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Pharmacological management of psychiatric agitation in COVID-19 hospitalized patients COVID-19住院患者精神躁动的药理管理
IF 5 Q1 HEALTH POLICY & SERVICES Pub Date : 2021-10-10 DOI: 10.5339/avi.2021.11
W. Abdelghaffar, H. Snen, N. Haloui, H. Blibech, R. Rafrafi
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引用次数: 0
Effects of the COVID-19 pandemic on perceived stress levels of employees working in private organizations during lockdown 新冠肺炎大流行对封锁期间在私人组织工作的员工感知压力水平的影响
IF 5 Q1 HEALTH POLICY & SERVICES Pub Date : 2021-10-10 DOI: 10.5339/avi.2021.7
A. Maqsood, J. Saleem, Muhammad Salman Butt, Ruhma Shahzad, Raja Zubair, M. Ishaq
Background Worldwide, office employees have experienced two novel phenomena during the COVID-19 pandemic and lockdown: working from home and reductions in their salaries. These phenomena have majorly impacted the lives of individuals as well as their families. The present study aims to measure the perceived stress levels among employees during the COVID-19 pandemic lockdown in Pakistan. Methodology A cross-sectional approach was used to collect data from a sample of 385 employees working in three different IT-oriented private organizations. A semi-structured, Likert-scale questionnaire was used, containing the 10-item inventory from the Perceived Stress Scale (PSS). A sociodemographic profile, working parameters, and frequency of PSS inventory were presented in the descriptive analysis. Binary logistic regression analysis was made to compare the stress levels of the two groups resulting from their workloads and reductions in salary. Results An elevated perceived stress level (50.9%) was observed among the employees, showing a significant relationship with salary reduction and home work engagement (p<0.005). A strong negative correlation was observed (-0.860) for the salary reduction with PSS. Conclusion Working from home and reductions in salary caused increased perceived stress levels of the employees working in private organizations. Salary reductions proved to be a strong stressor, causing economic disruption and inability to cope with financial burdens during the COVID-19 pandemic.
在全球范围内,办公室员工在COVID-19大流行和封锁期间经历了两种新现象:在家工作和减薪。这些现象严重影响了个人及其家庭的生活。本研究旨在测量巴基斯坦COVID-19大流行封锁期间员工的感知压力水平。方法采用横断面方法从三个不同的it导向的私营组织工作的385名员工样本中收集数据。采用半结构化的李克特量表问卷,其中包含来自感知压力量表(PSS)的10个项目清单。描述性分析提供了社会人口统计资料、工作参数和PSS调查频率。通过二元logistic回归分析,比较了两组因工作量和减薪而产生的压力水平。结果员工感知压力水平升高(50.9%),与减薪和家庭工作投入显著相关(p<0.005)。工资减少与PSS呈负相关(-0.860)。结论:在家办公和工资减少导致私营企业员工的压力水平增加。事实证明,减薪是一个强大的压力源,在2019冠状病毒病大流行期间造成经济中断和无法应对财务负担。
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引用次数: 10
COVID-19 and the mental health of professionals in the health sector in the UAE: An analytical study 新冠肺炎与阿联酋卫生部门专业人员的心理健康:一项分析研究
IF 5 Q1 HEALTH POLICY & SERVICES Pub Date : 2021-10-10 DOI: 10.5339/avi.2021.9
Chokri Kooli
As the Covid-19 pandemic persists, the public health interventions reported that many individuals during this pandemic situation experience different circumstances that lead to their poor mental health performance, such as isolation stress, anxiety, depression, anger, confusion, and unemployment. The aim of this study is to examine the existing literature in a comprehensive manner and to explore the impact of COVID-19 on the mental health of UAE health workers. This study also examined the psychological factors that influence workers’ mental health due to the pandemic of COVID-19. An online questionnaire was administered to answer the research question. The results proved that the pandemic has affected both physical and mental health of UAE health workers. Consequently, the adoption of preventive actions at the governmental, organizational, and individual levels is highly recommended. In this research, the implementation of effective communication and the application of adequate psychological services have been suggested. To this end, the role of policy makers to be involved in placing governmental initiatives that prevent the spread of the virus and protect the mental health of workers has been highlighted.
随着Covid-19大流行的持续,公共卫生干预措施报告说,在这次大流行期间,许多人经历了不同的情况,导致他们的心理健康表现不佳,如孤立压力、焦虑、抑郁、愤怒、困惑和失业。本研究的目的是全面检查现有文献,并探讨COVID-19对阿联酋卫生工作者心理健康的影响。本研究还研究了COVID-19大流行影响工人心理健康的心理因素。一份在线调查问卷被用来回答研究问题。结果证明,大流行影响了阿联酋卫生工作者的身心健康。因此,强烈建议在政府、组织和个人各级采取预防行动。在本研究中,提出了实施有效的沟通和适当的心理服务的建议。为此目的,强调了决策者参与制定政府倡议以防止病毒传播和保护工人心理健康的作用。
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引用次数: 8
COVID-19: Challenges and opportunities COVID-19:挑战与机遇
IF 5 Q1 HEALTH POLICY & SERVICES Pub Date : 2021-09-07 DOI: 10.5339/avi.2021.5
Chokri Kooli
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引用次数: 6
Psychological impact of COVID-19 pandemic among expatriate residents in the UAE COVID-19大流行对阿联酋外籍居民的心理影响
IF 5 Q1 HEALTH POLICY & SERVICES Pub Date : 2021-06-24 DOI: 10.5339/AVI.2021.3
Panthayil. K. Baburajan
The COVID-19 pandemic has devastated people and countries around the world. It has affected every aspect of human life. Despite the discovery of vaccines and widespread immunization drive which is a minor consolation, the consequences of it are likely to prevail for extended periods of time. This study explored the psychological impacts of the COVID-19 pandemic within the United Arab Emirates (UAE). An online survey was carried out among a sample of 78 expatriate residents. While most of the respondents recognized and highly valued the measures taken by the UAE government to support and deal with the pandemic, intense stress and uncertainty was reported. It was found that the Asian community was more anxious concerning the negative consequences of the pandemic than Arab or W stern residents. The worry among older people was also found to be more intense. Anxiety over health consequences, fear of job loss, and constraints for international travels were the most overwhelming concerns. The difficulties that the coronavirus has presented continue to devastate the psychological wellbeing of individuals even where an adequate governmental system for prevention and controlling the pandemic is in place.
新冠肺炎大流行摧毁了世界各地的人民和国家。它影响了人类生活的方方面面。尽管疫苗的发现和广泛的免疫接种运动只是一个小小的安慰,但其后果可能会持续很长一段时间。本研究探讨了新冠肺炎大流行对阿拉伯联合酋长国(UAE)的心理影响。对78名外籍居民进行了一项在线调查。尽管大多数受访者认可并高度评价阿联酋政府为支持和应对疫情所采取的措施,但据报道,他们面临着巨大的压力和不确定性。研究发现,与阿拉伯或W严厉的居民相比,亚裔社区更担心疫情的负面后果。老年人的担忧也更加强烈。对健康后果的焦虑、对失业的恐惧以及国际旅行的限制是最令人担忧的问题。即使有足够的政府系统来预防和控制疫情,冠状病毒带来的困难仍在继续破坏个人的心理健康。
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引用次数: 14
All those exanthematous fevers are not Covid-19 所有这些发疹性发烧都不是新冠肺炎
IF 5 Q1 HEALTH POLICY & SERVICES Pub Date : 2021-06-24 DOI: 10.5339/AVI.2021.1
Jaseem Sirajudeen, A. Nair, Rabia Waseem Hassany, N. Purayil, J. Mathew, I. Elmadhoun, M. Mustafa
Fever with a rash is a common case scenario that clinicians encounter in their practice. The ubiquity of the presentation is proportional to the magnitude of the physician's dilemma due to its numerous causes. The diagnosis varies from infectious diseases to non-infectious, life threatening diseases including the current COVID-19 pandemic. Here we present a case of a 31-year-old male, who presented to the Emergency Department with fever and rash and was initially diagnosed and managed as a case of COVID-19 which on further evaluation proved to be brucellosis. This is a case of brucellosis with cutaneous manifestations which had been masquerading as COVID-19.
发烧伴皮疹是临床医生在实践中遇到的常见病例。由于其众多原因,无处不在的呈现与医生困境的大小成正比。从传染病到非传染性、威胁生命的疾病,包括当前的COVID-19大流行,诊断各不相同。在这里,我们报告了一例31岁男性病例,他以发烧和皮疹就诊于急诊科,最初被诊断为COVID-19病例,经进一步评估证实为布鲁氏菌病。这是一例皮肤表现的布鲁氏菌病,被伪装成COVID-19。
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引用次数: 6
Psychological support unit design and implementation during COVID-19 pandemic: Case of Mongi Slim Hospital, Tunisia 新冠肺炎大流行期间心理支持单元的设计和实施:突尼斯蒙吉·斯利姆医院案例
IF 5 Q1 HEALTH POLICY & SERVICES Pub Date : 2021-06-24 DOI: 10.5339/AVI.2021.2
W. Abdelghaffar, N. Haloui, Noamen Bouchrika, Souha Yaakoubi, Amani Sarhane, Emna Kalai, Nihel Siala, Hajer Boulehmi, S. Trabelsi, S. Bourgou, F. Charfi, A. Belhadj, R. Rafrafi
General lockdown was declared in Tunisia in March 2020 due to the COVID-19 pandemic. It had a negative psychological and social impact on the Tunisian population and health professionals. Mental healthcare was crucial during this period but health services access was difficult because of movement restrictions. Mongi Slim Hospital contains three special COVID-19 units and there was an urgent need for a psychological intervention with increasing demands at the mental health department in this hospital. A psychological support unit (PSU) was implemented with a free helpline for both patients, families and hospital staff. The objective of this paper was to describe the design, implementation and activities of this unit. This PSU had preventive and management activities for both patients and health professionals. Recommendations drawn from this experience are to promote mental health care and to encourage implementation of such units in order to respond to the local need of patients and staff. This pilot experience should be generalized to other hospitals in Tunisia and worldwide.
由于新冠肺炎大流行,突尼斯于2020年3月宣布全面封锁。它对突尼斯人民和卫生专业人员产生了负面的心理和社会影响。在这一时期,心理健康是至关重要的,但由于行动限制,获得医疗服务很困难。Mongi Slim医院有三个特殊的新冠肺炎病房,随着该医院精神卫生部门的需求不断增加,迫切需要心理干预。设立了一个心理支持单位,为患者、家属和医院工作人员提供免费帮助热线。本文的目的是描述该单元的设计、实施和活动。该PSU为患者和卫生专业人员开展了预防和管理活动。从这一经验中得出的建议是促进心理健康护理,并鼓励实施此类单位,以满足当地患者和工作人员的需求。这一试点经验应推广到突尼斯和世界各地的其他医院。
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引用次数: 2
To win the global war against Covid-19 terror: free of charge vaccine to all people who want to be vaccinated 赢得全球抗击新冠肺炎恐怖战争:向所有想接种疫苗的人免费接种疫苗
IF 5 Q1 HEALTH POLICY & SERVICES Pub Date : 2021-06-24 DOI: 10.5339/AVI.2021.4
M. Zakaria
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引用次数: 5
After one year of COVID-19 Pandemic and Hundreds of Suggested Drugs, Will Cathepsin L Inhibitors be the Solution? 经过一年的COVID-19大流行和数百种推荐药物,组织蛋白酶L抑制剂会是解决方案吗?
IF 5 Q1 HEALTH POLICY & SERVICES Pub Date : 2021-04-22 DOI: 10.14293/S2199-1006.1.SOR-.PPAJTMC.V1
A. Ahmed
Cysteine cathepsins are defined as lysosomal enzymes which are member of the papain family. Cysteine cathepsins (Cts) prevalently exist in whole organisms varying from prokaryotes to mammals and possess in their active site greatly conserved residue of cysteine. Cts are engaged in the digestion of cellular protein, activation of zymogen, and remodeling of extracellular matrix (ECM). Host cells are entered by SARS-CoV-2 via endocytosis. Cathepsin L and phosphatidylinositol 3-phosphate 5-kinase are crucial in terms of the endocytosis by cleaving the spike protein, which permits viral membrane fusion with endosomal membrane, and succeeded by the releasing of viral genome to the host cell. Thereby, inhibition of cathepsin L may be advantageous in terms of decreasing infection caused by SARS-CoV-2. Coordinate inhibition of multiple Cts and lysosomal function by different drugs and biological agents might be of value for some purposes such as parasite or viral infections and anti-neoplastic applications. It has been found that Zn 2+ deficiency or dysregulation leads to an exaggerated activity of Cysteine cathepsin increasing the autoimmune/inflammatory response. At this purpose Zn 2+ metal can be safely combined with a drug that increases the anti-proteolytic effect of endogenous Zn 2+ lowering the excessive activity of some CysCts. Biguanide derivatives complex with Zn 2+ have been found to be promising inhibitors of CysCts protease reactions. Molecular docking studies of Cathepsin L Inhibited by Metformin-Zn+2 complex have been performed showing two strong key interactions ( Cys-25&His-163) and an extra H-bond with Asp-163 compared to the co-crystallized Zn +2 (PDB ID 4axl).
半胱氨酸组织蛋白酶被定义为属于木瓜蛋白酶家族的溶酶体酶。半胱氨酸组织蛋白酶(Cts)普遍存在于从原核生物到哺乳动物的整个生物体中,其活性位点具有非常保守的半胱氨酸残基。Cts参与细胞蛋白质的消化、酶原的激活和细胞外基质(ECM)的重塑。宿主细胞通过内吞作用进入严重急性呼吸系统综合征冠状病毒2型。组织蛋白酶L和磷脂酰肌醇3-磷酸5-激酶通过裂解刺突蛋白进行内吞作用至关重要,刺突蛋白允许病毒膜与内涵体膜融合,并成功地将病毒基因组释放到宿主细胞。因此,抑制组织蛋白酶L在减少由严重急性呼吸系统综合征冠状病毒2引起的感染方面可能是有利的。不同药物和生物制剂对多种Ct和溶酶体功能的协同抑制可能对某些目的有价值,如寄生虫或病毒感染和抗肿瘤应用。已经发现Zn2+缺乏或失调导致半胱氨酸组织蛋白酶的活性增强,从而增加自身免疫/炎症反应。为此,Zn2+金属可以与一种药物安全地结合,该药物增加内源性Zn2+的抗蛋白水解作用,降低一些CysCts的过度活性。双胍衍生物与Zn2+的配合物已被发现是CysCts蛋白酶反应的有前途的抑制剂。Metformin-Zn+2复合物抑制组织蛋白酶L的分子对接研究表明,与共结晶的Zn+2(PDB ID 4axl)相比,组织蛋白酶有两个强的关键相互作用(Cys-25和His-163)和与Asp-163的额外氢键。
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