Pub Date : 2015-02-01DOI: 10.1109/ENBENG.2015.7088883
J. Fermeiro, M. Calado, I. Correia
The rapid growth of the world's population and the increase of human life expectancy has been leading to an increase in demand of organs for transplant. In the search for alternatives to overcome this shortage, Tissue Engineering research is leaning towards biotechnology in order to achieve mass production. Bioprinting is one of the most up-and-coming Tissue Engineering branches on the path to produce viable tissue for implantation, and it will be addressed and discussed in this work. Recent published works in this area have been showing good results, opening doors for a promising future. In the attempt to recreate the research in this area, a bioprinter was built with good resolution and precision for bioprinting testing. The bioprinter was built from ground up, with a simple design and with low cost materials, without compromising its capability.
{"title":"State of the art and challenges in bioprinting technologies, contribution of the 3D bioprinting in Tissue Engineering","authors":"J. Fermeiro, M. Calado, I. Correia","doi":"10.1109/ENBENG.2015.7088883","DOIUrl":"https://doi.org/10.1109/ENBENG.2015.7088883","url":null,"abstract":"The rapid growth of the world's population and the increase of human life expectancy has been leading to an increase in demand of organs for transplant. In the search for alternatives to overcome this shortage, Tissue Engineering research is leaning towards biotechnology in order to achieve mass production. Bioprinting is one of the most up-and-coming Tissue Engineering branches on the path to produce viable tissue for implantation, and it will be addressed and discussed in this work. Recent published works in this area have been showing good results, opening doors for a promising future. In the attempt to recreate the research in this area, a bioprinter was built with good resolution and precision for bioprinting testing. The bioprinter was built from ground up, with a simple design and with low cost materials, without compromising its capability.","PeriodicalId":285567,"journal":{"name":"2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134486991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2015-02-01DOI: 10.1109/ENBENG.2015.7088865
D. Oliveira, M. Parente, R. Jorge, B. Calvo, T. Mascarenhas
The childbirth process has been studied continuously and biomechanical models have been seen as quantitative analysis tools. The improvement of such models requires the characterization of the mechanical properties of the tissues involved. During vaginal delivery the muscles undergo large deformations and may suffer damage midway, therefore the definition of a constitutive model including damage process, as presented in this work, becomes critical. The performance of the constitutive model was tested with typical tridimensional simulations to assess the damage evolution. Although the accurate characterization of the mechanical properties is an extremely complex task, the model used seems to capture the typical stress-strain behavior observed in biological soft tissues during both loading-unloading test analysis. With the introduction of damage variables, the model can be also used in damage analysis being the damage evolution well reproduced. Further interpretation requires however extensive model validation using mechanical data on damage development.
{"title":"A structural damage model for pelvic floor muscles","authors":"D. Oliveira, M. Parente, R. Jorge, B. Calvo, T. Mascarenhas","doi":"10.1109/ENBENG.2015.7088865","DOIUrl":"https://doi.org/10.1109/ENBENG.2015.7088865","url":null,"abstract":"The childbirth process has been studied continuously and biomechanical models have been seen as quantitative analysis tools. The improvement of such models requires the characterization of the mechanical properties of the tissues involved. During vaginal delivery the muscles undergo large deformations and may suffer damage midway, therefore the definition of a constitutive model including damage process, as presented in this work, becomes critical. The performance of the constitutive model was tested with typical tridimensional simulations to assess the damage evolution. Although the accurate characterization of the mechanical properties is an extremely complex task, the model used seems to capture the typical stress-strain behavior observed in biological soft tissues during both loading-unloading test analysis. With the introduction of damage variables, the model can be also used in damage analysis being the damage evolution well reproduced. Further interpretation requires however extensive model validation using mechanical data on damage development.","PeriodicalId":285567,"journal":{"name":"2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG)","volume":"42 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123266572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-11-14DOI: 10.1109/ENBENG.2015.7088851
K. Bezerra, J. Machado, B. Silva, V. Carvalho, F. Soares, Demétrio Matos
The demographic changes demonstrate that the population is aging rapidly. The average life expectancy leads to the development of various diseases related to aging. The dependence and partial or total inability of a person to perform daily activities, requires a care plan to minimize the impact of their addiction. The main objective of assistance is to protect and care of fragile elders. Provide accesses to a walk-in or wheel chair accessible shower is essential for people with bathing disability. Bath is a fundamental action, referring to bedridden elder hygiene daily activities provided by caregivers. According to the context of care there must be provided particular attention to the skin of the elder. The contact of external means with this organ is one of the major concerns while designing this kind of devices as it can cause the thinning, drying and occasionally lesions and ulcers on the organ. This interdisciplinary concept project, on the domain of Ambient Assisted Living, consists in the conceptual design of a mechatronic system especially devoted to the assistance during the bath.
{"title":"Mechatronic system for assistance on bath of bedridden elderly people","authors":"K. Bezerra, J. Machado, B. Silva, V. Carvalho, F. Soares, Demétrio Matos","doi":"10.1109/ENBENG.2015.7088851","DOIUrl":"https://doi.org/10.1109/ENBENG.2015.7088851","url":null,"abstract":"The demographic changes demonstrate that the population is aging rapidly. The average life expectancy leads to the development of various diseases related to aging. The dependence and partial or total inability of a person to perform daily activities, requires a care plan to minimize the impact of their addiction. The main objective of assistance is to protect and care of fragile elders. Provide accesses to a walk-in or wheel chair accessible shower is essential for people with bathing disability. Bath is a fundamental action, referring to bedridden elder hygiene daily activities provided by caregivers. According to the context of care there must be provided particular attention to the skin of the elder. The contact of external means with this organ is one of the major concerns while designing this kind of devices as it can cause the thinning, drying and occasionally lesions and ulcers on the organ. This interdisciplinary concept project, on the domain of Ambient Assisted Living, consists in the conceptual design of a mechatronic system especially devoted to the assistance during the bath.","PeriodicalId":285567,"journal":{"name":"2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG)","volume":"226 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123096419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1109/enbeng.2015.7088825
Fatima C. Bastos, Sandra A. Lopes, Vanessa N. Corceiro, C. Matias, P. J. Mendes, F. S. D. Sampaio dos Aidos, J. Dionísio, R. Quinta-Ferreira, M. Quinta-Ferreira
The analysis of phenolic compounds pollution on health is a topic of major concern, in particular the effects associated with cellular damages. In central nervous system synapses zinc can be either a neuromodulator or a neurotoxin, depending on the intracellular concentration and may be implicated in various neurodegenerative diseases. The way phenolic compounds affect synaptic zinc thus contributes to the protective or toxic neuronal zinc changes that can be detected by means of fluorescent zinc indicators. This work focused on the influence of phenolic pollutants on postsynaptic zinc changes, including during chemically induced long term potentiation (LTP). The study was performed in hippocampal slices (400 μm), at the mossy fiber - CA3 pyramidal cells synaptic system, containing, in the synaptic vesicles, very high concentrations of loosely bound zinc. The slices, obtained from pregnant (16-18 days) Wistar rats (12-16 weeks old), were incubated during 1 h, in an oxygenated artificial cerebrospinal fluid (ACSF) containing 5 μM of the permeant fluorescent zinc probe Newport Green (Kd = 1 μM). The effect of a mixture of six phenolic pollutants (100 mg/L each) on the zinc signals was a reversible enhancement (35%, n = 2) indicating that those compounds activate intense zinc release followed by zinc entry in the postsynaptic area. The action of the compounds was also evaluated on the zinc changes associated with TEA-LTP, evoked subsequently by an ACSF solution containing TEA (25 mM) and high calcium (10 mM). It was found that the zinc signals measured in the modified ACFS, applied after the pollutants, have a similar behavior to that observed in control experiments, i.e. the signals decrease in a reversible way (to about 75 % of baseline, n = 3). This reduction, which may be due to the activation of presynaptic Katp channels, was observed both in the absence and following the application of the mixture of compounds, suggesting that mossy fiber TEA-LTP is not largely affected by the pollutants.
{"title":"Zinc changes evoked by phenolic compounds and effect on TEA-LTP at hippocampal mossy fiber synapses","authors":"Fatima C. Bastos, Sandra A. Lopes, Vanessa N. Corceiro, C. Matias, P. J. Mendes, F. S. D. Sampaio dos Aidos, J. Dionísio, R. Quinta-Ferreira, M. Quinta-Ferreira","doi":"10.1109/enbeng.2015.7088825","DOIUrl":"https://doi.org/10.1109/enbeng.2015.7088825","url":null,"abstract":"The analysis of phenolic compounds pollution on health is a topic of major concern, in particular the effects associated with cellular damages. In central nervous system synapses zinc can be either a neuromodulator or a neurotoxin, depending on the intracellular concentration and may be implicated in various neurodegenerative diseases. The way phenolic compounds affect synaptic zinc thus contributes to the protective or toxic neuronal zinc changes that can be detected by means of fluorescent zinc indicators. This work focused on the influence of phenolic pollutants on postsynaptic zinc changes, including during chemically induced long term potentiation (LTP). The study was performed in hippocampal slices (400 μm), at the mossy fiber - CA3 pyramidal cells synaptic system, containing, in the synaptic vesicles, very high concentrations of loosely bound zinc. The slices, obtained from pregnant (16-18 days) Wistar rats (12-16 weeks old), were incubated during 1 h, in an oxygenated artificial cerebrospinal fluid (ACSF) containing 5 μM of the permeant fluorescent zinc probe Newport Green (Kd = 1 μM). The effect of a mixture of six phenolic pollutants (100 mg/L each) on the zinc signals was a reversible enhancement (35%, n = 2) indicating that those compounds activate intense zinc release followed by zinc entry in the postsynaptic area. The action of the compounds was also evaluated on the zinc changes associated with TEA-LTP, evoked subsequently by an ACSF solution containing TEA (25 mM) and high calcium (10 mM). It was found that the zinc signals measured in the modified ACFS, applied after the pollutants, have a similar behavior to that observed in control experiments, i.e. the signals decrease in a reversible way (to about 75 % of baseline, n = 3). This reduction, which may be due to the activation of presynaptic Katp channels, was observed both in the absence and following the application of the mixture of compounds, suggesting that mossy fiber TEA-LTP is not largely affected by the pollutants.","PeriodicalId":285567,"journal":{"name":"2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124184174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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