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Other genetic and acquired cardiomyopathies 其他遗传性和获得性心肌病
Pub Date : 2015-03-01 DOI: 10.1093/med/9780198703341.003.0036
P. Nihoyannopoulos, P. Elliott, G. Captur
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited, progressive cardiomyopathy associated with high risk of ventricular tachycardia associated with right-sided structural disorders. More recent reports have shown that although the right ventricle (RV) is most often affected, the left ventricle (LV) is also commonly involved. This has led to the more recent term arrhythmogenic cardiomyopathy (AC). Men are more frequently affected than women and it is usually diagnosed between the second and fourth decade of life. The most common presentation is ventricular arrhythmia, specifically ventricular tachycardia originating from the RV with a characteristic left bundle-branch block (LBBB) morphology. ARVC is also an important cause of sudden death in individuals <30 years of age and has been found in up to 20% of sudden deaths in young individuals. Furthermore, ARVC is more common in athletes and disease expression is associated with high intensity exercise.
心律失常性右室心肌病(ARVC)是一种遗传性进行性心肌病,与右侧结构障碍相关的室性心动过速的高风险相关。最近的报道显示,虽然右心室(RV)最常受到影响,但左心室(LV)也常受到影响。这导致了最近的术语心律失常性心肌病(AC)。男性比女性更容易受到影响,通常在生命的第二个和第四个十年之间被诊断出来。最常见的表现是室性心律失常,特别是室性心动过速,起源于左心室,具有典型的左束支阻滞(LBBB)形态。ARVC也是30岁以下人群猝死的一个重要原因,高达20%的年轻人猝死是由ARVC引起的。此外,ARVC在运动员中更为常见,疾病表达与高强度运动有关。
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引用次数: 0
Conventional echocardiography—basic principles 常规超声心动图-基本原理
Pub Date : 2015-03-01 DOI: 10.1093/med/9780198703341.003.0001
A. Hagendorff
Echocardiography is an imaging technique that enables accurate assessment of cardiac structures and cardiac function. Conventional echocardiography involves different modalities—especially the M-mode, the 2D, and colour Doppler, as well as the pulsed-wave and continuous wave Doppler. The M-mode illustrates the reflections of a single sound beam plotted against time. 2D echocardiography enables the documentation of views, which represent characteristic sectional planes of the moving heart during one heart cycle. Colour Doppler echocardiography adds the information of blood flow to the 2D cineloop. Pulsed-wave Doppler is the acquisition of a local blood flow spectrum of a defined region represented by the dimension of the sample volume, whereas continuous wave Doppler displays the blood flow spectrum of all measured blood flow velocities along a straight line sound beam from its beginning to the end. The handling of the transducer has to be target-oriented, stable with respect to the imaging targets, and coordinated with respect to angle differences between the defined views to use all these modalities correctly to get optimal image quality of the cineloops and spectra. Thus, the focus of this chapter will be a mainly practically oriented description of scanning technique in transthoracic and transoesophageal echocardiography.
超声心动图是一种能够准确评估心脏结构和心脏功能的成像技术。传统的超声心动图包括不同的模式-特别是m模式,2D和彩色多普勒,以及脉冲波和连续波多普勒。m模式表示单个声束随时间的反射。二维超声心动图能够记录视图,它代表了一个心脏周期中运动心脏的特征切面。彩色多普勒超声心动图将血流信息添加到二维循环中。脉冲波多普勒采集的是由样本量的尺寸表示的限定区域的局部血流频谱,而连续波多普勒显示的是沿着一条直线声束从开始到结束的所有测量到的血流速度的血流频谱。换能器的处理必须以目标为导向,相对于成像目标稳定,并与定义视图之间的角度差异协调,以正确使用所有这些模态,以获得最佳的影带和光谱图像质量。因此,本章的重点将主要是对经胸和经食管超声心动图扫描技术的实际描述。
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引用次数: 0
Echocardiography and detection of coronary artery disease 超声心动图与冠状动脉疾病的检测
Pub Date : 2015-03-01 DOI: 10.1093/MED/9780198703341.003.0018
R. Sicari
Non-invasive imaging modalities play an important role in the evaluation and management of patients with known or suspected coronary heart disease (CAD). This chapter will describe how we should use echocardiography in acute and chronic CAD at rest and during stress. In patients with established or suspected CAD, echocardiography provides useful information on the status of global and segmental myocardial function, the presence of functional mitral regurgitation and potentially of other signs of myocardial ischaemia. Echocardiography can be used to identify complications such as severe ventricular failure, acute mitral regurgitation, papillary muscle rupture, wall rupture, left ventricular (LV) thrombus, and cardiac tamponade. Inducible ischaemia is typically evaluated by stress echocardiography and will also be discussed in this chapter.
无创成像技术在评估和治疗已知或疑似冠心病(CAD)患者中发挥着重要作用。本章将描述我们应该如何使用超声心动图在急性和慢性冠心病在休息和压力。对于已确诊或疑似冠心病的患者,超声心动图可提供有关整体和节段心肌功能状态、功能性二尖瓣反流的存在以及潜在的其他心肌缺血迹象的有用信息。超声心动图可用于识别严重心衰、急性二尖瓣反流、乳头肌破裂、心壁破裂、左室血栓和心包填塞等并发症。诱导性缺血通常通过应激超声心动图进行评估,本章也将对此进行讨论。
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引用次数: 0
Aortic valve stenosis 主动脉瓣狭窄
Pub Date : 2015-03-01 DOI: 10.1093/med/9780198703341.003.0010
H. Baumgartner, E. Donal, S. Orwat, A. Schmermund, R. Rosenhek, D. Maintz
Aortic valve stenosis (AS) is the most prevalent valvular heart disease and is increasingly diagnosed in high-income countries due to an ageing population but also to more widely available diagnostic tools. The prevalence of AS is estimated at ~0.5% in the general population, ~2–3% in the population over 65 years old. This disease starts with mild fibrosis and calcification and thickening of the aortic valve leaflets without obstruction of blood flow, which is termed aortic sclerosis, and evolves over the years to severe calcification with impaired leaflet mobility and significant obstruction to blood flow, i.e. AS. The clinical presentation includes the spectrum from asymptomatic patients with different grades (mild, moderate, severe) of AS severity to symptomatic patients with severe AS who may present with preserved or already depressed left ventricular (LV) function and/or reduced transvalvular flow. Accurate assessment of the AS anatomic and haemodynamic severity as well as the extent of cardiac damage associated with AS are crucial for the therapeutic management of patients with AS. Doppler-echocardiography is the method of choice providing a comprehensive non-invasive diagnostic work-up of these patients.
主动脉瓣狭窄(AS)是最常见的瓣膜性心脏病,由于人口老龄化以及更广泛的诊断工具,在高收入国家越来越多地被诊断出来。AS的患病率估计在一般人群中约为0.5%,在65岁以上人群中约为2-3%。这种疾病开始时表现为主动脉瓣小叶轻度纤维化、钙化和增厚,血流不受阻,称为主动脉硬化,随着时间的推移发展为严重钙化,小叶活动性受损,血流明显受阻,即AS。临床表现包括从无症状的不同程度(轻度、中度、重度)AS严重程度的患者到有症状的严重AS患者,这些患者可能表现为左心室(LV)功能保留或已经下降和/或经瓣血流减少。准确评估AS的解剖学和血流动力学严重程度以及与AS相关的心脏损伤程度对于AS患者的治疗管理至关重要。多普勒超声心动图是为这些患者提供全面的无创诊断检查的首选方法。
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引用次数: 0
MDCT and detection of coronary artery disease MDCT与冠状动脉疾病的检测
Pub Date : 2015-03-01 DOI: 10.1093/med/9780198703341.003.0020
S. Achenbach
After the first introduction of CT angiography (CTA) in 1992, further technological advances, such as more powerful X-ray tubes, faster gantry rotation times, multiple parallel detector rings and decreased slice thickness led to progressively better and more stable image quality for visualization of the coronary arteries. Today, multidetector-row CT (MDCT) with gantry rotation times up to 240 milliseconds, a temporal resolution of up to 75 milliseconds, coverage in z-direction of up to 16 cm per rotation, and almost isotropic spatial resolution of as little as 0.4 mm allow for high-resolution, accurate imaging of the coronary artery wall and lumen. The quantification of calcified coronary atherosclerotic plaque burden (‘calcium score’) using native scans and the additional detection of non-calcified plaque and luminal narrowing through contrast-enhanced image acquisition (‘coronary CTA’) have established themselves as routine techniques in clinical practice which can be used not in all, but in many patients.
自1992年首次引入CT血管造影(CTA)以来,进一步的技术进步,如更强大的x射线管,更快的龙门旋转时间,多个平行检测器环和减少的切片厚度,使冠状动脉可视化的图像质量逐渐更好和更稳定。如今,多排探测器CT (MDCT)的龙门旋转时间可达240毫秒,时间分辨率可达75毫秒,z方向上每旋转可达16厘米,几乎各向同性的空间分辨率仅为0.4毫米,可以实现冠状动脉壁和管腔的高分辨率、精确成像。钙化冠状动脉粥样硬化斑块负荷的量化(“钙评分”)使用原生扫描和通过对比增强图像采集(“冠状动脉CTA”)额外检测非钙化斑块和管腔狭窄,已经成为临床实践中的常规技术,虽然不能用于所有患者,但可以用于许多患者。
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引用次数: 0
New developments in echocardiography/Advanced echocardiography 超声心动图的新发展/高级超声心动图
Pub Date : 2015-03-01 DOI: 10.1093/MED/9780198703341.003.0005
S. Gianstefani, J. Voigt, M. Monaghan
Despite the fact that three-dimensional echocardiography (3DE) has been available for many years, its utilization on a routine clinical basis has been rather limited. However, recent improvements in image quality, semi-automated quantification, better workflow, and other developments such as fusion imaging, have now accelerated the integration of 3D imaging into routine echo practice. In this chapter, we have reviewed the standard and well established applications of the technique such as volumetric chamber analysis and 3D evaluation of valvular pathology, as well as highlighting some of the exciting new developments such as the use of artificial intelligence and photo-realistic visualization. these newer techniques will undoubtedly help ensure that 3D echocardiography plays a pivotal role in contemporary cardiac imaging leading and cutting edge patient care.
尽管三维超声心动图(3DE)已经问世多年,但其在常规临床基础上的应用却相当有限。然而,最近在图像质量、半自动化量化、更好的工作流程和其他发展(如融合成像)方面的改进,现在已经加速了3D成像与常规回声实践的整合。在本章中,我们回顾了该技术的标准和成熟的应用,如容积室分析和瓣膜病理学的3D评估,并强调了一些令人兴奋的新发展,如人工智能和逼真可视化的使用。这些新技术无疑将有助于确保3D超声心动图在当代心脏成像领先和前沿患者护理中发挥关键作用。
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引用次数: 1
Dilated cardiomyopathy 扩张型心肌病
Pub Date : 1900-01-01 DOI: 10.1093/med/9780198849353.003.0045
U. Tayal, S. Prasad, T. Germans, A. V. van Rossum
Dilated cardiomyopathy (DCM) is characterized by enlargement of the heart with associated reduced left ventricular function. From an imaging perspective, important requirements are to exclude other pathologies, assess disease severity, guide therapeutic management, and identify complications. Establishing the imaging diagnosis of DCM is key to guiding the management of DCM. In this chapter we discuss how to use imaging to make an accurate diagnosis of DCM, and review how to exclude coronary artery disease (CAD) and valvular disease as these are two important differentials with differing management strategies. We then review the diagnostic and prognostic capabilities of echocardiography, cardiovascular magnetic resonance imaging (CMR) and nuclear techniques including single-photon emission computed tomography (SPECT) and positron emission tomography (PET) in DCM, with a focus on where imaging can identify particular causes of DCM.
扩张型心肌病(DCM)的特征是心脏增大并伴有左心室功能降低。从影像学角度来看,重要的要求是排除其他病理,评估疾病严重程度,指导治疗管理,识别并发症。建立DCM的影像学诊断是指导DCM治疗的关键。在本章中,我们讨论了如何使用影像学来准确诊断DCM,并回顾了如何排除冠状动脉疾病(CAD)和瓣膜疾病,因为这是两个重要的区别,不同的治疗策略。然后,我们回顾了超声心动图、心血管磁共振成像(CMR)和包括单光子发射计算机断层扫描(SPECT)和正电子发射断层扫描(PET)在内的核技术在DCM中的诊断和预后能力,重点是成像可以识别DCM的特定原因。
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引用次数: 0
Endocarditis 心内膜炎
Pub Date : 1900-01-01 DOI: 10.1093/med/9780198849353.003.0020
D. Muñoz, Á. M. del Castillo
Cardiac imaging is the cornerstone in the diagnosis of endocarditis. It plays a key role in the confirmation of the diagnosis, location, and extension of the disease, as well as on the evaluation of associated lesions that directly impact treatment options. Echocardiography, both transthoracic and transoesophageal, are the main tools in the diagnostic process. However, alternative imaging techniques have emerged to compensate some of their pitfalls. In this chapter, we review the potential findings as well as the advantages and limitations of each technique. A correct understanding of the information they can provide is essential both for the clinical cardiologist and the specialist in cardiac imaging.
心脏影像学是心内膜炎诊断的基础。它在确认疾病的诊断、定位和扩展以及评估直接影响治疗方案的相关病变方面发挥关键作用。超声心动图,无论是经胸还是经食管,都是诊断过程中的主要工具。然而,替代成像技术的出现弥补了它们的一些缺陷。在本章中,我们回顾了每种技术的潜在发现以及优点和局限性。对于临床心脏病专家和心脏成像专家来说,正确理解它们所能提供的信息是至关重要的。
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引用次数: 0
CMR—basic principles CMR-basic原则
Pub Date : 1900-01-01 DOI: 10.1093/med/9780198849353.003.0004
J. Bogaert, R. Symons, Jeremy T. Wright
Cardiac magnetic resonance imaging (CMR) has rapidly evolved to become the modality of choice in the evaluation of a wide spectrum of cardiovascular disorders. This is mostly related to its multiparametric approach where the different features such as morphology (including deep tissue characterization), function, perfusion can be non-invasively studied using a series of (different) pulse sequences. Therefore, CMR may provide a ‘one stop shop’ approach to cardiac patients offering a complete cardiac evaluation by a single modality without the use of ionizing radiation. However, to maximize its clinical use, not all pulse sequences should be used in every patient. Moreover, minimizing time spent in the magnetic resonance imaging (MRI) machine is desirable in critically ill, unstable patients. Therefore, experienced cardiac imagers from radiology and cardiology should be present to provide on-site real-time assessment of the images and to determine which pulse sequences are necessary each patient. In this fashion, a complete CMR exam should be obtainable in less than 30 minutes for the vast majority of patients. The aim of this chapter is to describe the physics and practical aspects of CMR and then explore the available pulse sequences, so that the clinical utility of CMR can be maximized.
心脏磁共振成像(CMR)已迅速发展成为评估广泛心血管疾病的首选方式。这主要与它的多参数方法有关,其中不同的特征,如形态(包括深层组织特征),功能,灌注可以使用一系列(不同的)脉冲序列进行无创研究。因此,CMR可以为心脏病患者提供“一站式”方法,通过单一模式提供完整的心脏评估,而无需使用电离辐射。然而,为了最大限度地提高其临床应用,并不是所有的脉冲序列都应该用于每个病人。此外,在危重、不稳定的患者中,尽量减少在磁共振成像(MRI)机上花费的时间是可取的。因此,来自放射科和心脏病学的经验丰富的心脏成像仪应该在场,对图像进行现场实时评估,并确定每个患者需要哪些脉冲序列。在这种情况下,对绝大多数患者来说,完整的CMR检查应在30分钟内完成。本章的目的是描述CMR的物理和实际方面,然后探索可用的脉冲序列,以便CMR的临床应用可以最大化。
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引用次数: 0
Cardiac CT—basic principles 心脏ct -基本原理
Pub Date : 1900-01-01 DOI: 10.1093/med/9780198849353.003.0003
G. Pontone, Filippo Cademartiri
Computed tomography (CT) was introduced for clinical diagnostic radiology in 1971, and it was used as neuro and body scanner for about 20 years. Spatial and temporal resolution required to evaluate a dynamic structure such as the heart was not sufficient until 1998. Thanks to the technical developments in CT technology over the past 20 years cardiac CT (CCT) developed from an investigative tool into an established clinical tool primarily used as non-invasive clinical diagnostic test for coronary artery imaging. The key technical development occurred in the late 1990s with the introduction of multidetector CT (4 slices) scanners able to synchronize image acquisition and reconstruction with an electrocardiographic (ECG) track. However, 4-slice and also the following 16-slice CT technology had technical limitations, such as limited coverage and temporal resolution, but which allowed diagnostic image quality in selected patients with low and stable heart rate. Moreover, relatively high radiation exposure was required to obtain clinically valid image quality. For this reason, different technical strategies were developed in the following years and advances were also provided in the field of reconstruction algorithm with the introduction of iterative algorithms that allowed an image noise reduction and in the field of tissue characterization with the use of dual-energy CT. All these advances allowed CCT to become a pivotal tool in the cardiology daily practice to image the coronary arteries and beyond.
计算机断层扫描(CT)于1971年被引入临床诊断放射学,并被用作神经和身体扫描仪约20年。直到1998年,评估像心脏这样的动态结构所需的空间和时间分辨率还不够。由于过去20年来CT技术的发展,心脏CT (CCT)从一种调查工具发展成为一种成熟的临床工具,主要用于冠状动脉成像的无创临床诊断测试。关键的技术发展发生在20世纪90年代末,随着多探测器CT(4片)扫描仪的引入,能够与心电图(ECG)轨迹同步图像采集和重建。然而,4层及随后的16层CT技术存在技术局限性,如有限的覆盖范围和时间分辨率,但可以在选定的心率低且稳定的患者中提供诊断图像质量。此外,为了获得临床有效的图像质量,需要相对较高的辐射暴露。因此,在接下来的几年里,不同的技术策略得到了发展,并且在重建算法领域也取得了进展,引入了允许图像降噪的迭代算法,并在使用双能CT的组织表征领域取得了进展。所有这些进步使CCT成为心脏病学日常实践中成像冠状动脉及其他部位的关键工具。
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引用次数: 0
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The ESC Textbook of Cardiovascular Imaging
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