International Journal of Cardiology Cardiovascular Risk and Prevention最新文献_第2页

Ketogenic diets are associated with an elevated risk of hypertension: Insights from a cross-sectional analysis of the NHANES 2007-2018. 生酮饮食与高血压风险升高有关：2007-2018年国家健康调查（NHANES）横断面分析的启示。

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Cardiology Cardiovascular Risk and Prevention

Pub Date : 2024-10-10 DOI: 10.1016/j.ijcrp.2024.200342

Xiaolong Qu , Yuping Liu , Lei Huang , Fang Wan

Background

The ketogenic diet (KD) is widely used for weight loss in obese individuals; however, its potential impact on hypertension risk remains uncertain.

Methods

We used cross-sectional data from the 2007-2018 to National Health and Nutrition Examination Survey (NHANES) to investigate the association between the dietary ketogenic ratio (DKR) and hypertension prevalence. Dietary intake information was obtained through a comprehensive 24-hour dietary recall interview. The DKR values were computed using a specialized formula. Multiple logistic regression analysis was employed to examine this association, whereas nonlinear relationships were assessed using restricted cubic splines. Inflection points were determined using two-piecewise linear regression analysis. Subgroup analyses based on age were also performed.

Results

In a fully adjusted multivariate logistic regression model accounting for confounding variables, DKR was significantly associated with hypertension (OR, 1.24; 95% CI: 1.00-1.53; P = 0.045). Moreover, individuals in the highest quartile of DKR exhibited a significantly elevated risk of hypertension compared with those in the lowest quartile (OR, 1.15; 95% CI: 1.07-1.24; P < 0.001). Additionally, restricted cubic spline analysis revealed a linear relationship between DKR and the risk of hypertension, with a turning point identified at 3.4 units on the measurement scale employed for this study's purposes. Subgroup analyses indicated that this association between DKR and hypertension was particularly pronounced among individuals aged ≥40 years, especially those age group–40-60.We further observed that a multivariate linear regression analysis revealed a significant positive correlation between DKR and DBP in a fully adjusted model(β, 0.42; 95% CI: 0.12-0.87; P = 0.018), indicating that as DKR increased, there was an accompanying increase in DBP. However, no significant correlation was found between SBP and DKR(β, 0.11; 95% CI: -0.37, 0.59; P = 0.655).

Conclusion

The KD may enhance susceptibility to hypertension in middle-aged and elderly populations in the United States, exhibiting a strong association with elevated diastolic blood pressure, while no significant correlation was observed with increased systolic blood pressure.

背景生酮饮食（KD）被广泛用于肥胖者的减肥；然而，它对高血压风险的潜在影响仍不确定。方法我们利用2007-2018年美国国家健康与营养调查（NHANES）的横断面数据，研究了膳食生酮比率（DKR）与高血压患病率之间的关系。膳食摄入信息是通过24小时膳食回忆综合访谈获得的。DKR 值使用专门公式计算。采用多元逻辑回归分析来检验这种关联，而非线性关系则使用限制性立方样条进行评估。拐点是通过两部分线性回归分析确定的。结果在考虑了混杂变量的完全调整多变量逻辑回归模型中，DKR 与高血压显著相关（OR，1.24；95% CI：1.00-1.53；P = 0.045）。此外，与最低四分位数的人相比，DKR最高四分位数的人患高血压的风险明显升高（OR，1.15；95% CI：1.07-1.24；P <0.001）。此外，限制性立方样条分析显示，DKR 与高血压风险之间存在线性关系，转折点在本研究采用的测量量表的 3.4 个单位处。亚组分析表明，DKR 与高血压之间的这种关联在年龄≥40 岁的人群中尤为明显，尤其是 40-60 岁年龄组的人群。我们进一步观察到，多变量线性回归分析显示，在完全调整模型中，DKR 与 DBP 之间存在显著的正相关性（β，0.42；95% CI：0.12-0.87；P = 0.018），表明随着 DKR 的增加，DBP 也会随之增加。结论KD可能会增加美国中老年人群的高血压易感性，与舒张压升高密切相关，而与收缩压升高无明显相关性。

{"title":"Ketogenic diets are associated with an elevated risk of hypertension: Insights from a cross-sectional analysis of the NHANES 2007-2018.","authors":"Xiaolong Qu , Yuping Liu , Lei Huang , Fang Wan","doi":"10.1016/j.ijcrp.2024.200342","DOIUrl":"10.1016/j.ijcrp.2024.200342","url":null,"abstract":"<div><h3>Background</h3><div>The ketogenic diet (KD) is widely used for weight loss in obese individuals; however, its potential impact on hypertension risk remains uncertain.</div></div><div><h3>Methods</h3><div>We used cross-sectional data from the 2007-2018 to National Health and Nutrition Examination Survey (NHANES) to investigate the association between the dietary ketogenic ratio (DKR) and hypertension prevalence. Dietary intake information was obtained through a comprehensive 24-hour dietary recall interview. The DKR values were computed using a specialized formula. Multiple logistic regression analysis was employed to examine this association, whereas nonlinear relationships were assessed using restricted cubic splines. Inflection points were determined using two-piecewise linear regression analysis. Subgroup analyses based on age were also performed.</div></div><div><h3>Results</h3><div>In a fully adjusted multivariate logistic regression model accounting for confounding variables, DKR was significantly associated with hypertension (OR, 1.24; 95% CI: 1.00-1.53; P = 0.045). Moreover, individuals in the highest quartile of DKR exhibited a significantly elevated risk of hypertension compared with those in the lowest quartile (OR, 1.15; 95% CI: 1.07-1.24; P < 0.001). Additionally, restricted cubic spline analysis revealed a linear relationship between DKR and the risk of hypertension, with a turning point identified at 3.4 units on the measurement scale employed for this study's purposes. Subgroup analyses indicated that this association between DKR and hypertension was particularly pronounced among individuals aged ≥40 years, especially those age group–40-60.We further observed that a multivariate linear regression analysis revealed a significant positive correlation between DKR and DBP in a fully adjusted model(β, 0.42; 95% CI: 0.12-0.87; P = 0.018), indicating that as DKR increased, there was an accompanying increase in DBP. However, no significant correlation was found between SBP and DKR(β, 0.11; 95% CI: -0.37, 0.59; P = 0.655).</div></div><div><h3>Conclusion</h3><div>The KD may enhance susceptibility to hypertension in middle-aged and elderly populations in the United States, exhibiting a strong association with elevated diastolic blood pressure, while no significant correlation was observed with increased systolic blood pressure.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200342"},"PeriodicalIF":1.9,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetic cardiomyopathy: pathophysiology, imaging assessment and therapeutical strategies 糖尿病心肌病：病理生理学、成像评估和治疗策略

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Cardiology Cardiovascular Risk and Prevention

Pub Date : 2024-09-28 DOI: 10.1016/j.ijcrp.2024.200338

Vincenzo Rizza , Lara Tondi , Angelo Maria Patti , Damiano Cecchi , Massimo Lombardi , Francesco Perone , Marco Ambrosetti , Manfredi Rizzo , Domenico Cianflone , Francesco Maranta

Diabetes mellitus (DM) is one of the most prevalent cardiovascular risk factors in the general population, being associated with high morbidity and socioeconomic burden. Diabetic cardiomyopathy (DCM) is a non-negligible complication of DM, whose pathophysiological fundaments are the altered cardiac metabolism, the hyperglycemia-triggered formation of advanced glycation end-products (AGEs) and the inflammatory milieu which are typical in diabetic patients. These metabolic abnormalities lead to cardiomyocytes apoptosis, interstitial fibrosis and mechanical cardiac dysfunction, which can be identified with non-invasive imaging techniques, like echocardiography and cardiac magnetic resonance. This review aims to: 1) describe the major imaging features of DCM; 2) highlight how early identification of DCM-related anatomical and functional remodeling might allow patients’ therapy optimization and prognosis improvement.

糖尿病（DM）是普通人群中最常见的心血管风险因素之一，与高发病率和社会经济负担相关。糖尿病心肌病（DCM）是糖尿病的一种不可忽视的并发症，其病理生理基础是糖尿病患者典型的心脏代谢改变、高血糖引发的高级糖化终产物（AGEs）的形成和炎症环境。这些代谢异常会导致心肌细胞凋亡、间质纤维化和机械性心脏功能障碍，可通过超声心动图和心脏磁共振等非侵入性成像技术加以识别。本综述旨在1）描述 DCM 的主要成像特征；2）强调早期识别与 DCM 相关的解剖和功能重塑可如何帮助患者优化治疗和改善预后。

{"title":"Diabetic cardiomyopathy: pathophysiology, imaging assessment and therapeutical strategies","authors":"Vincenzo Rizza , Lara Tondi , Angelo Maria Patti , Damiano Cecchi , Massimo Lombardi , Francesco Perone , Marco Ambrosetti , Manfredi Rizzo , Domenico Cianflone , Francesco Maranta","doi":"10.1016/j.ijcrp.2024.200338","DOIUrl":"10.1016/j.ijcrp.2024.200338","url":null,"abstract":"<div><div>Diabetes mellitus (DM) is one of the most prevalent cardiovascular risk factors in the general population, being associated with high morbidity and socioeconomic burden. Diabetic cardiomyopathy (DCM) is a non-negligible complication of DM, whose pathophysiological fundaments are the altered cardiac metabolism, the hyperglycemia-triggered formation of advanced glycation end-products (AGEs) and the inflammatory milieu which are typical in diabetic patients. These metabolic abnormalities lead to cardiomyocytes apoptosis, interstitial fibrosis and mechanical cardiac dysfunction, which can be identified with non-invasive imaging techniques, like echocardiography and cardiac magnetic resonance. This review aims to: 1) describe the major imaging features of DCM; 2) highlight how early identification of DCM-related anatomical and functional remodeling might allow patients’ therapy optimization and prognosis improvement.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200338"},"PeriodicalIF":1.9,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

eGFRCystatin C, difference between eGFRCystatin C and eGFRCre and heart failure: Insight from the NHANES 2001–2002 and Mendelian randomization analysis eGFRCstyatin C、eGFRCstyatin C 和 eGFRCre 之间的差异以及心力衰竭：来自 2001-2002 年国家健康调查（NHANES）和孟德尔随机分析的启示

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Cardiology Cardiovascular Risk and Prevention

Pub Date : 2024-09-27 DOI: 10.1016/j.ijcrp.2024.200337

Zhiyu Gu , Rui Zhang , Weihong Chang , Hongxuan Fan , Zixuan Dou , Peng Liu , Aman Liu , Boda Zhou

Aim

Estimated glomerular filtration rate (eGFR) derived from Cystatin C (eGFR_{Cystatin C}), and the difference between Cystatin C and creatinine based eGFR (eGFR_diff) has been suggested to be associated with cardiovascular disease. However, the association between eGFR_{Cystatin C},eGFR_diff and heart failure (HF) risk has not been elucidated in a relatively healthy cohort.

Methods

We used cohort study data from the NHANES 2001–2002. Mendelian randomization (MR) study used GWAS data from 437,846 European participants. The exposures are eGFR_{Cystatin C} & eGFR_diff, outcome is self reported heart failure. Weighted multivariable-adjusted logistic regression and Kaplan-Meier survival analysis was used in corhort study. Inverse variance weighted (IVW) was applied in MR study.

Results

The cohort study included 2155 participants. Importantly, we simplified eGFR_diff classification into ≥0 and < 0, and found that eGFR_diff≥0 was associated with 52 % reduction of HF risk (OR 0.48, [95 % CI, 0.29–0.80], p = 0.005). We also found that 1 ml/min/1.73 m² of eGFR_{Cystatin C} had a significant negative association with HF after adjusting for covariates. Interestingly, we showed a non-linear association between eGFR_{Cystatin C} and HF, eGFR_diff and HF. In participants without know HF, during a median follow-up of 17.3 years, those in the low eGFR_{Cystatin C} or low eGFR_diff groups showed significantly poorer survival. Moreover, MR analysis found genetic predisposition to cystatin C was significantly associated with an increased risk of HF.

Conclusion

Both decreased eGFR_{Cystatin C} and eGFR_diff levels were associated with heart failure and poor survival, but the latter seems more obvious.

目的根据胱抑素 C 得出的估计肾小球滤过率（eGFR）（eGFRRCystatin C）以及胱抑素 C 和肌酐 eGFR 之间的差异（eGFRdiff）被认为与心血管疾病有关。然而，在一个相对健康的队列中，eGFRC胱抑素C、eGFRdiff与心力衰竭（HF）风险之间的关系尚未得到阐明。孟德尔随机化（MR）研究使用了 437 846 名欧洲参与者的 GWAS 数据。暴露因子为 eGFRC胱抑素 C & eGFRdiff，结果为自我报告的心力衰竭。在队列研究中使用了加权多变量调整逻辑回归和 Kaplan-Meier 生存分析。结果队列研究纳入了 2155 名参与者。重要的是，我们将 eGFRdiff 分类简化为≥0 和 <0，并发现 eGFRdiff≥0 与 52% 的 HF 风险降低相关（OR 0.48, [95 % CI, 0.29-0.80], p = 0.005）。我们还发现，在调整协变量后，1 ml/min/1.73 m2 的 eGFRCystatin C 与心房颤动有显著的负相关。有趣的是，我们发现 eGFRCystatin C 与 HF、eGFRdiff 与 HF 之间存在非线性关联。在中位随访 17.3 年的过程中，未发现患有高血压的参与者中，低 eGFRCystatin C 组或低 eGFRdiff 组的生存率明显较低。结论 eGFRCystatin C 和 eGFRdiff 水平的降低都与心衰和生存率低有关，但后者似乎更为明显。

{"title":"eGFRCystatin C, difference between eGFRCystatin C and eGFRCre and heart failure: Insight from the NHANES 2001–2002 and Mendelian randomization analysis","authors":"Zhiyu Gu , Rui Zhang , Weihong Chang , Hongxuan Fan , Zixuan Dou , Peng Liu , Aman Liu , Boda Zhou","doi":"10.1016/j.ijcrp.2024.200337","DOIUrl":"10.1016/j.ijcrp.2024.200337","url":null,"abstract":"<div><h3>Aim</h3><div>Estimated glomerular filtration rate (eGFR) derived from Cystatin C (eGFR<sub>Cystatin C</sub>), and the difference between Cystatin C and creatinine based eGFR (eGFR<sub>diff</sub>) has been suggested to be associated with cardiovascular disease. However, the association between eGFR<sub>Cystatin C</sub>,eGFR<sub>diff</sub> and heart failure (HF) risk has not been elucidated in a relatively healthy cohort.</div></div><div><h3>Methods</h3><div>We used cohort study data from the NHANES 2001–2002. Mendelian randomization (MR) study used GWAS data from 437,846 European participants. The exposures are eGFR<sub>Cystatin C</sub> & eGFR<sub>diff</sub>, outcome is self reported heart failure. Weighted multivariable-adjusted logistic regression and Kaplan-Meier survival analysis was used in corhort study. Inverse variance weighted (IVW) was applied in MR study.</div></div><div><h3>Results</h3><div>The cohort study included 2155 participants. Importantly, we simplified eGFR<sub>diff</sub> classification into ≥0 and < 0, and found that eGFR<sub>diff</sub>≥0 was associated with 52 % reduction of HF risk (OR 0.48, [95 % CI, 0.29–0.80], p = 0.005). We also found that 1 ml/min/1.73 m<sup>2</sup> of eGFR<sub>Cystatin C</sub> had a significant negative association with HF after adjusting for covariates. Interestingly, we showed a non-linear association between eGFR<sub>Cystatin C</sub> and HF, eGFR<sub>diff</sub> and HF. In participants without know HF, during a median follow-up of 17.3 years, those in the low eGFR<sub>Cystatin C</sub> or low eGFR<sub>diff</sub> groups showed significantly poorer survival. Moreover, MR analysis found genetic predisposition to cystatin C was significantly associated with an increased risk of HF.</div></div><div><h3>Conclusion</h3><div>Both decreased eGFR<sub>Cystatin C</sub> and eGFR<sub>diff</sub> levels were associated with heart failure and poor survival, but the latter seems more obvious.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200337"},"PeriodicalIF":1.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142423011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of smoking on procedural outcomes and all-cause mortality following acute myocardial infarction: A misleading early-stage pseudoparadox with ultimately reduced survival 吸烟对急性心肌梗死术后结果和全因死亡率的影响：误导早期假性心肌梗死，最终降低存活率

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Cardiology Cardiovascular Risk and Prevention

Pub Date : 2024-09-27 DOI: 10.1016/j.ijcrp.2024.200336

Mohammed Abusharekh, Jürgen Kampf, Iryna Dykun, Viktoria Backmann, Rolf Alexander Jánosi, Matthias Totzeck, Tienush Rassaf, Amir Abbas Mahabadi

Background

Smoking has conflicting results on outcomes following acute myocardial infarction (AMI). We evaluated the independent influence of smoking status on patient outcomes.

Methods

We included patients with AMI undergoing invasive coronary angiography with available self-reported smoking status. The incidence of death of any cause was evaluated during a median follow-up of 1.14 years (range 0.36–3.40 years). Association between smoking status and long-term mortality was evaluated using multivariable adjusted Cox regression analysis.

Results

From 1612 AMI patients (aged 65.7 ± 13.3 years, 72.1 % male), 378 patients (23.4 %) were current-smokers, 311 (19.3 %) ex-smokers, and 923 (57.3 %) non-smokers. Compared with non-smokers, current-smokers were younger (68.5 ± 13.0 vs. 58.6 ± 12.5, p < 0.0001) and more frequently presented with STEMI (21.6 % vs. 35,4 %, p < 0.0001), while ex-smokers with similar frequency of STEMI-manifestation as non-smokers (22.5 %, p = 0.79) constituted an intermediate-group in terms of age (65.8 ± 11,6 years). Although smoking status was not significantly associated with long-term survival in unadjusted-analysis, active-smokers had 56 % higher long-term mortality than non-smokers when adjusting for age, gender, medications and other traditional risk factors, whereas ex-smokers possessed comparable survival probability (current-smokers: 1.56[1.14–2.14], p = 0.006, ex-smokers 1.16[0.84–1.59], p = 0.37). Current-smokers had unadjusted lower NT-proBNP and modestly higher absolute in-hospital left ventricular global longitudinal strain (LV GLS) values that did not differ among groups after the same adjustments (NT-proBNP: −0.08[-0.31; 0.15], p = 0.5, LV GLS: 0.65[-0.26; 1.55], p = 0.16).

Conclusion

Active smoking is associated with increased adjusted long-term mortality, earlier onset and more frequent manifestation as STEMI, compared to non-smoking. Comparable adjusted results for LV GLS and NT-proBNP between groups support the presence of the pseudoparadox.

背景吸烟对急性心肌梗死（AMI）后的预后有着相互矛盾的结果。我们评估了吸烟状况对患者预后的独立影响。方法我们纳入了接受有创冠状动脉造影术并能自我报告吸烟状况的急性心肌梗死患者。在中位 1.14 年（0.36-3.40 年）的随访期间，我们评估了各种原因导致的死亡发生率。结果在 1612 名 AMI 患者（年龄为 65.7 ± 13.3 岁，72.1% 为男性）中，有 378 名患者（23.4%）目前吸烟，311 名患者（19.3%）曾经吸烟，923 名患者（57.3%）不吸烟。与非吸烟者相比，当前吸烟者更年轻（68.5 ± 13.0 vs. 58.6 ± 12.5，p < 0.0001），更经常出现 STEMI（21.6 % vs. 35.4 %，p < 0.0001），而曾经吸烟者的 STEMI 发生率与非吸烟者相似（22.5 %，p = 0.79），在年龄上属于中间组（65.8 ± 11.6 岁）。虽然在未经调整的分析中，吸烟状况与长期生存率并无明显关联，但在对年龄、性别、药物和其他传统风险因素进行调整后，主动吸烟者的长期死亡率比不吸烟者高出 56%，而戒烟者的生存概率与主动吸烟者相当（当前吸烟者：1.56[1.14-2.00]）：1.56[1.14-2.14]，p = 0.006；戒烟者 1.16[0.84-1.59]，p = 0.37）。目前吸烟者未经调整的NT-proBNP值较低，院内左心室整体纵向应变（LV GLS）绝对值略高，经同样调整后，各组间无差异（NT-proBNP：-0.08[-0.31; 0.15]，p = 0.5，LV GLS：0.65[-0.26; 1.55]，p = 0.16）。各组间 LV GLS 和 NT-proBNP 的调整结果相当，这支持了假性动脉粥样硬化的存在。

{"title":"Impact of smoking on procedural outcomes and all-cause mortality following acute myocardial infarction: A misleading early-stage pseudoparadox with ultimately reduced survival","authors":"Mohammed Abusharekh, Jürgen Kampf, Iryna Dykun, Viktoria Backmann, Rolf Alexander Jánosi, Matthias Totzeck, Tienush Rassaf, Amir Abbas Mahabadi","doi":"10.1016/j.ijcrp.2024.200336","DOIUrl":"10.1016/j.ijcrp.2024.200336","url":null,"abstract":"<div><h3>Background</h3><div>Smoking has conflicting results on outcomes following acute myocardial infarction (AMI). We evaluated the independent influence of smoking status on patient outcomes.</div></div><div><h3>Methods</h3><div>We included patients with AMI undergoing invasive coronary angiography with available self-reported smoking status. The incidence of death of any cause was evaluated during a median follow-up of 1.14 years (range 0.36–3.40 years). Association between smoking status and long-term mortality was evaluated using multivariable adjusted Cox regression analysis.</div></div><div><h3>Results</h3><div>From 1612 AMI patients (aged 65.7 ± 13.3 years, 72.1 % male), 378 patients (23.4 %) were current-smokers, 311 (19.3 %) ex-smokers, and 923 (57.3 %) non-smokers. Compared with non-smokers, current-smokers were younger (68.5 ± 13.0 vs. 58.6 ± 12.5, p < 0.0001) and more frequently presented with STEMI (21.6 % vs. 35,4 %, p < 0.0001), while ex-smokers with similar frequency of STEMI-manifestation as non-smokers (22.5 %, p = 0.79) constituted an intermediate-group in terms of age (65.8 ± 11,6 years). Although smoking status was not significantly associated with long-term survival in unadjusted-analysis, active-smokers had 56 % higher long-term mortality than non-smokers when adjusting for age, gender, medications and other traditional risk factors, whereas ex-smokers possessed comparable survival probability (current-smokers: 1.56[1.14–2.14], p = 0.006, ex-smokers 1.16[0.84–1.59], p = 0.37). Current-smokers had unadjusted lower NT-proBNP and modestly higher absolute in-hospital left ventricular global longitudinal strain (LV GLS) values that did not differ among groups after the same adjustments (NT-proBNP: −0.08[-0.31; 0.15], p = 0.5, LV GLS: 0.65[-0.26; 1.55], p = 0.16).</div></div><div><h3>Conclusion</h3><div>Active smoking is associated with increased adjusted long-term mortality, earlier onset and more frequent manifestation as STEMI, compared to non-smoking. Comparable adjusted results for LV GLS and NT-proBNP between groups support the presence of the pseudoparadox.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200336"},"PeriodicalIF":1.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of cardiovascular risk in patients with ANCA-associated vasculitis: A systematic review and meta-analysis ANCA 相关性血管炎患者的心血管风险评估：系统回顾和荟萃分析

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Cardiology Cardiovascular Risk and Prevention

Pub Date : 2024-09-25 DOI: 10.1016/j.ijcrp.2024.200334

Aman Goyal , Haleema Qayyum Abbasi , Yusra Mashkoor , Abdul Moiz Khan , Samia Aziz Sulaiman , Mohamed Daoud , Kamna Bansal

Background

Although many chronic inflammatory conditions are linked to elevated cardiovascular risk, the specific extent of this risk in ANCA-associated vasculitis (AAV) remains elusive, largely due to the disease's rarity. Our study sought to clarify the cardiovascular risks and mortality linked to AAV.

Methods

A systematic literature review was conducted across multiple databases from their inception until April 2024 to identify studies comparing cardiovascular outcomes in patients with and without AAV. R Studio's meta package was used to pool risk ratios under the random-effects model, and statistical significance was set at p < 0.05.

Results

Nine observational studies involving 45024 individuals were included in this analysis. Patients with AAV exhibited a significantly elevated risk of stroke (RR = 1.43, 95 % CI: 1.12–1.83, I2 = 62 %, p = 0.0048), myocardial infarction (RR = 1.49, 95 % CI: 1.25–1.79, I² = 0 %, p < 0.0001), ischemic heart disease (RR = 1.40, 95 % CI: 1.24–1.58, I² = 1 %, p < 0.0001), venous thromboembolism (RR = 2.57, 95 % CI: 1.70–3.90, I² = 74 %, p < 0.0001), and pulmonary embolism (RR = 3.53, 95 % CI: 2.82–4.42, I² = 9 %, p < 0.0001), deep vein thrombosis (RR: 4.21; 95 % CI: 2.00–8.86; p = 0.0002), heart failure (RR = 1.63, 95 % CI: 1.39–1.90, I² = 0 %, p < 0.0001), and cardiovascular disease-related mortality (RR = 1.79, 95 % CI: 1.07–3.00, I2 = 0 %, p = 0.0256) compared to patients without AAV.

Conclusion

This meta-analysis underscores a notable increase in adverse cardiovascular events among patients with AAV, underscoring the need for comprehensive cardiovascular care and diligent monitoring in this patient cohort.

背景虽然许多慢性炎症都与心血管风险升高有关，但ANCA相关性血管炎（AAV）的这种风险的具体程度仍然难以确定，这主要是由于该疾病的罕见性。我们的研究旨在阐明与AAV相关的心血管风险和死亡率。方法我们对多个数据库进行了系统性文献综述，从数据库建立之初一直到2024年4月，以确定比较AAV患者和非AAV患者心血管结局的研究。结果本次分析纳入了九项观察性研究，涉及 45024 人。AAV 患者中风（RR = 1.43，95 % CI：1.12-1.83，I2 = 62 %，p = 0.0048）、心肌梗死（RR = 1.49，95 % CI：1.25-1.79，I2 = 0 %，p <0.0001）、缺血性心脏病（RR = 1.40，95 % CI：1.24-1.58，I2 = 1 %，p <；0.0001）、静脉血栓栓塞（RR = 2.57，95 % CI：1.70-3.90，I2 = 74 %，p <；0.0001）和肺栓塞（RR = 3.53，95 % CI：2.82-4.42，I2 = 9 %，p <；0.0001）、深静脉血栓（RR：4.21; 95 % CI: 2.00-8.86; p = 0.0002）、心力衰竭（RR = 1.63, 95 % CI: 1.39-1.90, I2 = 0 %, p < 0.0001）和心血管疾病相关死亡率（RR = 1.79, 95 % CI: 1.07-3.00, I2 = 0 %, p = 0.0256）。结论这项荟萃分析强调，AAV 患者的不良心血管事件明显增加，因此需要对这一患者群体进行全面的心血管护理和严密监测。

{"title":"Assessment of cardiovascular risk in patients with ANCA-associated vasculitis: A systematic review and meta-analysis","authors":"Aman Goyal , Haleema Qayyum Abbasi , Yusra Mashkoor , Abdul Moiz Khan , Samia Aziz Sulaiman , Mohamed Daoud , Kamna Bansal","doi":"10.1016/j.ijcrp.2024.200334","DOIUrl":"10.1016/j.ijcrp.2024.200334","url":null,"abstract":"<div><h3>Background</h3><div>Although many chronic inflammatory conditions are linked to elevated cardiovascular risk, the specific extent of this risk in ANCA-associated vasculitis (AAV) remains elusive, largely due to the disease's rarity. Our study sought to clarify the cardiovascular risks and mortality linked to AAV.</div></div><div><h3>Methods</h3><div>A systematic literature review was conducted across multiple databases from their inception until April 2024 to identify studies comparing cardiovascular outcomes in patients with and without AAV. R Studio's meta package was used to pool risk ratios under the random-effects model, and statistical significance was set at p < 0.05.</div></div><div><h3>Results</h3><div>Nine observational studies involving 45024 individuals were included in this analysis. Patients with AAV exhibited a significantly elevated risk of stroke (RR = 1.43, 95 % CI: 1.12–1.83, I2 = 62 %, p = 0.0048), myocardial infarction (RR = 1.49, 95 % CI: 1.25–1.79, <em>I</em><sup><em>2</em></sup> = 0 %, p < 0.0001), ischemic heart disease (RR = 1.40, 95 % CI: 1.24–1.58, <em>I</em><sup><em>2</em></sup> = 1 %, p < 0.0001), venous thromboembolism (RR = 2.57, 95 % CI: 1.70–3.90, <em>I</em><sup><em>2</em></sup> = 74 %, p < 0.0001), and pulmonary embolism (RR = 3.53, 95 % CI: 2.82–4.42, <em>I</em><sup><em>2</em></sup> = 9 %, p < 0.0001), deep vein thrombosis (RR: 4.21; 95 % CI: 2.00–8.86; p = 0.0002), heart failure (RR = 1.63, 95 % CI: 1.39–1.90, <em>I</em><sup><em>2</em></sup> = 0 %, p < 0.0001), and cardiovascular disease-related mortality (RR = 1.79, 95 % CI: 1.07–3.00, I2 = 0 %, p = 0.0256) compared to patients without AAV.</div></div><div><h3>Conclusion</h3><div>This meta-analysis underscores a notable increase in adverse cardiovascular events among patients with AAV, underscoring the need for comprehensive cardiovascular care and diligent monitoring in this patient cohort.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200334"},"PeriodicalIF":1.9,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142357173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovation, simplification, and adherence to real life, 2024 ESC guidelines of elevated blood pressure and hypertension claimed for 创新、简化和坚持现实生活中的 2024 年 ESC 血压升高和高血压指南称

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Cardiology Cardiovascular Risk and Prevention

Pub Date : 2024-09-19 DOI: 10.1016/j.ijcrp.2024.200335

Marco Ambrosetti, Monica Loguercio, Luigi Maresca, Chiara Meloni, Daniela Zaniboni

引用次数: 0

Association of classic cardiovascular risk factors with myocardial infarction and ischemic stroke: A cross sectional analysis of the Shiraz Heart Study 典型心血管风险因素与心肌梗死和缺血性中风的关系：设拉子心脏研究的横断面分析

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Cardiology Cardiovascular Risk and Prevention

Pub Date : 2024-09-11 DOI: 10.1016/j.ijcrp.2024.200332

Haleh Ghaem , Mohammad Javad Zibaeenezhad , Mehrab Sayadi , Sheida Khosravaniardakani , Nader Parsa , Iman Razeghian-Jahromi

Background

Myocardial infarction (MI) and ischemic stroke are the leading deadly clinical outcomes globally. This study aimed to investigate the association of classic cardiovascular risk factors with MI and ischemic stroke in a general population.

Methods

This cross-sectional study used the baseline data of the Shiraz Heart Study, a prospective cohort that investigate risk factors of coronary heart disease in a general population of Iran. Middle-aged citizens of 40–70 years old were included. Univariable and multivariable logistic regression analysis was performed to explore the association between sociodemographic, clinical, and metabolic factors and prevalent MI and stroke.

Results

Out of 7225 adults, 1.9 % (n = 135) had prior MI or stroke. Multiple logistic regression revealed that age≥60 years (aOR: 2.22, 95 % CI 1.45–3.20; P < 0.001), male sex (aOR: 3.82, 95 % CI 2.56–5.71; P < 0.001), history of hypertension (aOR: 1.71, 95 % CI 1.18–2.50; P < 0.005), history of hyperlipidemia (aOR: 2.42, 95 % CI 1.68–3.48; P < 0.001), having four 1st degree family members with sudden cardiac death (aOR: 26.28, 95 % CI 0.59–432.09; P < 0.022), and having a 1st degree family member with history of cardiovascular disease (aOR: 1.69, 95 % CI 1.13–2.54; P < 0.001) were associated with prior MI and stroke. Unlike high-density lipoprotein (P = 0.723) and triglyceride (P = 0.643), there were significant differences in the levels of fasting blood sugar (P < 0.001), total cholesterol (P < 0.001), and low-density lipoprotein (P < 0.001) between those with and without history of MI/stroke.

Conclusions

Being aged ≥60 years, history of hypertension and hyperlipidemia along with familial history of CVD and sudden cardiac death were in association with MI and stroke.

背景心肌梗死（MI）和缺血性中风是全球主要的致命性临床后果。本研究旨在调查普通人群中典型心血管风险因素与心肌梗死和缺血性中风之间的关系。方法这项横断面研究使用了设拉子心脏研究的基线数据，该研究是一项前瞻性队列研究，旨在调查伊朗普通人群中冠心病的风险因素。研究对象包括 40-70 岁的中年人。结果在 7225 名成年人中，1.9%（n = 135）曾有过心肌梗死或中风。48；P <；0.001）、家族中有四名一级成员患有心脏性猝死（aOR：26.28，95 % CI 0.59-432.09；P <；0.022）以及家族中有一名一级成员患有心血管疾病（aOR：1.69，95 % CI 1.13-2.54；P <；0.001）与既往心肌梗死和脑卒中相关。与高密度脂蛋白（P = 0.723）和甘油三酯（P = 0.643）不同，空腹血糖（P < 0.001）、总胆固醇（P < 0.001）和低密度脂蛋白（P < 0.结论年龄≥60 岁、有高血压和高脂血症史以及家族心血管疾病史和心脏性猝死史与心肌梗死和脑卒中有关。

{"title":"Association of classic cardiovascular risk factors with myocardial infarction and ischemic stroke: A cross sectional analysis of the Shiraz Heart Study","authors":"Haleh Ghaem , Mohammad Javad Zibaeenezhad , Mehrab Sayadi , Sheida Khosravaniardakani , Nader Parsa , Iman Razeghian-Jahromi","doi":"10.1016/j.ijcrp.2024.200332","DOIUrl":"10.1016/j.ijcrp.2024.200332","url":null,"abstract":"<div><h3>Background</h3><p>Myocardial infarction (MI) and ischemic stroke are the leading deadly clinical outcomes globally. This study aimed to investigate the association of classic cardiovascular risk factors with MI and ischemic stroke in a general population.</p></div><div><h3>Methods</h3><p>This cross-sectional study used the baseline data of the Shiraz Heart Study, a prospective cohort that investigate risk factors of coronary heart disease in a general population of Iran. Middle-aged citizens of 40–70 years old were included. Univariable and multivariable logistic regression analysis was performed to explore the association between sociodemographic, clinical, and metabolic factors and prevalent MI and stroke.</p></div><div><h3>Results</h3><p>Out of 7225 adults, 1.9 % (n = 135) had prior MI or stroke. Multiple logistic regression revealed that age≥60 years (aOR: 2.22, 95 % CI 1.45–3.20; <em>P</em> < 0.001), male sex (aOR: 3.82, 95 % CI 2.56–5.71; <em>P</em> < 0.001), history of hypertension (aOR: 1.71, 95 % CI 1.18–2.50; <em>P</em> < 0.005), history of hyperlipidemia (aOR: 2.42, 95 % CI 1.68–3.48; <em>P</em> < 0.001), having four 1st degree family members with sudden cardiac death (aOR: 26.28, 95 % CI 0.59–432.09; <em>P</em> < 0.022), and having a 1st degree family member with history of cardiovascular disease (aOR: 1.69, 95 % CI 1.13–2.54; <em>P</em> < 0.001) were associated with prior MI and stroke. Unlike high-density lipoprotein (<em>P</em> = 0.723) and triglyceride (<em>P</em> = 0.643), there were significant differences in the levels of fasting blood sugar (<em>P</em> < 0.001), total cholesterol (<em>P</em> < 0.001), and low-density lipoprotein (<em>P</em> < 0.001) between those with and without history of MI/stroke.</p></div><div><h3>Conclusions</h3><p>Being aged ≥60 years, history of hypertension and hyperlipidemia along with familial history of CVD and sudden cardiac death were in association with MI and stroke.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200332"},"PeriodicalIF":1.9,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000977/pdfft?md5=e3712ad5fc4d79dee43ea651bcfea682&pid=1-s2.0-S2772487524000977-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142243206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge and self-care practice among patients with hypertension in tertiary public hospitals of Addis Ababa, Ethiopia: A multicenter cross-sectional study 埃塞俄比亚亚的斯亚贝巴三级公立医院高血压患者的知识和自我护理实践：多中心横断面研究

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Cardiology Cardiovascular Risk and Prevention

Pub Date : 2024-09-11 DOI: 10.1016/j.ijcrp.2024.200333

Freweini Gebremeskel Gebresilase , Yohannes Ayalew Bekele , Ketema Bizuwork Gebremedhin , Boka Dugassa Tolera

Introduction

Globally, hypertension is the leading cause of death due to its related complications. Patients’ knowledge and self-care practice in hypertension is crucial for achieving optimal blood pressure control and prevention of related complications. This study aimed to evaluate the level of knowledge and self-care practice among hypertensive patients in Addis Ababa, Ethiopia.

Methods

A facility-based cross-sectional study was conducted among 413 hypertensive patients using simple random sampling methods. A face-to-face interview was administered using a structured questionnaire. Data was analyzed using SPSS version 27.0. Frequency percentage, and mean were calculated. Multivariable logistic regression was used to identify the association between predictors and outcome variables.

Results

Out of 413 respondents, 46.0 % (95 % CI: 40–50 %) and 40.9 % (95 % CI: 36–46 %) had poor knowledge and self-care practice respectively. Being married (AOR = 1.92, 95 % CI:1.19–3.06, P = 0.007), higher education [AOR = 7.38 (95 % CI: 2.29–23.78), P < 0.001); family history (AOR = 3.68, 95 % CI: 2.28–5.94, P < 0.001); getting information from healthcare providers (AOR = 3.17, 95 % CI: 1.46–6.87, P = 0.003) were significantly associated with knowledge of hypertension. Being female (AOR: 0.62,95 % CI: 0.39–0.97, P = 0.033), owing sphygmomanometer (AOR: 4.41,95 % CI: 2.40–8.13, P < 0.001) were associated with self-care practice towards hypertension.

Conclusion

The overall knowledge and self-care practice of respondents was low. Gender, marital status, educational level, family history, source of information, and owing sphygmomanometer were determinant factors. Improving patients’ awareness and self-care practice is essential for prevention and control of hypertension.

导言在全球范围内，高血压是因其相关并发症而导致死亡的主要原因。高血压患者的知识水平和自我保健实践对于实现最佳血压控制和预防相关并发症至关重要。本研究旨在评估埃塞俄比亚亚的斯亚贝巴高血压患者的高血压知识水平和自我护理方法。方法：采用简单随机抽样方法，对 413 名高血压患者进行了基于医疗机构的横断面研究。采用结构化问卷对患者进行了面对面访谈。数据使用 SPSS 27.0 版进行分析。计算了频率百分比和平均值。结果在 413 名受访者中，分别有 46.0 %（95 % CI：40-50 %）和 40.9 %（95 % CI：36-46 %）的受访者对高血压知识和自我保健实践知之甚少。已婚（AOR = 1.92，95 % CI：1.19-3.06，P = 0.007）、高学历[AOR = 7.38（95 % CI：2.29-23.78），P < 0.001]、家族史（AOR = 3.68，95 % CI：2.28-5.94，P < 0.001）、从医疗保健提供者处获得信息（AOR = 3.17，95 % CI：1.46-6.87，P = 0.003）与高血压知识显著相关。女性（AOR：0.62，95 % CI：0.39-0.97，P = 0.033）、拥有血压计（AOR：4.41，95 % CI：2.40-8.13，P <0.001）与高血压自我保健实践相关。性别、婚姻状况、教育程度、家族史、信息来源和拥有血压计是决定因素。提高患者对高血压的认识和自我保健意识对于预防和控制高血压至关重要。

{"title":"Knowledge and self-care practice among patients with hypertension in tertiary public hospitals of Addis Ababa, Ethiopia: A multicenter cross-sectional study","authors":"Freweini Gebremeskel Gebresilase , Yohannes Ayalew Bekele , Ketema Bizuwork Gebremedhin , Boka Dugassa Tolera","doi":"10.1016/j.ijcrp.2024.200333","DOIUrl":"10.1016/j.ijcrp.2024.200333","url":null,"abstract":"<div><h3>Introduction</h3><p>Globally, hypertension is the leading cause of death due to its related complications. Patients’ knowledge and self-care practice in hypertension is crucial for achieving optimal blood pressure control and prevention of related complications. This study aimed to evaluate the level of knowledge and self-care practice among hypertensive patients in Addis Ababa, Ethiopia.</p></div><div><h3>Methods</h3><p>A facility-based cross-sectional study was conducted among 413 hypertensive patients using simple random sampling methods. A face-to-face interview was administered using a structured questionnaire. Data was analyzed using SPSS version 27.0. Frequency percentage, and mean were calculated. Multivariable logistic regression was used to identify the association between predictors and outcome variables.</p></div><div><h3>Results</h3><p>Out of 413 respondents, 46.0 % (95 % CI: 40–50 %) and 40.9 % (95 % CI: 36–46 %) had poor knowledge and self-care practice respectively. Being married (AOR = 1.92, 95 % CI:1.19–3.06, <em>P</em> = 0.007)<strong>,</strong> higher education [AOR = 7.38 (95 % CI: 2.29–23.78), <em>P</em> < 0.001); family history (AOR = 3.68, 95 % CI: 2.28–5.94, <em>P</em> < 0.001); getting information from healthcare providers (AOR = 3.17, 95 % CI: 1.46–6.87, <em>P</em> = 0.003) were significantly associated with knowledge of hypertension. Being female (AOR: 0.62,95 % CI: 0.39–0.97, <em>P</em> = 0.033), owing sphygmomanometer (AOR: 4.41,95 % CI: 2.40–8.13, <em>P</em> < 0.001) were associated with self-care practice towards hypertension.</p></div><div><h3>Conclusion</h3><p>The overall knowledge and self-care practice of respondents was low. Gender, marital status, educational level, family history, source of information, and owing sphygmomanometer were determinant factors. Improving patients’ awareness and self-care practice is essential for prevention and control of hypertension.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200333"},"PeriodicalIF":1.9,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000989/pdfft?md5=45f49b5a559913a46316cd5df76792bf&pid=1-s2.0-S2772487524000989-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142172099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity and cardiovascular disease: Risk assessment, physical activity, and management of complications 肥胖与心血管疾病：风险评估、体育锻炼和并发症管理

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Cardiology Cardiovascular Risk and Prevention

Pub Date : 2024-09-05 DOI: 10.1016/j.ijcrp.2024.200331

Francesco Perone , Luigi Spadafora , Alessandra Pratesi , Giulia Nicolaio , Barbara Pala , Giulia Franco , Matteo Ruzzolini , Marco Ambrosetti

The patient with obesity is at risk of developing cardiovascular disease and risk factors. Obesity negatively impacts prognosis and increases cardiovascular morbidity and mortality. Therefore, a comprehensive risk assessment is needed to define the cardiovascular risk of the patient and, thus, a tailored management and treatment. Chronic and successful management of these patients involves the evaluation of the various therapeutic strategies available (comprehensive lifestyle intervention, weight-loss medications, and bariatric surgery) and the diagnosis and treatment of cardiovascular complications (coronary artery disease, heart failure, and atrial fibrillation). Cardiac rehabilitation in patients with obesity is showing beneficial effect and a positive impact on weight loss, cardiovascular risk factors, mental health, functional capacity, and adherence to lifestyle interventions and pharmacological treatment. Long-term weight loss and maintenance represent a key objective during the management of the patient with obesity to reduce the risk of future adverse events. Multidisciplinary management and interventions are necessary to prevent and reduce overall cardiovascular risk and mortality. The aim of our review is to propose a comprehensive, critical and updated overview regarding risk assessment, physical activity, and the management of cardiovascular complications in patient with obesity.

肥胖症患者面临罹患心血管疾病的风险和危险因素。肥胖会对预后产生负面影响，增加心血管疾病的发病率和死亡率。因此，需要进行全面的风险评估，以确定患者的心血管风险，从而进行有针对性的管理和治疗。对这些患者进行长期和成功的管理，包括评估现有的各种治疗策略（综合生活方式干预、减肥药物和减肥手术），以及诊断和治疗心血管并发症（冠状动脉疾病、心力衰竭和心房颤动）。肥胖症患者的心脏康复治疗对体重减轻、心血管风险因素、心理健康、功能能力以及生活方式干预和药物治疗的依从性都有好处和积极影响。在肥胖症患者的管理过程中，长期减轻和维持体重是降低未来不良事件风险的关键目标。多学科管理和干预对于预防和降低整体心血管风险和死亡率十分必要。我们的综述旨在就肥胖症患者的风险评估、体力活动和心血管并发症的管理提出全面、严谨和最新的概述。

{"title":"Obesity and cardiovascular disease: Risk assessment, physical activity, and management of complications","authors":"Francesco Perone , Luigi Spadafora , Alessandra Pratesi , Giulia Nicolaio , Barbara Pala , Giulia Franco , Matteo Ruzzolini , Marco Ambrosetti","doi":"10.1016/j.ijcrp.2024.200331","DOIUrl":"10.1016/j.ijcrp.2024.200331","url":null,"abstract":"<div><div>The patient with obesity is at risk of developing cardiovascular disease and risk factors. Obesity negatively impacts prognosis and increases cardiovascular morbidity and mortality. Therefore, a comprehensive risk assessment is needed to define the cardiovascular risk of the patient and, thus, a tailored management and treatment. Chronic and successful management of these patients involves the evaluation of the various therapeutic strategies available (comprehensive lifestyle intervention, weight-loss medications, and bariatric surgery) and the diagnosis and treatment of cardiovascular complications (coronary artery disease, heart failure, and atrial fibrillation). Cardiac rehabilitation in patients with obesity is showing beneficial effect and a positive impact on weight loss, cardiovascular risk factors, mental health, functional capacity, and adherence to lifestyle interventions and pharmacological treatment. Long-term weight loss and maintenance represent a key objective during the management of the patient with obesity to reduce the risk of future adverse events. Multidisciplinary management and interventions are necessary to prevent and reduce overall cardiovascular risk and mortality. The aim of our review is to propose a comprehensive, critical and updated overview regarding risk assessment, physical activity, and the management of cardiovascular complications in patient with obesity.</div></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200331"},"PeriodicalIF":1.9,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000965/pdfft?md5=be3ecb5e960d2c23df0809815eba6c34&pid=1-s2.0-S2772487524000965-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142311431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between grip strength, walking pace and incident peripheral artery disease: A prospective study of 430,886 UK biobank participants 握力、步行速度与外周动脉疾病之间的关系：对 430886 名英国生物库参与者的前瞻性研究

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Cardiology Cardiovascular Risk and Prevention

Pub Date : 2024-09-02 DOI: 10.1016/j.ijcrp.2024.200330

Duqiu Liu , Chenxing Yang , Gang Liu , Tianyu Guo , Sen Liu , Yi Guo , Jinjie Xiong , Ru Chen , Shan Deng

Background and aims

Patients with peripheral artery disease (PAD) presented overall muscle weakness and reduced physical performance. Previous study focused on the impact of muscle weakness on outcomes of established PAD, however the relationship between compromised muscle function and incident PAD remained unclear.

Methods

A prospective study involving 430,886 participants aged 40–69 y from UK biobank was conducted. The main outcome was incident PAD. Grip strength and walking pace were used as indicators for muscle function. Grip strength was measured using a Jamar J00105 hydraulic hand dynamometer, while walking pace was self-reported by the participants. Cox proportional hazard models were employed to investigate the relationship between grip strength, walking pace, and incident PAD.

Results

A total of 430,886 individuals were included in the final analysis. The mean age of the participants were 56.44 years, and 55.3 % were female. Over a median follow-up period of 13.81 years, 5,661 participants developed PAD. Higher grip strength, whether absolute or relative, exhibited a dose-dependent inverse association with incident PAD. Each 1 kg increment in absolute grip strength and each 0.01 kg/kg increase in relative grip strength were associated with reduced PAD risk by 2 % (HR: 0.98; 95 % CI [0.97–0.98]) and 83 % (HR: 0.17; 95 % CI [0.13–0.23]), respectively. Slow walking pace significantly correlated with increased PAD risk, while brisk walking pace was associated with decreased PAD risk.

Conclusion

Absolute grip strength, relative grip strength and walking pace were inversely associated with the risk of incident PAD.

背景和目的外周动脉疾病（PAD）患者会出现整体肌肉无力和体能下降的症状。以前的研究主要关注肌无力对已确诊的 PAD 结果的影响，但肌肉功能受损与事件性 PAD 之间的关系仍不清楚。主要结果是发生 PAD。握力和步行速度被用作肌肉功能的指标。握力使用Jamar J00105液压手部测力计测量，步行速度则由参与者自我报告。结果共有 430886 人被纳入最终分析。参与者的平均年龄为 56.44 岁，55.3% 为女性。在 13.81 年的中位随访期内，5661 名参与者出现了 PAD。较高的握力（无论是绝对握力还是相对握力）与PAD的发病呈剂量依赖性的反向关系。绝对握力每增加 1 千克，相对握力每增加 0.01 千克/千克，PAD 风险就会分别降低 2%（HR：0.98；95% CI [0.97-0.98]）和 83%（HR：0.17；95% CI [0.13-0.23]）。结论绝对握力、相对握力和步行速度与发生 PAD 的风险成反比。

{"title":"Association between grip strength, walking pace and incident peripheral artery disease: A prospective study of 430,886 UK biobank participants","authors":"Duqiu Liu , Chenxing Yang , Gang Liu , Tianyu Guo , Sen Liu , Yi Guo , Jinjie Xiong , Ru Chen , Shan Deng","doi":"10.1016/j.ijcrp.2024.200330","DOIUrl":"10.1016/j.ijcrp.2024.200330","url":null,"abstract":"<div><h3>Background and aims</h3><p>Patients with peripheral artery disease (PAD) presented overall muscle weakness and reduced physical performance. Previous study focused on the impact of muscle weakness on outcomes of established PAD, however the relationship between compromised muscle function and incident PAD remained unclear.</p></div><div><h3>Methods</h3><p>A prospective study involving 430,886 participants aged 40–69 y from UK biobank was conducted. The main outcome was incident PAD. Grip strength and walking pace were used as indicators for muscle function. Grip strength was measured using a Jamar J00105 hydraulic hand dynamometer, while walking pace was self-reported by the participants. Cox proportional hazard models were employed to investigate the relationship between grip strength, walking pace, and incident PAD.</p></div><div><h3>Results</h3><p>A total of 430,886 individuals were included in the final analysis. The mean age of the participants were 56.44 years, and 55.3 % were female. Over a median follow-up period of 13.81 years, 5,661 participants developed PAD. Higher grip strength, whether absolute or relative, exhibited a dose-dependent inverse association with incident PAD. Each 1 kg increment in absolute grip strength and each 0.01 kg/kg increase in relative grip strength were associated with reduced PAD risk by 2 % (HR: 0.98; 95 % CI [0.97–0.98]) and 83 % (HR: 0.17; 95 % CI [0.13–0.23]), respectively. Slow walking pace significantly correlated with increased PAD risk, while brisk walking pace was associated with decreased PAD risk.</p></div><div><h3>Conclusion</h3><p>Absolute grip strength, relative grip strength and walking pace were inversely associated with the risk of incident PAD.</p></div>","PeriodicalId":29726,"journal":{"name":"International Journal of Cardiology Cardiovascular Risk and Prevention","volume":"23 ","pages":"Article 200330"},"PeriodicalIF":1.9,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772487524000953/pdfft?md5=c24edaa56d5e1daa600dea4a2a4f2b9c&pid=1-s2.0-S2772487524000953-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0