Current Research in Green and Sustainable Chemistry最新文献

{"title":"Sustainable nanohybrid modified polyphenylsulfone ultrafiltration membranes for efficient protein separation","authors":"H.R. Panchami ,&nbsp;Arun M. Isloor ,&nbsp;B.M. Dodamani ,&nbsp;A.M. Vijesh","doi":"10.1016/j.crgsc.2025.100500","DOIUrl":"10.1016/j.crgsc.2025.100500","url":null,"abstract":"<div><div>Present work describes the development of performance enhancement of polyphenylsulfone (PPSU) membranes by incorporating polyaniline nanofiber-bentonite (PANI-bentonite) nanohybrid in the membrane matrix via immersion precipitation method, as an effective strategy for removing proteins from contaminated water. The hydrophilic PANI-bentonite nanohybrid was successfully synthesized and characterized. Several instrumental techniques like SEM, AFM, TEM, EDX and BET analysis were used to study the morphological changes during the incorporation of nanohybrid in the PPSU membranes. Experimental results revealed that hydrophilic PANI-bentonite content in the membrane is responsible for the formation of an effective cavities in the composite membranes and enhanced properties like porosity, hydrophilicity and water intake abilities of the modified PPSU composite membranes. Moreover, inclusion of PANI-bentonite nanohybrid increased the permeability and showed the highest results for PBM-2 membrane, which showed a permeability of 181 Lm⁻²h⁻¹ bar⁻¹ compared to the pristine membrane with a permeability 106 Lm⁻²h⁻¹ bar⁻¹. The outcomes of the various studies showed that the nanocomposite membrane's fouling resistance increased from 51.4 % for the pristine membrane to 82.8 % for the PBM-2 membrane. Protein filtration efficiency analysis of the developed membranes revealed that PBM-2 membrane with 1 w% PANI-bentonite has high rejection for BSA, egg albumin and pepsin, exhibited 96.7 %, 95.2 % and 68.8 % efficiencies respectively.</div></div>","PeriodicalId":296,"journal":{"name":"Current Research in Green and Sustainable Chemistry","volume":"12 ","pages":"Article 100500"},"PeriodicalIF":0.0,"publicationDate":"2025-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145750215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase separation behaviour during direct solvent extraction of Corynebacterium glutamicum fermentation broth – Systematic study of crud suppression","authors":"Jörg Eberz ,&nbsp;Lara Strehl ,&nbsp;Marcel Mann ,&nbsp;Andreas Jupke ,&nbsp;Jørgen Barsett Magnus","doi":"10.1016/j.crgsc.2025.100448","DOIUrl":"10.1016/j.crgsc.2025.100448","url":null,"abstract":"<div><div>The economic competitiveness of bio-based production processes is often hindered by the high costs associated with downstream processing, compared to fossil-based methods. Liquid-liquid extraction is a widely used technique for aqueous fermentation systems and offers significant cost-saving potential, especially if extraction could be performed directly from the fermentation broth without prior cell separation. However, this is often hindered by the formation of \"crud\" — a deposit or emulsion at the interface between two partially settled phases. This study investigates the liquid-liquid phase separation of <em>Corynebacterium glutamicum</em> DM 1933 fermentation broths using five different solvents. We systematically examined the impact of cell surface properties, modified through nutrient concentration, on crud formation. In addition, the variation in salt concentration and pH after fermentation was analysed. Our findings show that the present nutrient concentration influences the cell surface properties and, consequently, crud formation. A more hydrophilic cell surface was present at a lower phosphate concentration, whereas a more hydrophobic cell surface was measured for a lower nitrogen and iron concentration. With a more hydrophobic cell surface, the fermentation broth showed a large crud phase, while a decrease in crud formation could be seen for fermentation broths with a more hydrophilic cell surface. Furthermore, the crud formation is influenced by the pH, cell and salt concentration and strongly by the used solvent.</div></div>","PeriodicalId":296,"journal":{"name":"Current Research in Green and Sustainable Chemistry","volume":"10 ","pages":"Article 100448"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facile preparation of zeolite Na–P supported by nanozinc oxide for antibacterials","authors":"Sakesit Duangkham ,&nbsp;Rattana Pengproh ,&nbsp;Pattaranun Thuadaij","doi":"10.1016/j.crgsc.2025.100459","DOIUrl":"10.1016/j.crgsc.2025.100459","url":null,"abstract":"<div><div>This research presents facile and short-time synthesis of zeolite Na–P supported by nanozinc oxide (nano-ZnO), demonstrating significant progress in developing antibacterial agents. Zeolites Na–P synthesized from Narathiwat kaolinite and silica derived from sugarcane bagasse ash were prepared by refluxing at 100 °C for 8 h. The zeolites Na–P were then functionalized with nano-ZnO in concentrations of 1 % w/w, 3 % w/w, and 5 % w/w in an ultrasound bath at 70 °C for 15 min and stirred with 1400 rpm at 70 °C for 3 h to form nanocomposites. The composites were characterized using X-ray diffraction, Fourier-transform infrared spectroscopy, and scanning electron microscopy, which confirmed the successful integration of nano-ZnO without affecting the crystal structure of the zeolites. The antibacterial efficacy of the synthesized nanocomposites against various gram-positive and gram-negative bacteria, including <em>Staphylococcus aureus</em> and <em>Escherichia coli</em>, was evaluated using the disc diffusion method. The zeolites loaded with 3 % w/w nano-ZnO exhibited the highest antibacterial activity, outperforming the other formulations. The potential of zeolites Na–P is supported by nano-ZnO as a highly effective antibacterial agent, which has important implications for applications in healthcare and environmental remediation.</div></div>","PeriodicalId":296,"journal":{"name":"Current Research in Green and Sustainable Chemistry","volume":"10 ","pages":"Article 100459"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring biogenic/ green solvents on the sustainable development of metal organic frameworks for waste water treatment","authors":"Rajeev Agrawal ,&nbsp;Urmila Chakraborty ,&nbsp;Saurabh Singh","doi":"10.1016/j.crgsc.2025.100462","DOIUrl":"10.1016/j.crgsc.2025.100462","url":null,"abstract":"<div><div>The application of metal organic frameworks (MOFs) in the field of wastewater treatment has gained significant scientific focus in the recent years. However, the use of hazardous solvents during the synthesis of MOFs restrains their large scale synthesis and industrial level applications. Thus green and safer solvents are required, which can efficiently replace the toxic solvents conventionally used during the synthesis of MOFs. The application of cleaner green solvents can cause drastic alleviation in the toxic wastes produced from the industrial scale synthesis of MOFs. Many green solvents (bio-derived and non-bio-derived) have found their applications in different areas of scientific research. Green solvents, such as water, super critical CO₂, ionic liquids, deep-eutectic solvents, certain alcohols, gamma-valerolactone and cyrene have been efficiently explored for the synthesis of different types of MOFs suitable for waste water treatment. This review highlights the application of these solvents for the engineering of MOFs for water treatment. The research works from the last eight years (2018–2025) involving the use of suitable biogenic/green solvents for the synthesis of MOFs specifically applicable for water/wastewater treatment applications have been reviewed intricately for the first time. The challenges associated with the application of these solvents have been presented in detail. The recent strategies adopted by the researchers to overcome the existing challenges and obtain high quality MOFs in these solvents have been discussed.</div></div>","PeriodicalId":296,"journal":{"name":"Current Research in Green and Sustainable Chemistry","volume":"10 ","pages":"Article 100462"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A green templated and nitrogen-incorporated SAPO-34 catalyst for enhanced MTO performance","authors":"Mohammad Javad Emami,&nbsp;Jafar Towfighi Darian,&nbsp;Masoud Safari Yazd","doi":"10.1016/j.crgsc.2025.100463","DOIUrl":"10.1016/j.crgsc.2025.100463","url":null,"abstract":"<div><div>This study presents a nitrogen-modified SAPO-34 catalyst (SPG), synthesized via a green templated method using coffee powder, to improve the efficiency and stability of the methanol-to-olefins (MTO) process. Compared to conventional SAPO-34 (SP), SPG demonstrates enhanced selectivity, stability, and longevity. Characterization shows a smaller crystallite size (38 nm vs. 46 nm), increased nitrogen incorporation, and well-distributed active sites, improving catalytic activity. Optimized acidity in SPG enhances methanol conversion while reducing coke formation. MD simulations reveal that nitrogen modification improves methanol retention and adsorption energy, promoting ethylene production. Performance tests show SPG achieving 92.6 % light olefin selectivity for 360 min, outperforming SP. Additionally, SPG exhibits superior hydrothermal stability and reduced coke deposition, making it a promising eco-friendly and cost-effective catalyst for industrial MTO applications.</div></div>","PeriodicalId":296,"journal":{"name":"Current Research in Green and Sustainable Chemistry","volume":"10 ","pages":"Article 100463"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crystalline defenders: Silver nanoparticles as a new front in antimicrobial warfare","authors":"Sabreena Jan ,&nbsp;Nayeema Jan ,&nbsp;Seema Singh ,&nbsp;Muhammad Ashraf Shah ,&nbsp;Mansoor Ahmad Malik","doi":"10.1016/j.crgsc.2025.100481","DOIUrl":"10.1016/j.crgsc.2025.100481","url":null,"abstract":"<div><div>The field of nanotechnology is capturing the attention of more and more researchers in their scholarly investigations. The presence of biologically active compounds in medicinal plants makes them an excellent choice for the synthesis of nanoparticles. This paper details the formation of crystalline silver nanoparticles (AgNPs) using a simple and environmentally friendly green synthesis technique. The nanoparticles were synthesized using plant extract of <em>Taxus wallichiana</em> as the reducing agent. Various analytical methods, including X-Ray Diffraction (XRD), UV–Visible spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), and Field Emission Scanning Electron Microscopy (FESEM), were employed to investigate the size and structure of the synthesized particles. The as-synthesized AgNPs exhibited a prominent absorption peak at 425 nm. The FTIR spectrum of the AgNPs featured multiple spectral bands across the 300–4000 cm⁻¹ region. XRD analysis confirmed the successful formation of silver nanoparticles, with the synthesized sample exhibiting distinct diffraction peaks at 2θ values of 37.09°, 43.29°, 65.32°, and 76.40°. The biosynthesized AgNPs formed spherical aggregates at the nanoscale, with particle diameters ranging from approximately 60 to 80 nm as revealed by FESEM. They were found to be effective against a variety of fungal pathogens, such as <em>Aspergillus niger</em>, <em>A. fumigatus</em>, <em>Fusarium oxysporum</em>, and <em>Penicillium expansum</em>, as well as bacterial strains including <em>Staphylococcus aureus</em>, <em>Escherichia coli</em>, <em>Proteus vulgaris</em>, and <em>Klebsiella pneumoniae</em>. The nanoparticles demonstrated inhibition zones of varying diameters at different concentrations, with Nystatin and Kanamycin serving as positive controls for the fungal and bacterial species, respectively. The largest inhibition zone (18.42 ± 0.43 mm) was observed at the highest dose (0.4 mg/ml) for <em>Penicillium expansum</em>, while the smallest (10.18 ± 0.13 mm) was noted at the lowest dose (0.2 mg/ml) for <em>Aspergillus niger</em>. For bacteria, the highest dose (2.5 mg/ml) produced the largest inhibition zone (12.78 ± 0.17 mm) in <em>Klebsiella pneumoniae</em>, while the lowest dose (l.9 mg/ml) led to the smallest inhibition zone (8.85 ± 0.25 mm) in <em>Proteus vulgaris</em>. The study revealed that the synthesized nanoparticles showed greater inhibition against fungal species than against bacterial species. This study provides evidence that green-synthesized AgNPs from the leaf extract of <em>Taxus wallichiana</em> can be effective against a wide range of pathogen species.</div></div>","PeriodicalId":296,"journal":{"name":"Current Research in Green and Sustainable Chemistry","volume":"11 ","pages":"Article 100481"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-friendly chromium(VI) cleanup: Guava seed biosorbent performance in equilibrium, kinetic, and thermodynamic studies","authors":"A. Hashem,&nbsp;A. Amr,&nbsp;E.S. Abdel-Halim,&nbsp;S. Farag,&nbsp;A.A. Aly","doi":"10.1016/j.crgsc.2025.100492","DOIUrl":"10.1016/j.crgsc.2025.100492","url":null,"abstract":"<div><div>The contamination of water resources by toxic hexavalent chromium (Cr(VI)) poses significant environmental and health risks. This study explores the potential of guava seed powder (GSP), an agricultural byproduct, as a sustainable biosorbent for Cr(VI) removal. Comprehensive characterization using FTIR, SEM-EDX, XRD, and BET analysis revealed GSP's mesoporous structure (98.7 m²/g surface area) and abundant oxygen-containing functional groups (─OH, ─COOH), which facilitate effective Cr(VI) binding. Batch adsorption experiments demonstrated optimal removal (&gt;85 %) at pH 2 and 30 °C, with equilibrium data best described by the Sips isotherm (R² = 0.990), indicating a maximum adsorption capacity of 3.0 mg/g. Kinetic analysis confirmed chemisorption as the dominant mechanism (pseudo-second-order model, R² = 0.985), while thermodynamic studies revealed the process to be exothermic (ΔH° = −8.72 kJ/mol) and spontaneous (ΔG° = −21.62 to −23.32 kJ/mol). The adsorption mechanism involved electrostatic attraction, surface complexation, and pore diffusion. Comparative analysis highlighted GSP's superior performance over other low-cost biosorbents, underscoring its potential as an eco-friendly and cost-effective solution for Cr(VI) remediation. This work not only advances sustainable water treatment but also aligns with circular economy principles by valorizing agricultural waste.</div><div>A preliminary cost analysis confirmed the exceptional economic viability of GSP, with production costs estimated at $1.5–3.0 per kg, underscoring its potential as a low-cost and sustainable alternative to commercial adsorbents for large-scale wastewater treatment.</div></div>","PeriodicalId":296,"journal":{"name":"Current Research in Green and Sustainable Chemistry","volume":"11 ","pages":"Article 100492"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choline chloride/glycerol/l-arginine (TNADES) as a new sustainable solvent catalyst reaction media in multicomponent synthesis of biological corestones of 2,3-dihydroquinazolin-4(1H)-ones, spiro-2-oxindoles and pyrazole-4-carbonitriles under mild conditions","authors":"Laleh Golestanifar,&nbsp;Ali Reza Sardarian","doi":"10.1016/j.crgsc.2025.100494","DOIUrl":"10.1016/j.crgsc.2025.100494","url":null,"abstract":"<div><div>Ternary natural deep eutectic solvent (TNADES) made of choline chloride, glycerol, and <span>l</span>-arginine was used as an efficient, new reusable solvent/catalyst media for (i) the synthesis of 2-substituted-2,3-dihydroquinazolin-4(1<em>H</em>)-ones through eco-friendly one-pot three-component reaction involving isatoic anhydride, ammonium acetate, various aldehydes or ketones, (ii) synthesis of spirooxindoles consisting of different isatines, malononitrile, and various nucleophiles such as 1,3-dicarbonyl compounds/4<em>H</em> coumarin/α-naphthol, and (iii) the synthesis of pyrazole-4-carbonitriles using the most common raw materials such as phenylhydrazine, malononitrile, or ethyl cyanoacetate and various aldehydes under similar conditions. This solvent/catalyst media is easily and atomic economically synthesized and characterized by FT-IR, TGA, DSC, CV, viscosity, density, refractive index, ionic conductivity, potential of hydrogen (pH), and optical activity. The advantages of this method are the use of recyclable natural and environmentally friendly DES as a dual solvent/catalyst mixture, good to excellent efficiency, and safe and clean operation.</div></div>","PeriodicalId":296,"journal":{"name":"Current Research in Green and Sustainable Chemistry","volume":"11 ","pages":"Article 100494"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145462787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cockle-shell biowaste as a low-cost renewable source for synthesis of calcium acetate monohydrate as a precursor of quasi-amorphous calcium pyrophosphate hydrate","authors":"Somphob Thompho ,&nbsp;Nongnuch Laohavisuti ,&nbsp;Chaowared Seangarun ,&nbsp;Banjong Boonchom ,&nbsp;Pesak Rungrojchaipon ,&nbsp;Wimonmat Boonmee ,&nbsp;Somkiat Seesanong ,&nbsp;Sirichet Punthipayanon","doi":"10.1016/j.crgsc.2025.100485","DOIUrl":"10.1016/j.crgsc.2025.100485","url":null,"abstract":"<div><div>Calcium-rich seashell wastes can be used as renewable materials to prepare value-added compounds. This work proposed an eco-environmental preparation of calcium pyrophosphate by using cockle-shell biowaste as a low-cost renewable calcium source for the first time. Cockle shell was first ground, obtaining calcium carbonate (CaCO₃) powders, which were then used as the renewable material to synthesize calcium acetate monohydrate (Ca(CH₃COO)₂·H₂O) via acetic acid reaction. After that, cockle-derived calcium acetate monohydrate was subsequently prepared as a solution to synthesize calcium pyrophosphate (Ca₂P₂O₇·xH₂O) via a simple precipitation process with tetrasodium pyrophosphate decahydrate (Na₄P₂O₇·10H₂O). The physicochemical characteristics of the synthesized calcium acetate precursor and its calcium pyrophosphate product were investigated by X-ray fluorescence, X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetry, and scanning electron microscopy. The characterization results demonstrate that cockle shell powder (CaCO₃) is a potentially renewable source for the preparation of triclinic calcium acetate with the chemical formula of Ca(CH₃COO)₂·H₂O, which was further used as the precursor to form value-added amorphous calcium pyrophosphate with the chemical formula of Ca₂P₂O₇·4H₂O. This approach not only demonstrates the feasibility of using biogenic Ca-sources for material synthesis but also offers an environmentally friendly process with potential long-term benefits in reducing environmental issues, promoting sustainable chemical production, and increasing value to the underused biowaste.</div></div>","PeriodicalId":296,"journal":{"name":"Current Research in Green and Sustainable Chemistry","volume":"11 ","pages":"Article 100485"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145262299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytosynthesized bimetallic gold-copper nanoparticles using Anacardium occidentale leaf extract and its potential antidiabetic activity","authors":"Ojeyemi Matthew Olabemiwo ,&nbsp;Galadima John ,&nbsp;Abel Kolawole Oyebamiji ,&nbsp;Sunday Adewale Akintelu","doi":"10.1016/j.crgsc.2025.100489","DOIUrl":"10.1016/j.crgsc.2025.100489","url":null,"abstract":"<div><div>This study describes the anti-diabetic property of gold-copper nanoparticles (Au-CuNPs) synthesized using <em>Anacardium occidentale</em> leaf extract. The synthesized Au-NPs was characterized with UV–UV-Visible spectroscopic technique, Fourier-transform infrared spectroscopy, Transmission electron microscopy, X-ray diffraction, and Energy-dispersive X-ray spectroscopy. The formation of the Au-NPs was confirmed by the two distinct peaks on the UV–UV-Visible spectrum at 278 and 532 nm, which correspond to the absorbance of Cu and AuNPs, respectively. The FTIR analysis revealed the involvement of biomolecules with –OH, –NH, –C<img>O, and aromatic –C<img>C- among other functional groups in the <em>Anacardium occidentale</em> leaf extract as the reducing and capping agents. Transmission electron microscopy and X-ray diffraction analysis confirmed the synthesized Au-CuNPs as spherical and crystalline, with particle size in the range of 2–37 nm. The biosynthesized Au-CuNPs displayed effective inhibition against α-amylase and α-glucosidase. At 100 μg/mL, the percentage inhibition of <em>Anacardium occidentale</em> leaf extract, biosynthesized Au-CuNPs, and acarbose was 21, 66, and 80 % against <em>α</em>-amylase and 37, 75, and 83 % against <em>α</em>-glucosidase. The IC₅₀ values of <em>Anacardium occidentale</em> leaf extract, biosynthesized Au-CuNPs, and Acarbose were 149, 50, and 35, against the α-glucosidase and 128.74, 46.16, and 28.40 against α-amylase, respectively. The order of inhibition against α-glucosidase and α-amylase was acarbose &gt; biosynthesized Au-CuNPs &gt; <em>Anacardium occidentale</em> leaf extract. The results show that the biosynthesized Au-CuNPs exhibited a significant level of inhibition against <em>α</em>-glucosidase and α-amylase. This result revealed that Au-CuNPs biosynthesized from <em>Anacardium occidentale</em> leaf extract could be a potential candidate to combat diabetes.</div></div>","PeriodicalId":296,"journal":{"name":"Current Research in Green and Sustainable Chemistry","volume":"11 ","pages":"Article 100489"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145216532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}