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Convulsión febril 热性惊厥
Pub Date : 2023-11-22 DOI: 10.5354/2735-7996.2014.72806
Mario Matamala C., Miguel Guzmán N., Javiera Aguirre E.
Febrile seizures are the most common seizure disorder in the pediatric population and represent a frequent cause of consultation in emergency departments, confirming its importance. We present an updated and practical review regarding this pathology, along with an operative definition that supports the application of a flowchart that integrates concepts and procedures that can be easily applied at any location nationwide. This review is designed to provide an analytic framework regarding pediatric febrile seizures, as well as present a guideline based on our experience in the emergency department by summarizing the main benzodiazepines in actual use that have been proved to be both safe and effective in treating this disorder, such as lorazepam and midazolam
热性惊厥是儿科最常见的惊厥性疾病,也是急诊科的常见病因,其重要性不言而喻。我们对这一病理现象进行了最新的实用性综述,并给出了操作定义,支持应用流程图,该流程图整合了各种概念和程序,可在全国任何地方轻松应用。本综述旨在提供一个有关小儿发热性癫痫发作的分析框架,并根据我们在急诊科的经验提出一个指南,总结了实际使用中被证明在治疗这种疾病方面既安全又有效的主要苯二氮卓类药物,如劳拉西泮和米达唑仑。
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引用次数: 0
Nuevas estrategias farmacológicas en la enfermedad de Alzheimer: la hiperactividad y la neuroinflamación como nuevos blancos potenciales 阿尔茨海默病的新药理学策略:多动症和神经炎症作为潜在的新靶点
Pub Date : 2023-08-03 DOI: 10.5354/2735-7996.2023.71414
Pedro Lobos Z., Jamileth More C., Bárbara Bruna J., Antonello Penna S.
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the progressive deterioration of cognitive functions such as memory, language, executive function, and visuospatial function, starting from the late ages of life (> 65 years). The etiology of AD is multifactorial involving the interaction of genetic, environmental, and systemic factors. Histopathologically characterized by the progressive accumulation of peptide Aβ and TAU protein. Markers of damage that begin to accumulate decades before symptoms can be detected. However, during the early stages of the disease, systemic inflammation and cortical/hippocampal hyperactivity have been revealed present in patients. In the following review, we present a perspective on how neuroinflammatory processes and pathological cortical hyperexcitability contribute to the onset and development of the early stages of AD. We present a current summary of the basic and clinical evidence that allows us to understand the complexity and heterogeneity of this pathology. Finally, we briefly collect and analyze the main therapeutic strategies that have been studied to reduce the phenotype of neuronal hyperactivity directly or indirectly.
阿尔茨海默病(AD)是一种神经退行性疾病,其特征是认知功能(如记忆、语言、执行功能和视觉空间功能)从晚年(> 65岁)开始逐渐恶化。阿尔茨海默病的病因是多因素的,涉及遗传、环境和全身因素的相互作用。组织病理学特征为肽Aβ和TAU蛋白的进行性积累。损伤的标志在症状被发现之前就已经开始积累了几十年。然而,在疾病的早期阶段,全身性炎症和皮质/海马过度活跃已经在患者中被发现。在以下回顾中,我们提出了神经炎症过程和病理性皮层高兴奋性如何促进早期AD的发病和发展的观点。我们目前的基础和临床证据的总结,使我们能够了解这种病理的复杂性和异质性。最后,我们简要地收集和分析了已研究的直接或间接减少神经元多动表型的主要治疗策略。
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引用次数: 0
Un extraño caso de trombosis venosa 静脉血栓形成的罕见病例
Pub Date : 2023-08-03 DOI: 10.5354/2735-7996.2023.71406
María Gabriela Caballero Q., Guillermo Conte L.
Ovarian vein thrombosis is a rare condition that is usually due to prothrombotic states. The clinical presentation is nonspecific, commonly with abdominal pain. Anticoagulation is fundamental to prevent complications and reduce morbidity and mortality. Enoxaparin and warfarin have traditionally been the anticoagulants of choice. Direct-acting anticoagulants are an alternative under study. This publication presents a case of a 60-year-old patient without predisposing factors for ovarian thrombosis, with low back pain, where the diagnosis was only achieved with Computed Tomography. Anticoagulation with rivaroxaban was started for a period of 3 months, obtaining resolution of symptoms and thrombosis.
卵巢静脉血栓形成是一种罕见的情况,通常是由于血栓前状态。临床表现无特异性,常伴有腹痛。抗凝是预防并发症和降低发病率和死亡率的基础。依诺肝素和华法林历来是抗凝血剂的首选。直接作用抗凝剂是一种正在研究中的替代方法。本出版物提出了一个病例60岁的患者没有卵巢血栓形成的易感因素,腰痛,其中诊断仅实现了计算机断层扫描。开始使用利伐沙班抗凝治疗3个月,症状和血栓消退。
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引用次数: 0
Reconstrucción nasal secundaria con injerto costal: caso clínico y revisión de la literatura 肋移植继发性鼻重建:临床病例及文献综述
Pub Date : 2023-08-03 DOI: 10.5354/2735-7996.2023.71407
T. González A., Sally Costa C., Nicolás Espinoza C., C. Erazo C.
Introduction: Secondary rhinoplasty, or reintervention, is a surgery on a previously operated nose, which represents a greater surgical challenge compared to primary rhinoplasty. The ideal is the use of autologous cartilage graft since it meets biocompatibility characteristics and resembles an ideal graft. The costal cartilage is a good alternative since it has characteristics similar to septal cartilage, with the advantage of offering a larger amount of material to work with and it does not deform over time. Clinical case: male, 31 years old, admitted due to a hit to the face with a blunt object. It evidenced complex facial fracture, with Le Fort I components on the right and Le Fort III components on the left, as well as a left naso-orbital-ethmoid fracture. It performs reduction and intermaxillary fixation. It performs nasal reconstruction with a double nasal cartilage graft and bone graft for the back, and septal cartilage graft to construct the columella stem. It plans secondary rhinoplasty with a seventh rib graft correct the saddle nose defect. Outpatient follow-up at 14 and 30 days with favorable cosmetic results. Discussion: This procedure generally gives good results with a low complication rate. In the latest systematic reviews with an average follow-up of 14.4 months (6-96 months) they concluded that in the donor area the most frequent complication was the development of scars in the surgical site with 2.08% (0. 31-4.83%) and pneumothorax was close to 0% (0-0.46%). In the recipient area, the most frequent were graft retraction with 3.05% (1.35-5.19%) and 1.45% (0.34-3.06%) of infection of the recipient area. Conclusion: With the presentation of this clinical case, you can observed that the use of costal cartilage in secondary rhinoplasty is an achievable option, with good results in the short and medium term, in addition to having a low rate of complications, but a team of experienced plastic surgery must perform it. Fecha recepción: noviembre 2022 | Fecha aceptación: febrero
简介:二次鼻成形术,或称再介入手术,是对以前手术过的鼻子进行的手术,与初次鼻成形术相比,它代表了更大的手术挑战。理想的是使用自体软骨移植,因为它符合生物相容性特征,类似于理想的移植物。肋软骨是一个很好的选择,因为它具有与间隔软骨相似的特征,具有提供大量材料的优势,并且不会随着时间的推移而变形。临床病例:男性,31岁,因脸部被钝器击中而入院。其表现为复杂的面部骨折,右侧为Le Fort I型骨折,左侧为Le Fort III型骨折,以及左侧鼻眶筛骨折。它用于复位和上颌间固定。采用双鼻软骨移植和背部骨移植,鼻中隔软骨移植重建鼻小柱干。它计划用第七根肋骨进行二次鼻整形,以纠正鞍鼻缺陷。门诊随访14天和30天,美容效果良好。讨论:该手术通常效果良好,并发症发生率低。在最新的系统回顾中,平均随访14.4个月(6-96个月),他们得出结论,在供体区,最常见的并发症是手术部位瘢痕的形成,占2.08%(0.08%)。31-4.83%),气胸接近0%(0-0.46%)。受区感染以移植物牵伸最多,分别占3.05%(1.35 ~ 5.19%)和1.45%(0.34 ~ 3.06%)。结论:通过本临床病例的介绍,可以看出肋软骨二期鼻成形术是一种可实现的选择,中短期效果良好,并发症发生率低,但必须由经验丰富的整形外科医生进行。Fecha recepción: noviem2022 | Fecha aceptación: febrero
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引用次数: 0
Investigación, innovación y desarrollo tecnológico en el Hospital Clínico Universidad de Chile 智利大学临床医院的研究、创新和技术发展
Pub Date : 2023-08-03 DOI: 10.5354/2735-7996.2023.71243
P. Délano R.
No abstract available
没有摘要
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引用次数: 0
Abstracts Jornadas de Calidad 2017 2017年质量会议摘要
Pub Date : 2023-05-12 DOI: 10.5354/2735-7996.2017.70647
Revista Hospital Clínico Universidad de Chile
Desde hace unos años, el Hospital Clínico Universidad de Chile a través de su Dirección de Calidad ha esta- blecido un espacio de desarrollo y enriquecimiento institucional de sus prácticas y está enfocado en contribuir a la formación de una cultura de calidad y seguridad de los pacientes que permita posicionar y alinear la calidad en todos los niveles del quehacer de su Institución. Es por esto que desde hace unos años organiza las Jornadas de Calidad HCUCH en las cuales se presentan trabajos realizados localmente que tuvieron como objetivo la obtención de mejores resultados en la atención de los pacientes. A continuación compartimos los trabajos presentados en su versión 2017.
从几年前,医院临床智利大学通过其质量上领导这个- blecido体制发展空间和充实其做法,并且集中在帮助培训质量和患者安全文化定位并使各级质量日常工作的机构。这就是为什么几年来,它组织了HCUCH质量日,在那里展示了在当地进行的工作,目的是在病人护理中获得更好的结果。下面我们分享2017年版本的作品。
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引用次数: 0
Serie guías clínicas: manejo de la hipertensión crónica en el embarazo 临床指南系列:妊娠期慢性高血压的管理
Pub Date : 2023-05-09 DOI: 10.5354/2735-7996.2017.70606
Álvaro Sepúlveda-Martínez, E. Segovia R, Mauro Parra-Cordero
1. Conocer la morbilidad materna asociada a la hipertensión durante el embarazo. 2. Conocer la morbilidad fetal y perinatal asociada a la hipertensión durante el embarazo. 3. Aplicar las estrategias de prevención de preeclampsia en pacientes hipertensas. 4. Conocer la terapia farmacológica validada para el manejo de la hipertensión durante el embarazo. 5. Determinar cifras tensionales para inicio de terapia farmacológica antihipertensiva oral. 6. Determinar cifras tensionales para inicio de terapia antihipertensiva endovenosa. 7. Aplicar metas tensionales para el manejo farmacológico antihipertensivo. 8. Establecer la edad gestacional de interrupción de pacientes portadoras de hipertensión arterial crónica. 9. Aplicar terapias antihipertensivas recomendadas durante la lactancia.
1. 了解怀孕期间与高血压相关的母亲发病率。2. 了解妊娠期间与高血压相关的胎儿和围产期发病率。3. 高血压患者子痫前期预防策略的应用。4. 了解怀孕期间高血压管理的有效药物治疗。5. 确定开始口服降压药物治疗的血压数字。6. 确定开始静脉降压治疗的血压数字。7. 在抗高血压药物管理中应用紧张目标。8. 确定慢性高血压患者终止妊娠的年龄。9. 在哺乳期间应用推荐的降压疗法。
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引用次数: 0
Calprotectina fecal: utilidad en el diagnóstico diferencial de enfermedad inflamatoria intestinal y síndrome intestino irritable en adultos 粪便钙保护素:用于鉴别诊断成人炎症性肠病和肠易激综合征
Pub Date : 2023-04-18 DOI: 10.5354/2735-7996.2018.70354
Natalia Covarrubias R., A. Madrid S., René Rojas B., M. Gompertz G.
Differentiation between inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) can be complex as their symptoms are often similar and unspecific. Fecal biomarkers could be useful to select patients with suspected organic diseases for colonoscopy, with the aim to improve early diagnosis and to avoid unnecessary invasive studies. Fecal calprotectin (FC) is a protein found mainly in neutrophils that is released into the feces as a result of cell disruption and apoptosis. Currently, FC is a simple and non-invasive biomarker of intestinal inflammation. Inflammatory gastrointestinal disorders are associated with high levels of FC, as occurs in IBD. This review focuses on FC as a useful tool for differential diagnosis between IBS and IBD in adults.
炎症性肠病(IBD)和肠易激综合征(IBS)的区分可能很复杂,因为它们的症状通常相似且不特异性。粪便生物标志物可用于选择疑似器质性疾病的患者进行结肠镜检查,目的是改善早期诊断并避免不必要的侵入性检查。粪钙保护蛋白(FC)是一种主要存在于中性粒细胞中的蛋白质,由于细胞破坏和凋亡而释放到粪便中。目前,FC是一种简单且无创的肠道炎症生物标志物。炎症性胃肠道疾病与高水平的FC相关,如IBD。这篇综述的重点是FC作为成人IBS和IBD鉴别诊断的有用工具。
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引用次数: 0
Abstracts Jornadas Calidad 2018 2018年质量会议摘要
Pub Date : 2023-04-18 DOI: 10.5354/2735-7996.2018.70356
Revista Hospital Clínico Universidad de Chile
Desde hace unos añ os, el Hospital Clínico Universidad de Chile a través de su Dirección de Calidad ha esta- blecido un espacio de desarrollo y enriquecimiento institucional de sus prácticas, enfocado en contribuir a la formación de una cultura de calidad y seguridad de los pacientes que permita alinear éstas en todos los niveles del quehacer de su Institución. Es por esto que se ha establecido como una de las estrategias de difusión, ampliación y profundización de los temas de seguridad y calidad institucional, la realización de las Jornadas de Calidad HCUCH. En ellas se presentan trabajos que corresponden a iniciativas locales que tuvieron como objetivo la obtención de mejores resultados en la atención de los pacientes. A continuación compartimos una selección de los trabajos presenta- dos en su versión 2018.
好几años,医院临床质量智利大学通过其地址这个- blecido发展空间和浓缩了体制的做法,重点放在有助于形成文化质量和患者安全问题能够使这些工作的各级机构。这就是为什么HCUCH质量会议被确立为传播、扩大和深化安全和机构质量问题的战略之一。在本研究中,我们提出了一些与地方倡议相对应的工作,这些倡议旨在在病人护理方面取得更好的结果。下面我们分享一些2018年版本的作品。
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引用次数: 0
Resúmenes IV Jornadas de Investigación 2022: "Salud e ingeniería: soluciones innovadoras en HCUCH" 四、2022年研究会议摘要:“健康与工程:HCUCH的创新解决方案”
Pub Date : 2023-04-18 DOI: 10.5354/2735-7996.2023.70355
Revista Hospital Clínico Universidad de Chile
No abstract available
没有摘要
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引用次数: 0
期刊
Revista Hospital Clínico Universidad de Chile
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