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Rudolf Virchow: Requiem for a Visionary 鲁道夫·魏尔肖:梦想家的安魂曲
Pub Date : 2020-06-30 DOI: 10.53902/cicmr.2021.01.000505
Julián Rondón Carvajal
Rudolf Virchow's scientific legacy to mankind is invaluable. His holistic view of disease allowed him to develop detailed experimental models based on the precepts of cell biology, which is why he is considered the forerunner of modern pathology. Many of his observations were transferred to the clinical setting and are still valid today in different areas of internal medicine. This biographical sketch highlights his main contributions to modern medical practice on the basis of his profound social sensitivity, including the founding of the first German anthropological society.
鲁道夫·维尔肖给人类留下的科学遗产是无价的。他对疾病的整体看法使他能够根据细胞生物学的规律建立详细的实验模型,这就是为什么他被认为是现代病理学的先驱。他的许多观察结果被转移到临床环境中,今天在内科的不同领域仍然有效。这个传记概要突出了他对现代医学实践的主要贡献,基于他深刻的社会敏感性,包括建立第一个德国人类学学会。
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引用次数: 2
Compassion: The Art of Medicine 同情心:医学的艺术
Pub Date : 1900-01-01 DOI: 10.53902/cicmr.2020.01.000501
M. Donohue
Compassion is necessary in clinical situations because they involve a medical response to suffering and carry respect, a desire to help, serve, and express solidarity. The use of the three “t's” to express compassion has been suggested: talk, take time, and touch (Talk or listen, Give time and Touch or caress). Compassion is part of humanization and involves affection, dedication, respect for the other and considering the person in their total integrity. Doctors and nurses should invite the family to participate in the health care of their relatives. In this act the values and virtues that make up the moral formation and that are taught or reinforced in the medical school emerge.
同情心在临床情况下是必要的,因为它涉及到对痛苦的医疗反应,并带有尊重、帮助、服务和表达团结的愿望。有人建议用三个“t”来表达同情:交谈、花时间和触摸(交谈或倾听、付出时间和触摸或爱抚)。同情是人性化的一部分,包括感情、奉献、对他人的尊重以及考虑到他人的完整。医生和护士应邀请家属参与其亲属的保健工作。在这个过程中,构成道德形成的价值观和美德在医学院被教授或强化。
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引用次数: 0
Correlation of Erythrocyte Distribution Width Values with Preeclampsia and Preeclampsia with Severity Criteria 红细胞分布宽度值与子痫前期及子痫前期严重程度的相关性
Pub Date : 1900-01-01 DOI: 10.53902/cicmr.2022.01.000516
E. A. Mendoza
Aim: To determine the correlation of the red cell distribution width values with pre-eclampsia and pre-eclampsia with severity criteria. Materials and methods: Cross-sectional, prospective study of patients who met the inclusion criteria in the period from August 2019 to August 2020. Statistical analysis was performed using Student's t test and Spearman's correlation to calculate the dependence between the non-parametric variables, the value of p<0.05 was considered statistically significant. Results: 9 patients with pre-eclampsia and 30 pre-eclampsia were obtained with severity criteria. There was no statistical difference when comparing the RDW of patients with pre-eclampsia and pre-eclampsia with severity criteria (p=0.226), in patients with systolic blood pressure values ≥160mmHg there was an increase in RDW levels (p=0.042) Objective: To determine the correlation of erythrocyte distribution width values with pre-eclampsia and pre-eclampsia with severity criteria. Conclusions: There is a significant relationship between increased RDW and systolic blood pressure values ≥160mmHg.
目的:探讨红细胞分布宽度值与子痫前期及子痫前期严重程度的相关性。材料与方法:对2019年8月至2020年8月符合纳入标准的患者进行横断面前瞻性研究。采用Student’st检验和Spearman相关进行统计分析,计算非参数变量之间的相关性,p<0.05为有统计学意义。结果:9例子痫前期,30例子痫前期符合严重度标准。子痫前期患者与子痫前期患者的RDW与严重度标准比较,差异无统计学意义(p=0.226),收缩压≥160mmHg患者的RDW水平升高(p=0.042)目的:探讨红细胞分布宽度值与子痫前期及子痫前期与严重度标准的相关性。结论:RDW升高与收缩压值≥160mmHg有显著关系。
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引用次数: 0
Diagnostic Performance of the Leuko-CRP Index and Procalcitonin in Patients with Suspected Sepsis who Come to the Emergency Room of the IESS Riobamba Hospital in the period July-December 2017 2017年7 - 12月IESS Riobamba医院急诊疑似脓毒症患者白细胞- crp指数及降钙素原的诊断价值
Pub Date : 1900-01-01 DOI: 10.53902/cicmr.2021.01.000507
H. Castillo
Introduction: Syndrome systemic inflammatory response (SIRS) is activated by the presence of any organic infection to, continuing evolves sepsis, septic shock, multiple organ failure and ends in death. Objective: Determine the utility leuco index/PCR as diagnostic early sepsis. Materials and Methods: Research has no experimental, of type descriptive, transverse and retrospective during the period July-December 2017, in patients with suspected bacterial sepsis attending IESS Riobamba Hospital emergency. It is utilize for diagnostic validity to the calculation of sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), likelihood ratio and ROC curves. Results: Se and videnctio as Qua r point of co ho rte of the leuco-PCR index a value of619.82 (AUC:0.85; IC-95%: 0.76-0.9 5; p<0.05) for a procalcitonin greater than or equal to 1ng/dl; while for a procalcitonin most or equal to 0.5ng/dl, an AUC: 0.8 2; CI-95 %; 0.71-0.9 2; p<0.05 ). Conclusion: The index leuco-PCR is useful in the diagnosis of sepsis, and alternative accesib him and inexpensive compared to procalcitonin.
系统性炎症反应(SIRS)由任何器质性感染激活,持续发展为败血症、感染性休克、多器官衰竭并最终死亡。目的:探讨白细胞计数/PCR在早期脓毒症诊断中的应用价值。材料与方法:2017年7月至12月,对IESS Riobamba医院急诊的疑似细菌性脓毒症患者进行无实验性、描述性、横向和回顾性研究。通过敏感性、特异性、阳性预测值(PPV)、阴性预测值(NPV)、似然比和ROC曲线的计算来评价诊断的有效性。结果:Se和vitio作为检测的标准点,其值为619.82 (AUC:0.85);Ic-95%: 0.76-0.9 5;P <0.05),降钙素原大于或等于1ng/dl;降钙素原≤0.5ng/dl, AUC为0.8;ci - 95 %;0.71 - -0.9 2;p < 0.05)。结论:与降钙素原相比,荧光定量pcr在脓毒症的诊断中具有较好的应用价值。
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引用次数: 0
CH50 Activity and its Relationship to Antimüllerian Hormone in Patients with Infertility 不孕症患者CH50活性及其与抗<s:1>勒氏杆菌激素的关系
Pub Date : 1900-01-01 DOI: 10.53902/cicmr.2021.01.000513
José Manuel Lozano Sánchez
Objective: To study the importance of immunological screening (CH50, C3, C4) to determine the correlation between the ovarian reserve and complement pathway. Design: A cross-sectional multivariate study. Setting: Single tertiary referral center. Patients: 40 Women with infertility diagnosis who underwent In Vitro Fertilization (IVF). Intervention(s): Basal blood samples collected to measure complement pathway and antimüllerian hormone. Main Outcome Measure(s): To correlate complement pathways (CH50 levels) with AMH. Results: The complement system and ovarian reserve were studied in 40 women aged from 28-48 years (mean=37.87 years), finding the values of CH50 65-268 CAE (mean=153.2 CAE), C3 13.9- 183mg/dl (mean=128.52mg/dl), C4 11.5-106mg/dl (mean=29.86mg/dl), AMH 0.10-3.9ng/dl (mean=1.32ng/dl). A multivariate analysis comparison was also conducted yielding significant results: negative correlation between AMH and age (Spearman correlation -0.6; P=0.001), as well as between AMH and CH50 (Spearman correlation -0.4; P=0.0129). Conclusion: High CH50 levels are correlated with an AMH decrease and it could be accordingly associated with age-related chronic inflammation. Capsule: High levels of CH50 are correlated with a decrease in AMH levels and could also be considered as a marker of poor response in IVF cycles.
目的:探讨免疫筛查(CH50, C3, C4)对确定卵巢储备与补体通路的相关性的重要性。设计:横断面多变量研究。环境:单一三级转诊中心。患者:40例经体外受精诊断为不孕症的妇女。干预措施:收集基础血液样本,测量补体途径和抗勒氏杆菌激素。主要观察指标:补体通路(CH50水平)与AMH的相关性。结果:40例年龄28 ~ 48岁(平均37.87岁)女性的补体系统和卵巢储备的CH50 CAE值为65 ~ 268(平均153.2 CAE), C3 CAE值为13.9 ~ 183mg/dl(平均128.52mg/dl), C4 CAE值为11.5 ~ 106mg/dl(平均29.86mg/dl), AMH CAE值为0.1 ~ 3.9ng/dl(平均1.32ng/dl)。多因素分析比较也得出了显著的结果:AMH与年龄呈负相关(Spearman相关-0.6;P=0.001),以及AMH与CH50之间(Spearman相关性为-0.4;P = 0.0129)。结论:高CH50水平与AMH降低相关,并与年龄相关性慢性炎症相关。胶囊:高水平的CH50与AMH水平的降低相关,也可以被认为是IVF周期反应不良的标志。
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引用次数: 0
Outcome of Patients with ST-T Changes in Non STSegment Elevation Myocardial Infarction 非st段抬高型心肌梗死患者ST-T改变的预后
Pub Date : 1900-01-01 DOI: 10.53902/cicmr.2021.01.000504
Mohammad Arifur Rahman
This article discusses the fundamental characteristics of measured glucose levels and predicted glycated hemoglobin A1c (HbA1c) values among three sets of collected data, measured finger-piercing and continuous glucose monitoring (CGM) sensor device collected glucose levels at 15-minute (15-min) and 5-minute (5-min) intervals. The average glucose (in milligram per deciliter-mg/dL) is listed below: Finger glucose: 109 mg/dL (100%) Sensor at 15-min: 120 mg/dL (109%) Sensor at 5-min: 117 mg/dL (107%) Using candlestick chart, the comparison of average glucoses during this period between two sensor glucose (mg/dL) data (15-min/5-min) are as follows: Open glucose: 108/111 Close glucose: 115/115 Maximum (max) glucose: 170 /175 Minimum (min) glucose: 85/83 Average glucose: 120/117 Additional analysis of time above range (TAR)≥140 mg/dL for hyperglycemia, time within the range (TIR) from 70-140 mg/dL for normal, time below range (TBR)≤70 mg/dL for hypoglycemia based on two sensor candlesticks revealing the following information in a specific format of TAR%/ TIR%/TBR%. 15-min:18.3%, 80.5%, 1.2% 5-min: 17.0%, 81.9%, 1.1% By evaluating the results of the TIR analysis, the 5-min glucose levels appear to be marginally healthier (1.4%) than the 15-min ones. During the coronavirus pandemic (COVID 19) quarantine period, the author lived a rather unique lifestyle which is extremely calm with regular routines, such as eating home-cooked meals and exercising on a regular basis. As a result, his HbA1c has decreased from 6.6% to 6.3% with an average A1c of 6.4% without taking any diabetes medications. However, these three different measurement methods still provide three different sets of glucoses levels which are within a 10% margin of differences, while the HbA1c values are particularly close to each other between the finger-piercing and CGM 15-min.
本文讨论了三组收集数据中测量的葡萄糖水平和预测的糖化血红蛋白(HbA1c)值的基本特征,测量的手指穿刺和连续血糖监测(CGM)传感器装置每隔15分钟(15分钟)和5分钟(5分钟)采集葡萄糖水平。平均葡萄糖(毫克/分升-毫克/分升)如下:手指葡萄糖:109毫克/分升(100%)传感器15分钟:120毫克/分升(109%)传感器5分钟:117毫克/分升(107%)使用烛台图,这段时间内两个传感器葡萄糖(mg/分升)数据(15分钟/5分钟)的平均葡萄糖比较如下:开放葡萄糖:108/111关闭葡萄糖:115/115最大(max)葡萄糖:170 /175最小(min)葡萄糖:85/83平均葡萄糖:120/117根据两个传感器烛台以特定格式显示以下信息:高血糖高于范围(TAR)≥140 mg/dL,正常血糖在范围(TIR) 70-140 mg/dL,低血糖低于范围(TBR)≤70 mg/dL。通过评估TIR分析的结果,5 min的血糖水平似乎比15 min的血糖水平略健康(1.4%)。在新冠肺炎疫情隔离期间,作者过着一种非常独特的生活方式,非常平静,有规律的日常生活,比如吃家常饭菜,定期锻炼。结果,在没有服用任何糖尿病药物的情况下,他的HbA1c从6.6%降至6.3%,平均A1c为6.4%。然而,这三种不同的测量方法仍然提供了三组不同的血糖水平,这些血糖水平在10%的差异范围内,而HbA1c值在穿指穿刺和CGM 15分钟之间特别接近。
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引用次数: 0
Criteria for Rational Use of Antibiotics in Over Aggregated Bacterial Infection in Covid-19 Covid-19超聚集性细菌感染合理使用抗生素标准
Pub Date : 1900-01-01 DOI: 10.53902/cicmr.2021.01.000514
Vásquez Cubas Humberto
The use of antibacterials, in almost all COVID cases that require hospitalization, has been widespread throughout the planet despite being a viral infection verified by molecular biology and tomographic images characteristic of bilateral atypical pneumonia. The WHO recommended using empirical antibiotic therapy "against all the most frequent pathogens" in cases of COVID pneumonia that require hospitalization. This abuse will have dire consequences on the bacterial flora due to selection pressure, mainly of extended spectrum beta-lactamase-producing Enterobacteriaceae, Pseudomonas aeruginosa, Acinetobacter baumanii and other multi-resistant bacteria. Some criteria or guidelines are proposed to decide or not the administration of antibacterials to cases of COVID with respiratory failure and need for hospitalization.
在几乎所有需要住院治疗的COVID病例中,抗生素的使用在全球范围内都很普遍,尽管这是一种经分子生物学和双侧非典型肺炎特征的断层扫描图像证实的病毒感染。世卫组织建议,在需要住院治疗的COVID - 19肺炎病例中,使用经验性抗生素治疗“针对所有最常见的病原体”。由于选择压力,这种滥用将对菌群造成严重后果,主要是产生广谱β -内酰胺酶的肠杆菌科、铜绿假单胞菌、鲍曼不动杆菌等多重耐药菌。提出了一些标准或指南,以决定是否对呼吸衰竭和需要住院治疗的COVID患者使用抗菌药物。
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引用次数: 0
Effect of Short-Term Practice of Breathing Exercises on the Breathing Capacity in Children 短期呼吸练习对儿童呼吸能力的影响
Pub Date : 1900-01-01 DOI: 10.53902/cicmr.2021.01.000508
H. J. Costa
The breathing mechanism has existed since our birth and accompanies us throughout life. Breathing is an important function in the regulatory process of numerous body functions, its optimization can bring many health benefits. However, many children are unaware of the mechanisms of breathing, namely abdominal or diaphragmatic breathing, and in addition to this, many breathe normally through their mouths. The present study aimed to verify the influence of a short-term breathing exercise program on children's breathing capacity. Twenty-one children aged between 8 and 10 years were selected, from this selection two groups were formed, the control group (CG) with 10 children and the experimental group (EG) with 11. Through a spirometric test, an assessment of breathing capacity (ABC) was carried out for both groups. The GE participated in a program of breathing exercises (BEP) lasting 15 to 20 minutes for 5 weeks. Then, the ABC was performed again for both groups. The results demonstrate a significant increase in the values (p<0.027) of the forced vital capacity (FVC) of the EG, thus suggesting that the application of a BEP promotes the breathing capacity of school-aged children. Further studies should be performed with larger samples and with a longer protocol.
呼吸机制自我们出生以来就存在,并伴随我们一生。呼吸是人体众多功能调节过程中的一项重要功能,对其进行优化可带来诸多健康益处。然而,许多孩子不知道呼吸的机制,即腹式呼吸或膈式呼吸,除此之外,许多孩子通过嘴正常呼吸。本研究旨在验证短期呼吸运动项目对儿童呼吸能力的影响。选取年龄在8 ~ 10岁的儿童21名,分为对照组(CG) 10名,实验组(EG) 11名。通过肺活量测定,对两组患者进行呼吸量(ABC)评估。GE参加了一个持续15到20分钟的呼吸练习(BEP)项目,持续5周。然后,两组再次行ABC。结果显示,eeg的用力肺活量(FVC)值显著增加(p<0.027),表明使用BEP可促进学龄儿童的呼吸能力。进一步的研究应以更大的样本和更长的方案进行。
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引用次数: 0
The Role of Teachers in the Education of Health Professionals in the 21st Century 教师在21世纪卫生专业人员教育中的作用
Pub Date : 1900-01-01 DOI: 10.53902/cicmr.2021.01.000509
Juan Carlos Uribe Cantalejo
Two questions that today's health professors should ask themselves are: Am I teaching my students in the most effective way possible to train professionals with the standards and needs demanded by today's society? Are my students memorizing facts and concepts or are they developing skills that they integrate into their personal and professional lives? In 1910 the Flexner report was published, which gave rise to the first reforms that sought to establish innovations in the education of health professionals, but the great revolution in world education arose from a study published by Barr and Tagg in 1995 where they stressed the importance of changing the paradigm of education centered on content to a new paradigm where education is centered on learning; Thus, in 1998, within the framework of the World Conference on Higher Education, UNESCO expressed the need to update higher education, bringing it closer to the current challenges of society, and in response to this request, in 1999, several European countries signed the Bologna agreement that seeks to improve the quality of higher education by creating the European Higher Education Area.
今天的健康教授应该问自己两个问题:我是否以最有效的方式教我的学生,以培养符合当今社会标准和需求的专业人员?我的学生是在死记硬背事实和概念,还是在培养能融入个人和职业生活的技能?1910年,Flexner报告发表,这引发了第一次改革,试图在卫生专业人员的教育中建立创新,但世界教育的伟大革命源于Barr和Tagg在1995年发表的一项研究,他们强调了将以内容为中心的教育范式转变为以学习为中心的教育新范式的重要性;因此,1998年,在世界高等教育会议的框架内,教科文组织表达了更新高等教育的必要性,使其更接近当前社会的挑战,为了响应这一要求,1999年,几个欧洲国家签署了博洛尼亚协议,旨在通过创建欧洲高等教育区来提高高等教育的质量。
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引用次数: 0
Clinical and Epidemiological Characteristics of COVID-19 in the Barros Luco Hospital Emergency Unit: the First 164 Patients 巴罗斯卢科医院急诊科164例新冠肺炎临床及流行病学特征分析
Pub Date : 1900-01-01 DOI: 10.53902/cicmr.2021.01.000506
Giancarlo Zuccone
Our country was one of many hit by the new coronavirus pandemic, of which its clinical manifestation, mortality rate, laboratory and imaging findings are not still fully understood and in research. This document pretends to elaborate a presentation profile-which includes clinical manifestation, radiologic and laboratory findings-of 164 SARS-CoV2 (+) patients that concurred to the Emergency Service in Barros Luco-Trudeau Hospital. This retrospective-descriptive research paper shows that the most common SARS-CoV2 (+) patient consulting on this ER was predominantly young, not necessarily having a known contact for SARS-CoV2 nor risk factors for complications related to COVID-19. Clinically, dry coughing, cephalalgy and myalgia were more often referred. 74% of patients required house-care only, without any further complications during the disease. Nonetheless, 6% of patients regarding this sample required treatment in the ICU in some point after from onset of the symptoms. In the group of the ICU patients, the most remarkable laboratory differences when compared to the house-care group were show on D-dimer and ferritin blood levels.
我国是受新型冠状病毒大流行影响的国家之一,其临床表现、死亡率、实验室和影像学检查结果仍未完全了解和研究。本文件假装详细介绍了Barros Luco-Trudeau医院急诊服务的164名SARS-CoV2(+)患者的临床表现、放射学和实验室结果。这篇回顾性描述性研究论文表明,在该急诊室就诊的最常见的SARS-CoV2(+)患者主要是年轻人,不一定有已知的SARS-CoV2接触者,也不一定有与COVID-19相关并发症的危险因素。临床上以干咳、头痛、肌痛多见。74%的患者只需要家庭护理,在疾病期间没有任何进一步的并发症。尽管如此,该样本中有6%的患者在症状出现后的某个时间点需要在ICU接受治疗。在ICU患者组中,与居家护理组相比,最显著的实验室差异表现在d -二聚体和铁蛋白血水平上。
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引用次数: 0
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Current Investigations in Clinical and Medical Research
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