首页 > 最新文献

Journal of Diabetes and Endocrine Practice最新文献

英文 中文
Safely Withdrawing Glucocorticoid Therapy: A Case-Based Approach 安全撤出糖皮质激素治疗:基于病例的方法
Pub Date : 2024-07-04 DOI: 10.1055/s-0044-1788035
Mohammed Alenazi, Khaled A Aldahmani, S. Imran
Abstract Glucocorticoids (GCs) have potent anti-inflammatory and immunomodulating effects, making them effective for treating various diseases. They are among the most commonly prescribed medications worldwide. The prevalence of GC therapy in the general population is estimated to be ∼0.9 to 3%, though it is challenging to determine precisely. The chronic GC therapy is associated with severe morbidity and increased mortality due to iatrogenic Cushing's syndrome and suppression of the hypothalamic–pituitary–adrenal axis, leading to tertiary adrenal insufficiency. Therefore, it is not recommended to abruptly stop chronic GC therapy, and a gradual tapering of GCs is generally considered the ideal approach for GCs withdrawal. However, withdrawing GCs in patients on chronic therapy can be challenging due to the difficulty in accurately assessing HPA function. In this article, we aim to provide a practical, case-based approach to GC withdrawal based on current literature and our extensive experience in this field.
摘要 糖皮质激素(GCs)具有强大的抗炎和免疫调节作用,可有效治疗各种疾病。它们是全球最常用的处方药之一。据估计,GC 类药物在普通人群中的使用率约为 0.9% 至 3%,但要准确确定这一比例却很困难。慢性丙种球蛋白治疗与严重的发病率和死亡率增加有关,其原因是先天性库欣综合征和下丘脑-垂体-肾上腺轴抑制,导致三级肾上腺功能不全。因此,不建议突然停止慢性 GCs 治疗,一般认为逐步减少 GCs 是理想的 GCs 停药方法。然而,由于难以准确评估 HPA 功能,长期接受治疗的患者停用 GCs 可能具有挑战性。在本文中,我们将根据目前的文献和我们在这一领域的丰富经验,提供一种实用的、基于病例的 GCs 停药方法。
{"title":"Safely Withdrawing Glucocorticoid Therapy: A Case-Based Approach","authors":"Mohammed Alenazi, Khaled A Aldahmani, S. Imran","doi":"10.1055/s-0044-1788035","DOIUrl":"https://doi.org/10.1055/s-0044-1788035","url":null,"abstract":"Abstract Glucocorticoids (GCs) have potent anti-inflammatory and immunomodulating effects, making them effective for treating various diseases. They are among the most commonly prescribed medications worldwide. The prevalence of GC therapy in the general population is estimated to be ∼0.9 to 3%, though it is challenging to determine precisely. The chronic GC therapy is associated with severe morbidity and increased mortality due to iatrogenic Cushing's syndrome and suppression of the hypothalamic–pituitary–adrenal axis, leading to tertiary adrenal insufficiency. Therefore, it is not recommended to abruptly stop chronic GC therapy, and a gradual tapering of GCs is generally considered the ideal approach for GCs withdrawal. However, withdrawing GCs in patients on chronic therapy can be challenging due to the difficulty in accurately assessing HPA function. In this article, we aim to provide a practical, case-based approach to GC withdrawal based on current literature and our extensive experience in this field.","PeriodicalId":294186,"journal":{"name":"Journal of Diabetes and Endocrine Practice","volume":" 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Review of the Diagnostic and Prognostic Values of Cardiac Markers in Diabetes 糖尿病患者心脏标志物的诊断和预后价值综述
Pub Date : 2024-05-13 DOI: 10.1055/s-0044-1786014
Tabarak Haamid Elbo-Iswadi, H. Alsharayri, Rahaf Wardeh, A. Bashier, Fauzia Rashid, Elamin Ibrahim Abdelgadir
Introduction Cardiovascular disease is a leading cause of mortality in people with diabetes (PWD). We aimed to explore the role of troponin T (TnT) and probrain natriuretic peptide (proBNP) as screening and prognostic indicators of cardiovascular morbidity and mortality in PWD in the existing literature. Methods This review paper is a focused narrative nonsystematic review of the literature which examined relevant publications pertinent to the significance of cardiac biomarkers. We aimed to investigate the diagnostic value of cardiac TnT (cTnT) and cTnI in addition to proBNP in diabetes and the prognostic value of cTnT and proBNP in diabetic and nondiabetic patients. The process of searching through literature was conducted from December 2022 to April 2023. Searches were done across PubMed and Google Scholar databases to identify relevant articles published from January 2001 to April 2023. The selected were entered into EndNote 20 software to extract the title and abstract. Results A total of 75 articles were identified in Google Scholar in addition to 32 articles from PubMed. After a thorough review, only a total of 22 articles were selected, pointing out those which discussed the pathophysiology and diagnostic, prognostic, and screening values of the types of Tn and proBNP markers. The value of TnT in PWD, specifically T2D, is threefold higher than in healthy patients. Individuals with high levels of high-sensitivity (hs) cTnI or cTnT were at the highest mortality risk. Nonetheless, N-terminal (NT)-proBNP and TnT function independently as predictors of unfavorable outcomes. Conclusions TnT is an important early screening tool prognostic indicator. Elevated TnT was associated with an increased risk of cardiovascular events in PWD. hs-cTn may help diabetes-related clinical care for older persons by identifying those at high mortality risk; furthermore, in diabetic individuals, NT-pro-BNP appears to be 92% sensitive and 90% specific for the diagnosis of heart failure.
导言心血管疾病是糖尿病患者(PWD)死亡的主要原因。我们旨在探讨现有文献中肌钙蛋白 T (TnT) 和血清钠尿肽 (proBNP) 作为糖尿病患者心血管疾病发病率和死亡率的筛查和预后指标的作用。方法 本文是一篇非系统性的重点文献综述,研究了与心脏生物标志物的意义相关的出版物。我们的目的是研究除 proBNP 外,心脏 TnT(cTnT)和 cTnI 对糖尿病的诊断价值,以及 cTnT 和 proBNP 对糖尿病患者和非糖尿病患者的预后价值。文献检索时间为 2022 年 12 月至 2023 年 4 月。在 PubMed 和 Google Scholar 数据库中进行检索,以确定 2001 年 1 月至 2023 年 4 月期间发表的相关文章。将所选文章输入 EndNote 20 软件,提取标题和摘要。结果 在谷歌学术上共找到 75 篇文章,此外还从 PubMed 上找到 32 篇文章。经过全面审查后,只选取了 22 篇文章,指出其中讨论了 Tn 和 proBNP 标记类型的病理生理学、诊断、预后和筛查价值。TnT 在残疾人(尤其是 T2D 患者)中的价值是健康患者的三倍。高灵敏度(hs)cTnI 或 cTnT 水平较高的人死亡风险最高。尽管如此,N-末端(NT)-proBNP 和 TnT 仍可独立预测不良预后。结论 TnT 是一个重要的早期筛查工具预后指标。hs-cTn 可通过识别高死亡风险人群来帮助老年人进行糖尿病相关的临床治疗;此外,在糖尿病患者中,NT-pro-BNP 对心衰诊断的敏感性和特异性分别为 92% 和 90%。
{"title":"Review of the Diagnostic and Prognostic Values of Cardiac Markers in Diabetes","authors":"Tabarak Haamid Elbo-Iswadi, H. Alsharayri, Rahaf Wardeh, A. Bashier, Fauzia Rashid, Elamin Ibrahim Abdelgadir","doi":"10.1055/s-0044-1786014","DOIUrl":"https://doi.org/10.1055/s-0044-1786014","url":null,"abstract":"\u0000 Introduction Cardiovascular disease is a leading cause of mortality in people with diabetes (PWD). We aimed to explore the role of troponin T (TnT) and probrain natriuretic peptide (proBNP) as screening and prognostic indicators of cardiovascular morbidity and mortality in PWD in the existing literature.\u0000 Methods This review paper is a focused narrative nonsystematic review of the literature which examined relevant publications pertinent to the significance of cardiac biomarkers. We aimed to investigate the diagnostic value of cardiac TnT (cTnT) and cTnI in addition to proBNP in diabetes and the prognostic value of cTnT and proBNP in diabetic and nondiabetic patients. The process of searching through literature was conducted from December 2022 to April 2023. Searches were done across PubMed and Google Scholar databases to identify relevant articles published from January 2001 to April 2023. The selected were entered into EndNote 20 software to extract the title and abstract.\u0000 Results A total of 75 articles were identified in Google Scholar in addition to 32 articles from PubMed. After a thorough review, only a total of 22 articles were selected, pointing out those which discussed the pathophysiology and diagnostic, prognostic, and screening values of the types of Tn and proBNP markers. The value of TnT in PWD, specifically T2D, is threefold higher than in healthy patients. Individuals with high levels of high-sensitivity (hs) cTnI or cTnT were at the highest mortality risk. Nonetheless, N-terminal (NT)-proBNP and TnT function independently as predictors of unfavorable outcomes.\u0000 Conclusions TnT is an important early screening tool prognostic indicator. Elevated TnT was associated with an increased risk of cardiovascular events in PWD. hs-cTn may help diabetes-related clinical care for older persons by identifying those at high mortality risk; furthermore, in diabetic individuals, NT-pro-BNP appears to be 92% sensitive and 90% specific for the diagnosis of heart failure.","PeriodicalId":294186,"journal":{"name":"Journal of Diabetes and Endocrine Practice","volume":"76 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140984749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabetes, Kidneys, Heart, and Ramadan 糖尿病、肾脏、心脏和斋月
Pub Date : 2024-05-01 DOI: 10.1055/s-0044-1786190
S. Beshyah
{"title":"Diabetes, Kidneys, Heart, and Ramadan","authors":"S. Beshyah","doi":"10.1055/s-0044-1786190","DOIUrl":"https://doi.org/10.1055/s-0044-1786190","url":null,"abstract":"","PeriodicalId":294186,"journal":{"name":"Journal of Diabetes and Endocrine Practice","volume":"2012 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141027352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Fifth United Arab Emirates Obesity Conference, November 4–5, 2023, Abu Dhabi, UAE 第五届阿拉伯联合酋长国肥胖症大会,2023 年 11 月 4-5 日,阿联酋阿布扎比
Pub Date : 2023-10-01 DOI: 10.1055/s-0043-1777357
L. N. R. Bondugulapati, Rita Nawar, Hussam Abusahmin, Rahat Ghazanfar, S. Beshyah
Abstract The Fifth United Arab Emirates Obesity Conference was held from November 4 to 5, 2023, in Dusit Thani, Abu Dhabi, UAE. The theme of the conference was “What can we do better in obesity management?” The program included several didactic lectures and a question-and-answer time separately or grouped thematically. Over 2 days, the speakers covered the burden, definitions, and evaluation of obesity, including uncommon chromosomal and genetic syndromes associated with obesity in appropriate cases. It highlighted the importance of policy changes for public health improvement and prevention of obesity, the role of multidisciplinary teams in managing persons with obesity holistically, and present and future therapies, including personalized precision medicine backed up by science.
摘要 第五届阿拉伯联合酋长国肥胖症大会于 2023 年 11 月 4 日至 5 日在阿联酋阿布扎比的 Dusit Thani 举行。会议的主题是 "在肥胖症管理方面,我们能做得更好吗?会议日程包括多场专题讲座和问答时间,分别或按主题分组进行。在两天的时间里,演讲者讲述了肥胖症的负担、定义和评估,包括在适当情况下与肥胖症相关的不常见染色体和遗传综合征。会议强调了改善公共卫生和预防肥胖症的政策变化的重要性、多学科团队在全面管理肥胖症患者方面的作用,以及当前和未来的疗法,包括有科学依据的个性化精准医疗。
{"title":"The Fifth United Arab Emirates Obesity Conference, November 4–5, 2023, Abu Dhabi, UAE","authors":"L. N. R. Bondugulapati, Rita Nawar, Hussam Abusahmin, Rahat Ghazanfar, S. Beshyah","doi":"10.1055/s-0043-1777357","DOIUrl":"https://doi.org/10.1055/s-0043-1777357","url":null,"abstract":"Abstract The Fifth United Arab Emirates Obesity Conference was held from November 4 to 5, 2023, in Dusit Thani, Abu Dhabi, UAE. The theme of the conference was “What can we do better in obesity management?” The program included several didactic lectures and a question-and-answer time separately or grouped thematically. Over 2 days, the speakers covered the burden, definitions, and evaluation of obesity, including uncommon chromosomal and genetic syndromes associated with obesity in appropriate cases. It highlighted the importance of policy changes for public health improvement and prevention of obesity, the role of multidisciplinary teams in managing persons with obesity holistically, and present and future therapies, including personalized precision medicine backed up by science.","PeriodicalId":294186,"journal":{"name":"Journal of Diabetes and Endocrine Practice","volume":"17 1","pages":"149 - 152"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139325496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Journal of Diabetes and Endocrine Practice (2018–2023): A Quest for a Role! 糖尿病与内分泌实践杂志(2018-2023)》:角色的探索!
Pub Date : 2023-10-01 DOI: 10.1055/s-0043-1777358
S. Beshyah
{"title":"Journal of Diabetes and Endocrine Practice (2018–2023): A Quest for a Role!","authors":"S. Beshyah","doi":"10.1055/s-0043-1777358","DOIUrl":"https://doi.org/10.1055/s-0043-1777358","url":null,"abstract":"","PeriodicalId":294186,"journal":{"name":"Journal of Diabetes and Endocrine Practice","volume":"62 1","pages":"147 - 148"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139327798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Free Communications of the Gulf Association of Endocrinology and Diabetes Annual Congress 2023, Muscat, Oman, October 19–21, 2023 海湾内分泌学和糖尿病协会 2023 年年会免费通讯,阿曼马斯喀特,2023 年 10 月 19-21 日
Pub Date : 2023-10-01 DOI: 10.1055/s-0043-1777328
T. Alessa, W. Hussein, B. Afandi, Ali Al Reesi, Naji Aljohani
These are the abstracts of the Clinical Congress of the Gulf Association of Endocrinology and Diabetes (GAED) held on October 19 – 21, 2023. 1,2 The educational objective of the congress was to give a “ state of the art in endocrine practice. ” The programs included plenary symposia, delivered by international and regional keyopinion leaders. In addition, free communications on current research and clinical practice within and beyond the Gulf region were presented as oral presentations and posters. We present here the abstracts of these free communications after minimal restyling and editing to suit the publication requirements of the journal. We hope that by publishing them in our open-access journal, we provide early recognition of the work and extend the bene fi t to those who could not make it to the live presentations similar to our previous conferences. 3 – 6 We also hope to stimulate networking between parties of mutual research interests.
本文是 2023 年 10 月 19-21 日召开的海湾内分泌学和糖尿病协会(GAED)临床大会的摘要。1,2 大会的教育目标是介绍 "内分泌实践的最新进展"。"大会日程包括全体专题讨论会,由国际和地区的主要意见领袖主讲。此外,大会还以口头报告和海报的形式就海湾地区内外的当前研究和临床实践进行了自由交流。为了适应期刊的出版要求,我们对这些自由交流的摘要进行了最小程度的重新编排和编辑,在此予以刊载。我们希望,通过在我们的开放式期刊上发表这些摘要,能让这些工作尽早得到认可,并让那些无法参加类似以往会议的现场演讲的人也能从中受益。3 - 6 我们还希望促进共同研究兴趣者之间的联系。
{"title":"Free Communications of the Gulf Association of Endocrinology and Diabetes Annual Congress 2023, Muscat, Oman, October 19–21, 2023","authors":"T. Alessa, W. Hussein, B. Afandi, Ali Al Reesi, Naji Aljohani","doi":"10.1055/s-0043-1777328","DOIUrl":"https://doi.org/10.1055/s-0043-1777328","url":null,"abstract":"These are the abstracts of the Clinical Congress of the Gulf Association of Endocrinology and Diabetes (GAED) held on October 19 – 21, 2023. 1,2 The educational objective of the congress was to give a “ state of the art in endocrine practice. ” The programs included plenary symposia, delivered by international and regional keyopinion leaders. In addition, free communications on current research and clinical practice within and beyond the Gulf region were presented as oral presentations and posters. We present here the abstracts of these free communications after minimal restyling and editing to suit the publication requirements of the journal. We hope that by publishing them in our open-access journal, we provide early recognition of the work and extend the bene fi t to those who could not make it to the live presentations similar to our previous conferences. 3 – 6 We also hope to stimulate networking between parties of mutual research interests.","PeriodicalId":294186,"journal":{"name":"Journal of Diabetes and Endocrine Practice","volume":"74 4 1","pages":"155 - 197"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139329099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Gulf Association of Endocrinology and Diabetes in 2023: A Message from the President and Officers 2023 年的海湾内分泌学与糖尿病协会:主席和官员致辞
Pub Date : 2023-10-01 DOI: 10.1055/s-0043-1777268
Ali Al Mamari, Naji Aljohani, Tarik AlHadd
{"title":"The Gulf Association of Endocrinology and Diabetes in 2023: A Message from the President and Officers","authors":"Ali Al Mamari, Naji Aljohani, Tarik AlHadd","doi":"10.1055/s-0043-1777268","DOIUrl":"https://doi.org/10.1055/s-0043-1777268","url":null,"abstract":"","PeriodicalId":294186,"journal":{"name":"Journal of Diabetes and Endocrine Practice","volume":"255 1","pages":"153 - 154"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139326059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Insulin Analogs and Human Insulins: A Narrative Review 胰岛素类似物与人胰岛素的比较综述
Pub Date : 2023-08-10 DOI: 10.1055/s-0043-1771027
M. Eledrisi, M. Danjuma
Abstract Introduction  Since insulin analogs have pharmacological properties that are similar to the normal physiological action of insulin, it has been suggested that they provide better glucose control and less rates of hypoglycemia compared to human insulins. Methods  We performed a narrative, nonsystematic review of the literature including clinical trials, systematic reviews, meta-analyses, and professional guidelines related to the comparison of human insulins and insulin analogs in terms of glucose control, safety profile, and cost. Results  Long-acting basal insulins result in mild improvement in glucose control and less rates of nocturnal hypoglycemic compared to neutral protamine Hagedorn insulin, mainly among patients with type 1 diabetes. Rapid-acting insulin analogs provide better glucose control and lower rates of hypoglycemia compared to regular insulin among patients with type 1 diabetes, whereas no advantage has been shown for insulin analogs among patients with type 2 diabetes for glucose control or hypoglycemia. Premixed insulin analogs provided no advantage in glucose control and inconsistent benefit in lowering the rates of hypoglycemia compared to human premixed insulins among patients with type 2 diabetes. The cost of insulin analogs is significantly higher than human insulins, and favorable cost-effectiveness has only been demonstrated for rapid-acting insulin analogs in type 1 diabetes. Conclusion  Currently available evidence supports the use of rapid-acting insulin analogs and possibly long-acting basal insulin over human insulins for patients with type 1 diabetes. For patients with type 2 diabetes, the use of long-acting insulin analogs may be recommended for selected patients who are at an increased risk of significant hypoglycemia, while no clear benefits of meal insulin analogs over human insulins have been observed.
由于胰岛素类似物具有类似于胰岛素正常生理作用的药理特性,因此有研究表明,与人用胰岛素相比,胰岛素类似物具有更好的血糖控制和更低的低血糖率。方法:我们对文献进行叙述性、非系统回顾,包括临床试验、系统回顾、荟萃分析和专业指南,这些文献与人胰岛素和胰岛素类似物在血糖控制、安全性和成本方面的比较有关。结果与中性鱼精蛋白Hagedorn胰岛素相比,长效基础胰岛素可轻度改善血糖控制,降低夜间低血糖发生率,主要发生在1型糖尿病患者中。与常规胰岛素相比,速效胰岛素类似物在1型糖尿病患者中提供更好的血糖控制和更低的低血糖率,而胰岛素类似物在2型糖尿病患者中没有显示出血糖控制或低血糖的优势。在2型糖尿病患者中,与人预混合胰岛素相比,预混合胰岛素类似物在血糖控制方面没有优势,在降低低血糖率方面的益处也不一致。胰岛素类似物的成本明显高于人用胰岛素,只有在治疗1型糖尿病的速效胰岛素类似物中才显示出良好的成本效益。结论:现有证据支持在1型糖尿病患者中使用速效胰岛素类似物和可能的长效基础胰岛素而不是人胰岛素。对于2型糖尿病患者,对于有明显低血糖风险增加的患者,可以推荐使用长效胰岛素类似物,但没有观察到膳食胰岛素类似物优于人用胰岛素的明显益处。
{"title":"Comparison of Insulin Analogs and Human Insulins: A Narrative Review","authors":"M. Eledrisi, M. Danjuma","doi":"10.1055/s-0043-1771027","DOIUrl":"https://doi.org/10.1055/s-0043-1771027","url":null,"abstract":"Abstract Introduction  Since insulin analogs have pharmacological properties that are similar to the normal physiological action of insulin, it has been suggested that they provide better glucose control and less rates of hypoglycemia compared to human insulins. Methods  We performed a narrative, nonsystematic review of the literature including clinical trials, systematic reviews, meta-analyses, and professional guidelines related to the comparison of human insulins and insulin analogs in terms of glucose control, safety profile, and cost. Results  Long-acting basal insulins result in mild improvement in glucose control and less rates of nocturnal hypoglycemic compared to neutral protamine Hagedorn insulin, mainly among patients with type 1 diabetes. Rapid-acting insulin analogs provide better glucose control and lower rates of hypoglycemia compared to regular insulin among patients with type 1 diabetes, whereas no advantage has been shown for insulin analogs among patients with type 2 diabetes for glucose control or hypoglycemia. Premixed insulin analogs provided no advantage in glucose control and inconsistent benefit in lowering the rates of hypoglycemia compared to human premixed insulins among patients with type 2 diabetes. The cost of insulin analogs is significantly higher than human insulins, and favorable cost-effectiveness has only been demonstrated for rapid-acting insulin analogs in type 1 diabetes. Conclusion  Currently available evidence supports the use of rapid-acting insulin analogs and possibly long-acting basal insulin over human insulins for patients with type 1 diabetes. For patients with type 2 diabetes, the use of long-acting insulin analogs may be recommended for selected patients who are at an increased risk of significant hypoglycemia, while no clear benefits of meal insulin analogs over human insulins have been observed.","PeriodicalId":294186,"journal":{"name":"Journal of Diabetes and Endocrine Practice","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128449192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ramadan Fasting and Diabetes (2022): The Year in Review 斋月禁食与糖尿病(2022年):回顾一年
Pub Date : 2023-04-03 DOI: 10.1055/s-0043-1764458
Khadija Hafidh, Tawfik A. Besheya, R. Elmehdawi, S. Beshyah
Abstract Objectives  The literature on the impact of Ramadan fasting (RF) on metabolic control and health in people with diabetes is widely spread in many journals making it not readily accessible to those interested in the subject. We aimed to provide a narrative overview of the global literature production in 1 year (2022) on diabetes and RF. Materials and Methods  It is a narrative, non-systematic review of the international literature from a single major medical online database (i.e., PubMed) in one calendar year (2022). Relevant literature was narrated in a concise thematic account. Results  Themes emerged from the review of the literature on RF published in 2022, including a couple of studies on the epidemiology of fasting in the real world by adults and children. Three studies involved some pathophysiological observations of metabolic and other biochemical markers. Several studies assessed the use and safety of different pharmacological therapeutic agents. Certain sulfonylureas, such as modified-release gliclazide, were considered safer than other sulfonylureas. Newer basal insulin analogs were studied in different geographical and socioeconomic settings (Gulf vs. South East Asia). The role of diabetes technology in Ramadan was the focus of several studies of insulin pumps and monitoring. Special themes were high-risk groups, pregnancy, acute complications, postbariatric surgery, and COVID-19 in Ramadan. Few studies examined the safety of sodium-glucose co-transporter-2 inhibitors as a class and individually during RF. Professional and patient perspectives released in 2022 included updated guidelines for adults and adolescents. Conclusion  In 2022's medical literature, RF and diabetes continue to address epidemiology, the burden of diabetes care on fasting patients, and discussions of concerns of patients and healthcare professionals. Risk stratification and issues of high-risk patients are still in focus for children, adolescents, and adults. Approaches to effective management still gather evidence for newer pharmacological agents and diabetes technology.
【摘要】目的斋月禁食(Ramadan fasting, RF)对糖尿病患者代谢控制和健康影响的文献在许多期刊上广泛传播,但对该主题感兴趣的人却很难获得。我们的目标是提供一年内(2022年)关于糖尿病和RF的全球文献生产的叙述性概述。材料和方法这是对一个日历年(2022年)内来自单一主要医学在线数据库(即PubMed)的国际文献的叙述性非系统综述。有关文献以简明扼要的专题叙述。对2022年发表的关于RF的文献进行了回顾,其中包括一些关于成人和儿童在现实世界中禁食流行病学的研究。三项研究涉及代谢和其他生化标志物的病理生理观察。几项研究评估了不同药物治疗药物的使用和安全性。某些磺脲类药物,如改性释放格列齐特,被认为比其他磺脲类药物更安全。新的基础胰岛素类似物在不同的地理和社会经济环境中进行了研究(海湾与东南亚)。糖尿病技术在斋月中的作用是胰岛素泵和监测的几项研究的重点。特别主题是高危人群、妊娠、急性并发症、减肥后手术和斋月期间的COVID-19。很少有研究检查钠-葡萄糖共转运蛋白-2抑制剂作为一类和单独在RF期间的安全性。2022年发布的专业和患者观点包括更新的成人和青少年指南。在2022年的医学文献中,RF和糖尿病继续解决流行病学、禁食患者的糖尿病护理负担以及患者和医疗保健专业人员关注的问题。高危患者的风险分层和问题仍然是儿童,青少年和成人的重点。有效管理的方法仍在收集新的药物和糖尿病技术的证据。
{"title":"Ramadan Fasting and Diabetes (2022): The Year in Review","authors":"Khadija Hafidh, Tawfik A. Besheya, R. Elmehdawi, S. Beshyah","doi":"10.1055/s-0043-1764458","DOIUrl":"https://doi.org/10.1055/s-0043-1764458","url":null,"abstract":"Abstract Objectives  The literature on the impact of Ramadan fasting (RF) on metabolic control and health in people with diabetes is widely spread in many journals making it not readily accessible to those interested in the subject. We aimed to provide a narrative overview of the global literature production in 1 year (2022) on diabetes and RF. Materials and Methods  It is a narrative, non-systematic review of the international literature from a single major medical online database (i.e., PubMed) in one calendar year (2022). Relevant literature was narrated in a concise thematic account. Results  Themes emerged from the review of the literature on RF published in 2022, including a couple of studies on the epidemiology of fasting in the real world by adults and children. Three studies involved some pathophysiological observations of metabolic and other biochemical markers. Several studies assessed the use and safety of different pharmacological therapeutic agents. Certain sulfonylureas, such as modified-release gliclazide, were considered safer than other sulfonylureas. Newer basal insulin analogs were studied in different geographical and socioeconomic settings (Gulf vs. South East Asia). The role of diabetes technology in Ramadan was the focus of several studies of insulin pumps and monitoring. Special themes were high-risk groups, pregnancy, acute complications, postbariatric surgery, and COVID-19 in Ramadan. Few studies examined the safety of sodium-glucose co-transporter-2 inhibitors as a class and individually during RF. Professional and patient perspectives released in 2022 included updated guidelines for adults and adolescents. Conclusion  In 2022's medical literature, RF and diabetes continue to address epidemiology, the burden of diabetes care on fasting patients, and discussions of concerns of patients and healthcare professionals. Risk stratification and issues of high-risk patients are still in focus for children, adolescents, and adults. Approaches to effective management still gather evidence for newer pharmacological agents and diabetes technology.","PeriodicalId":294186,"journal":{"name":"Journal of Diabetes and Endocrine Practice","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134057650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Free Communications of The Seventh Qatar Diabetes, Endocrinology, and Metabolic Conference, Doha, Qatar, March 2–4, 3–5, 2023 第七届卡塔尔糖尿病、内分泌和代谢会议,多哈,卡塔尔,2023年3月2-4、3-5日
Pub Date : 2023-04-01 DOI: 10.1055/s-0043-1768976
M. Bashir, Tania Jabir, M. Z. Haq, M. Mokhtar, H. Surchi, Gowri Karuppasamy, Khaled M Dukhan
Abstract These are the abstracts of the free communications of The Seventh Qatar Diabetes, Endocrinology, and Metabolic Conference, Doha, Qatar, March 2–4, 3–5, 2023. The QDEM-7 was a hybrid conference. The declared educational objectives of the congress were to give a “state of the art in endocrine practice.” International and regional key opinion leaders delivered plenary and symposia presentations. In addition, free communications on current research and clinical practice in the region and worldwide were presented . We present here the abstracts of the congress as submitted by the authors of the free communications after minimal restyling and editing to suit the publication requirements of the Journal. We hope that by publishing them in our open-access Journal, we provide early recognition of the work and extend the benefit to those who could not make it to the live presentations.
这些是第七届卡塔尔糖尿病、内分泌和代谢会议的免费通讯摘要,会议将于2023年3月2-4日、3-5日在卡塔尔多哈举行。QDEM-7是一个混合型会议。大会宣布的教育目标是提供“内分泌实践的最新水平”。国际和区域主要意见领袖作了全体会议和专题讨论会的发言。此外,还提供了有关该区域和世界范围内当前研究和临床实践的免费交流。我们在这里展示由自由通讯作者提交的大会摘要,经过最小的重新设计和编辑,以适应《华尔街日报》的出版要求。我们希望通过将它们发表在我们的开放获取期刊上,我们提供了对工作的早期认可,并将利益扩展到那些无法参加现场演示的人。
{"title":"Free Communications of The Seventh Qatar Diabetes, Endocrinology, and Metabolic Conference, Doha, Qatar, March 2–4, 3–5, 2023","authors":"M. Bashir, Tania Jabir, M. Z. Haq, M. Mokhtar, H. Surchi, Gowri Karuppasamy, Khaled M Dukhan","doi":"10.1055/s-0043-1768976","DOIUrl":"https://doi.org/10.1055/s-0043-1768976","url":null,"abstract":"Abstract These are the abstracts of the free communications of The Seventh Qatar Diabetes, Endocrinology, and Metabolic Conference, Doha, Qatar, March 2–4, 3–5, 2023. The QDEM-7 was a hybrid conference. The declared educational objectives of the congress were to give a “state of the art in endocrine practice.” International and regional key opinion leaders delivered plenary and symposia presentations. In addition, free communications on current research and clinical practice in the region and worldwide were presented . We present here the abstracts of the congress as submitted by the authors of the free communications after minimal restyling and editing to suit the publication requirements of the Journal. We hope that by publishing them in our open-access Journal, we provide early recognition of the work and extend the benefit to those who could not make it to the live presentations.","PeriodicalId":294186,"journal":{"name":"Journal of Diabetes and Endocrine Practice","volume":"112 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128643568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Diabetes and Endocrine Practice
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1