M. O. Karaytuğ, Lut Tamam, M. Demirkol, Zeynep Namli
{"title":"Bipolar Bozukluk Tanılı Hastalarda Tedaviye Uyum ve İlişkili Faktörler","authors":"M. O. Karaytuğ, Lut Tamam, M. Demirkol, Zeynep Namli","doi":"10.17827/aktd.1055451","DOIUrl":"https://doi.org/10.17827/aktd.1055451","url":null,"abstract":"","PeriodicalId":272457,"journal":{"name":"Arşiv Kaynak Tarama Dergisi","volume":"387 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120891207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoplazmik Retikulumda Katlanmamış Protein Cevabı ile İlişkili Hastalıklar","authors":"Figen ABATAY SEL, F. Oğuz","doi":"10.17827/aktd.984446","DOIUrl":"https://doi.org/10.17827/aktd.984446","url":null,"abstract":"","PeriodicalId":272457,"journal":{"name":"Arşiv Kaynak Tarama Dergisi","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116406715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"İnvaziv Olmayan Prenatal Teste Etik Bakış","authors":"Kadriye Esen, Emine GERÇEK ÖTER, Hale UYAR HAZAR","doi":"10.17827/aktd.1013719","DOIUrl":"https://doi.org/10.17827/aktd.1013719","url":null,"abstract":"","PeriodicalId":272457,"journal":{"name":"Arşiv Kaynak Tarama Dergisi","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132683967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cancers generally contain multiple genetic and epigenetic abnormalities, but several key genes maintain the malignant phenotype and cellular survival. The PI3K/Akt/mTOR pathway is a central signaling system that plays a role in many important physiological events. Since the PI3K/Akt/mTOR pathway is used by many tumor types, it is thought that inhibitors used against this pathway may have a wide therapeutic efficacy. Significant response rates could not be obtained in phase 1 studies with any of the agents in monotherapy, and other options are being investigated by administering high doses in short periods and combining drugs that may affect different pathways.
{"title":"Kanserde Hedefe Yönelik Tedavi: PI3K/Akt/mTOR İnhibitörleri","authors":"Serhan Küpeli","doi":"10.17827/aktd.1001226","DOIUrl":"https://doi.org/10.17827/aktd.1001226","url":null,"abstract":"Cancers generally contain multiple genetic and epigenetic abnormalities, but several key genes maintain the malignant phenotype and cellular survival. The PI3K/Akt/mTOR pathway is a central signaling system that plays a role in many important physiological events. Since the PI3K/Akt/mTOR pathway is used by many tumor types, it is thought that inhibitors used against this pathway may have a wide therapeutic efficacy. Significant response rates could not be obtained in phase 1 studies with any of the agents in monotherapy, and other options are being investigated by administering high doses in short periods and combining drugs that may affect different pathways.","PeriodicalId":272457,"journal":{"name":"Arşiv Kaynak Tarama Dergisi","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124106252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"NLRP3 İnflamazom Aktivasyon ve Düzenleme Mekanizmalarına Genel Bir Bakış","authors":"Dilek Şaker, S. Polat","doi":"10.17827/aktd.1008686","DOIUrl":"https://doi.org/10.17827/aktd.1008686","url":null,"abstract":"","PeriodicalId":272457,"journal":{"name":"Arşiv Kaynak Tarama Dergisi","volume":"148 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115543103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Although organ regeneration is common in the animal kingdom, it can also occur in humans after liver injury. To date, in the clinical trials for cardiac regeneration have been focused on cell-based therapies. However, since the effects of these treatments on cardiac function are negligible, studies on the mechanisms that regulate cardiac regeneration in mammals have accelerated. Emerging research on endogenous heart regeneration of Zebrafish (Danio rerio) is providing new insight into congenital mechanisms for complex organ regeneration. Current studies demonstrate that, mammalian neonatal hearts also have a regeneration capacity similar to Zebrafish, but this regenerative capacity is limited to the first few days after birth. Although many molecular and cellular mechanisms have been identified in this process, the Hippo signaling pathway has received the greatest attention. The activity of this pathway depends on the nuclear/cytoplasmic localization of YAP and is controlled by a number of molecular factors such as ROS, ECM and miRNAs. In the last few years studies that examining the effects of the Hippo pathway on the cardiomyocyte cell cycle have shown that components of this pathway are promising for cardiac regeneration in adults. In this review, it is aimed to give information about the Hippo pathway, which we think has an important role in reversing the damage in adult mammalian heart tissue and in the development of new therapeutic targets, and its components.
{"title":"Neonatal Kalp Rejenerasyonu: Hippo Sinyal Yolağı’nın Rolü","authors":"Yasemin Özküçük, Abdullah Tuli","doi":"10.17827/aktd.1030555","DOIUrl":"https://doi.org/10.17827/aktd.1030555","url":null,"abstract":"Although organ regeneration is common in the animal kingdom, it can also occur in humans after liver injury. To date, in the clinical trials for cardiac regeneration have been focused on cell-based therapies. However, since the effects of these treatments on cardiac function are negligible, studies on the mechanisms that regulate cardiac regeneration in mammals have accelerated. Emerging research on endogenous heart regeneration of Zebrafish (Danio rerio) is providing new insight into congenital mechanisms for complex organ regeneration. Current studies demonstrate that, mammalian neonatal hearts also have a regeneration capacity similar to Zebrafish, but this regenerative capacity is limited to the first few days after birth. Although many molecular and cellular mechanisms have been identified in this process, the Hippo signaling pathway has received the greatest attention. The activity of this pathway depends on the nuclear/cytoplasmic localization of YAP and is controlled by a number of molecular factors such as ROS, ECM and miRNAs. In the last few years studies that examining the effects of the Hippo pathway on the cardiomyocyte cell cycle have shown that components of this pathway are promising for cardiac regeneration in adults. In this review, it is aimed to give information about the Hippo pathway, which we think has an important role in reversing the damage in adult mammalian heart tissue and in the development of new therapeutic targets, and its components.","PeriodicalId":272457,"journal":{"name":"Arşiv Kaynak Tarama Dergisi","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116724899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"First Step Evaluation of Patient with Foot and Ankle Injury","authors":"Mevlana Ömeroğlu","doi":"10.17827/aktd.905091","DOIUrl":"https://doi.org/10.17827/aktd.905091","url":null,"abstract":"","PeriodicalId":272457,"journal":{"name":"Arşiv Kaynak Tarama Dergisi","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131117924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"YENİ BİR HÜCRE ÖLÜM ŞEKLİ OLARAK FERROPTOZİS","authors":"Alper Çelenk","doi":"10.17827/aktd.980659","DOIUrl":"https://doi.org/10.17827/aktd.980659","url":null,"abstract":"","PeriodicalId":272457,"journal":{"name":"Arşiv Kaynak Tarama Dergisi","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114238181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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