首页 > 最新文献

International Journal of Cardiology Cardiovascular Risk and Prevention最新文献

英文 中文
Position paper ITACARE-P/FADOI on the referral from internal medicine to cardiac rehabilitation: Executive summary and factsheet ITACARE-P/FADOI关于从内科转诊到心脏康复的立场文件:执行摘要和概况介绍
IF 2.3 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-06-01 DOI: 10.1016/j.ijcrp.2024.200275
Marco Ambrosetti , Francesco Fattirolli , Paola Gnerre , Franco Mastroianni , Gian Francesco Mureddu , Francesco Dentali , Francesco Giallauria , Michele Meschi , Alessandra Pratesi , Matteo Ruzzolini , Elio Venturini

The Italian Association for Cardiovascular Rehabilitation and Prevention (ITACARE-P) and the Italian Federation of Associations of Hospital Doctors on Internal Medicine (FADOI) released a joint position paper to guide referrals of cardiovascular patients discharged from Internal Medicine (IM) wards to Cardiac Rehabilitation (CR) facilities. The document provides rationale and operative recommendations for appropriateness (i.e. qualifying diagnoses) and priority criteria to overcome the mismatch between potential demand and effective supply of CR programmes. In case of no-referral due to logistic barriers, the document recommends the adoption of best alternatives to CR for disability reduction, better prognosis, and improvement of quality of life. The joint position paper is also aimed to promote the consideration of IM as a potential stakeholder of CR.

意大利心血管康复与预防协会(ITACARE-P)和意大利医院内科医生协会联合会(FADOI)发布了一份联合立场文件,旨在指导从内科(IM)病房出院的心血管病人转诊至心脏康复(CR)机构。该文件就适当性(即合格诊断)和优先标准提供了理论依据和操作建议,以克服 CR 项目潜在需求与有效供应之间的不匹配。在因后勤障碍而无法转诊的情况下,文件建议采用 CR 的最佳替代方案,以减少残疾、改善预后和提高生活质量。联合立场文件还旨在促进将 IM 视为 CR 的潜在利益攸关方。
{"title":"Position paper ITACARE-P/FADOI on the referral from internal medicine to cardiac rehabilitation: Executive summary and factsheet","authors":"Marco Ambrosetti ,&nbsp;Francesco Fattirolli ,&nbsp;Paola Gnerre ,&nbsp;Franco Mastroianni ,&nbsp;Gian Francesco Mureddu ,&nbsp;Francesco Dentali ,&nbsp;Francesco Giallauria ,&nbsp;Michele Meschi ,&nbsp;Alessandra Pratesi ,&nbsp;Matteo Ruzzolini ,&nbsp;Elio Venturini","doi":"10.1016/j.ijcrp.2024.200275","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200275","url":null,"abstract":"<div><p>The Italian Association for Cardiovascular Rehabilitation and Prevention (ITACARE-P) and the Italian Federation of Associations of Hospital Doctors on Internal Medicine (FADOI) released a joint position paper to guide referrals of cardiovascular patients discharged from Internal Medicine (IM) wards to Cardiac Rehabilitation (CR) facilities. The document provides rationale and operative recommendations for appropriateness (i.e. qualifying diagnoses) and priority criteria to overcome the mismatch between potential demand and effective supply of CR programmes. In case of no-referral due to logistic barriers, the document recommends the adoption of best alternatives to CR for disability reduction, better prognosis, and improvement of quality of life. The joint position paper is also aimed to promote the consideration of IM as a potential stakeholder of CR.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200275"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000400/pdfft?md5=547cac32d2f40a66c7d6662f3454beb0&pid=1-s2.0-S2772487524000400-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
41Bridging the gender gap in Cardiac Rehabilitation. The first step: The equal opportunities project 41 缩小心脏康复中的性别差距。第一步:平等机会项目
IF 2.3 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-06-01 DOI: 10.1016/j.ijcrp.2024.200268
Elisabetta Angelino

Women receive similar or greater benefits than men from Cardiac Rehabilitation (CR). However, they are less likely to participate. An integrated and gender-sensitive approach to cardiovascular disease is required to enhance the quality and experience of care for women with different cardiovascular issues throughout their lives.

The Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P) is committed to developing a gender-specific approach to CR that will more effectively meet the needs of both women and men.

女性从心脏康复(CR)中获得的益处与男性相似或更多。然而,她们参与的可能性较小。意大利心血管康复与预防联盟(ITACARE-P)致力于开发一种针对不同性别的心脏康复方法,以更有效地满足女性和男性的需求。
{"title":"41Bridging the gender gap in Cardiac Rehabilitation. The first step: The equal opportunities project","authors":"Elisabetta Angelino","doi":"10.1016/j.ijcrp.2024.200268","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200268","url":null,"abstract":"<div><p>Women receive similar or greater benefits than men from Cardiac Rehabilitation (CR). However, they are less likely to participate. An integrated and gender-sensitive approach to cardiovascular disease is required to enhance the quality and experience of care for women with different cardiovascular issues throughout their lives.</p><p>The Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P) is committed to developing a gender-specific approach to CR that will more effectively meet the needs of both women and men.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200268"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000333/pdfft?md5=6cc1d0225a067fede5e8f931a690a21f&pid=1-s2.0-S2772487524000333-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rehabilitation post pulmonary embolism: Preliminary data 肺栓塞后的康复治疗:初步数据
IF 2.3 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-06-01 DOI: 10.1016/j.ijcrp.2024.200269
Michele Azzarito , Carmela Fabiano , Roberto Bellini , Matteo Ruzzolini
{"title":"Rehabilitation post pulmonary embolism: Preliminary data","authors":"Michele Azzarito ,&nbsp;Carmela Fabiano ,&nbsp;Roberto Bellini ,&nbsp;Matteo Ruzzolini","doi":"10.1016/j.ijcrp.2024.200269","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200269","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200269"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000345/pdfft?md5=1230d239bde670126d1a5002ce4a2895&pid=1-s2.0-S2772487524000345-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Indicators of nutritional status and patient needs in cardiac rehabilitation 心脏康复中的营养状况和患者需求指标
IF 2.3 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-06-01 DOI: 10.1016/j.ijcrp.2024.200270
Letizia da Vico

Background

The prevalence and incidence of cardiovascular diseases significantly increase with age, and it is well-known that nutritional status affects the prognosis and treatment of these diseases. Therefore, evaluating nutritional status is essential for maintaining/regaining health. It is crucial to identify nutritional risk early, prevent and/or treat protein-energy malnutrition, and promote the modification of inappropriate dietary habits.

Methods

Nutritional screening represents the first step of access to the Nutrition Care Process (NCP) adopted and managed by the dietitian; this tool must be simple, inexpensive, accessible, accurate, efficient, and validated. A globally accepted standardized definition of malnutrition is necessary, and for this reason, the Global Leadership Initiative on Malnutrition (GLIM) criteria have been recently introduced.

The GLIM criteria, after confirming nutritional risk through screening, include both phenotypic and etiological criteria: to diagnose malnutrition, at least one of these must be present.

A less commonly performed phenotypic criterion is the assessment of muscle mass, which should be studied as a significant component of sarcopenia.

Conclusion

Greater attention to the identification and treatment of malnutrition would bring benefits to patients and ensure a saving in healthcare expenditure, but for this purpose, an implementation of clinical nutrition services is necessary.

背景心血管疾病的患病率和发病率随着年龄的增长而显著增加,众所周知,营养状况会影响这些疾病的预后和治疗。因此,评估营养状况对维持/恢复健康至关重要。方法营养筛查是营养师采用和管理营养护理程序(NCP)的第一步;这一工具必须简单、廉价、方便、准确、高效并经过验证。通过筛查确认营养风险后,GLIM 标准包括表型标准和病因标准:要诊断营养不良,必须至少具备其中一项标准。一个较少采用的表型标准是肌肉质量评估,应将其作为肌少症的一个重要组成部分进行研究。结论对营养不良的识别和治疗给予更多关注将为患者带来益处,并确保节省医疗开支,但为此目的,有必要实施临床营养服务。
{"title":"Indicators of nutritional status and patient needs in cardiac rehabilitation","authors":"Letizia da Vico","doi":"10.1016/j.ijcrp.2024.200270","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200270","url":null,"abstract":"<div><h3>Background</h3><p>The prevalence and incidence of cardiovascular diseases significantly increase with age, and it is well-known that nutritional status affects the prognosis and treatment of these diseases. Therefore, evaluating nutritional status is essential for maintaining/regaining health. It is crucial to identify nutritional risk early, prevent and/or treat protein-energy malnutrition, and promote the modification of inappropriate dietary habits.</p></div><div><h3>Methods</h3><p>Nutritional screening represents the first step of access to the Nutrition Care Process (NCP) adopted and managed by the dietitian; this tool must be simple, inexpensive, accessible, accurate, efficient, and validated. A globally accepted standardized definition of malnutrition is necessary, and for this reason, the Global Leadership Initiative on Malnutrition (GLIM) criteria have been recently introduced.</p><p>The GLIM criteria, after confirming nutritional risk through screening, include both phenotypic and etiological criteria: to diagnose malnutrition, at least one of these must be present.</p><p>A less commonly performed phenotypic criterion is the assessment of muscle mass, which should be studied as a significant component of sarcopenia.</p></div><div><h3>Conclusion</h3><p>Greater attention to the identification and treatment of malnutrition would bring benefits to patients and ensure a saving in healthcare expenditure, but for this purpose, an implementation of clinical nutrition services is necessary.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200270"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000357/pdfft?md5=9b643f5c811d8c8904d2450799e9d61a&pid=1-s2.0-S2772487524000357-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging Lp(a)-Lowering therapies: Is muvalaplin a potential breakthrough? 降低脂蛋白(a)的新兴疗法:muvalaplin是一个潜在的突破口吗?
IF 2.3 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-06-01 DOI: 10.1016/j.ijcrp.2024.200262
Zeeshan Afzal , Sara Hira , Huili Cao
{"title":"Emerging Lp(a)-Lowering therapies: Is muvalaplin a potential breakthrough?","authors":"Zeeshan Afzal ,&nbsp;Sara Hira ,&nbsp;Huili Cao","doi":"10.1016/j.ijcrp.2024.200262","DOIUrl":"10.1016/j.ijcrp.2024.200262","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200262"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000278/pdfft?md5=52ae11375f8a3958f8fdf578a845202e&pid=1-s2.0-S2772487524000278-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140404523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac amyloidosis red flags: What all the cardiologist have to know 心脏淀粉样变性红旗:心脏病医生必须知道的事情
IF 2.3 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-06-01 DOI: 10.1016/j.ijcrp.2024.200271
Alessandro Maloberti , Claudio Ciampi , Francesco Politi , Saverio Fabbri , Francesco Musca , Cristina Giannattasio

Cardiac amyloidosis is becoming increasingly important among cardiologist and an early diagnosis is very important. Amyloidosis is a systemic disease and many cardiac and extracardiac elements (red flags) should raise the suspicion of the disease. Electrocardiographic and imaging techniques (such as echocardiography, cardiac magnetic resonance and scintigraphy) are useful tools to make a diagnosis together with the presence of orthopedic issues, peripheral neuropathy or plasma cell dyscrasia. Cardiac amyloidosis is also often associated with valvular disorder, heart failure or cardiomyopathy. Red flags are crucial to raise suspicion and reach an early diagnosis, in order to start a targeted treatment strategy that could change the patient's outcome. Indeed, in the last years four new drugs were approved to treat transthyretin amyloidosis.

心脏淀粉样变性在心脏病专家中的地位日益重要,早期诊断非常重要。淀粉样变性是一种全身性疾病,许多心脏和心脏外因素(红旗)都应引起对该疾病的怀疑。心电图和成像技术(如超声心动图、心脏磁共振和闪烁照相)以及骨科疾病、周围神经病变或浆细胞异常是诊断的有用工具。心脏淀粉样变性还常常伴有瓣膜病、心力衰竭或心肌病。红旗是引起怀疑和早期诊断的关键,以便开始有针对性的治疗策略,从而改变患者的预后。事实上,在过去几年中,已经有四种治疗转甲状腺素淀粉样变性病的新药获得批准。
{"title":"Cardiac amyloidosis red flags: What all the cardiologist have to know","authors":"Alessandro Maloberti ,&nbsp;Claudio Ciampi ,&nbsp;Francesco Politi ,&nbsp;Saverio Fabbri ,&nbsp;Francesco Musca ,&nbsp;Cristina Giannattasio","doi":"10.1016/j.ijcrp.2024.200271","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200271","url":null,"abstract":"<div><p>Cardiac amyloidosis is becoming increasingly important among cardiologist and an early diagnosis is very important. Amyloidosis is a systemic disease and many cardiac and extracardiac elements (red flags) should raise the suspicion of the disease. Electrocardiographic and imaging techniques (such as echocardiography, cardiac magnetic resonance and scintigraphy) are useful tools to make a diagnosis together with the presence of orthopedic issues, peripheral neuropathy or plasma cell dyscrasia. Cardiac amyloidosis is also often associated with valvular disorder, heart failure or cardiomyopathy. Red flags are crucial to raise suspicion and reach an early diagnosis, in order to start a targeted treatment strategy that could change the patient's outcome. Indeed, in the last years four new drugs were approved to treat transthyretin amyloidosis.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200271"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000369/pdfft?md5=82695930583ce0e9b5824df165f8db8f&pid=1-s2.0-S2772487524000369-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging risks of microplastics and nanoplastics (MNPs): Is a silent threat for cardiovascular disease? 微塑料和纳米塑料(MNPs)的新风险:对心血管疾病的威胁是否无声无息?
IF 2.3 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-06-01 DOI: 10.1016/j.ijcrp.2024.200280
Zeeshan Afzal, Abdul Basit, Usama Habib, Mateen Aman, Muhammad Azim, Huili Cao
{"title":"Emerging risks of microplastics and nanoplastics (MNPs): Is a silent threat for cardiovascular disease?","authors":"Zeeshan Afzal,&nbsp;Abdul Basit,&nbsp;Usama Habib,&nbsp;Mateen Aman,&nbsp;Muhammad Azim,&nbsp;Huili Cao","doi":"10.1016/j.ijcrp.2024.200280","DOIUrl":"10.1016/j.ijcrp.2024.200280","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200280"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277248752400045X/pdfft?md5=a163542ae81fcc5ef1bc68ad77f4cfd5&pid=1-s2.0-S277248752400045X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141030184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac contractility modulation in patients with heart failure: The added value of cardiac rehabilitation in identification, management, and follow-up 心力衰竭患者的心肌收缩力调节:心脏康复在识别、管理和随访方面的附加价值
IF 2.3 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-06-01 DOI: 10.1016/j.ijcrp.2024.200284
Matteo Ruzzolini , Francesco Giallauria , Francesco Fattirolli , Elio Venturini , Francesco Maranta , Gian Francesco Mureddu , Pasqualina Calisi , Raffaele Griffo , Carlo Vigorito , Pompilio Faggiano , Marco Ambrosetti , Daniele Masarone
{"title":"Cardiac contractility modulation in patients with heart failure: The added value of cardiac rehabilitation in identification, management, and follow-up","authors":"Matteo Ruzzolini ,&nbsp;Francesco Giallauria ,&nbsp;Francesco Fattirolli ,&nbsp;Elio Venturini ,&nbsp;Francesco Maranta ,&nbsp;Gian Francesco Mureddu ,&nbsp;Pasqualina Calisi ,&nbsp;Raffaele Griffo ,&nbsp;Carlo Vigorito ,&nbsp;Pompilio Faggiano ,&nbsp;Marco Ambrosetti ,&nbsp;Daniele Masarone","doi":"10.1016/j.ijcrp.2024.200284","DOIUrl":"10.1016/j.ijcrp.2024.200284","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200284"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000497/pdfft?md5=88af6704ab6c80e4816f010bc3346500&pid=1-s2.0-S2772487524000497-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141057828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Takotsubo syndrome as an acute cardiac complication following combined chemotherapy 联合化疗后的急性心脏并发症--塔克次氏综合征
IF 2.3 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-05-31 DOI: 10.1016/j.ijcrp.2024.200292
H.A. Nati-Castillo , David Aristizabal-Colorado , Carolina López Ordoñez , Diego Egas Proaño , Esteban Ortiz-Prado , Juan S. Izquierdo-Condoy

Background

Acute cardiac complications post-chemotherapy is rare. Stress cardiomyopathy, one of these complications, should be considered in differential diagnoses as its symptoms closely resemble those of acute myocardial infarction and can lead to mortality.

Objective

The objective of this paper is to describe Takotsubo syndrome (TTS) as an acute complication following combined chemotherapy in a patient with significant thromboembolic burden and metastatic cervical cancer.

Case

A 61-year-old female patient with a diagnosis of metastatic cervical cancer experienced acute chest pain. Elevated troponin levels and abnormalities in the electrocardiogram initially suggested an acute myocardial infarction, occurring after a chemotherapy session involving Carboplatin and Paclitaxel infusion. Although initial treatment targeted myocardial infarction, further diagnostic evaluations including coronary angiography and cardiac magnetic resonance imaging revealed no coronary artery disease but identified features consistent with stress cardiomyopathy, indicative of Takotsubo syndrome (TTS). This diagnosis led to an improvement in symptoms and a resolution of the acute changes observed.

Conclusion

Stress cardiomyopathy, particularly TTS, is being increasingly recognized as an acute complication associated with combined chemotherapy regimens. The potential cardiotoxic effects of these chemotherapy agents demand careful monitoring and evaluation in patients undergoing oncological treatment, underscoring the importance of integrating cardioprotective strategies into the management of these patients.

背景化疗后急性心脏并发症非常罕见。应激性心肌病是这些并发症中的一种,应在鉴别诊断中予以考虑,因为其症状与急性心肌梗死的症状非常相似,并可导致死亡。本文旨在描述塔克次氏综合征(TTS),它是一名有严重血栓栓塞负担和转移性宫颈癌患者在联合化疗后出现的急性并发症。肌钙蛋白水平升高和心电图异常最初提示为急性心肌梗死,发生在输注卡铂和紫杉醇的化疗后。虽然最初的治疗以心肌梗死为目标,但包括冠状动脉造影和心脏磁共振成像在内的进一步诊断评估显示,患者没有冠状动脉疾病,但发现了与应激性心肌病一致的特征,表明患者患有塔克次氏综合征(TTS)。结论应激性心肌病,尤其是 TTS,越来越多地被认为是与联合化疗方案相关的急性并发症。这些化疗药物的潜在心脏毒性作用要求对接受肿瘤治疗的患者进行仔细的监测和评估,这也凸显了将心脏保护策略纳入这些患者管理的重要性。
{"title":"Takotsubo syndrome as an acute cardiac complication following combined chemotherapy","authors":"H.A. Nati-Castillo ,&nbsp;David Aristizabal-Colorado ,&nbsp;Carolina López Ordoñez ,&nbsp;Diego Egas Proaño ,&nbsp;Esteban Ortiz-Prado ,&nbsp;Juan S. Izquierdo-Condoy","doi":"10.1016/j.ijcrp.2024.200292","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200292","url":null,"abstract":"<div><h3>Background</h3><p>Acute cardiac complications post-chemotherapy is rare. Stress cardiomyopathy, one of these complications, should be considered in differential diagnoses as its symptoms closely resemble those of acute myocardial infarction and can lead to mortality.</p></div><div><h3>Objective</h3><p>The objective of this paper is to describe Takotsubo syndrome (TTS) as an acute complication following combined chemotherapy in a patient with significant thromboembolic burden and metastatic cervical cancer.</p></div><div><h3>Case</h3><p>A 61-year-old female patient with a diagnosis of metastatic cervical cancer experienced acute chest pain. Elevated troponin levels and abnormalities in the electrocardiogram initially suggested an acute myocardial infarction, occurring after a chemotherapy session involving Carboplatin and Paclitaxel infusion. Although initial treatment targeted myocardial infarction, further diagnostic evaluations including coronary angiography and cardiac magnetic resonance imaging revealed no coronary artery disease but identified features consistent with stress cardiomyopathy, indicative of Takotsubo syndrome (TTS). This diagnosis led to an improvement in symptoms and a resolution of the acute changes observed.</p></div><div><h3>Conclusion</h3><p>Stress cardiomyopathy, particularly TTS, is being increasingly recognized as an acute complication associated with combined chemotherapy regimens. The potential cardiotoxic effects of these chemotherapy agents demand careful monitoring and evaluation in patients undergoing oncological treatment, underscoring the importance of integrating cardioprotective strategies into the management of these patients.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200292"},"PeriodicalIF":2.3,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000576/pdfft?md5=bb7fbb4891a2536b1f96af8c86c64fdc&pid=1-s2.0-S2772487524000576-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141239743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical outcomes of upfront combination therapy for portopulmonary hypertension 门肺动脉高压前期综合疗法的临床疗效
IF 2.3 Q3 PERIPHERAL VASCULAR DISEASE Pub Date : 2024-05-31 DOI: 10.1016/j.ijcrp.2024.200294
Takatoyo Kiko , Ryotaro Asano , Hiroyuki Endo , Naruhiro Nishi , Hiroya Hayashi , Jin Ueda , Tatsuo Aoki , Akihiro Tsuji , Takeshi Ogo

Background

Limited data exists on upfront combination therapy for portopulmonary hypertension. We evaluated the clinical efficacy, long-term outcomes, and safety of upfront combination therapy in patients with portopulmonary hypertension.

Methods

We performed a retrospective, single-center cohort study involving a final analysis of 33 consecutive patients diagnosed with portopulmonary hypertension who were taking pulmonary arterial hypertension-specific medication. We compared hemodynamic parameters, risk profiles, composite clinical worsening events, and safety between monotherapy (n = 23) and upfront combination therapy (n = 10).

Results

Twenty-seven patients (82 %) were classified into the Child–Pugh A stage. The change ratios of pulmonary vascular resistance (−32 % vs. −57 %, P = 0.006) were significantly better with upfront combination therapy. Upfront combination therapy also showed significant improvement in risk profiles. Kaplan–Meier analysis showed that the composite event-free rate was significantly lower in patients who received upfront combination therapy than in those who received monotherapy (P = 0.016), although no statistical differences were observed in all-cause death. In the univariate Cox proportional hazards analysis, upfront combination therapy was a factor for decreasing composite clinical worsening outcomes (hazard ratio 0.190, 95 % confidence interval 0.042–0.854; P = 0.030). No significant hepatic impairments were observed over 2 years of follow-up in the upfront combination group.

Conclusions

In patients with portopulmonary hypertension, upfront combination therapy significantly improved symptoms and short-term hemodynamics, and reduced long-term clinical worsening events without serious adverse effects. This study's findings suggest that patients with portopulmonary hypertension presenting with mild hepatic impairment benefit from upfront combination therapy.

背景有关门肺动脉高压前期联合治疗的数据有限。我们评估了门静脉高压患者前期联合治疗的临床疗效、长期预后和安全性。方法 我们进行了一项回顾性单中心队列研究,最终分析了 33 名连续确诊患有门静脉高压且正在服用肺动脉高压特异性药物的患者。我们比较了单药治疗(23 例)和前期联合治疗(10 例)的血流动力学参数、风险概况、综合临床恶化事件和安全性。肺血管阻力的变化比率(-32 % 对 -57 %,P = 0.006)明显优于前期联合疗法。前期联合疗法也明显改善了风险状况。卡普兰-梅耶尔分析显示,接受前期联合疗法的患者的复合无事件发生率明显低于接受单一疗法的患者(P = 0.016),但在全因死亡方面未观察到统计学差异。在单变量考克斯比例危险分析中,前期联合疗法是降低综合临床恶化结果的一个因素(危险比为0.190,95%置信区间为0.042-0.854;P = 0.030)。结论 在门静脉高压症患者中,前期联合治疗可显著改善症状和短期血流动力学,并减少长期临床恶化事件,且无严重不良反应。本研究结果表明,伴有轻度肝功能损害的门静脉高压症患者可从前期联合治疗中获益。
{"title":"Clinical outcomes of upfront combination therapy for portopulmonary hypertension","authors":"Takatoyo Kiko ,&nbsp;Ryotaro Asano ,&nbsp;Hiroyuki Endo ,&nbsp;Naruhiro Nishi ,&nbsp;Hiroya Hayashi ,&nbsp;Jin Ueda ,&nbsp;Tatsuo Aoki ,&nbsp;Akihiro Tsuji ,&nbsp;Takeshi Ogo","doi":"10.1016/j.ijcrp.2024.200294","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200294","url":null,"abstract":"<div><h3>Background</h3><p>Limited data exists on upfront combination therapy for portopulmonary hypertension. We evaluated the clinical efficacy, long-term outcomes, and safety of upfront combination therapy in patients with portopulmonary hypertension.</p></div><div><h3>Methods</h3><p>We performed a retrospective, single-center cohort study involving a final analysis of 33 consecutive patients diagnosed with portopulmonary hypertension who were taking pulmonary arterial hypertension-specific medication. We compared hemodynamic parameters, risk profiles, composite clinical worsening events, and safety between monotherapy (n = 23) and upfront combination therapy (n = 10).</p></div><div><h3>Results</h3><p>Twenty-seven patients (82 %) were classified into the Child–Pugh A stage. The change ratios of pulmonary vascular resistance (−32 % vs. −57 %, P = 0.006) were significantly better with upfront combination therapy. Upfront combination therapy also showed significant improvement in risk profiles. Kaplan–Meier analysis showed that the composite event-free rate was significantly lower in patients who received upfront combination therapy than in those who received monotherapy (P = 0.016), although no statistical differences were observed in all-cause death. In the univariate Cox proportional hazards analysis, upfront combination therapy was a factor for decreasing composite clinical worsening outcomes (hazard ratio 0.190, 95 % confidence interval 0.042–0.854; P = 0.030). No significant hepatic impairments were observed over 2 years of follow-up in the upfront combination group.</p></div><div><h3>Conclusions</h3><p>In patients with portopulmonary hypertension, upfront combination therapy significantly improved symptoms and short-term hemodynamics, and reduced long-term clinical worsening events without serious adverse effects. This study's findings suggest that patients with portopulmonary hypertension presenting with mild hepatic impairment benefit from upfront combination therapy.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"22 ","pages":"Article 200294"},"PeriodicalIF":2.3,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277248752400059X/pdfft?md5=05e38f9b9c971dcf588cf7bd1f11bc24&pid=1-s2.0-S277248752400059X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141239737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
International Journal of Cardiology Cardiovascular Risk and Prevention
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1