Pub Date : 2022-11-09DOI: 10.51435/turkjac.1150201
Hakkı İsmail Kaya, Ceren Boguslu, Esra Kabak, Çağla Akkol, E. Saka, Selcen Celik Uzuner
Silicon (SiPcs) phthalocyanines are advantageous because they do not aggregate due to their special structural features. Therefore, they have been widely used in a range of areas in chemical and biological technology. One of the common applications is the use of phthalocyanines on cancer therapies. Pancreas cancer is one of the most common cancers with a high rate of mortality around the world. In this study we therefore aimed to investigate the potential of SiPcs molecules which we previously synthesized for the first time, on increased cell death and the effect on mitochondrial activity in pancreatic cancer cells. The results showed the significantly selective cytotoxic effect of SiPc on cancer cells compared to normal cells. Mitochondrial membrane potential was not different in cancer cells but in normal cells after SiPcs treatment. Pre-incubation time (24h) of SiPcs before light irradiation induced more significant cytotoxicity in pancreatic cancer cells but not in normal cells compared to prolonged pre-incubation (48). This study revisited the biological function of previously synthesized SiPcs, and the results conclude the cytotoxic activity of SiPcs on pancreas cancer. These preliminary findings can be extended for other cancer types and detailed with in vivo models in the future.
{"title":"The effect of silicon phthalocyanine on cell death and mitochondrial membrane potential in pancreatic cancer cells","authors":"Hakkı İsmail Kaya, Ceren Boguslu, Esra Kabak, Çağla Akkol, E. Saka, Selcen Celik Uzuner","doi":"10.51435/turkjac.1150201","DOIUrl":"https://doi.org/10.51435/turkjac.1150201","url":null,"abstract":"Silicon (SiPcs) phthalocyanines are advantageous because they do not aggregate due to their special structural features. Therefore, they have been widely used in a range of areas in chemical and biological technology. One of the common applications is the use of phthalocyanines on cancer therapies. Pancreas cancer is one of the most common cancers with a high rate of mortality around the world. In this study we therefore aimed to investigate the potential of SiPcs molecules which we previously synthesized for the first time, on increased cell death and the effect on mitochondrial activity in pancreatic cancer cells. The results showed the significantly selective cytotoxic effect of SiPc on cancer cells compared to normal cells. Mitochondrial membrane potential was not different in cancer cells but in normal cells after SiPcs treatment. Pre-incubation time (24h) of SiPcs before light irradiation induced more significant cytotoxicity in pancreatic cancer cells but not in normal cells compared to prolonged pre-incubation (48). This study revisited the biological function of previously synthesized SiPcs, and the results conclude the cytotoxic activity of SiPcs on pancreas cancer. These preliminary findings can be extended for other cancer types and detailed with in vivo models in the future.","PeriodicalId":274781,"journal":{"name":"Turkish Journal of Analytical Chemistry","volume":"173 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132839579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-18DOI: 10.51435/turkjac.1143144
T. Kar, S. Keleş, Z. Emir, K. Kaygusuz
Liquid yields achieved by fast pyrolysis of ligno-cellulosic biomass can be used in the production of chemical raw materials or as an energy source. Pyrolysis product yields generally depend on the type of biomass, temperature, retention time, heating rate, sweeping gas flow rate and particle size. In this study, fast pyrolysis of fig leaves selected as biomass was carried out in a fixed bed pyrolysis reactor. Fig leaves used in fast pyrolysis experiments in this study as an agricultural by-product can be obtained in large quantities from Turkey. In the experiments, the effect of temperature, entraining gas flow rate, and particle size on pyrolysis product yields were investigated. The experiments were carried out at 400, 500, 600, 700 °C, four different particle sizes. The highest liquid product yield was obtained at 600 C, while the heating rate was 200 cm3/min and the particle size was
{"title":"Fast pyrolysis of fig leaves: influence of pyrolysis parameters and characterization of bio-oil","authors":"T. Kar, S. Keleş, Z. Emir, K. Kaygusuz","doi":"10.51435/turkjac.1143144","DOIUrl":"https://doi.org/10.51435/turkjac.1143144","url":null,"abstract":"Liquid yields achieved by fast pyrolysis of ligno-cellulosic biomass can be used in the production of chemical raw materials or as an energy source. Pyrolysis product yields generally depend on the type of biomass, temperature, retention time, heating rate, sweeping gas flow rate and particle size. In this study, fast pyrolysis of fig leaves selected as biomass was carried out in a fixed bed pyrolysis reactor. Fig leaves used in fast pyrolysis experiments in this study as an agricultural by-product can be obtained in large quantities from Turkey. In the experiments, the effect of temperature, entraining gas flow rate, and particle size on pyrolysis product yields were investigated. The experiments were carried out at 400, 500, 600, 700 °C, four different particle sizes. The highest liquid product yield was obtained at 600 C, while the heating rate was 200 cm3/min and the particle size was","PeriodicalId":274781,"journal":{"name":"Turkish Journal of Analytical Chemistry","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115898182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-16DOI: 10.51435/turkjac.1124687
O. Canlı, B. Güzel, Kartal Çetintürk
Ethylenediaminetetraacetic acid (EDTA) is a chemical that is harmful to human health with its high solubility in water, which is used as a metal chelating agent in industries such as medicine, food, personal care product, agriculture. Thus, it is necessary to should be monitored in surface waters taken from dams supplying drinking and utility water. This work presents the applicability of the HPLC-UV/VIS system for the quantification of EDTA in surface waters based on the limit values of national and international legislation such as the Turkish Regulation on the Management of Surface Water Quality. The applicability of EDTA quantification in surface water was checked with validation study. The method validation consisted of selectivity, calibration curve linearity, limit of detection (LOD) and limit of quantification (LOQ), accuracy (recovery), and precision. In selectivity study, no peaks belonging to interfering compounds that would cause false-positive results were found in the chromatograms at the retention time of EDTA (5.773 min.). The linearity of EDTA was obtained ranging from 10 µg/L to 200 µg/L concentrations with the correlation coefficient of 0.9985 and the calibration curve equation of y=4659.4x-50223. The LOD and LOQ values of EDTA was 2.85 µg/L and 9.51 µg/L with the RSD of 5.36. In accuracy, the mean recovery of EDTA in surface water has been determined as 87.51 percent with an RSD of 6.11. The repeatability (RSD, %) varied from 5.44 % to 7.02 % with concentrations of 35.19 ± 1.91 μg/L and 17.11 ± 1.20 μg/L, whereas the reproducibility (RSD, %) was obtained at 3.45 % with the concentration of 34.13 ± 1.18 μg/L. In this study, the presence of EDTA was investigated in approximately 300 surface water samples and EDTA was found as positive in the concentration range of 11.17 µg/L to 52.14 µg/L in eleven real samples.
{"title":"Determination of Ethylenediaminetetraacetic acid (EDTA) levels in surface waters by high performance liquid chromatography (HPLC)-Ultraviolet/Visible (UV/VIS) detector","authors":"O. Canlı, B. Güzel, Kartal Çetintürk","doi":"10.51435/turkjac.1124687","DOIUrl":"https://doi.org/10.51435/turkjac.1124687","url":null,"abstract":"Ethylenediaminetetraacetic acid (EDTA) is a chemical that is harmful to human health with its high solubility in water, which is used as a metal chelating agent in industries such as medicine, food, personal care product, agriculture. Thus, it is necessary to should be monitored in surface waters taken from dams supplying drinking and utility water. This work presents the applicability of the HPLC-UV/VIS system for the quantification of EDTA in surface waters based on the limit values of national and international legislation such as the Turkish Regulation on the Management of Surface Water Quality. The applicability of EDTA quantification in surface water was checked with validation study. The method validation consisted of selectivity, calibration curve linearity, limit of detection (LOD) and limit of quantification (LOQ), accuracy (recovery), and precision. In selectivity study, no peaks belonging to interfering compounds that would cause false-positive results were found in the chromatograms at the retention time of EDTA (5.773 min.). The linearity of EDTA was obtained ranging from 10 µg/L to 200 µg/L concentrations with the correlation coefficient of 0.9985 and the calibration curve equation of y=4659.4x-50223. The LOD and LOQ values of EDTA was 2.85 µg/L and 9.51 µg/L with the RSD of 5.36. In accuracy, the mean recovery of EDTA in surface water has been determined as 87.51 percent with an RSD of 6.11. The repeatability (RSD, %) varied from 5.44 % to 7.02 % with concentrations of 35.19 ± 1.91 μg/L and 17.11 ± 1.20 μg/L, whereas the reproducibility (RSD, %) was obtained at 3.45 % with the concentration of 34.13 ± 1.18 μg/L. In this study, the presence of EDTA was investigated in approximately 300 surface water samples and EDTA was found as positive in the concentration range of 11.17 µg/L to 52.14 µg/L in eleven real samples.","PeriodicalId":274781,"journal":{"name":"Turkish Journal of Analytical Chemistry","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128283477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-14DOI: 10.51435/turkjac.1127473
Yunus Emre Kamiş, B. Akar, Cemallettin Baltaci
In this study, it was aimed to determine the physical, chemical and antioxidant properties of pomegranate sauces sold in the market in Turkey. A total of 18 pomegranate sauces were studied; 17 of which were purchased from the market, and one of them was produced in a rotary evaporator in the laboratory. For each sample, analysis of antioxidant activity, titratable acidity, brix, hydroxymethyl furfural, pH, color analysis, and sugar analyzes were performed. Antioxidant activity values were analyzed using 6 different methods (DPPH (2,2-diphenyl-1-picrylhydrazil) radical scavenging activity, ferric reducing antioxidant power (FRAP), ABTS●+ radical scavenging capacity, total antioxidant capacity assay (TAC), the total phenolic content (TPC) and total flavonoid content (TFC) methods). The lowest and highest values were determined for methods of DPPH (5.23- 2822.69 mg AA/kg), FRAP (57.94 - 2380.94 mg FeSO4/kg), TAC (660.47 - 3690.83 mg AA/kg), TFC (23.06 - 11680.71 mg QEE/kg), TPC (123.54 -9566.95 mg GAE/kg). Brix, pH and % titration acidity values varied between 70.00 - 76.70%, 1.66 -2.88, 2.65 -7.58%, respectively. In addition, HMF values were measured below the limit values in most of the samples, while these values were found to be high in some of the samples. The highest and lowest HMF values were measured between 4.58 -103.68 mg/kg, respectively. Many factors such as raw materials, additives, applied heat treatments, production processes and storage conditions are effective on produced pomegranate sauces. If the production conditions are regulated in accordance with the standards, the HMF values in pomegranate sauce will be below the limit.
{"title":"Determination of Physical, Chemical and Antioxidant Properties of Pomegranate Sauces Sold in The Market in Turkey","authors":"Yunus Emre Kamiş, B. Akar, Cemallettin Baltaci","doi":"10.51435/turkjac.1127473","DOIUrl":"https://doi.org/10.51435/turkjac.1127473","url":null,"abstract":"In this study, it was aimed to determine the physical, chemical and antioxidant properties of pomegranate sauces sold in the market in Turkey. A total of 18 pomegranate sauces were studied; 17 of which were purchased from the market, and one of them was produced in a rotary evaporator in the laboratory. For each sample, analysis of antioxidant activity, titratable acidity, brix, hydroxymethyl furfural, pH, color analysis, and sugar analyzes were performed. Antioxidant activity values were analyzed using 6 different methods (DPPH (2,2-diphenyl-1-picrylhydrazil) radical scavenging activity, ferric reducing antioxidant power (FRAP), ABTS●+ radical scavenging capacity, total antioxidant capacity assay (TAC), the total phenolic content (TPC) and total flavonoid content (TFC) methods). The lowest and highest values were determined for methods of DPPH (5.23- 2822.69 mg AA/kg), FRAP (57.94 - 2380.94 mg FeSO4/kg), TAC (660.47 - 3690.83 mg AA/kg), TFC (23.06 - 11680.71 mg QEE/kg), TPC (123.54 -9566.95 mg GAE/kg). Brix, pH and % titration acidity values varied between 70.00 - 76.70%, 1.66 -2.88, 2.65 -7.58%, respectively. In addition, HMF values were measured below the limit values in most of the samples, while these values were found to be high in some of the samples. The highest and lowest HMF values were measured between 4.58 -103.68 mg/kg, respectively. Many factors such as raw materials, additives, applied heat treatments, production processes and storage conditions are effective on produced pomegranate sauces. If the production conditions are regulated in accordance with the standards, the HMF values in pomegranate sauce will be below the limit.","PeriodicalId":274781,"journal":{"name":"Turkish Journal of Analytical Chemistry","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115733542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-07DOI: 10.51435/turkjac.1136876
F. Ağın, Gökçe Öztürk, D. Kul
The expectorant drug guaifenesin (GFN) electroanalytical analysis was performed on boron doped diamond electrode (BDDE) by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and square wave voltammetry (SWV) methods. The results of CV studies indicate that the reaction mechanism of GFN in the oxidation direction on the BDDE is irreversible and diffusion controlled. The linearity ranges are 0.400 ˗ 100 µM and 0.800 ˗ 100 µM for DPV and SWV methods, respectively. Limit of detection (LOD) values are obtained as 1.47 nM for DPV and 2.92 nM for SWV. Quantitative analysis of GFN from the pharmaceuticals was performed with fully validated DPV and SWV methods without any pre-separation. The sensitive methods with good recovery, high precision and accuracy have been developed for the electroanalytical analysis of GFN.
{"title":"Electroanalytical Analysis of Guaifenesin from Pharmaceuticals on Boron Doped Diamond Electrode","authors":"F. Ağın, Gökçe Öztürk, D. Kul","doi":"10.51435/turkjac.1136876","DOIUrl":"https://doi.org/10.51435/turkjac.1136876","url":null,"abstract":"The expectorant drug guaifenesin (GFN) electroanalytical analysis was performed on boron doped diamond electrode (BDDE) by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and square wave voltammetry (SWV) methods. The results of CV studies indicate that the reaction mechanism of GFN in the oxidation direction on the BDDE is irreversible and diffusion controlled. The linearity ranges are 0.400 ˗ 100 µM and 0.800 ˗ 100 µM for DPV and SWV methods, respectively. Limit of detection (LOD) values are obtained as 1.47 nM for DPV and 2.92 nM for SWV. Quantitative analysis of GFN from the pharmaceuticals was performed with fully validated DPV and SWV methods without any pre-separation. The sensitive methods with good recovery, high precision and accuracy have been developed for the electroanalytical analysis of GFN.","PeriodicalId":274781,"journal":{"name":"Turkish Journal of Analytical Chemistry","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127408555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-02DOI: 10.51435/turkjac.1132742
Nuray Denizhan, S. Yilmaz, G. Saglikoglu, E. Kilinc, Ç. Yengin, Fatma Gulay Der
Electrochemical reduction of triamcinolone acetonide on pencil graphite electrode surface was firstly investigated by cyclic voltammetry (CV). The dependence of cathodic peak current and peak potential on different pH medium and scan rate were investigated. The adsorption controlled nature of the peak was achieved. During pH optimization, 0.067 M Phosphate (pH 4.50 to pH 7.50), 0.2 M Acetate (pH 3.50 to 5.50) and 0.04 M Britton Robinson (BR; pH 2.00 to 12.00) buffers were employed as supporting electrolytes. Scan rate optimization was investigated in the range 25-1000 mVs-1 (vs. Ag/AgCl). Maximum peak current was observed in the 0.04 M BR buffer (pH 3.50). Peak current increases and shifts to more cathodic values with the increasing scan rate. Curve of logarithm of peak current (log I) versus logarithm of scan rate (log v) showed linear regression with the equation log(Ip/μA) = 0.8395 log(v/mVs-1)-0.8386 and correlation coefficient (R2: 0.9761). This indicated that slope of the logv-logI curve is close to 1.0 and the cathodic electrode reaction was adsorption controlled, as desirable. The linear range was 1×10-7-5×10-5 M, sensitivity was 1,3347 µA M-1, Limit of detection (LOD) and Limit of quantification (LOQ) were 3.18×10-8 M and 1.00×10-7 M, respectively. HPLC-PDA analysis were performed with H2O:MeOH (28:72, v/v) as mobile phases A and B at a flow rate of 1mL/min at 242nm. Method validation studies were conducted in accordance with ICH Q2(R1) guideline and corresponding results were summarized in tables. HPLC-PDA method displayed linearity in 0.1-50µg/mL (2.3×10-7-1.15×10-4 M) concentration range with LOD and LOQ values as 3.992×10-8 and 1.29×10-7M, respectively.
{"title":"Electrochemical investigation and liquid chromatographic analysis of triamcinolone acetonide in pharmaceutical formulations","authors":"Nuray Denizhan, S. Yilmaz, G. Saglikoglu, E. Kilinc, Ç. Yengin, Fatma Gulay Der","doi":"10.51435/turkjac.1132742","DOIUrl":"https://doi.org/10.51435/turkjac.1132742","url":null,"abstract":"Electrochemical reduction of triamcinolone acetonide on pencil graphite electrode surface was firstly investigated by cyclic voltammetry (CV). The dependence of cathodic peak current and peak potential on different pH medium and scan rate were investigated. The adsorption controlled nature of the peak was achieved. During pH optimization, 0.067 M Phosphate (pH 4.50 to pH 7.50), 0.2 M Acetate (pH 3.50 to 5.50) and 0.04 M Britton Robinson (BR; pH 2.00 to 12.00) buffers were employed as supporting electrolytes. Scan rate optimization was investigated in the range 25-1000 mVs-1 (vs. Ag/AgCl). Maximum peak current was observed in the 0.04 M BR buffer (pH 3.50). Peak current increases and shifts to more cathodic values with the increasing scan rate. Curve of logarithm of peak current (log I) versus logarithm of scan rate (log v) showed linear regression with the equation log(Ip/μA) = 0.8395 log(v/mVs-1)-0.8386 and correlation coefficient (R2: 0.9761). This indicated that slope of the logv-logI curve is close to 1.0 and the cathodic electrode reaction was adsorption controlled, as desirable. The linear range was 1×10-7-5×10-5 M, sensitivity was 1,3347 µA M-1, Limit of detection (LOD) and Limit of quantification (LOQ) were 3.18×10-8 M and 1.00×10-7 M, respectively. HPLC-PDA analysis were performed with H2O:MeOH (28:72, v/v) as mobile phases A and B at a flow rate of 1mL/min at 242nm. Method validation studies were conducted in accordance with ICH Q2(R1) guideline and corresponding results were summarized in tables. HPLC-PDA method displayed linearity in 0.1-50µg/mL (2.3×10-7-1.15×10-4 M) concentration range with LOD and LOQ values as 3.992×10-8 and 1.29×10-7M, respectively.","PeriodicalId":274781,"journal":{"name":"Turkish Journal of Analytical Chemistry","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132021345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-14DOI: 10.51435/turkjac.1119121
İrem Kirlangiç, K. V. Özdokur, F. Ertaş
Parkinson's disease (PD) is a degenerative disorder of the central nervous system. The motor symptoms of PD disease result from the death of dopamine-generating cells in a region of the mid brain and the dopamine precursor levodopa (L-Dopa) is used for the treatment. Carbidopa (Car) is administered in association with L-Dopa in pharmaceutical formulation as an inhibitor on the decarboxylase activity. Thus, their simultaneous determination is of great importance because of their co-existence in pharmaceutical preparations. Present study deals with a simple method development for simultaneous voltammetric determination of L-Dopa and Car at a pencil graphite electrode (PGE) via monitoring the reduction peak of L-Dopa and the second oxidation peak of Car. The sensitivity of the method was found comparable to other methods depending on the sophisticated electrode modifications and the limits of detection were calculated as sub micromolar levels.
{"title":"A Simple and High Throughput Methodology for Simultaneous Determination of Levodopa and Carbidopa","authors":"İrem Kirlangiç, K. V. Özdokur, F. Ertaş","doi":"10.51435/turkjac.1119121","DOIUrl":"https://doi.org/10.51435/turkjac.1119121","url":null,"abstract":"Parkinson's disease (PD) is a degenerative disorder of the central nervous system. The motor symptoms of PD disease result from the death of dopamine-generating cells in a region of the mid brain and the dopamine precursor levodopa (L-Dopa) is used for the treatment. Carbidopa (Car) is administered in association with L-Dopa in pharmaceutical formulation as an inhibitor on the decarboxylase activity. Thus, their simultaneous determination is of great importance because of their co-existence in pharmaceutical preparations. Present study deals with a simple method development for simultaneous voltammetric determination of L-Dopa and Car at a pencil graphite electrode (PGE) via monitoring the reduction peak of L-Dopa and the second oxidation peak of Car. The sensitivity of the method was found comparable to other methods depending on the sophisticated electrode modifications and the limits of detection were calculated as sub micromolar levels.","PeriodicalId":274781,"journal":{"name":"Turkish Journal of Analytical Chemistry","volume":"60 9-10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120914939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-14DOI: 10.51435/turkjac.1102045
A. Vural, A. Gündoğdu, F. Saka, V. Bulut, M. Soylak
In the study, physico-chemical parameters of Çit Stream and related creeks in Avliyana Basin (Gümüşhane, NE Turkey) were determined. In terms of physical parameters, it is seen that the Büyük Çit Stream has drinking water quality. According to piper diagram, all of the samples except one have fallen into region of class of CaCO3 and MgCO3 waters. The different one is the mixed water class. It has been determined that the metal content that may pose a risk to water is below the permissible limits. It has been seen that there may be only one point of risk for lead. As a result, physico-chemical aspect of water quality of Çit River and related creeks in Avliyana Basin has been seen to be suitable for drinking water standards.
本研究测定了土耳其东北部g m哈内Avliyana盆地Çit河及相关溪流的理化参数。从物性参数上看，b y k Çit小溪具有饮用水质。由piper图可知，除1个样品外，其余样品均落在CaCO3和MgCO3水类区域。另一种是混合水类。经测定，可能对水构成危险的金属含量低于允许的限度。已经看到，铅可能只有一个风险点。结果表明，Avliyana流域Çit河及相关小溪的理化水质符合饮用水标准。
{"title":"Geochemical investigation of the potability of surface water in Çit River and related creeks in Avliyana Basin (Gümüşhane, NE Turkey)","authors":"A. Vural, A. Gündoğdu, F. Saka, V. Bulut, M. Soylak","doi":"10.51435/turkjac.1102045","DOIUrl":"https://doi.org/10.51435/turkjac.1102045","url":null,"abstract":"In the study, physico-chemical parameters of Çit Stream and related creeks in Avliyana Basin (Gümüşhane, NE Turkey) were determined. In terms of physical parameters, it is seen that the Büyük Çit Stream has drinking water quality. According to piper diagram, all of the samples except one have fallen into region of class of CaCO3 and MgCO3 waters. The different one is the mixed water class. It has been determined that the metal content that may pose a risk to water is below the permissible limits. It has been seen that there may be only one point of risk for lead. As a result, physico-chemical aspect of water quality of Çit River and related creeks in Avliyana Basin has been seen to be suitable for drinking water standards.","PeriodicalId":274781,"journal":{"name":"Turkish Journal of Analytical Chemistry","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130442334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-14DOI: 10.51435/turkjac.1105730
Çiğdem Kanbeş Dindar
The electrochemical oxidation of famciclovir was investigated in pH range 2.0-10.0 using differential pulse voltammetry at boron-doped diamond electrode. The experimental results from pH and scan rate studies showed that the oxidation behavior of famciclovir at boron doped diamond electrode was irreversible and diffusion-controlled. Also, by using differential pulse technique at electrode, the anodic peak current is obtained to be linear over the range of concentration 0.5 µM - 12 µM and 6 µM - 100 µM in pH 4.7 acetate buffer solution (ABS) for standard drug solution and human serum, respectively. Limits of detection were 0.022 µM and 0.42 µM for standard drug solution and human serum, respectively. The repeatability, reproducibility, selectivity, precision and accuracy of developed method in all media were investigated and calculated. This method was successfully applied for the analysis of famciclovir human serum samples.
{"title":"ELECTROCHEMICAL DETERMINATION OF ANTIVIRAL DRUG FAMCICLOVIR IN HUMAN SERUM SAMPLES AT BORON-DOPED DIAMOND ELECTRODE","authors":"Çiğdem Kanbeş Dindar","doi":"10.51435/turkjac.1105730","DOIUrl":"https://doi.org/10.51435/turkjac.1105730","url":null,"abstract":"The electrochemical oxidation of famciclovir was investigated in pH range 2.0-10.0 using differential pulse voltammetry at boron-doped diamond electrode. The experimental results from pH and scan rate studies showed that the oxidation behavior of famciclovir at boron doped diamond electrode was irreversible and diffusion-controlled. Also, by using differential pulse technique at electrode, the anodic peak current is obtained to be linear over the range of concentration 0.5 µM - 12 µM and 6 µM - 100 µM in pH 4.7 acetate buffer solution (ABS) for standard drug solution and human serum, respectively. Limits of detection were 0.022 µM and 0.42 µM for standard drug solution and human serum, respectively. The repeatability, reproducibility, selectivity, precision and accuracy of developed method in all media were investigated and calculated. This method was successfully applied for the analysis of famciclovir human serum samples.","PeriodicalId":274781,"journal":{"name":"Turkish Journal of Analytical Chemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117157115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-06DOI: 10.51435/turkjac.1109562
Faruk Kardaş, H. Yüksek, Zafer Ocak
In this study, seven novel di-{2-ethoxy-6-[(3-substitue-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)azomethine]phenyl} terephtalates (4a-g) were synthesized from the rections of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2a-g) with di-(2-formyl-6-ethoxyphenyl) terephtalate (3). The compounds 4a-g were characterized using by IR, 1H-NMR, 13C-NMR and UV spectral data. In addition, 4 type compounds were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropanol, tert-butanol, dimethyl ketone, N,N-dimethylformamide and the half-neutralization potential values and the corresponding pKa values were determined for all cases.
{"title":"Synthesis and determination of acidity strength of some new di-{2-ethoxy-6-[(3-substitue-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)azomethine]phenyl} terephtalates","authors":"Faruk Kardaş, H. Yüksek, Zafer Ocak","doi":"10.51435/turkjac.1109562","DOIUrl":"https://doi.org/10.51435/turkjac.1109562","url":null,"abstract":"In this study, seven novel di-{2-ethoxy-6-[(3-substitue-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)azomethine]phenyl} terephtalates (4a-g) were synthesized from the rections of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2a-g) with di-(2-formyl-6-ethoxyphenyl) terephtalate (3). The compounds 4a-g were characterized using by IR, 1H-NMR, 13C-NMR and UV spectral data. In addition, 4 type compounds were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropanol, tert-butanol, dimethyl ketone, N,N-dimethylformamide and the half-neutralization potential values and the corresponding pKa values were determined for all cases.","PeriodicalId":274781,"journal":{"name":"Turkish Journal of Analytical Chemistry","volume":"95 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127097874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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