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Contributing Reviewers in 2022 2022年投稿审稿人
Pub Date : 2023-01-01 DOI: 10.1055/s-0043-1768142
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引用次数: 0
Incidence and Risk Factors for the Development of New-Onset Diabetes after Kidney Transplantation 肾移植术后新发糖尿病的发生率及危险因素
Pub Date : 2023-01-01 DOI: 10.1055/s-0043-1763275
Jamila S. Elamouri
Abstract Objective  New-onset diabetes mellitus after transplantation (NODAT), also known as posttransplant diabetes mellitus, is a common complication after kidney transplantation. It is associated with an increased risk of graft failure and death. Therefore, minimizing the risk of NODAT is a priority after kidney transplantation. This study aimed to determine the incidence of NODAT, the risk factors for its development, and the therapeutic drugs used for its management. Patients and Methods  This is an observational, retrospective study on kidney recipients who were followed up in our center in 2021. After excluding known diabetic patients, second transplant patients, and those with follow-up periods less than 6 months, 308 recipients were included in the study. Demographic, clinical, and laboratory data were collected from the patient records. The patients were categorized as diabetic or nondiabetic. Results  All patients' mean age was 35.9±11.6 years (standard deviation). The male-to-female ratio was 2.13:1. The overall incidence of NODAT was 38.3%. The median time to NODAT diagnosis was 6 months. Patients older than 40 were more likely to develop NODAT (61.1%; p  = 0.000). The prevalence of pretransplant body mass index (BMI) more than 25 was significantly higher (67.6%) in diabetic than among nondiabetic patients ( p  = 0.000). NODAT patients were more likely to have had a rejection episode (65 vs. 35% in nondiabetic patients; p  = 0.011). A high trough level of calcineurin inhibitors carried a significant risk of NODAT development. Tacrolimus trough level more than or equal to 10 ng/mL had an odds ratio of 57.9 (95% confidence interval [CI] 7.689–1262.2; p  = 0.0007) for the development of NODAT. Likewise, a cyclosporine-A trough level more than or equal to 150 ng/mL had an odds ratio of 100.7 (95% CI: 7.31–4293.5; p  = 0.0028). Conclusion  NODAT incidence was high in this study. Older age, high BMI, prior rejection episode, steroid dose, and high calcineurin inhibitors trough levels were significant risk factors for developing NODAT.
【摘要】目的肾移植术后新发糖尿病(New-onset diabetes after transplantation, NODAT)又称移植后糖尿病,是肾移植术后常见的并发症。它与移植物衰竭和死亡的风险增加有关。因此,降低NODAT的风险是肾移植后的首要任务。本研究旨在确定NODAT的发病率,其发展的危险因素,以及用于治疗的药物。患者和方法这是一项观察性、回顾性研究,研究对象为2021年在我中心随访的肾受体患者。在排除已知的糖尿病患者、第二次移植患者和随访时间少于6个月的患者后,308名受者被纳入研究。从患者记录中收集人口统计、临床和实验室数据。患者分为糖尿病患者和非糖尿病患者。结果所有患者平均年龄为35.9±11.6岁(标准差)。男女比例为2.13:1。NODAT的总发病率为38.3%。诊断为NODAT的中位时间为6个月。40岁以上的患者更容易发生NODAT (61.1%;P = 0.000)。糖尿病患者移植前体重指数(BMI)大于25的患病率(67.6%)明显高于非糖尿病患者(p = 0.000)。NODAT患者更有可能发生排斥反应(65% vs.非糖尿病患者的35%;P = 0.011)。高谷水平的钙调磷酸酶抑制剂具有显著的NODAT发展风险。他克莫司谷水平大于或等于10 ng/mL时,比值比为57.9(95%可信区间[CI] 7.689-1262.2;p = 0.0007)。同样,环孢素a谷水平大于或等于150 ng/mL时,优势比为100.7 (95% CI: 7.31-4293.5;P = 0.0028)。结论本组NODAT发生率较高。年龄较大、高BMI、既往排斥事件、类固醇剂量和高钙调磷酸酶抑制剂谷底水平是发生NODAT的重要危险因素。
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引用次数: 0
Thyroxine Replacement Therapy during Ramadan Fasting: Physicians' and Patients' Perceptions and Practices 斋月期间甲状腺素替代疗法:医生和患者的认知和实践
Pub Date : 2023-01-01 DOI: 10.1055/s-0043-176327
S. Beshyah, Aly B Khalil, A. Beshyah, M. Benbarka, I. Sherif
Abstract Objective  Thyroxine (T4) therapy is taken on an empty stomach and no food is taken for a short period. During Ramadan fasting (RF), Muslim patients may face difficulties taking levothyroxine as recommended. Materials and Methods  We performed a mixed methods study of an online survey of 218 physicians to explore their perceptions and practices. Also, we interviewed a sample of 172 hypothyroid patients to establish their practices and source of information. Their median age was 46 (17–90) years; they had hypothyroidism for a median of 5 years and took a median thyroxine dose of 100 µg daily. Furthermore, we attempted to explore the effects of RF on available thyroid function tests. Results  Consultants were 58.4%, and the most represented specialty was endocrinology, 46.1%. Regarding the impact of RF on T4 therapy, 52.3% thought the RF was not clinically relevant in most patients on T4 replacement. However, 27.5% thought RF affects T4 replacement therapy in a clinically relevant manner. About 77.1% of respondents reported giving advice routinely to all patients on T4 replacement during RF. One hundred sixty-four respondents were split between recommending taking the medications with Iftar , Suhour , or other times. Most respondents (73.9%) do not repeat measurements of thyroid hormone levels after Ramadan unless needed during their scheduled clinic visit. On the other hand, 50.3% of the patients confirmed that their physician advised them to take their thyroxine during Ramadan, whereas 40.4% could not recall receiving any advice. About 59.9% of the patients took thyroxine with Iftar , 23.8% with Suhour , and 16.3% at different times. In those patients where thyroid function tests were available before and after RF, serum thyroid-stimulating hormone and serum-free T4 did not show a specific pattern in the group as a whole and with subgroups. Conclusion  There is variation in the advice that hypothyroid patients receive on taking thyroxine during Ramadan and in their practices. Further studies are needed to determine the best timing for thyroxine replacement.
【摘要】目的甲状腺素(T4)治疗应空腹服用,短时间内不进食。在斋月禁食(RF)期间,穆斯林患者可能难以按照建议服用左甲状腺素。材料和方法我们对218名医生的在线调查进行了一项混合方法研究,以探讨他们的看法和做法。此外,我们还采访了172名甲状腺功能减退患者,以确定他们的做法和信息来源。年龄中位数为46岁(17-90岁);他们患甲状腺功能减退症的平均时间为5年,每天服用甲状腺素的平均剂量为100微克。此外,我们试图探讨射频对现有甲状腺功能测试的影响。结果咨询医师占58.4%,内分泌科占46.1%。对于射频对T4治疗的影响,52.3%的患者认为射频在大多数T4替代患者中没有临床相关性。然而,27.5%的人认为射频对T4替代治疗有临床意义。约77.1%的受访者报告在射频治疗期间对所有患者进行T4置换的常规建议。164名受访者在建议在开斋、斋月或其他时间服用药物之间存在分歧。大多数应答者(73.9%)在斋月后不重复测量甲状腺激素水平,除非在预定的诊所访问期间需要。另一方面,50.3%的患者确认他们的医生建议他们在斋月期间服用甲状腺素,而40.4%的患者不记得接受过任何建议。在不同时间服用甲状腺素的患者分别占59.9%、23.8%和16.3%。在RF前后进行甲状腺功能检查的患者中,血清促甲状腺激素和无血清T4在整个组和亚组中没有显示出特定的模式。结论甲状腺功能减退患者在斋月期间服用甲状腺素的建议和实践存在差异。需要进一步的研究来确定甲状腺素替代的最佳时机。
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引用次数: 0
Lesson of the Week: In the Nick of Time! 本周课程:在关键时刻!
Pub Date : 2023-01-01 DOI: 10.1055/s-0043-1761195
S. Beshyah
Management of diabetes lends itself very well to several classical rules of good clinical practice, an elaborationofwhich is out of the scope of this short story. However, a couple of these are noteworthy. “Diagnosis should precede treatment as much as possible except formeasures of resuscitation” applies to diabetes as to all other conditions. In diabetes, diagnosis and classification are the same. Hence, a serious attempt to classify diabetes at the time of diagnosis or as soon as possible after that ismandatory.1 Inparticular,when thepatient’s characteristics are atypical, or events do not follow the expected course, making assumptions under these circumstances can be very dangerous.2 In this vignette, an unusual case of diabetes in a young woman is presented and discussed with an analysis of lessons to be learned. The present case report exemplifies several themes of “not expecting the expected,” “not making unfounded assumptions,” and “ignoring several alert signals.” In theMerriam-Webster dictionary, the idiom “in the nick of time”means just before the last moment when something can be changed or something terrible will happen.3 Many examples are medical, for instance, “The ambulance arrived in the nick of time” or “The doctor arrived in the nick of time. The patient’s life was saved”. Hence, the choice of the title is not for fun, but it is perhaps thebest description of the case as the story unfolds.
糖尿病的管理很好地适用于临床实践的几个经典规则,对这些规则的详细阐述超出了这篇短篇小说的范围。然而,其中有几个值得注意。“除采取复苏措施外,诊断应尽可能先于治疗”适用于糖尿病和所有其他疾病。糖尿病的诊断和分类是一样的。因此,在诊断时或诊断后尽快对糖尿病进行分类是必须的特别是,当患者的特征是非典型的,或者事件没有按照预期的过程进行时,在这种情况下做出假设可能是非常危险的在这个小插图中,一个不寻常的年轻女性糖尿病病例被提出并讨论与教训的分析。本案例报告举例说明了“不期望预期”、“不做毫无根据的假设”和“忽略几个警报信号”的几个主题。在韦氏词典中,习语“In the nick of time”指的是在事情可以改变或可怕的事情将要发生的最后一刻之前许多例子都是医疗方面的,例如,“救护车及时赶到了”或“医生及时赶到了”。病人的生命得救了。”因此,书名的选择并不是为了好玩,但随着故事的展开,它可能是对案件的最好描述。
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引用次数: 0
A Gulf Association for Endocrinology and Diabetes 11 Years on 海湾内分泌和糖尿病协会成立11年了
Pub Date : 2022-10-01 DOI: 10.1055/s-0043-1761197
W. Hussein, N. Aljuhani
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引用次数: 0
Journal of Diabetes and Endocrine Practice—Five Years On! 糖尿病与内分泌实践杂志- 5年!
Pub Date : 2022-10-01 DOI: 10.1055/s-0043-1761196
S. Beshyah
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引用次数: 1
Vitamin D and Bone Health 2022: Is the Evidence Pendulum Switching Backward on Its Benefits? 维生素D和骨骼健康2022:证据钟摆倒转到它的好处吗?
Pub Date : 2022-10-01 DOI: 10.1055/s-0043-1763273
H. Saadi
Abstract Objectives:  This concise article aims to (a) review the role of vitamin D in bone health, (b) discuss the consequences of vitamin D deficiency, (c) analyze the use of vitamin D to prevent and treat osteoporosis and (d) explore if the evidence pendulum is switching back on the beneficial effects of vitamin D. Materials and Methods:  A narrative nonsystematic review of the literature was done thematically to answer the questions stated in the objectives above. Results:  A literature review suggests that vitamin D deficiency can be a real clinical condition that warrants recognition and management, particularly in high-risk groups. The optimal vitamin D level is likely more than or equal to 50 nmol/L (20 ng/mL). The established consequences of vitamin D deficiency in adults include osteomalacia and osteoporosis. Moreover, whether vitamin D supplementation reduces falls and fractures in subjects with baseline vitamin D more than 50 nmol/L (20 ng/mL) is not confirmed. However, vitamin D supplementation is still needed for patients with osteoporosis and those at increased risk of vitamin D deficiency. Finally, there is no justification for measuring 25-hydroxyvitamin D in the general population. Conclusions:  For patients at increased risk for osteoporosis, those with vitamin D deficiency, or both, it remains reasonable to consider vitamin D supplementation (800–1,000 IU/d or more), consistent with recommendations of multiple societies.
摘要目的:这篇简明的文章旨在(a)回顾维生素D在骨骼健康中的作用,(b)讨论维生素D缺乏的后果,(c)分析维生素D在预防和治疗骨质疏松症中的应用,以及(D)探索证据是否正倒转到维生素D的有益作用上。材料和方法:对文献进行叙述性的非系统回顾,以回答上述目标中提出的问题。结果:一项文献综述表明,维生素D缺乏症可能是一种真正的临床状况,值得认识和管理,特别是在高危人群中。最佳维生素D水平可能大于或等于50 nmol/L (20 ng/mL)。成年人缺乏维生素D的后果包括骨软化症和骨质疏松症。此外,在基线维生素D超过50 nmol/L (20 ng/mL)的受试者中,补充维生素D是否能减少跌倒和骨折尚未得到证实。然而,骨质疏松症患者和维生素D缺乏风险增加的患者仍然需要补充维生素D。最后,没有理由在普通人群中测量25-羟基维生素D。结论:对于骨质疏松症风险增加的患者,维生素D缺乏症患者,或两者兼而有之的患者,考虑补充维生素D (800-1,000 IU/ D或更多)仍然是合理的,与多个学会的建议一致。
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引用次数: 0
Free Communications of the Tenth Gulf Association of Endocrinology and Diabetes Annual Congress, Riyadh, Saudi Arabia, November 3–5, 2022 第十届海湾内分泌与糖尿病协会年会自由通讯,沙特阿拉伯利雅得,2022年11月3-5日
Pub Date : 2022-10-01 DOI: 10.1055/s-0043-1763279
Khaled Al Dahmani, B. Afandi, T. Elhadd, W. Hussein
,
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引用次数: 1
Physicians' and Patients' Perceptions and Practices Concerning Antithyroid Drug-Induced Agranulocytosis 医生和患者对抗甲状腺药物性粒细胞缺乏症的认知和实践
Pub Date : 2022-10-01 DOI: 10.1055/s-0043-1761438
S. Beshyah, A. E. Bashier, B. Afandi, Mohammed Naman Mohammed, E. Abdelgadir, A. Beshyah
Abstract Objectives  We aimed to ascertain physicians' attitudes and practices and evaluate patients' knowledge of antithyroid drugs (ATDs). Also, we would like to review the quality of patients' information on the Internet (in Arabic) concerning ATDs' including agranulocytosis. Methods  A mixed methods study design was employed, including an online physician questionnaire, structured interviews of patients on ATDs, and evaluation on web sites containing patients' information in Arabic. Results  Most physicians (82.6%) thought the frequency of agranulocytosis in patients receiving antithyroid medications is 1 to 5 per 1,000 per annum. Nearly 72% of the participants reported educating their patients about the risk of agranulocytosis when they receive ATDs regularly verbally only. Most physicians thought patients should be warned about sore throat and fever. More participants would measure a white blood cell (WBC) count only if a patient developed suggestive symptoms (57.0%) than those who do it routinely (43.0%). If a patient receiving ATDs develops suspicious symptoms, participants thought that the most efficient way to deal with this is to attend the nearest hospital emergency department (37.2%). Less thought they can go to any facility with a laboratory that can do WBC count (29.8%) or contact their usual endocrine clinic (24.4%). Nearly half of the patients (49%) were aware of the side effects of ATDs, but only 17 respondents (17.3%) identified one or both of the two most typical symptoms of agranulocytosis. The quality of the information received was evaluated as “not good at all” or “poor” by 19.2%. Over two-thirds (69.7%) of participants thought the amount of information was about right. Most participants (72.5%) preferred receiving information on side effects during consultations with their physicians. Since starting ATDs, 37.0% of patients have experienced different symptoms suggestive of agranulocytosis in various combinations. However, only one-third (12/37) had an urgent blood count. A review of 190 selected Arabic patient information Internet sites revealed a significant variation in patient advice. Six percent 11/190 (5.8%) of the sites can be considered good. Conclusions  The findings of suboptimal and inconsistent perceptions and practices of physicians and patients put patients with ATD in the Middle East at increased risk and call for more action from professional and patient advocacy groups.
摘要目的了解医生对抗甲状腺药物的态度和做法,并评价患者对抗甲状腺药物(ATDs)的认知。此外,我们希望回顾互联网(阿拉伯语)上关于ATDs(包括粒细胞缺乏症)的患者信息的质量。方法采用混合方法的研究设计,包括在线医生问卷,对ATDs患者进行结构化访谈,以及对包含阿拉伯语患者信息的网站进行评估。结果大多数医生(82.6%)认为接受抗甲状腺药物治疗的患者出现粒细胞缺乏症的频率为1 ~ 5 / 1000。近72%的参与者报告说,当他们定期口头接受ATDs时,他们会教育患者有关粒细胞缺乏症的风险。大多数医生认为应该提醒病人注意喉咙痛和发烧。只有在患者出现暗示症状时才测量白细胞(WBC)计数的参与者(57.0%)比常规检测的参与者(43.0%)要多。如果接受ATDs治疗的患者出现可疑症状,参与者认为最有效的处理方法是到最近的医院急诊科就诊(37.2%)。较少的人认为他们可以去任何有白细胞计数实验室的机构(29.8%)或联系他们通常的内分泌诊所(24.4%)。近一半的患者(49%)意识到ATDs的副作用,但只有17名受访者(17.3%)确定了粒细胞缺乏症的两种最典型症状中的一种或两种。收到的信息质量评价为“完全不好”或“差”的占19.2%。超过三分之二(69.7%)的参与者认为信息量大致正确。大多数参与者(72.5%)更愿意在咨询医生时获得有关副作用的信息。自ATDs开始以来,37.0%的患者经历了不同组合的提示粒细胞缺乏症的不同症状。然而,只有三分之一(12/37)有紧急血液计数。对190个选定的阿拉伯患者信息互联网站点的回顾揭示了患者建议的显著差异。6 /190(5.8%)的网站可以被认为是好的。医生和患者的不理想和不一致的认知和实践的发现使中东的ATD患者面临更高的风险,并呼吁专业和患者倡导团体采取更多行动。
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引用次数: 0
Guidelines on the Management of Type 2 Diabetes 2型糖尿病管理指南
Pub Date : 2022-10-01 DOI: 10.1055/s-0043-1761205
M. Fisher
The Emirates Diabetes Society (EDS) consensus guidelines for the management of type 2 diabetes were published in 2020.1 To produce the consensus guideline, the EDS convened a panel of experts who were tasked with adapting key research findings and international guidelines for local use. The final publication was reviewed by the panel and represented its collective analysis and recommendations. It was particularly based on the 2019 guideline on diabetes, prediabetes, and cardiovascular disease produced by the European Association for the Study of Cardiology (ESC) in collaboration with the European Association for the Study of Diabetes (EASD),2 and on the 2020 Standards of Care from the American Diabetes Association (ADA).3 The process was facilitated by an unrestricted grant from Novo Nordisk who did not participate in any of the meetings or the drafting of the manuscript. Key recommendations were made on screening, interventions for prediabetes, structured education, physical activity, nutrition therapy, and pharmacotherapy. The recommendations on pharmacotherapy took account of the person’s risk of cardiovascular disease. How do the EDS consensus guidelines compare with other guidelines and consensus statements on the management of type 2 diabetes, and what approaches could be taken when the EDS consensus guidelines are reviewed? What Are Guidelines and Consensus Statements?
阿联酋糖尿病协会(EDS)关于2型糖尿病管理的共识指南于2020年发布,为了制定共识指南,EDS召集了一个专家小组,负责调整关键研究成果和国际指南以供当地使用。小组审查了最后的出版物,它代表了小组的集体分析和建议。它特别基于欧洲心脏病研究协会(ESC)与欧洲糖尿病研究协会(EASD)合作制定的2019年糖尿病、前驱糖尿病和心血管疾病指南2,以及美国糖尿病协会(ADA)的2020年护理标准3该过程得到了诺和诺德的无限制资助,诺和诺德没有参加任何会议或手稿的起草。主要建议包括筛查、糖尿病前期干预、有组织的教育、体育活动、营养治疗和药物治疗。关于药物治疗的建议考虑了患者患心血管疾病的风险。EDS共识指南与其他关于2型糖尿病管理的指南和共识声明相比如何?在审查EDS共识指南时可以采取哪些方法?什么是指导方针和共识声明?
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引用次数: 2
期刊
Journal of Diabetes and Endocrine Practice
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