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2023 Systems and Information Engineering Design Symposium (SIEDS)最新文献

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Control and Coordination for Swarm of UAVs Under Multi-Predator Attack 多掠食者攻击下无人机群的控制与协调
Pub Date : 2023-04-27 DOI: 10.1109/SIEDS58326.2023.10137788
Md. Muzakkir Quamar, S. Elferik
This paper presents the implementation of a cooperative prey hunting strategy for a swarm of unmanned aerial vehicles (UAVs) inspired by the collective behavior of fish and predators. The swarm of UAVs are modelled using diffusion and adaptation algorithms, which enable self-organization and create mobile adaptive networks. Nodes in the mobile adaptive networks interact with each other locally to solve issues of distributed processing and inference. The predator motion is modelled using a state transition model. The study provides insights into the dynamic network structures that arise during interactions between a swarm of fish and predators. The dynamic model of the swarm of fish and predators are modeled using the unicycle model on a coplanar surface. A Lyapunov-based Backstepping controller is designed to ensure that the UAVs track their trajectories accurately. From the simulation results, it can be observed that both the swarm UAVs and the predator successfully tracks the designed navigation path while foraging, evading, and attacking, mimicking the air combat scenario.
本文提出了一种受鱼类和捕食者集体行为启发的无人机群协同捕食策略的实现方法。使用扩散和自适应算法对无人机群进行建模,从而实现自组织并创建移动自适应网络。移动自适应网络中节点之间的局部交互解决了分布式处理和推理问题。捕食者的运动是用状态转移模型来建模的。这项研究为一群鱼和捕食者之间的互动过程中产生的动态网络结构提供了见解。采用共面单轮模型建立了鱼群和捕食者的动态模型。设计了一种基于lyapunov的反步控制器,以保证无人机的轨迹跟踪精度。从仿真结果可以看出,集群无人机和捕食者在觅食、躲避和攻击过程中都成功地遵循了设计的导航路径,模拟了空战场景。
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引用次数: 0
Faculty Complement Gap Analysis: A Case Study in a State University in the Philippines 教师补足差距分析:以菲律宾一所州立大学为例
Pub Date : 2023-04-27 DOI: 10.1109/SIEDS58326.2023.10137771
Pee Jay N. Gealone, Ramon Gian A. Bron, Rogelyn P. Samar, J. Barajas, Amelia A. Dorosan
In a state university, being mandated to provide education to as many students as possible, one of the main administrative challenges is the optimal and objective allocation of limited resources in hiring and assigning faculty to improve academic productivity. To aid administrators in this challenge, this work introduces a method in conducting analysis to determine faculty gap and the process of allocation of available faculty items for each program in the university. Factors considered in this analysis include the number of existing and projected students, curriculum, and other regulations that affect faculty workload, such as institutional, local, and national standards, that may have set the ideal faculty-student ratio and the amount of workload that each faculty can carry based on their respective specializations. This work presents a systematic process of analysis which is divided into the following parts: (i) analysis of existing curriculum; (ii) analysis of student population and future program demand; (iii) identifications of regulations that affect faculty workload; and (iv) analysis of existing faculty profile and faculty gap per program of the university. The study also introduces the concept of using a Faculty Complement Index (FCI) to rank the programs based on their level of faculty gap as an aid in achieving optimal faculty allocation. This work considers the situation of a state university in the Philippines with 152 academic programs, 630 faculty, and 28,403 students. The result of the analysis shows that a total of 293 faculty are needed, and the gaps are ranked using the FCI of each program or department.
在一所州立大学,被要求为尽可能多的学生提供教育,主要的行政挑战之一是在招聘和分配教师以提高学术生产力方面优化和客观地分配有限的资源。为了帮助管理人员应对这一挑战,本工作介绍了一种进行分析的方法,以确定教师差距,并为大学的每个项目分配可用的教师项目。该分析中考虑的因素包括现有和预计的学生数量、课程和其他影响教师工作量的规定,如机构、地方和国家标准,这些标准可能已经设定了理想的师生比例和每个教师可以根据各自的专业承担的工作量。这项工作呈现了一个系统的分析过程,分为以下几个部分:(i)现有课程的分析;(ii)学生人数及未来课程需求分析;(iii)确定影响教师工作量的规定;(四)分析现有的师资队伍和各专业的师资差距。该研究还引入了使用教师补充指数(FCI)的概念,根据教师差距水平对项目进行排名,以帮助实现最佳的教师分配。这项工作考虑了菲律宾一所州立大学的情况,该大学有152个学术项目,630名教师和28,403名学生。分析结果表明,总共需要293名教师,并使用每个项目或部门的FCI对差距进行排名。
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引用次数: 0
Tissue Classification Using RNA-Seq Transcriptomics with Distribution Analysis and SVM Models* 基于分布分析和SVM模型的RNA-Seq转录组学组织分类*
Pub Date : 2023-04-27 DOI: 10.1109/SIEDS58326.2023.10137900
Dominick DeCanio, Minah Kim, Samuel Haddox, G. Guadagni
The human body generates more proteins than it has genes that code for proteins. The diversity of proteins stems from the alternative ways in which RNA can be spliced and reassembled. Each alternative version of RNA produces a different protein, providing a way for our bodies to produce a wide range of proteins with a single gene. Some alternative RNA transcripts, however, have splicing errors and produce faulty proteins involved in genetic diseases. Understanding splicing patterns and profiles has wide implications for our understanding of healthy and diseased tissue states. Currently little is known regarding the splicing profiles of healthy tissue which vary across individuals and within individuals by tissue type. Therefore, this project explored the use of RNA splicing data from the first chromosome to predict the tissue type of non-cancerous samples using distribution analysis and supervised learning methods. The Kolmogorov-Smirnov test was used to classify the samples based on empirical cumulative distribution functions and was not able to reliably distinguish between tissue types. Our SVM model was run using both the quantity of splice junctions observed and their presence, and had a high prediction accuracy for both data sets. The performance between the two SVM model outcomes were not significantly different. Overall, the findings suggest the utility of using splice junction data in biological classification and sets the foundation for future work of mapping splicing patterns with phenotype.
人体产生的蛋白质比编码蛋白质的基因要多。蛋白质的多样性源于RNA可以被剪接和重组的不同方式。RNA的每一种变体都会产生一种不同的蛋白质,为我们的身体提供了一种用单一基因产生多种蛋白质的方法。然而,一些替代的RNA转录物有剪接错误,产生与遗传疾病有关的有缺陷的蛋白质。了解剪接模式和概况对我们理解健康和患病组织状态具有广泛的意义。目前,人们对健康组织的剪接谱知之甚少,这种剪接谱在个体之间和个体内部因组织类型而异。因此,本项目探索利用来自第一条染色体的RNA剪接数据,利用分布分析和监督学习方法来预测非癌样本的组织类型。采用基于经验累积分布函数的Kolmogorov-Smirnov检验对样本进行分类,不能可靠地区分组织类型。我们的支持向量机模型使用观察到的剪接的数量和它们的存在来运行,并且对两个数据集都有很高的预测精度。两种SVM模型结果的性能无显著差异。总的来说,这些发现表明了在生物学分类中使用剪接连接数据的效用,并为未来的剪接模式与表型的映射工作奠定了基础。
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引用次数: 0
Designing a Dashboard to Streamline Pediatric Heart Transplant Decision Making 设计一个简化儿科心脏移植决策的仪表板
Pub Date : 2023-04-27 DOI: 10.1109/SIEDS58326.2023.10137887
Connor Hyldahl, Olivia Kaczmarskyj, Joseph Laruffa, Allison Miller, Lilleth Snavely, Angela Wan, S. L. Riggs
Only 56% of eligible pediatric cardiac donor hearts are ultimately being accepted even though there are long waitlists for transplants and high waitlist mortality. A major contributing factor to low acceptance rates is due to the highly variable decision-making process of cardiologists who must determine the suitability of a potential transplant in an extremely short period of time. The current system, DonorNet, does not present information ideal for decision making under these conditions which has resulted in suboptimal decisions and cardiologists not being confident in their decisions. The goal of this project aims to adopt a user-centered systems design approach to develop a new DonorNet dashboard to better support the decision-making process for pediatric cardiologists. The design of an improved DonorNet dashboard was based on: (1) a literature review to understand the factors that influence practitioners in their decision-making process and identifying post hoc factors that are predictors of transplant success and (2) interviews by the research team with eight pediatric heart transplant practitioners to understand how end-users make decisions with DonorNet and identify common pain points. Based on this, we designed a dashboard using Figma based on our research findings that addressed identified pain points such as difficulty finding relevant data. We measured success with user satisfaction surveys before and after the redesign that included questions regarding how easy it was to find information and confidence in their decision. The expected results of the project will include a semi-functional dashboard that incorporates real data from databases containing information on patient and donor heart characteristics. Success of the interface will be evaluated through surveys assessing user satisfaction, time to arrive at a decision, and self-rated stress levels.
只有56%符合条件的儿童心脏供体最终被接受,尽管移植的等待名单很长,等待名单的死亡率很高。低接受率的一个主要因素是由于心脏病专家的决策过程高度可变,他们必须在极短的时间内确定潜在移植的适用性。目前的系统,DonorNet,在这些情况下不能提供理想的决策信息,这导致了次优决策和心脏病专家对他们的决策没有信心。该项目的目标是采用以用户为中心的系统设计方法来开发新的DonorNet仪表板,以更好地支持儿科心脏病专家的决策过程。改进的DonorNet仪表板的设计基于:(1)文献综述,以了解影响从业者决策过程的因素,并确定移植成功的预测因素;(2)研究团队对8名儿科心脏移植从业者的访谈,以了解最终用户如何使用DonorNet做出决策并识别常见痛点。基于此,我们使用Figma根据我们的研究结果设计了一个仪表板,解决了识别的痛点,如难以找到相关数据。我们通过重新设计之前和之后的用户满意度调查来衡量成功,其中包括查找信息的难易程度和对用户决策的信心。该项目的预期结果将包括一个半功能的仪表盘,该仪表盘结合了包含患者和捐赠者心脏特征信息的数据库中的真实数据。界面的成功将通过调查来评估用户满意度、做出决定的时间和自我评估的压力水平。
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引用次数: 0
Developing a Climbing Assistive Exoskeleton* 开发攀爬辅助外骨骼*
Pub Date : 2023-04-27 DOI: 10.1109/SIEDS58326.2023.10137830
Jared Rathbum, A. Sharky, Prathamesh Urunkar, Ashraf Saleem, P. Hazaveh
This paper presents a design of a climbing assistive exoskeleton (CAE) that reduces stress and strain on the fingers of a climber. Climbers routinely must support their entire body weight with their fingers. While human hands can accommodate climbing, experienced climbers are continuously testing the limits of their bodies, and hand injuries are both a frequent and severe occurrence. This device will help injured mountain climbers to continue training with reduced impact to their hand, and in turn increase climbing endurance and duration. Inexperienced climbers can also benefit from the device as they suffer from a lack of finger and hand muscle mass. This device will aid them in training safely and learn proper grips while developing their strength to be successful. The CAE is a glovelike device which can be slid on over the user's hand while climbing. The exoskeleton will have resistance bands going from the fingertips to the base of the hand, causing the hand to curl. This will create a constant passive force which will reduce the force normally directed through the pulleys and tendons while climbing. In the case of hand opening, the CAE has a motor that should assist the climber to overcome the passive force created by the bands. The glove is controlled through a microcontroller in real-time via feedback from electromyography sensors attached to the forearm of the climber. Our objective is to achieve a 20-40N reduction in force through the fingers while climbing per hand.
本文介绍了一种攀岩辅助外骨骼(CAE)的设计,它可以减少攀岩者手指上的压力和应变。登山者通常必须用手指支撑整个身体的重量。虽然人的手可以适应攀岩,但有经验的登山者不断地测试他们身体的极限,手部受伤是经常发生的,也是严重的。这个装置将帮助受伤的登山者继续训练,减少对他们的手的冲击,从而增加攀登耐力和持续时间。没有经验的登山者也可以从这个设备中受益,因为他们的手指和手部肌肉量不足。这个装置将帮助他们在安全训练和学习正确的握持,同时发展他们的力量是成功的。CAE是一种类似手套的装置,可以在攀爬时滑过使用者的手。外骨骼将有从指尖到手底的阻力带,导致手弯曲。这将产生一个恒定的被动力,这将减少攀爬时通常通过滑轮和肌腱引导的力。在手张开的情况下,CAE有一个马达,应该帮助登山者克服由手带产生的被动力。该手套通过附着在登山者前臂上的肌电传感器的反馈,通过微控制器实时控制。我们的目标是在每只手攀爬时,通过手指减少20-40牛的力。
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引用次数: 0
Methods for the Spatial Analysis of Invasive Species and Ecosystem Fragmentation at Conservation Sites in Malta Using Drones * 基于无人机的马耳他自然保护区入侵物种和生态系统破碎化空间分析方法*
Pub Date : 2023-04-27 DOI: 10.1109/SIEDS58326.2023.10137865
E. C. McConville, A. I. Oancea, E. M. Enright, T. Brown, J. Henriques
Managing environmental conservation sites on the island of Malta is challenging due in part to pressures from urbanization and disruptions from changing land use patterns. Understanding the spatial and temporal context of these challenges through data visualization techniques is an important tool for conserving these ecosystems. This paper describes a set of approaches using aerial imagery collected by drones in support of ecosystem management for specific sites managed by a non-profit, non-governmental environmental organization working in the Maltese islands. Drone images were first taken using automated flight patterns to create high-resolution orthomosaic images. Data collected through fieldwork was combined with the orthomosaics for spatial analysis using GIS tools. The primary focus of the GIS analysis was to use the orthomosaics for the identification of invasive and endangered species and to monitor coastal erosion. These methods help enable efficient, periodic data updates and mapping by the site managers. Additional benefits of the approach described in the paper include helping site managers gain insights into ecosystem fragments from urban expansion and establishing a baseline to analyze future change. The maps created can help improve public awareness of each site and more broadly promote environmental awareness of different conservation sites throughout the islands.
管理马耳他岛上的环境保护地点具有挑战性,部分原因是城市化的压力和土地利用模式变化带来的破坏。通过数据可视化技术了解这些挑战的时空背景是保护这些生态系统的重要工具。本文描述了一套方法,利用无人机收集的航空图像来支持由一个在马耳他群岛工作的非营利非政府环境组织管理的特定地点的生态系统管理。无人机图像首先使用自动飞行模式拍摄,以创建高分辨率的正交图像。通过实地调查收集的数据与使用GIS工具进行空间分析的正形图相结合。地理信息系统分析的主要重点是利用正地貌识别入侵和濒危物种,并监测海岸侵蚀。这些方法有助于站点管理员实现有效的、定期的数据更新和映射。论文中描述的方法的其他好处包括帮助站点管理者深入了解城市扩张带来的生态系统碎片,并建立基线来分析未来的变化。绘制的地图可以帮助提高公众对每个保护区的认识,并更广泛地提高对整个岛屿不同保护区的环保意识。
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引用次数: 0
Embodied AI for Financial Literacy Social Robots 金融知识社交机器人的嵌入人工智能
Pub Date : 2023-04-27 DOI: 10.1109/SIEDS58326.2023.10137791
Qinyuan Jiang, Lucas Zak, Shirley Leshem, Pulkit Rampa, Sophie Howle, Haley N. Green, Tariq Iqbal
Financial literacy is a critical field that prepares individuals to manage their money effectively and to become economically self-suffcient by making informed financial decisions. As artificial intelligence (AI) becomes more widespread across a variety of disciplines, including K-12 education, and more financial institutions move towards digitizing their services, the demand for AI systems in financial literacy education is growing. While many financial and educational institutions alike have implemented AI systems, there remains a need for a system geared toward teaching young students these important lessons and skills. To address this demand, we have created an AI system equipped with financial literacy lessons for grade school students. The system, which is embedded into a NAO robot, a humanoid robot designed for use within education, was evaluated on its performance in the classroom across multiple metrics, including its effcacy, its robustness and feasibility in the classroom, and the students’ enjoyment in using it. The results from the experiments suggest that the system did result in the retention of material, but did not do so at a significantly different level than the more traditional teaching method of a guided worksheet. However, the students did report higher levels of enjoyment in using the robot when compared to a worksheet. These results show promise for future uses of the system, as well as shed light on areas in which the system can be improved in the future.
金融知识是一个重要的领域,它使个人能够有效地管理他们的钱,并通过做出明智的财务决策而在经济上自给自足。随着人工智能(AI)在包括K-12教育在内的各个学科中的应用越来越广泛,以及越来越多的金融机构朝着数字化服务的方向发展,金融知识教育对AI系统的需求正在增长。虽然许多金融和教育机构都已经实施了人工智能系统,但仍然需要一个面向年轻学生传授这些重要课程和技能的系统。为了满足这一需求,我们创建了一个人工智能系统,为小学生提供金融知识课程。该系统被嵌入到NAO机器人(一种专为教育用途而设计的人形机器人)中,通过多种指标对其在课堂上的表现进行了评估,包括其有效性、在课堂上的稳健性和可行性,以及学生使用它的乐趣。实验结果表明,该系统确实导致了材料的保留,但与更传统的指导工作表教学方法相比,并没有显著不同的水平。然而,与使用工作表相比,学生们确实报告了使用机器人的更高水平的乐趣。这些结果显示了该系统未来使用的前景,也揭示了该系统未来可以改进的领域。
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引用次数: 1
A Robust Control Chart for Monitoring Reliability Systems 可靠性系统监控的鲁棒控制图
Pub Date : 2023-04-27 DOI: 10.1109/SIEDS58326.2023.10137918
Parisa Jahani Alamdari, Mohammad Mahdi Ahmadi
Control charts are one of the significant statistical control tools widely used to monitor processes. The system’s reliability is affected by failure processes during its lifetime. Monitoring the failure processes is a crucial issue in complex and repairable systems. To design accurate control charts for monitoring a reliability system, it is necessary to estimate the system parameters properly. Since the presence of outliers in sample data can highly affect the parameter estimation using a classic estimator, a robust estimator can estimate the parameters efficiently and close to the actual value in the presence of contamination. In this research, robust monitoring for reliability systems is designed. To estimate the distribution parameters, the robust method based on the M-estimator is used to estimate the time between failure distribution parameters from the Weibull distribution. Using simulation studies, the efficiency of the classic and robust estimators is compared based on the norm and MSE under different contamination scenarios. Then, the robust lower control limit is designed based on the simulated control limit and mathematical formulation methods. The results show that the robust control limits are close to the actual values in the absence or presence of outliers. However, the classic control limits are highly affected by the contamination and their values are far from the actual when there are shifts in the parameter.
控制图是一种重要的统计控制工具,广泛用于过程监控。系统的可靠性在其生命周期内受到故障过程的影响。在复杂的可修复系统中,监测故障过程是一个至关重要的问题。为了设计准确的控制图来监控可靠性系统,需要对系统参数进行适当的估计。由于样本数据中异常值的存在会严重影响使用经典估计器的参数估计,因此在存在污染的情况下,鲁棒估计器可以有效地估计参数并接近实际值。在本研究中,设计了可靠性系统的鲁棒监控。为了估计分布参数,采用基于m估计量的鲁棒方法从威布尔分布中估计故障分布参数的间隔时间。通过仿真研究,比较了经典估计器和鲁棒估计器在不同污染情况下的范数和均方误差的效率。然后,基于仿真控制下限和数学公式的方法,设计了鲁棒控制下限。结果表明,在没有或存在异常值的情况下,鲁棒控制极限接近实际值。然而,经典的控制极限受污染的影响较大,当参数发生变化时,其值与实际值相差较大。
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引用次数: 0
A Design Feasibility Investigation for a Pulmonary ePTFE Transcatheter Pediatric Heart Valve 肺脏ePTFE经导管儿童心脏瓣膜设计可行性研究
Pub Date : 2023-04-27 DOI: 10.1109/SIEDS58326.2023.10137819
Ryan M. Arul, McKaila K. Danajka, Emily C. Gray, Kendall P. Henretta, O. Pierrakos
The most replaced valve in the congenital heart defects population is the pulmonary valve. Current treatments require multiple invasive, open-heart surgeries to replace the pulmonary valve as the patient grows. Minimally-invasive procedures, such as transcatheter pulmonary valve replacement, circumvent open heart surgery, which benefits patients and physicians. ePTFE valves have gained prominence recently because they allow cardiothoracic pediatric surgeons to tailor the valve size to the patient. Clinical studies point to the high patency of ePTFE valves. Currently, there are no FDA-approved transcatheter valves made with ePTFE. The purpose of this paper is to offer a preliminary design feasibility investigation of developing a transcatheter ePTFE pulmonary valve. We used an existing FDA-approved Medtronic Ensemble II delivery system to test and evaluate the feasibility of fitting an ePTFE pediatric valve to this existing deployment system. The prototyping and testing goals were: (1) to evaluate stent expansion, (2) to explore anchoring mechanisms, (3) to collapse the stent with the ePTFE conduit down to a size that would fit into a catheter, and (4) to expand and deploy the ePTFE stent-conduit pulmonary valve. Testing revealed that ePTFE conduits with wall thicknesses of 1 mm and 0.5 mm did not collapse to a small enough diameter to fit in the sheath of the Medtronic Ensemble II delivery system. However, expansion of anchored stents showed that valves upheld circular cross-sections when deployed. For the valve to be widely distributed, the product must follow FDA and ISO 5840 standards to ensure appropriate performance. There remains considerable future work to deliver a well-functioning ePTFE transcatheter pulmonary heart valve solution for pediatric patients.
在先天性心脏缺陷人群中置换最多的瓣膜是肺动脉瓣。目前的治疗需要多次有创的心内直视手术,随着患者的成长来更换肺瓣膜。微创手术,如经导管肺瓣膜置换术,避免了心内直视手术,这对患者和医生都有好处。ePTFE瓣膜最近得到了重视,因为它们允许心胸儿科外科医生为患者量身定制瓣膜大小。临床研究表明ePTFE瓣膜具有较高的通畅度。目前,fda还没有批准使用ePTFE制造经导管瓣膜。本文的目的是为开发经导管ePTFE肺动脉瓣提供初步的设计可行性研究。我们使用现有的fda批准的美敦力集成II输送系统来测试和评估将ePTFE儿童瓣膜安装到现有部署系统的可行性。原型和测试的目标是:(1)评估支架的扩展,(2)探索锚定机制,(3)将ePTFE导管支架折叠到适合导管的尺寸,(4)扩展和部署ePTFE支架-导管肺动脉瓣。测试显示,壁厚分别为1毫米和0.5毫米的ePTFE导管没有塌陷到足够小的直径,无法装入美敦力Ensemble II输送系统的护套中。然而,锚定支架的膨胀表明,当部署时,阀门维持圆形截面。对于广泛分布的阀门,产品必须遵循FDA和ISO 5840标准,以确保适当的性能。为儿科患者提供功能良好的ePTFE经导管肺心脏瓣膜解决方案仍有大量的未来工作要做。
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引用次数: 0
Designing and Building a Deep Imaging Multi-Parametric Optical Coherence Tomography System for Disease Assessment 用于疾病评估的深度成像多参数光学相干层析成像系统的设计与构建
Pub Date : 2023-04-27 DOI: 10.1109/SIEDS58326.2023.10137789
Bruce Vagt, Matthew Foster, Richard L. Blackmon
Early cancer detection remains an important problem in healthcare today. Since the mid-1990s, Optical Coherence Tomography (OCT) has been explored as a cancer detection instrument. Previous studies have shown connections between tissue porosity, cell behavior, cell topology, and their relation to cancer and disease progression. Previous researchers have found that in a healthy cell, the pore size of the surrounding extracellular matrix (ECM) is homogenous. However, in a cancerous cell, heterogeneous pores appear. Additionally, as cancer progresses, pore size decreases. Herein, we propose a new method of improving cancer detection using OCT. In a study utilizing an artificial ECM, a connection between pore size and gold nanorod (GNR) diffusion was established such that smaller pores lead to less diffusion, and vice versa. Cell behavior is measured by cell motility, which refers to the rapid, in-place motions of intracellular parts that can be used to assess cell response to therapy, their surrounding environment, and potentially reveal premalignant behavior. Previous investigators have defined two metrics of cell movement, alpha, and motility, which correspond to signal auto-decorrelation and signal amplitude, respectively. Cell topology refers to the 3D structure and shape of cells and cell clusters, which has been shown to mutate in diseases such as cancer. By quantifying cell topology, cellular health can be examined. Techniques using OCT have also been used to monitor the response of diseased tissue to treatment. These studies have been largely independent of each other, and the need for a more holistic measuring system has been called for. This research aims to create a custom OCT system capable of obtaining these metrics simultaneously and with improved imaging depth and comparable resolution. Through an integration of a near-infrared (NIR) laser, interferometer, and LabVIEW control of the system, a new Deep-Imaging, Multi-Parameter OCT (DIMP-OCT) is being created. The system bodes a 4.6µm resolution and 5.4mm imaging depth. This is made possible by a 50-50 fiber optic beam splitter using a 1300nm wavelength laser with 160nm bandwidth, and 2048-pixel spectrometer with a 140kHz linerate. Here, we report the design of the system being built, the techniques used to build and test the hardware, and the approach to developing the graphical user interface. We also will report results from tests to assess DIMP-OCT subsystems.
早期癌症检测仍然是当今医疗保健中的一个重要问题。自20世纪90年代中期以来,光学相干断层扫描(OCT)作为一种癌症检测仪器被探索。先前的研究已经显示了组织孔隙度、细胞行为、细胞拓扑结构及其与癌症和疾病进展的关系之间的联系。先前的研究人员发现,在健康细胞中,周围细胞外基质(ECM)的孔径是均匀的。然而,在癌细胞中,出现了不均匀的毛孔。此外,随着癌症的发展,孔隙大小会减小。在此,我们提出了一种利用oct改进癌症检测的新方法。在一项利用人工ECM的研究中,我们建立了孔径与金纳米棒(GNR)扩散之间的联系,即孔径越小,扩散越少,反之亦然。细胞行为是通过细胞运动来测量的,细胞运动是指细胞内部分的快速、原位运动,可用于评估细胞对治疗的反应、周围环境,并可能揭示癌前行为。先前的研究者已经定义了细胞运动的两个指标,α和运动性,分别对应于信号的自相关和信号幅度。细胞拓扑是指细胞和细胞簇的三维结构和形状,已被证明在癌症等疾病中会发生突变。通过量化细胞拓扑结构,可以检查细胞健康状况。OCT技术也被用于监测病变组织对治疗的反应。这些研究在很大程度上是相互独立的,因此需要一个更全面的测量系统。本研究旨在创建一个定制的OCT系统,能够同时获得这些指标,并具有改进的成像深度和可比较的分辨率。通过集成近红外(NIR)激光器、干涉仪和系统的LabVIEW控制,一种新的深度成像、多参数OCT (dip -OCT)正在创建中。该系统的分辨率为4.6 μ m,成像深度为5.4mm。这是通过一个50-50光纤分束器实现的,该分束器使用1300nm波长的激光器,带宽为160nm, 2048像素光谱仪,带宽为140kHz。在这里,我们报告了正在构建的系统的设计,用于构建和测试硬件的技术,以及开发图形用户界面的方法。我们还将报告评估DIMP-OCT子系统的测试结果。
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2023 Systems and Information Engineering Design Symposium (SIEDS)
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