Pub Date : 2023-11-01DOI: 10.31557/apjec.2023.6.1.163-168
S. Rahimimoghadam, Safoora Javan, Saeed Yari, Atefeh Kheyrkhah, Mohammad Nourmohamadi
Introduction: Exposure to vibration and noise has been identified to potentially contribute to work-related fatigue, consequently causing a range of adverse effects on job performance.Method: In this study, a sample of 62 city bus drivers underwent examination to evaluate noise levels through the utilization of a TES dosimeter. Additionally, vibration measurements were conducted using an SV 106 vibration meter. Furthermore, the level of occupational fatigue was determined through the utilization of a Swedish fatigue questionnaire. Results: In the conducted study, it was observed that bus drivers were subjected to an average exposure level of 82.18 dB and 0.99 m/s2 for noise and whole-body vibration, respectively, throughout their work shifts. Additionally, their average job fatigue score was measured to be 26.21 out of a total of 200. To comprehensively evaluate the influence of various factors on (WRF), both single-variable and multi-variable analyses were conducted. The result of the univariate tests exhibited a notable association between job fatigue and the Lon life of the vehicle, the type of car seat (spring or inflatable), as well as the level of exposure to vibration and job satisfaction. Moreover, when considering the influencing factors concurrently in the multivariate test, a significant correlation between occupational fatigue and exposure to vibration, as well as the type of chair, was established. Conclusion: Improving the quality of buses by implementing modernized features that minimize vibrations and reduce noise levels can greatly contribute to mitigating fatigue among urban bus drivers.
{"title":"Evaluation of Exposure to Noise and Vibration and Its Effect on Work-related Fatigue","authors":"S. Rahimimoghadam, Safoora Javan, Saeed Yari, Atefeh Kheyrkhah, Mohammad Nourmohamadi","doi":"10.31557/apjec.2023.6.1.163-168","DOIUrl":"https://doi.org/10.31557/apjec.2023.6.1.163-168","url":null,"abstract":"Introduction: Exposure to vibration and noise has been identified to potentially contribute to work-related fatigue, consequently causing a range of adverse effects on job performance.Method: In this study, a sample of 62 city bus drivers underwent examination to evaluate noise levels through the utilization of a TES dosimeter. Additionally, vibration measurements were conducted using an SV 106 vibration meter. Furthermore, the level of occupational fatigue was determined through the utilization of a Swedish fatigue questionnaire. Results: In the conducted study, it was observed that bus drivers were subjected to an average exposure level of 82.18 dB and 0.99 m/s2 for noise and whole-body vibration, respectively, throughout their work shifts. Additionally, their average job fatigue score was measured to be 26.21 out of a total of 200. To comprehensively evaluate the influence of various factors on (WRF), both single-variable and multi-variable analyses were conducted. The result of the univariate tests exhibited a notable association between job fatigue and the Lon life of the vehicle, the type of car seat (spring or inflatable), as well as the level of exposure to vibration and job satisfaction. Moreover, when considering the influencing factors concurrently in the multivariate test, a significant correlation between occupational fatigue and exposure to vibration, as well as the type of chair, was established. Conclusion: Improving the quality of buses by implementing modernized features that minimize vibrations and reduce noise levels can greatly contribute to mitigating fatigue among urban bus drivers.","PeriodicalId":270461,"journal":{"name":"Asian Pacific Journal of Environment and Cancer","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139294090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.31557/apjec.2023.6.1.161-165
Tina Khavari, Fatemeh Azizi, Fatameh Asadipour, Mojtaba Azari, Mohammad Reza Taherian, Mobina Karimiyan, Yaser Soleimani, Aram Halimi, Alireza Mosavi Jarrahi
Background: This protocol recommends ways to conduct a systematic review and meta-analysis on the association between isophorone exposure and cancer risk. Methods: This study will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligible studies will include observational research examining the association between isophorone exposure and cancer outcomes. General search terms will be used to search databases such as PubMed, Web of Science, and Scopus. Two independent reviewers will screen articles, extract data, and assess study quality and risk of bias. Data synthesis and analysis will include meta-analysis, subgroup analyses, sensitivity analyses, and assessment of publication bias. Results: The systematic review and meta-analysis will provide a comprehensive assessment of the association between isophorone exposure and cancer risk. Data from multiple studies will be pooled to achieve an overall estimate of the association, considering sources of heterogeneity and evaluating the quality of included studies. Publication bias will also be assessed. The findings will contribute to our understanding of the potential health effects of isophorone exposure and inform future research and decision-making. Conclusion: This protocol outlines a systematic and transparent approach to assessing the association between isophorone exposure and the risk of cancer. This study will provide insights into the potential health implications of isophorone exposure, preventive measures, and regulatory decisions. By following established guidelines and employing methodology, this study will provide an evidence-based assessment of the available literature, advancing our understanding of the association between isophorone exposure and cancer risk.
背景：本方案建议就异佛尔酮暴露与癌症风险之间的关系进行系统回顾和荟萃分析。研究方法本研究将遵循系统综述和荟萃分析首选报告项目（PRISMA）指南。符合条件的研究将包括考察异佛尔酮暴露与癌症结果之间关系的观察性研究。一般检索词将用于检索 PubMed、Web of Science 和 Scopus 等数据库。两名独立审稿人将筛选文章、提取数据并评估研究质量和偏倚风险。数据综合与分析将包括荟萃分析、亚组分析、敏感性分析和出版偏倚评估。结果：系统综述和荟萃分析将全面评估异佛尔酮暴露与癌症风险之间的关系。考虑到异质性的来源并评估纳入研究的质量，将对多项研究的数据进行汇总，以得出相关性的总体估计值。还将对发表偏倚进行评估。研究结果将有助于我们了解接触异佛尔酮对健康的潜在影响，并为今后的研究和决策提供参考。结论该方案概述了评估异佛尔酮暴露与癌症风险之间关系的系统而透明的方法。这项研究将有助于深入了解接触异佛尔酮对健康的潜在影响、预防措施和监管决策。通过遵循既定准则和采用方法，本研究将对现有文献进行循证评估，从而加深我们对接触异佛尔酮与癌症风险之间关系的理解。
{"title":"The Study of Exposure to Isophorone and the Risk of Getting Cancer: A Systematic Review and Meta-analysis Protocol","authors":"Tina Khavari, Fatemeh Azizi, Fatameh Asadipour, Mojtaba Azari, Mohammad Reza Taherian, Mobina Karimiyan, Yaser Soleimani, Aram Halimi, Alireza Mosavi Jarrahi","doi":"10.31557/apjec.2023.6.1.161-165","DOIUrl":"https://doi.org/10.31557/apjec.2023.6.1.161-165","url":null,"abstract":"Background: This protocol recommends ways to conduct a systematic review and meta-analysis on the association between isophorone exposure and cancer risk. Methods: This study will follow the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligible studies will include observational research examining the association between isophorone exposure and cancer outcomes. General search terms will be used to search databases such as PubMed, Web of Science, and Scopus. Two independent reviewers will screen articles, extract data, and assess study quality and risk of bias. Data synthesis and analysis will include meta-analysis, subgroup analyses, sensitivity analyses, and assessment of publication bias. Results: The systematic review and meta-analysis will provide a comprehensive assessment of the association between isophorone exposure and cancer risk. Data from multiple studies will be pooled to achieve an overall estimate of the association, considering sources of heterogeneity and evaluating the quality of included studies. Publication bias will also be assessed. The findings will contribute to our understanding of the potential health effects of isophorone exposure and inform future research and decision-making. Conclusion: This protocol outlines a systematic and transparent approach to assessing the association between isophorone exposure and the risk of cancer. This study will provide insights into the potential health implications of isophorone exposure, preventive measures, and regulatory decisions. By following established guidelines and employing methodology, this study will provide an evidence-based assessment of the available literature, advancing our understanding of the association between isophorone exposure and cancer risk.","PeriodicalId":270461,"journal":{"name":"Asian Pacific Journal of Environment and Cancer","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139297659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-11-01DOI: 10.31557/apjec.2023.6.1.87-91
Salman Sheikhi, Negar Asghari Hosori, Saeed Yari
Cancer is one of the most common causes of death. One of the most important problems in cancer treatment is the side effects of drugs and treatments. The limiting factor in cancer treatment is the lack of selectivity of drugs against cancer cells. Today, nanotechnology has been able to help in the diagnosis and treatment of this disease because most biological processes such as the creation of cancer occur in nano dimensions, therefore, in order to reduce side effects and improve existing drugs, various drug delivery systems based on nanotechnology have been developed. Cancer researchers use the ability of nanotechnology to evaluate cells and achieve the following goals: 1- Simulating the reaction of cells with protein and nucleic acids at the molecular level, and then obtaining a proper knowledge of cell behavior. 2- Studying the structure and function of intracellular proteins and research in the field of proteomics. 3- Initial determination of cancer. This article is written based on reviews of various articles in reputable journals and books related to the use of nanotechnology in cancer treatment. The selection of sources is based on suitability to the topic, year of research, non-repetition and comprehensiveness of the content. The effective treatment of cancer with the least side effects is considered one of the challenges of medical and pharmaceutical sciences, and the introduction of nanotechnology into therapeutic fields promises the production of a new group of anti-cancer drugs that provide diagnostic and therapeutic capabilities simultaneously. These structures have a special place in cancer treatment as drug carriers and optically and thermally active substance
{"title":"An Overview of the Application of Nanoscience in Cancer Diagnosis and Treatment","authors":"Salman Sheikhi, Negar Asghari Hosori, Saeed Yari","doi":"10.31557/apjec.2023.6.1.87-91","DOIUrl":"https://doi.org/10.31557/apjec.2023.6.1.87-91","url":null,"abstract":"Cancer is one of the most common causes of death. One of the most important problems in cancer treatment is the side effects of drugs and treatments. The limiting factor in cancer treatment is the lack of selectivity of drugs against cancer cells. Today, nanotechnology has been able to help in the diagnosis and treatment of this disease because most biological processes such as the creation of cancer occur in nano dimensions, therefore, in order to reduce side effects and improve existing drugs, various drug delivery systems based on nanotechnology have been developed. Cancer researchers use the ability of nanotechnology to evaluate cells and achieve the following goals: 1- Simulating the reaction of cells with protein and nucleic acids at the molecular level, and then obtaining a proper knowledge of cell behavior. 2- Studying the structure and function of intracellular proteins and research in the field of proteomics. 3- Initial determination of cancer. This article is written based on reviews of various articles in reputable journals and books related to the use of nanotechnology in cancer treatment. The selection of sources is based on suitability to the topic, year of research, non-repetition and comprehensiveness of the content. The effective treatment of cancer with the least side effects is considered one of the challenges of medical and pharmaceutical sciences, and the introduction of nanotechnology into therapeutic fields promises the production of a new group of anti-cancer drugs that provide diagnostic and therapeutic capabilities simultaneously. These structures have a special place in cancer treatment as drug carriers and optically and thermally active substance","PeriodicalId":270461,"journal":{"name":"Asian Pacific Journal of Environment and Cancer","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139301046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Cancer is a significant health burden. This research describes the current state of cancer epidemiology and trends in a tertiary cancer center in Thailand. Materials and Methods: Data from Saraburi Hospital electronic medical records (SBH), Thai cancer based (TCB), Pathological data, and Saraburi Provincial Public Health Office (PPHO) were merged using identification numbers and birthdates, establishing Saraburi hospital-based cancer registry. Cancers were categorized according to ICD10. Population at risk was obtained from the Thai national census department. Prevalence was calculated by dividing cancer cases by population in each district. Cause-specific incidence rates (CIRs) and mortality rates (CMRs) were estimated for cancer types and gender. Age-standardized incidence rates (ASIRs) and mortality rates (ASMRs) were calculated, weighting with 2020 Thai population data. Results: Between 2018 and 2022, 10,669 cases were identified in Saraburi province. Breast cancer was the most diagnosed cancer (17.6%), followed by colorectal (13.4%), lung cancer (7.8%), cervical cancer (5.9%), and liver cancer (5.5%). ASIR peaked at 509 (492-527) per 100,000 person-years in 2018 and decreased to 232 (220-244) per 100,000 person-years in 2022. Leading cancers for males were colorectal, lung, liver; females had breast, colorectal, cervical and lung cancer. 5-year prevalence was 1.7%. Males died mostly from lung and liver cancer (ASMR 30 and 29 per 100,000 person-years), while females died from breast cancer (ASMR 21 per 100,000 person-years). Life-time cumulative risk of death from cancer was 11%. Conclusion: This study reveals the cancer burden in Saraburi province, emphasizing the need for preventive strategies and resource allocations. The establishment of a cancer registry warrants future research.
{"title":"Unveiling Cancer Burden: An Epidemiological Study in a Tertiary Cancer Center, Thailand","authors":"Voralak Vichapat, Arunrat Hinon, Jittichai Boonaob, Pintumas Ukritanon, Banyong Meeniran, Somsiri Pansaksiri","doi":"10.31557/apjec.2023.6.1.39-48","DOIUrl":"https://doi.org/10.31557/apjec.2023.6.1.39-48","url":null,"abstract":"Objective: Cancer is a significant health burden. This research describes the current state of cancer epidemiology and trends in a tertiary cancer center in Thailand. Materials and Methods: Data from Saraburi Hospital electronic medical records (SBH), Thai cancer based (TCB), Pathological data, and Saraburi Provincial Public Health Office (PPHO) were merged using identification numbers and birthdates, establishing Saraburi hospital-based cancer registry. Cancers were categorized according to ICD10. Population at risk was obtained from the Thai national census department. Prevalence was calculated by dividing cancer cases by population in each district. Cause-specific incidence rates (CIRs) and mortality rates (CMRs) were estimated for cancer types and gender. Age-standardized incidence rates (ASIRs) and mortality rates (ASMRs) were calculated, weighting with 2020 Thai population data. Results: Between 2018 and 2022, 10,669 cases were identified in Saraburi province. Breast cancer was the most diagnosed cancer (17.6%), followed by colorectal (13.4%), lung cancer (7.8%), cervical cancer (5.9%), and liver cancer (5.5%). ASIR peaked at 509 (492-527) per 100,000 person-years in 2018 and decreased to 232 (220-244) per 100,000 person-years in 2022. Leading cancers for males were colorectal, lung, liver; females had breast, colorectal, cervical and lung cancer. 5-year prevalence was 1.7%. Males died mostly from lung and liver cancer (ASMR 30 and 29 per 100,000 person-years), while females died from breast cancer (ASMR 21 per 100,000 person-years). Life-time cumulative risk of death from cancer was 11%. Conclusion: This study reveals the cancer burden in Saraburi province, emphasizing the need for preventive strategies and resource allocations. The establishment of a cancer registry warrants future research.","PeriodicalId":270461,"journal":{"name":"Asian Pacific Journal of Environment and Cancer","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139296948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-19DOI: 10.31557/apjec.2022.5.1.17-23
Alex Barimah Owusu, M. Asare, R. Owusu
Objective: This study used the Geographic Intelligent Systems to examine the location of cervical cancer screening (CCS) facilities and their proximity to the residential location of Women Living with HIV (WLWH) and how they could influence WLWH CCS behaviors. Methods: We used deidentified existing data from Komfo Anokye Teaching Hospital (KATH) on WLWH and geocoded them to their community of residence as points using Google Earth Pro version 7.3.0. Transport fares from KATH to communities identified in the screening database were also obtained. The location of KATH was digitized from google earth and validated from the GIS database from the Remote Sensing and GIS application Laboratory, University of Ghana. We calculated distances and other proximity information between each point from the KATH. We used the spatial-analytical tool of kernel density for the density analysis and fitted a smoothly tapered surface using Esri’s ArcGIS Desktop 10.8. We performed Shapiro-Wilk normal distribution test to assess the significance of the clustering. Results: Data on 708 WLWH’s residential locations and transportation fares were analyzed. We find a significant clustering near KATH. Close to 50% cluster within 5km from KATH whiles 85.8% of the respondents live within 10.2 km from KATH. Shapiro-Wilk normality test shows W=0.30221, p-value < 0.05. The minimum cost per commercial transportation is approximately GHC 2.00 (US dollar ~ $0.26 whiles those living beyond 3-5 km will pay approximately GHC 3.00 (~$0.39). The highest cost payable by the farthest distance using a commercial bus is GHC 50.00. (~$ 6.00). The majority of respondents will pay about GHC 10.00 (~$1.50) for transportation (i.e., round trip) to access SCC facilities. Conclusions: In an economy where a family lives on less than $2.00 per day, any additional cost resulting from transportation will likely create CCS hesitancy and that self-sampling may be a recommended solution.
{"title":"Using GIS to Understand Cervical Cancer Screening Behaviors among Women Living with HIV (WLWH) in Ghana","authors":"Alex Barimah Owusu, M. Asare, R. Owusu","doi":"10.31557/apjec.2022.5.1.17-23","DOIUrl":"https://doi.org/10.31557/apjec.2022.5.1.17-23","url":null,"abstract":"Objective: This study used the Geographic Intelligent Systems to examine the location of cervical cancer screening (CCS) facilities and their proximity to the residential location of Women Living with HIV (WLWH) and how they could influence WLWH CCS behaviors. Methods: We used deidentified existing data from Komfo Anokye Teaching Hospital (KATH) on WLWH and geocoded them to their community of residence as points using Google Earth Pro version 7.3.0. Transport fares from KATH to communities identified in the screening database were also obtained. The location of KATH was digitized from google earth and validated from the GIS database from the Remote Sensing and GIS application Laboratory, University of Ghana. We calculated distances and other proximity information between each point from the KATH. We used the spatial-analytical tool of kernel density for the density analysis and fitted a smoothly tapered surface using Esri’s ArcGIS Desktop 10.8. We performed Shapiro-Wilk normal distribution test to assess the significance of the clustering. Results: Data on 708 WLWH’s residential locations and transportation fares were analyzed. We find a significant clustering near KATH. Close to 50% cluster within 5km from KATH whiles 85.8% of the respondents live within 10.2 km from KATH. Shapiro-Wilk normality test shows W=0.30221, p-value < 0.05. The minimum cost per commercial transportation is approximately GHC 2.00 (US dollar ~ $0.26 whiles those living beyond 3-5 km will pay approximately GHC 3.00 (~$0.39). The highest cost payable by the farthest distance using a commercial bus is GHC 50.00. (~$ 6.00). The majority of respondents will pay about GHC 10.00 (~$1.50) for transportation (i.e., round trip) to access SCC facilities. Conclusions: In an economy where a family lives on less than $2.00 per day, any additional cost resulting from transportation will likely create CCS hesitancy and that self-sampling may be a recommended solution.","PeriodicalId":270461,"journal":{"name":"Asian Pacific Journal of Environment and Cancer","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124748636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-28DOI: 10.31557/apjec.2022.5.1.11-16
Elizabeth Feloni Lukito, K. Tandarto, M. M. Stella, I. Ivan, Harvey Sudharta, Gilbert Golahi, Kenny Wijaya Sutanto, Y. Turana, B. T. Santi, Yanto Budiman, Yopi Simargi
Background: Existing air quality is decreasing, as evidenced by the increase in air pollution. Air pollution does not only affect the respiratory system, but also affecting the nervous system, and furthermore causing impaired cognitive function that can be predicted through the image of the hippocampus. Objective: This study wanted to determine the significance of the relationship between PM2.5 (Particulate Matter) pollutant exposure and hippocampal volume in adults. Method: This research is a PRISMA 2020 based systematic study using Google Scholar, PubMed, and Proquest as databases. Research inclusion criteria were studies with subjects over 19 years old, using MRI techniques, published in English, having sufficient data for extraction. Result: There are 5 studies from 2015 to 2020 which stated that there was no statistically significant relationship between PM2.5 pollutant exposure and hippocampal volume (n = 5) (P-value > 0.05, 0.71, 0.8, 0.32), and the study obtained significant results (n = 1) (P-value < 0.005). Discussion: Although the results of the study did not prove a significant difference in hippocampal volume, several recent theories regarding hippocampal neurogenesis in adults are able to support these results. Conclusion: From this study, it was not proven that there was a significant relationship between PM2.5 pollutant exposure and hippocampal volume.
{"title":"The Association between PM2.5 Exposure and Hippocampal Volume: A Systematic Review","authors":"Elizabeth Feloni Lukito, K. Tandarto, M. M. Stella, I. Ivan, Harvey Sudharta, Gilbert Golahi, Kenny Wijaya Sutanto, Y. Turana, B. T. Santi, Yanto Budiman, Yopi Simargi","doi":"10.31557/apjec.2022.5.1.11-16","DOIUrl":"https://doi.org/10.31557/apjec.2022.5.1.11-16","url":null,"abstract":"Background: Existing air quality is decreasing, as evidenced by the increase in air pollution. Air pollution does not only affect the respiratory system, but also affecting the nervous system, and furthermore causing impaired cognitive function that can be predicted through the image of the hippocampus. Objective: This study wanted to determine the significance of the relationship between PM2.5 (Particulate Matter) pollutant exposure and hippocampal volume in adults. Method: This research is a PRISMA 2020 based systematic study using Google Scholar, PubMed, and Proquest as databases. Research inclusion criteria were studies with subjects over 19 years old, using MRI techniques, published in English, having sufficient data for extraction. Result: There are 5 studies from 2015 to 2020 which stated that there was no statistically significant relationship between PM2.5 pollutant exposure and hippocampal volume (n = 5) (P-value > 0.05, 0.71, 0.8, 0.32), and the study obtained significant results (n = 1) (P-value < 0.005). Discussion: Although the results of the study did not prove a significant difference in hippocampal volume, several recent theories regarding hippocampal neurogenesis in adults are able to support these results. Conclusion: From this study, it was not proven that there was a significant relationship between PM2.5 pollutant exposure and hippocampal volume.","PeriodicalId":270461,"journal":{"name":"Asian Pacific Journal of Environment and Cancer","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122835877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-28DOI: 10.31557/apjec.2022.5.1.3-10
Sankalp Singh, S. Bhatnagar, Nishant Lohia, Anand Subramananiam, D. Raman, H. Murthy, Manoj Prashar, S. Viswanath, G. Trivedi
Purpose: Gall bladder cancer (GBC) is one of the commonest and deadliest cancers of Northern and Eastern India. The absence of a population-based cancer registry in Uttar Pradesh and Bihar has resulted in a lack of statistical information even though data from several hospital-based registries suggests that incidence rates of GBC may be one of the highest in the world. We present the four-year data on GBC from our tertiary-level multispeciality hospital. Materials & Methods: This is a retrospective and analytical study. All patients of histopathologically proven GBC over four years were included and geographic, demographic and clinical data was collected and presented. Follow up, where available, was used to assess survival at 12 months and factors affecting it. Results: A total of 245 patients with GBC were diagnosed during the study period of which more than two-thirds were women. The majority of cases at our hospital were from the state of Uttar Pradesh with the highest number coming from the Eastern districts closer to the river Ganga and its tributaries. 26.5% of cases were early stage and surgically resectable, 19.6% were locally advanced and unresectable while 53.9% were metastatic at presentation. Age, stage and radical surgery as treatment had a significant association with survival at 12 months. Conclusion: GBC has an extremely high incidence in the Northern plains of India. There is a high suspicion of its association with increasing pollution of the major rivers of the region. Early detection is crucial as definitive surgery is the only curative option with any significant improvement of survival.
{"title":"Epidemiological and Geographical Profile of Gall Bladder Cancer Patients from a Hospital-based Registry of Northern Gangetic Plains","authors":"Sankalp Singh, S. Bhatnagar, Nishant Lohia, Anand Subramananiam, D. Raman, H. Murthy, Manoj Prashar, S. Viswanath, G. Trivedi","doi":"10.31557/apjec.2022.5.1.3-10","DOIUrl":"https://doi.org/10.31557/apjec.2022.5.1.3-10","url":null,"abstract":"Purpose: Gall bladder cancer (GBC) is one of the commonest and deadliest cancers of Northern and Eastern India. The absence of a population-based cancer registry in Uttar Pradesh and Bihar has resulted in a lack of statistical information even though data from several hospital-based registries suggests that incidence rates of GBC may be one of the highest in the world. We present the four-year data on GBC from our tertiary-level multispeciality hospital. Materials & Methods: This is a retrospective and analytical study. All patients of histopathologically proven GBC over four years were included and geographic, demographic and clinical data was collected and presented. Follow up, where available, was used to assess survival at 12 months and factors affecting it. Results: A total of 245 patients with GBC were diagnosed during the study period of which more than two-thirds were women. The majority of cases at our hospital were from the state of Uttar Pradesh with the highest number coming from the Eastern districts closer to the river Ganga and its tributaries. 26.5% of cases were early stage and surgically resectable, 19.6% were locally advanced and unresectable while 53.9% were metastatic at presentation. Age, stage and radical surgery as treatment had a significant association with survival at 12 months. Conclusion: GBC has an extremely high incidence in the Northern plains of India. There is a high suspicion of its association with increasing pollution of the major rivers of the region. Early detection is crucial as definitive surgery is the only curative option with any significant improvement of survival.","PeriodicalId":270461,"journal":{"name":"Asian Pacific Journal of Environment and Cancer","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122054094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-24DOI: 10.31557/apjec.2021.4.1.33-38
N. Anggorowati, I. ., Amira L. Dhyanti, Hafidh Arkananda, Salsabilla Hasna Mutiara Rizki, S. A. Setiawan, M. R. Bagaskoro, M. Hardianti
Introduction: Lymphoma as a heterogeneous disease has various characteristics not only in the clinical manifestation but also in sociodemographic aspect. Epidemiological data with sociodemographic description in lymphoma is still unexplored. Objective: This study aimed to provide updated and detailed description of lymphoma with emphasis on patient characteristics, sociodemographic data and hematologic findings. Materials and Methods: This was an observational descriptive study with a cross-sectional design. The data were from the medical records in Dr. Sardjito Hospital, a national referral hospital in the Special Region of Yogyakarta Province Indonesia from 2012 to 2018. All lymphoma patients > 18 years were included. Patients’ characteristics, socio-demographic indicators, tumor characteristic and hematological finding were recorded. The difference of socio-demographic, clinical and laboratory characteristics between Non Hodgkin Lymphoma (NHL) and Hodgkin Lymphoma (HL) was analyzed with Chi-Square, Fisher-Exact, and Mann-Whitney test (P <0.05 was statistically significant). Results: There were 675 cases. Male predominated, mean age at diagnosis was 54.1 for NHL and 42.3 for HL. There was significant difference in the mean of age (p=0.000), occupation (P=0.035) and educational level (P=0.020) between NHL and HL patients. B cell NHL was found to be the most common type of lymphoma, with DLBCL being the most common histopathological type. Hematological findings were found to be within the normal range. Conclusion: There are significant difference in the mean of age, occupation and education level between NHL and HL patients. Further study to explain the scientific reasons of the difference are required.
{"title":"Sociodemographic and Clinicopathological Features of Lymphoma Patients in Indonesia: A report from Special Region of Yogyakarta Province","authors":"N. Anggorowati, I. ., Amira L. Dhyanti, Hafidh Arkananda, Salsabilla Hasna Mutiara Rizki, S. A. Setiawan, M. R. Bagaskoro, M. Hardianti","doi":"10.31557/apjec.2021.4.1.33-38","DOIUrl":"https://doi.org/10.31557/apjec.2021.4.1.33-38","url":null,"abstract":"Introduction: Lymphoma as a heterogeneous disease has various characteristics not only in the clinical manifestation but also in sociodemographic aspect. Epidemiological data with sociodemographic description in lymphoma is still unexplored. Objective: This study aimed to provide updated and detailed description of lymphoma with emphasis on patient characteristics, sociodemographic data and hematologic findings. Materials and Methods: This was an observational descriptive study with a cross-sectional design. The data were from the medical records in Dr. Sardjito Hospital, a national referral hospital in the Special Region of Yogyakarta Province Indonesia from 2012 to 2018. All lymphoma patients > 18 years were included. Patients’ characteristics, socio-demographic indicators, tumor characteristic and hematological finding were recorded. The difference of socio-demographic, clinical and laboratory characteristics between Non Hodgkin Lymphoma (NHL) and Hodgkin Lymphoma (HL) was analyzed with Chi-Square, Fisher-Exact, and Mann-Whitney test (P <0.05 was statistically significant). Results: There were 675 cases. Male predominated, mean age at diagnosis was 54.1 for NHL and 42.3 for HL. There was significant difference in the mean of age (p=0.000), occupation (P=0.035) and educational level (P=0.020) between NHL and HL patients. B cell NHL was found to be the most common type of lymphoma, with DLBCL being the most common histopathological type. Hematological findings were found to be within the normal range. Conclusion: There are significant difference in the mean of age, occupation and education level between NHL and HL patients. Further study to explain the scientific reasons of the difference are required.","PeriodicalId":270461,"journal":{"name":"Asian Pacific Journal of Environment and Cancer","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116031883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-24DOI: 10.31557/apjec.2021.4.1.25-31
C. Aryanti, I. Sudarsa, Putu Anda Tusta Adiputra
Introduction: Micropapillary thyroid carcinoma was emerging as an epidemic disease worldwide. Due to its unaggressiveness and slow-growing feature, either doing active surveillance or surgical approach were controversial for its management. This meta analysis aimed to determine the pooled proportion outcomes of doing active surveillance and surgery in micropapillary thyroid carcinoma. Methods: This meta analysis of the results in doing active surveillance and surgical approach for micropapillary thyroid carcinoma, designed followed the PRISMA guidelines. Relevant studies were obtained from Medline (2008-2018) and SCOPUS (2008-2018) in the last 20 years. The scope of data collection is about the author, year of study, and number of subjects. The parameter of this study was pooled proportion. Data were analyzed by MedCalc 13.5 and the significance limit was 0.05. Results: The pooled proportion of cases of surgery conversion, increasing tumor size more than 3 cm, and the presence of lymph node metastases during active surveillance of micropapillary thyroid carcinoma were 14.996; 6.125%; and 4.988%, respectively. The pooled proportion of cases of recurrence and lymph node metastases after surgery of micropapillary thyroid carcinoma were 3.539% and 14.071%, respectively. Discussion: In this study, it was showed that result was favorable in doing active surveillance. The rate of lymph node metastases were comparable in non and interventional group. However, this approach should be considered cases by cases. Many individual factors like age, gender, and comorbidities should be considered. Conclusion: Active surveillance was a safe and considered approach for micropapillary thyroid carcinoma. However, some risk factor should be considered for surveillance exclusion.
{"title":"Meta Analysis of the Outcomes in Doing Active Surveillance and Surgical Approach for Micropapillary Thyroid Carcinoma","authors":"C. Aryanti, I. Sudarsa, Putu Anda Tusta Adiputra","doi":"10.31557/apjec.2021.4.1.25-31","DOIUrl":"https://doi.org/10.31557/apjec.2021.4.1.25-31","url":null,"abstract":"Introduction: Micropapillary thyroid carcinoma was emerging as an epidemic disease worldwide. Due to its unaggressiveness and slow-growing feature, either doing active surveillance or surgical approach were controversial for its management. This meta analysis aimed to determine the pooled proportion outcomes of doing active surveillance and surgery in micropapillary thyroid carcinoma. Methods: This meta analysis of the results in doing active surveillance and surgical approach for micropapillary thyroid carcinoma, designed followed the PRISMA guidelines. Relevant studies were obtained from Medline (2008-2018) and SCOPUS (2008-2018) in the last 20 years. The scope of data collection is about the author, year of study, and number of subjects. The parameter of this study was pooled proportion. Data were analyzed by MedCalc 13.5 and the significance limit was 0.05. Results: The pooled proportion of cases of surgery conversion, increasing tumor size more than 3 cm, and the presence of lymph node metastases during active surveillance of micropapillary thyroid carcinoma were 14.996; 6.125%; and 4.988%, respectively. The pooled proportion of cases of recurrence and lymph node metastases after surgery of micropapillary thyroid carcinoma were 3.539% and 14.071%, respectively. Discussion: In this study, it was showed that result was favorable in doing active surveillance. The rate of lymph node metastases were comparable in non and interventional group. However, this approach should be considered cases by cases. Many individual factors like age, gender, and comorbidities should be considered. Conclusion: Active surveillance was a safe and considered approach for micropapillary thyroid carcinoma. However, some risk factor should be considered for surveillance exclusion.","PeriodicalId":270461,"journal":{"name":"Asian Pacific Journal of Environment and Cancer","volume":"44 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114031000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-01-24DOI: 10.31557/apjec.2021.4.1.19-24
M. Zaker, Amin Safaripour, Sima Rahdaneh zade sabegh, S. Barjasteh
Background: Cancer and its treatment can have a profound effect on the appearance of the patient, the aim of this systematic review was to identify challenges among patients with breast cancer and the effective intervention for coping it. Materials and Methods: This systematic review that was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines between January 2000 to December 2018. The keywords searched included: “breast cancer,” “breast neoplasm,” “breast tumor,” “educational intervention,” “cognitive program,” “body image,” “supportive intervention,” “family,” “behavioral therapy,” “counselling,” “husband,” and “spouse,”. The Google Scholar, ISI Web of Science, Science Direct, PubMed and Scopus databases were searched. Results: After screening and review of article eligibility, ten were included in the study. The selected articles were compared regarding the aims of interest. The results showed some effective factor in the improvement of patients with breast cancer including family support, supportive programs, physically and psychologically support with family and relatives, holistic care, psychological screening and consultation, social support, family involvement in the treatment process of women with breast cancer. Conclusion: According to the results, the most problem of all articles was body image and the best effective way is family support.
背景:癌症及其治疗可以对患者的外表产生深远的影响，本系统综述的目的是确定乳腺癌患者面临的挑战和有效的干预措施。材料和方法:本系统评价是在2000年1月至2018年12月期间根据系统评价和荟萃分析(PRISMA)指南的首选报告项目进行的。搜索的关键词包括:“乳腺癌”、“乳腺肿瘤”、“教育干预”、“认知项目”、“身体形象”、“支持性干预”、“家庭”、“行为治疗”、“咨询”、“丈夫”和“配偶”。检索了Google Scholar、ISI Web of Science、Science Direct、PubMed和Scopus数据库。结果:经过筛选和文章合格性审查，10例纳入研究。对所选文章的兴趣目的进行了比较。结果表明，家庭支持、支持性方案、家庭和亲属的身心支持、整体护理、心理筛查和咨询、社会支持、家庭参与乳腺癌患者治疗过程是改善乳腺癌患者的有效因素。结论:所有文章中存在的问题最多的是身体形象，最有效的方法是家庭支持。
{"title":"Supportive Intervention Challenges for Patients with Breast Cancer: A Systematic Review","authors":"M. Zaker, Amin Safaripour, Sima Rahdaneh zade sabegh, S. Barjasteh","doi":"10.31557/apjec.2021.4.1.19-24","DOIUrl":"https://doi.org/10.31557/apjec.2021.4.1.19-24","url":null,"abstract":"Background: Cancer and its treatment can have a profound effect on the appearance of the patient, the aim of this systematic review was to identify challenges among patients with breast cancer and the effective intervention for coping it. Materials and Methods: This systematic review that was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines between January 2000 to December 2018. The keywords searched included: “breast cancer,” “breast neoplasm,” “breast tumor,” “educational intervention,” “cognitive program,” “body image,” “supportive intervention,” “family,” “behavioral therapy,” “counselling,” “husband,” and “spouse,”. The Google Scholar, ISI Web of Science, Science Direct, PubMed and Scopus databases were searched. Results: After screening and review of article eligibility, ten were included in the study. The selected articles were compared regarding the aims of interest. The results showed some effective factor in the improvement of patients with breast cancer including family support, supportive programs, physically and psychologically support with family and relatives, holistic care, psychological screening and consultation, social support, family involvement in the treatment process of women with breast cancer. Conclusion: According to the results, the most problem of all articles was body image and the best effective way is family support. ","PeriodicalId":270461,"journal":{"name":"Asian Pacific Journal of Environment and Cancer","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130753344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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