉头晕和头痛,2.5%主诉疲劳和体位性低血压。结论:坦索罗辛安全有效,副作用少。在选定的病例中观察到成功的结石排出率。
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引用次数: 0
Clinical and bacteriological profile of neonates admitted in the neonatal care unit of western regional hospital 西部地区医院新生儿监护室新生儿临床及细菌学分析
Pub Date : 2018-06-04 DOI: 10.3126/mjpahs.v1i1.22450
S. Shrestha, J. Ghimire, R. Bastola, R. Gurung
Background: Neonatal sepsis is leading cause of mortality in neonates. The organism responsible for sepsis differed depending on the site of Neonatal care unit and country. In this study, we aimed to look at cause of sepsis and antibiotic sensitivity. Materials and Methods: Neonates admitted in the neonatal care unit of western regional hospital from 14th August 2012 to 14th July 2014were included in the study. Septic workup was done and culture was sent. Results of culture sensitivity were noted along with the sensitivity pattern. Results: Neonatal sepsis accounted for 38 percent of total admission in the neonatal unit. Staphylococcus aureus was the most common organism isolated which was followed by Escherichia coli (E coli). Staphylococcus aureus isolated was sensitive to Cloxacillin in 97% of cases. There were 5 % mortalities during the study period. Conclusion: Neonatal sepsis was the most common reason for admission and staphylococcus aureus was the most common organism.
背景:新生儿败血症是新生儿死亡的主要原因。导致败血症的微生物因新生儿护理单位和国家的不同而不同。在这项研究中,我们旨在研究败血症的原因和抗生素敏感性。材料与方法:选取2012年8月14日至2014年7月14日在西部地区医院新生儿监护室住院的新生儿为研究对象。进行了脓毒性检查并进行了培养。并记录了培养敏感性的结果和敏感性模式。结果:新生儿败血症占新生儿住院总人数的38%。金黄色葡萄球菌是最常见的分离菌,其次是大肠杆菌。97%的金黄色葡萄球菌对氯西林敏感。在研究期间有5%的人死亡。结论:新生儿脓毒症是最常见的入院原因,金黄色葡萄球菌是最常见的病原菌。
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引用次数: 1
Ossicular Involvement and Types of Pathology in Chronic Otitis Media Squamous Active Disease 慢性中耳炎鳞状活动性疾病的听骨受累及病理类型
Pub Date : 2018-06-04 DOI: 10.3126/MJPAHS.V1I1.22460
Swasti Sharma
Background: Chronic otitis media (COM) squamous type is commonly as­sociated with cholesteatoma. In COM squamous type with active disease, there is retraction of pars flaccida or pars tensa with retention of squamous epithelial debris and is associated with inflammation and production of pus. It is potentially dangerous because it can cause resorption of bone, leading to ossicular erosion and destruction of bony plates of middle ear. The objective of this study is to determine the effect of chronic otitis media squamous type on the ossicular chain as well as to observe the types of pathology in this disease. Methods and materials: Fifty cases of chronic otitis media squa­mous type who underwent surgical management were included. The status of ossicular chain was evaluated intraoperatively. The type of pathology in­volving middle ear was also studied. Cases admitted for revision surgery were excluded from the study. Results: Of the total fifty cases, ossicular changes were observed in forty eight cases and in two cases all ossicles were intact. Long process of incus is the most frequently involved ossicle. The most common pathology was found to be mixed type (52%). Conclusion: The conclusion of this study is that ossicular chain is commonly involved in chronic otitis media squamous type and mixed pathology consisting of cholesteatoma and granulation tissue is the most frequent pathology.
背景:慢性中耳炎(COM)鳞状型通常与胆脂瘤相关。有活动性疾病的COM鳞状型患者,有松弛部或张力部的收缩,并保留鳞状上皮碎片,并与炎症和脓的产生有关。它有潜在的危险,因为它会引起骨的吸收,导致听骨侵蚀和中耳骨板的破坏。本研究的目的是确定慢性中耳炎鳞状型对听骨链的影响,并观察该疾病的病理类型。方法与材料:对50例经手术治疗的慢性中耳炎患者进行回顾性分析。术中评估听骨链状态。并对中耳病变类型进行了研究。接受翻修手术的病例被排除在研究之外。结果:50例听骨病变48例,2例听骨完整。砧骨长突是最常受累的听骨。最常见的病理为混合型(52%)。结论:本研究结论:慢性中耳炎鳞状型常见听骨链病变,以胆脂瘤和肉芽组织混合病理最为常见。
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引用次数: 0
Dreams and ability to recall: Comparison between propofol and ketamine in patients undergoing surgery under IVA 梦和回忆能力:异丙酚和氯胺酮在IVA下手术患者中的比较
Pub Date : 2018-06-04 DOI: 10.3126/mjpahs.v1i1.22451
M. Lama, Rohini Sigdel, Sanish Gurung, S. Timilsina
Background: Dreaming during anaesthesia is a common phenomenon. Dreams can occur with both inhalational agents as well as intravenous agents (IVA) like propofol and ketamine. But there are concerns like patient awareness, dreams and other untoward effects that may be associated with IVA. We have conducted this study to quantify the incidence of dreaming during IVA with propofol or ketamine. Methods: Sixty-nine patients aged 18 to 60 years scheduled for short procedures lasting from 5 to 25 minutes under IVA were randomized into two groups – group propofol or group ketamine. All the patients received midazolam and fentanyl intravenously. Then, patients in group propofol received propofol and those in ketamine group received ketamine for induction and maintenance of anaesthesia. After the end of surgery, when the patient were fully recovered from anaesthesia, patients were interviewed about occurrence of dreams and their ability to recall the dreams. Results: There were 35 patients in group propofol and 34 patients in group ketamine. The incidence of dreaming during anaesthesia was greater in patients of ketamine group, 23 (67.65%), when compared to propofol group, 7 (20%) (p < 0.001). Among the dreamers, 6 patients in the ketamine group and only 1 patient in the propofol group were able to recall their dream. Conclusion: Dreaming is quite common during IVA for short surgical procedure, more so following ketamine than propofol anaesthesia.
背景:麻醉期间做梦是一种常见现象。吸入剂和静脉注射剂(IVA),如异丙酚和氯胺酮,都能使人做梦。但也有一些担忧,比如患者的意识、梦境和其他可能与体外注射有关的不良影响。我们进行了这项研究,以量化异丙酚或氯胺酮在IVA期间做梦的发生率。方法:69例年龄在18 ~ 60岁的患者在IVA下进行5 ~ 25分钟的短时间手术,随机分为两组:异丙酚组和氯胺酮组。所有患者均静脉注射咪达唑仑和芬太尼。然后,异丙酚组给予异丙酚,氯胺酮组给予氯胺酮诱导和维持麻醉。手术结束后,当患者完全从麻醉中恢复过来时,对患者进行了关于梦的发生和他们回忆梦的能力的访谈。结果:异丙酚组35例,氯胺酮组34例。氯胺酮组麻醉期间做梦发生率为23例(67.65%),异丙酚组为7例(20%)(p < 0.001)。在做梦者中,氯胺酮组的6名患者和异丙酚组的1名患者能够回忆起他们的梦。结论:短时间手术IVA过程中做梦是很常见的,氯胺酮麻醉比异丙酚麻醉更常见。
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引用次数: 0
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Medical Journal of Pokhara Academy of Health Sciences
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