{"title":"Synthesis, molecular docking and anti-inflammatory potential of novel hydrazones of eugenol in tuberculosis treatment","authors":"","doi":"10.56042/ijc.v62i6.2507","DOIUrl":"https://doi.org/10.56042/ijc.v62i6.2507","url":null,"abstract":"","PeriodicalId":29765,"journal":{"name":"INDIAN JOURNAL OF CHEMISTRY","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45839640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Viscometric and refractive index study of intermolecular interaction between binary mixtures of terpinolene with o-, m- and p-cresol at 303.15, 308.15 and 313.15 K","authors":"","doi":"10.56042/ijc.v62i6.2521","DOIUrl":"https://doi.org/10.56042/ijc.v62i6.2521","url":null,"abstract":"","PeriodicalId":29765,"journal":{"name":"INDIAN JOURNAL OF CHEMISTRY","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45163878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of drug likeliness of (Z)-4-((4-hydroxy-3-methoxy benzylidene)amino)-1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one by computational analysis against coronavirus and T-cells of immune system","authors":"","doi":"10.56042/ijc.v62i6.2511","DOIUrl":"https://doi.org/10.56042/ijc.v62i6.2511","url":null,"abstract":"","PeriodicalId":29765,"journal":{"name":"INDIAN JOURNAL OF CHEMISTRY","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44854842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A study on synthesis, antioxidant, anticancer activities and docking study of novel benzimidazoloyl thiazole derivatives","authors":"","doi":"10.56042/ijc.v62i6.2514","DOIUrl":"https://doi.org/10.56042/ijc.v62i6.2514","url":null,"abstract":"","PeriodicalId":29765,"journal":{"name":"INDIAN JOURNAL OF CHEMISTRY","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41933890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anirudhdha G. Kalola, P. Prasad, Roshni D Hingrajiya, Manish P Patel
A new copper sulphate anchored to an acrylonitrile-N-isopropylacrylamide-bisacrylamide based P(AN-NIPAM-MBAM) terpolymer support has been employed as a catalyst for the hydrogenation of varied substituted nitro-arenes affording corresponding amines with excellent yield. Application of hydrogen source from NaBH 4 in combination with NaOH under water and/or methanol solvent system at 50-55°C has been investigated. The terpolymer and catalyst have been characterized by ICP-OES, FT-IR, TGA, SEM and EDAX analysis methods. Different parameters supporting chemo-selective hydrogenation such as concentration of NaBH 4 , TP-CuSO 4 , assisting base and solvents have been investigated. Controllable vigorous H 2 gas evolution, low-temperature requirement, feasibility under air atmosphere, low catalyst loading, use of non-toxic reagents and solvents, high isolated yield, easy work-up procedure, purification without involving tedious column or flash chromatographic separation techniques, makes this protocol highly significant from the implementation point of view.
以丙烯腈- n -异丙基丙烯酰胺-双丙烯酰胺基P(an - nipam - mbam)三元共聚物为载体，采用一种新型硫酸铜作为催化剂，催化各种取代的硝基芳烃加氢反应，产率高。研究了在50-55℃的水溶液和/或甲醇溶剂体系下，nabh4与NaOH结合制氢的应用。采用ICP-OES、FT-IR、TGA、SEM和EDAX等分析方法对三元共聚物和催化剂进行了表征。考察了nabh4、tp - cuso4浓度、辅助碱和溶剂等参数对化学选择性加氢反应的影响。可控的剧烈h2气体析出，低温要求，在空气气氛下的可行性，低催化剂负荷，使用无毒试剂和溶剂，高分离收率，易于处理程序，净化不涉及繁琐的柱或闪蒸色谱分离技术，从实施的角度来看，该方案具有重要意义。
{"title":"Copper sulphate immobilized on P(AN-NIPAM-MBAM) terpolymer as a highly efficient catalyst for the selective reduction of nitro-arenes","authors":"Anirudhdha G. Kalola, P. Prasad, Roshni D Hingrajiya, Manish P Patel","doi":"10.56042/ijc.v62i6.2534","DOIUrl":"https://doi.org/10.56042/ijc.v62i6.2534","url":null,"abstract":"A new copper sulphate anchored to an acrylonitrile-N-isopropylacrylamide-bisacrylamide based P(AN-NIPAM-MBAM) terpolymer support has been employed as a catalyst for the hydrogenation of varied substituted nitro-arenes affording corresponding amines with excellent yield. Application of hydrogen source from NaBH 4 in combination with NaOH under water and/or methanol solvent system at 50-55°C has been investigated. The terpolymer and catalyst have been characterized by ICP-OES, FT-IR, TGA, SEM and EDAX analysis methods. Different parameters supporting chemo-selective hydrogenation such as concentration of NaBH 4 , TP-CuSO 4 , assisting base and solvents have been investigated. Controllable vigorous H 2 gas evolution, low-temperature requirement, feasibility under air atmosphere, low catalyst loading, use of non-toxic reagents and solvents, high isolated yield, easy work-up procedure, purification without involving tedious column or flash chromatographic separation techniques, makes this protocol highly significant from the implementation point of view.","PeriodicalId":29765,"journal":{"name":"INDIAN JOURNAL OF CHEMISTRY","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45833972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis of N-aryl derived formamides using triflic anhydride","authors":"","doi":"10.56042/ijc.v62i6.2569","DOIUrl":"https://doi.org/10.56042/ijc.v62i6.2569","url":null,"abstract":"","PeriodicalId":29765,"journal":{"name":"INDIAN JOURNAL OF CHEMISTRY","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46268003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhanced photoactivity effect of Ag metal loading on Zr4+ doped N-TiO2 obtained by microwave assisted method","authors":"","doi":"10.56042/ijc.v62i6.2527","DOIUrl":"https://doi.org/10.56042/ijc.v62i6.2527","url":null,"abstract":"","PeriodicalId":29765,"journal":{"name":"INDIAN JOURNAL OF CHEMISTRY","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46636714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The presence of a reactive α,β-unsaturated keto group along with substituted aryl ring improves biological profile of pyrazoline nucleus. Considering this fact a study was planned to synthesize novel pyrazoline derivatives incorporated with chalcone backbone and their evaluation as COX-2 inhibitors and anti-inflammatory agents. Bovine serum albumin denaturation assay was used to measure in vitro anti-inflammatory activity. Molecular docking study was performed using Schrödinger-Maestro 9.0 molecular docking software and cyclooxygenase-2 (COX-II) receptor PDB ID: 4-COX. Some of the synthesized compounds showed remarkable anti-inflammatory potential. The compound (E)-3-(4-hydroxyphenyl)-1-(3-(4-hydroxyphenyl)-5-phenyl-4,5-dihydropyrazol-1-yl)prop-2-en-1-one 6d was found to be the most potent anti-inflammatory agents with 69.88% inhibition of protein denaturation. The outcome of docking study also supported results of in vitro anti-inflammatory activity and docking score for compound 6d was found to be –6.70379 which was comparable to the co-crystallized ligand. The results reveal that the synthesized compound can serve as potential lead for the development of novel anti-inflammatory agents.
{"title":"In vitro and in silico studies on novel N-substituted-3,5-diaryl-pyrazoline derivatives as COX-2 inhibitors and anti-inflammatory agents","authors":"U. Bhadoriya, D. Kumar, Jain","doi":"10.56042/ijc.v62i6.2532","DOIUrl":"https://doi.org/10.56042/ijc.v62i6.2532","url":null,"abstract":"The presence of a reactive α,β-unsaturated keto group along with substituted aryl ring improves biological profile of pyrazoline nucleus. Considering this fact a study was planned to synthesize novel pyrazoline derivatives incorporated with chalcone backbone and their evaluation as COX-2 inhibitors and anti-inflammatory agents. Bovine serum albumin denaturation assay was used to measure in vitro anti-inflammatory activity. Molecular docking study was performed using Schrödinger-Maestro 9.0 molecular docking software and cyclooxygenase-2 (COX-II) receptor PDB ID: 4-COX. Some of the synthesized compounds showed remarkable anti-inflammatory potential. The compound (E)-3-(4-hydroxyphenyl)-1-(3-(4-hydroxyphenyl)-5-phenyl-4,5-dihydropyrazol-1-yl)prop-2-en-1-one 6d was found to be the most potent anti-inflammatory agents with 69.88% inhibition of protein denaturation. The outcome of docking study also supported results of in vitro anti-inflammatory activity and docking score for compound 6d was found to be –6.70379 which was comparable to the co-crystallized ligand. The results reveal that the synthesized compound can serve as potential lead for the development of novel anti-inflammatory agents.","PeriodicalId":29765,"journal":{"name":"INDIAN JOURNAL OF CHEMISTRY","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48105169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Syntheses and characterizations of 2-nitrobenzaldehyde amino acid Schiff base reductive amination compounds","authors":"","doi":"10.56042/ijc.v62i5.1408","DOIUrl":"https://doi.org/10.56042/ijc.v62i5.1408","url":null,"abstract":"","PeriodicalId":29765,"journal":{"name":"INDIAN JOURNAL OF CHEMISTRY","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46781966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An effective colorimetric and fluorescent chemosensor derived from modified curcumin for the detection of the Fe3+ ion","authors":"","doi":"10.56042/ijc.v62i5.1451","DOIUrl":"https://doi.org/10.56042/ijc.v62i5.1451","url":null,"abstract":"","PeriodicalId":29765,"journal":{"name":"INDIAN JOURNAL OF CHEMISTRY","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43792035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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