Pub Date : 2024-06-01DOI: 10.1016/j.ijcrp.2024.200273
Giulia Nicolaio , Samuele Baldasseroni , Maria Vittoria Silverii , Francesca Marchetti , Costanza Burgisser , Davide Montini , Francesco Orso , Alessandra Pratesi , Andrea Ungar , Niccolò Marchionni , Francesco Fattirolli
Introduction
The positive effect of cardiac rehabilitation (CR) is demonstrated in younger and older patients. However, it is quite debated whether the beneficial effect is similarly maintained in both genders during follow-up.
Aim
to determine if the improvement obtained after CR remained significant at 1-year follow-up in older population, testing the influence of gender on this outcome.
Methods
All patients aged 75+ years consecutively referred to Cardiac Rehabilitation outpatient Unit at Careggi University Hospital were screened for eligibility. All patients attended a CR program, based on 5-day-per-week aerobic training sessions for 4 weeks and they were evaluated at the end of CR at 6 and 12 months of follow-up.
Results
361 patients with a mean age 80.6 ± 4.4 years with a complete 1-year follow-up were enrolled in the study, 87.5 % of them had an acute coronary event, and 27.6 % were females. The increase in exercise capacity at the end of CR and at 1-year follow-up was statistically significant (VO2 peak: +8.7 % in males p < 0.001, +8.5 % in females p < 0.001; distance walked at 6-min test: +7.3 % in males p < 0.001, +10.2 % in females p < 0.001, respectively); the trajectory of exercise improvement at 6 and 12 months of FU was similar in men and women without significant decrease (VO2 peak-ml/kg/min: CR discharge vs 1 year FU = 15.2 vs 15,0 p: NS; distance walked-meters: CR discharge vs 1 year FU = 445.5 vs 440.6, p: NS) from end of CR to 1-year.
Conclusions
the improvement in exercise tolerance obtained with CR program is still maintained at 1-year FU without significant influence of gender in our very old population.
导言:心脏康复(CR)对年轻和老年患者都有积极作用。方法筛选所有连续转诊至凯瑞吉大学医院心脏康复门诊部的 75 岁以上患者。结果361名平均年龄为(80.6±4.4)岁、随访时间为1年的患者参加了研究,其中87.5%的患者曾发生过急性冠状动脉事件,27.6%为女性。在 CR 结束时和随访 1 年后,运动能力的提高具有显著的统计学意义(VO2 峰值:男性 +8.7 %,女性 +8.7 %,男性 +8.7 %,女性 +8.7 %):男性为 +8.7 % p < 0.001,女性为 +8.5 % p < 0.001;6 分钟测试步行距离:分别为男性 +7.3 % p < 0.001,女性 +10.2 % p < 0.001);男性和女性在 FU 6 个月和 12 个月时的运动改善轨迹相似,没有显著下降(VO2 峰值-ml/kg/min:CR 出院 vs FU 1 年 = 15.2 vs 15,0 p. NS;步行距离-米:CR 出院 vs FU 1 年 = 15.2 vs 15,0 p. NS;步行距离-米:CR 出院 vs FU 1 年 = 15.2 vs 15,0 p. NS):NS;步行距离-米:CR出院 vs 1年FU = 445.5 vs 440.6, p. NS):结论:在我们的高龄人群中,通过 CR 计划获得的运动耐量改善在 1 年的 FU 中仍能保持,性别没有显著影响。
{"title":"Gender difference in long-term effect of cardiac rehabilitation; data from CRAGE-extra study","authors":"Giulia Nicolaio , Samuele Baldasseroni , Maria Vittoria Silverii , Francesca Marchetti , Costanza Burgisser , Davide Montini , Francesco Orso , Alessandra Pratesi , Andrea Ungar , Niccolò Marchionni , Francesco Fattirolli","doi":"10.1016/j.ijcrp.2024.200273","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200273","url":null,"abstract":"<div><h3>Introduction</h3><p>The positive effect of cardiac rehabilitation (CR) is demonstrated in younger and older patients. However, it is quite debated whether the beneficial effect is similarly maintained in both genders during follow-up.</p></div><div><h3>Aim</h3><p>to determine if the improvement obtained after CR remained significant at 1-year follow-up in older population, testing the influence of gender on this outcome.</p></div><div><h3>Methods</h3><p>All patients aged 75+ years consecutively referred to Cardiac Rehabilitation outpatient Unit at Careggi University Hospital were screened for eligibility. All patients attended a CR program, based on 5-day-per-week aerobic training sessions for 4 weeks and they were evaluated at the end of CR at 6 and 12 months of follow-up.</p></div><div><h3>Results</h3><p>361 patients with a mean age 80.6 ± 4.4 years with a complete 1-year follow-up were enrolled in the study, 87.5 % of them had an acute coronary event, and 27.6 % were females. The increase in exercise capacity at the end of CR and at 1-year follow-up was statistically significant (VO2 peak: +8.7 % in males p < 0.001, +8.5 % in females p < 0.001; distance walked at 6-min test: +7.3 % in males p < 0.001, +10.2 % in females p < 0.001, respectively); the trajectory of exercise improvement at 6 and 12 months of FU was similar in men and women without significant decrease (VO2 peak-ml/kg/min: CR discharge vs 1 year FU = 15.2 vs 15,0 p: NS; distance walked-meters: CR discharge vs 1 year FU = 445.5 vs 440.6, p: NS) from end of CR to 1-year.</p></div><div><h3>Conclusions</h3><p>the improvement in exercise tolerance obtained with CR program is still maintained at 1-year FU without significant influence of gender in our very old population.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200273"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000382/pdfft?md5=987bf53d191bc025b8a7fe073f1ce788&pid=1-s2.0-S2772487524000382-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Framingham risk score (FRS) and Atherosclerotic Cardiovascular Disease risk score (ASCVDrs) are widely used tools developed based on the American population. This study aimed to compare the ASCVDrs and FRS in an Iranian population.
Method
The participants of the Fasa Adult Cohort Study and the patients of the cardiovascular database of Vali-Asr Hospital of Fasa, aged 40–80 years, were involved in the present cross-sectional study. After excluding non-eligible participants, the individuals with a history of myocardial infarction or admission to the cardiology ward due to heart failure were considered high-risk, and the others were considered low-risk. The discriminative ability of FRS and ASCVDrs was evaluated and compared using receiver operating characteristic curve analysis. The correlation and agreement of ASCVDrs and FRS were tested using Cohen Kappa and Spearman.
Results
Finally, 8983 individuals (mean age:53.9 ± 9.5 y, 49.2 % male), including 1827 high-risk participants, entered the study. ASCVDrs detected a greater portion of participants as high-risk in comparison with FRS (28.7 % vs. 15.7 %). ASVD (AUC:0.794) had a higher discriminative ability than FRS (AUC:0.746), and both showed better discrimination in women. Optimal cut-off points for both ASCVDrs (4.36 %) and FRS (9.05 %) were lower than the original ones and in men. Compared to FRS, ASCVDrs had a higher sensitivity (79.3 % vs. 71.6 %) and lower specificity (64.5 % vs. 65.1 %). FRS and ASCVDrs had a moderate agreement (kappa:0.593,p-value<0.001) and were significantly correlated (Spearman:0.772,p-value<0.001).
Conclusions
ASCVDrs had a more accurate prediction of cardiovascular events and identified a larger number of people as high-risk in the Iranian population.
{"title":"Comparison of atherosclerotic cardiovascular disease (ASCVD) and Framingham risk scores (FRS) in an Iranian population","authors":"Matin Sepehrinia , Hossein Pourmontaseri , Mehrab Sayadi , Mohammad Mehdi Naghizadeh , Reza Homayounfar , Mojtaba Farjam , Azizallah Dehghan , Abdulhakim Alkamel","doi":"10.1016/j.ijcrp.2024.200287","DOIUrl":"10.1016/j.ijcrp.2024.200287","url":null,"abstract":"<div><h3>Background</h3><p>Framingham risk score (FRS) and Atherosclerotic Cardiovascular Disease risk score (ASCVDrs) are widely used tools developed based on the American population. This study aimed to compare the ASCVDrs and FRS in an Iranian population.</p></div><div><h3>Method</h3><p>The participants of the Fasa Adult Cohort Study and the patients of the cardiovascular database of Vali-Asr Hospital of Fasa, aged 40–80 years, were involved in the present cross-sectional study. After excluding non-eligible participants, the individuals with a history of myocardial infarction or admission to the cardiology ward due to heart failure were considered high-risk, and the others were considered low-risk. The discriminative ability of FRS and ASCVDrs was evaluated and compared using receiver operating characteristic curve analysis. The correlation and agreement of ASCVDrs and FRS were tested using Cohen Kappa and Spearman.</p></div><div><h3>Results</h3><p>Finally, 8983 individuals (mean age:53.9 ± 9.5 y, 49.2 % male), including 1827 high-risk participants, entered the study. ASCVDrs detected a greater portion of participants as high-risk in comparison with FRS (28.7 % vs. 15.7 %). ASVD (AUC:0.794) had a higher discriminative ability than FRS (AUC:0.746), and both showed better discrimination in women. Optimal cut-off points for both ASCVDrs (4.36 %) and FRS (9.05 %) were lower than the original ones and in men. Compared to FRS, ASCVDrs had a higher sensitivity (79.3 % vs. 71.6 %) and lower specificity (64.5 % vs. 65.1 %). FRS and ASCVDrs had a moderate agreement (kappa:0.593,<em>p</em>-value<0.001) and were significantly correlated (Spearman:0.772,<em>p</em>-value<0.001).</p></div><div><h3>Conclusions</h3><p>ASCVDrs had a more accurate prediction of cardiovascular events and identified a larger number of people as high-risk in the Iranian population.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200287"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000527/pdfft?md5=9b720b85c13a848f10fdf7f8fbb6b239&pid=1-s2.0-S2772487524000527-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141143378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.ijcrp.2024.200272
Francesco Maranta , Francesca Buffoli , Vittorio Giudici , Gabriella Malfatto , Alessandro Maloberti , Luigi Maresca , Bruno Passaretti , Anna Torri , Roberto Turato , Marco Ambrosetti
{"title":"Treatment of obesity with liraglutide in cardiovascular prevention: Case series by the “ITACARE-P Light-Heart Lab” working group","authors":"Francesco Maranta , Francesca Buffoli , Vittorio Giudici , Gabriella Malfatto , Alessandro Maloberti , Luigi Maresca , Bruno Passaretti , Anna Torri , Roberto Turato , Marco Ambrosetti","doi":"10.1016/j.ijcrp.2024.200272","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200272","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200272"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000370/pdfft?md5=8cdaeda168f6dedddc27e2ef49cb3172&pid=1-s2.0-S2772487524000370-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.ijcrp.2024.200275
Marco Ambrosetti , Francesco Fattirolli , Paola Gnerre , Franco Mastroianni , Gian Francesco Mureddu , Francesco Dentali , Francesco Giallauria , Michele Meschi , Alessandra Pratesi , Matteo Ruzzolini , Elio Venturini
The Italian Association for Cardiovascular Rehabilitation and Prevention (ITACARE-P) and the Italian Federation of Associations of Hospital Doctors on Internal Medicine (FADOI) released a joint position paper to guide referrals of cardiovascular patients discharged from Internal Medicine (IM) wards to Cardiac Rehabilitation (CR) facilities. The document provides rationale and operative recommendations for appropriateness (i.e. qualifying diagnoses) and priority criteria to overcome the mismatch between potential demand and effective supply of CR programmes. In case of no-referral due to logistic barriers, the document recommends the adoption of best alternatives to CR for disability reduction, better prognosis, and improvement of quality of life. The joint position paper is also aimed to promote the consideration of IM as a potential stakeholder of CR.
意大利心血管康复与预防协会(ITACARE-P)和意大利医院内科医生协会联合会(FADOI)发布了一份联合立场文件,旨在指导从内科(IM)病房出院的心血管病人转诊至心脏康复(CR)机构。该文件就适当性(即合格诊断)和优先标准提供了理论依据和操作建议,以克服 CR 项目潜在需求与有效供应之间的不匹配。在因后勤障碍而无法转诊的情况下,文件建议采用 CR 的最佳替代方案,以减少残疾、改善预后和提高生活质量。联合立场文件还旨在促进将 IM 视为 CR 的潜在利益攸关方。
{"title":"Position paper ITACARE-P/FADOI on the referral from internal medicine to cardiac rehabilitation: Executive summary and factsheet","authors":"Marco Ambrosetti , Francesco Fattirolli , Paola Gnerre , Franco Mastroianni , Gian Francesco Mureddu , Francesco Dentali , Francesco Giallauria , Michele Meschi , Alessandra Pratesi , Matteo Ruzzolini , Elio Venturini","doi":"10.1016/j.ijcrp.2024.200275","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200275","url":null,"abstract":"<div><p>The Italian Association for Cardiovascular Rehabilitation and Prevention (ITACARE-P) and the Italian Federation of Associations of Hospital Doctors on Internal Medicine (FADOI) released a joint position paper to guide referrals of cardiovascular patients discharged from Internal Medicine (IM) wards to Cardiac Rehabilitation (CR) facilities. The document provides rationale and operative recommendations for appropriateness (i.e. qualifying diagnoses) and priority criteria to overcome the mismatch between potential demand and effective supply of CR programmes. In case of no-referral due to logistic barriers, the document recommends the adoption of best alternatives to CR for disability reduction, better prognosis, and improvement of quality of life. The joint position paper is also aimed to promote the consideration of IM as a potential stakeholder of CR.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200275"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000400/pdfft?md5=547cac32d2f40a66c7d6662f3454beb0&pid=1-s2.0-S2772487524000400-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.ijcrp.2024.200268
Elisabetta Angelino
Women receive similar or greater benefits than men from Cardiac Rehabilitation (CR). However, they are less likely to participate. An integrated and gender-sensitive approach to cardiovascular disease is required to enhance the quality and experience of care for women with different cardiovascular issues throughout their lives.
The Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P) is committed to developing a gender-specific approach to CR that will more effectively meet the needs of both women and men.
{"title":"41Bridging the gender gap in Cardiac Rehabilitation. The first step: The equal opportunities project","authors":"Elisabetta Angelino","doi":"10.1016/j.ijcrp.2024.200268","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200268","url":null,"abstract":"<div><p>Women receive similar or greater benefits than men from Cardiac Rehabilitation (CR). However, they are less likely to participate. An integrated and gender-sensitive approach to cardiovascular disease is required to enhance the quality and experience of care for women with different cardiovascular issues throughout their lives.</p><p>The Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P) is committed to developing a gender-specific approach to CR that will more effectively meet the needs of both women and men.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200268"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000333/pdfft?md5=6cc1d0225a067fede5e8f931a690a21f&pid=1-s2.0-S2772487524000333-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.ijcrp.2024.200270
Letizia da Vico
Background
The prevalence and incidence of cardiovascular diseases significantly increase with age, and it is well-known that nutritional status affects the prognosis and treatment of these diseases. Therefore, evaluating nutritional status is essential for maintaining/regaining health. It is crucial to identify nutritional risk early, prevent and/or treat protein-energy malnutrition, and promote the modification of inappropriate dietary habits.
Methods
Nutritional screening represents the first step of access to the Nutrition Care Process (NCP) adopted and managed by the dietitian; this tool must be simple, inexpensive, accessible, accurate, efficient, and validated. A globally accepted standardized definition of malnutrition is necessary, and for this reason, the Global Leadership Initiative on Malnutrition (GLIM) criteria have been recently introduced.
The GLIM criteria, after confirming nutritional risk through screening, include both phenotypic and etiological criteria: to diagnose malnutrition, at least one of these must be present.
A less commonly performed phenotypic criterion is the assessment of muscle mass, which should be studied as a significant component of sarcopenia.
Conclusion
Greater attention to the identification and treatment of malnutrition would bring benefits to patients and ensure a saving in healthcare expenditure, but for this purpose, an implementation of clinical nutrition services is necessary.
{"title":"Indicators of nutritional status and patient needs in cardiac rehabilitation","authors":"Letizia da Vico","doi":"10.1016/j.ijcrp.2024.200270","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200270","url":null,"abstract":"<div><h3>Background</h3><p>The prevalence and incidence of cardiovascular diseases significantly increase with age, and it is well-known that nutritional status affects the prognosis and treatment of these diseases. Therefore, evaluating nutritional status is essential for maintaining/regaining health. It is crucial to identify nutritional risk early, prevent and/or treat protein-energy malnutrition, and promote the modification of inappropriate dietary habits.</p></div><div><h3>Methods</h3><p>Nutritional screening represents the first step of access to the Nutrition Care Process (NCP) adopted and managed by the dietitian; this tool must be simple, inexpensive, accessible, accurate, efficient, and validated. A globally accepted standardized definition of malnutrition is necessary, and for this reason, the Global Leadership Initiative on Malnutrition (GLIM) criteria have been recently introduced.</p><p>The GLIM criteria, after confirming nutritional risk through screening, include both phenotypic and etiological criteria: to diagnose malnutrition, at least one of these must be present.</p><p>A less commonly performed phenotypic criterion is the assessment of muscle mass, which should be studied as a significant component of sarcopenia.</p></div><div><h3>Conclusion</h3><p>Greater attention to the identification and treatment of malnutrition would bring benefits to patients and ensure a saving in healthcare expenditure, but for this purpose, an implementation of clinical nutrition services is necessary.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200270"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000357/pdfft?md5=9b643f5c811d8c8904d2450799e9d61a&pid=1-s2.0-S2772487524000357-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.ijcrp.2024.200271
Alessandro Maloberti , Claudio Ciampi , Francesco Politi , Saverio Fabbri , Francesco Musca , Cristina Giannattasio
Cardiac amyloidosis is becoming increasingly important among cardiologist and an early diagnosis is very important. Amyloidosis is a systemic disease and many cardiac and extracardiac elements (red flags) should raise the suspicion of the disease. Electrocardiographic and imaging techniques (such as echocardiography, cardiac magnetic resonance and scintigraphy) are useful tools to make a diagnosis together with the presence of orthopedic issues, peripheral neuropathy or plasma cell dyscrasia. Cardiac amyloidosis is also often associated with valvular disorder, heart failure or cardiomyopathy. Red flags are crucial to raise suspicion and reach an early diagnosis, in order to start a targeted treatment strategy that could change the patient's outcome. Indeed, in the last years four new drugs were approved to treat transthyretin amyloidosis.
{"title":"Cardiac amyloidosis red flags: What all the cardiologist have to know","authors":"Alessandro Maloberti , Claudio Ciampi , Francesco Politi , Saverio Fabbri , Francesco Musca , Cristina Giannattasio","doi":"10.1016/j.ijcrp.2024.200271","DOIUrl":"https://doi.org/10.1016/j.ijcrp.2024.200271","url":null,"abstract":"<div><p>Cardiac amyloidosis is becoming increasingly important among cardiologist and an early diagnosis is very important. Amyloidosis is a systemic disease and many cardiac and extracardiac elements (red flags) should raise the suspicion of the disease. Electrocardiographic and imaging techniques (such as echocardiography, cardiac magnetic resonance and scintigraphy) are useful tools to make a diagnosis together with the presence of orthopedic issues, peripheral neuropathy or plasma cell dyscrasia. Cardiac amyloidosis is also often associated with valvular disorder, heart failure or cardiomyopathy. Red flags are crucial to raise suspicion and reach an early diagnosis, in order to start a targeted treatment strategy that could change the patient's outcome. Indeed, in the last years four new drugs were approved to treat transthyretin amyloidosis.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200271"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000369/pdfft?md5=82695930583ce0e9b5824df165f8db8f&pid=1-s2.0-S2772487524000369-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141249846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.ijcrp.2024.200280
Zeeshan Afzal, Abdul Basit, Usama Habib, Mateen Aman, Muhammad Azim, Huili Cao
{"title":"Emerging risks of microplastics and nanoplastics (MNPs): Is a silent threat for cardiovascular disease?","authors":"Zeeshan Afzal, Abdul Basit, Usama Habib, Mateen Aman, Muhammad Azim, Huili Cao","doi":"10.1016/j.ijcrp.2024.200280","DOIUrl":"10.1016/j.ijcrp.2024.200280","url":null,"abstract":"","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"21 ","pages":"Article 200280"},"PeriodicalIF":2.3,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277248752400045X/pdfft?md5=a163542ae81fcc5ef1bc68ad77f4cfd5&pid=1-s2.0-S277248752400045X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141030184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}