Pub Date : 2019-11-26DOI: 10.1201/9780429316944-22
A. P. Ekeh
{"title":"A Multicenter Randomized Clinical Trial of Primary Anastomosis or Hartmann's Procedure for Perforated Left Colonic Diverticulitis with Purulent or Fecal Peritonitis","authors":"A. P. Ekeh","doi":"10.1201/9780429316944-22","DOIUrl":"https://doi.org/10.1201/9780429316944-22","url":null,"abstract":"","PeriodicalId":282445,"journal":{"name":"50 Landmark Papers","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115867582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-26DOI: 10.1201/9780429316944-29
Sarah Mathew, J. Barton, A. Ong
Clostridium difficile is a Gram-positive, anaerobic, spore-forming bacillus that is spread indirectly via the fecal-oral route through spores. Disturbance of gut microbiota due to antibiotic therapy causes abnormal proliferation of Clostridium difficile and toxin production, leading to the development of Clostridium difficile infection. A new, hyper-virulent strain of Clostridium difficile , NAP1/B1/027, has been implicated in Clostridium difficile outbreaks associated with increased morbidity and mortality since the early 2000s. In 2013, van Nood et al. reported that in patients with recurrent Clostridium difficile infection, fecal microbiota transplantation resulted in better treatment outcomes compared with conventional antibiotic treatment, which has attracted increased attention. Recently, monoclonal antibodies against toxin B, vaccines and a polystyrene binder of Clostridium difficile toxins have been developed for the treatment of Clostridium difficile infection. In this article, we will outline the epidemiology, pathophysiology, diagnosis and treatment of Clostridium difficile infection, and also describe the relationships between ulcerative colitis and Clostridium difficile infection.
{"title":"Clostridium difficile Infection","authors":"Sarah Mathew, J. Barton, A. Ong","doi":"10.1201/9780429316944-29","DOIUrl":"https://doi.org/10.1201/9780429316944-29","url":null,"abstract":"Clostridium difficile is a Gram-positive, anaerobic, spore-forming bacillus that is spread indirectly via the fecal-oral route through spores. Disturbance of gut microbiota due to antibiotic therapy causes abnormal proliferation of Clostridium difficile and toxin production, leading to the development of Clostridium difficile infection. A new, hyper-virulent strain of Clostridium difficile , NAP1/B1/027, has been implicated in Clostridium difficile outbreaks associated with increased morbidity and mortality since the early 2000s. In 2013, van Nood et al. reported that in patients with recurrent Clostridium difficile infection, fecal microbiota transplantation resulted in better treatment outcomes compared with conventional antibiotic treatment, which has attracted increased attention. Recently, monoclonal antibodies against toxin B, vaccines and a polystyrene binder of Clostridium difficile toxins have been developed for the treatment of Clostridium difficile infection. In this article, we will outline the epidemiology, pathophysiology, diagnosis and treatment of Clostridium difficile infection, and also describe the relationships between ulcerative colitis and Clostridium difficile infection.","PeriodicalId":282445,"journal":{"name":"50 Landmark Papers","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133482564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-26DOI: 10.1201/9780429316944-12
Raphael H. Parrado, D. Notrica
{"title":"Approach to Management of Intussusception in Adults: A New Paradigm in the Computed Tomography Era","authors":"Raphael H. Parrado, D. Notrica","doi":"10.1201/9780429316944-12","DOIUrl":"https://doi.org/10.1201/9780429316944-12","url":null,"abstract":"","PeriodicalId":282445,"journal":{"name":"50 Landmark Papers","volume":"110 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133752622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-26DOI: 10.1201/9780429316944-72
J. Benarroch‐Gampel, J. M. Chang
{"title":"The Society for Vascular Surgery Lower Extremity Threatened Limb Classification System: Risk Stratification Based on Wound, Ischemia, and Foot Infection (WIfI)","authors":"J. Benarroch‐Gampel, J. M. Chang","doi":"10.1201/9780429316944-72","DOIUrl":"https://doi.org/10.1201/9780429316944-72","url":null,"abstract":"","PeriodicalId":282445,"journal":{"name":"50 Landmark Papers","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133009763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-11-26DOI: 10.1201/9780429316944-44
E. Benjamin
{"title":"Comparison of Stapled Haemorrhoidopexy with Traditional Excisional Surgery for Haemorrhoidal Disease (eTHoS): A Pragmatic, Multicentre, Randomised Controlled Trial","authors":"E. Benjamin","doi":"10.1201/9780429316944-44","DOIUrl":"https://doi.org/10.1201/9780429316944-44","url":null,"abstract":"","PeriodicalId":282445,"journal":{"name":"50 Landmark Papers","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116171774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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