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Ethnobotany and Phytochemical Composition of Alchornea Cordifolia in Abia State Nigeria 尼日利亚阿比亚州堇菜的民族植物学和植物化学成分
Pub Date : 2024-04-22 DOI: 10.53811/ijtcmr.1332261
D. Enyiukwu, A. C. Amadıoha, I. Bassey
Alchornea cordifolia is one of the medicinal plants used in treatment of several medical challenges in Nigeria. The study was carried out to document the medicinal values of different parts of A. cordifolia in Ekebedi Oboro ancient Kingdom, and profile its bioactive constituents. The ethno-botanical survey involved oral interview of 81 randomly selected traditional medicine doctors and natives on medicinal values of A. cordifolia. The survey showed that A cordifolia is a major herb used in the treatment of various diseases in the ancient Kingdom and it is prescribed in different treatment regimens; coughs, bronchitis, post-partum bleeding, lacerations, wounds, vaginitis, diarrhea, sickle cell anaemia, venereal diseases including gonorhhea, and syphilis, and prostatitis. GC-MS fingerprinting was adopted to determine the bioactive constituents of methanol leaf extract of the plant. Phytochemical fingerprinting revealed the presence of several bioactive compounds as the major active ingredients of the plant. A total of 27 fatty acids and volatile hydrocarbons were detected in the leaf extract of the plant with 9, 12-Octadecadienoic acid (Z,Z)- methyl ester (18.42%), 9-Octadecanoic acid methyl ester (19.93%), Dodecanoic acid 1,2,3-propanetrieyl (15.87%) as most abundant ingredients. These phytochemical compounds of A. cordifolia possibly underscored its antimicrobial and therapeutic action and explains why natives use them in traditional medicine.
Alchornea cordifolia 是尼日利亚用于治疗多种医学难题的药用植物之一。本研究旨在记录 Ekebedi Oboro 古王国中不同部位的虫草属植物的药用价值,并分析其生物活性成分。在民族植物学调查中,随机抽取了 81 名传统医学医生和当地人,就 A. cordifolia 的药用价值进行了口头访谈。调查显示,A cordifolia 是古王国治疗各种疾病的主要草药,被用于不同的治疗方案:咳嗽、支气管炎、产后出血、撕裂伤、伤口、阴道炎、腹泻、镰状细胞性贫血、性病(包括淋病和梅毒)以及前列腺炎。采用气相色谱-质谱指纹图谱测定了该植物甲醇叶提取物中的生物活性成分。植物化学指纹图谱显示,该植物的主要活性成分中含有多种生物活性化合物。在该植物的叶提取物中总共检测到 27 种脂肪酸和挥发性碳氢化合物,其中含量最高的成分是 9,12-十八碳二烯酸(Z,Z)- 甲酯(18.42%)、9-十八烷酸甲酯(19.93%)、十二烷酸 1,2,3-丙三酯(15.87%)。A.cordifolia的这些植物化学物质可能强调了其抗菌和治疗作用,并解释了当地人为何将其用于传统医药。
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引用次数: 0
Knowledge, Attitudes, and Behaviors of Medical Residents towards Traditional and Complementary Medicine: A Cross-sectional Study 医学住院医师对传统医学和补充医学的认识、态度和行为:横断面研究
Pub Date : 2024-04-22 DOI: 10.53811/ijtcmr.1397656
İbrahim Bayram Alparslan, M. Sahin
Objective: This study aimed to evaluate the knowledge, attitudes, and behaviors of medical residents working at a faculty of medicine hospital about Traditional and Complementary Medicine (TCM). Material-Method: This is a cross-sectional study. The study was conducted with clinical science assistants working at the faculty of medicine between 15 July and 15 December 2021. A survey containing questions to determine the clinical and demographic characteristics of the participants and their knowledge, behavior, and attitudes toward TCM applications was applied to the participants. Results: A total of 261 medical residents participated. The average age was 29.4±2.6 years and 51.7% (n=135) were male. 82% of the participants were studying internal medicine sciences. The average length of time as a physician was found to be 4.4 years, and the average length of time as a physician in the total branch was 2.6 years. Cupping therapy was the most known method with 55.6%. The most frequently used method (19.2%) was phytotherapy; the most frequently recommended (16.5%) was phytotherapy; the most formally trained (4.2%), was cupping therapy; the most desired formal training (41%) was acupuncture; the most frequently declared method (11.9%) as another TCM method was diet. 36.4% of the participants found TCM useful. 82% thought that these methods should only be applied by trained physicians. Conclusion: It was determined that the level of TCM knowledge among assistant physicians was low. Although the majority of participants had a positive attitude towards TCM, they had low rates of application, implementation, and recommendation.
研究目的本研究旨在评估在医学院附属医院工作的住院医师对传统与补充医学(TCM)的认识、态度和行为。材料-方法:这是一项横断面研究。研究对象为 2021 年 7 月 15 日至 12 月 15 日期间在医学院工作的临床科学助理。对参与者进行了一项调查,其中包含一些问题,以确定参与者的临床和人口统计学特征以及他们对中医药应用的知识、行为和态度。调查结果显示共有 261 名住院医师参加了调查。平均年龄为(29.4±2.6)岁,51.7%(n=135)为男性。82%的参与者学习内科学。作为医生的平均年限为 4.4 年,作为总科医生的平均年限为 2.6 年。拔罐疗法是最为人所知的方法,占 55.6%。最常使用的方法(19.2%)是植物疗法;最常推荐的方法(16.5%)是植物疗法;接受过最正规培训的方法(4.2%)是拔罐疗法;最希望接受正规培训的方法(41%)是针灸;最常宣称的另一种中医方法(11.9%)是饮食疗法。36.4% 的参与者认为中医有用。82%的人认为这些方法只能由受过培训的医生使用。结论结果表明,助理医师的中医知识水平较低。虽然大多数参与者对中医持积极态度,但他们应用、实施和推荐中医的比例较低。
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引用次数: 0
Associations and predictors of psychological distress among students following disruption of academic activities by strikes embarked by university workers in Nigeria public universities 尼日利亚公立大学学生因大学工人罢工而中断学术活动后心理压力的关联和预测因素
Pub Date : 2024-04-18 DOI: 10.53811/ijtcmr.1354228
P. Ewah, Idoo Womboh, P. Awhen
Objective Psychological distress is experienced to be heightened among students during health distress and the disruption of academic activities by strikes. This study sought to determine the associating and predicting factors of anxiety and depression among university students following the disruption of academic activities by strikes. Material-Method This cross-sectional face-to-face and online study conveniently recruited a total of 317 students aged 15-51 years. The student's socio-demographic, socioeconomic, physical characteristics, and psychological distress were assessed using a structured questionnaire, Patient Health Questionnaire-9 (PHQ-9), and General Anxiety Disorder–7 (GAD-7). Data analysis consists of descriptive statistics, Pearson's Chi-square test, and Logistic regression, at a significant level of p
目的 在健康受到影响和学术活动受到罢工干扰时,学生的心理困扰会加剧。本研究旨在确定因罢工而中断学术活动的大学生焦虑和抑郁的相关因素和预测因素。材料-方法 本横断面研究采用面对面和在线的方式,共招募了 317 名 15-51 岁的学生。采用结构化问卷、患者健康问卷-9(PHQ-9)和一般焦虑症-7(GAD-7)对学生的社会人口、社会经济、身体特征和心理困扰进行了评估。数据分析包括描述性统计、Pearson's Chi-square 检验和 Logistic 回归,显著性水平为 P
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引用次数: 0
Application of a Chitosan-Based Hydrogel Dressing Containing Artemisia absinthium L. for the Burn Wounds: A Comprehensive In Vivo Study 含艾蒿的壳聚糖水凝胶敷料在烧伤创面中的应用:体内综合研究
Pub Date : 2024-04-16 DOI: 10.53811/ijtcmr.1440406
Meryem Aydın, Yunus Özcan, Sinem Kantarcioglu Coskun, Merve Alpay, Nuri Cenk Coşkun
Objective: Wormwood (Artemisia absinthium L.) is a valuable medicinal plant that has been used for the wound healing since ancient times. Hydrogel dressings are often preferred for wound care in treatment. In this study, the effects of chitosan-based hydrogel dressings containing wormwood were investigated in rats with burn wound model for the first time. Material-Method: Certain phenolic compounds in wormwood extracts were detected by LC-MS/MS and antioxidant activities were calculated using the DPPH. The antimicrobial activity of the dressings was tested using the disk diffusion method. Tissues taken from 48 female Sprague-Dawley rats were histopathologically examined at day 3rd and 21st. Skin tissue cytokine levels were measured using ELISA. All data obtained from histopathological examination and cytokine levels were statistically evaluated. Results: Fifteen phenolic compounds were quantitatively determined in wormwood extracts. The antioxidant activities of high-, medium-, and low-dose wormwood extracts were as 91,1% ± 0,054, 89,6% ± 0,012 and 84,1% ± 0,02, respectively. The hydrogel dressings did not show any antimicrobial activity against S. aureus (ATCC 29213) or P. aeruginosa (ATCC 27853). Granulation tissue formation, collagen increase, and regular scar appearance were higher in the all three wormwood groups. Wound contraction was completed and remodeling phase started at day 21st, especially in the high-dose wormwood treatment group. Tissue cytokine levels were determined in pg/ml in all groups. Conclusion: It was determined that A. absinthium L. can promote wound healing through various mechanisms of action and shows immunomodulatory effects, and is appropriate for use as a wound dressing in the form of a chitosan-based hydrogel.
目的:艾蒿(Artemisia absinthium L.)是一种珍贵的药用植物,自古以来就被用于伤口愈合。水凝胶敷料通常是治疗伤口护理的首选。本研究首次在烧伤模型大鼠身上研究了含有艾蒿的壳聚糖水凝胶敷料的效果。材料-方法:用 LC-MS/MS 检测艾草提取物中的某些酚类化合物,并用 DPPH 计算其抗氧化活性。敷料的抗菌活性采用盘扩散法进行测试。第 3 天和第 21 天,对 48 只雌性 Sprague-Dawley 大鼠的组织进行组织病理学检查。使用酶联免疫吸附法测定皮肤组织细胞因子水平。对从组织病理学检查和细胞因子水平中获得的所有数据进行统计评估。结果定量测定了艾草提取物中的 15 种酚类化合物。高、中、低剂量艾草提取物的抗氧化活性分别为 91.1% ± 0.054、89.6% ± 0.012 和 84.1% ± 0.02。水凝胶敷料对金黄色葡萄球菌(ATCC 29213)或绿脓杆菌(ATCC 27853)没有任何抗菌活性。三组艾草敷料的肉芽组织形成、胶原蛋白增加和疤痕外观规则程度都更高。伤口收缩在第 21 天完成,重塑阶段开始,尤其是在大剂量艾草治疗组。各组组织细胞因子水平的测定单位均为 pg/ml。结论确定苦艾草能通过各种作用机制促进伤口愈合,并具有免疫调节作用,适合以壳聚糖水凝胶的形式用作伤口敷料。
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引用次数: 0
Antibacterial, Phytochemical and Toxicological Activities of Garcinia kola Extracts against Multidrug Resistant Clinical Bacteria 加西考拉提取物对耐多药临床细菌的抗菌、植物化学和毒理学活性
Pub Date : 2024-04-05 DOI: 10.53811/ijtcmr.1407843
Kolawole Oyetunji, Blessing Nwadike
Objective: The rise in multiple antibiotic resistant microorganisms has led to a decline in the efficacy of many antibiotics, prompting the investigation of alternative solutions such as medicinal plants. To tackle this concerning issue, this study was undertaken to evaluate the phytochemical composition, antibacterial activity, and toxicological characteristics of Garcinia kola extracts against multidrug-resistant bacteria commonly found in clinical settings. Material-Method: The cold maceration technique was employed to extract the root and leaf of Garcinia kola using water and methanol. The extracts were then subjected to phytochemical screening. To evaluate the extracts' potential to inhibit bacterial growth, five multidrug-resistant isolates were utilized in this study. Agar well assay was used to determine the zones of inhibition. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) were determined using the broth macro dilution technique. Additionally, Brine shrimp lethality assay was conducted to determine the lethal concentration (LC50) of the extracts. The extracts were also combined for synergism. Results: The investigation found that the root extract in methanol had the highest yield at 25.58%. All four extracts contained ten out of the fourteen tested phytochemicals. The methanol leaf and root extracts exhibited the highest and lowest inhibition zones of 20mm and 9mm against Staphylococcus aureus, respectively. The MIC values ranged from 250 to 600 mg/ml, indicating broad-spectrum antibacterial activity. The cytotoxicity test showed a range of 33.03 to 126.3µg/mL for the aqueous and methanol extracts. Conclusion: Although Garcinia kola shows potential as a source of antibacterial compounds, caution should be exercised due to its toxic effects.
目的:多种抗生素耐药微生物的增加导致许多抗生素的疗效下降,促使人们研究药用植物等替代解决方案。为了解决这一令人担忧的问题,本研究对植物化学成分、抗菌活性和加西考拉提取物的毒理学特征进行了评估,以对抗临床环境中常见的多重耐药菌。材料-方法:采用冷浸渍技术,用水和甲醇提取葛根和叶。然后对提取物进行植物化学筛选。为评估萃取物抑制细菌生长的潜力,本研究使用了五种耐多种药物的分离菌株。琼脂井试验用于确定抑制区。最小抑菌浓度(MIC)和最小杀菌浓度(MBC)则采用肉汤宏观稀释法测定。此外,还进行了盐水虾致死试验,以确定提取物的致死浓度(LC50)。还对提取物进行了组合,以确定其协同作用。结果调查发现,甲醇中的根提取物收率最高,为 25.58%。所有四种提取物都含有 14 种测试植物化学物质中的 10 种。甲醇叶提取物和根提取物对金黄色葡萄球菌的最高和最低抑菌区分别为 20 毫米和 9 毫米。MIC 值介于 250 至 600 mg/ml 之间,表明其具有广谱抗菌活性。细胞毒性测试表明,水提取物和甲醇提取物的细胞毒性范围在 33.03 至 126.3µg/mL 之间。结论尽管加西考拉具有作为抗菌化合物来源的潜力,但由于其毒性作用,应谨慎使用。
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引用次数: 0
Investigation of Attitudes Towards Complementary Alternative Medicine in Young Adulthood 调查成年青年对补充替代医学的态度
Pub Date : 2024-04-01 DOI: 10.53811/ijtcmr.1423626
Merve Yazar, Berna Bayir
Objective: This study was conducted to determine the attitudes of individuals aged 18-24 towards complementary alternative medicine. Material-Method: The sample of the cross-sectional study, which is one of the analytical research types, consisted of 178 individuals between the ages of 18-24, at least primary education level, having technological devices and able to use internet networks. Descriptive statistics, independent groups t test, ANOVA, Mann Whitney U, Kruskal Wallis, Tukey tests and regression analysis were used in the evaluation of the data. The significance level was taken as 0.05 in the interpretation of the results. Results: In the study, it was found that those who had a large family type, who thought that complementary or alternative medicine practices were beneficial, who recommended these practices to their close environment or friends, and who found complementary medicine practices more beneficial than the treatments applied in health institutions positively affected the scale mean scores (p
研究目的本研究旨在确定 18-24 岁人群对补充替代医学的态度。材料-方法:横断面研究是分析研究类型之一,样本包括 178 名年龄在 18-24 岁之间、至少受过初等教育、拥有技术设备并能使用互联网络的人。数据评估采用了描述性统计、独立组 t 检验、方差分析、曼-惠特尼 U 检验、Kruskal Wallis 检验、Tukey 检验和回归分析。在解释结果时,显著性水平为 0.05。结果研究发现,家庭人口多、认为补充或替代医学实践有益、向周围环境或朋友推荐补充或替代医学实践、认为补充医学实践比医疗机构的治疗更有益的人,对量表平均分有积极影响(P<0.05)。
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引用次数: 0
Information, Attitudes and Opinions of Physicians on Cups Treatment 医生对杯子治疗的信息、态度和观点
Pub Date : 2023-11-13 DOI: 10.53811/ijtcmr.1302952
Mustafa Özcan, Ali Vasfi Ağlarci
Objective: The aim of this study is to determine the knowledge, attitudes and thoughts of physicians about complementary medicine and cupping therapy in particular. Material-Method: Between October 1, 2018 and December 10, 2018, a questionnaire consisting of 27 questions was applied face-to-face to 435 physicians working in various health institutions in Ankara and who agreed to participate in the survey voluntarily. Chi-square analysis and logistic regression analysis methods were used in the evaluation of the data. The significance level was taken as 0.05 in the interpretation of the results. Results: The person's liking to practice medicine, having sufficient knowledge about traditional medicine, receiving training on traditional medicine, practicing traditional medicine, having him and his relatives practice traditional medicine, having positive and negative knowledge and experience about cupping, are effective in welcoming cupping practice positively (p
研究目的本研究旨在了解医生对补充医学,特别是拔罐疗法的认识、态度和想法。 材料-方法:2018 年 10 月 1 日至 2018 年 12 月 10 日期间,对 435 名在安卡拉各医疗机构工作并同意自愿参与调查的医生进行了面对面问卷调查,问卷包含 27 个问题。数据评估采用了卡方分析和逻辑回归分析方法。结果解释的显著性水平为 0.05。 结果喜欢行医、对传统医学有足够的了解、接受过传统医学培训、练习过传统医学、他和他的亲戚练习过传统医学、对拔罐有正面和负面的了解和经验,这些因素对拔罐练习的正面欢迎程度有效(P<0.05)。
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引用次数: 0
The Effects of Early Mobilization on Pain and Quality of Recovery in Patients Undergoing Laparoscopic Cholecystectomy Surgery: 早期活动对腹腔镜胆囊切除术患者疼痛和恢复质量的影响
Pub Date : 2023-11-07 DOI: 10.53811/ijtcmr.1342768
İbrahim Okcul, Semra Erdağı Oral
Objective: This study was conducted to determine the effects of early mobilization on pain and quality of recovery in patients undergoing laparoscopic cholecystectomy. Materials and methods: Pretest-posttest experimental design with control group. This study was carried out at the General Surgery Inpatient Clinic of a state hospital between April 2021 and January 2022. A total of 90 patients were included in the study. Starting with two hours after surgery, the patients in the experimental group were mobilized at least 6 times in 24 hours. A “Patient Description Form”, the “Visual Analog Scale for Pain”, and the “Quality of Recovery-40 Questionnaire” were used to collect data. Results: The introductory and medical characteristics of the patients in the intervention and control groups were similar. There was no significant difference between the pain and recovery quality mean scores of the patients in the two groups at the 2nd postoperative hour. The mean pain scores of the patients in the intervention group at the 24th hour and on the 15th day after surgery were found to be significantly lower than the scores of those in the control group. It was found that the mean recovery quality scores of the patients in the intervention group at the 24th hour and on the 15th day after surgery were also higher than those of the patients in the control group. Conclusions: It was determined that early mobilization reduced the level of pain and increased the quality of recovery in laparoscopic cholecystectomy patients.
研究目的本研究旨在确定早期活动对腹腔镜胆囊切除术患者疼痛和恢复质量的影响。 材料和方法:前测-后测实验设计,对照组。本研究于 2021 年 4 月至 2022 年 1 月期间在一家国立医院的普外科住院门诊进行。共有 90 名患者参与研究。从术后两小时开始,实验组患者在 24 小时内至少进行了 6 次移动。采用 "患者描述表"、"疼痛视觉模拟量表 "和 "康复质量-40 问卷 "收集数据。 结果干预组和对照组患者的自我介绍和医疗特征相似。两组患者在术后第 2 小时的疼痛和恢复质量平均得分无明显差异。干预组患者在术后第 24 小时和术后第 15 天的平均疼痛评分明显低于对照组。研究发现,干预组患者在术后第 24 小时和术后第 15 天的平均恢复质量评分也高于对照组患者。 结论研究结果表明,早期活动可减轻腹腔镜胆囊切除术患者的疼痛程度并提高其恢复质量。
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引用次数: 0
Immediate Effect of Non-Elastic Taping on Gait Balance in Stroke Patients: Randomized Controlled Trial 非弹性绑带对中风患者步态平衡的立竿见影效果:随机对照试验
Pub Date : 2023-10-31 DOI: 10.53811/ijtcmr.1344335
Beyzanur DİKMEN HOŞBAŞ, Mevlüt Oluk, Berna Karamancioğlu, İsmail İşiker, Deniz Demi̇rci̇
Objective: After a stroke, most patients have poor ankle control and difficulty walking. Considering that proper foot placement will provide a more balanced and controlled gait, the aim of this study was to investigate the immediate effect of non-elastic ankle taping providing eversion support on gait balance in stroke patients. Material-Method: The study included 30 stroke patients. Participants were randomly assigned to two groups: intervention group (n=15) and the control group (n=15). The control group received 45 min of conventional physiotherapy. The intervention group received 45 min of conventional physiotherapy after nonelastic taping, which provides eversion support. The gait balance of both groups was evaluated using the Dynamic Gait Index before and after treatment. Results: A significant difference was found in the Dynamic Gait Index total score of the intervention and control groups before and after treatment (p
目的:中风后,大多数患者的踝关节控制能力较差,行走困难。考虑到正确的足部位置可使步态更加平衡和可控,本研究旨在探讨提供外翻支持的非弹性踝关节绑带对中风患者步态平衡的直接影响。 材料-方法 研究对象包括 30 名中风患者。参与者被随机分配到两组:干预组(15 人)和对照组(15 人)。对照组接受 45 分钟的常规物理治疗。干预组在接受45分钟的常规物理治疗后,再进行非弹性绑带治疗,非弹性绑带可提供外翻支持。在治疗前后,使用动态步态指数对两组患者的步态平衡进行评估。 结果显示 干预组和对照组的动态步态指数总分在治疗前后有明显差异(p
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引用次数: 0
Immediate Effects of Cervical Mobilization on Acoustic Properties and Performance in Voice Training Students 颈椎活动对嗓音训练学生声学特性和表现的直接影响
Pub Date : 2023-10-16 DOI: 10.53811/ijtcmr.1345954
İ̇smail Ceylan, Satı Doğanyiğit, Anıl Özüdoğru
Objective: The aim of this study was investigation of immediate effects of cervical mobilization on acoustic properties and performance in voice training students. Material-Method: The research was conducted on 15 female volunteer students. Acoustic properties of the voice, performance and neck mobility were evaluated. Cervical mobilization was performed by an experienced physiotherapist. Then the assessments were repeated. Results: There was a significant change in cervical mobilization and performance after mobilization, no significant difference was found in the acoustic properties of the voice. Conclusion: It was observed that a single session of cervical mobilization positively affected performance and cervical mobility.
研究目的本研究旨在调查颈椎活动对嗓音训练学生的声学特性和表现的直接影响。 材料-方法研究对象为 15 名志愿女学生。对嗓音的声学特性、表现和颈部活动度进行了评估。由一名经验丰富的物理治疗师进行颈部活动。然后重复评估。 结果显示颈椎活动度和活动后的表现有明显变化,但嗓音的声学特性没有发现明显差异。 结论通过观察发现,单次颈椎活动对患者的表现和颈椎活动度有积极影响。
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引用次数: 0
期刊
International Journal of Traditional and Complementary Medicine Research
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