Pub Date : 2022-08-01DOI: 10.23736/s2784-8477.21.01964-1
M. Lakranbi, M. Rhaouti, Fatima E. Lamouime, S. Rabiou, Maha Tachaouine, Y. Ouadnouni, M. Smahi
{"title":"The place of blood patch pleurodesis in the management of inoperable spontaneous pneumothorax","authors":"M. Lakranbi, M. Rhaouti, Fatima E. Lamouime, S. Rabiou, Maha Tachaouine, Y. Ouadnouni, M. Smahi","doi":"10.23736/s2784-8477.21.01964-1","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01964-1","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"1 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86641731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.23736/s2784-8477.21.01961-6
Meenakshi S. Kushwah, Arunkrishnan Balaravi, L. Venugopalan, Sreekanth Ramashenoy, Anita Chrisbina, Monisha Prabhakarn, Sumaiya Alauddin, Munmun Sahney, Manoj K. Deenadayalan, P. Petchimuthu
Increasing incidences of COVID-19 in pregnant women, and lack of data regarding vertical transmission and extent of disease in newborns, has raised a concern towards it. The fetal inflammatory response syndrome (FIRS) and multisystem inflammatory syndrome in neonates (MIS-N) is also not a well-known entity till now. This case report of two newborns is an effort to describe the different clinical scenarios of COVID-19 and its response to the treatment. The first case suggests the possible in utero transmission which is a rare mode of infection as evident from previous data and the inflammatory response, getting treated by the use of immunotherapy and antivirals. The second case suggest the horizontal transmission acquired postnatally and the severity of multisystem inflammatory syndrome in neonate which could not be revived in spite all the efforts in treatment.
{"title":"Fetal inflammatory response syndrome and postnatal multi-system inflammatory syndrome in COVID-19-positive neonates","authors":"Meenakshi S. Kushwah, Arunkrishnan Balaravi, L. Venugopalan, Sreekanth Ramashenoy, Anita Chrisbina, Monisha Prabhakarn, Sumaiya Alauddin, Munmun Sahney, Manoj K. Deenadayalan, P. Petchimuthu","doi":"10.23736/s2784-8477.21.01961-6","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01961-6","url":null,"abstract":"Increasing incidences of COVID-19 in pregnant women, and lack of data regarding vertical transmission and extent of disease in newborns, has raised a concern towards it. The fetal inflammatory response syndrome (FIRS) and multisystem inflammatory syndrome in neonates (MIS-N) is also not a well-known entity till now. This case report of two newborns is an effort to describe the different clinical scenarios of COVID-19 and its response to the treatment. The first case suggests the possible in utero transmission which is a rare mode of infection as evident from previous data and the inflammatory response, getting treated by the use of immunotherapy and antivirals. The second case suggest the horizontal transmission acquired postnatally and the severity of multisystem inflammatory syndrome in neonate which could not be revived in spite all the efforts in treatment.","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"72 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88909035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.23736/s2784-8477.21.01968-9
M. Patruno, S. Dragonieri, Francesca Addante, S. Patruno, P. Portincasa, P. Carratù
{"title":"A successfully home-treated adverse reaction to cefepime in a geriatric patient","authors":"M. Patruno, S. Dragonieri, Francesca Addante, S. Patruno, P. Portincasa, P. Carratù","doi":"10.23736/s2784-8477.21.01968-9","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01968-9","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"178 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77768754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.23736/s2784-8477.21.01959-8
G. Segrelles-Calvo, Estefanía Llopis-Pastor, Esther ANTÓN-DÍAZ, I. Escribano, L. Rey, Glauber Ribeiro de Sousa Araújo, Marta Hernandez-Hernandez, Nestór RODRÍGUEZ-MELEAN, C. Zamarro, Javier Carrillo Hernández-Rubio, Elena ALONSO-VILLÁN, S. Frases, Mercedes García-Salmones
BACKGROUND: In the present study we aimed to analyze the response to non-invasive respiratory support in patients stratified with acute respiratory failure due to novel coronavirus disease. METHODS: A prospective, observational study was carried out in Hospital Universitario Rey Juan Carlos from February 1st to June 30th, 2020. The study was approved by the Ethics Committee of the Fundacion Jimenez Diaz. We included patients over 18 years of age with confirmed SARS-CoV-2 infection who required non-invasive respiratory support (N.=130). We classified patients included in the sample according to the three clinical scenarios established by the Spanish Respiratory Society. RESULTS: The mean age of the patients was 64.3 +/- 12.9 years;43.8% were older than 70, and the majority were male (N.=88;67.7%). Eighty percent of the study population (N.=104) presented comorbidities. The most used device was the continuous positive airway pressure (54.6%, N.=71). Non-invasive respiratory support-based treatment avoided Intensive Care Unit admission in 68% of the acute respiratory failure cases studied. Treatment-failure occurred in 43.8% of patients (37% clinical scenario 1, de-novo acute respiratory failure, P=0.04) and the overall rate of mortality was 36.2% (14.8% clinical scenario 1, P<0.00001). CONCLUSIONS: The used of non-invasive respiratory support was safe and clinically effective treatment (68% of ICU admissions prevented, lower rate of TF than that reported for other viral pneumonias, and a mortality rate of 14.8% within clinical scenario 1). Non-invasive respiratory support may be considered a first-line therapy for patients with severe COVID-19.
{"title":"Clinical outcomes in patients with severe respiratory failure due to novel coronavirus disease 2019 treated with non-invasive respiratory support: observational, prospective study","authors":"G. Segrelles-Calvo, Estefanía Llopis-Pastor, Esther ANTÓN-DÍAZ, I. Escribano, L. Rey, Glauber Ribeiro de Sousa Araújo, Marta Hernandez-Hernandez, Nestór RODRÍGUEZ-MELEAN, C. Zamarro, Javier Carrillo Hernández-Rubio, Elena ALONSO-VILLÁN, S. Frases, Mercedes García-Salmones","doi":"10.23736/s2784-8477.21.01959-8","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01959-8","url":null,"abstract":"BACKGROUND: In the present study we aimed to analyze the response to non-invasive respiratory support in patients stratified with acute respiratory failure due to novel coronavirus disease. METHODS: A prospective, observational study was carried out in Hospital Universitario Rey Juan Carlos from February 1st to June 30th, 2020. The study was approved by the Ethics Committee of the Fundacion Jimenez Diaz. We included patients over 18 years of age with confirmed SARS-CoV-2 infection who required non-invasive respiratory support (N.=130). We classified patients included in the sample according to the three clinical scenarios established by the Spanish Respiratory Society. RESULTS: The mean age of the patients was 64.3 +/- 12.9 years;43.8% were older than 70, and the majority were male (N.=88;67.7%). Eighty percent of the study population (N.=104) presented comorbidities. The most used device was the continuous positive airway pressure (54.6%, N.=71). Non-invasive respiratory support-based treatment avoided Intensive Care Unit admission in 68% of the acute respiratory failure cases studied. Treatment-failure occurred in 43.8% of patients (37% clinical scenario 1, de-novo acute respiratory failure, P=0.04) and the overall rate of mortality was 36.2% (14.8% clinical scenario 1, P<0.00001). CONCLUSIONS: The used of non-invasive respiratory support was safe and clinically effective treatment (68% of ICU admissions prevented, lower rate of TF than that reported for other viral pneumonias, and a mortality rate of 14.8% within clinical scenario 1). Non-invasive respiratory support may be considered a first-line therapy for patients with severe COVID-19.","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"38 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74109346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.23736/s2784-8477.22.02013-7
C. Martelli, Roberto Rana, F. Alfano, Chiara Arena, F. Baraldi, Tommaso Bigoni, S. Casanova, M. Cometa, Martina Pompignoli, Federica Santoli, Enea Tazzari, Francesca Urbani, A. Ursitti, M. Contoli, A. Papi
Male and female patients are usually considered clinically equivalent from a diagnostic and treatment point of view, and no relevance is given to the differences in morphometry and physiology of the respiratory system between the two sexes. This is a major limitation in the understanding of the pathology and effective management of multiple respiratory ailments. The present review analyses the available literature on the major respiratory diseases from a gender-difference perspective. We performed our research using the PubMed Advanced Browser. The research for each clinical condition was conducted by using the key words "gender" OR "sex." For example, considering asthma, the search criteria were "asthma" AND "gender" OR "sex." All the respiratory diseases considered in this review are deeply influenced by the sex of the patient in diverse ways. For example, in women, estrogens could play a protective role in some conditions, like IPF, while in others they are associated with increased risk of disease development, as in some types of severe asthma. Psychological symptoms are more frequent in women with obstructive conditions such as OSAS, COPD, and asthma. Despite the available evidence, current therapeutic strategies largely ignore these differences, and data on gender-weighted interventions are still scarce. Sex differences are common in respiratory diseases. They have largely been ignored in clinical approaches towards these diseases. Evidence has been generated in the last few decades in favor of gender-based diagnostic and therapeutic strategies.
{"title":"The impact of gender differences on pulmonary diseases and their clinical implications","authors":"C. Martelli, Roberto Rana, F. Alfano, Chiara Arena, F. Baraldi, Tommaso Bigoni, S. Casanova, M. Cometa, Martina Pompignoli, Federica Santoli, Enea Tazzari, Francesca Urbani, A. Ursitti, M. Contoli, A. Papi","doi":"10.23736/s2784-8477.22.02013-7","DOIUrl":"https://doi.org/10.23736/s2784-8477.22.02013-7","url":null,"abstract":"Male and female patients are usually considered clinically equivalent from a diagnostic and treatment point of view, and no relevance is given to the differences in morphometry and physiology of the respiratory system between the two sexes. This is a major limitation in the understanding of the pathology and effective management of multiple respiratory ailments. The present review analyses the available literature on the major respiratory diseases from a gender-difference perspective. We performed our research using the PubMed Advanced Browser. The research for each clinical condition was conducted by using the key words \"gender\" OR \"sex.\" For example, considering asthma, the search criteria were \"asthma\" AND \"gender\" OR \"sex.\" All the respiratory diseases considered in this review are deeply influenced by the sex of the patient in diverse ways. For example, in women, estrogens could play a protective role in some conditions, like IPF, while in others they are associated with increased risk of disease development, as in some types of severe asthma. Psychological symptoms are more frequent in women with obstructive conditions such as OSAS, COPD, and asthma. Despite the available evidence, current therapeutic strategies largely ignore these differences, and data on gender-weighted interventions are still scarce. Sex differences are common in respiratory diseases. They have largely been ignored in clinical approaches towards these diseases. Evidence has been generated in the last few decades in favor of gender-based diagnostic and therapeutic strategies.","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"52 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87748400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.23736/s2784-8477.21.01970-7
Mohammad H. Talischi, A. Mohamadnia, M. Mahmoodi, N. Bahrami, Abdollah Farhadi Nasab
{"title":"Increasing or decreasing the expression of miR-199, miR-210 and miR-143 and the effect on cell growth, apoptosis and angiogenesis through the expression of target genes in non-small cell lung cancer","authors":"Mohammad H. Talischi, A. Mohamadnia, M. Mahmoodi, N. Bahrami, Abdollah Farhadi Nasab","doi":"10.23736/s2784-8477.21.01970-7","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01970-7","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"128 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74488441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-01DOI: 10.23736/s2784-8477.22.01999-4
E. Zinellu, A. Zinellu, M. C. Pau, A. Fois, S. Mellino, A. Mangoni, C. Carru, P. Pirina
{"title":"Paraoxonase-1 in stable chronic obstructive pulmonary disease: a systematic review and meta-analysis","authors":"E. Zinellu, A. Zinellu, M. C. Pau, A. Fois, S. Mellino, A. Mangoni, C. Carru, P. Pirina","doi":"10.23736/s2784-8477.22.01999-4","DOIUrl":"https://doi.org/10.23736/s2784-8477.22.01999-4","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"47 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87369583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.23736/s2784-8477.21.01951-3
M. Garcia
{"title":"Rapidly fatal disseminated histoplasmosis presenting as acute respiratory distress syndrome in a patient with HIV","authors":"M. Garcia","doi":"10.23736/s2784-8477.21.01951-3","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01951-3","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"8 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81419146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.23736/s2784-8477.21.01950-1
A. Caranti, S. Savini, Anna Bonsembiante, C. Bianchini, A. Ciorba, S. Pelucchi
{"title":"Concomitant pneumomediastinum and pneumoneck due to self-induced vomiting: cues from a case","authors":"A. Caranti, S. Savini, Anna Bonsembiante, C. Bianchini, A. Ciorba, S. Pelucchi","doi":"10.23736/s2784-8477.21.01950-1","DOIUrl":"https://doi.org/10.23736/s2784-8477.21.01950-1","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"150 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77433778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-01DOI: 10.23736/s2784-8477.22.01995-7
S. Aliberti, F. Amati, A. Annunziata, F. Arcoleo, P. Baderna, F. Bini, Chiara F. Carraro, L. Iannacci, S. Lo Cicero, G. Passalacqua, D. Piloni, G. Scioscia, C. Seebacher, E. Sortino, A. Spacone, A. Vianello
{"title":"Diagnosis and management of patients with α1-antitrypsin deficiency: an Italian perspective","authors":"S. Aliberti, F. Amati, A. Annunziata, F. Arcoleo, P. Baderna, F. Bini, Chiara F. Carraro, L. Iannacci, S. Lo Cicero, G. Passalacqua, D. Piloni, G. Scioscia, C. Seebacher, E. Sortino, A. Spacone, A. Vianello","doi":"10.23736/s2784-8477.22.01995-7","DOIUrl":"https://doi.org/10.23736/s2784-8477.22.01995-7","url":null,"abstract":"","PeriodicalId":29817,"journal":{"name":"Minerva Respiratory Medicine","volume":"34 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76152150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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