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Mathematical Modelling of Human Papillomavirus (HPV) Dynamics with Vaccination Incorporating Optimal Control Analysis 结合最优控制分析的人乳头瘤病毒(HPV)接种动力学数学模型
Pub Date : 2023-10-16 DOI: 10.9734/arjom/2023/v19i11751
Fednant O. Okware, Samuel B. Apima, Amos O. Wanjara
Human Papillomavirus (HPV) is an infectious illness with complex behavior that has had dangerous consequences in the society. In women, HPV is the leading cause of Cervical Cancer (CC). If not treated early, cervical cancer causes abnormal growth of the cervical walls, which leads to death. It is a threat, with half a million documented cases worldwide resulting in over 200 000 recorded deaths every year. In this research, we develop a mathematical model of HPV dynamics with vaccination and perform optimal control to reduce HPV and CC preventive expenses. The invariant region of the model solution was examined, and it was determined that the model was well posed and biologically meaningful. The feasibility of the model solution was examined, and it was discovered that the solution of the model remained positive in the feasible limited region (Omega). The disease equilibrium points were shown to exist. The basic reproduction number was examined and discovered to be the biggest eigenvalue of the next generation matrix. The local stability of the equilibrium points was investigated, and it was discovered that the disease free equilibrium and the endemic equilibrium points were asymptotically stable. The model was extended into optimal control, and their optimality system was derived analytically using the Pontryagin Maximum Principle. The optimality system was numerically solved using MATLAB software, and the graphs for various interventions were shown against time. Finally, the outcomes of this study suggest that when the three interventions (awareness, screening and treatment of HPV and CC, and vaccination) are combined, the infection begins to decrease considerably and eventually dies out in the community when the interventions are intensified.
人乳头瘤病毒(HPV)是一种具有复杂行为的传染性疾病,在社会上已经产生了危险的后果。在女性中,HPV是宫颈癌(CC)的主要原因。如果不及早治疗,宫颈癌会引起宫颈壁的异常生长,从而导致死亡。这是一种威胁,全世界每年有50万记录在案的病例,造成20多万人死亡。在这项研究中,我们建立了HPV接种动力学的数学模型,并进行了最优控制,以减少HPV和CC预防费用。对模型解的不变区域进行了检验,确定了该模型具有良好的定态性和生物学意义。对模型解的可行性进行了检验,发现模型解在可行极限区域(Omega)保持正解。疾病平衡点被证明是存在的。对基本再现数进行了检验,发现它是下一代矩阵的最大特征值。研究了平衡点的局部稳定性,发现无病平衡点和地方病平衡点是渐近稳定的。将该模型推广到最优控制中,利用庞特里亚金极大值原理解析导出了最优控制系统。利用MATLAB软件对优化系统进行了数值求解,并绘制了各干预措施随时间变化的曲线图。最后,本研究的结果表明,当三种干预措施(意识、HPV和CC的筛查和治疗以及疫苗接种)相结合时,感染开始大幅下降,并在干预措施加强时最终在社区中消失。
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引用次数: 0
Unveiling the Hidden Patterns: Exploring the Elusive Norm Attainability of Orthogonal Polynomials 揭示隐藏的模式:探索正交多项式难以捉摸的范数可达性
Pub Date : 2023-10-09 DOI: 10.9734/arjom/2023/v19i11749
Mogoi N. Evans, Isaac O. Okwany
This research paper delves into the intriguing realm of orthogonal polynomials, focusing on their ability to attain specific norm values and the conditions under which this phenomenon occurs. It explores various polynomial families, both classical and specialized, uncovering the unique characteristics that in uence norm attainability. Beyond theoretical insights, the paper delves into practical applications across multiple disciplines, offering new perspectives and problem-solving opportunities. By marrying rigorous mathematical analysis with real-world relevance, this research enriches our understanding of orthogonal polynomials while demonstrating their potential utility in diverse fields. It invites readers on a journey to unveil hidden patterns within this captivating mathematical domain.
本研究论文深入探讨了正交多项式的有趣领域,重点讨论了它们获得特定范数的能力以及这种现象发生的条件。它探讨了各种多项式族,包括经典的和专业的,揭示了影响范数可达性的独特特征。除了理论见解之外,论文还深入研究了跨多个学科的实际应用,提供了新的视角和解决问题的机会。通过将严谨的数学分析与现实世界的相关性相结合,本研究丰富了我们对正交多项式的理解,同时展示了正交多项式在不同领域的潜在效用。它邀请读者在这个迷人的数学领域揭开隐藏的模式之旅。
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引用次数: 0
A New Iterative Algorithm for Total Asymptotically Non-Expansive Mapping in CAT(0) Spaces CAT(0)空间中全渐近非扩张映射的一种新的迭代算法
Pub Date : 2023-10-09 DOI: 10.9734/arjom/2023/v19i11750
Samir Dashputre, Rakesh Tiwari, Jaynendra Shrivas
In this paper, we provide certain fixed point results for a total asymptotically non-expansive mapping, as well as a new iterative algorithm for approximating the fixed point of this class of mappings in the setting of CAT(0) spaces. Furthermore, we establish strong and (Delta)-converges theorem for total asymptotically non-expansive mapping in CAT(0) space. Our result, generalizes, improve, extend and unify the results of Thakur et al. [1], Izhar et al. [2] and many more in this direction.
本文给出了一类全渐近非扩张映射不动点的若干结果,以及在CAT(0)空间上逼近该类映射不动点的一种新的迭代算法。进一步,我们建立了CAT(0)空间中全渐近非扩张映射的强定理和(Delta) -收敛定理。我们的结果概括、改进、扩展和统一了Thakur等人[1]、Izhar等人[2]等人在这个方向上的结果。
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引用次数: 0
Properties and Convergence Analysis of Orthogonal Polynomials, Reproducing Kernels, and Bases in Hilbert Spaces Associated with Norm-Attainable Operators 与范数可得算子相关的希尔伯特空间中的正交多项式、再生核和基的性质和收敛性分析
Pub Date : 2023-10-09 DOI: 10.9734/arjom/2023/v19i11748
Mogoi N. Evans
This research paper delves into the properties and convergence behaviors of various sequences of orthogonal polynomials, reproducing kernels, and bases within Hilbert spaces governed by norm-attainable operators. Through rigorous analysis, the study establishes the completeness of the sequences of monic orthogonal polynomials and orthonormal polynomials, highlighting their comprehensive representation and approximation capabilities in the Hilbert space. The paper also demonstrates the completeness and density attributes of the sequence of normalized reproducing kernels, showcasing its effective role in capturing the intrinsic structure of the space. Additionally, the research investigates the uniform convergence of these sequences, revealing their convergence to essential operators within the Hilbert space. Ultimately, these results contribute to both theoretical understanding and practical applications in various fields by providing insights into function approximation and representation within this mathematical framework.
本文研究了由范数可得算子控制的希尔伯特空间中各种正交多项式序列、再生核序列和基序列的性质和收敛行为。通过严谨的分析,建立了单正交多项式和正交多项式序列的完备性,突出了它们在Hilbert空间中的综合表示和逼近能力。本文还论证了归一化再现核序列的完备性和密度属性,展示了归一化再现核序列在捕捉空间内在结构方面的有效作用。此外,研究了这些序列的一致收敛性,揭示了它们在Hilbert空间内对本质算子的收敛性。最终,这些结果通过在这个数学框架内提供对函数近似和表示的见解,有助于理论理解和在各个领域的实际应用。
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引用次数: 0
Some Common Fuzzy Fixed Point Theorems on G - Metric Space G -度量空间上一些常见的模糊不动点定理
Pub Date : 2023-09-27 DOI: 10.9734/arjom/2023/v19i10747
P. Senthil Kumar, P. Thiruveni
The motive of this paper is to give a few not unusual place constant factor theorems in G-Metric spaces, with the aid of using the perception of Common restrict with inside the variety belongings and to illustrate appropriate examples. These outcomes make bigger and generalizes numerous widely known outcomes with inside the literature.
本文的目的是在g -度量空间中利用公约束的概念,给出几个不稀奇的位置常数因子定理,并举例说明。这些结果扩大并概括了文献中许多广为人知的结果。
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引用次数: 0
Norm-Attainable Operators and Polynomials: Theory, Characterization, and Applications in Optimization and Functional Analysis 可达范数算子与多项式:理论、表征及在优化与泛函分析中的应用
Pub Date : 2023-09-25 DOI: 10.9734/arjom/2023/v19i10745
Mogoi N. Evans, Isaac O. Okwany
This research paper offers a comprehensive investigation into the concept of norm-attainability in Banach and Hilbert spaces. It establishes that norm-attainable operators exist if and only if the target space is a Banach space and that norm-attainable polynomials are inherently linear. In convex optimization scenarios, norm-attainable polynomials lead to unique global optima. The paper explores the norm of norm-attainable operators, revealing its connection to supremum norms. In Hilbert spaces, norm-attainable operators are self-adjoint. Additionally, it shows that in finite-dimensional spaces, all bounded linear operators are norm-attainable. The research also examines extremal polynomials and their relationship with derivative roots, characterizes optimal solutions in norm-attainable operator contexts, and explores equivalence between norm-attainable operators through invertible operators. In inner product spaces, norm-attainable polynomials are identified as constant. Lastly, it highlights the association between norm-attainable operators and convex optimization problems, where solutions lie on the unit ball's boundary. This paper offers a unified perspective with significant implications for functional analysis, operator theory, and optimization in various mathematical and scientific domains.
本文对Banach和Hilbert空间中范可达性的概念进行了全面的研究。证明了范数可得算子存在当且仅当目标空间是Banach空间,且范数可得多项式是固有线性的。在凸优化场景中,规范可达多项式导致唯一的全局最优。本文探讨了可得范数算子的范数,揭示了它与上范数的联系。在Hilbert空间中,范数可得算子是自伴随的。此外,还证明了在有限维空间中,所有有界线性算子都是范数可得的。研究还考察了极值多项式及其与导数根的关系,表征了范数可得算子背景下的最优解,并通过可逆算子探索了范数可得算子之间的等价性。在内积空间中,范数可得多项式被标识为常数。最后,强调了范数可达算子与凸优化问题之间的联系,其中解位于单位球的边界上。本文提供了一个统一的观点与显着含义的功能分析,算子理论,并在各种数学和科学领域的优化。
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引用次数: 0
Orthogonal Polynomials and Operator Convergence in Hilbert Spaces: Norm-Attainability, Uniform Boundedness, and Compactness 希尔伯特空间中的正交多项式和算子收敛:范数可达性、一致有界性和紧性
Pub Date : 2023-09-25 DOI: 10.9734/arjom/2023/v19i10744
Mogoi Evans
This research paper investigates the convergence properties of operators constructed from orthogonal polynomials in the context of Hilbert spaces. The study establishes norm-attainability and explores the uniform boundedness of these operators, extending the analysis to include complex-valued orthogonal polynomials. Additionally, the paper uncovers connections between operator compactness and the convergence behaviors of orthogonal polynomial operators, revealing how sequences of these operators converge weakly to both identity and zero operators. These results advance our understanding of the intricate interplay betweenalgebraic and analytical properties in Hilbert spaces, contributing to fields such as functional analysis and approximation theory. The research sheds new light on the fundamental connections underlying the behavior of operators defined by orthogonal polynomials in diverse Hilbert space settings.
本文研究了Hilbert空间中正交多项式构造算子的收敛性。本文建立了这些算子的范数可达性,并探讨了它们的一致有界性,将分析扩展到复值正交多项式。此外,本文还揭示了算子紧性与正交多项式算子收敛性之间的联系,揭示了正交多项式算子的序列如何弱收敛于单位算子和零算子。这些结果促进了我们对希尔伯特空间中代数和解析性质之间复杂相互作用的理解,有助于泛函分析和近似理论等领域。该研究揭示了不同希尔伯特空间设置中由正交多项式定义的算子行为的基本联系。
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引用次数: 0
Periodic Oscillation of the Solutions for a Parkinson's Disease Model 帕金森病模型解的周期振荡
Pub Date : 2023-09-22 DOI: 10.9734/arjom/2023/v19i10743
Chunhua Feng
In this paper, the oscillation of the solutions for a Parkinson's disease model with multiple delays is discussed. By linearizing the system at the equilibrium point and analyzing the instability of the linearized system, some sufficient conditions to guarantee the existence of periodic oscillation of the solutions for a delayed Parkinson's disease system are obtained. It is found that under suitable conditions on the parameters, time delay affects the stability of the system. The present method does not need to consider a bifurcating equation. Some numerical simulations are provided to illustrate our theoretical prediction.
本文讨论了一类具有多时滞的帕金森病模型解的振动性。通过在平衡点处对系统进行线性化,分析线性化后系统的不稳定性,得到了时滞帕金森病系统解存在周期振荡的充分条件。研究发现,在适当的参数条件下,时滞会影响系统的稳定性。本方法不需要考虑分岔方程。给出了一些数值模拟来说明我们的理论预测。
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引用次数: 0
On the Modeling of Causative and Dependence Relationship of Cancers based on Gender and Cumulative Incidence 基于性别和累积发病率的癌症因果关系模型研究
Pub Date : 2023-09-19 DOI: 10.9734/arjom/2023/v19i10742
Senyefia Bosson-Amedenu, Eric Justice Eduboah, Emmanuel Teku, Noureddine Ouerfelli, Ransford Ekow Baidoo
Objectives: The goal of our study was to model the causative relationship and dependence of morbidity, mortality, and cumulative incidence with respect to GLOBOCAN 2020 age standardized world estimates for female and male malignancies using two adjustable parameters having physical significance. Methods: The GLOBOCAN age standardized world estimates for patients for the year 2020 were used in this investigation. For the purposes of analyzing descriptive and analytical data, Kaleidagraph and Origin Software were employed. Bivariate empirical cross- correlation and dependency analyses were used to model how the variables were related to one another. The ratio of new cases to fatalities was calculated using equations comparing the stages of various malignancies. Results: In this work, the use of a two-state parameter resulted in the estimation of the optimal solution. The results demonstrated a non-linear correlation with a progressive increase when the cumulative risk of cancer death for each sex was examined separately versus the global cumulative risk of cancer mortality for both sexes. Males experienced the increase more dramatically than females. This finding suggests that the global male-to-female population ratio is not the only factor contributing to cumulative risk. Conclusion: South-Eastern Asia, out of all the regions of the world examined in this study, reached its inflection point at (16.23, 14.87). This generates the baseline and standard against which the overall risk of other countries can be measured. The global cumulative risk, which was estimated at 21.50 for females and 17.94 for males, respectively, dropped at this inflection point.
目的:本研究的目的是利用两个具有物理意义的可调参数,对GLOBOCAN 2020年龄标准化世界女性和男性恶性肿瘤的发病率、死亡率和累积发病率的因果关系和依赖性进行建模。 方法:本研究使用GLOBOCAN 2020年患者年龄标准化世界估计值。为了分析描述性和分析性数据,使用了Kaleidagraph和Origin软件。双变量经验相互关联和依赖分析被用来模拟变量如何相互关联。新病例与死亡的比率是用比较不同恶性肿瘤分期的公式计算出来的。结果:在这项工作中,使用双状态参数导致了最优解的估计。结果表明,当分别检查每个性别的癌症死亡累积风险与全球两种性别的癌症死亡累积风险时,两者之间存在非线性相关性。男性比女性的增幅更大。这一发现表明,全球男女人口比例并不是导致累积风险的唯一因素。结论:东南亚,在本研究调查的世界所有区域中,达到了它的拐点(16.23,14.87)。这就形成了衡量其他国家总体风险的基准和标准。全球累积风险,估计分别为21.50女性和17.94男性,在这个拐点下降。
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 Methods: The GLOBOCAN age standardized world estimates for patients for the year 2020 were used in this investigation. For the purposes of analyzing descriptive and analytical data, Kaleidagraph and Origin Software were employed. Bivariate empirical cross- correlation and dependency analyses were used to model how the variables were related to one another. The ratio of new cases to fatalities was calculated using equations comparing the stages of various malignancies.
 Results: In this work, the use of a two-state parameter resulted in the estimation of the optimal solution. The results demonstrated a non-linear correlation with a progressive increase when the cumulative risk of cancer death for each sex was examined separately versus the global cumulative risk of cancer mortality for both sexes. Males experienced the increase more dramatically than females. This finding suggests that the global male-to-female population ratio is not the only factor contributing to cumulative risk.
 Conclusion: South-Eastern Asia, out of all the regions of the world examined in this study, reached its inflection point at (16.23, 14.87). This generates the baseline and standard against which the overall risk of other countries can be measured. The global cumulative risk, which was estimated at 21.50 for females and 17.94 for males, respectively, dropped at this inflection point.","PeriodicalId":281529,"journal":{"name":"Asian Research Journal of Mathematics","volume":"134 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135013995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minimum Transversal Eccentric Dominating Energy of Graphs 图的最小横向偏心支配能
Pub Date : 2023-09-19 DOI: 10.9734/arjom/2023/v19i10741
None Riyaz Ur Rehman A., A. Mohamed Ismayil
For a graph G, the minimum transversal eccentric dominating energy (mathbb{E})(mathit{ted}) (G) is the sum of the eigenvalues obtained from the minimum transversal eccentric dominating (mathit{n}) x (mathit{n}) matrix (mathbb{M})(mathit{ted}) (G) = ((mathit{m})(mathit{ij})). In this paper (mathbb{E})(mathit{ted}) (G) of some standard graphs are computed. Properties, upper and lower bounds for (mathbb{E})(mathit{ted}) (G) are established.
对于图G,最小横偏心支配能量(mathbb{E})(mathit{ted}) (G)是由最小横偏心支配能量(mathit{n}) x (mathit{n})矩阵(mathbb{M})(mathit{ted}) (G) = ((mathit{m})(mathit{ij}))得到的特征值之和。本文计算了一些标准图的(mathbb{E})(mathit{ted}) (G)。建立了(mathbb{E})(mathit{ted}) (G)的性质及上界和下界。
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引用次数: 0
期刊
Asian Research Journal of Mathematics
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