Pub Date : 2020-11-27DOI: 10.56242/globalhealth;2020;1;1;64-69
Graciela Dos Santos Soares, Hannar Angélica de Melo Alverga, Giovana de Oliveira Dichman, Lucas Vinicius Morais, Dennis Minoru Fujita, C. França, Luiz Henrique Nali
OBJETIVE: Viruses are commonly associated with respiratory infections. Pandemics caused by respiratory viruses have affected humans considerably throughout history. We are currently facing a pandemic caused by SARS-CoV-2. Control measures the aimed to slow the virus spread may have interfered with the spread of other season respiratory viruses. Understanding the incidence of viral respiratory cases is necessary to corroborate this hypothesis. The aim of this study was to compare the incidences of the respiratory viruses that were reported in the weekly report of respiratory viruses between 2019 and 2020. METHODS: Epidemiological bulletins of 2019 and 2020 for cases of severe acute respiratory syndrome available at the Ministry of Health were consulted in order to determine the incidences of cases of viral respiratory infection, bulletins were considered for up to week 32. RESULTS: A substantial decrease was observed in cases of Severe Acute Respiratory Syndrome related to respiratory viruses other than SARS-CoV-2, suggesting that pandemic-related control in progress can affect the circulation of other respiratory viruses, since transmission of these viruses is very similar and protected measures such as social distance and an increase in the level of personal hygiene can be effective in reducing the spread of most of them. In addition, the closure of school units during the period of greatest incidence of respiratory viruses may have contributed to the decrease in cases among children. CONCLUSION: The measures adopted may have influenced considerably in the spread of other respiratory viruses.
{"title":"INCIDENCE OF OTHER RESPIRATORY VIRUSES IN BRAZIL DURING SARS-COV2 PANDEMIC","authors":"Graciela Dos Santos Soares, Hannar Angélica de Melo Alverga, Giovana de Oliveira Dichman, Lucas Vinicius Morais, Dennis Minoru Fujita, C. França, Luiz Henrique Nali","doi":"10.56242/globalhealth;2020;1;1;64-69","DOIUrl":"https://doi.org/10.56242/globalhealth;2020;1;1;64-69","url":null,"abstract":"OBJETIVE: Viruses are commonly associated with respiratory infections. Pandemics caused by respiratory viruses have affected humans considerably throughout history. We are currently facing a pandemic caused by SARS-CoV-2. Control measures the aimed to slow the virus spread may have interfered with the spread of other season respiratory viruses. Understanding the incidence of viral respiratory cases is necessary to corroborate this hypothesis. The aim of this study was to compare the incidences of the respiratory viruses that were reported in the weekly report of respiratory viruses between 2019 and 2020. METHODS: Epidemiological bulletins of 2019 and 2020 for cases of severe acute respiratory syndrome available at the Ministry of Health were consulted in order to determine the incidences of cases of viral respiratory infection, bulletins were considered for up to week 32. RESULTS: A substantial decrease was observed in cases of Severe Acute Respiratory Syndrome related to respiratory viruses other than SARS-CoV-2, suggesting that pandemic-related control in progress can affect the circulation of other respiratory viruses, since transmission of these viruses is very similar and protected measures such as social distance and an increase in the level of personal hygiene can be effective in reducing the spread of most of them. In addition, the closure of school units during the period of greatest incidence of respiratory viruses may have contributed to the decrease in cases among children. CONCLUSION: The measures adopted may have influenced considerably in the spread of other respiratory viruses.","PeriodicalId":285800,"journal":{"name":"Brazilian Journal of Global Health","volume":"121 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115914247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-27DOI: 10.56242/globalhealth;2020;1;1;35-41
Renan Germano, Gustavo Couto Fernandes, Tabatah Hellen Gomes Santos, Luiz Henrique da Silva Nali, Carolina Nunes França, Lucas Melo Neves
OBJETIVO: Verificar se o exercício físico é efetivo para melhoria na composição corporal, colesterol total e triglicérides de pacientes com HIV. MÉTODOS: o presente estudo trata-se de uma revisão sistemática com meta-análise com objetivo de investigar os efeitos de programas de exercícios de força e/ou aeróbios em portadores do vírus HIV na composição corporal, colesterol total e triglicérides. Está registrado na plataforma PROSPERO (International prospective register of systematic reviews) sob número CRD42016043451. Adotou-se a estratégia de pesquisa PICOS, selecionando os principais MeSH terms para a busca nas plataformas Embase, Pubmed e Web of Science. Os resultados foram tabulados, selecionados quanto sua relevância e classificados em relação aos riscos de viés. RESULTADOS: 10 estudos foram selecionados. Apesar de diversos estudos individualmente apontarem para a melhoria nas variáveis investigadas, estatística meta-analítica não apontou significância para as variáveis de composição corporal (gordura corporal e visceral, IMC, RCQ, massa magra) e colesterol total, porém na variável triglicérides verificou-se mudança significante com tamanho de efeito (TE) grande (TE1.36 [0.28, 2.44]. CONCLUSÃO: O exercício de força e o exercício aeróbio, realizados de maneira isolada ou combinada, são efetivos para melhoria significante da variável triglicérides de pacientes portadores do vírus HIV sob o tratamento de terapias antirretrovirais de alta atividade.
目的:验证体育锻炼是否能有效改善HIV患者的身体成分、总胆固醇和甘油三酯。方法:本研究是一项系统综述和荟萃分析，旨在调查力量和/或有氧运动计划对艾滋病毒携带者身体成分、总胆固醇和甘油三酯的影响。它在PROSPERO平台(国际前瞻性系统评论注册)注册，编号为CRD42016043451。采用PICOS搜索策略，在Embase、Pubmed和Web of Science平台上选择主要的MeSH术语进行搜索。结果被制成表格，根据其相关性进行选择，并根据偏倚风险进行分类。结果:选取10项研究。尽管个人研究表明在改善统计调查,目标-analítica不变量意义指着身体成分变量(身体脂肪和内脏,bmi RCQ瘦变量)和总胆固醇,甘油三酯和规模发生重大变化(你)大(TE1.36[0。8)。结论:单独或联合进行力量运动和有氧运动对高活性抗逆转录病毒治疗的HIV患者的可变甘油三酯有显著改善作用。
{"title":"EXERCÍCIO FÍSICO, COMPOSIÇÃO CORPORAL, COLESTEROL E TRIGLICÉRIDES NO PACIENTE COM HIV: UMA META-ANÁLISE","authors":"Renan Germano, Gustavo Couto Fernandes, Tabatah Hellen Gomes Santos, Luiz Henrique da Silva Nali, Carolina Nunes França, Lucas Melo Neves","doi":"10.56242/globalhealth;2020;1;1;35-41","DOIUrl":"https://doi.org/10.56242/globalhealth;2020;1;1;35-41","url":null,"abstract":"OBJETIVO: Verificar se o exercício físico é efetivo para melhoria na composição corporal, colesterol total e triglicérides de pacientes com HIV. MÉTODOS: o presente estudo trata-se de uma revisão sistemática com meta-análise com objetivo de investigar os efeitos de programas de exercícios de força e/ou aeróbios em portadores do vírus HIV na composição corporal, colesterol total e triglicérides. Está registrado na plataforma PROSPERO (International prospective register of systematic reviews) sob número CRD42016043451. Adotou-se a estratégia de pesquisa PICOS, selecionando os principais MeSH terms para a busca nas plataformas Embase, Pubmed e Web of Science. Os resultados foram tabulados, selecionados quanto sua relevância e classificados em relação aos riscos de viés. RESULTADOS: 10 estudos foram selecionados. Apesar de diversos estudos individualmente apontarem para a melhoria nas variáveis investigadas, estatística meta-analítica não apontou significância para as variáveis de composição corporal (gordura corporal e visceral, IMC, RCQ, massa magra) e colesterol total, porém na variável triglicérides verificou-se mudança significante com tamanho de efeito (TE) grande (TE1.36 [0.28, 2.44]. CONCLUSÃO: O exercício de força e o exercício aeróbio, realizados de maneira isolada ou combinada, são efetivos para melhoria significante da variável triglicérides de pacientes portadores do vírus HIV sob o tratamento de terapias antirretrovirais de alta atividade.","PeriodicalId":285800,"journal":{"name":"Brazilian Journal of Global Health","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121553123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-27DOI: 10.56242/globalhealth;2020;1;1;6-11
Andre Luis Lacerda Bachi, Juliana de Melo Batista dos Santos, Fernanda Rodrigues Monteiro, Marcelo N. Rossi, Jônatas Bussador do Amaral, Camila Pereira Soares, Camila Araújo Valério, Vanessa Nascimento Chalup, Gabriela Fernandes Leite, F. Almeida, Marco Aurélio Palazzi Sáfadi, B. Nobre Monteiro Paiatto, Anna Carlota Mott Barrientos, Aline Graça Fevereiro, Milena De Paulis, Lilian Ferri Passadore, Theresa Ramalho, Rodolfo de Paula Vieira, E. Durigon, Danielle Bruna Leal Oliveira, Norma de Oliveira Penido
OBJECTIVE: COVID-19 is a systemic disease affecting multiple organs, beyond the respiratory system. Although sensorineural symptoms, including anosmia and ageusia, have been frequently associated with milder forms of SARS-CoV-2 infection, the pathogenic mechanism and its relation with oromucosal immunomodulation remains poorly understood. Therefore, the main objective of this pilot study was to provide some pieces of evidence concerning the cytokines pattern in the mucosa of the upper airways in COVID-19 patients with and without anosmia and/or ageusia. METHODS: Samples of nasopharyngeal/oropharyngeal swabs were obtained from 12 patients diagnosed with COVID-19. The patients were separated into two groups: with anosmia and/or ageusia (A/A,n=4), and a control group with patients without anosmia and/or ageusia (NA/A,n=8). RESULTS: Mucosal cytokines concentration was determined by ELISA. Levels of IFN-γ, IL-6, and IL-10 in the mucosa of the upper airways were similar between the groups. In addition, no significant differences were found in the ratio of IFN-γ/IL-6, IFN-γ/IL-10, and IL-10/IL-6 between the two groups. However, using Pearson's correlation coefficient we found a significant positive correlations between IL-6 and IFN-γ, IL-10 and IFN-γ, and also IL-10 and IL-6 in the control group (NA/A), whereas a significant negative correlation between IL-10 and IFN-γ was found in A/A group. CONCLUSION: Our results suggest that patients with mild forms of COVID-19, presenting anosmia and/or ageusia, have an altered mucosal immune response in the upper airways. DESCRIPTORS: SARS-CoV-2, Sensorineural symptoms, IL-6, IL-10, IFN-gamma.
{"title":"ANOSMIA AND AGEUSIA IN COVID-19 PATIENTS: THE CYTOKINES PROFILE IN UPPER AIRWAYS","authors":"Andre Luis Lacerda Bachi, Juliana de Melo Batista dos Santos, Fernanda Rodrigues Monteiro, Marcelo N. Rossi, Jônatas Bussador do Amaral, Camila Pereira Soares, Camila Araújo Valério, Vanessa Nascimento Chalup, Gabriela Fernandes Leite, F. Almeida, Marco Aurélio Palazzi Sáfadi, B. Nobre Monteiro Paiatto, Anna Carlota Mott Barrientos, Aline Graça Fevereiro, Milena De Paulis, Lilian Ferri Passadore, Theresa Ramalho, Rodolfo de Paula Vieira, E. Durigon, Danielle Bruna Leal Oliveira, Norma de Oliveira Penido","doi":"10.56242/globalhealth;2020;1;1;6-11","DOIUrl":"https://doi.org/10.56242/globalhealth;2020;1;1;6-11","url":null,"abstract":"OBJECTIVE: COVID-19 is a systemic disease affecting multiple organs, beyond the respiratory system. Although sensorineural symptoms, including anosmia and ageusia, have been frequently associated with milder forms of SARS-CoV-2 infection, the pathogenic mechanism and its relation with oromucosal immunomodulation remains poorly understood. Therefore, the main objective of this pilot study was to provide some pieces of evidence concerning the cytokines pattern in the mucosa of the upper airways in COVID-19 patients with and without anosmia and/or ageusia. METHODS: Samples of nasopharyngeal/oropharyngeal swabs were obtained from 12 patients diagnosed with COVID-19. The patients were separated into two groups: with anosmia and/or ageusia (A/A,n=4), and a control group with patients without anosmia and/or ageusia (NA/A,n=8). RESULTS: Mucosal cytokines concentration was determined by ELISA. Levels of IFN-γ, IL-6, and IL-10 in the mucosa of the upper airways were similar between the groups. In addition, no significant differences were found in the ratio of IFN-γ/IL-6, IFN-γ/IL-10, and IL-10/IL-6 between the two groups. However, using Pearson's correlation coefficient we found a significant positive correlations between IL-6 and IFN-γ, IL-10 and IFN-γ, and also IL-10 and IL-6 in the control group (NA/A), whereas a significant negative correlation between IL-10 and IFN-γ was found in A/A group. CONCLUSION: Our results suggest that patients with mild forms of COVID-19, presenting anosmia and/or ageusia, have an altered mucosal immune response in the upper airways. DESCRIPTORS: SARS-CoV-2, Sensorineural symptoms, IL-6, IL-10, IFN-gamma.","PeriodicalId":285800,"journal":{"name":"Brazilian Journal of Global Health","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127881762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-27DOI: 10.56242/globalhealth;2020;1;1;47-51
Angela Maria de Sousa Freitas Meneses, Amanda Gomes Torres, Kayo Henrique Jardel Feitosa Sousa, Irene Maria da Silva Oliveira, Camila Aparecida Pinheiro Landim Almeida
OBJECTIVE: To describe the sociodemographic and clinical aspects of women with breast cancer treated at a hospital. METHODS: Documentary, descriptive and quantitative study, carried out in a referral hospital unit for the care of people with breast cancer, in Northeastern Brazil. 79 charts of women with breast cancer were analyzed. A form was used that included socio-demographic, clinical and health-related aspects. The data were submitted to descriptive analysis using the BioEstat 3.0 Program. RESULTS: Approximately 66% are in the 41 to 60 age group. Reproductive characteristics showed that 12.66% of women started menarche from the age of 10, 31 had at least one type of disease identified: hypertension 13 (56.5%), diabetes mellitus 7 (30.4%), allergy 5 (21.7%). Mastectomy was the most frequent surgery (63.2%). The empirical findings reported in this study showed that 30.4% had diabetes mellitus and 56% hypertension. Family history was determined to be an important risk factor for the development of breast cancer. CONCLUSION: The results can be subsidies for the development of larger studies related to the theme, which makes it possible to contribute to increase the visibility of public agencies and health services.
{"title":"CARACTERIZAÇÃO DE MULHERES COM CANCRO DA MAMA ATENDIDAS EM UMA UNIDADE HOSPITALAR","authors":"Angela Maria de Sousa Freitas Meneses, Amanda Gomes Torres, Kayo Henrique Jardel Feitosa Sousa, Irene Maria da Silva Oliveira, Camila Aparecida Pinheiro Landim Almeida","doi":"10.56242/globalhealth;2020;1;1;47-51","DOIUrl":"https://doi.org/10.56242/globalhealth;2020;1;1;47-51","url":null,"abstract":"OBJECTIVE: To describe the sociodemographic and clinical aspects of women with breast cancer treated at a hospital. METHODS: Documentary, descriptive and quantitative study, carried out in a referral hospital unit for the care of people with breast cancer, in Northeastern Brazil. 79 charts of women with breast cancer were analyzed. A form was used that included socio-demographic, clinical and health-related aspects. The data were submitted to descriptive analysis using the BioEstat 3.0 Program. RESULTS: Approximately 66% are in the 41 to 60 age group. Reproductive characteristics showed that 12.66% of women started menarche from the age of 10, 31 had at least one type of disease identified: hypertension 13 (56.5%), diabetes mellitus 7 (30.4%), allergy 5 (21.7%). Mastectomy was the most frequent surgery (63.2%). The empirical findings reported in this study showed that 30.4% had diabetes mellitus and 56% hypertension. Family history was determined to be an important risk factor for the development of breast cancer. CONCLUSION: The results can be subsidies for the development of larger studies related to the theme, which makes it possible to contribute to increase the visibility of public agencies and health services.","PeriodicalId":285800,"journal":{"name":"Brazilian Journal of Global Health","volume":"139 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114757003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-27DOI: 10.56242/globalhealth;2020;1;1;21-28
Maria Alheli Cab-Romero, Andréa Pereira da Costa, Jaciara de Oliveira Jorge Costa, Ingridi Braz de Oliveira Manhães, Ryan Emiliano da Silva, H. Ruiz-Piña, E. Reyes‐Novelo, Javier Escobedo-Ortegona, R. Tonhosolo, A. Marcili
OBJECTIVE: Trypanosoma cruzi comprises highly heterogeneus populations classified within six Discrete Typing Unit (DTU´s) named Tc-I to Tc-VI ans TcBat. Evolutionary history of T. cruzi has a very strong association with their mammal hosts and some phylogenetic and ecolobiologically studies suggest that ecotopes, hosts and vectors are factors that determine the different lineages of T. cruzi. METHODS: Herein we characterized T. cruzi isolates from synanthropic individuals of Didelphis virginiana and Rattus rattus captured in the village of Molas, Yucatan. RESULTS: Forty households were selected and traps were placed in the yard during January to May of 2014. Sixty six opossum (Didelphis virginiana) and twenty five rats (Rattus rattus) were captured and 13 were diagnosed as T. cruzi infected by microhematocrit and blood culture. Ten isolates of T. cruzi were obtained for phylogenetic analysis with SSU rDNA, gGAPDH and Cytochrome B genes to describe the relationships between them and classify them into the different DTU´s. CONCLUSION: This study demonstrated the participation of synanthropic animals D. virginiana and R. rattus as a reservoirs of T. cruzi in Yucatan_Mexico and the different isolates of the parasite belonged to Tc-I. The proximity of these species to the domestic environment favor the contact of the trypanosome with the human population in domestic environment.
{"title":"SYNANTHROPIC MAMMALS IN TRANSMISSION CYCLE OF TRYPANOSOMA CRUZI IN YUCATÁN, MEXICO","authors":"Maria Alheli Cab-Romero, Andréa Pereira da Costa, Jaciara de Oliveira Jorge Costa, Ingridi Braz de Oliveira Manhães, Ryan Emiliano da Silva, H. Ruiz-Piña, E. Reyes‐Novelo, Javier Escobedo-Ortegona, R. Tonhosolo, A. Marcili","doi":"10.56242/globalhealth;2020;1;1;21-28","DOIUrl":"https://doi.org/10.56242/globalhealth;2020;1;1;21-28","url":null,"abstract":"OBJECTIVE: Trypanosoma cruzi comprises highly heterogeneus populations classified within six Discrete Typing Unit (DTU´s) named Tc-I to Tc-VI ans TcBat. Evolutionary history of T. cruzi has a very strong association with their mammal hosts and some phylogenetic and ecolobiologically studies suggest that ecotopes, hosts and vectors are factors that determine the different lineages of T. cruzi. METHODS: Herein we characterized T. cruzi isolates from synanthropic individuals of Didelphis virginiana and Rattus rattus captured in the village of Molas, Yucatan. RESULTS: Forty households were selected and traps were placed in the yard during January to May of 2014. Sixty six opossum (Didelphis virginiana) and twenty five rats (Rattus rattus) were captured and 13 were diagnosed as T. cruzi infected by microhematocrit and blood culture. Ten isolates of T. cruzi were obtained for phylogenetic analysis with SSU rDNA, gGAPDH and Cytochrome B genes to describe the relationships between them and classify them into the different DTU´s. CONCLUSION: This study demonstrated the participation of synanthropic animals D. virginiana and R. rattus as a reservoirs of T. cruzi in Yucatan_Mexico and the different isolates of the parasite belonged to Tc-I. The proximity of these species to the domestic environment favor the contact of the trypanosome with the human population in domestic environment.","PeriodicalId":285800,"journal":{"name":"Brazilian Journal of Global Health","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131835609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-27DOI: 10.56242/globalhealth;2020;1;1;16-20
Jean Cortez Bettencourt, Jônatas Bussador do Amaral, C. Nunes França, A. Bachi
OBJECTIVE: Although it is known that the tumor microenvironment (TME) is composed of a heterogeneous group of cells, which includes tumor cells, as well as non-tumor cells, such as stromal cells associated with the tumor and some leukocytes types, the objective of this systematic review was to provide updated information on the participation of non-tumor cells present in the TME on tumor progression of head and neck cancers. METHODS: A bibliographic review was carried out, through an online search between May and October 2020, of scientific articles published in Portuguese and English between 2002 and 2020 in the public health databases: LILACS, SCIELO, PubMed, and Google Scholar, following the question guiding: what is the role of non-tumor cells present in the TME in the progression of head and neck cancer?, and using the descriptors: neoplasia; tumor microenvironment; head and neck cancer; infiltrating tumor cells; stromal cells; fibroblast; leukocytes; T lymphocytes; macrophages, myeloid-derived suppressor cells. RESULTS: Initially 158 articles were selected, of which 60 were excluded because they were duplicated, 58 because they did not address the theme of the study, and 18 because they did not answer the guiding question. Thus, 22 studies were used in this review. CONCLUSION: TME is a specific tumor site where there is an intense interaction between molecules and cells and, in general, the non-tumor cells present in the TME, both fibroblasts, a stromal cell, and leukocytes act favoring the progression of head and neck cancer.
{"title":"NON-TUMOR CELLS ROLE IN THE TUMOR MICROENVIRONMENT (TME) OF HEAD AND NECK CANCER (HNC)","authors":"Jean Cortez Bettencourt, Jônatas Bussador do Amaral, C. Nunes França, A. Bachi","doi":"10.56242/globalhealth;2020;1;1;16-20","DOIUrl":"https://doi.org/10.56242/globalhealth;2020;1;1;16-20","url":null,"abstract":"OBJECTIVE: Although it is known that the tumor microenvironment (TME) is composed of a heterogeneous group of cells, which includes tumor cells, as well as non-tumor cells, such as stromal cells associated with the tumor and some leukocytes types, the objective of this systematic review was to provide updated information on the participation of non-tumor cells present in the TME on tumor progression of head and neck cancers. METHODS: A bibliographic review was carried out, through an online search between May and October 2020, of scientific articles published in Portuguese and English between 2002 and 2020 in the public health databases: LILACS, SCIELO, PubMed, and Google Scholar, following the question guiding: what is the role of non-tumor cells present in the TME in the progression of head and neck cancer?, and using the descriptors: neoplasia; tumor microenvironment; head and neck cancer; infiltrating tumor cells; stromal cells; fibroblast; leukocytes; T lymphocytes; macrophages, myeloid-derived suppressor cells. RESULTS: Initially 158 articles were selected, of which 60 were excluded because they were duplicated, 58 because they did not address the theme of the study, and 18 because they did not answer the guiding question. Thus, 22 studies were used in this review. CONCLUSION: TME is a specific tumor site where there is an intense interaction between molecules and cells and, in general, the non-tumor cells present in the TME, both fibroblasts, a stromal cell, and leukocytes act favoring the progression of head and neck cancer.","PeriodicalId":285800,"journal":{"name":"Brazilian Journal of Global Health","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131042434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-27DOI: 10.56242/globalhealth;2020;1;1;57-60
Giovana Scachetti, O. Person, Beatriz Gregio Soares, Rafael Porpino, P. Bogar, Fernando Veiga Angélico Júnior
OBJECTIVE: The purpose is to evaluate the effectiveness and safety of intranasal cinnamon extract (CE) in the management of patients with allergic rhinitis (AR). METHODS: This is a systematic review, using the standard methodological procedures recommended by Cochrane to search six databases: Cochrane, PUBMED, EMBASE and LILACS, from database inception up to May 2020, to identify randomized controlled trials evaluating the use of CE in treatment for AR. RESULTS: We included two trials involving a total of 100 participants. The studies were at low risk of bias. All studies had similar participant selection criteria and outcome measurement, enabling a meta-analysis. Both studies used a validated instrument (Rhinoconjunctivitis quality of life questionnaire – RQLQ) for this primary outcome (SMD -1.06; 95% confidence interval (CI) -1.58 to -0.59, P <0.0001). . All studies resulted in at least some clinical benefit with the use of CE compared to placebo. None of the included studies reported any significant adverse effects. CONCLUSION: Despite the evidence from two studies showed certain positive effects of response for CE under evaluation in treatment of AR. We found no evidence regarding the effectiveness of cinnamon bark extract for allergic rhinitis. Well-conducted randomized clinical trials using CE are needed to further advance our understanding of the effectiveness of AR.
目的:评价鼻内肉桂提取物(CE)治疗变应性鼻炎(AR)患者的有效性和安全性。方法:这是一项系统综述，使用Cochrane推荐的标准方法程序检索六个数据库:Cochrane、PUBMED、EMBASE和LILACS，从数据库建立到2020年5月，以确定评估CE在AR治疗中使用的随机对照试验。结果:我们纳入了两项试验，共涉及100名参与者。这些研究的偏倚风险较低。所有的研究都有相似的参与者选择标准和结果测量，因此可以进行荟萃分析。两项研究都使用了一种经过验证的工具(鼻结膜炎生活质量问卷- RQLQ)来评估这一主要结局(SMD -1.06;95%置信区间(CI) -1.58 ~ -0.59, P <0.0001)。所有的研究结果表明，与安慰剂相比，使用CE至少有一些临床益处。纳入的研究均未报告任何显著的不良反应。结论:尽管有两项研究的证据表明CE在治疗AR中有一定的积极作用，但我们没有发现肉桂皮提取物对变应性鼻炎有效的证据。需要使用CE进行良好的随机临床试验，以进一步提高我们对AR有效性的理解。
{"title":"EFFECTIVENESS OF CINNAMON BARK EXTRACT IN THE TREATMENT OF ALLERGIC RHINITIS","authors":"Giovana Scachetti, O. Person, Beatriz Gregio Soares, Rafael Porpino, P. Bogar, Fernando Veiga Angélico Júnior","doi":"10.56242/globalhealth;2020;1;1;57-60","DOIUrl":"https://doi.org/10.56242/globalhealth;2020;1;1;57-60","url":null,"abstract":"OBJECTIVE: The purpose is to evaluate the effectiveness and safety of intranasal cinnamon extract (CE) in the management of patients with allergic rhinitis (AR). METHODS: This is a systematic review, using the standard methodological procedures recommended by Cochrane to search six databases: Cochrane, PUBMED, EMBASE and LILACS, from database inception up to May 2020, to identify randomized controlled trials evaluating the use of CE in treatment for AR. RESULTS: We included two trials involving a total of 100 participants. The studies were at low risk of bias. All studies had similar participant selection criteria and outcome measurement, enabling a meta-analysis. Both studies used a validated instrument (Rhinoconjunctivitis quality of life questionnaire – RQLQ) for this primary outcome (SMD -1.06; 95% confidence interval (CI) -1.58 to -0.59, P <0.0001). . All studies resulted in at least some clinical benefit with the use of CE compared to placebo. None of the included studies reported any significant adverse effects. CONCLUSION: Despite the evidence from two studies showed certain positive effects of response for CE under evaluation in treatment of AR. We found no evidence regarding the effectiveness of cinnamon bark extract for allergic rhinitis. Well-conducted randomized clinical trials using CE are needed to further advance our understanding of the effectiveness of AR.","PeriodicalId":285800,"journal":{"name":"Brazilian Journal of Global Health","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126842253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-27DOI: 10.56242/globalhealth;2020;1;1;42-46
Renato Jimenez Gomez, Gabriela Ferreira da Silva Ramos, Luiz Henrique Luiz Henrique Nali, H. Nascimento
OBJECTIVE: Nosocomial infections are considered a public health issue. Such infections can originate from a range of microorganisms and many of these microorganisms can be resistant to antibiotics. The use of cellular devices can contribute considerably to the transmission and maintenance of these microorganisms in hospital environments, which represents an additional risk to hospitalized patients and to the health professionals. Thus, the aim of this study was to carry out an integrative review to observe the frequency of contamination from cell phones, as well as the frequency of the main agents found. METHODS: For that, a validated instrument from URSI was used to analyze the main articles used in the study, the articles were collected from the VHL, PubMed, LILACS, BDENF and Medline databases. After applying the inclusion and exclusion criteria, we used 16 articles. RESULTS: A high frequency of the presence of bacteria, fungi and viruses has been identified. Among the most frequently found agents were Staphylococcus sp., Streptococcus sp., Bacilus sp., Acinetobacter sp., Klebsiella sp., Candida sp. Norovirus, among others. CONCLUSION: Most of the health professionals' cell phones were positive for at least one of these microorganisms, such frequent findings highlight the need to establish control measures and protocols in order to reduce the risk of nosocomial infection.
{"title":"THE USE OF CELL PHONES AS A POTENTIAL TRANSMISSION ROUTE OF MICROORGANISMS BY HEALTH PROFESSIONALS IN HOSPITALS: AN INTEGRATIVE REVIEW","authors":"Renato Jimenez Gomez, Gabriela Ferreira da Silva Ramos, Luiz Henrique Luiz Henrique Nali, H. Nascimento","doi":"10.56242/globalhealth;2020;1;1;42-46","DOIUrl":"https://doi.org/10.56242/globalhealth;2020;1;1;42-46","url":null,"abstract":"OBJECTIVE: Nosocomial infections are considered a public health issue. Such infections can originate from a range of microorganisms and many of these microorganisms can be resistant to antibiotics. The use of cellular devices can contribute considerably to the transmission and maintenance of these microorganisms in hospital environments, which represents an additional risk to hospitalized patients and to the health professionals. Thus, the aim of this study was to carry out an integrative review to observe the frequency of contamination from cell phones, as well as the frequency of the main agents found. METHODS: For that, a validated instrument from URSI was used to analyze the main articles used in the study, the articles were collected from the VHL, PubMed, LILACS, BDENF and Medline databases. After applying the inclusion and exclusion criteria, we used 16 articles. RESULTS: A high frequency of the presence of bacteria, fungi and viruses has been identified. Among the most frequently found agents were Staphylococcus sp., Streptococcus sp., Bacilus sp., Acinetobacter sp., Klebsiella sp., Candida sp. Norovirus, among others. CONCLUSION: Most of the health professionals' cell phones were positive for at least one of these microorganisms, such frequent findings highlight the need to establish control measures and protocols in order to reduce the risk of nosocomial infection.","PeriodicalId":285800,"journal":{"name":"Brazilian Journal of Global Health","volume":"5 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114005264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-11-27DOI: 10.56242/globalhealth;2020;1;1;52-56
Lucas Guilherme Oliveira da Silva, Warlindo Carneiro da Silva Neto, Daniel Borges Pereira, A. Ribeiro
OBJECTIVE: Running is a sport activity that has been growing worldwide. However, most beginner runners are affected by injuries, with the foot type and plantar overload being the main risk factors for its appearance. The purpose of this study was to verify the effect of foot posture on the plantar load distribution of beginning runners. METHODS: 114 novice runners from sports clubs in the state of São Paulo, with a rearfoot running pattern, were evaluated. The type of foot posture was evaluated using the plantar arch index recorded by the podoscope. Thus, runners were divided into three groups: cavus feet (CF, n=47), normal feet (NF, n=34) and flat feet (FF, n=33). Plantar pressure distribution was assessed using the pressure platform (Loran®,Italy), considering the feet regions (forefoot, midfoot and medial and lateral rearfoot). The variables measured were: maximum force and peak pressure. Analysis of Variance, followed by Tukey's post-hoc was performed, considering differences p<0.05. RESULTS: Runners with cavus feet (high plantar arch) had higher peak pressure in the forefoot area and lateral rearfoot, such as maximum force on lateral rearfoot, in relation to groups with normal and flat feet, but decreased in the midfoot area. In the medial rearfoot, there were no differences observed between the groups. However, runners with flat feet reduced peak pressure over the forefoot and rearfoot areas (medial and lateral), but increased over the midfoot, when compared to cavus and normal feet. CONCLUSION: Beginner runners with cavus feet posture increase the plantar load over the forefoot and lateral reartfoot regions while flat feet increase over the midfoot. These findings help to understand the need for gait training to improve the plantar load distribution pattern.
{"title":"EFFECT OF FOOT POSTURE ON PLANTAR SUPPORT DURING GAIT OF ADULT BEGINNERS IN RUNNING","authors":"Lucas Guilherme Oliveira da Silva, Warlindo Carneiro da Silva Neto, Daniel Borges Pereira, A. Ribeiro","doi":"10.56242/globalhealth;2020;1;1;52-56","DOIUrl":"https://doi.org/10.56242/globalhealth;2020;1;1;52-56","url":null,"abstract":"OBJECTIVE: Running is a sport activity that has been growing worldwide. However, most beginner runners are affected by injuries, with the foot type and plantar overload being the main risk factors for its appearance. The purpose of this study was to verify the effect of foot posture on the plantar load distribution of beginning runners. METHODS: 114 novice runners from sports clubs in the state of São Paulo, with a rearfoot running pattern, were evaluated. The type of foot posture was evaluated using the plantar arch index recorded by the podoscope. Thus, runners were divided into three groups: cavus feet (CF, n=47), normal feet (NF, n=34) and flat feet (FF, n=33). Plantar pressure distribution was assessed using the pressure platform (Loran®,Italy), considering the feet regions (forefoot, midfoot and medial and lateral rearfoot). The variables measured were: maximum force and peak pressure. Analysis of Variance, followed by Tukey's post-hoc was performed, considering differences p<0.05. RESULTS: Runners with cavus feet (high plantar arch) had higher peak pressure in the forefoot area and lateral rearfoot, such as maximum force on lateral rearfoot, in relation to groups with normal and flat feet, but decreased in the midfoot area. In the medial rearfoot, there were no differences observed between the groups. However, runners with flat feet reduced peak pressure over the forefoot and rearfoot areas (medial and lateral), but increased over the midfoot, when compared to cavus and normal feet. CONCLUSION: Beginner runners with cavus feet posture increase the plantar load over the forefoot and lateral reartfoot regions while flat feet increase over the midfoot. These findings help to understand the need for gait training to improve the plantar load distribution pattern.","PeriodicalId":285800,"journal":{"name":"Brazilian Journal of Global Health","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133170599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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