Pub Date : 2025-12-01DOI: 10.1016/j.ijcrp.2025.200498
Muzamil Akhtar , Hanzala Ahmed Farooqi , Rayyan Nabi , Javed Iqbal , Sabahat Ul Ain Munir Abbasi , Muhammad Rashid , Syed Khurram Mushtaq Gardezi , David P. Ripley , Raheel Ahmed
{"title":"Corrigendum to ‘Trends in mortality due to ischemic heart diseases among patients with Alzheimer's disease in the United States from 1999 to 2020’ [Int J Cardiol Cardiovasc Risk Prev. 2025 Mar 7;25:200390]","authors":"Muzamil Akhtar , Hanzala Ahmed Farooqi , Rayyan Nabi , Javed Iqbal , Sabahat Ul Ain Munir Abbasi , Muhammad Rashid , Syed Khurram Mushtaq Gardezi , David P. Ripley , Raheel Ahmed","doi":"10.1016/j.ijcrp.2025.200498","DOIUrl":"10.1016/j.ijcrp.2025.200498","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"27 ","pages":"Article 200498"},"PeriodicalIF":2.1,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145747327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1016/j.ijcrp.2025.200550
Elena-Mihaela Cordeanu , Emma Morisot , François Bronner , Eric Prinz , Dominique Stephan
Background
Resistant hypertension (RH) remains a major therapeutic challenge, affecting 12–18 % of treated hypertensive patients and associated with increased cardiovascular risk. Renal denervation (RDN) has emerged as a promising therapeutic option following initially mixed results.
Objective
This review analyzes the evolution of RH management, from its definition to new therapeutic perspectives offered by RDN, based on recent international guidelines (ESH 2023, ESC 2024, ACC/AHA 2025).
Methods
Critical analysis of pivotal clinical trials, recent meta-analyses, and international registries evaluating the efficacy and safety of RDN in RH.
Results
Recent trials (SPYRAL HTN-ON/OFF MED, RADIANCE-HTN TRIO) demonstrate moderate but significant efficacy of RDN, with systolic blood pressure reductions ranging from 3.9 to 18.7 mmHg depending on populations. Technological advances (multi-electrode catheters, distal branch targeting) improve outcomes. The safety profile appears favorable with low complication rates.
Conclusions
RDN represents an emerging therapeutic option for RH, now recommended by European societies for specific indications. Rigorous patient selection and performance in experienced centers remain essential.
{"title":"From resistant hypertension to renal denervation: an emerging therapeutic approach in light of new international guidelines","authors":"Elena-Mihaela Cordeanu , Emma Morisot , François Bronner , Eric Prinz , Dominique Stephan","doi":"10.1016/j.ijcrp.2025.200550","DOIUrl":"10.1016/j.ijcrp.2025.200550","url":null,"abstract":"<div><h3>Background</h3><div>Resistant hypertension (RH) remains a major therapeutic challenge, affecting 12–18 % of treated hypertensive patients and associated with increased cardiovascular risk. Renal denervation (RDN) has emerged as a promising therapeutic option following initially mixed results.</div></div><div><h3>Objective</h3><div>This review analyzes the evolution of RH management, from its definition to new therapeutic perspectives offered by RDN, based on recent international guidelines (ESH 2023, ESC 2024, ACC/AHA 2025).</div></div><div><h3>Methods</h3><div>Critical analysis of pivotal clinical trials, recent meta-analyses, and international registries evaluating the efficacy and safety of RDN in RH.</div></div><div><h3>Results</h3><div>Recent trials (SPYRAL HTN-ON/OFF MED, RADIANCE-HTN TRIO) demonstrate moderate but significant efficacy of RDN, with systolic blood pressure reductions ranging from 3.9 to 18.7 mmHg depending on populations. Technological advances (multi-electrode catheters, distal branch targeting) improve outcomes. The safety profile appears favorable with low complication rates.</div></div><div><h3>Conclusions</h3><div>RDN represents an emerging therapeutic option for RH, now recommended by European societies for specific indications. Rigorous patient selection and performance in experienced centers remain essential.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"27 ","pages":"Article 200550"},"PeriodicalIF":2.1,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145576289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-17DOI: 10.1016/j.ijcrp.2025.200548
Xiaoying Ren , Mengge Yang , Juan Tian, Xiaona Chang, Guang Wang, Jia Liu
Background
Body mass index (BMI) variability is considered to be associated with an increased risk of various diseases. However, the association between long-term BMI variability and cardiometabolic multimorbidity (CMM) remains elusive, especially in middle-aged and older adults. This study aimed to explore their relationship in two prospective cohorts.
Methods
Data were analyzed from the UK Biobank and the China Health and Retirement Longitudinal Study (CHARLS). CMM was defined as the coexistence of two or three cardiometabolic diseases, including diabetes mellitus, coronary heart disease, and stroke. BMI measurements from three visits were utilized to assess BMI variability. Cox regression analysis was employed to estimate the relationship between BMI variability and CMM.
Results
The incidence of CMM increased across increasing tertiles of BMI variability, particularly in overweight and obese individuals (all P for trend <0.05). This trend was absent in lean subgroups. In the UK Biobank, among participants who were overweight or obese at baseline (BMI ≥25 kg/m2), those in the highest tertile of BMI variability exhibited a higher burden of CMM compared to those in the lowest tertile (HR = 2.97, 95 %CI 1.98–4.48, P < 0.001). A similar association was observed in CHARLS among individuals overweight or obese at baseline (BMI ≥24 kg/m2) (HR = 1.56, 95 %CI 1.09–2.35, P = 0.017). No significant association was found between BMI variability and CMM risk in participants with normal baseline BMI.
Conclusions
Higher BMI variability was significantly associated with an elevated risk of CMM in individuals with pre-existing overweight or obesity.
背景：体重指数（BMI）的可变性被认为与各种疾病的风险增加有关。然而，长期BMI变异性与心脏代谢多病（CMM）之间的关系仍然难以捉摸，特别是在中老年人中。本研究旨在通过两个前瞻性队列探讨两者之间的关系。方法分析来自英国生物银行和中国健康与退休纵向研究（CHARLS）的数据。CMM被定义为同时存在两种或三种心脏代谢疾病，包括糖尿病、冠心病和中风。使用三次就诊的BMI测量来评估BMI变异性。采用Cox回归分析估计BMI变异性与CMM之间的关系。结果CMM的发病率随着BMI变异性的增加而增加，特别是在超重和肥胖个体中（趋势均为P；0.05）。这种趋势在瘦肉亚组中不存在。在UK Biobank中，在基线时超重或肥胖的参与者（BMI≥25 kg/m2）中，BMI变异性最高分位数的参与者比最低分位数的参与者表现出更高的CMM负担（HR = 2.97, 95% CI 1.98-4.48, P < 0.001）。基线时超重或肥胖个体（BMI≥24 kg/m2）的CHARLS也存在类似的关联（HR = 1.56, 95% CI 1.09-2.35, P = 0.017）。在基线BMI正常的参与者中，BMI变异性与CMM风险之间未发现显著关联。结论较高的BMI变异性与既往超重或肥胖个体CMM风险升高显著相关。
{"title":"Long-term body mass index variability and the risk of cardiometabolic multimorbidity in middle-aged and older adults: Insights from two prospective cohorts","authors":"Xiaoying Ren , Mengge Yang , Juan Tian, Xiaona Chang, Guang Wang, Jia Liu","doi":"10.1016/j.ijcrp.2025.200548","DOIUrl":"10.1016/j.ijcrp.2025.200548","url":null,"abstract":"<div><h3>Background</h3><div>Body mass index (BMI) variability is considered to be associated with an increased risk of various diseases. However, the association between long-term BMI variability and cardiometabolic multimorbidity (CMM) remains elusive, especially in middle-aged and older adults. This study aimed to explore their relationship in two prospective cohorts.</div></div><div><h3>Methods</h3><div>Data were analyzed from the UK Biobank and the China Health and Retirement Longitudinal Study (CHARLS). CMM was defined as the coexistence of two or three cardiometabolic diseases, including diabetes mellitus, coronary heart disease, and stroke. BMI measurements from three visits were utilized to assess BMI variability. Cox regression analysis was employed to estimate the relationship between BMI variability and CMM.</div></div><div><h3>Results</h3><div>The incidence of CMM increased across increasing tertiles of BMI variability, particularly in overweight and obese individuals (all <em>P</em> for trend <0.05). This trend was absent in lean subgroups. In the UK Biobank, among participants who were overweight or obese at baseline (BMI ≥25 kg/m<sup>2</sup>), those in the highest tertile of BMI variability exhibited a higher burden of CMM compared to those in the lowest tertile (HR = 2.97, 95 %CI 1.98–4.48, <em>P</em> < 0.001). A similar association was observed in CHARLS among individuals overweight or obese at baseline (BMI ≥24 kg/m<sup>2</sup>) (HR = 1.56, 95 %CI 1.09–2.35, <em>P</em> = 0.017). No significant association was found between BMI variability and CMM risk in participants with normal baseline BMI.</div></div><div><h3>Conclusions</h3><div>Higher BMI variability was significantly associated with an elevated risk of CMM in individuals with pre-existing overweight or obesity.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"27 ","pages":"Article 200548"},"PeriodicalIF":2.1,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145576234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1016/j.ijcrp.2025.200545
Enze Li , Le Zhou , Liu He, Song Zuo, Song-Nan Li, Xiao-Xia Liu, Cai-Hua Sang, Jian-Zeng Dong, Xue-Yuan Guo, Changsheng Ma
Background
Anxiety and depression are established risk factors for cardiovascular disease (CVD); impacts of these conditions on cardiovascular outcomes across different levels of cardiovascular health (CVH), measured by Life's Essential 8 (LE8) scores, remain unclear.
Methods and results
We analyzed 290,778 UK Biobank participants (mean age 56.5, 56.1 % male) without prior CVD. CVH was assessed using the LE8 score. Mental health status (healthy, anxiety only, depression only, or comorbid anxiety and depression) was determined through PHQ-4 items and ICD-10 codes (F32-F33 for depression, F40-F41 for anxiety). Cardiovascular outcomes were defined as a composite of coronary heart disease (CHD), heart failure (HF), and stroke. Cox proportional hazards models were adjusted for confounders and stratified by LE8 score (<50 [poor CVH] vs. ≥50 [intermediate-optimal]). Compared to the mentally healthy group, participants with comorbid anxiety and depression had the highest overall cardiovascular risk (adjusted HR 1.85 [95 % CI 1.74–1.97]). The impact of mental health status varied according to baseline LE8 scores. Among those with LE8 <50, isolated anxiety (adjusted HR 1.23 [1.09–1.40]), depression (adjusted HR 1.34 [1.22–1.47]), as well as comorbid anxiety and depression (adjusted HR 1.46 [1.31–1.64]) were all associated with increased cardiovascular risk. In the LE8 ≥50 group, isolated anxiety (adjusted HR 1.39 [1.30–1.48]), isolated depression (adjusted HR 1.52 [1.43–1.60]), and comorbid anxiety and depression (adjusted HR 1.78 [1.66–1.90]) were all associated with increased risk.
Conclusions
Mental health independently affects cardiovascular risk, modified by baseline CVH. Mental health emerge as a relative risk predictor among individuals with CVH (LE8 ≥ 50).
背景焦虑和抑郁是心血管疾病（CVD）的危险因素；这些条件对不同心血管健康水平（CVH）的心血管结果的影响（以生命基本8 （LE8）评分衡量）仍不清楚。方法和结果我们分析了290,778名UK Biobank参与者（平均年龄56.5岁，56.1%为男性）既往无心血管疾病。CVH采用LE8评分进行评估。通过PHQ-4项目和ICD-10代码（抑郁为F32-F33，焦虑为F40-F41）确定心理健康状况（健康、仅焦虑、仅抑郁或共患焦虑和抑郁）。心血管结局被定义为冠心病（CHD）、心力衰竭（HF）和中风的综合结果。对Cox比例风险模型进行混杂因素调整，并按LE8评分分层（<；50[差CVH] vs.≥50[中优]）。与心理健康组相比，患有焦虑和抑郁共病的参与者总体心血管风险最高（调整后HR 1.85 [95% CI 1.74-1.97]）。心理健康状况的影响因基线LE8得分而异。在LE8 <；50的患者中，孤立性焦虑（调整后的HR为1.23[1.09-1.40]）、抑郁（调整后的HR为1.34[1.22-1.47]）以及共病性焦虑和抑郁（调整后的HR为1.46[1.31-1.64]）均与心血管风险增加相关。在LE8≥50组中，孤立性焦虑（调整后的HR为1.39[1.30-1.48]）、孤立性抑郁（调整后的HR为1.52[1.43-1.60]）、焦虑和抑郁共病（调整后的HR为1.78[1.66-1.90]）均与风险增加相关。结论心理健康独立影响心血管风险，并受基线CVH影响。精神健康是CVH患者（LE8≥50）的相对风险预测因子。
{"title":"Mental health status and cardiovascular outcomes across Life's Essential 8 categories","authors":"Enze Li , Le Zhou , Liu He, Song Zuo, Song-Nan Li, Xiao-Xia Liu, Cai-Hua Sang, Jian-Zeng Dong, Xue-Yuan Guo, Changsheng Ma","doi":"10.1016/j.ijcrp.2025.200545","DOIUrl":"10.1016/j.ijcrp.2025.200545","url":null,"abstract":"<div><h3>Background</h3><div>Anxiety and depression are established risk factors for cardiovascular disease (CVD); impacts of these conditions on cardiovascular outcomes across different levels of cardiovascular health (CVH), measured by Life's Essential 8 (LE8) scores, remain unclear.</div></div><div><h3>Methods and results</h3><div>We analyzed 290,778 UK Biobank participants (mean age 56.5, 56.1 % male) without prior CVD. CVH was assessed using the LE8 score. Mental health status (healthy, anxiety only, depression only, or comorbid anxiety and depression) was determined through PHQ-4 items and ICD-10 codes (F32-F33 for depression, F40-F41 for anxiety). Cardiovascular outcomes were defined as a composite of coronary heart disease (CHD), heart failure (HF), and stroke. Cox proportional hazards models were adjusted for confounders and stratified by LE8 score (<50 [poor CVH] vs. ≥50 [intermediate-optimal]). Compared to the mentally healthy group, participants with comorbid anxiety and depression had the highest overall cardiovascular risk (adjusted HR 1.85 [95 % CI 1.74–1.97]). The impact of mental health status varied according to baseline LE8 scores. Among those with LE8 <50, isolated anxiety (adjusted HR 1.23 [1.09–1.40]), depression (adjusted HR 1.34 [1.22–1.47]), as well as comorbid anxiety and depression (adjusted HR 1.46 [1.31–1.64]) were all associated with increased cardiovascular risk. In the LE8 ≥50 group, isolated anxiety (adjusted HR 1.39 [1.30–1.48]), isolated depression (adjusted HR 1.52 [1.43–1.60]), and comorbid anxiety and depression (adjusted HR 1.78 [1.66–1.90]) were all associated with increased risk.</div></div><div><h3>Conclusions</h3><div>Mental health independently affects cardiovascular risk, modified by baseline CVH. Mental health emerge as a relative risk predictor among individuals with CVH (LE8 ≥ 50).</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"27 ","pages":"Article 200545"},"PeriodicalIF":2.1,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145576232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-14DOI: 10.1016/j.ijcrp.2025.200547
Abdalhakim Shubietah , Mohamed S. Elgendy , Abubakar Nazir , Ahmed Ahmed , Ameer Awashra , Mustafa Alkhawam , Sarah Saife , Hamza A. Abdul-Hafez , Mohamed Saad Rakab , Mohammed AbuBaha , Mohammed Tareq Mutar , Ahmed Emara
Background
The population-level burden and inequities of aortic dissection (AD) mortality in the United States remain incompletely defined, and contemporary, data-driven forecasts are scarce.
Methods
Using the CDC WONDER Death database (1968–2023), AD deaths were identified by ICD codes (ICD-8/9: 441.0; ICD-10: I71.0). Age-adjusted mortality rates (AAMRs) per 100,000 were stratified by sex, race, age, and Census region. Temporal trends were assessed using Joinpoint regression to estimate annual percent change (APC) and average APC (AAPC). Forecasts through 2033 employed a Bi-GRU model.
Results
We analyzed 175,930 AD-related deaths. Overall, the national AAMR declined by 43 % across 1968–2023 (AAPC −1.10 %, 95 % CI −1.19 to −1.00) but showed a recent upturn (APC +2.00 %, 95 % CI 1.53–2.57). Mortality remained higher in men than women and in Black than White individuals, increased steeply with age, and varied geographically. Bi-GRU forecasts project a modest national decline in AAMR from 1.62 to 1.47 by 2033, with persistent sex (men 1.91 vs women 1.12) and racial (Black 2.32 vs White 1.35) gaps; a slight increase is confined to the South (1.62 → 1.64), while rates in adults ≥85 years improve (10.26 → 9.70).
Conclusions
While U.S. AD mortality has nearly halved over five decades, recent increases and persistent demographic and regional disparities highlight uneven progress. Forecasts to 2033 suggest modest overall declines with persistent sex and racial gaps; targeted hypertension control and regional access to high-volume aortic centers remain priorities.
{"title":"Aortic dissection mortality in the United States, 1968–2023: Trends, disparities, and deep learning forecasts","authors":"Abdalhakim Shubietah , Mohamed S. Elgendy , Abubakar Nazir , Ahmed Ahmed , Ameer Awashra , Mustafa Alkhawam , Sarah Saife , Hamza A. Abdul-Hafez , Mohamed Saad Rakab , Mohammed AbuBaha , Mohammed Tareq Mutar , Ahmed Emara","doi":"10.1016/j.ijcrp.2025.200547","DOIUrl":"10.1016/j.ijcrp.2025.200547","url":null,"abstract":"<div><h3>Background</h3><div>The population-level burden and inequities of aortic dissection (AD) mortality in the United States remain incompletely defined, and contemporary, data-driven forecasts are scarce.</div></div><div><h3>Methods</h3><div>Using the CDC WONDER Death database (1968–2023), AD deaths were identified by ICD codes (ICD-8/9: 441.0; ICD-10: I71.0). Age-adjusted mortality rates (AAMRs) per 100,000 were stratified by sex, race, age, and Census region. Temporal trends were assessed using Joinpoint regression to estimate annual percent change (APC) and average APC (AAPC). Forecasts through 2033 employed a Bi-GRU model.</div></div><div><h3>Results</h3><div>We analyzed 175,930 AD-related deaths. Overall, the national AAMR declined by 43 % across 1968–2023 (AAPC −1.10 %, 95 % CI −1.19 to −1.00) but showed a recent upturn (APC +2.00 %, 95 % CI 1.53–2.57). Mortality remained higher in men than women and in Black than White individuals, increased steeply with age, and varied geographically. Bi-GRU forecasts project a modest national decline in AAMR from 1.62 to 1.47 by 2033, with persistent sex (men 1.91 vs women 1.12) and racial (Black 2.32 vs White 1.35) gaps; a slight increase is confined to the South (1.62 → 1.64), while rates in adults ≥85 years improve (10.26 → 9.70).</div></div><div><h3>Conclusions</h3><div>While U.S. AD mortality has nearly halved over five decades, recent increases and persistent demographic and regional disparities highlight uneven progress. Forecasts to 2033 suggest modest overall declines with persistent sex and racial gaps; targeted hypertension control and regional access to high-volume aortic centers remain priorities.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"27 ","pages":"Article 200547"},"PeriodicalIF":2.1,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145576233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-12DOI: 10.1016/j.ijcrp.2025.200543
Shuo Yang , Hong Shen , Yukun You , Zhenyue Fu , Shuaijie Guo , Yifan Zhang , Qincheng Liu , Ying Yang , Ye Li , Ji Qin , Ping Liu
Background
Atherosclerosis (AS) is driven by inflammatory and metabolic dysregulation. Carotid atherosclerosis (CA), assessable by ultrasonographic carotid intima–media thickness (cIMT) and plaque, provides a noninvasive window into AS. Adipose tissue–derived adipokines are involved in AS.
Aim
We conducted a phenotype-specific systematic review and meta-analysis of observational studies to quantify associations between circulating adipokines and CA.
Methods
Following a preregistered protocol, PubMed, Embase, and Web of Science were searched. Adults with ultrasound-defined CA (increased cIMT and/or carotid plaque) and controls were included. Mean and standard deviation (SD) of circulating adipokines were extracted and converted to standardized mean difference (SMD) for pooled analysis.
Results
Nineteen studies (n = 5860; Asia/Europe/Americas; 8 cross-sectional, 8 case-control, 3 cohort) were included for quantitative analysis. In the increased cIMT phenotype, adiponectin was lower in CA [SMD = −0.72 (−1.00, −0.44), P < 0.05], whereas in the plaque phenotype it was higher [SMD = 0.29 (0.11, 0.47), P < 0.05]. Leptin was higher in CA, reaching significance in the plaque phenotype [SMD = 0.70 (0.13, 1.28), P = 0.02]. Omentin was consistently lower in CA across phenotypes [SMD = −1.43 (−2.20, −0.66), P < 0.001]. Sensitivity analysis supported robustness for adiponectin (stronger effects after excluding healthy cohorts), and publication-bias assessment was feasible only for adiponectin and were negative.
Conclusions
This study indicated that circulating adipokine levels can serve as phenotype-specific biomarkers in CA.
动脉粥样硬化（AS）是由炎症和代谢失调驱动的。颈动脉粥样硬化（CA），通过超声颈动脉内膜-中膜厚度（cIMT）和斑块来评估，为观察AS提供了一个无创窗口。脂肪组织来源的脂肪因子参与AS。我们对观察性研究进行了表型特异性的系统回顾和荟萃分析，以量化循环脂肪因子与ca之间的关系。方法按照预先注册的方案，检索PubMed， Embase和Web of Science。包括超声诊断的CA （cIMT增加和/或颈动脉斑块）和对照组的成年人。提取循环脂肪因子的均值和标准差（SD）并转换为标准化平均差（SMD）进行合并分析。结果纳入19项研究（n = 5860，亚洲/欧洲/美洲，横断面8项，病例对照8项，队列3项）进行定量分析。在cIMT表型增加的情况下，CA的脂联素水平较低[SMD = - 0.72 (- 1.00, - 0.44), P < 0.05]，而斑块表型的脂联素水平较高[SMD = 0.29 (0.11, 0.47), P < 0.05]。瘦素在CA中升高，对斑块表型有显著影响[SMD = 0.70 (0.13, 1.28), P = 0.02]。在不同表型的CA中，Omentin均较低[SMD = - 1.43 (- 2.20, - 0.66), P < 0.001]。敏感性分析支持脂联素的稳健性（排除健康队列后效果更强），发表偏倚评估仅适用于脂联素，结果为阴性。结论本研究表明，循环脂肪因子水平可作为CA的表型特异性生物标志物。
{"title":"Phenotype-specific associations of circulating adipokine levels with carotid atherosclerosis: a systematic review and meta-analysis","authors":"Shuo Yang , Hong Shen , Yukun You , Zhenyue Fu , Shuaijie Guo , Yifan Zhang , Qincheng Liu , Ying Yang , Ye Li , Ji Qin , Ping Liu","doi":"10.1016/j.ijcrp.2025.200543","DOIUrl":"10.1016/j.ijcrp.2025.200543","url":null,"abstract":"<div><h3>Background</h3><div>Atherosclerosis (AS) is driven by inflammatory and metabolic dysregulation. Carotid atherosclerosis (CA), assessable by ultrasonographic carotid intima–media thickness (cIMT) and plaque, provides a noninvasive window into AS. Adipose tissue–derived adipokines are involved in AS.</div></div><div><h3>Aim</h3><div>We conducted a phenotype-specific systematic review and meta-analysis of observational studies to quantify associations between circulating adipokines and CA.</div></div><div><h3>Methods</h3><div>Following a preregistered protocol, PubMed, Embase, and Web of Science were searched. Adults with ultrasound-defined CA (increased cIMT and/or carotid plaque) and controls were included. Mean and standard deviation (SD) of circulating adipokines were extracted and converted to standardized mean difference (SMD) for pooled analysis.</div></div><div><h3>Results</h3><div>Nineteen studies (n = 5860; Asia/Europe/Americas; 8 cross-sectional, 8 case-control, 3 cohort) were included for quantitative analysis. In the increased cIMT phenotype, adiponectin was lower in CA [SMD = −0.72 (−1.00, −0.44), <em>P</em> < 0.05], whereas in the plaque phenotype it was higher [SMD = 0.29 (0.11, 0.47), <em>P</em> < 0.05]. Leptin was higher in CA, reaching significance in the plaque phenotype [SMD = 0.70 (0.13, 1.28), P = 0.02]. Omentin was consistently lower in CA across phenotypes [SMD = −1.43 (−2.20, −0.66), P < 0.001]. Sensitivity analysis supported robustness for adiponectin (stronger effects after excluding healthy cohorts), and publication-bias assessment was feasible only for adiponectin and were negative.</div></div><div><h3>Conclusions</h3><div>This study indicated that circulating adipokine levels can serve as phenotype-specific biomarkers in CA.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"27 ","pages":"Article 200543"},"PeriodicalIF":2.1,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-11DOI: 10.1016/j.ijcrp.2025.200544
Entezar Mehrabi Nasab , Saeed Sadeghian , Ali Bozorgi , Hamidreza Fallahabadi , Vahid Toupchi-Khosroshahi , Seyyed Shamsadin Athari
Atrial fibrillation (AF) is the most common type of sustained arrhythmia with potentially serious complications and risk of mortality. Inflammation plays an indispensable role in the pathogenesis of AF, evidenced by the elevated levels of various cytokines such as C-reactive protein, macrophage migration inhibitor (MIF), interleukin-6 (Il-6), and tumor necrosis factor-α (TNF-α). Pulmonary veins (PVs) are the main site of AF initiation, where cells acquire arrhythmogenic properties under the effects of pro-inflammatory mediators. Calcium/calmodulin-dependent protein kinase II (CaMKII) signaling also plays a critical role in arrhythmogenesis, which is modulated by aberrant Ca2+ homeostasis and ion currents, as well as the electrophysiological properties of PVs influenced by inflammatory mediators, including MIF. Today, pulmonary vein isolation (PVI) is one of the main treatments for AF. This review aimed to outline our current understanding of the underlying mechanisms of AF in an effort to open a new window for discovering novel therapies for this type of arrhythmia.
{"title":"Immune responses and activity of inflammatory mediators in pulmonary vein arrhythmogenesis","authors":"Entezar Mehrabi Nasab , Saeed Sadeghian , Ali Bozorgi , Hamidreza Fallahabadi , Vahid Toupchi-Khosroshahi , Seyyed Shamsadin Athari","doi":"10.1016/j.ijcrp.2025.200544","DOIUrl":"10.1016/j.ijcrp.2025.200544","url":null,"abstract":"<div><div>Atrial fibrillation (AF) is the most common type of sustained arrhythmia with potentially serious complications and risk of mortality. Inflammation plays an indispensable role in the pathogenesis of AF, evidenced by the elevated levels of various cytokines such as C-reactive protein, macrophage migration inhibitor (MIF), interleukin-6 (Il-6), and tumor necrosis factor-α (TNF-α). Pulmonary veins (PVs) are the main site of AF initiation, where cells acquire arrhythmogenic properties under the effects of pro-inflammatory mediators. Calcium/calmodulin-dependent protein kinase II (CaMKII) signaling also plays a critical role in arrhythmogenesis, which is modulated by aberrant Ca2+ homeostasis and ion currents, as well as the electrophysiological properties of PVs influenced by inflammatory mediators, including MIF. Today, pulmonary vein isolation (PVI) is one of the main treatments for AF. This review aimed to outline our current understanding of the underlying mechanisms of AF in an effort to open a new window for discovering novel therapies for this type of arrhythmia.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"27 ","pages":"Article 200544"},"PeriodicalIF":2.1,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
With the growing demand for coronary artery visualization and the diagnosis of coronary artery disease, noninvasive coronary imaging modalities have gained significance. Coronary magnetic resonance angiography (CMRA) is a promising technique as it is noninvasive and does not involve ionizing radiation or iodinated contrast agents. Although certain limitations in this technology have prevented its application as a first-line clinical imaging modality, its immense developmental potential has positioned it as a focal point of research. This review discusses the advancements in CMRA across multiple technical domains—including motion correction, imaging acceleration, and integration with artificial intelligence—as well as its current clinical status and future prospects.
{"title":"Noninvasive coronary imaging: Technological breakthroughs and the integrated application of coronary magnetic resonance angiography","authors":"Yiming Sang, Shuang Li, Hui Wang, Hongkai Zhang, Baiyan Zhuang, Lei Xu","doi":"10.1016/j.ijcrp.2025.200542","DOIUrl":"10.1016/j.ijcrp.2025.200542","url":null,"abstract":"<div><div>With the growing demand for coronary artery visualization and the diagnosis of coronary artery disease, noninvasive coronary imaging modalities have gained significance. Coronary magnetic resonance angiography (CMRA) is a promising technique as it is noninvasive and does not involve ionizing radiation or iodinated contrast agents. Although certain limitations in this technology have prevented its application as a first-line clinical imaging modality, its immense developmental potential has positioned it as a focal point of research. This review discusses the advancements in CMRA across multiple technical domains—including motion correction, imaging acceleration, and integration with artificial intelligence—as well as its current clinical status and future prospects.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"27 ","pages":"Article 200542"},"PeriodicalIF":2.1,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-07DOI: 10.1016/j.ijcrp.2025.200539
Can Xu , Rishabh Khurana , Xuan Gao , Xinyu Nie , Constanze Lehertshuber , Ling Li , Amos Romer , Luigi Filippo Brizzi , Moritz von Scheidt , Anurag Yadav , T.B.S. Buxi , Teresa Trenkwalder , Jason Zhensheng Qu , Dongjin Wang , Zhifen Chen
Background
s: Epicardial adipose tissue (EAT) plays a crucial role in the development of coronary artery disease (CAD). This study aimed to evaluate the sex-specific relationship between EAT volume and CAD or its risk factors in an Indian cohort, filling the gap in data for the South Asian population.
Methods
The retrospective study included 950 subjects who underwent coronary computed tomography angiography (CCTA) from 2013 to 2016 at Sir Ganga Ram Hospital in India. The EAT volume and CAD status were examined. CAD risk factors such as age, body mass index (BMI), smoking, hypertension, diabetes, and cholesterol levels were documented. In a sex-specific fashion, the generalized additive model and multivariable logistic regression analyses were applied to assess the correlation between EAT volume and CAD or its risk factors. The two-piecewise linear regression model was applied to identify the inflection point for the nonlinear correlations.
Results
Results showed that EAT volume was larger in men than in women. A nonlinear relationship between EAT volume and CAD was identified in men but not in women, with an inflection point at 90 ml for men. The effect size of EAT volume on CAD was higher when EAT volume was below 90 ml. EAT volume was also linearly correlated with BMI in men. In the multivariable analysis, EAT volume was significantly associated with CAD and BMI in men, while no significant correlation was found in women.
Conclusion
These findings suggest that EAT volume is an independent indicator of CAD risk in men, particularly in non-obese individuals. The sex-specific differences emphasize the importance of personalized approaches to CAD risk assessment in the South Asian population.
背景：心外膜脂肪组织（EAT）在冠状动脉疾病（CAD）的发展中起着至关重要的作用。本研究旨在评估印度队列中EAT量与CAD或其危险因素之间的性别特异性关系，填补南亚人群数据的空白。方法回顾性研究纳入2013年至2016年在印度Sir Ganga Ram医院接受冠状动脉ct血管造影（CCTA）检查的950例受试者。检查EAT体积和CAD状态。冠心病的危险因素如年龄、身体质量指数（BMI）、吸烟、高血压、糖尿病和胆固醇水平被记录下来。以特定性别的方式，应用广义加性模型和多变量逻辑回归分析来评估EAT体积与CAD或其危险因素之间的相关性。采用两分段线性回归模型识别非线性相关性的拐点。结果结果显示，男性的胃泌酸量大于女性。在男性中发现了EAT容积和CAD之间的非线性关系，但在女性中没有发现，男性的拐点为90 ml。当EAT容积低于90 ml时，EAT容积对CAD的效应值更高。男性EAT容积与BMI也呈线性相关。在多变量分析中，男性的EAT体积与CAD和BMI显著相关，而女性没有发现显著相关。结论：这些发现表明，在男性中，尤其是在非肥胖人群中，EAT体积是CAD风险的独立指标。性别特异性差异强调了在南亚人群中进行CAD风险评估的个性化方法的重要性。
{"title":"Sex-specific association of epicardial adipose tissue with coronary artery disease in an Indian cohort: a cross-sectional study","authors":"Can Xu , Rishabh Khurana , Xuan Gao , Xinyu Nie , Constanze Lehertshuber , Ling Li , Amos Romer , Luigi Filippo Brizzi , Moritz von Scheidt , Anurag Yadav , T.B.S. Buxi , Teresa Trenkwalder , Jason Zhensheng Qu , Dongjin Wang , Zhifen Chen","doi":"10.1016/j.ijcrp.2025.200539","DOIUrl":"10.1016/j.ijcrp.2025.200539","url":null,"abstract":"<div><h3>Background</h3><div>s: Epicardial adipose tissue (EAT) plays a crucial role in the development of coronary artery disease (CAD). This study aimed to evaluate the sex-specific relationship between EAT volume and CAD or its risk factors in an Indian cohort, filling the gap in data for the South Asian population.</div></div><div><h3>Methods</h3><div>The retrospective study included 950 subjects who underwent coronary computed tomography angiography (CCTA) from 2013 to 2016 at Sir Ganga Ram Hospital in India. The EAT volume and CAD status were examined. CAD risk factors such as age, body mass index (BMI), smoking, hypertension, diabetes, and cholesterol levels were documented. In a sex-specific fashion, the generalized additive model and multivariable logistic regression analyses were applied to assess the correlation between EAT volume and CAD or its risk factors. The two-piecewise linear regression model was applied to identify the inflection point for the nonlinear correlations.</div></div><div><h3>Results</h3><div>Results showed that EAT volume was larger in men than in women. A nonlinear relationship between EAT volume and CAD was identified in men but not in women, with an inflection point at 90 ml for men. The effect size of EAT volume on CAD was higher when EAT volume was below 90 ml. EAT volume was also linearly correlated with BMI in men. In the multivariable analysis, EAT volume was significantly associated with CAD and BMI in men, while no significant correlation was found in women.</div></div><div><h3>Conclusion</h3><div>These findings suggest that EAT volume is an independent indicator of CAD risk in men, particularly in non-obese individuals. The sex-specific differences emphasize the importance of personalized approaches to CAD risk assessment in the South Asian population.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"27 ","pages":"Article 200539"},"PeriodicalIF":2.1,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-07DOI: 10.1016/j.ijcrp.2025.200541
Ruoyu Wang
Hypertensive Retinopathy is a common complication of hypertension, requiring timely diagnosis to prevent vision loss. Traditional diagnosis relies on manual examination of fundus images, which is time-consuming and subjective. To address this, we propose MA-DNet, a lightweight deep learning model combining DenseNet with channel and spatial attention mechanisms. Our approach leverages feature enhancement and data balancing techniques to improve classification accuracy. Evaluated on the OIA-ODIR dataset, MA-DNet achieves 95.8 % accuracy, outperforming existing methods. This study demonstrates the potential of attention mechanisms in enhancing HR classification for clinical decision support.
{"title":"A lightweight deep learning model with attention mechanisms for hypertensive retinopathy classification","authors":"Ruoyu Wang","doi":"10.1016/j.ijcrp.2025.200541","DOIUrl":"10.1016/j.ijcrp.2025.200541","url":null,"abstract":"<div><div>Hypertensive Retinopathy is a common complication of hypertension, requiring timely diagnosis to prevent vision loss. Traditional diagnosis relies on manual examination of fundus images, which is time-consuming and subjective. To address this, we propose MA-DNet, a lightweight deep learning model combining DenseNet with channel and spatial attention mechanisms. Our approach leverages feature enhancement and data balancing techniques to improve classification accuracy. Evaluated on the OIA-ODIR dataset, MA-DNet achieves 95.8 % accuracy, outperforming existing methods. This study demonstrates the potential of attention mechanisms in enhancing HR classification for clinical decision support.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"27 ","pages":"Article 200541"},"PeriodicalIF":2.1,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145525655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号