{"title":"Mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes: modern views on the problem","authors":"K. I. Perveieva, O. Kalbus","doi":"10.30978/unj2019-1-66","DOIUrl":"https://doi.org/10.30978/unj2019-1-66","url":null,"abstract":"","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131827769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psycho-emotional status and vegetative resistance in patients with chronic cerebral ischemia on the background of angina pectoris","authors":"N. Inhula","doi":"10.30978/UNJ2018-3-39","DOIUrl":"https://doi.org/10.30978/UNJ2018-3-39","url":null,"abstract":"","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"381 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113993916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Body temperature is one of the parameters needed to assess the vital activity of the human body, one of the flexible constant of assessing a person’s homeostasis. The article deals with the anatomical and physiological features of the thermoregulation center — the hypothalamus, which establishes a constant equilibrium of heat production and heat transfer, that allows maintaining body temperature in optimal for the life of the organism limits. Principal differences in the pathogenesis of conditions with an increase in body temperature are distinguished.
{"title":"Thermoregulation of the human body: norm and pathology","authors":"V. Bobrova, S. Nikiforov, L. Shevchenko","doi":"10.30978/UNJ2018-3-17","DOIUrl":"https://doi.org/10.30978/UNJ2018-3-17","url":null,"abstract":"Body temperature is one of the parameters needed to assess the vital activity of the human body, one of the flexible constant of assessing a person’s homeostasis. The article deals with the anatomical and physiological features of the thermoregulation center — the hypothalamus, which establishes a constant equilibrium of heat production and heat transfer, that allows maintaining body temperature in optimal for the life of the organism limits. Principal differences in the pathogenesis of conditions with an increase in body temperature are distinguished.","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131229194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective — to determine the effectiveness of complex treatment in patients with restless leg syndrome due to diabetic polyneuropathy by means of actigraphy and diagnostic scales. Methods and subjects. 43 patients with diabetic polyneuropathy, demonstrating the absence of gabapentin treatment effectiveness, were diagnosed with restless legs syndrome using the main and auxiliary diagnostic criteria. Patients were divided into 2 groups. Patients of the I group (n = 21) received pramipexole, patients of the second group (n = 22) received pramipexole in combination with zopiclone. The patients were interviewed on the international restless legs scale and the Epworth drowsiness scale. To objectify the manifestations and the treatment effectiveness all patients underwent actigraphy on admission and 30 days after the treatment. Results of the research and their discussion. While determining the dynamics of periodic limb movement index during sleep, it was found that it decreased in both groups and was 6.87 ± 0.02 versus 16.29 ± 0.13 before treatment in I group (p < 0.05) and 4.79 ± 0.04 versus 17.34 ± 0.12 before treatment in ІІ group (p < 0.05). According to the Epworth scale, the reduction of the scale score in both groups was found. In patients of the I group after treatment it was 7.86 ± 0.12 points, that is typical for the moderate drowsiness, as opposed to the ІІ group, where the scale score reduced to the 4.43 ± 0.13 points, which is typical for normal sleep (p < 0.05). Conclusions. The findings proved that the monotherapy with pramipexole improves the condition of the patients with restless leg syndrome, reducing the motor component of the disease, but does not significantly affect sleep. Therefore, the combination of pramipexole with zopiclone is more effective, which improves the sleep, reduces daytime sleepiness and positively affects the quality of patients life.
{"title":"Actigraphy as a marker for therapy efficacy in patients with restless legs syndrome against the background of diabetic polyneuropathy","authors":"N. Tkachuk, V. Gryb","doi":"10.30978/UNJ2018-3-46","DOIUrl":"https://doi.org/10.30978/UNJ2018-3-46","url":null,"abstract":"Objective — to determine the effectiveness of complex treatment in patients with restless leg syndrome due to diabetic polyneuropathy by means of actigraphy and diagnostic scales. Methods and subjects. 43 patients with diabetic polyneuropathy, demonstrating the absence of gabapentin treatment effectiveness, were diagnosed with restless legs syndrome using the main and auxiliary diagnostic criteria. Patients were divided into 2 groups. Patients of the I group (n = 21) received pramipexole, patients of the second group (n = 22) received pramipexole in combination with zopiclone. The patients were interviewed on the international restless legs scale and the Epworth drowsiness scale. To objectify the manifestations and the treatment effectiveness all patients underwent actigraphy on admission and 30 days after the treatment. Results of the research and their discussion. While determining the dynamics of periodic limb movement index during sleep, it was found that it decreased in both groups and was 6.87 ± 0.02 versus 16.29 ± 0.13 before treatment in I group (p < 0.05) and 4.79 ± 0.04 versus 17.34 ± 0.12 before treatment in ІІ group (p < 0.05). According to the Epworth scale, the reduction of the scale score in both groups was found. In patients of the I group after treatment it was 7.86 ± 0.12 points, that is typical for the moderate drowsiness, as opposed to the ІІ group, where the scale score reduced to the 4.43 ± 0.13 points, which is typical for normal sleep (p < 0.05). Conclusions. The findings proved that the monotherapy with pramipexole improves the condition of the patients with restless leg syndrome, reducing the motor component of the disease, but does not significantly affect sleep. Therefore, the combination of pramipexole with zopiclone is more effective, which improves the sleep, reduces daytime sleepiness and positively affects the quality of patients life.","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126617318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Myalovitska, S. R. Peleshok, T. V. Bernatska, Y. Nebor
The article describes a clinical case of development of ischemic stroke in the carotid and vertebrobasilar basin associated with nonspecific aortoarteritis (Takayasu disease). The diagnosis is confirmed by magnetic resonance imaging and transcerebral angiography. This case demonstrates the necessity for close cooperation of a neurologist and a rheumatologist in the management of patients with systemic vasculitis, in particular with nonspecific aortoarteritis.
{"title":"Clinical case of ischemic stroke development associated with nonspecific aortoarteritis (Takayasu disease)","authors":"O. Myalovitska, S. R. Peleshok, T. V. Bernatska, Y. Nebor","doi":"10.30978/UNJ2018-3-57","DOIUrl":"https://doi.org/10.30978/UNJ2018-3-57","url":null,"abstract":"The article describes a clinical case of development of ischemic stroke in the carotid and vertebrobasilar basin associated with nonspecific aortoarteritis (Takayasu disease). The diagnosis is confirmed by magnetic resonance imaging and transcerebral angiography. This case demonstrates the necessity for close cooperation of a neurologist and a rheumatologist in the management of patients with systemic vasculitis, in particular with nonspecific aortoarteritis.","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121530596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Double role of microglyia in pathogenesis of multiple sclerosis","authors":"N. I. Lysyanyi","doi":"10.30978/UNJ2018-3-5","DOIUrl":"https://doi.org/10.30978/UNJ2018-3-5","url":null,"abstract":"","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115581054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"European Board Examination in Neurology. Variants of questions with answers","authors":"V. Gryb, V. S. Botyev","doi":"10.30978/unj2018-3-73","DOIUrl":"https://doi.org/10.30978/unj2018-3-73","url":null,"abstract":"","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115719708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The usage of the scrining algorithm SVBI-pro in practical neurology","authors":"N. Nekrasova, I. Grygorova, V. Tretyak","doi":"10.30978/unj2018-3-68","DOIUrl":"https://doi.org/10.30978/unj2018-3-68","url":null,"abstract":"","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130110312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective — to study the clinical course and functional recovery of patients with various pathogenetic subtypes of ischemic stroke (IS) in small vessel disease (SVD). Methods and subjects. We performed a cohort prospective study of 117 patients with acute IS in SVD. 48 men and 69 women (mean age 67.7 ± 8.2 years) were included into study. Patients were divided into three groups based on the pathogenetic subtype of IS: atherothrombotic (AT, n = 66), cardioembolic (CE, n = 24) and lacunar (LI, n = 27). Inclusion criteria were: the first IS, history of arterial hypertension (AH), signs of SVD according to MRI. All patients underwent a comprehensive clinical, neurological, laboratory and instrumental examination. The diagnosis and the subtype of IS were verified by Doppler ultrasonography of head and neck vessels, Echo CG, ECG, and cerebral MRI. The degree of impairment of neurological functions was assessed on the 1st, 7th and 14th days after the hospitalization by NIHSS. On the 14th day, the level of daily life activity was assessed using the Bartel index (BI), and the degree of disability was estimated using the modified Rankine scale (mRS). Results. There was a difference in the signs of SVD in various pathogenetic subtypes of IS: significantly more white matter hyperintensity was found in patients with the AT subtype, whereas with the CE subtype, lacunae were observed more often (p < 0.01). It was revealed that SVD has more impact in AT and LI subtypes of IS. SVD has been shown to have different interdependence between stroke severity and functional recovery in various IS subtypes: the white matter hyperintensity and expansion of perivascular spaces on MRI relate to bigger stroke severity and worse functional recovery in AT subtype, whereas microhemorrhages and lacunas have greater effect in LI. Severity of stroke and functional status of CE subtype of IS do not corelate to SVD. Conclusions. In the presence of AH, signs of SVD can be detected in all pathogenetic subtypes of IS, regardless of the presence of other risk factors. Related to SVD pronounced neuroimaging changes develop at the 2nd stage of AH. Different neuroimaging signs of SVD are recorded with different frequency in AT, CE and LI subtypes of IS. Their presence mostly affects the course of AT and LI subtypes of IS. There is a relationship between the severity of stroke, functional recovery of patients with AT and LI subtypes of IS and neuroimaging signs of SVD, but its role in the development of IS and the recovery of patients with different subtypes of IS requires further study.
目的:探讨缺血性脑卒中(IS)不同病理亚型合并小血管病变(SVD)患者的临床病程及功能恢复情况。方法和对象。我们对117例SVD急性IS患者进行了队列前瞻性研究。男性48例，女性69例，平均年龄67.7±8.2岁。根据IS的发病亚型将患者分为3组:动脉粥样硬化血栓性(AT, n = 66)、心脏栓塞性(CE, n = 24)和腔隙性(LI, n = 27)。纳入标准为:首次IS、有动脉高血压史、MRI有SVD征象。所有患者均接受了全面的临床、神经、实验室和仪器检查。通过头颈部血管多普勒超声、超声心动图、心电图、脑MRI对IS的诊断和亚型进行验证。分别于住院后第1、7、14天采用NIHSS评估神经功能损害程度。第14天，使用Bartel指数(BI)评估日常生活活动水平，使用改良Rankine量表(mRS)评估残疾程度。结果。IS各病理亚型的SVD征象存在差异:AT亚型患者白质高信号明显增多，CE亚型患者白质高信号明显增多(p < 0.01)。结果表明SVD对IS AT和LI亚型的影响更大。在不同IS亚型中，SVD在卒中严重程度和功能恢复之间具有不同的相互依赖性:AT亚型中MRI上的白质高强度和血管周围空间扩张与卒中严重程度和功能恢复差相关，而LI亚型中微出血和腔隙的影响更大。脑卒中严重程度和IS CE亚型的功能状态与SVD无关。结论。在AH存在的情况下，无论是否存在其他危险因素，在IS的所有致病亚型中都可以检测到SVD的迹象。与SVD相关，AH第二阶段出现明显的神经影像学改变。在IS的AT、CE和LI亚型中，SVD的不同神经影像学征象记录频率不同。它们的存在主要影响IS AT和LI亚型的病程。脑卒中的严重程度、AT和LI亚型is患者的功能恢复与SVD的神经影像学征象存在一定的关系，但其在不同亚型is患者的发展和恢复中的作用有待进一步研究。
{"title":"Characteristics of the clinical course of ischemic stroke against the background small vessel disease","authors":"L. V. Panteleenko, V. Y. Krylova","doi":"10.30978/UNJ2018-3-26","DOIUrl":"https://doi.org/10.30978/UNJ2018-3-26","url":null,"abstract":"Objective — to study the clinical course and functional recovery of patients with various pathogenetic subtypes of ischemic stroke (IS) in small vessel disease (SVD). Methods and subjects. We performed a cohort prospective study of 117 patients with acute IS in SVD. 48 men and 69 women (mean age 67.7 ± 8.2 years) were included into study. Patients were divided into three groups based on the pathogenetic subtype of IS: atherothrombotic (AT, n = 66), cardioembolic (CE, n = 24) and lacunar (LI, n = 27). Inclusion criteria were: the first IS, history of arterial hypertension (AH), signs of SVD according to MRI. All patients underwent a comprehensive clinical, neurological, laboratory and instrumental examination. The diagnosis and the subtype of IS were verified by Doppler ultrasonography of head and neck vessels, Echo CG, ECG, and cerebral MRI. The degree of impairment of neurological functions was assessed on the 1st, 7th and 14th days after the hospitalization by NIHSS. On the 14th day, the level of daily life activity was assessed using the Bartel index (BI), and the degree of disability was estimated using the modified Rankine scale (mRS). Results. There was a difference in the signs of SVD in various pathogenetic subtypes of IS: significantly more white matter hyperintensity was found in patients with the AT subtype, whereas with the CE subtype, lacunae were observed more often (p < 0.01). It was revealed that SVD has more impact in AT and LI subtypes of IS. SVD has been shown to have different interdependence between stroke severity and functional recovery in various IS subtypes: the white matter hyperintensity and expansion of perivascular spaces on MRI relate to bigger stroke severity and worse functional recovery in AT subtype, whereas microhemorrhages and lacunas have greater effect in LI. Severity of stroke and functional status of CE subtype of IS do not corelate to SVD. Conclusions. In the presence of AH, signs of SVD can be detected in all pathogenetic subtypes of IS, regardless of the presence of other risk factors. Related to SVD pronounced neuroimaging changes develop at the 2nd stage of AH. Different neuroimaging signs of SVD are recorded with different frequency in AT, CE and LI subtypes of IS. Their presence mostly affects the course of AT and LI subtypes of IS. There is a relationship between the severity of stroke, functional recovery of patients with AT and LI subtypes of IS and neuroimaging signs of SVD, but its role in the development of IS and the recovery of patients with different subtypes of IS requires further study.","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"136 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131240107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this article, literature data and research findings obtained from the Experimental modeling laboratory of Institute of Genetic and Regenerative medicine are shown. This review testifies the effectiveness of using the in vivo and in vitro toxic cuprizone model for demyelination with the purpose of studying the pathogenic factors which include the immune, endocrine and oxidative stress factors associated with age, sex and strains of animals, as well as finding remyelinizing/neuroprotective remedies. The advantages of the cuprizone model for demyelination over other experimental models are also described. Using, as an example the effectiveness of our application of cytokines (leukemia inhibitory factor) and hormones (melatonin) with the remyelinating effects we show the promise of the in vitro demyelination cuprizone model for screening the remyelinating factors. The possibilities of using the experimental cuprizone model for studying other pathologies of the nervous system are justified.
{"title":"Possibilities and prospects of the application of the in vivo and in vitro toxic cuprizone model for demyelination in experimental and clinical neurology (literature review and own research results)","authors":"I. Labunets","doi":"10.30978/unz2018263","DOIUrl":"https://doi.org/10.30978/unz2018263","url":null,"abstract":"In this article, literature data and research findings obtained from the Experimental modeling laboratory of Institute of Genetic and Regenerative medicine are shown. This review testifies the effectiveness of using the in vivo and in vitro toxic cuprizone model for demyelination with the purpose of studying the pathogenic factors which include the immune, endocrine and oxidative stress factors associated with age, sex and strains of animals, as well as finding remyelinizing/neuroprotective remedies. The advantages of the cuprizone model for demyelination over other experimental models are also described. Using, as an example the effectiveness of our application of cytokines (leukemia inhibitory factor) and hormones (melatonin) with the remyelinating effects we show the promise of the in vitro demyelination cuprizone model for screening the remyelinating factors. The possibilities of using the experimental cuprizone model for studying other pathologies of the nervous system are justified.","PeriodicalId":296251,"journal":{"name":"Ukrainian Neurological Journal","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133637654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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